Port Connector

Abstract

This disclosure relates to a port connector for sterilizing the exposed surface of a fluid port of an article to be sterilized in a sterilization device. [Solution] The port connector may include a housing that connects to a fluid port. The housing may define an inlet that fluid-couples to the fluid port, an outlet that fluid-couples to a sterilizer, and a fluid passage that fluid-couples the inlet and the outlet. The port connector may include a porous member supported by the housing. The porous member has a porous structure that partitions a plurality of micro-passages. The porous member is positioned relative to the housing to engage with the fluid port when the port connector is connected to the fluid port.

Description

Cross - reference to related applications

[0001] This application claims priority to U.S. Provisional Application No. 63 / 193,377, filed May 26, 2021, which is hereby incorporated by reference in its entirety.

Technical Field

[0002] The present disclosure generally relates to port connectors, and more specifically to port connectors for sterilizing the surface of fluid ports.

Background Art

[0003] Certain articles, such as medical devices (e.g., endoscopes), need to be sterilized between uses. These articles can include internal lumens that require sterilization. One way to sterilize these internal lumens is to move a sterilizing fluid or agent through the lumen. To move the sterilizing fluid through the lumen, a port connector is generally coupled to the fluid port of the article.

[0004] For example, WO 2018 / 090133 describes a sterilization system in which an endoscope is placed in a chamber having a port connector attached to a fluid port of the endoscope. The port connector fluidly couples the internal lumen of the endoscope to a pressure source (e.g., a negative pressure source). To sterilize the internal lumen of the endoscope, a sterilizing fluid (such as hydrogen peroxide vapor) is introduced into the chamber and then drawn through the internal lumen of the endoscope via the pressure source that is fluidly coupled to the endoscope by the port connector.

Summary of the Invention

[0005] In one embodiment, a port connector is disclosed for connecting a device to be sterilized to a sterilizer to a fluid port. The fluid port has a distal end defining a fluid port outlet. The fluid port defines a lumen extending proximal to the fluid port outlet. The port connector comprises a housing configured to couple with the fluid port. The housing defines an inlet configured to fluidly couple with the lumen of the fluid port, an outlet configured to fluidly couple with the sterilizer, and a fluid passage extending between the inlet and outlet to fluidly couple the inlet and outlet. A porous member is supported by the housing. The porous member has a porous structure that partitions a plurality of micro-passages. The porous member is positioned relative to the housing to engage with the distal end of the fluid port when the port connector is connected to the fluid port.

[0006] In another embodiment, a method for sterilizing a device having a fluid port includes the step of connecting a port connector to the fluid port. The port connector defines an inlet, an outlet, and a fluid passage extending between the inlet and outlet to fluidly connect the inlet and outlet, which are in fluid communication with the fluid port. The port connector has a porous member that engages with the end of the fluid port. The method includes the steps of fluidly connecting a sterilizer to the outlet of the port connector and sterilizing the end of the fluid port by moving a sterilizing fluid through the porous member while the port connector is connected to the fluid port.

[0007] In another embodiment, a port connector for connecting a fluid port of a device to be sterilized to a sterilizer comprises a housing configured to couple with the fluid port. The housing defines an outlet configured to fluidly couple to the sterilizer. A seal is positioned to form a fluid-tight seal with the fluid port. A piston is supported by the housing and is movable relative to the housing when a pressure difference is applied by the sterilizer.

[0008] In another embodiment, a port connector for connecting a device to be sterilized to a sterilizer comprises a porous member having a porous structure that defines a plurality of micro-passages, the fluid port defining a lumen. The porous member defines at least a portion of a receiving chamber that is dimensioned and formed to receive the fluid port. The inner surface is arranged to engage with the fluid port when the fluid port is placed within the receiving chamber. A housing is coupled to the porous member. The housing defines an inlet configured to fluid-couple to the lumen of the fluid port, an outlet configured to fluid-couple to the sterilizer, and a fluid passage extending between the inlet and outlet to fluid-couple the inlet and outlet. The inlet is located in the at least portion of the receiving chamber defined by the inner surface of the porous member.

[0009] Other purposes and features of this disclosure are partially apparent and partially pointed out herein. [Brief explanation of the drawing]

[0010] [Figure 1] This is a perspective view of a port connector according to one embodiment of the present disclosure, which is connected to a fluid port. [Figure 2] This is a longitudinal cross-section of a port connector. [Figure 3] This is a magnified view of a portion of Figure 2. [Figure 4] Figure 1 is a perspective view of the port connector. [Figure 5] Figure 1 is an exploded view of the port connector. [Figure 6] Figure 1 is a cross-sectional view of the port connector gasket. [Figure 7] This is a perspective view of a port connector according to another embodiment of the present disclosure, which is connected to a fluid port. [Figure 8] This is a longitudinal cross-section of a port connector. [Figure 8A] This is a longitudinal cross-sectional view of another embodiment of a port connector similar to the port connector in Figure 7. [Figure 9]It is an enlarged partial view of FIG. 8 where the gasket of the port connector is in the initial position. [Figure 10] It is an enlarged partial view of FIG. 8 where the gasket is in the sealing position. [Figure 11] It is a perspective view of the port connector of FIG. 7. [Figure 12] It is an exploded view of the port connector of FIG. 7. [Figure 13] It is a perspective view of the slide of the port connector of FIG. 7. [Figure 14] It is a perspective view of the plunger of the port connector of FIG. 7. [Figure 15] It is a perspective view of a port connector according to another embodiment of the present disclosure. [Figure 16] It is a perspective view of the port connector of FIG. 16 connected to a fluid port. [[ID=​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Figure 24 is a cross-sectional view with the porous material removed to reveal the internal details.

[0011] Corresponding reference numerals indicate the corresponding parts throughout the drawing. [Modes for carrying out the invention]

[0012] The port connectors disclosed herein can be used in conjunction with the sterilization systems and methods described in International Publication No. 2018 / 090133. The port connectors described herein allow the fluid port itself to be sterilized even when the port connector is installed. The port connectors allow the sterilization fluid to come into contact with the inner and / or outer surfaces of the fluid port, which would be blocked or covered if a conventional port connector were used, and thus generally allow the entire fluid port to be sterilized, more specifically the outer or exposed surfaces being closest to the lumen of the fluid port, as these surfaces are most likely to come into contact with the fluid flowing through the fluid port. The port connectors disclosed herein may be called leaky connectors because the port connector may not form a fluid seal with the fluid port, and / or may form a fluid seal with the fluid port only under certain conditions.

[0013] Referring to Figures 1 to 6, one embodiment of the port connector according to the present disclosure is shown collectively by reference numeral 100. The port connector 100 is shown attached to a fluid port 10 of an article (not shown), such as an endoscope. The illustrated fluid port 10 is a male fluid port having one or more circumferential barbs on its exterior to facilitate the connection and sealing of components and devices (such as tubes) to the fluid port, as is commonly known in the art. As shown in Figures 2 and 3, the fluid port defines a fluid port outlet 16 at its end (e.g., distal end or free end) and a lumen 12 extending proximal to the fluid port outlet. The fluid port 10 has a distal end face 14 (broadly speaking, an outer face) at its end. The distal end face 14 faces distally and is adjacent to the fluid port outlet 16. Other configurations of the fluid port are within the scope of the present disclosure. The port connector 100 is used to connect the fluid port 10 of an article or device to be sterilized (by a sterilizing fluid) to a pressure source (e.g., a negative pressure source and / or a positive pressure source) of a sterilization system or apparatus (not shown), such as the sterilization system described in International Publication No. 2018 / 090133. In one embodiment, the pressure source is a negative pressure source that creates a pressure difference to sterilize the inner surface (e.g., the inner lumen) of the article by drawing fluid (e.g., a sterilizing fluid) from the environment surrounding the article and the port connector 100 through the fluid port 10 and the port connector into the internal lumen of the article. The negative pressure source can be any suitable pressure source, such as a vacuum, a pump, or a chamber having a pressure lower than the environment surrounding the article.

[0014] The port connector 100 includes a housing 102. The housing 102 has a proximal end and a distal end. The proximal end defines an inlet 104 (Figure 3) configured to fluidly couple to a fluid port (for example, the inlet is positioned to fluidly communicate with the fluid port). In the illustrated embodiment, the proximal end includes an insertion portion 103 formed to be dimensioned and inserted into the lumen 12 of the fluid port 10 through a fluid port outlet 16, such that the inlet 104 is positioned within the lumen. The insertion portion 103 defines the inlet 104. Preferably, the insertion portion 103 does not engage with the fluid port 10. The distal end (for example, the distal port) defines an outlet 106 configured to fluidly couple to a negative pressure source (broadly, a sterilizer). In other words, the outlet 106 is positioned to fluidly communicate with the negative pressure source. In the illustrated embodiment, the distal end is configured to be coupled to a fluid conduit or tube to fluidly couple the outlet 106 to the negative pressure source. The distal end is equipped with a tube port fitting with a hook-shaped portion. The housing 102 defines a fluid passage 108 (e.g., lumen, hole) that extends between the inlet 104 and the outlet 106 and fluidly couples the inlet 104 and the outlet 106 (e.g., provides fluid communication between the inlet 104 and the outlet 106).

