Catheter stabilization devices, systems, and methods

Abstract

A device configured for use at a catheter insertion site in a subject may include a base configured to be secured to the subject's skin across the insertion site and a catheter hub holder configured to secure to a catheter hub connected to a catheter configured for insertion at the insertion site. The catheter hub holder may be movably coupled to the base to allow relative movement between the base and the catheter hub and catheter. The catheter hub holder and base may be connected via a gimbal configuration. The base may include a membrane configured to secure to the subject's skin and a frame. In some implementations, the catheter hub holder is rotatably coupled to a clamp connected to the frame. In some implementations, the clamp is pivotally connected to the frame and configured to pivot between an open position and a closed position.

Description

[Technical Field]

[0001] Incorporation by reference of priority applications This application claims the benefit of U.S. Provisional Patent Application No. 63 / 600,566, filed November 17, 2023, and U.S. Provisional Patent Application No. 63 / 387,670, filed December 15, 2022. Each of the above applications is hereby incorporated by reference in its entirety.

[0002] Generally, the present disclosure relates to catheter stabilization devices, systems, and methods. [Background technology]

[0003] Intravenous catheterization has been available to patients for over a century. Peripherally inserted central venous catheters (PIVCs) and peripherally inserted central catheters (PICCs) are commonly used by patients in hospitals or other care facilities to provide medications, nutrients, or fluids. After irrigating the catheter insertion site, a needle is inserted into the patient's vein, and then the catheter is inserted into the vein. Such catheters are typically connected to a catheter hub. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] International Publication No. 2022 / 140633 Brochure Summary of the Invention [Problem to be solved by the invention]

[0005] Stabilizing a catheter at the catheter insertion site is important, among other things, to prevent catheter migration and to ensure that the purpose for which the catheter is used (e.g., intravenous therapy) is achieved. Conventional techniques for stabilizing a catheter involve applying one or more adhesive film dressings directly over the catheter hub connected to the catheter and the catheter insertion site. Such techniques have various drawbacks. For example, they do not adequately prevent the catheter from migrating (e.g., due to patient movement) and from being pushed further into the patient's arm (or other body part). Adhesive dressings used in such techniques can harbor and cultivate germs and bacteria at the insertion site, which can lead to various infections and complications. Frequent replacement of such adhesive dressings or catheters can increase the risk of bacterial infection and cause inflammation and trauma at the catheter insertion site (e.g., in elderly patients). Other drawbacks of conventional techniques include inhibiting normal skin respiration and airflow, increasing humidity and temperature at the insertion site (which can promote microbial growth), causing the catheter tip to be at an improper angle within the blood vessel, obscuring visualization of the catheter insertion site (thereby inhibiting assessment of the current state of the catheter and insertion site), and often causing the catheter to "kink." [Means for solving the problem]

[0006] Disclosed herein are various implementations of devices, systems, and methods for stabilizing a catheter at a catheter insertion site that address, among other things, one or more of the aforementioned shortcomings. The various implementations of the devices disclosed herein are configured to stabilize the catheter at the catheter insertion site and prevent relative movement between the catheter and the blood vessel into which the catheter extends and / or the catheter insertion site. This further improves the integrity and condition of the catheter insertion site and the blood vessel into which the catheter is inserted. For example, various implementations of the devices disclosed herein include a first portion configured to be secured to the subject's skin and a second portion movably coupled to the first portion and configured to be secured to a catheter hub connected to the catheter. Allowing relative movement of the device between such first and second positions allows for relative movement between the first portion (secured to the subject's skin), the catheter hub, and the connected catheter. The blood vessel into which the catheter is inserted may not move proportionally to the skin to which such first portion is secured. Thus, allowing relative movement between the first portion of the device and the catheter hub and connected catheter can prevent relative movement between the catheter and the blood vessel. Such a configuration can prevent the catheter hub and connected catheter from being dislodged and coming into contact with the blood vessel wall if the first portion of the device is moved (e.g., by inadvertent force).

[0007] Disclosed herein is a catheter stabilization device configured for use at a catheter insertion site on a subject's skin, the catheter stabilization device comprising: a first portion configured to be secured to one or more portions of the subject's skin; and a second portion configured to be secured to a catheter hub coupled to a catheter configured for insertion at the catheter insertion site, the first portion and the second portion of the catheter stabilization device being movably coupled to one another to allow relative movement between the first portion of the catheter stabilization device and the catheter hub when the catheter stabilization device is in use and the catheter is inserted at the catheter insertion site.

[0008] In some implementations, the first portion is configured to surround a catheter insertion site when secured to the one or more portions of the subject's skin. In some implementations, the second portion does not contact the subject's skin when secured to the one or more portions of the subject's skin. In some implementations, at least a portion of the first portion of the catheter stabilization device configured to contact the one or more portions of the subject's skin is made from a first material, and the second portion of the catheter stabilization device is made from a second material that is stiffer than the first material. In some implementations, the second portion is configured to move relative to the first portion along a first axis and along a second axis that is perpendicular to the first axis. In some implementations, the second portion is configured to rotate about at least one of the first axis and the second axis. In some implementations, the second portion is configured to rotate about the at least one of the first axis and the second axis by an amount that is between about 5 degrees and about 45 degrees. In some implementations, the second portion is configured to rotate about at least one of the first axis and the second axis by an amount that is between about 5 degrees and about 30 degrees. In some implementations, the second portion is configured to rotate about each of the first axis and the second axis. In some implementations, the second portion is further configured to move relative to the first portion along a third axis that is perpendicular to both the first axis and the second axis. In some implementations, the second portion is configured to rotate about each of at least two of the first axis, the second axis, and the third axis. In some implementations, the second portion is configured to rotate about each of at least two of the first axis, the second axis, and the third axis by an amount that is between about 5 degrees and about 45 degrees. In some implementations, the second portion is configured to rotate about each of at least two of the first axis, the second axis, and the third axis by an amount that is between about 5 degrees and about 30 degrees.

[0009] In some implementations, the second portion is configured to move relative to the first portion along a first axis and along a second axis that is perpendicular to the first axis, and movement of the second portion relative to the first portion is prevented along a third axis that is perpendicular to both the first axis and the second axis. In some implementations, the second portion is configured to move relative to the first portion along a first axis that is perpendicular to both the second axis and the third axis, and movement of the second portion relative to the first portion along the second axis and the third axis is prevented. In some implementations, the second portion of the catheter stabilization device is configured to secure to the catheter hub such that relative movement between the second portion and the catheter hub is prevented.

[0010] In some implementations, the first portion comprises at least one receiving portion having an interior, and the second portion comprises a body and at least one arm extending outward from the body, the body configured to secure to the catheter hub, at least a portion of the at least one arm configured to be positioned within the interior of the at least one receiving portion, and the first and second portions of the catheter stabilization device are movably coupled to each other via the at least one arm and the at least one receiving portion. In some implementations, the interior of the at least one receiving portion comprises a width and a height, and the at least one arm comprises a width and a height. In some implementations, the width of the at least one arm is smaller than the width of the interior of the at least one receiving portion and / or the height of the at least one arm is smaller than the height of the interior of the at least one receiving portion. In some implementations, the width of the at least one arm is smaller than the width of the interior of the at least one receiving portion and the height of the at least one arm is smaller than the height of the interior of the at least one receiving portion.

[0011] In some implementations, the first portion comprises a frame and a membrane coupled to the frame, the membrane configured to be secured to the one or more portions of the subject's skin, and the frame comprising the at least one receiver. In some implementations, the membrane comprises an opening, the membrane configured to be secured to the subject's skin such that a catheter insertion site is positioned within the opening, and the frame coupled to the membrane along at least a portion of the periphery of the opening. In some implementations, the at least one receiver comprises a first receiver and a second receiver, the first receiver and the second receiver extending from a portion of the frame toward each other. In some implementations, the first receiver and the second receiver are substantially aligned with each other. In some implementations, the interiors of the first receiver and the second receiver have the same size and / or shape. In some implementations, the frame is spaced inward from the outer periphery of the membrane. In some implementations, the frame comprises a material that is more rigid than the membrane.

[0012] In some implementations, the body comprises a C-shape. In some implementations, the body is configured to surround at least about 50% of the cross-section of the catheter hub when the catheter stabilization device is in use. In some implementations, the body is shaped to fit around a portion of the cylindrical portion of the catheter hub. In some implementations, the body is shaped to surround less than the entire circumference of the circular cross-section of the catheter hub.

[0013] In some implementations, the at least one arm includes two arms and the at least one receiver includes two receivers. In some implementations, the two arms extend outward in opposite directions from the body. In some implementations, the two receivers are substantially aligned with one another along a first axis, and the two arms are configured to move within the two receivers. In some implementations, the two arms are configured to move within the two receivers along the first axis, along a second axis that is substantially perpendicular to the first axis, and / or along a third axis that is substantially parallel to the first axis. In some implementations, a first axis extends through a center of a cross section of the at least one arm, and the at least one arm is configured to rotate within the interior of the at least one receiver about the first axis. In some implementations, the at least one arm is configured to rotate within the interior of the at least one receiver between about 5 degrees and about 45 degrees relative to the first axis.

[0014] In some implementations, the first portion comprises at least one arm, and the second portion comprises a body and at least one receiving portion connected to the body and having an interior, the body configured to secure to the catheter hub, the interior of the at least one receiving portion configured to receive at least a portion of the at least one arm, and the first and second portions of the catheter stabilization device are movably coupled to each other via the at least one arm and the at least one receiving portion. In some implementations, the interior of the at least one receiving portion comprises a width and a height, and the at least one arm comprises a width and a height. In some implementations, the width of the at least one arm is smaller than the width of the interior of the at least one receiving portion and / or the height of the at least one arm is smaller than the height of the interior of the at least one receiving portion. In some implementations, the width of the at least one arm is smaller than the width of the interior of the at least one receiving portion and the height of the at least one arm is smaller than the height of the interior of the at least one receiving portion. In some implementations, the first portion comprises a frame and a membrane coupled to the frame, the membrane configured to be secured to the one or more portions of the subject's skin, and the frame comprising the at least one arm. In some implementations, the membrane comprises an opening, the membrane configured to be secured to the subject's skin such that a catheter insertion site is positioned within the opening, and the frame is coupled to the membrane along at least a portion of the periphery of the opening. In some implementations, the at least one arm comprises a first arm and a second arm, the first arm and the second arm extending from a portion of the frame toward each other and / or partially across the opening. In some implementations, the first arm and the second arm are substantially aligned with each other. In some implementations, the first arm and the second arm have the same size and / or shape.

[0015] In some implementations, the frame is spaced inward from the outer periphery of the membrane. In some implementations, the frame comprises a material that is more rigid than the membrane. In some implementations, the body comprises a C-shape. In some implementations, the body is configured to surround at least about 50% of the cross-section of the catheter hub when the catheter stabilization device is in use. In some implementations, the body is shaped to secure around a portion of the cylindrical portion of the catheter hub. In some implementations, the body is shaped to surround less than the entire periphery of the circular cross-section of the catheter hub.

[0016] In some implementations, the at least one arm includes two arms and the at least one receiver includes two receivers. In some implementations, the two receivers extend outward in opposite directions from the body. In some implementations, the two arms are aligned with one another substantially along a first axis, and the two receivers are configured to move relative to the two arms along the first axis, along a second axis that is substantially perpendicular to the first axis, and / or along a second axis that is substantially parallel to the first axis. In some implementations, the first axis extends through a center of a cross section of the at least one receiver, and the at least one arm is configured to rotate about the first axis when the at least one arm is positioned within the interior of the at least one receiver. In some implementations, the at least one receiver is configured to rotate between about 5 degrees and about 45 degrees relative to the first axis when the at least one arm is positioned within the interior of the at least one receiver.

[0017] In some implementations, the catheter stabilization device further comprises a third portion configured to surround the catheter insertion site. Such a third portion may comprise any of the covers disclosed herein. In some implementations, the third portion comprises any of the covers disclosed herein and any of the extension sets disclosed herein. In some implementations, the third portion is configured to removably connect to the first portion and / or the second portion.

[0018] Disclosed herein is a cover configured to at least partially surround a catheter insertion site in a subject, the cover comprising an opening configured to provide visualization of the catheter insertion site when the cover is in use, the cover further comprising a magnifying lens positioned within the opening. The opening may be positioned over (e.g., aligned with) the catheter insertion site when the cover is secured to the subject. Such a cover may be secured to the subject via a strap (e.g., wrapped around a portion of the subject's body) or an adhesive attachment. Such a cover may include any of the features described herein with respect to any of the covers disclosed herein. A catheter stabilization device may include, together with such a cover, any of the hubs disclosed herein and / or any of the extension sets disclosed herein. A catheter stabilization device may include, together with such a cover, a hub configured to at least partially secure a catheter hub connected to a catheter when the catheter is inserted at the catheter insertion site.

[0019] Disclosed herein is a catheter stabilization device comprising a first portion configured to be secured to one or more portions of a subject's skin, a second portion configured to be secured to a catheter hub coupled to a catheter configured for insertion at the catheter insertion site, and a third portion removably connectable to at least one of the first and second portions, the third portion comprising any of the covers described previously or elsewhere herein. The first and second portions of the catheter stabilization device may be movably coupled to one another to allow relative movement between the first portion of the catheter stabilization device and the catheter hub when the catheter stabilization device is in use and the catheter is inserted at the catheter insertion site.

[0020] Disclosed herein is a device configured to be secured to one or more portions of a subject's skin and configured to secure a medical component to the subject's skin to allow relative movement between the medical component and the device. In some implementations, the device comprises a first portion configured to be secured to the one or more portions of the subject's skin and a second portion configured to be secured to the medical component, the first and second portions of the device being movably coupled to one another to allow relative movement between the first portion of the device and the medical component when the device is in use. In some implementations, the medical component comprises a tube, wire, or cable. In some implementations, the device is a catheter stabilization device, the second portion configured to be secured to a catheter hub coupled to a catheter configured for insertion at a catheter insertion site, the first and second portions of the catheter stabilization device being movably coupled to one another to allow relative movement between the first portion of the catheter stabilization device and the catheter hub.

[0021] Disclosed herein is an electronic device configured to connect (e.g., removably connect) to a catheter stabilization device configured for use at a catheter insertion site in a subject, the electronic device comprising at least one of: a camera configured to generate a visual signal based on the catheter insertion site and / or a portion of the subject's skin proximate the catheter insertion site; one or more LEDs configured to illuminate the catheter insertion site and / or a portion of the subject's skin proximate the catheter insertion site; and a sensor for measuring one or more physiological parameters of the subject.

[0022] In some implementations, the electronic device further comprises a battery. In some implementations, the one or more LEDs comprise one or more broad-spectrum LEDs configured to emit light having wavelengths between a first range, one or more narrow-spectrum LEDs configured to emit light having wavelengths between a second range smaller than the first range, and one or more ultraviolet LEDs. In some implementations, the first range is between about 380 nm and about 740 nm. In some implementations, the one or more ultraviolet LEDs include at least one of one or more ultraviolet-A LEDs, one or more ultraviolet-B LEDs, and one or more ultraviolet-C LEDs. In some implementations, the one or more ultraviolet-A LEDs are configured to emit light at wavelengths between about 320 nm and about 400 nm, the one or more ultraviolet-B LEDs are configured to emit light at wavelengths between about 290 nm and about 320 nm, and / or the one or more ultraviolet-C LEDs are configured to emit light at wavelengths between about 200 nm and about 280 nm. In some implementations, the electronic device further comprises a communications module configured to transmit the generated visual signal to an external device. In some implementations, the communications module is configured to wirelessly transmit the generated visual signal to the external device. In some implementations, the electronic device further comprises a connector port configured to connect to an external device to facilitate the transmission of the generated visual signal from the communications module to the external device. In some implementations, the electronic device further comprises one or more processing units configured to receive the generated visual signal from the camera and configured to determine a condition of the catheter insertion site and / or a condition of a portion of the subject's skin proximate to the catheter insertion site based on the received visual signal.In some implementations, the one or more processing devices are configured to receive one or more visual signals generated by the camera during a first time period, receive one or more visual signals generated by the camera during a second time period that is after the first time period, compare the one or more visual signals generated by the camera during the first time period with the one or more visual signals generated by the camera during the second time period, and determine the condition of the catheter insertion site and / or the condition of a portion of the subject's skin proximate to the catheter insertion site based at least on the comparison.

[0023] Disclosed herein is a system including an electronic device according to any of the previously described implementations and further comprising an external device, wherein the electronic device is configured to transmit the generated visual signals to the external device, the external device being configured to receive one or more visual signals generated by the camera during a first time period and one or more visual signals generated by the camera during a second time period that is after the first time period, and comprising one or more processing units configured to compare the one or more visual signals generated by the camera during the first time period with the one or more visual signals generated by the camera during the second time period, and to determine a condition of the catheter insertion site and / or a condition of a portion of the subject's skin proximate to the catheter insertion site based at least on the comparison.

[0024] Disclosed herein is a system including an electronic device according to any of the previously described implementations, further comprising a catheter stabilization device, such as any of the catheter stabilization devices disclosed herein. In some implementations, the electronic device comprises one or more pins, the catheter stabilization device comprises one or more cavities configured to receive the one or more pins, and the electronic device is configured to removably connect to the catheter stabilization device via engagement between the one or more pins and the one or more cavities. In some implementations, the catheter stabilization device comprises one or more pins, the electronic device comprises one or more cavities configured to receive the one or more pins, and the electronic device is configured to removably connect to the catheter stabilization device via engagement between the one or more pins and the one or more cavities. In some implementations, the catheter stabilization device comprises a cover, the cover being any of the covers disclosed herein. In some implementations, the cover comprises a transparent material, and when the electronic device is connected to the cover, the cover is positioned between a catheter insertion site and a camera. In some implementations, the cover includes an opening configured to provide viewing of the catheter insertion site when the cover is in use, and the electronic device is spaced from the opening when connected to the cover. In some implementations, the cover further includes a magnifying lens positioned within the opening.

[0025] Disclosed herein is a device configured for use at a catheter insertion site on a subject's skin, the device comprising: a first portion configured to be secured to the subject's skin; and a second portion configured to be secured to a catheter hub coupled to a catheter configured for insertion at the catheter insertion site, the first and second portions being movably coupled to one another to allow relative movement between the first portion and the catheter hub when the catheter is inserted at the catheter insertion site.

[0026] In some implementations, the first and second portions of the device are coupled to one another via a gimbal configuration. In some implementations, the second portion is rotatable relative to the first portion. In some implementations, the second portion is configured to rotate at least partially relative to the first portion about at least one of three axes, the three axes being perpendicular to one another. In some implementations, the second portion is configured to rotate at least partially relative to the first portion about at least two of the three axes. In some implementations, the second portion is configured to rotate at least partially relative to the first portion about each of the three axes.

[0027] In some implementations, the second portion comprises a ball, and the first portion comprises a cavity configured to receive the ball, the ball being rotatable within the cavity. In some implementations, the cavity is configured to prevent the ball from being removed from the cavity. In some implementations, the ball is at least partially rotatable within the cavity about each of three axes, the three axes being perpendicular to one another. In some implementations, the first and second portions are configured such that the ball is only partially rotatable within the cavity about each of the three axes. In some implementations, when a catheter hub is secured to the second portion of the device and the first portion of the device is secured to the subject's skin, the catheter hub is positioned closer to the subject's skin than the ball and / or the cavity.

[0028] In some implementations, the first portion comprises a frame, a membrane coupled to the frame and configured to be secured to the subject's skin, and a clamp coupled to the frame, the clamp comprising the cavity. In some implementations, the clamp is pivotally connected to the frame. In some implementations, the membrane comprises an opening, the membrane configured to be secured to the subject's skin such that a catheter insertion site is positioned within the opening, and the frame is coupled to the membrane along at least a portion of a periphery of the opening. In some implementations, the clamp extends across the opening in the membrane. In some implementations, the clamp extends from a first side of the frame to a second side of the frame opposite the first side of the frame. In some implementations, the clamp comprises a first end configured to be connected to the first side of the frame and a second end configured to be connected to the second side of the frame. In some implementations, the cavity is disposed between the first end and the second end of the clamp. In some implementations, the first end is pivotally connected to the first side of the frame and configured to pivot between a first position in which the second end is secured to the second side of the frame and a second position in which the second end is not secured to the second side of the frame. In some implementations, the clamp comprises a pin at the first end, and the frame is configured to pivotally secure the pin. In some implementations, the clamp comprises one or more biological hinges configured to pivot the clamp between the first and second positions. In some implementations, the one or more biological hinges are disposed at the first end of the clamp. In some implementations, the one or more biological hinges comprise a first biological hinge and a second biological hinge spaced from the first biological hinge. In some implementations, the clamp further comprises one or more posts, and the frame comprises one or more openings configured to receive the one or more posts. In some implementations, the one or more posts are disposed at the first end of the clamp and configured to secure the first end of the clamp to the frame.

[0029] In some implementations, the second portion includes at least one protrusion extending outward from the ball, and the clamp further includes at least one slot configured to receive the at least one protrusion. In some implementations, the at least one slot is configured to limit rotation of the ball through contact with the at least one protrusion. In some implementations, the at least one slot is configured to limit an angle of rotation of the ball about a first axis extending through a center of the cavity. In some implementations, the first portion is configured to limit an angle of rotation of the ball about a second axis perpendicular to the first axis. In some implementations, the second portion is a catheter hub retainer including a body configured to secure to the catheter hub, a shaft having a first end connected to the body and a second end opposite the first end of the shaft, and the ball, wherein the ball is connected to the second end of the shaft. In some implementations, the body comprises two curved legs having cantilevered ends spaced apart from one another, and the second portion further comprises a pair of arms extending from each of the cantilevered ends away from one another, the pair of arms configured to facilitate securement of the catheter hub within the body. In some implementations, the device further comprises a cover configured to removably secure to the first portion and at least partially enclose a catheter insertion site.

[0030] In some implementations, the device further includes a fluid conduit assembly configured to deliver one or more fluids to the catheter. In some implementations, the fluid conduit assembly includes a first connector configured to connect to the catheter hub, a first tube having a first end connected to the first connector and a second end opposite the first end, a second connector connected to the second end of the first tube, and a second tube having a first end connected to the second connector and a second end opposite the first end of the second tube. In some implementations, the second connector is configured to fluidly couple the first and second tubes together and is further configured to engage a portion of the cover, wherein when the second connector is engaged with the portion of the cover, the first tube is disposed within an interior of the cover and the second tube is disposed outside the interior, and the first tube comprises a flexible material configured to accommodate the relative movement between the first portion and the catheter hub when the first connector is connected to the catheter. In some implementations, the first tube is more flexible than the second tube, the second tube is more rigid than the first tube, and / or the second tube is more durable than the first tube.

[0031] Disclosed herein is an assembly for delivering fluid to a subject via a catheter inserted at a catheter insertion site, the assembly comprising: a cover configured to be positioned over the catheter insertion site; and a fluid delivery assembly configured to be connected to the cover. In some implementations, the fluid delivery assembly comprises a first tube configured to be connected to a catheter hub connected to the catheter, and a second tube connected to the first tube. In some implementations, the fluid delivery assembly is configured such that when the fluid delivery assembly is connected to the cover, the first tube extends within an interior of the cover and the second tube extends outside the interior, and the first tube comprises a flexible material configured to accommodate movement of the catheter hub when the first tube is connected to the catheter.

[0032] In some implementations, the fluid delivery assembly further includes a first connector configured to connect the first and second tubes to one another, the first connector configured to engage a portion of the cover. In some implementations, when the first connector is engaged with the portion of the cover, the first tube extends within the interior of the cover and the second tube extends outside the interior. In some implementations, the fluid delivery assembly further includes a second connector configured to connect the first tube to the catheter hub. In some implementations, the fluid delivery assembly further includes a third connector configured to secure the second connector to the portion of the cover. In some implementations, the third connector secures (e.g., threads) to the portion of the cover and / or to a portion of the second connector. In some implementations, a portion of the second connector is received by a portion of the third connector. In some implementations, the first tube is more flexible than the second tube, the second tube is more rigid than the first tube, and / or the second tube is more durable than the first tube. In some implementations, the assembly further comprises a hub configured to be secured to the subject's skin and to the catheter hub, such a hub may comprise any of the hubs disclosed herein.

[0033] Disclosed herein is a device configured for use at a catheter insertion site of a subject, the device comprising: a base having an opening configured to be secured to the skin of the subject so that the opening is positioned over the catheter insertion site; and a catheter hub holder configured to secure to a catheter hub connected to a catheter configured for insertion at the catheter insertion site, the catheter hub holder being movably coupled to the base to allow relative movement between the base and the catheter hub when the catheter is inserted at the catheter insertion site.