[0015] The housing 102 is configured to be coupled to the fluid port 10. The housing 102 includes a coupler 110 configured to be coupled (e.g., fitted) to the fluid port 10. In the illustrated embodiment, the coupler 110 comprises first and second elastically flexible clips 112. The first and second clips 112 are configured to engage with the fluid port 10 to couple (e.g., secure) the port connector 100 to the fluid port. Each clip 112 includes a retainer 114 configured to engage with the fluid port 10 to secure the port connector 100 to the fluid port. The retainer 114 engages with the hook portion of the fluid port 10 to secure the coupler 110 to the fluid port. The clips 112 are located on both sides of the housing 102 and engage with both sides of the fluid port 10. The housing 102 includes a living hinge 116 that connects each clip 112 to the rest of the housing (e.g., the central body). The living hinge 116 allows each clip 112 to bend elastically so that the coupler can be attached to and detached from the fluid port. The living hinge 116 biases the retainer 114 toward each other so that the port connector 100 is not unintentionally detached from the fluid port 10. Each clip 112 includes a finger tab 118 configured to be engaged by the user to bend the clip or rotate it around the living hinge 116. Other configurations of the coupler are within the scope of this disclosure. The housing 102 may also include one or more port guides 120 configured to engage with the fluid port 10 to help center the port connector 100 on the fluid port. In the illustrated embodiment, the housing 102 includes two port guides 120 positioned between two clips 112 on both sides of the housing 102 so as to engage with both sides of the fluid port 10. The opposing inner surfaces of the port guides 120 can engage with the fluid port 10 to facilitate the positioning of the port connector 100 on the fluid port 10. The housing 102 may be a single piece or may be multiple pieces fixed to each other. The guide 120 and / or clip 112 (broadly speaking, the port connector 100) define a space that is dimensioned and formed to receive the end of the fluid port 10.

[0016] Referring to Figures 3, 5, and 6, the port connector 100 includes a seal or gasket 122 (broadly speaking, a fluid port interface member). The gasket 122 is supported by the housing 102 (e.g., connected to the housing 102). As shown in Figure 3, the gasket 122 is supported by the housing 102 such that the gasket is partially separated from the fluid port 10 when the housing is coupled to the fluid port. Specifically, the gasket 122 is positioned facing and adjacent to the distal end face 14 of the fluid port 10 when the port connector 100 is attached to the fluid port. The guide 120 may also function as a stopper that engages with the fluid port 10 to position the gasket 122 adjacent to the distal end face 14 (e.g., longitudinal or proximal position). Once the port connector 100 is attached to the fluid port 10, the port connector 100 (e.g., the gasket 122) does not form a fluid sealing seal together with the fluid port. This allows the sterilizing fluid in the environment surrounding the fluid port 10 of the article to come into contact with and sterilize the surface of the fluid port (e.g., end face 14) that would otherwise be blocked or covered when the port connector 100 engages with the fluid port to form a fluid seal.

[0017] The port connector 100 forms a fluid seal together with the fluid port 10 when negative pressure (i.e., a negative pressure difference) is applied to the lumen 12 of the fluid port via a negative pressure source. This allows a fluid (e.g., a sterilization fluid) to be drawn through the fluid port 10 into the internal lumen of the article for sterilization. The gasket 122 is configured to move toward the fluid port 10 and engage with the fluid port 10 when negative pressure is applied from the negative pressure source to draw the fluid through the fluid port, thereby forming a fluid seal. As used herein, the term “fluid seal” refers to a seal that provides sufficient obstruction to the fluid flow so that the fluid can flow from another area (e.g., to the end of the internal lumen of the article opposite the fluid port) as a result of the pressure difference, and does not require an absolute fluid seal that prevents the fluid from passing through. For example, the fluid seal between the gasket 122 and the fluid port 10 must form a sufficient obstruction to the fluid flow between the gasket 122 and the fluid port 10 so that the fluid is drawn into the internal lumen(s) of the article and through the fluid port(s) into the port connector 100. During operation, preferably, the gasket 122 forms an absolute fluid seal with the fluid port 10 so that the fluid cannot pass between the gasket 122 and the fluid port 10, although such an absolute fluid seal is not required for the operation of the port connector 100. As used herein, the term “negative pressure” means a pressure lower than the pressure of the environment surrounding a relative component to which negative pressure is applied, such as the port connector 100. For example, applying negative pressure to the port connector 100 from a negative pressure source means that the negative pressure source applies a pressure lower to the port connector than the pressure of the environment surrounding the port connector (e.g., the chamber of the sterilization system in which the port connector is located). In other words, negative pressure creates a negative pressure difference between the environment surrounding the relative components and the negative pressure source, thereby causing the fluid to flow from the environment towards the negative pressure source. The negative pressure can be a pressure above atmospheric pressure or a pressure below atmospheric pressure (vacuum). In certain preferred embodiments, the negative pressure is lower than atmospheric pressure (vacuum).

[0018] In the illustrated embodiment, the gasket 122 includes a flange 124. The flange 124 is flexible (e.g., elastically flexible). The flange 124 is ring-shaped. The flange 124 is configured to move toward the fluid port 10 (as indicated by the arrow in Figure 3) to engage with the fluid port 10 (e.g., end face 14) to form a fluid seal together with the fluid port due to the application of negative pressure. The flange 124 is positioned adjacent to the end face 14 of the fluid port 10 when the port connector 100 is attached to the fluid port. For example, the flange 124 may be spaced only a few millimeters away from the end face 14. As a result, when negative pressure is applied by a negative pressure source, the negative pressure (e.g., a sufficient pressure difference across the entire flange 124) causes the flange to bend and engage with the end face of the fluid port 10, forming a fluid seal. In one embodiment, the pressure difference between the negative pressure source and the environment surrounding the article may be about 1 / 100, but other differences are also within the scope of this disclosure. The flange 124 preferably extends radially outward from a portion of the housing 102 adjacent to the flange, such that the radially outward portion of the flange (e.g., the distal surface) is exposed to the environment to increase the effect of the pressure difference on the flange. The flange 124 may include a bent section 126 where most of the flange bending occurs. In the illustrated embodiment, the bent section is adjacent to the radially inward edge of the flange 124 and has a thickness thinner than the thickness of the more radially outward portion of the flange. Thus, a weak point of the flange 124 is formed, allowing the flange to bend around it. The flange 124 is elastically deformable so that, as the pressure difference approaches (or becomes) equilibrium, the flange 124 returns to its undeformed or unbent state, as shown in Figure 3. For example, the flange 124 may be designed to return to its unbent state when the pressure difference is about half of the pressure difference initially applied by the negative pressure source. Thus, the flange 124 can be configured to detach from the fluid port 10 and break the fluid seal over a specific pressure difference or range of pressure differences.

[0019] During operation, to sterilize an article having a fluid port 10, the port connector 100 is connected to the fluid port. As previously mentioned, the gasket 122 is separated from the fluid port 100 when the port connector is first connected to the fluid port 10 (e.g., before the fluid seal is formed). A negative pressure source is fluid-connected to the port connector 100 (e.g., outlet 106). The article with the fluid port 10 is placed inside a chamber (e.g., a washing chamber). A fluid (e.g., a sterilization fluid) is supplied or introduced into the chamber. The fluid can remain inside the chamber for a period of time, such as 5-10 minutes, before negative pressure is applied. During this time, the fluid can move naturally or be forced to move around the chamber, coming into contact with the surface of the article and the fluid port, e.g., the surface that is blocked or covered when the port connector 10, together with the fluid port, forms a fluid seal, and thus sterilizing the surface. The operator then applies negative pressure via the negative pressure source. As a result, a fluid seal is formed between the port connector 100 and the fluid port 10 (e.g., end face 14) by moving the gasket 122 (e.g., flange 124) toward the fluid port and engaging it with the fluid port. As described above, the fluid seal is formed by bending the flange 124. Furthermore, the application of negative pressure causes the fluid to move (e.g., draw in) through the internal lumen of the article via the fluid port 10 and port connector 100, thereby sterilizing the inside of the article. Therefore, even if the port connector 100 is attached to the fluid port 10 during the sterilization process, the entire fluid port is generally exposed to the sterilizing fluid and sterilized at some point.

[0020] Referring to Figures 7 to 14, other embodiments of the port connectors relating to this disclosure are shown collectively by reference numeral 200. The port connectors 200 in Figures 7 to 14 are generally similar to the port connectors 100 in Figures 1 to 6, and therefore, for ease of understanding, higher reference numerals "100" are used when similar, similar, or identical parts are used. Accordingly, unless otherwise specified or indicated, the above description relating to the port connectors 100 in Figures 1 to 6 also applies to the port connectors 200 in Figures 7 to 14.

[0021] In this embodiment, the housing 202 includes a piston or plunger 230, a connector body 232, a sleeve or slide 234, and a cap 236. The cap 236 defines an outlet 206 and is configured to be coupled to a fluid conduit or tube to fluidly couple the outlet to a negative pressure source. The plunger 230 defines an insertion portion 203 and an inlet 204. A gasket 222 is supported by the plunger 230. The connector body 232 defines a longitudinal hole 238 extending through the connector body 232. The plunger 230 is movably (e.g., slidably) positioned within the longitudinal hole 238. The port connector 200 may include a seal 240, such as an O-ring, positioned between the plunger 230 and the connector body 232 to prevent fluid flow between the plunger and the connector body. In the illustrated embodiment, the seal 240 can also function as a stopper, engaging with the plunger 230 to restrict the distal movement of the plunger relative to the connector body 232. The slide 234 is supported (e.g., mounted on) the connector body 232 in a movable (e.g., sliding) manner by the connector body 232. The slide 234 has a circumferential wall 242 that surrounds and moves relative to the cylindrical portion of the connector body 232. Thus, the circumferential wall 242 defines a cavity that is dimensioned and formed to receive the distal end of the connector body 232. The port connector 200 may include one or more seals 244, such as O-rings, positioned between the slide 234 (e.g., the circumferential wall 242) and the connector body 232 (e.g., the cylindrical portion) to prevent fluid flow between the slide and the connector body. One or both of the slide 234 and the connector body 232 may define a groove that is dimensioned and formed to receive a portion of the seal 240. In the illustrated embodiment, the connector body 232 defines the groove. The cap 236 is fixed to the slide 234 (for example, at the distal end of the slide). The slide 234 and the plunger 230 are operably coupled to each other such that movement of the slide results in movement of the plunger. In the illustrated embodiment, the plunger 230 is fixed directly to the slide 234.Slide 234 defines a plunger recess 258 (Figure 13) which is formed to be dimensioned to receive the distal end of the plunger 230.