[0034] In some implementations, the catheter hub holder is movably coupled to the base via a gimbal arrangement. In some implementations, the catheter hub holder is rotatably coupled to the base and configured to rotate at least partially about three mutually orthogonal axes. In some implementations, the catheter hub holder comprises a ball, and the base comprises a cavity configured to receive the ball, the ball being rotatable within the cavity. In some implementations, the catheter hub holder further comprises: a body surrounding a portion of the catheter hub and configured to be secured to the portion of the catheter hub; and a shaft connected to the body and the ball and extending between the body and the ball such that the ball is spaced from the body. In some implementations, the body is configured to hold the catheter hub above the subject's skin when the device is in use. In some implementations, the base further comprises a membrane configured to be secured to the subject's skin and a frame connected to the membrane, the frame being more rigid than the membrane, and the catheter hub holder movably coupled to the frame. In some implementations, the base further comprises a clamp connected to the frame, the clamp comprising the cavity in the base, and the catheter hub retainer being movably coupled to the frame via the clamp. In some implementations, at least one of the catheter hub retainer and the clamp is configured such that rotation of the catheter hub retainer relative to the clamp is limited about at least one of the three mutually orthogonal axes. In some implementations, the clamp comprises at least one slot, and the catheter hub retainer further comprises at least one ear extending outward from the ball and positioned in the at least one slot in the clamp, wherein contact between a portion of the clamp forming the at least one slot and the at least one ear limits the amount of rotation of the catheter hub retainer relative to the clamp about at least one of the three mutually orthogonal axes.In some implementations, the membrane comprises the opening in the base, the frame is connected to the membrane along the periphery of the opening, and the clamp comprises a first end and a second end, the first end pivotally connected to a first portion of the frame such that the clamp is pivotable between a closed position and an open position, wherein in the closed position, the second end of the clamp is connected to the second portion of the frame and in the open position, the second end of the clamp is not connected to the second portion of the frame. In some implementations, the clamp comprises a pin at the first end, and the first portion of the frame is configured to pivotally secure the pin. In some implementations, the clamp comprises one or more biological hinges at the first end configured to pivot the clamp between the open position and the closed position. In some implementations, the clamp further comprises a latch at the second end configured to removably connect to one or more protrusions disposed on the second portion of the frame. In some implementations, the device further comprises a cover configured to removably connect to the base and to surround the opening and the catheter insertion site.

[0035] Certain features of the present disclosure are described below with reference to the drawings. The illustrated embodiments are intended to illustrate the embodiments and not to limit the embodiments. Various features of different disclosed embodiments can be combined to form further embodiments that are part of this disclosure. [Brief explanation of the drawings]

[0036] [Figure 1A] FIG. 1 is a perspective view of a catheter stabilization device according to aspects of the present disclosure. [Figure 1B] FIG. 1 is a perspective view of a catheter stabilization device according to aspects of the present disclosure. [Figure 1C] FIG. 1C is a bottom perspective view of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1D] FIG. 1C is a top view of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1E]FIG. 1C is a bottom view of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1F] FIG. 1C is a cross-sectional view taken through a portion of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1G] FIG. 1C is an exploded view of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1H] FIG. 1C is a view of a cover of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1I] FIG. 1C is a view of a cover of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1J] FIG. 1C is a view of a cover of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1K] FIG. 1C is a view of a cover of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1L] FIG. 1C is an exploded view of an extension set of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1M] FIG. 1C is a perspective view of a hub of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1N] FIG. 1C is a perspective view of a hub of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1O] FIG. 1C is a perspective view of a hub of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1P] FIG. 1C is a perspective view of a hub of the catheter stabilization device of FIGS. 1A-1B according to an embodiment of the present disclosure. [Figure 1Q] FIG. 1B is a bottom view of the hub of FIGS. 1M-1P according to an embodiment of the present disclosure. [Figure 1Q] FIG. 1B is a top view of the hub of FIGS. 1M-1P according to an embodiment of the present disclosure. [Figure 1S] FIG. 1C is a cross-sectional view taken through a portion of the hub of FIGS. 1M-1P according to an embodiment of the present disclosure. [Figure 1T]FIG. 1C is a cross-sectional view taken through a portion of the hub of FIGS. 1M-1P according to an embodiment of the present disclosure. [Figure 1U] FIG. 1C is a cross-sectional view taken through a portion of the hub of FIGS. 1M-1P according to an embodiment of the present disclosure. [Figure 1V] 1A-1C are diagrams of an implementation of a catheter hub retainer according to aspects of the present disclosure. [Figure 1W] 1A-1C are diagrams of an implementation of a catheter hub retainer according to aspects of the present disclosure. [Figure 1X] 1A-1C are diagrams of an implementation of a catheter hub retainer according to aspects of the present disclosure. [Figure 1Y] 1A-1C are diagrams of an implementation of a catheter hub retainer according to aspects of the present disclosure. [Figure 1Z] FIG. 1B is an enlarged view of a portion of the hub of FIGS. 1M-1P according to an embodiment of the present disclosure. [Figure 1AA] 10 is a cross-sectional view of a portion of another implementation of a hub according to aspects of the present disclosure. [Figure 1BB] 10 is a cross-sectional view of a portion of another implementation of a hub according to aspects of the present disclosure. [Figure 2A] FIG. 1 is a diagram of an electronic device according to an aspect of the present disclosure. [Figure 2B] FIG. 1 is a diagram of an electronic device according to an aspect of the present disclosure. [Figure 2C] FIG. 1 is a diagram of an electronic device according to an aspect of the present disclosure. [Figure 2D] FIG. 1 is a diagram of an electronic device according to an aspect of the present disclosure. [Figure 3A] 2A-2D are diagrams of embodiments of a cover that can be connected to the electronic device of FIGS. 2A-2D. [Figure 3B] 2A-2D are diagrams of embodiments of a cover that can be connected to the electronic device of FIGS. 2A-2D. [Figure 3C] 1 is a diagram of such a cover connected to an electronic device. [Figure 3D] 1 is a diagram of such a cover connected to an electronic device. [Figure 4A] FIG. 10 is a top perspective view of another implementation of a catheter stabilization device according to aspects of the present disclosure. [Figure 4B]FIG. 10 is a top perspective view of another implementation of a catheter stabilization device according to aspects of the present disclosure. [Figure 4C] FIG. 10 is a bottom perspective view of another implementation of a catheter stabilization device according to aspects of the present disclosure. [Figure 4D] FIG. 4C is a top view of the catheter stabilization device of FIGS. 4A-4B according to an embodiment of the present disclosure. [Figure 4E] FIG. 4C is a bottom view of the catheter stabilization device of FIGS. 4A-4B according to an embodiment of the present disclosure. [Figure 4F] FIG. 5 is a cross-sectional view taken through a portion of the catheter stabilization device of FIGS. 4A-4D according to an embodiment of the present disclosure. [Figure 4G] FIG. 4D is an exploded view of the catheter stabilization device of FIGS. 4A-4D according to an embodiment of the present disclosure. [Figure 4H] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4I] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4J] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4K] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4L] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4M] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4N] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4O] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4P] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4Q]4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4R] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4S] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4T] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4U] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4V] 4A-4D according to an embodiment of the present disclosure. FIG. [Figure 4W] FIG. 5 is a top perspective view of a hub of the catheter stabilization device of FIGS. 4A-4D according to an embodiment of the present disclosure. [Figure 4X] FIG. 5 is a top perspective view of a hub of the catheter stabilization device of FIGS. 4A-4D according to an embodiment of the present disclosure. [Figure 4Y] FIG. 5 is a top perspective view of a hub of the catheter stabilization device of FIGS. 4A-4D according to an embodiment of the present disclosure. [Figure 4Z] FIG. 5 is a top perspective view of a hub of the catheter stabilization device of FIGS. 4A-4D according to an embodiment of the present disclosure. [Figure 4AA] 4W-4Z according to an embodiment of the present disclosure. FIG. [Figure 4BB] FIG. 4B is a bottom view of the hub of FIGS. 4W-4Z according to an embodiment of the present disclosure. [Figure 4CC] 4W-4Z according to an embodiment of the present disclosure. FIG. [Figure 4DD] 4W-4Z according to an embodiment of the present disclosure. FIG. [Figure 4EE] FIG. 4B is a front view of the hub of FIGS. 4W-4Z according to an embodiment of the present disclosure. [Figure 4FF] FIG. 4B is a rear view of the hub of FIGS. 4W-4Z according to an embodiment of the present disclosure. [Figure 4GG] FIG. 4W is a cross-sectional view taken through a portion of the hub of FIGS. 4W-4Z according to an embodiment of the present disclosure. [Figure 4HH] 4W-4Z according to an embodiment of the present disclosure. FIG. [Figure 4II] 4W-4Z according to an embodiment of the present disclosure. FIG. [Figure 4JJ] 4W-4Z according to an embodiment of the present disclosure. FIG. [Figure 4KK] 4W-4Z according to an embodiment of the present disclosure. FIG. [Figure 4LL] 1A-1C are diagrams of an implementation of a catheter hub retainer according to aspects of the present disclosure. [Figure 4MM] 1A-1C are diagrams of an implementation of a catheter hub retainer according to aspects of the present disclosure. [Figure 4NN] 1A-1C are diagrams of an implementation of a catheter hub retainer according to aspects of the present disclosure. [Figure 4OO] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 4PP] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 4QQ] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 4RR] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 4SS] FIG. 4W is a cross-sectional view taken through a portion of the hub of FIGS. 4W-4Z according to an embodiment of the present disclosure. [Figure 4TT] FIG. 4W is a cross-sectional view taken through a portion of the hub of FIGS. 4W-4Z according to an embodiment of the present disclosure. [Figure 5A] FIG. 10 is a top perspective view of another implementation of a catheter stabilization device according to aspects of the present disclosure. [Figure 5B] FIG. 5B is a top view of the catheter stabilization device of FIG. 5A according to an embodiment of the present disclosure. [Figure 5C] FIG. 5C is a cross-sectional view taken through a portion of the catheter stabilization device of FIGS. 5A-5B according to an embodiment of the present disclosure. [Figure 5D]FIG. 5D is an enlarged view of a portion of what is shown in FIG. 5C. [Figure 5E] FIG. 5B is a top perspective view of a cover of the catheter stabilization device of FIG. 5A according to an embodiment of the present disclosure. [Figure 5F] FIG. 5B is a top perspective view of a cover of the catheter stabilization device of FIG. 5A according to an embodiment of the present disclosure. [Figure 5G] FIG. 5B is a diagram of an extension set of the catheter stabilization device of FIG. 5A according to an embodiment of the present disclosure. [Figure 5H] FIG. 5G is a diagram of a portion of the extension set of FIG. 5G according to an embodiment of the present disclosure. [Figure 6A] FIG. 10 is a top perspective view of another implementation of a catheter stabilization device according to aspects of the present disclosure. [Figure 6B] FIG. 6B is a top view of the catheter stabilization device of FIG. 6A according to an embodiment of the present disclosure. [Figure 6C] FIG. 6C is a cross-sectional view taken through a portion of the catheter stabilization device of FIGS. 6A-6B according to an embodiment of the present disclosure. [Figure 6D] 6A-6B according to an embodiment of the present disclosure. FIG. [Figure 6E] FIG. 6C is a view of a portion of an extension set of the catheter stabilization device of FIGS. 6A-6B according to an embodiment of the present disclosure. [Figure 6F] FIG. 6C is a view of a portion of an extension set of the catheter stabilization device of FIGS. 6A-6B according to an embodiment of the present disclosure. [Figure 6G] FIG. 6D is an enlarged view of a portion of what is shown in FIG. 6C. [Figure 7A] FIG. 1 is a top perspective view of an implementation of a hub according to aspects of the present disclosure. [Figure 7B] FIG. 1 is a top perspective view of an implementation of a hub according to aspects of the present disclosure. [Figure 7C] FIG. 1 is a top perspective view of an implementation of a hub according to aspects of the present disclosure. [Figure 7D] FIG. 1 is a top perspective view of an implementation of a hub according to aspects of the present disclosure. [Figure 7E] 7A-7D according to an embodiment of the present disclosure. FIG. [Figure 7F]FIG. 7B is a bottom view of the hub of FIGS. 7A-7D according to an embodiment of the present disclosure. [Figure 7G] 7A-7D according to an embodiment of the present disclosure. FIG. [Figure 7H] FIG. 8 is a side view of the hub of FIGS. 7A-7D according to an embodiment of the present disclosure. [Figure 7I] FIG. 8 is a front view of the hub of FIGS. 7A-7D according to an embodiment of the present disclosure. [Figure 7I] FIG. 7B is a rear view of the hub of FIGS. 7A-7D according to an embodiment of the present disclosure. [Figure 7K] 7A-7D according to an embodiment of the present disclosure. [Figure 7L] 7A-7D according to an embodiment of the present disclosure. [Figure 7M] 7A-7D according to an embodiment of the present disclosure. [Figure 7N] 7A-7D according to an embodiment of the present disclosure. [Figure 7O] 7A-7D according to an embodiment of the present disclosure. [Figure 7P] 7A-7D according to an embodiment of the present disclosure. [Figure 7Q] 7A-7D according to an embodiment of the present disclosure. [Figure 7R] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 7S] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 7T] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 7U] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 8A] FIG. 10 is a top perspective view of another implementation of a hub according to aspects of the present disclosure. [Figure 8B] FIG. 10 is a top perspective view of another implementation of a hub according to aspects of the present disclosure. [Figure 8C] FIG. 8C is an exploded perspective view of a portion of the hub of FIGS. 8A-8B according to an embodiment of the present disclosure. [Figure 8D]FIG. 8C is an enlarged view of a portion of the hub of FIGS. 8A-8B according to an embodiment of the present disclosure. [Figure 8E] 1A-1C are diagrams of an implementation of a catheter hub retainer according to aspects of the present disclosure. [Figure 8F] 1A-1C are diagrams of an implementation of a catheter hub retainer according to aspects of the present disclosure. [Figure 8G] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 8H] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 8I] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. [Figure 8J] 1A-1C are diagrams of implementations of clamps according to aspects of the present disclosure. DETAILED DESCRIPTION OF THE INVENTION

[0037] Various features and advantages of the devices, systems, and methods of the technology described herein will become more fully apparent from the following description of illustrated examples. These examples are intended to illustrate the principles of the disclosure, and the disclosure should not be limited to the illustrated examples. Features of the illustrated examples can be changed, combined, removed, and / or substituted, as would be apparent to one skilled in the art based on a consideration of the principles disclosed herein.

[0038] 1A-1F illustrate a catheter stabilization device 100 (which may also be referred to as a “catheter housing,” “catheter housing device,” “catheter solid device,” “catheter stabilization system,” or “device”). FIGS. 1A-1B illustrate a top perspective view, FIG. 1C illustrates a bottom perspective view, and FIGS. 1D-1E illustrate top and bottom views (respectively) of the catheter stabilization device 100. FIG. 1G illustrates an exploded view of an implementation of the catheter stabilization device 100 adjacent a catheter 141 and a catheter hub 142 connected to the catheter 141. The catheter 141 (which may also be referred to as a “catheter cannula”) may be configured to be inserted into a blood vessel of a subject, for example, with the use of a needle that may be coupled (e.g., retractably coupled) to the catheter hub 142, as will be understood by those skilled in the art. FIG. 1F illustrates a cross-section taken through a portion of the catheter stabilization device 100 (as indicated in FIGS. 1E-1F) in use, in which the device 100 is secured to the skin of a subject. Although not shown in FIG. 1F, it is understood that the catheter 141 may be at least partially positioned within a blood vessel of a subject when in use. Referring to FIG. 1G, the catheter stabilization device 100 may include a cover 120 and a hub 160. In some implementations, the catheter stabilization device 100 includes an extension set 140. In some implementations, the cover 120 and the extension set 140 are coupled to one another, for example, in a manner similar to that described with respect to any of the covers and extension sets in commonly owned U.S. Patent Application Publication No. 2010 / 0229994, which is incorporated herein by reference in its entirety. In some variations, the catheter stabilization device 100 includes the hub 160 but does not include the cover 120 and / or does not include the extension set 140. In some variations, the catheter stabilization device 100 does not include the cover 120 but does not include the hub 160 and / or does not include the extension set 140.

[0039] 1H-1I and 1K show top perspective views of cover 120, and FIG. 1J shows a bottom perspective view of cover 120. Cover 120 may be similar or identical in some or many respects to any of the covers disclosed in U.S. Patent Application Publication No. 2006 / 0129994. Cover 120 may include an upper portion 123a and a wall 123b extending outwardly from upper portion 123a. Wall 123b may extend laterally (e.g., generally perpendicular to upper portion 123a) of such upper portion 123a and / or may define the periphery of cover 120. Cover 120 may be made from a variety of materials, including plastics such as polyphenyl ether (PPE), polycarbonate (PC), and the like, among others. In some implementations, cover 120 is transparent or translucent. In some implementations, cover 120 is made from a more rigid material than hub 160 or portions of hub 160. For example, in some implementations, cover 120 is made from a more rigid material than membrane 162 of hub 160. In some implementations, cover 120 includes one or more wings 122 that can extend outward from wall 123b and / or top portion 123a. Wings 122 can extend outward from wall 123b and / or top portion 123a and can be utilized to secure tube 147 when in use. Wings 122 can include openings 122a (which may also be referred to as slots) that can allow a portion of tube 147 to be visible and / or can receive a portion of a strap that can be used to secure cover 120 (and / or hub 160 and extension set 140, if connected to cover 120) to a subject, such as by wrapping it around the subject's arm. In some implementations, wings 122 include one or more ribs to assist a user in gripping and / or handling cover 120.

[0040] In some implementations, cover 120 includes protrusions 139a configured to engage latch arms 173a of hub 160. Additionally or alternatively, cover 120 may include protrusions 139b that may be configured to engage latch arms 173b of hub 160. The engagement between protrusions 139a, 139b and latch arms 173a, 173b may secure cover 120 and hub 160 to one another.

[0041] The cover 120 may include a connector 131 configured to facilitate connection to the extension set 140. The connector 131 may extend from the wall 123b of the cover 120 around the opening 133. The connector 131 may be secured to a connector 146 of the extension set 140. In some implementations, when the connectors 131, 146 are connected to one another, movement (e.g., sliding) of the cover 120 and / or the connector 146 relative to the tube 147 may be inhibited (e.g., prevented), and when the connectors 131, 146 are disconnected from one another, movement (e.g., sliding) of the cover 120 and / or the connector 146 relative to the tube 147 may be permitted. The connector 131 may include a connector body 131a extending outwardly from the wall 123b and a threaded portion 131b extending outwardly from the connector body 131a. Connector body 131a and / or threaded portion 131b may have a generally cylindrical shape and may have an opening that aligns with opening 133 to allow extension through tube 147.

[0042] Cover 120 may include one or both of ports 137a, 137b, which may extend from a portion of cover 120, such as wall 123b (or alternatively, from top portion 123a). Ports 137a, 137b may be similar to or identical to any of the ports disclosed in U.S. Patent Application Publication No. 2009 / 022990. Referring to FIG. 1J, cover 120 may include openings 137c, 137d to facilitate fluid communication between ports 137a, 137b and an interior of cover 120 (e.g., an interior defined by top portion 123a and wall 123b). As also shown in FIG. 1J, cover 120 may include opening 133. Opening 133 may be sized and / or shaped to correspond to the size and / or shape of stop 145, which may be positioned around and / or secured to tube 147, as described in more detail below and shown in FIG. 1F.

[0043] 1I and 1K, in some implementations, cover 120 includes hooks 197 configured to engage with notches 199 (see FIG. 1Z ) in hub 160. Hooks 197 may extend outward from a portion of cover 120, such as from wall 123 b. In some implementations, hooks 197 extend outward from an edge of wall 123 b. Alignment and / or positioning of hooks 197 within notches 199 can help align and / or position cover 120 relative to hub 160 when secured to hub 160.

[0044] The cover 120 may be coupled (e.g., movably coupled) to the extension set 140 in a manner similar to or identical to that described in U.S. Patent No. 6,266,999, with reference to any of the covers and extension sets disclosed in U.S. Patent No. 6,266,999. In such implementations in which the cover 120 is configured to move (e.g., slide) along the tube 147, the alignment and / or positioning of the hooks 197 within the notches 199 can help align and / or position both the cover 120 and the extension set 140 when, for example, the cover 120 is moved along the tube 147 and secured to the hub 160 after the connector 143 is secured to the catheter hub 142. Referring to FIG. 1Z , in some implementations, the notches 199 are formed by walls 199 a and / or grooves 199 b in portions of the membrane 162 that are spaced apart from one another by a gap. In some implementations, the notches 199 are additionally formed by a curved portion 199 c of the frame 164. In some implementations, the hook 197 has a size and / or shape that corresponds to the space defined by the wall 199a, the groove 199b, and / or the curved portion 199c.

[0045] FIG. 1L shows an exploded view of extension set 140. Extension set 140 (which may also be referred to as a "fluid tube assembly") can utilize and / or interact with cover 120 and / or hub 160 in a manner similar to that described with respect to the extension set in U.S. Patent Application Publication No. 2009 / 022999. Extension set 140 can include connector 143, stop 145, gasket 149, connector 146, tubing 147, and connector 148. Connector 143 can be configured to secure to catheter hub 142 to facilitate fluid communication between catheter hub 142 (and connected catheter 141) and tubing 147. Connector 143 can be a male Luer connector. Connector 148 can be configured to connect to a fluid delivery device. Connector 148 can be a female Luer connector. In some implementations, connector 146 and / or gasket 149 are the only components of extension set 140 that are movable relative to tubing 147.

[0046] In some implementations, stop 145 is permanently secured (e.g., bonded) to tube 147. Stop 145 may have an opening sized and shaped to receive tube 147. In some implementations, stop 145 has a tapered shape. In some implementations, stop 145 has a frusto-conical shape. Stop 145 may have a size and / or shape that corresponds to the size and / or shape of opening 133 in cover 120 (see FIGS. 1F and 1J). As shown in FIG. 1F, stop 145 can fit within opening 133 in cover 120. Stop 145 can be positioned within opening 133 when cover 120 is secured to hub 160 and / or when connector 146 (and gasket 149) is secured to connector 131 of cover 120 (e.g., via threaded portion 131b). Stop 145 can inhibit or prevent tube 147 from being pulled out of cover 120 and / or can isolate the portion of tube 147 within cover 120, connector 143, catheter hub 142, and / or catheter 141 from forces applied to tube 147 outside of cover 120. For example, if a force is applied to a portion of tube 147 outside of cover 120 in a direction along the longitudinal axis of tube 147 and / or transversely (e.g., perpendicularly) to such axis, stop 145 can engage wall 123b and prevent such force from causing movement of connector 143, catheter hub 142, and / or catheter 141. Stop 145 can be utilized alone or in combination with gasket 149, which is described below. In some cases, stop 145 can be engaged when the force applied to tube 147 exceeds the ability of gasket 149 to resist such force.

[0047] 1L and 1F , extension set 140 can include gasket 149 and connector 146. Connector 146 can be a spin-lock connector configured to connect to a threaded connector, such as threaded portion 131b of cover 120. Gasket 149 (e.g., a portion thereof) can be positioned within connector 146, such as around tube 147. Gasket 149 can be operably positioned by connector 146 such that pressure is applied to gasket 149 when connectors 146, 131 are secured to one another (see FIG. 1F ). When connectors 146, 131 are connected to one another, movement of connector 146 and cover 120 along tube 147 can be inhibited (e.g., prevented) via a gripping force applied by gasket 149 to tube 147 caused by pressure applied to gasket 149 by connectors 146, 131. Such a configuration allows the connectors 146, 131 to "lock" a portion of the tube 147 so that a force applied to the tube 147 outside the cover 120 is not transmitted to the portion of the tube 147 inside the cover 120, the connector 143, the catheter hub 142, and / or the catheter 141. This can advantageously prevent movement of the catheter 141 and / or the catheter hub 142. The gasket 149 (e.g., a portion thereof) can have a tubular and / or frustoconical shape. The gasket 149 can move (e.g., slide) along the tube 147 when the connector 146 is disconnected from the connector 131 of the cover 120. The gasket 149 can have a length that is shorter than the tube 147. The gasket 149 can be made from a variety of materials, such as polyvinyl chloride (PVC), latex-free materials, and / or other materials. Gasket 149 may comprise the same material as tube 147 or may comprise a different material than tube 147 .

[0048] The catheter stabilization device 100 may be utilized at a catheter insertion site to secure a catheter hub 142 as the catheter 141 is inserted at the catheter insertion site. The catheter stabilization device 100 may be secured to the skin of a portion of the subject's body (e.g., an arm) and may also be secured to such a catheter hub 142. By securing the catheter hub 142, the catheter stabilization device 100 stabilizes (e.g., operatively positions) the catheter 141 relative to the catheter insertion site and / or relative to the subject's blood vessel through which the catheter 141 extends. In some cases, movement of the catheter stabilization device 100 (and / or the skin to which the device 100 is attached) may cause the catheter 141 to move relative to the catheter insertion site and / or relative to the subject's blood vessel through which the catheter 141 extends. As previously discussed, it may be desirable to prevent relative movement between the catheter 141 and the subject's blood vessel and / or insertion site. As also discussed, it may be desirable to accommodate minor movement of the catheter 141 within the blood vessel. The catheter stabilization device 100 may include a first portion configured to be secured to the subject's skin and a second portion configured to be secured to a catheter hub 142 connected to a catheter 141. Such first and second portions may be movably coupled to one another to allow relative movement between the first portion and the catheter hub 142 and catheter 141. The membrane 162 and / or frame 164 described below may be an implementation of such a first portion. The catheter hub retainer 174, also described below, may be an implementation of such a second portion.