[0022] The plunger 230, connector body 232, slide 234, and cap 236 define the fluid passage 208. That is, the plunger 230, connector body 232, slide 234, and cap 236 each define a portion of the fluid passage 208. Referring to Figure 9, the portion of the fluid passage 208 defined by the plunger 230 includes one or more plunger openings 246 and a plunger passage (e.g., an elongated hole) 248. The plunger passage 248 extends between the inlet 204 and the plunger opening 246, fluid-couples the inlet 204 to the plunger opening. In the illustrated embodiment, the plunger 230 defines two plunger openings 246 on either side of the plunger. The fluid passage 208 includes a fluid chamber 250 defined by the housing 202. One or more plunger openings 246 are in fluid communication with the fluid chamber 250 (e.g., directly). As will be described in more detail below, the fluid chamber 250 is configured to collapse or decrease in volume due to the application of negative pressure (i.e., negative pressure difference). The fluid chamber 250 is at least partially defined by the connector body 232 and the slide 234. Specifically, the fluid chamber 250 is partitioned by the distal end of the connector body 232, the plunger 230, the peripheral wall 242, and the separation wall 252 of the slide 234. A portion of the fluid passage 208 defined by the slide 234 includes at least one slide passage 254 (Figure 13). The slide passage 254 fluid-couples the fluid chamber 250 to the outlet 206. In the illustrated embodiment, the slide 234 includes four slide passages 254. The slide 234 and the cap 236 define the outlet chamber 256 (Figure 8), which is fluid-coupled to the outlet 206. The sliding passage 254 extends between the outlet chambers 256 and the fluid chamber 250 on either side of the separation wall 252, and fluidly connects them.

[0023] The plunger 230 is configured to move along the longitudinal hole 238 toward or proximal to the fluid port 10 when a pressure difference (i.e., negative pressure) is applied, moving the gasket 222 toward the fluid port 10 (e.g., end face 14) so ​​that the gasket engages with the fluid port and forms a fluid seal together with the fluid port. Specifically, the slide 234 moves proximal to the connector body 232 due to the application of negative pressure from the negative pressure source, substantially reducing (e.g., compressing) the volume of the fluid chamber 250 (Figure 10). As a result of the proximal movement of the slide 234, the plunger 230 moves proximal (from the initial position shown in Figure 9) to move the gasket toward the fluid port so that the gasket 222 engages with the fluid port 10 (e.g., end face 14) and forms a fluid seal together with the fluid port. Figure 10 shows the gasket 222 in the sealing position, forming a fluid seal together with the fluid port 10 after the application of negative pressure. Preferably, the gasket 22, together with the fluid port 100, forms an absolute fluid seal. To facilitate the collapse of the fluid chamber 250, the combined cross-sectional area of ​​one or more slide passages 254 is larger than the combined cross-sectional area of ​​the plunger opening 246. This configuration restricts the fluid flow in the plunger opening 246 (compared to the slide passages 254), thereby facilitating the formation of a local negative pressure within the fluid chamber 250 sufficient to move the slide 234 proximal. Preferably, the plunger opening 246 is configured such that it remains in fluid communication with the fluid chamber 250 when the plunger is moved proximal. In the illustrated embodiment, the distal end of the connector body 232 also includes a chamfer or inclined surface 260 at the distal end of the longitudinal hole 238, which keeps the plunger opening 246 in fluid communication with the fluid chamber 250 when the plunger is moved proximal (e.g., in the sealed position).

[0024] In the illustrated embodiment, the elasticity (e.g., flexibility) of the gasket 222, the weight of the slide 234 and cap 236, and the weight of the fluid conduit attached to the cap 236 generally maintain the slide and plunger 230 in their initial position (Figure 9) before negative pressure is applied when the coupler 210 (e.g., clip 212, port guide 220) is attached to the fluid port 10. In one embodiment, the port connector 200 may include a spring (e.g., a coil spring) that can bias the slide 234 and plunger 230 distally in their initial position.

[0025] Referring to Figure 14, the plunger 230 is substantially cylindrical. The plunger 230 defines a groove 262 in which the gasket 222 is positioned. The groove 262 is distally defined by a radial or circumferential flange 264. The flange 264 supports the gasket 222 when it engages with the fluid port 10. The flange 264 is also positioned to engage with the connector body 232, more specifically the seal 240, to restrict the distal movement of the plunger 230 (for example, to position the plunger and slide 234 in their initial positions).

[0026] Referring to Figure 8A, a version of the port connector without seals 240, 244 is shown collectively by reference number 200'. The port connector 200' in Figure 8A is similar to the port connector 200 in Figure 8, and similar, analogous, or identical elements are given the same reference number with a trailing prime added. In this embodiment, the clearance between the outer surface of the connector body 232' and the inner surface of the slide 234' is very small, thereby forming an ultra-low leakage, low friction interface between the connector body and the slide, allowing the slide to move relative to the connector body. Similarly, the clearance between the inner surface of the connector body 232' defining the longitudinal hole 238' and the outer surface of the plunger 230' is also very small, again forming an ultra-low leakage, low friction interface between the connector body and the plunger, allowing the plunger to move relative to the connector body. The low-leakage interfaces between these components are sufficient to provide sufficiently large resistance to fluid flow between them, so that when negative pressure is applied to the port connector 200', the slide 234' and plunger 230' move to the sealed position in the proximal direction, drawing fluid through the fluid port 10 as described herein in relation to the port connector 200 in Figure 8. This occurs despite any fluid that could flow along these low-leakage interfaces. Thus, the port connector 200' in Figure 8A generally functions and operates similarly to the port connector 200 in Figure 8.

[0027] During operation, the port connector 200 is connected to the fluid port 10 to sterilize an article having the fluid port 10. As previously mentioned, the gasket 222 is separated from the fluid port 10 when the port connector 200 is first connected to the fluid port (e.g., before the fluid seal is formed). A negative pressure source is fluid-connected to the port connector 200 (e.g., outlet 206). The article with the fluid port 10 is placed inside a chamber (e.g., a washing chamber). A fluid (e.g., sterilization fluid) is supplied or introduced into the chamber. The fluid can remain inside the chamber for a period of time, such as 5-10 minutes, before negative pressure is applied. During this time, the fluid can move naturally or be forced to move around the chamber, coming into contact with the surface of the article and the fluid port, e.g., the surface that is blocked or covered when the port connector 10, together with the fluid port, forms a fluid seal, and sterilizing that surface. The operator then applies negative pressure via the negative pressure source. As a result, a fluid seal is formed between the port connector 200 and the fluid port 10 (e.g., end face 14) by moving the gasket 222 toward the fluid port and engaging it with the fluid port when connected by each clip 212 (e.g., retainer 214) to the fluid port. As previously mentioned, moving the gasket 222 involves moving the plunger 230 and the slide 234. Specifically, the application of negative pressure creates a vacuum in the fluid chamber 250 that moves the slide 234 proximal to the connector body 232. Furthermore, the application of negative pressure moves the fluid through the fluid port 10 and the port connector 200 to the internal lumen of the article (e.g., draw-in), thereby sterilizing the inside of the article.

[0028] Referring to Figures 15-17, other embodiments of the port connectors relating to this disclosure are shown collectively by reference numeral 300. The port connectors 300 in Figures 15-17 are generally similar to the port connectors 100 in Figures 1-6, and therefore, for ease of understanding, higher reference numerals "200" are used where similar, similar, or identical parts are used. Accordingly, unless otherwise specified or indicated, the above description relating to the port connectors 100 in Figures 1-6 also applies to the port connectors 300 in Figures 15-17.

[0029] The port connector 300 of this embodiment includes a porous member 322 (broadly speaking, a fluid port interface member). The porous member 322 is supported by a housing 302. In the illustrated embodiment, the porous member 322 is fitted into an insertion portion 303. As shown in Figure 17, the porous member 322 is positioned relative to the housing 302 to engage with the fluid port 10 when the port connector 300 is connected to the fluid port. Specifically, the porous member 322 is positioned to engage with the distal end (specifically, the distal end face 14) of the fluid port 10. The porous member 322 has a porous structure that defines a plurality of randomly arranged interconnected gap spaces, the gap spaces forming a plurality of micro-passages 321 that penetrate and / or are located within the porous member. The porous member 322 is positioned to engage with the distal end face 14 of the fluid port 10 when the port connector 300 is attached to the fluid port. The porous member 322 is positioned relative to the housing 302 such that at least a portion of its micro-passages fluid-couples the fluid port outlet 16 to the external environment of the port connector 300 when the port connector is connected to the fluid port 10. Thus, when the port connector 300 is attached to the fluid port 10, the porous member 322 does not form an absolute fluid seal together with the fluid port. Instead, fluid can move through the porous member 322 via the micro-passages 321. However, as will be described in more detail below, the porous member 322 sufficiently obstructs the flow of fluid through the fluid port 10 so that fluid flows from other areas (e.g., to the end of the internal lumen of the article opposite the fluid port) as a result of a pressure difference, so the port connector 300 can still be considered to form a fluid seal (as defined herein) together with the fluid port.