[0049] 1M-1BB illustrate a hub 160 or a portion thereof. The hub 160 (which may also be referred to as a "dock" or "base") may include a frame 164 and a membrane 162. In some implementations, the frame 164 includes a more rigid material than the membrane 162. In some implementations, the membrane 162 is overmolded onto the frame 164 in a manner similar to that described in U.S. Patent No. 6,622,613, for example, with reference to any of the membranes and frames disclosed in U.S. Patent No. 6,622,613. The frame 164 may include a frame body 170 and latch arms 173a, 173b, which may be similar to any of the frame bodies and latch arms (respectively) described in U.S. Patent No. 6,622,613. The latch arms 173a, 173b may engage with the protrusions 139a, 139b of the cover 120 in a manner similar to that described above. In some implementations, the membrane 162 is configured to be secured to the skin and is an adhesive layer (e.g., coupled with a foam layer) configured to be secured to the frame 164.

[0050] The membrane 162 may include one or more or multiple perforations 162a (also referred to herein as "openings") to facilitate breathing of the subject's skin when the membrane 162 is secured to the subject's skin. The membrane 162 may include an opening 163 that can be positioned over the site where the needle and / or catheter 141 is inserted (or was inserted) into the subject (e.g., a patient). The opening 163 may have a rounded shape. For example, the opening 163 may have an oval shape. In some implementations, the opening 163 is not bounded and / or divided by all portions of the membrane 162. In some implementations, when the catheter stabilization device 100 is assembled and secured to the subject's skin (e.g., as shown in FIG. 1F ), no portion of the membrane 162 is positioned between the catheter hub 142 and the subject's skin, between the connector 143 and the subject's skin, and / or between the catheter hub retainer 174 and the subject's skin. The membrane 162 may be made of a flexible material. The membrane 162 may be made of a different material than the cover 120. The membrane 162 may include, for example, a thermoplastic elastomer (TPE), a thermoplastic polyurethane (TPU), and / or polyvinyl chloride (PVC), among other materials. In some implementations, the membrane 162 includes a material that is more flexible than a material included by the cover 120. The membrane 162 may be more flexible than the frame 164. In some implementations, the membrane 162 is transparent or translucent. In some variations, the hub 160 does not include the frame 164. In some such variations, the hub 160 may be configured to removably connect to the cover 120.

[0051] The frame 164 may include one or more support portions extending from the frame body 170 that can assist in positioning the hub 160 relative to a catheter insertion site and / or relative to the catheter 141 and / or catheter hub 142. For example, the frame 164 may include fingers 175 extending outward from a surface of the frame body 170. As shown, the fingers 175 may extend toward each other from opposite sides of the frame body 170. The fingers 175 may be located closer to one of the two opposing ends of the hub 160 and / or frame 164. The fingers 175 may have a first end connected to a portion of the frame body 170 and a second end that is "free." The free ends of the fingers 175 may be spaced apart by gaps. Such gaps may allow the catheter insertion site to be viewed and positioned within the gaps, for example, when the hub 160 is secured to the subject's skin. In some implementations, fingers 175 (and / or other portions of hub 160) and / or cover 120 are made from a transparent material. In some such implementations, the free ends of fingers 175 are painted with a color that aids in the alignment and / or positioning of hub 160 (and fingers 175) relative to the catheter insertion site by making such free ends more readily visible.

[0052] FIG. 1M shows a top perspective view of hub 160 to which catheter hub 142 is secured. For hub 160 without catheter hub 142 and catheter 141, FIGS. 1N and 1O show top perspective views, FIG. 1P shows a bottom perspective view, FIG. 1Q shows a bottom view, and FIG. 1R shows a top view. As previously mentioned, hub 160 may include frame 170 and membrane 162. Hub 160 may further include catheter hub retainer 174 (which may also be referred to as a "catheter hub retainer"). Frame 164 and / or membrane 162 may be configured to be secured (e.g., removably secured) to the subject's skin, and catheter hub retainer 174 may be configured to be secured to catheter hub 142.

[0053] 1M-1R, the frame 164 may include one or more receiving portions 166 (e.g., two receiving portions). As previously mentioned, the frame 164 may include a frame body 170. In such implementations, the receiving portions 166 can extend from the frame body 170. In some implementations, the frame body 170 has an annular shape. In some implementations, the frame 164 includes two receiving portions 166 that extend outwardly toward each other from opposite sides (or portions) of the frame body 170 and / or that extend across an opening defined by the frame 164 and / or the opening 163 in the membrane 162. With reference to FIGS. 1V-1W, the catheter hub retainer 174 may include a body 174a and arms 174b that extend outwardly (e.g., in opposite directions from each other) from the body 174a. Each of the arms 174b may have a first end connected to the body 174a and a second end (which may be referred to as a "free end") opposite such first end. In some implementations, when the catheter stabilization device 100 (e.g., the frame 164 and / or the membrane 162) is secured to a subject, no portion of the catheter hub retainer 174 contacts the subject's skin. For example, in some implementations, when the catheter stabilization device 100 (e.g., the frame 164 and / or the membrane 162) is secured to a subject, the body 174a does not contact the subject's skin and / or the arms 174b do not contact the subject's skin.

[0054] 1S-1U show cross sections cut through a portion of the hub 160, as indicated in FIGS. 1M and 1R. The receiver 166 may include an interior 166i sized and / or shaped to receive at least a portion of the arm 174b of the catheter hub retainer 174. In some implementations, the frame 164 includes one receiver 166, and the catheter hub retainer 174 includes one arm 174b. In some implementations, the frame 164 includes two receivers 166, and the catheter hub retainer 174 includes two arms 174b, such as those shown in the figures. In some implementations where the frame 164 includes two receivers 166, these two receivers 166 are substantially aligned with one another (e.g., along an axis extending through the center of the interior 166i of the receiver 166). In some implementations, the arms 174b are substantially aligned with one another. The body 174a of the catheter hub retainer 174 can be configured to secure to the catheter hub 142. In some implementations, the body 174a comprises a C-shape. In some implementations, the body 174a is configured to surround at least about 25%, at least about 50%, or at least about 75% of the cross-section of the catheter hub 142. In some implementations, the body 174a is shaped to secure around a portion of the cylindrical cross-section of the catheter hub 142. In some implementations, the body 174a is shaped to surround less than the entire perimeter of the cross-section of the catheter hub 142 (e.g., the circular cross-section of the catheter hub 142). In some implementations, the body 174a is configured to not allow relative movement between the body 174a and the catheter hub 142 when secured together. In some implementations, the body 174a is configured to prevent inadvertent disconnection between the catheter hub retainer 174 and the catheter hub 142.

[0055] The catheter hub holder 174 can be movably coupled to the frame 164 and / or the membrane 162, for example, via the arm 174b and the receiver 166. FIGS. 1S-1U show reference axes 101, 103, and 105, which are perpendicular to one another. Referring to FIGS. 1R-1U, the width W1 of the hub 160 extends along the axis 105, and the length L1 of the hub 160 extends along the axis 103. The height of the hub 160 (and / or the catheter stabilization device 100) extends along the axis 101. FIGS. 1T-1U show cross-sectional views through the receiver 166 and the catheter hub holder 174. As shown, the interior 166i of the receiver 166 can have a height 166h and a width 166w. As also shown, the arm 174b can have a height 174h (which may be referred to as the thickness of the arm 174b) and a width 174w. Height 166h and height 174h extend along axis 101. Width 166w and width 174w extend along axis 105. In some implementations, height 174h is less than height 166h. Such implementations allow arms 174b (and catheter hub retainer 174) to move in one or both directions along axis 101 within interior 166i (see FIG. 1T). In some implementations, width 174w is less than width 166w. Such implementations allow arms 174b (and catheter hub retainer 174) to move in one or both directions along axis 105 within interior 166i (see FIG. 1U). In some implementations, distance 174d between the free ends of arms 174b is less than distance 166d between outer portions of interiors 166i of receiving portion 166 (see FIG. 1T). Such an implementation allows arm 174b (and catheter hub retainer 174) to move in one or both directions along axis 103.

[0056] In some implementations, arm 174b and receiver 166 are configured to permit relative movement (between catheter hub retainer 174 and frame 164 / membrane 162) about all of such axes 101, 103, and 105. In some variations, arm 174b and receiver 166 are configured to permit relative movement (between catheter hub retainer 174 and frame 164 / membrane 162) about only two of such axes 101, 103, and 105. For example, in some variations, height 174h is less than height 166h to permit movement of arm 174b along axis 101 within interior 166i, width 174w is less than width 166w to permit movement of arm 174b along axis 105 within interior 166i, and distance 174d is substantially equal to distance 166d to prevent movement of arm 174b along axis 103 within interior 166i. In some variations, width 174w is less than width 166w to permit movement of arm 174b along axis 105 within interior 166i, height 174h is substantially equal to height 166h to prevent movement of arm 174b along axis 101 within interior 166i, and distance 174d is less than distance 166d to permit movement of arm 174b along axis 103 within interior 166i. In some variations, distance 174d is less than distance 166d to permit movement of arm 174b along axis 103 within interior 166i, height 174h is less than height 166h to permit movement of arm 174b along axis 101 within interior 166i, and width 174w is substantially equal to width 166w to prevent movement of arm 174b along axis 105 within interior 166i.

[0057] In some variations, arm 174b and receiver 166 are configured to permit relative movement (between catheter hub retainer 174 and frame 164 / membrane 162) only about one of these axes 101, 103, 105. For example, in some variations, arm 174b and receiver 166 are configured to permit relative movement only along axis 101, only along axis 103, or only along axis 105. In some variations, height 174h is less than height 166h to permit movement of arm 174b along axis 101 within interior 166i, width 174w is substantially equal to width 166w to prevent movement of arm 174b along axis 105 within interior 166i, and distance 174d is substantially equal to distance 166d to prevent movement of arm 174b along axis 103 within interior 166i. In some variations, width 174w is less than width 166w to permit movement of arm 174b along axis 105 within interior 166i, height 174h is substantially equal to height 166h to prevent movement of arm 174b along axis 101 within interior 166i, and distance 174d is substantially equal to distance 166d to prevent movement of arm 174b along axis 103 within interior 166i. In some variations, distance 174d is less than distance 166d to permit movement of arm 174b along axis 103 within interior 166i, height 174h is substantially equal to height 166h to prevent movement of arm 174b along axis 101 within interior 166i, and width 174w is substantially equal to width 166w to prevent movement of arm 174b along axis 105 within interior 166i.

[0058] In some implementations, the catheter hub holder 174, the frame 164, and / or the membrane 162 are configured to allow relative rotation. For example, in some implementations, the catheter hub holder 174 may be configured to rotate relative to the frame 164 and / or the membrane 162. By way of example, the arm 174b (which may be connected to the body 174a) and the receiver 166 may be rotatably coupled to one another.

[0059] 1U, in some implementations, arm 174b is permitted to rotate within interior 166i, such as about an axis extending through arm 174b and / or interior 166i (e.g., parallel to axis 103). In some implementations, arm 174b can rotate within interior 166i about an axis extending through arm 174b and / or interior 166i by an amount that is between about 0 degrees and about 60 degrees, between about 0 degrees and about 55 degrees, between about 0 degrees and about 50 degrees, between about 0 degrees and about 45 degrees, between about 0 degrees and about 40 degrees, between about 0 degrees and about 35 degrees, between about 0 degrees and about 30 degrees, between about 0 degrees and about 25 degrees, between about 0 degrees and about 20 degrees, between about 0 degrees and about 15 degrees, between about 0 degrees and about 10 degrees, or between about 0 degrees and about 5 degrees. In some implementations, rotation of arm 174b within interior 166i, for example about an axis extending through arm 174b and / or interior 166i, is limited to an amount that is about 60 degrees or less, about 55 degrees or less, about 50 degrees or less, about 45 degrees or less, about 40 degrees or less, about 35 degrees or less, about 30 degrees or less, about 25 degrees or less, about 20 degrees or less, about 15 degrees or less, about 10 degrees or less, or about 5 degrees or less. Arm 174b can be sized and / or shaped relative to the size and / or shape of interior 166i of receiving portion 166 such that rotation of arm 174b within interior 166i is limited to the above amounts. In some implementations, arm 174b has a non-circular shape (e.g., elliptical), and / or interior 166i has a non-circular shape (e.g., elliptical).

[0060] 1T, in some implementations, arm 174b is permitted to rotate within interior 166i relative to axis 105 (and / or an axis extending through the center of the cross-section of catheter hub holder 174). In some implementations, arm 174b can rotate within interior 166i relative to axis 105 (and / or an axis extending through the center of the cross-section of catheter hub holder 174) by an amount that is between about 0 degrees and about 60 degrees, between about 0 degrees and about 55 degrees, between about 0 degrees and about 50 degrees, between about 0 degrees and about 45 degrees, between about 0 degrees and about 40 degrees, between about 0 degrees and about 35 degrees, between about 0 degrees and about 30 degrees, between about 0 degrees and about 25 degrees, between about 0 degrees and about 20 degrees, between about 0 degrees and about 15 degrees, between about 0 degrees and about 10 degrees, or between about 0 degrees and about 5 degrees. In some implementations, rotation of arm 174b within interior 166i relative to axis 105 (and / or an axis extending through the center of the cross section of catheter hub holder 174) is limited to an amount that is less than or equal to about 60 degrees, less than or equal to about 55 degrees, less than or equal to about 50 degrees, less than or equal to about 45 degrees, less than or equal to about 40 degrees, less than or equal to about 35 degrees, less than or equal to about 30 degrees, less than or equal to about 25 degrees, less than or equal to about 20 degrees, less than or equal to about 15 degrees, less than or equal to about 10 degrees, or less than or equal to about 5 degrees.

[0061] 1T, in some implementations, arm 174b is permitted to rotate within interior 166i relative to axis 101. In some implementations, arm 174b can rotate within interior 166i relative to axis 101 by an amount that is between about 0 degrees and about 60 degrees, between about 0 degrees and about 55 degrees, between about 0 degrees and about 50 degrees, between about 0 degrees and about 45 degrees, between about 0 degrees and about 40 degrees, between about 0 degrees and about 35 degrees, between about 0 degrees and about 30 degrees, between about 0 degrees and about 25 degrees, between about 0 degrees and about 20 degrees, between about 0 degrees and about 15 degrees, between about 0 degrees and about 10 degrees, or between about 0 degrees and about 5 degrees. In some implementations, rotation of arm 174b relative to axis 101 within interior 166i is limited to an amount that is about 60 degrees or less, about 55 degrees or less, about 50 degrees or less, about 45 degrees or less, about 40 degrees or less, about 35 degrees or less, about 30 degrees or less, about 25 degrees or less, about 20 degrees or less, about 15 degrees or less, about 10 degrees or less, or about 5 degrees or less.

[0062] In some implementations, rotation of arm 174b about axis 101 and / or 103 within interior 166i is allowed (e.g., up to any of the values ​​or ranges above), and rotation of arm 174b about axis 105 within interior 166i is limited to an amount that is equal to or less than one of the values ​​above. In some implementations, rotation of arm 174b about axis 101 and / or 105 within interior 166i is allowed (e.g., up to any of the values ​​or ranges above), and rotation of arm 174b about axis 103 within interior 166i is limited to an amount that is equal to or less than one of the values ​​above. In some implementations, rotation of arm 174b about axis 103 and / or 105 within interior 166i is allowed (e.g., up to any of the values ​​or ranges above), and rotation of arm 174b about axis 101 within interior 166i is limited to an amount that is equal to or less than one of the values ​​above. In some implementations, rotation of arm 174b within interior 166i is only permitted about one of axes 101, 103, and 105. For example, in some implementations, rotation of arm 174b within interior 166i is only permitted about axis 103. By allowing rotation about axis 102, catheter hub 142 and catheter 141 can have a self-adjusting tilt relative to the skin surface and / or catheter insertion site.

[0063] 1X and 1Y show additional implementations of catheter hub retainers 174', 174" that may include a body 174a', 174a" and arms 174b', 174b". The body 174a', 174a" can have a different size and / or shape than the body 174a, for example, to allow for fixation to catheter hubs having different sizes and / or shapes. The arms 174b', 174b" can have different lengths to accommodate bodies 174a', 174a" of different sizes / shapes and to allow the catheter hub retainers 174', 174" to be utilized with the receiving portion 166. The body 174a can be smaller or larger than the body 174a'. The arms 174b can be smaller or larger than the arms 174b". A kit (which may also be referred to as an "assembly") may include a frame 164 and / or a membrane 162 and multiple catheter hub holders (two or more catheter hub holders 174, 174', 174'', etc.) having different sizes and / or shapes corresponding to different sizes and / or shapes of catheter hubs, wherein the frame 164 and / or membrane 162 (e.g., receiving portion 166) is configured to be removably coupled (e.g., movably coupled and / or rotatably coupled as described herein) to each of the multiple catheter hub holders.

[0064] As discussed above, catheter stabilization device 100 may include a first portion configured to secure to a subject's skin and a second portion configured to secure to a catheter hub 142 coupled to a catheter 141 configured for insertion at a catheter insertion site. As also discussed above, frame 164 and / or membrane 162 may be implementations of such a "first portion," and catheter hub retainer 174 may be implementations of such a "second portion." While frame 164 is described above as having receiving portion 166 and catheter hub retainer 174 is described above as having arm 174b, in some variations, frame 164 has an arm (which may be similar to or identical to arm 174b) and catheter hub retainer 174 has a receiving portion (which may be similar to or identical to receiving portion 166). Figures 1AA-1BB show implementations of such variations. As shown, frame 164′ (which may be similar to frame 164) includes arms 174b′ extending (e.g., toward each other) from a portion of frame body 170′. Frame body 170′ may be similar to or identical to frame body 170. FIGS. 1AA-1BB also show an alternative implementation of catheter hub retainer 174′″ that includes body 174a′″ (which may be similar to body 174a) and receiver 166′ extending (e.g., in the opposite direction) from body 174a′″. As shown, arm 174b′″ of frame 164′ may be at least partially positioned within interior 166i′ of receiver 166′. The movement and / or rotation of arm 174b′″ and receiver 166′ may be similar to or identical to that described and / or illustrated herein with respect to arm 174b and receiver 166. The dimensions and / or characteristics (e.g., shape) of arm 174b''' can be similar to or identical to the dimensions and / or characteristics of arm 174b described above, and the dimensions and / or characteristics (e.g., shape) of receiving portion 166' (e.g., interior 166i') can be similar to or identical to the dimensions and / or characteristics (e.g., shape) of receiving portion 166 (e.g., interior 166i) described above.

[0065] As previously mentioned, the present disclosure provides devices having a first portion securable to a subject's skin and a second portion capable of stabilizing (e.g., operatively positioning) an inserted catheter at a catheter insertion site. As also described herein, such first and second portions may be movably coupled to one another to allow relative movement between the first portion (secured to the subject's skin) and the catheter hub and connected catheter. Allowing relative movement between such a first portion and the catheter hub and connected catheter can further inhibit relative movement between the catheter and the blood vessel and / or catheter insertion site, which may be desirable for reasons previously described. While the various devices disclosed herein are described with reference to catheters and catheter hubs, the present disclosure extends beyond this specific context. The present disclosure contemplates devices capable of securing other types of components (such as medical components) to a subject and allowing relative movement between the secured component and the portion of the subject's body to which the device is secured. For example, the present disclosure contemplates a device having a first portion that can be secured to the skin at a portion of a subject's body (e.g., at or near any of various open wound sites on the subject's body), and a second portion movably coupled to such first portion and configured to secure to a component such as a tube, wire (such as an ECG wire), blood glucose measuring device, catheter, or the like, intended for insertion into a blood vessel or through the skin into another area of ​​the subject's body (such as a kidney), among other components. Such a component to which the second portion secures may be a partially implantable device. Such "first" and "second" portions of the device may be similar to any of the implementations described herein with respect to catheter hub retaining portion 174 and receiving portion 166.

[0066] FIG. 2A shows a top perspective view of electronic device 200. Electronic device 200 connects (e.g., removably connects) to any of the catheter stabilization devices disclosed herein. Electronic device 200 may include various electronic components, such as those described further below. FIG. 2D shows a bottom view of electronic device 200. Electronic device 200 may include a housing with upper and lower shells 200a and 200b that may at least partially enclose and / or protect all of the electronic components contained within the housing. Such a housing may be waterproof, which advantageously allows electronic device 200 to be wiped down with and / or immersed in a disinfectant without the disinfectant reaching the electronic components of electronic device 200. FIG. 2C shows a bottom view of electronic device 200 with lower shell 200b removed.

[0067] 3A-3B show perspective and top views (respectively) of another implementation of cover 320. Cover 320 may be similar or identical in some or many respects to any of the covers disclosed herein. Cover 320 may include a top portion 323a, walls 323b, wings 322, and / or a connector 331 including a connector body 331a and a threaded portion 331b. Top portion 323a, walls 323b, wings 322, connector 331, connector body 331a, and threaded portion 331b may be similar or identical to top portion 123a, walls 123b, wings 122, connector 131, connector body 131a, and threaded portion 131b of cover 120. Cover 320 may be configured to removably connect to electronic device 200. For example, in some implementations, the cover 320 includes one or more (e.g., one, two, three, four, five, or six) cavities 391a configured to receive one or more (e.g., one, two, three, four, five, or six) pins 220 of the electronic device 200 ( FIGS. 2C-2D ). The engagement between the pins 220 and the cavities 391a can be, for example, a press-fit engagement. FIGS. 3C-3D show how the electronic device 200 and the cover 320 can be connected together via the pins 220 and the cavities 391a. In some variations, the electronic device 200 includes one or more cavities (which can be similar to or identical to the cavities 391a), and the cover 320 includes one or more pins (which can be similar to or identical to the pins 220), which can be secured to one another.

[0068] In addition to, or as an alternative to, pins 220 and cavities 391a, electronic device 200 and cover 320 may be configured to slidably connect to one another. For example, in some implementations, cover 320 includes one or more grooves 391b (such as one or two grooves 391b), and electronic device 200 includes one or more protrusions (e.g., along the periphery of electronic device 200 or its housing) that can slidably engage with such grooves 391b. Such grooves 391b may be positioned on or near opposing portions of wall 323b and / or near where top portion 323a joins wall 323b. Such grooves 391b may comprise a tapered profile. In some variations, electronic device 200 includes one or more grooves (which may be similar or identical to grooves 391b), and cover 320 includes one or more protrusions that can slidably engage with such grooves. Although such cavities 391a and grooves 391b are described in connection with cover 320, any of the other covers disclosed herein may incorporate such cavities 391a and / or grooves 391b for connection to electronic device 200.

[0069] 2B shows a schematic diagram of an example electronic device 200. The electronic device 200 may include a processing unit (or one or more processing units) 202 and a communications module 210. In some implementations, the electronic device 200 includes a battery 212. In some variations, the electronic device 200 does not include a battery but receives power from an external power source (e.g., via a cable). In some implementations, the electronic device 200 includes a camera 204, one or more light sources 206, and / or one or more sensors 208 (such as physiological measurement sensors). In some implementations in which the electronic device 200 includes a battery 212, the electronic device 200 is configured to enable wireless charging (e.g., inductive charging) of the battery 212. In some implementations, the electronic device 200 includes a connector port configured to electrically connect to a connector port of an external device (e.g., for charging and / or communication). 2A and 2C show example electrical components 201 that may be associated with (or connected to) an external device at a location within a portion of the housing (e.g., outer shell 200a). FIG. 2D shows electronic device 200 without electrical components 201 shown. In some implementations, electronic device 200 is configured for both wireless and wired communication with external devices. Such implementations can provide a form of redundancy for communication if one of such communication methods is impaired.

[0070] Processing unit 202 is configured to, among other things, process data, execute instructions to perform one or more functions, and / or control the operation of electronic device 200. For example, processing unit 202 may process data obtained from electronic device 200 (e.g., from camera 204 and / or sensor 208) and may execute instructions to perform functions related to storing and / or transmitting such data.