[0030] The porous member is preferably made of a biocompatible, hydrophobic, and / or non-flammable material. In one embodiment, the porous member is formed from expanded polyterafluoroethylene (ePTFE), such as FluroFlex® ePTFE, but other suitable materials are also within the scope of this disclosure. In one embodiment, the porous member has a density of about 0.3 to 0.6 g / cm³. 3Within the comprehensive range, or more preferably about 0.4 to 0.5 g / cm³ 3 It may have a density within its comprehensive range.

[0031] In one embodiment, as shown in the figure, the microchannels 321 of the porous member 322 are arranged substantially randomly throughout the porous member. In one embodiment, a porous control material or coating 325 (Figure 17A) is applied to the porous member 322. For example, the porous control material 325 may be applied to one or more surfaces (e.g., the outer surface) of the porous member 322. The porous control material 325 may be applied to the entire surface of the porous member 322 or to only a portion of the surface. The porous member 322 may be fitted with or covered with the porous control material 325. By applying the porous control material 325 to one or more surfaces of the porous member 322, the flow path can be defined through the porous member rather than relying on the randomness of the microchannels 321. The porous control material 325 controls how and where the sterilization fluid flows through the porous member by at least partially blocking at least a portion of the microchannels 321 of the porous member 322. The porous control material 325 may completely block the microchannels 321, or it may only partially block the microchannels to which the porous control material is aligned (e.g., a cover). The porous control material 325 may also increase the resistance to the flow of sterilization fluid through the porous member 322 in order to allow an appropriate amount of sterilization fluid to be drawn through the article. Preferably, the resistance to the flow of sterilization fluid through the article and the porous member 322 is relatively similar in order to allow the sterilization fluid to be drawn through both the porous member and the article when a pressure difference is applied by the sterilizer. By applying the porous control material 325 to the porous member 322, the fluid path through the porous member closest to or in contact with the fluid port 10 (e.g., the surface of the fluid port) (through the microchannels 321) can be more easily defined, making it more certain that the sterilization fluid will come into contact with the fluid port as it flows through the porous member. For example, in one embodiment, the porous control material 325 is spaced away from the portion of the porous member that is in contact with the fluid port 10. The porous control material 325 may be non-porous or may have a porosity smaller than that of the porous member 322. The porous control material 325 can be made from any suitable material such as polyterafluoroethylene (PTFE).

[0032] Referring further to Figure 17, the porous member 322 is positioned relative to the housing 302 such that when the port connector 300 is connected to the fluid port 10, the porous member covers a portion (broadly speaking, at least a portion) of the fluid port outlet 16. The porous member 322 includes an engaging surface 323 positioned to engage with the distal end (e.g., distal end face 14) of the fluid port 10. The engaging surface 323 generally faces proximal. In the illustrated embodiment, the engaging surface 323 has a substantially annular shape to coincide with the substantially annular end of the fluid port. The inner diameter ID (Figure 17A) of the engaging surface 323 is smaller than the diameter D of the fluid port outlet 16. Similarly, the engaging surface 323 has an outer diameter OD (Figure 17A) that is larger than the diameter D of the fluid port outlet 16. In one embodiment, the porous member 322 has a substantially donut shape.

[0033] The porous member 322 allows sterilization fluid in the environment surrounding the fluid port 10 of an article to come into contact with the surface of the fluid port (e.g., end face 14) and sterilize it. When a negative pressure differential force is applied to the port connector 300 via a negative pressure source, the sterilization fluid moves (e.g., is drawn in) through the porous member 322 (specifically, through at least some of the micro-passages 321). Some of these micro-passages 321 lead to and / or along the portion of the fluid port 10 (e.g., end face 14) with which the porous member 322 engages. As a result, as the sterilization fluid passes through the porous member 322, the sterilization fluid comes into contact with the fluid port 10, such as the end face 14, thereby sterilizing the portion of the fluid port with which the porous member engages.

[0034] In this embodiment, the housing 302 includes a plurality of port guides 320 configured to engage with the fluid port 10 to align a porous member 322 with the end of the fluid port. In the illustrated embodiment, the housing 302 includes six port guides 320, three of which are located on one side of the housing and three of which are located on the opposite side of the housing. Each port guide 320 has a fin or flange including an inner edge that engages with the fluid port 10 to facilitate the positioning of the port connector 300 on the fluid port 10. The inner edge of each port guide 320 is contoured or molded to match the external shape of the fluid port 10. The port guides 320 also function as stoppers to position the port connector 300 relative to the fluid port 10 (for example, longitudinally or proximal).

[0035] During operation, a port connector 300 is connected to the fluid port 10 to sterilize the article having the fluid port 10. As previously mentioned, the porous member 322 engages with the end of the fluid port 10 (e.g., the distal end face 14). The negative pressure source of the sterilizer is fluidly connected to the port connector 300 (e.g., the outlet 306). The article with the fluid port 10 is placed in a chamber (e.g., a washing chamber). Fluid (e.g., sterilization fluid) is supplied or introduced into the chamber. The fluid can remain in the chamber for a period of time, such as 5 to 10 minutes, before negative pressure is applied. During this time, the fluid can move naturally or be forced to move around the chamber, coming into contact with the surface of the article and the fluid port, such as exposed surfaces, and sterilizing those surfaces. The fluid can also move into and through the porous member 322. The operator then applies a differential pressure (e.g., a negative pressure difference) via the negative pressure source. As a result, the negative pressure difference moves (e.g., draws in) the sterilization fluid from the chamber into the lumen 12 of the fluid port 12 through the porous member. As the sterilization fluid moves through the micro-passages 321 of the porous member 322, it comes into contact with the distal end face 14 (and other surfaces engaged by the porous member), thereby sterilizing the distal end face of the fluid port 10. Furthermore, the negative pressure difference moves (e.g., draws in) the sterilization fluid into the internal lumen of the article through the fluid port 10 and the port connector 100, thereby sterilizing the inside of the article. The movement of the sterilization fluid through the article and the porous member 322 generally occurs simultaneously. The sterilization fluid drawn in through the article and the porous member 322 is then drawn in through the port connector 300 and moves towards the negative pressure source. Therefore, even if the port connector 300 is attached to the fluid port 10 during the sterilization process, the entire fluid port is generally exposed to the sterilization fluid and sterilized.

[0036] Referring to Figures 18–23, another embodiment of the port connector according to this disclosure is shown collectively by reference no. 600. The port connector 600 is shown attached to a fluid port 20 of an article (not shown), such as an endoscope. Other configurations of the fluid port are within the scope of this disclosure. The port connector 600 is used to connect a fluid port 20 of an article or device to be sterilized (by a sterilizing fluid) to a pressure source (e.g., a negative pressure source and / or a positive pressure source) of a sterilization system or apparatus (not shown), such as the sterilization system described in International Publication No. 2018 / 090133. The pressure source creates a pressure difference to sterilize the inner surface (e.g., the internal lumen) of the article by moving the fluid (e.g., sterilizing fluid) through the fluid port 20 and the port connector 600 from the environment surrounding the article into the internal lumen of the article. The pressure source can be any suitable pressure source, such as a vacuum, a pump, or a chamber with a lower / higher pressure than the environment surrounding the article.

[0037] The port connector 600 includes a housing 602. The housing 602 has a proximal end and a distal end. The proximal end defines an inlet 604 configured to fluidly couple to a fluid port. The inlet 604 is formed to be dimensioned to receive at least a portion (e.g., the distal portion) of the fluid port 20. In the illustrated embodiment, the inlet 604 is an elongated hole. Preferably, the portion of the housing 602 defining the inlet 604 does not engage with the fluid port 20. The distal end (e.g., the distal port) defines an outlet 606 configured to fluidly couple to a pressure source. In the illustrated embodiment, the distal end is configured to be coupled to a fluid conduit or tube to fluidly couple the outlet 606 to a pressure source. The inlet 604 and the outlet 606 are fluidly coupled to each other. The housing 602 defines a fluid passage 608 that extends between the inlet 604 and the outlet 606 and fluidly couples them. The housing 602 is configured to be coupled to the fluid port 20. In the illustrated embodiment, the housing 602 consists of a plurality of components fixed to one another. The housing 602 can be made of any suitable material, such as plastic (e.g., polypropylene).

[0038] The port connector 600 includes a seal or gasket 610 (broadly speaking, a fluid port interface member). The seal 610 is supported by (e.g., connected to) the housing 602. In particular, the seal 610 is positioned along the inlet 604. The seal 610 is configured to engage with the fluid port 20. As will be described in more detail below, the seal 610 is configured to move from a first location or position on the fluid port 20 to a second location or position on the fluid port. The seal 610 engages with the fluid port 20 to block the flow of fluid between the seal and the fluid port. Preferably, the seal 610 together with the fluid port 20 forms an absolute fluid seal. In the illustrated embodiment, the seal 610 is an O-ring. The housing 602 includes a groove 612 (e.g., a circumferential groove) in which the seal 610 is positioned. The seal 610 extends inward (e.g., radially inward) from the inner surface defining the inlet 610 to engage with the fluid port 20. Seal 610 can be made from any suitable material such as thermoplastic elastomer (TPE) (e.g., styrene-ethylene-butylene-styrene (SEBS)).

[0039] The port connector 600 includes a piston or plunger 614. The plunger 614 is movably (e.g., slidably) positioned within the housing 602. The plunger 614 is positioned within the fluid passage 608. The plunger 614 includes a flange 618 and a shaft 616 extending proximal to the flange. The flange 618 has a substantially conical shape. The flange 618 tapers outward (e.g., radially outward) as it extends distally from the shaft 616. The outer edge of the flange 618 (broadly speaking, the plunger 614) includes one or more slots 620. The slots 620 are configured to allow fluid flow around the plunger 614. As will be described in more detail below, the slots 620 allow fluid flow from the inlet 604 to the outlet 606. The plunger 614 can be made of any suitable material such as plastic (e.g., polyethylene, polypropylene, polytetrafluoroethylene).

[0040] The plunger 614 is configured to move within the housing 602 from an initial position (Figures 19 and 20) to a second position (Figures 21 and 22). The plunger 614 moves proximal or toward the fluid port from the initial position to the second position (and distally from the second position back to the initial position). In the initial position, the plunger 614 (and the housing 602) are configured to allow fluid to flow between the inlet 604 and the outlet 606. As shown in Figure 20, the housing 602 defines a plunger recess 622. When the plunger 614 is in the initial position, the outer edge of the flange 618 is aligned with the plunger recess 622 (for example, laterally aligned). In some embodiments, the plunger recess 622 may be formed to be dimensioned to receive the outer edge of the flange 618. The plunger recess 622 provides clearance between the outer edge of the flange 618 and the inner surface of the housing 602, allowing fluid to flow around the plunger (e.g., the flange) towards the outlet 606 through the plunger recess 622 and the slot 620. In the illustrated embodiment, the flange 618 engages with the distal inner surface 624 of the housing 602 when the plunger is in its initial position. The distal inner surface 624 acts as a stopper, restricting the distal movement of the plunger 614 relative to the housing 602 and positioning the plunger in its initial position. In the initial position, the plunger 614 is preferably spaced away from the fluid port 20. In the second position, as the plunger moves proximal toward the second position, the outer edge of the flange 618 engages with the inner surface of the housing 602. This engagement forms a seal between the plunger 614 and the housing 602, preventing or blocking the flow of fluid between the plunger and the housing.

[0041] The fluid passage 608 includes a fluid chamber 626. The fluid chamber is defined by a plunger 614 (e.g., flange 618) and a housing 602. As will be described in more detail below, the fluid chamber 626 is configured to expand or increase in volume due to the application of positive pressure (i.e., positive pressure difference) from a pressure source (when the plunger 614 is in its initial position). The fluid chamber 626 is also configured to collapse or decrease in volume due to the application of negative pressure (i.e., negative pressure difference) from a pressure source (when the plunger 614 is in a second position). As used herein, the term “positive pressure” means a pressure higher than the pressure in the environment surrounding a relative component to which positive pressure is applied, such as a port connector 600. For example, applying positive pressure to a port connector 600 from a pressure source means that the pressure source is applying a higher pressure to the port connector than the pressure in the environment surrounding the port connector (e.g., the chamber of the sterilization system in which the port connector is located). In other words, positive pressure creates a positive pressure difference between the environment surrounding the relative components and the pressure source, thereby causing the fluid to flow from the pressure source towards the environment. Positive pressure can be a pressure greater than or equal to atmospheric pressure or a pressure less than atmospheric pressure (vacuum). In certain preferred embodiments, the positive pressure is greater than or equal to atmospheric pressure.

[0042] The plunger 614 is configured to press against the fluid port when positive pressure is applied from a pressure source, moving the housing 602 and seal 610 distal to the fluid port 20, thereby moving the seal to a second location or position on the fluid port. Specifically, the plunger 614 moves proximal to the housing 602 due to the application of a pressure difference (i.e., positive pressure), expanding the fluid chamber 626 and pressing against the fluid port 20. Thus, the plunger 614 engages with the fluid port 20 when the plunger moves from its initial position to a second position. Generally, the plunger 614, together with the housing 602, forms a seal (e.g., a fluid sealing seal) as the plunger moves proximal from its initial position until positive pressure is applied from the pressure source, thereby blocking the flow of fluid between the inlet 604 and the outlet 606. The plunger recess 622 and slot 620 provide sufficient restraint to the fluid flow so that the positive pressure moves the plunger proximal to the surface, causing the flange 618 to engage with the inner surface of the housing when positive pressure is applied.

[0043] By moving the plunger 614, the seal 610 on the fluid port 20 is moved, so that a portion of the fluid port at a first position (otherwise, which would have been blocked or covered by the seal 610 when the port connector 600 was first coupled to the fluid port) is exposed to the fluid in the environment surrounding the fluid port of the article, and comes into contact with and sterilizes a portion of the surface at the first position. As will be described later, it is understood that a portion of the surface at a second position is pre-sterilized by the fluid when the fluid is first drawn in through the port connector 600. The plunger 614 is also configured to move distally toward its initial position after the plunger has pressed against the fluid port 20, thereby reducing the volume of the fluid chamber 626 when negative pressure is applied from a pressure source (e.g., by crushing or contracting).

[0044] In the illustrated embodiment, the distal portion of the inlet 604 is tapered (for example, tapering radially inward as the inlet extends proximal). The plunger 614 (for example, the tip of the shaft 616) is dimensioned and formed to move along the inlet 604. The taper of the inlet 604 helps guide the plunger 614 to engage with the fluid port 20. Furthermore, preferably, the taper of the inlet 604 reduces the size of the inlet so that as the plunger moves proximal, the plunger eventually engages with a portion of the housing 602 that defines the inlet, thereby stopping further movement. Thus, this portion of the housing 602 restricts the proximal movement of the plunger 614 and acts as a stopper for positioning the plunger in a second position.

[0045] During operation, the port connector 600 is connected to the fluid port 20 to sterilize an article having the fluid port 20. Once connected, the seal 610 engages with the fluid port 20 in a first position. A pressure source is fluid-connected to the port connector 600 (e.g., outlet 606). The article with the fluid port 20 is placed inside a chamber (e.g., a washing chamber). A fluid (e.g., sterilization fluid) is supplied or introduced into the chamber. The fluid can remain inside the chamber for a period of time, such as 5-10 minutes, before negative pressure is applied. During this time, the fluid can move naturally or be forced to move around the chamber, coming into contact with the surface of the article and the fluid port to sterilize those surfaces. The operator then applies negative pressure via the pressure source. The application of negative pressure causes the fluid to move (e.g., draw in) through the fluid port 20 and the port connector 600 into the internal lumen of the article, thereby sterilizing the inside of the article. The fluid flows from the inlet 604 through the plunger recess 622 and slot 620 around the plunger 614 and into the outlet 606. Once the fluid enters the inlet 604, it flows across a second position on the fluid port 20. After a sufficient amount of fluid has been drawn through the article, the operator can apply positive pressure via a pressure source. As a result of the application of positive pressure, the seal 610 moves from a first position to a second position along the fluid port 20. As previously mentioned, the application of positive pressure moves the plunger 614 relative to the housing 602 in order to move the seal 610. Specifically, the application of positive pressure expands the fluid chamber 626, pressing the plunger into contact with the fluid port 20. When the plunger 614 contacts the fluid port 20, the continuous application of positive pressure continues to expand the fluid chamber 626 by moving the housing 602 (and therefore the seal 610) distal to the plunger (this prevents further proximal movement by engaging with the fluid port). In one operation, the movement of the plunger 614 disengages or unengages the port connector 600 (e.g., the seal 610) from the fluid port 20.Specifically, the plunger 614 moves the seal 610 not only to a second position, but also by sliding the seal away from the distal end of the fluid port until the seal is no longer engaged with the fluid port 20. Alternatively, after applying positive pressure, the operator can apply negative pressure again via a pressure source, thereby moving the plunger 614 distally back to its initial position. The re-application of negative pressure creates a vacuum within the fluid chamber 626 that moves the plunger 614 distal to the housing 602 to its initial position. Once in the initial position, the fluid can once again flow freely around the plunger 614.

[0046] Referring to Figures 24-27, another embodiment of the port connector according to the present disclosure is shown collectively by reference no. 400. As shown in Figures 25 and 26, the port connector 400 is attached to a fluid port 10' of an article (not shown), such as an endoscope, to be sterilized. The fluid port 10' shown in Figures 25 and 26 is substantially the same as the fluid port 10 described above, except that the fluid port 10' does not have any hook-like parts on its exterior. Instead, the fluid port 10' has a substantially smooth cylindrical outer surface.

[0047] The port connector 400 includes a housing 402. The housing 402 has a proximal end and a distal end. The distal end (e.g., the distal port) defines an outlet 406 configured to be fluid-coupled to a negative pressure source (broadly speaking, a sterilizer). In other words, the outlet 406 is positioned to be in fluid communication with the negative pressure source. In the illustrated embodiment, the distal end is configured to be coupled to a fluid conduit or tube to fluid-couple the outlet 406 to the negative pressure source. The distal end includes a tube port fitting with a hooked portion. The housing 406 also defines an inlet 404 configured to be fluid-coupled to the fluid port 10', specifically its lumen 12. In other words, the inlet 404 is positioned to be in fluid communication with the fluid port 10', specifically its lumen 12. The housing 402 defines a fluid passage 408 (e.g., a lumen, a hole) that extends between the inlet 404 and the outlet 406 and fluidly couples them (e.g., providing fluid communication between the inlet 404 and the outlet 406).

[0048] The port connector 400 of this embodiment includes a porous member 422 (broadly speaking, a fluid port interface member). The porous member 422 is coupled to the housing 402. In the illustrated embodiment, the porous member 422 is mounted on the housing 402. The porous member 422 is flexible, deformable, and has a substantially tubular shape. The housing 402 has a cylindrical wall 410. The porous member 422 has a proximal end and a distal end, both of which are coupled to the housing 402. The distal end of the porous member 422 is mounted on the cylindrical wall 410 (for example, the cylindrical wall is located inside the porous member). The cylindrical wall 410 defines a portion of the fluid passage 408. The housing 402 also includes a mounting ring 412. The mounting ring 412 is located on the proximal side of the cylindrical wall 410 and the inlet 404. The proximal end of the porous member 422 is mounted on the mounting ring 412. The connector 400 includes a retaining ring 414 (broadly speaking, a retainer) that secures the porous member 422 (the proximal end of the porous member 422) to the mounting ring 412. In the illustrated embodiment, the porous member 422 is folded over itself so as to be secured to the mounting ring 412. The proximal end of the porous member 422 is bent around the mounting ring 412. The retaining ring 414 then clamps or secures the proximal end of the porous member 422 to the outside of the mounting ring 412. The housing 402 includes one or more supports 416 for supporting the mounting ring 412. The supports 416 extend between the mounting ring 412 and the body of the housing 422, connecting the mounting ring 412 to the body of the housing 422.