[0071] The communications module 210 can facilitate communication (via wired and / or wireless connections) between the electronic device 200 (and / or its components) and a separate electronic device, such as another monitoring device and / or a mobile device. For example, the communications module 210 can be configured to enable the electronic device 200 to wirelessly communicate with other devices, systems, and / or networks over any of a variety of communications protocols. The communications module 210 can be configured to use any of a variety of wireless communications protocols, such as Wi-Fi (802.11x), Bluetooth, ZigBee, Z-wave, cellular, infrared, near field communication (NFC), RFID, satellite transmission, proprietary protocols, and combinations thereof. The communications module 210 can enable data and / or instructions to be transmitted to and / or received from the electronic device 200 and another external computing device. The communications module 210 may be configured to transmit (e.g., wirelessly) processed and / or unprocessed data (e.g., from the camera 204 and / or the sensor 208) or other information to a separate computing device, which may include, among other things, a mobile device (e.g., an iOS or Android-enabled smartphone, tablet, laptop computer), desktop computer, server, or other computing or processing device for display and / or further processing. Such a separate computing device may be configured to store and / or further process the received data and / or information indicative of or derived from the received data, and / or to transmit data (including displays, alerts, warnings, and notifications) to various other types of computing devices and / or systems that may be associated with a hospital, caregiver (e.g., a primary care provider), and / or user that have permission to access the subject's data.As another example, communication module 210 of electronic device 200 may be configured to wirelessly transmit processed and / or unprocessed data to a separate computing device that may include one or more processing units configured to execute applications that generate graphical user interfaces that display data and / or other information obtained from electronic device 200.

[0072] Electronic device 200 may be configured to connect (e.g., removably connect) to any of the catheter stabilization devices disclosed herein. As discussed herein, electronic device 200 may be configured to connect to cover 320. Camera 204 may be configured to generate visual signals (e.g., images) of the catheter insertion site, the catheter inserted at the catheter insertion site, the catheter hub, and / or any other area near any of these, and / or any other area enclosed by cover 320 to which electronic device 200 is secured. In some implementations, processing unit 202 is configured to receive such visual signals from camera 204 and to determine the status (which may be referred to as the "current status") of the catheter insertion site, the catheter, and / or the catheter hub. Such a determination may involve comparing the visual signals generated by camera 204 at a first time period with the visual signals generated by camera 204 at a second time period. Additionally or alternatively, such a determination may involve comparing the visual signals generated by camera 204 at one or more time periods with one or more visual signals (e.g., images) in a database. Such a database can store, for example, multiple images of catheter insertion sites and / or multiple images of the relative positioning of catheters and / or catheter hubs, and such a database can be used as a reference point. In some implementations, the visual signals generated by camera 204 are transmitted (e.g., wirelessly), for example, via communications module 210, to an external device for analysis. One or more processing units in such an external device can be configured to operate in a manner similar or identical to that described above with respect to processing unit 202.Whether the determination of the status of the catheter insertion site, catheter, and / or catheter hub is made by the electronic device 200 or by an external device in communication with the electronic device 200, the visual signal generated by the camera 204 can be utilized not only for real-time visualization / viewing by a caregiver (or other person), but can also be utilized to diagnose infections in their early stages (in an automated manner) and / or to assess whether attention should be given to the catheter, catheter insertion site, and / or catheter hub (e.g., repositioning and / or repositioning any of them).

[0073] In some implementations, the electronic device 200 includes one or more light sources 206 configured to emit light of one or more wavelengths at and / or toward a catheter insertion site, a catheter inserted at the catheter insertion site, a catheter hub, and / or any other area near any of these, and / or any other area enclosed by a cover to which the electronic device 200 is secured. Such light sources 206 may include one or more broad-spectrum LEDs configured to emit light having wavelengths between a first range, one or more narrow-spectrum LEDs configured to emit light having wavelengths between a second range smaller than the first range, and / or one or more ultraviolet LEDs. Such first range may be, for example, between about 380 nm and about 740 nm. Such ultraviolet LEDs may include one or more ultraviolet-A LEDs, one or more ultraviolet-B LEDs, and / or one or more ultraviolet-C LEDs. In some implementations, the one or more ultraviolet-A LEDs are configured to emit light at a wavelength between about 320 nm and about 400 nm, the one or more ultraviolet-B LEDs are configured to emit light at a wavelength between about 290 nm and about 320 nm, and the one or more ultraviolet-C LEDs are configured to emit light at a wavelength between about 200 nm and about 280 nm. The inclusion of one or more ultraviolet LEDs, such as any of ultraviolet-A LEDs, ultraviolet-B LEDs, and / or ultraviolet-C LEDs, can provide sterilization of the catheter insertion site, catheter, catheter hub, and / or other nearby areas.

[0074] The inclusion of any of the above-described broad-spectrum and / or narrow-spectrum LEDs can be utilized to determine physiological parameters such as blood oxygen saturation and / or pulse rate, for example, if electronic device 200 includes one or more detectors (which may be part of sensor 208) configured to detect the emitted light after it has attenuated through skin tissue. Additionally or alternatively, such LEDs can be used to illuminate different colors that can be utilized to gather additional visual data points with images being acquired using camera 204. For example, visual data can be acquired using camera 204 over one or more time periods during which such LEDs provide illumination of different colors, and images acquired using the different colors can enable additional analysis of the condition of the catheter insertion site, catheter, catheter hub, and / or other nearby areas.

[0075] Sensor 208 may include any of a variety of sensors for measuring one or more physiological parameters of the subject. For example, sensor 208 may include a temperature sensor (e.g., for determining skin temperature and / or the temperature in an area encompassed by any of the catheter stabilization devices to which electronic device 200 is secured), a humidity sensor, and / or a pulse oximetry sensor for determining pulse rate and / or blood oxygen saturation.

[0076] 2C-2D , electronic device 200 may include a circuit board 228, a camera 222 (which may be an implementation of camera 204), broad and / or narrow spectrum LEDs 226 (which may be an implementation of what was previously discussed with respect to light source 206), and / or ultraviolet LEDs 224 (which may be an implementation of what was previously discussed with respect to light source 206). Camera 222, LEDs 224, and / or LEDs 226 may be coupled to a surface of circuit board 228 such that they face toward a catheter insertion site, a catheter, a catheter hub, and / or skin that is enclosed and / or surrounded by a cover to which electronic device 200 is secured during use. In some implementations, camera 222 includes a wide-angle lens.

[0077] The cover 320 can be configured to at least partially enclose a catheter insertion site in a subject. With reference to FIGS. 3A-3D , the cover 320 can include an opening 399 configured to provide visibility of the catheter insertion site (and / or an inserted catheter or connected catheter hub) when the cover 320 is in use. In some implementations, a transparent material can be placed over the opening 399 to seal the enclosed area. In some implementations, the cover 320 includes a magnifying lens positioned within and / or across the opening 399. Such a magnifying lens can advantageously magnify the view of the catheter insertion site (and / or an inserted catheter or connected catheter hub) by two, three, or four times its actual size. While such openings 399 and magnifying lenses are described with respect to the cover 320, any of the other covers disclosed herein can incorporate such openings 399 and magnifying lenses. In some implementations, cover 320 is made from a transparent material that, when electronic device 200 is secured to cover 320 (e.g., top portion 323a of cover 320), allows camera 204 to interrogate and / or light source 206 to emit light at the catheter insertion site, catheter, catheter hub, and / or skin enclosed and / or surrounded by cover 320. Referring to Figures 3C-3D, in some implementations, electronic device 200 connects to a portion of cover 320 that is spaced from opening 399 so as not to interfere with viewing of the catheter insertion site, catheter, and / or catheter hub through opening 399 or a magnifying lens over opening 399.

[0078] 4A-4G show other implementations of the catheter stabilization device 400 and its various portions. The catheter stabilization device 400 (which may also be referred to as a "catheter housing," "catheter housing device," "catheter securement device," "catheter stabilization system," or "device") may be similar in some or many respects to the catheter stabilization device 100. FIGS. 4A-4B show top perspective views of the catheter stabilization device 400, and FIG. 4C shows a bottom perspective view of the catheter stabilization device 400. FIGS. 4D and 4E show top and bottom views (respectively) of the catheter stabilization device 400. FIG. 4F shows a cross-section taken through a portion of the catheter stabilization device 400 (as indicated in FIG. 4D) in an in-use configuration in which the device 400 is secured to the skin of a subject. While not shown in FIG. 4F, it will be understood that the catheter 441 may be at least partially positioned within a blood vessel of a subject when in use. FIG. 4G shows an exploded view of the catheter stabilization device 400 adjacent to the catheter 441 and catheter hub 442. The catheter 441 can be similar to or identical to the catheter 141, and the catheter hub 442 can be similar to or identical to the catheter hub 142. Referring to FIG. 4G, the catheter stabilization device 400 can include a cover 420 and a hub 460. In some implementations, the catheter stabilization device 400 includes an extension set 440. In some implementations, the cover 420 and the extension set 440 are coupled to one another, for example, in a manner similar to that described with respect to any of the covers and extension sets in U.S. Patent No. 6,274,999. In some variations, the catheter stabilization device 400 includes the hub 460 (or hub 460′ or hub 460″, each of which is described further below), but does not include the cover 420 and / or does not include the extension set 440. In some variations, the catheter stabilization device 400 includes the cover 420, but does not include the hub 460 and / or does not include the extension set 440.

[0079] FIGS. 4H-4Q show views of cover 420. FIGS. 4H-4I and 4K show top perspective views of cover 420, and FIG. 4J shows a bottom perspective view of cover 420. FIGS. 4L and 4M show top and bottom views (respectively) of cover 420. FIGS. 4N and 4O show front and rear views (respectively) of cover 420. FIGS. 4P and 4Q show side views of cover 420. Cover 420 may be similar in some or many respects to cover 120. Cover 420 may include a top portion 423a, a wall 423b, and / or one or more wings 422 that may be similar in some, but not all, respects to top portion 123a, wall 123b, and / or wings 122 (respectively) of cover 120 described above. In some implementations, wing 422 includes opening 422a (which may be similar to or identical to opening 122a of wing 122). In some implementations, wing 122 includes one or multiple protrusions 422b that can assist a user in gripping cover 420. Cover 420 may include one or both ports 437a, 437b that may extend from a portion of cover 420, such as wall 423b (or alternatively, from top portion 423a). Ports 437a, 437b may be similar to or identical to ports 137a, 137b or any of the ports disclosed in U.S. Patent Application Publication No. 2010 / 022999. Referring to FIG. 4J, cover 420 may include openings 437c, 437d to facilitate fluid communication between ports 437a, 437b and an interior of cover 420 (e.g., an interior defined by top portion 423a and wall 423b). Cover 420 can be made from, for example, any of the materials described above with respect to cover 120. Cover 420 can be transparent or translucent and / or can be made from a more rigid material than membrane 462 of hub 460.

[0080] 4J , cover 420 may include an opening 433 that allows a fluid line to pass through cover 420 and catheter hub 442 (e.g., via connector 443). Cover 420 may include a connector 431 that may be similar in some respects to connector 131. Opening 433 extends through wall 423 b and connector 431 and may be sized and / or shaped to correspond to the size and / or shape of fluid line connector 445 (which may also be referred to as a “fitting”) to inhibit (e.g., prevent) rotation of connector 445, as described further below. Preventing rotation of connector 445 within opening 433 inhibits rotation of tubes 449, 447 (and / or any or all other components of extension set 440) that may be joined to connector 445, as described further below. Preventing rotation of tubes 449, 447 advantageously prevents rotation of connected components, such as connector 443, catheter hub 442, and catheter 441, when catheter stabilization device 400 is in use.

[0081] The cover 420 may include one or more features to enable securement to the hub 460. As shown in FIGS. 4H-4J, the cover 420 may include a protrusion 439a (see FIGS. 4H-4J) configured to secure the latch arm 473a (see FIGS. 4Y-4Z and 4CC-4DD) of the hub 460. In some implementations, the cover 420 includes a recessed portion 439b (e.g., at an edge of the cover 420), with the protrusion 439a positioned within such recessed portion 439b. The recessed portion 439b may be formed in the wall 423b, for example. As shown in FIGS. 4J-4K, the cover 420 may include a lip 497 having an opening 497a. The lip 497 may extend from a portion of the cover 420, such as from an edge of the wall 423b at the edge of the cover 420. Opening 497a may be configured to receive protrusion 473b (see FIGS. 4Z and 4CC-4DD) of hub 460. Protrusion 439a of cover 420 may be configured to removably secure to latch arm 473a of hub 460. Protrusion 473b of hub 460 may be configured to removably secure within opening 497a. The locking between protrusion 439a and latch arm 473a and / or the locking between protrusion 473b and opening 497a may removably secure cover 420 and hub 460 to one another. In some implementations, cover 420 may be disconnected from hub 460 by moving latch arm 473a out of engagement with protrusion 439a (and / or out of recessed portion 439b). After latch arm 473a disengages from protrusion 439a, cover 420 can be angled relative to hub 460 so that protrusion 473b disengages from opening 497a, allowing cover 420 to be removed from hub 460. In some implementations, cover 420 and hub 460 can form an airtight seal around the catheter insertion site when device 400 is in use.