[0049] The connector 400 defines a receiving chamber 418. The receiving chamber 418 is formed to be dimensioned to receive a fluid port 10'. The porous member 422 defines at least a portion of the receiving chamber 418. The inlet 404 of the housing 402 is in fluid communication with the receiving chamber 418. The inlet 404 is located in the portion of the receiving chamber 418 defined by the porous member 422. In the illustrated embodiment, the inlet 404 is located substantially adjacent to the distal end of the receiving chamber 418. The receiving chamber 418 includes a port or receiving inlet 420 (Figure 24). The port inlet 420 is formed to be dimensioned to receive a fluid port 10' so that the fluid port can be inserted into the receiving chamber 418. The port inlet 420 is located at the proximal end of the receiving chamber. In the illustrated embodiment, the port inlet 420 is defined by the porous member 422. The porous member 422 defines the proximal end of the port connector 400.

[0050] As shown in Figures 25 and 26, the porous member 422 is positioned to engage with the fluid port 10' when the port connector 400 is connected to the fluid port. Specifically, the porous member 422 (specifically, its interior or engaging surface) is positioned to engage with the fluid port 10' when the fluid port is positioned within the receiving chamber 418. The porous member 422 is positioned to engage with the cylindrical outer surface of the fluid port 10'. Preferably, the porous member 422 is configured to form an interference fit or friction fit with the fluid port 10'. The porous member 422 has an inner diameter at the narrowest point of the receiving chamber 418 (when the porous member is stationary and not bent by the fluid port 10'). The inner diameter is equal to, or more preferably smaller than, the outer diameter of the fluid port 10'. This ensures that the porous member 422 engages with the fluid port 10' and deforms, and that elastic deformation applies force to the fluid port to hold the port connector 400 on it. In other words, the porous member is pressed against the fluid port. Figure 26 shows the porous member 422 in its stationary, undeformed state, but it is understood that the fluid port 10' deforms the porous member by expanding the port inlet 420 and / or the receiving chamber 418 (e.g., part of the receiving chamber) to allow the fluid port to be received by the port connector 400.

[0051] The porous member 422 has a porous structure defining a plurality of randomly arranged, interconnected gap spaces, the gap spaces forming a plurality of micro-passages 421 that penetrate and / or are located within the porous member. The porous member 422 is positioned relative to the rest of the port connector 400 such that at least a portion of the micro-passages 421 fluidly couple the receiving chamber 418 to the external environment of the port connector 400. Thus, when the port connector 400 is attached to the fluid port 10', the porous member 422 does not form an absolute fluid seal with the fluid port. Instead, fluid can move through the porous member 422 via the micro-passages. However, as will be described in more detail below, the porous member 422 sufficiently obstructs the flow of fluid through the fluid port 10' so that fluid flows from other areas (e.g., to the end of the internal lumen of the article opposite the fluid port) as a result of a pressure difference, and the port connector 400 can still be considered to form a fluid seal (as defined herein) with the fluid port 10'. The porous member 422 may be made of the same material as described above for the porous member 322.

[0052] The porous member 422 allows sterilizing fluid in the environment surrounding the fluid port 10' of the article to come into contact with the surface of the fluid port (e.g., end face 14, cylindrical outer surface) and sterilize the surface. When a negative pressure differential force is applied to the port connector 400 via a negative pressure source, the sterilizing fluid moves (e.g., is drawn in) through the porous member 422 (specifically, through at least some of the micro-passages 421). Some of these micro-passages 421 lead to and / or along the portion of the fluid port 10' into which the porous member 422 is engaged. As a result, as the sterilizing fluid moves through the porous member 422, the sterilizing fluid comes into contact with the fluid port 10' and thereby sterilizes the portion of the fluid port engaged by the porous member.

[0053] In one embodiment, as shown in the figure, the microchannels 421 of the porous member 422 are arranged substantially randomly throughout the porous member. In one embodiment, a porous control material or coating 425 (Figure 26) is applied to the porous member 422. For example, the porous control material 425 may be applied to one or more surfaces (e.g., the outer surface) of the porous member 422. The porous control material 425 may be applied to the entire surface of the porous member 422 or to only a portion of the surface. The porous member 422 may be fitted with or covered with the porous control material 425. By applying the porous control material 425 to one or more surfaces of the porous member 422, the flow path can be defined through the porous member rather than relying on the randomness of the microchannels 421. The porous control material 425 controls how and where the sterilization fluid flows through the porous member by at least partially blocking at least a portion of the microchannels 421 of the porous member 422. The porous control material 425 may completely block the microchannels 421, or it may only partially block the microchannels to which the porous control material is aligned (e.g., a cover). The porous control material 425 may also increase the resistance to the flow of sterilization fluid through the porous member 422 in order to allow an appropriate amount of sterilization fluid to be drawn through the article. Preferably, the resistance to the flow of sterilization fluid through the article and the porous member 422 is relatively similar in order to allow the sterilization fluid to be drawn through both the porous member and the article when a pressure difference is applied by the sterilizer. By applying the porous control material 425 to the porous member 422, it is possible to more easily define the fluid path through the porous member (via the microchannels 421) that is closest to or in contact with the fluid port 10' (e.g., the surface of the fluid port), thereby making it more certain that the sterilization fluid will come into contact with the fluid port as it flows through the porous member. For example, in one embodiment, the porous control material 425 is positioned distal to the proximal end of the porous member 422, thereby defining a fluid path that flows along the outer surface of the port 10' to the proximal end of the porous member and into the receiving chamber 418. The porous control material 425 may be non-porous or may have a porosity smaller than that of the porous member 422.The porous control material 425 can be made from any suitable material such as polyterafluoroethylene (PTFE).

[0054] Referring to Figures 26 and 27, the housing 402 includes a stopper 424. The stopper 424 is positioned to engage with the fluid port 10' and position the fluid port within the receiving chamber 418. The stopper 424 is positioned to engage with the distal end 14 of the fluid port 10'. The stopper 424 restricts the distal movement of the fluid port 10' relative to the port connector 400 in the insertion direction. The insertion direction is the direction in which the fluid port 10' moves relative to the port connector 400 when the port connector is connected to the fluid port, i.e., the direction in which the fluid connector is inserted into the port inlet 420. In the illustrated embodiment, the stopper 424 includes a rim positioned to engage with the fluid port 10. The rim is positioned at the proximal end of the cylindrical wall 410. Preferably, the stopper 424 is the only part of the housing 402 positioned to engage with the fluid port 10' to prevent the housing from otherwise obstructing the flow of sterile fluid around the fluid port 10'. Preferably, the stopper 424 allows the sterilization fluid to flow between the stopper and the fluid port 10' when the stopper engages with the fluid port and a pressure difference is applied. Therefore, the narrow edge-shaped engagement of the stopper 424 disclosed herein does not form a seal with the fluid port 10', thereby allowing the sterilization fluid to flow between the stopper and the fluid port. In one embodiment, the stopper 424 may define a recess or channel (not shown) to further facilitate the flow of sterilization fluid between the stopper and the fluid port 10'. In the illustrated embodiment, the stopper 424 defines an inlet 404.

[0055] The port connector 400 may include a port guide 426. The port guide 426 is configured to substantially align the lumen 12 of the fluid port 10' with the inlet 404. The port guide 426 is formed to be dimensioned to receive the lumen 12 of the fluid port 10'. In the illustrated embodiment, a portion of the port guide 426 is positioned in the fluid passage 408. The port guide 426 is mounted on the inner wall of the housing 402 (broadly speaking, the port guide is part of the housing). The inner wall defines one or more openings 428 (Figure 27) that are part of the fluid passage 408, allowing the sterilized fluid to flow through them as the sterilized fluid flows from the inlet 404 to the outlet 406. The port guide 426 extends proximal to the inner wall of the housing 402. The port guide 426 extends through the inlet 404. In the illustrated embodiment, the port guide 426 has a substantially truncated conical shape, but other shapes are also within the scope of this disclosure. The port guide 426 ensures that the fluid port 10' is properly positioned relative to the port connector 400 when the port connector is attached to the fluid port.

[0056] During operation, to sterilize an article having a fluid port 10', the port connector 400 is connected to the fluid port by inserting the fluid port into the receiving chamber 418 through the port inlet 420. As previously mentioned, the porous member 422 engages with the fluid port 10'. The negative pressure source of the sterilizer is fluidly connected to the port connector 400 (e.g., outlet 406). The article with the fluid port 10' is placed inside the chamber (e.g., a washing chamber). Fluid (e.g., sterilization fluid) is supplied or introduced into the chamber. The fluid can remain inside the chamber for a period of time, such as 5-10 minutes, before negative pressure is applied. During this time, the fluid can move naturally or be forced to move around the chamber, coming into contact with the surface of the article and the fluid port, such as exposed surfaces, and sterilizing those surfaces. The fluid can also move into and through the porous member 422. The operator then applies a differential pressure (e.g., a negative pressure difference) via the negative pressure source. As a result, the negative pressure difference causes the sterilization fluid to move (e.g., be drawn in) from the chamber through the porous member into the receiving chamber 418. As the sterilization fluid moves through some of the micro-passages 421 of the porous member 422, it comes into contact with the cylindrical outer surface, thereby sterilizing the portion of the fluid port 10' engaged by the port connector. After the sterilization fluid enters the receiving chamber 418, it moves around the fluid port 10', sterilizing the remaining fluid ports contained in the receiving chamber before the sterilization fluid enters the inlet 404 of the port connector 400. Aligning the inlet 404 with the porous member 422 (e.g., lateral alignment) is thought to result in a more substantial flow of sterilization fluid through the porous member. Furthermore, the negative pressure difference causes the sterilization fluid to move (e.g., be drawn in) through the internal lumen of the article through the fluid port 10' and the port connector 400, thereby sterilizing the inside of the article. The movement of the sterilization fluid through the article and the porous member 422 generally occurs simultaneously. The sterilization fluid drawn in through the articles and porous members 422 is then drawn in through the port connector 400 and moves toward the negative pressure source.Therefore, even if the port connector 400 is attached to the fluid port 10 during the sterilization process, the entire fluid port is generally exposed to the sterilization fluid and sterilized. See other descriptions in this disclosure.

[0057] The following is a description of exemplary embodiments described in this disclosure. Some of the following descriptions are not currently presented as claims, but they are considered patentable and may be presented as claims at a later date. Related methods corresponding to the following descriptions or apparatus or systems are also considered patentable and may be presented as claims at a later date. Similarly, related apparatus or systems corresponding to the following descriptions or methods are also considered patentable and may be presented as claims at a later date. The following descriptions are understood to refer to, and may be supported by, one, more, or all of the embodiments described above.

[0058] A1. A port connector for connecting a fluid port of a device to be sterilized to a negative pressure source of a sterilizer, comprising: a housing configured to be coupled to a fluid port, having a proximal end defining an inlet configured to be fluidly coupled to the fluid port, and a distal end defining an outlet configured to be fluidly coupled to the negative pressure source, and a fluid passage extending between the inlet and the outlet to fluidly couple the inlet and the outlet; and a gasket supported by the housing so as to be separated from the fluid port when the housing is coupled to the fluid port, and configured to move toward the fluid port when negative pressure is applied from the negative pressure source to draw fluid through the fluid port, engage with the fluid port, and together with the fluid port form a fluid sealing seal.

[0059] A2. The port connector of description A1, the proximal end includes an insertion portion that is dimensioned and formed to be inserted into a fluid port, the insertion portion defining the entrance.

[0060] A3. A port connector described in any one of A1 to A2, wherein the gasket includes a flexible flange, the flexible flange being configured to move toward the fluid port due to the application of negative pressure and engage with the fluid port to form a fluid sealing seal together with the fluid port.

[0061] A4. A port connector described in any one of A1 to A2, wherein the housing includes a plunger that supports a gasket, and the plunger is configured to move proximal to the fluid port when negative pressure is applied, thereby moving the gasket toward the fluid port, such that the gasket engages with the fluid port and together with the fluid port forms a fluid-sealed seal.

[0062] A5. A port connector described in any of A1-A4, wherein the fluid passage defined by the housing includes a fluid chamber, and the fluid chamber is configured to collapse substantially due to the application of negative pressure.

[0063] A6. A port connector described in any of A1 to A5, comprising a connector body and a slide movably supported by the connector body, the slide being operably coupled to a plunger such that the movement of the slide results in the movement of the plunger.

[0064] A7. Any one of the port connectors described in A1 to A6, wherein the connector body and slide define at least partially the fluid chamber, and the slide moves proximal to the connector body due to the application of negative pressure, substantially compressing the fluid chamber and moving the plunger proximal, moving the gasket toward the fluid port so that the gasket engages with the fluid port and together with the fluid port forms a fluid sealing seal.

[0065] A8. A port connector described in any one of A1 to A7, wherein the plunger defines an inlet, and the plunger further defines at least one plunger opening that fluidly communicates with a fluid chamber, and an elongated hole that fluidly couples the inlet with at least one plunger opening.

[0066] A9. The slide has one port connector from any of descriptions A1-A8 that defines at least one slide passage for fluid coupling of the fluid chamber to the outlet.

[0067] A10. The housing includes one of the port connectors described in A1-A9, which includes a coupler configured to connect to the fluid port.

[0068] A11. A port connector according to any one of descriptions A1 to A10, comprising a first elastically flexible clip and a second elastically flexible clip, wherein the first and second clips are configured to engage with a fluid port to couple the port connector to a fluid port.

[0069] A12. One of the port connectors described in A1 to A11, each comprising a first and second clip, and a retainer configured to engage with the fluid port to secure the port connector to the fluid port.

[0070] B1. A method for sterilizing a device having a fluid port, comprising the steps of connecting a port connector to a fluid port, wherein the port connector has an inlet that is in fluid communication with the fluid port, an outlet, and a fluid passage that extends between the inlet and the outlet and fluidly connects the inlet and the outlet; fluidly connecting a negative pressure source to the outlet of the port connector; forming a fluid seal between the port connector and the fluid port by moving the gasket of the port connector toward the fluid port and engaging it with the fluid port; and moving a sterilization fluid through the fluid port and the port connector.

[0071] B2. The method of description B2, further comprising the steps of placing a device in a washing chamber and supplying sterile fluid to the washing chamber before moving the sterile fluid.

[0072] B3. Any one of the methods described in B1-B2, wherein the gasket includes a flexible flange, and the fluid sealing is formed by bending the flexible flange to move toward the fluid port and engage with the fluid port.

[0073] B4. A method of any one of descriptions B1 to B3, wherein the port connector includes a plunger that supports a gasket, and the step of forming a fluid-sealed seal includes the step of moving the plunger to move the gasket toward the fluid port and engage with the fluid port.

[0074] B5. A port connector comprising a connector body and a slide movably supported by the connector body, wherein the slide is operably connected to a plunger such that the movement of the slide results in the movement of the plunger, and the step of forming a fluid seal comprises moving the slide relative to the connector body, thereby moving the plunger, and moving the gasket toward the fluid port and engaging with the fluid port, one of the methods described in B1 to B4.

[0075] B6. The connector body and slide define at least partially a fluid chamber of a fluid passage and form a fluid sealing seal, the step of moving the slide relative to the connector body by creating a vacuum in the fluid chamber, thereby substantially crushing the fluid chamber as a result of the vacuum, one of the methods described in B1 to B5.

[0076] B7. The gasket is separated from the fluid port before the step of forming a fluid sealing seal, in any one of the methods described in B1 to B6.

[0077] B8. The port connector includes a coupler for connecting the port connector to the fluid port, in one of the methods described in B1-B7.

[0078] B9. The step of forming a fluid seal is any one of the methods described in B1 to B8, comprising the step of applying negative pressure to the port connector via a negative pressure source.

[0079] B10. The step of moving the sterilization fluid includes drawing the sterilization fluid through the fluid port and port connector by applying negative pressure from a negative pressure source, any one of the methods described in B1 to B9.

[0080] C1. A port connector for connecting a fluid port of a device to be sterilized to a pressure source of a sterilizer, comprising: a housing configured to be coupled to a fluid port, having a proximal end defining an inlet configured to be fluidly coupled to a fluid port, and a distal end defining an outlet configured to be fluidly coupled to a negative pressure source, the inlet being fluidly coupled to the outlet; a seal supported by the housing and configured to engage with the fluid port in a first position; and a piston movably disposed within the housing, configured to press the fluid port when positive pressure is applied from the pressure source to move the housing and seal distal to the fluid port and move the seal to a second position on the fluid port.

[0081] C2. A port connector as described in C1, wherein at least the piston and housing define a fluid chamber, and the fluid chamber is configured to expand as a result of the application of positive pressure.

[0082] C3. The piston moves proximal to the housing due to the application of positive pressure to expand the fluid chamber and press against the fluid port of one of the port connectors described C1-C2.

[0083] C4. The piston is movable from its initial position, and in the initial position, the piston is configured to allow fluid to flow between the inlet and outlet, through one of the port connectors described in C1 to C3.

[0084] C5. The piston is configured to move proximal to the fluid port from an initial position, and the piston, together with the housing, substantially forms a fluid-sealing seal when the piston moves proximal to the outlet to block the flow of fluid between the outlet and the inlet, as described in one of the port connectors C1-C4.

[0085] C6. The piston has one of the port connectors described C1-C5, which includes one or more slots configured to allow fluid flow around the piston.

[0086] C7. The piston is configured to move distally toward its initial position after the piston presses against the fluid port and contracts the fluid chamber when negative pressure is applied from a pressure source, one of the port connectors described in C1 to C6.

[0087] D1. A method for sterilizing a device having a fluid port, comprising the steps of: connecting a port connector to a fluid port such that the seal of the port connector engages with the fluid port in a first position; fluidly connecting a pressure source to the outlet of the port connector; and moving the piston of the port connector relative to the housing of the port connector by applying pressure from the pressure source to move the seal to a second position on the fluid port.

[0088] D2. The method of description D1, wherein the step of moving the piston includes the step of applying positive pressure from a pressure source.

[0089] E1. A port connector for connecting a fluid port of a device to be sterilized to a sterilizer, wherein the fluid port defines a lumen, and the port connector comprises a porous member having a porous structure that defines a plurality of micro-passages, wherein the porous member defines at least a portion of a receiving chamber formed to be dimensioned to receive the fluid port, and the inner surface of the porous member engages with the fluid port when the fluid port is placed in the receiving chamber; and a housing coupled to the porous member, comprising an inlet configured to be fluidly coupled to the lumen of the fluid port, an outlet configured to be fluidly coupled to a sterilizer, and a fluid passage extending between the inlet and the outlet and fluidly coupling the inlet and the outlet, wherein the inlet is located in the at least portion of the receiving chamber defined by the inner surface of the porous member.

[0090] E2. At least a portion of the micro-passages of the porous material fluidly couples the receiving chamber to the external environment of the port connector as described in E1.

[0091] E3. A porous member is configured to form a fluid port and an interlocking fit with one of the port connectors described in E1 to E2.

[0092] E4. A porous member having an inner diameter at the narrowest point of the receiving chamber, and the inner diameter being less than or equal to the outer diameter of the fluid port, one of the port connectors described in any of E1 to E3.

[0093] E5. A port connector having a porous material that is substantially tubular in shape, one of the ports described in E1 to E4.

[0094] E6. The housing includes one of the port connectors described in E1-E5, which includes a stopper that engages with the fluid port and is positioned to position the fluid port within the receiving chamber.

[0095] E7. A stopper restricts the movement of the fluid port relative to the connector in the insertion direction, where the insertion direction is the direction in which the fluid port moves relative to the port connector when the port connector is connected to the fluid port, as described in one of the port connectors E1-E6.

[0096] E8. The stopper is positioned to engage with the distal end of the fluid port, one of the port connectors described in E1-E7.

[0097] E9. A port connector described in any of E1-E8, wherein the stopper includes a rim, and the rim is positioned to engage with the fluid port.

[0098] E10. One of the port connectors described in E1-E9, wherein the only part of the housing positioned to engage with the fluid port is the edge of the stopper.

[0099] E11. A port connector described in any of E1-E10, further comprising a guide configured to align the lumens of the fluid port with the inlet.

[0100] E12. The guide is formed to be dimensioned to fit within the lumen of the fluid port, and is one of the port connectors described in E1 to E11.

[0101] E13. A guide extends through the entrance to one of the port connectors described as E1-E12.

[0102] E14. One of the port connectors described in E1-E13, in which the guide is part of the housing and extends proximal to the inner wall of the housing.

[0103] E15. One of the port connectors described in E1 to E14, wherein a porous material defines the proximal end of the port connector.

[0104] E16. A porous member defines a receiving inlet at the proximal end of the receiving chamber, and the receiving inlet is formed to be dimensioned to receive a fluid port, one of the port connectors described in E1 to E15.

[0105] E17. A port connector described in any of E1 to E16, wherein a porous member has a proximal end and a distal end, and the proximal and distal ends are coupled to a housing.

[0106] E18. A port connector described in any one of E1 to E17, wherein the housing includes a cylindrical wall and a mounting ring, the distal end of the porous member is mounted on the cylindrical wall, and the proximal end of the porous member is mounted on the mounting ring.

[0107] E19. A port connector comprising any one of the descriptions E1 to E18, further comprising a retaining ring, the retaining ring securing the proximal end of the porous member to the mounting ring.

[0108] E20. A port connector described as one of E1-E19, with its proximal end bent around a mounting ring.

[0109] E21. The housing includes one or more supports that support the mounting ring, and one of the port connectors described in E1 to E20.

[0110] E22. A port connector described in any of E1 to E21, which is used in combination with a fluid port and has no hook-shaped portion on its exterior.

[0111] E23. A port connector described in any of E1 to E22, wherein the fluid port has a substantially cylindrical outer surface, and the outer surface is smooth.

[0112] F1. A port connector for connecting a fluid port of a device to be sterilized to a sterilizer, comprising: a housing that defines an outlet configured to be coupled to the fluid port and configured to be fluidly coupled to the sterilizer; a seal disposed together with the fluid port to form a fluid sealing seal; and a piston supported by the housing and movable relative to the housing when a pressure difference is applied by the sterilizer.

[0113] F2. The seal is supported by the piston and moves with the piston when a pressure difference is applied to engage with the fluid port and form a fluid sealing seal together with the fluid port, as described in the port connector of F1.

[0114] F3. A port connector described as F1-F2, wherein the seal is configured to engage with the fluid port in a first position, and the piston is configured to press against the fluid port when a pressure difference is applied to move the seal to a second position on the fluid port.

[0115] It is clear and understood that the elements, features, and / or teachings described in each embodiment disclosed herein are not limited to the specific embodiment in which the elements, features, and / or teachings are described. Accordingly, it is clear and understood that the elements, features, and / or teachings described in one embodiment may be applicable to one or more other embodiments disclosed herein.

[0116] When introducing elements of the present invention or its embodiments, the articles “a,” “an,” “the,” and “said” are intended to mean that there is one or more elements. The terms “comprising,” “including,” and “having” are intended to be comprehensive and mean that there may be additional elements other than those listed.

[0117] Modifications and alterations of the disclosed embodiments are possible without departing from the scope of the invention as defined in the attached claims. For example, where certain dimensions are given, it should be understood that they are illustrative only and other dimensions are possible. Since various modifications can be made to the above structures, products, and methods without departing from the scope of the invention, all matters included in the above description and shown in the attached drawings are intended to be interpreted as illustrative rather than restrictive.

Claims

1. A port connector for connecting a device to be sterilized to a sterilization device, wherein the fluid port has a distal end defining a fluid port outlet, the fluid port defines a lumen extending proximal to the fluid port outlet, and the port connector is A housing configured to be coupled to the fluid port, comprising: an inlet configured to be fluidly coupled to the lumen of the fluid port; an outlet configured to be fluidly coupled to the sterilizer; and a fluid passage extending between the inlet and the outlet and fluidly coupling the inlet and the outlet; A porous member supported by the housing, having a porous structure defining a plurality of micro-passages, and positioned relative to the housing so as to engage with the distal end of the fluid port when the port connector is connected to the fluid port, A port connector equipped with the following features.

2. The port connector according to claim 1, wherein the porous member is positioned relative to the housing such that, when the port connector is connected to the fluid port, at least a portion of the micro-passages fluidly couples the fluid port outlet to the external environment of the port connector.

3. The port connector according to claim 1 or 2, wherein the porous member is arranged relative to the housing such that the porous member covers a portion of the fluid port outlet.

4. The port connector according to any one of claims 1 to 3, wherein the porous member includes an annular surface disposed to engage with the distal end of the fluid port.

5. The port connector according to claim 4, wherein the annular surface has an inner diameter smaller than the diameter of the fluid port outlet.

6. The port connector according to claim 5, wherein the annular surface has an outer diameter larger than the diameter of the fluid port outlet.

7. The port connector according to any one of claims 1 to 6, wherein the housing includes an insertion portion formed to be dimensioned to be inserted into the fluid port outlet, the insertion portion defining the inlet.

8. The port connector according to claim 7, wherein the porous member is supported by the insertion portion.

9. The port connector according to any one of claims 1 to 8, wherein the housing includes a coupler configured to connect the port connector to the fluid port.

10. The port connector according to claim 9, wherein the coupler comprises a first elastically flexible clip and a second elastically flexible clip, the first and second clips being configured to engage with the fluid port to connect the port connector to the fluid port.

11. The port connector according to claim 10, wherein the first and second clips each include a retainer configured to engage with the fluid port to secure the port connector to the fluid port.

12. In a method for sterilizing a device having a fluid port, A step of connecting a port connector to the fluid port, wherein the port connector defines an inlet that fluidly communicates with the fluid port, an outlet, and a fluid passage that extends between the inlet and the outlet and fluidly connects the inlet and the outlet, and the port connector has a porous member that engages with the end of the fluid port, The steps include: connecting the sterilization device to the outlet of the port connector; The steps include: sterilizing the end of the fluid port by moving a sterilizing fluid through the porous member while the port connector is connected to the fluid port; A method that includes this.

13. The method according to claim 12, further comprising the step of sterilizing the device with the sterilizing fluid while the port connector is connected to the fluid port.

14. The method according to claim 12 or 13, wherein the step of sterilizing the device includes the step of moving the sterilizing fluid through the lumen of the device, through the fluid port, and through the port connector.

15. The method according to claim 14, wherein the step of moving the sterilization fluid through the lumen, the fluid port, and the port connector includes the step of drawing the sterilization fluid through the lumen, the fluid port, and the port connector by applying a pressure difference from a pressure source.

16. The method according to any one of claims 12 to 15, wherein the step of sterilizing the end of the fluid port and the step of sterilizing the device are performed substantially simultaneously.

17. The method according to any one of claims 12 to 16, further comprising the steps of placing the device in a cleaning chamber and supplying the sterilization fluid to the cleaning chamber before moving the sterilization fluid.

18. In a port connector for connecting to a fluid port of a device to be sterilized to a sterilization device, the fluid port defines a lumen, and the port connector is A porous member having a porous structure defining a plurality of micro-passages, wherein the porous member defines at least a portion of a receiving chamber formed to receive the fluid port, and the porous member is positioned so that its inner surface engages with the fluid port when the fluid port is placed within the receiving chamber, A housing coupled to the porous member, comprising: an inlet configured to be fluidly coupled to the lumen of the fluid port; an outlet configured to be fluidly coupled to the sterilizer; and a fluid passage extending between the inlet and the outlet and fluidly coupling the inlet and the outlet, wherein the inlet is located in at least a portion of the receiving chamber defined by the inner surface of the porous member; A port connector equipped with the following features.

19. The port connector according to claim 18, wherein at least a portion of the micro-passages of the porous member fluidly couples the receiving chamber to the external environment of the port connector.

20. The port connector according to claim 18 or 19, wherein the porous member is configured to form an interlocking fit with the fluid port.

21. The port connector according to any one of claims 18 to 20, further comprising a porous control material for coating one or more surfaces of the porous member in order to define a flow path through the porous member.

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