[0082] The cover 420 may be coupled (e.g., movably coupled) to the extension set 440 in a manner similar to that described in U.S. Patent No. 6,277,623, with reference to any of the covers and extension sets disclosed therein. FIG. 4G shows a perspective view of the extension set 440 (with the cover 420, hub 460, catheter 441, and catheter hub 442), and FIG. 4R shows an enlarged view of a portion of the extension set 440. The extension set 440 (which may be referred to as a "fluid conduit assembly") may utilize and / or interact with the cover 420 and / or hub 460 in a manner similar to that described with respect to the extension set in U.S. Patent No. 6,277,623. The extension set 440 may include a connector 443, a connector 445 (which may also be referred to as a "fitting"), a first fluid conduit 449, a connector 446, a second fluid conduit 447, a connector 448, and a sealing member 445g. Connectors 443, 448, and tubing 447 may be similar to or identical to connectors 143, 148, and tubing 147 (respectively) described above. Connector 443 (which may be a male luer connector) may be configured to secure to catheter hub 442 to facilitate fluid communication between catheter hub 442 (and connected catheter 441) and tubing 449, 447. Connector 448 (which may be a female luer connector) may be configured to connect to a fluid delivery device. Connector 446 may be configured to removably secure to fitting 445, for example, via engagement between threads in connector 446 and threads 445b in fitting 445. Connector 446 can be secured to fitting 445 after fitting 445 is positioned within opening 433, after connector 443 is secured to catheter hub 442, and / or after cover 420 is secured to hub 460 (see FIG. 4F ). Figure 4S shows connector 446 not secured to fixture 445, while Figure 4R shows connector 446 secured to fixture 445 (cover 420 is also not shown). Figure 4F shows connector 446 and fixture 445 secured to each other and to cover 420. Figure 4T shows a side view of fixture 445, and Figures 4U-4V show perspective views of fixture 445.

[0083] The fitting 445 can fluidly couple the tubes 447 and 449 together. The fitting 445 can include a first interior portion 445c configured to receive the tube 447 and a second interior portion 445e configured to receive the tube 449. The tubes 447, 449 can be permanently secured (e.g., bonded) to the fitting 445, for example, within such interior portions 445c, 445e. The fitting 445 can include an interior wall 445d separating the interior portions 445c, 445e (see FIGS. 4U-4V and 4F). The interior wall 445d can act as an abutment surface for the ends of the tubes 447, 449. The interior wall 445d can include an opening (e.g., a circular opening shown in FIG. 4V) that can facilitate fluid communication between the tubes 447, 449. The fitting 445 may include one or more (e.g., a number) of features configured to mate with corresponding features in the opening 433 of the cover 420. Such corresponding mating features can inhibit (e.g., prevent) rotation of the fitting 445 relative to the opening 433 and the cover 420. For example, the fitting 445 may include one or more ribs 445a (see FIGS. 4R-4U) sized and shaped to match the size and shape of one or more grooves (see FIGS. 4J-4K) extending in the opening 433 / connector 431. Such corresponding mating features can inhibit rotation of the fitting 445 relative to the cover 420, which in turn inhibits rotation of the components of the extension set 440 relative to the cover 420. This can further advantageously prevent rotation of the catheter hub 442 and / or catheter 441 when the extension set 440 is connected to the catheter hub 442 (e.g., via connector 443), which prevents movement of the catheter 441 within the subject's vasculature and at the catheter insertion site. The extension set 440 can include a sealing member 445g, such as, for example, an O-ring, which can be held in place by a rim 445f at the end of the fitting 445. The sealing member 445g can seal the opening 433 in the cover 420 (e.g., at an interior portion of the cover 420) when the extension set 440 and cover 420 are secured together, as shown, for example, in FIG. 4F .

[0084] As discussed above, extension set 440 can include two fluid conduits, conduit 447 and conduit 449. Including both fluid conduits 449 and 447 in extension set 440 provides several advantages. FIG. 4F shows a cross section taken through cover 420, hub 460, and extension set 440 when secured together to catheter hub 442. In some implementations, fluid conduit 449 is made from a flexible material. This advantageously allows conduit 449 to bend and accommodate movement of catheter hub retainer 474 (and connected catheter hub 442), as described above, even when extension set 440 is secured to cover 420 and hub 460. In some implementations, fluid conduit 449 is made from a more flexible material than the material from which fluid conduit 447 is made. In some implementations, conduit 447 is more durable than conduit 449. This advantageously allows the tube 447 to withstand forces and / or stresses (e.g., due to tensile or torsional forces) to which the tube 447 may be exposed in the catheter stabilization device 400 and the environment surrounding the catheter insertion site in the subject.

[0085] The catheter stabilization device 400 may be utilized at a catheter insertion site to secure a catheter hub 442 as the catheter 441 is inserted at the catheter insertion site. The catheter stabilization device 400 may be secured to the skin of a portion of the subject's body (such as the arm) and may also be secured to such a catheter hub 442. By securing the catheter hub 442, the device 400 stabilizes (e.g., operatively positions) the catheter 441 relative to the catheter insertion site and / or relative to the subject's blood vessel through which the catheter 441 extends. In some cases, movement of the catheter stabilization device 400 (and / or the skin to which the device 400 is attached) may cause the catheter 441 to move relative to the catheter insertion site and / or relative to the subject's blood vessel through which the catheter 441 extends. As previously discussed, it may be desirable to prevent relative movement between the catheter 441 and the subject's blood vessel and / or insertion site. The catheter stabilization device 400 may include a first portion configured to be secured to the subject's skin and a second portion configured to be secured to a catheter hub 442 connected to a catheter 441. Such first and second portions may be movably coupled to one another to allow relative movement between the first portion and the catheter hub 442 and catheter 441. The membrane 462, frame 464, and / or clamp 466, described below, may be implementations of such a first portion. The membrane 462′, frame 464′, and / or clamp 466′, described further below, may also be implementations of such a first portion. The membrane 462″, frame 464″, and / or clamp 466″, described further below, may also be implementations of such a first portion. The catheter hub retainers 474, 474′, 474″, also described below, may each be implementations of such a second portion.

[0086] FIGS. 4W-4X show top perspective views of a catheter hub 442 and a hub 460 secured to a catheter 441. FIGS. 4Y-4RR show the hub 460, or a portion thereof. The hub 460 (which may also be referred to as a "dock" or "base") may be similar in some or many respects to the hub 160. The hub 460 may include a frame 464 and a membrane 462. In some implementations, the frame 464 includes a more rigid material than the membrane 462. In some implementations, the membrane 462 is overmolded onto the frame 464 in a manner similar to that described in U.S. Patent No. 5,623,669, for example, with reference to any of the membranes and frames disclosed in U.S. Patent No. 5,623,669. In some implementations, the membrane 462 is an adhesive layer (e.g., coupled with a foam layer) configured to secure to the skin and to the frame 464. The frame 464 may include a frame body 470 and a latch arm 473a extending from the frame body 470. Frame body 470 may be similar to frame body 170. Latch arm 473a may be configured to secure (e.g., removably secure) to protrusion 439a of cover 420, as previously discussed. In some implementations, latch arm 473a (e.g., an end of latch arm 473a) is sized and / or shaped to fit within recessed portion 439b of cover 420 to minimize or eliminate the possibility of inadvertently snagging on wires, tubing, clothing, or other objects in the vicinity around catheter stabilization device 400 when in use on a subject and / or in a medical environment. In some implementations, membrane 462 is an adhesive layer (e.g., coupled with a foam layer) configured to secure to skin and to frame 464. Membrane 462 may include one or more or multiple perforations 462a, which may be identical to perforations 162a. Membrane 462 may be similar to or identical to membrane 162 in some or all respects.

[0087] The frame 464 may include one or more support portions extending from the frame body 470 that can assist in positioning the hub 460 relative to a catheter insertion site and / or relative to the catheter 441 and / or catheter hub 442. For example, the frame 464 may include fingers 475 extending outward from a surface of the frame body 470. As shown, the fingers 475 may extend toward each other from opposite sides of the frame body 470. The fingers 475 may have a first end connected to a portion of the frame body 470 and a second end that is "free." The free ends of the fingers 475 may be spaced apart by gaps. Such gaps may allow the catheter insertion site to be viewed and positioned within the gaps, for example, when the hub 460 is secured to the subject's skin. In some implementations, such free ends of the fingers 475 are tapered. In some implementations, the hub 460 (e.g., the frame 464, the membrane 462, and / or the cover 420) are made from a transparent material. In some implementations in which the fingers 475 are made from a transparent material, the free ends of the fingers 475 are painted with a color that aids in aligning and / or positioning the hub 460 (and the fingers 475) relative to the catheter insertion site by making such free ends more readily visible. As mentioned elsewhere herein, the membrane 462 may be overmolded onto the frame 464. In some implementations, the frame 464 includes one or more features that can facilitate bonding of the membrane 462 to the frame 464. For example, with reference to FIG. 4HH, the frame 464 may include one or multiple grooves 499 in the frame body 470 that can facilitate bonding of the membrane 462. Such grooves 499 can be spaced apart from one another and positioned on the outer surface of the frame body 470. In some implementations, the grooves 499 are disposed along the entire periphery of the frame body 470.

[0088] 4W-4X show top perspective views of the hub 460 with the catheter hub 442 secured thereto, and FIGS. 4Y-4Z show top perspective views of the hub 460 without the catheter hub 442. For the hub 460, FIGS. 4AA shows a top view, 4BB shows a bottom view, 4CC-4DD show side views, 4EE shows a front view, and 4FF shows a rear view. As previously described, the hub 460 may include a frame 464 and a membrane 462. The hub 460 may also include a clamp 466 (which may also be referred to as a "clasp" or "boom") and a catheter hub retainer 474 (which may also be referred to as a "catheter hub retainer"). The frame 464, membrane 462, and / or clamp 466 (which may be connected to one another) may be configured to secure (e.g., removably secure) to the subject's skin (e.g., via the membrane 462). The catheter hub retainer 474 can be configured to secure to the catheter hub 442. As described in more detail below, the catheter hub retainer 474 can be movably coupled (e.g., rotatably coupled) to the membrane 462 and / or frame 464 via clamps 466.

[0089] The clamp 466 may be connected to one or more portions of the frame 464. For example, if the frame 464 has an annularly shaped frame body 470, the clamp 466 may be connected to both sides of the frame body 470, as shown. In implementations of the catheter stabilization device 400 that include both the frame 464 and the membrane 462, where the membrane 462 includes an opening 463, the clamp 466 can extend between two portions of the frame body 470, across the opening 463, and / or across the opening 463. In some implementations, the clamp 466 is configured to removably connect to the frame 464 (e.g., the frame body 470). For example, the clamp 466 may include a first end configured to connect to a first portion of the frame body 470 and a second end configured to connect to a second portion of the frame body 470. In some implementations, the clamp 466 is pivotally connected to the frame 464 (e.g., the frame body 470) and configured to pivot between a plurality of positions, as described further below.

[0090] Figures 4HH-4KK show, among other things, frame 464 and frame body 470 without membrane 462. Figures 4OO-4RR show top and bottom perspective views of clamp 466. In some implementations, clamp 466 includes pin 466a (e.g., at a first end of clamp 466). Pin 466a may be configured to be connected to a portion of frame body 470 in a manner that allows clamp 466 to pivot relative to frame 464. Frame 464 may be configured to be pivotally secured to pin 466a. For example, with reference to Figure 4JJ (showing an enlarged portion of frame 464), frame 464 may include one or both of hook 465a and / or protrusion 465b that may be configured to receive pin 466a such that pin 466a is fixed but allowed to pivot about an axis (which may be referred to as the "pin axis") extending through pin 466a. FIGS. 4W-4HH show clamp 466 in a first position, and FIG. 4II shows clamp 466 in a second position. Clamp 466 may be configured to be pivoted (about an axis extending through pin 466a) between multiple rotational positions, including, but not limited to, the positions shown in the figures. FIG. 4II may be an example of an “open” position of clamp 466 that may be utilized prior to securement of catheter hub 442 to catheter hub retainer 474. In some implementations, clamp 466 includes one or more protuberances 466g extending outward from pin 466a. Protuberances 466g may be configured to contact and / or engage protrusions 465b of frame 464 when clamp 466 is rotated (e.g., between the positions shown in FIGS. 4HH-4II). Protuberances 466g may at least partially inhibit rotation of clamp 466 and / or provide tactile feedback when clamp 466 is pivoted.

[0091] The clamp 466 may include one or more mechanical engagement features configured to secure the clamp 466 to the frame body 470. For example, with reference to FIGS. 4OO-4RR, the clamp 466 may include a latch portion 466b (which may also be referred to as a "latch") that can be secured to a latch protrusion 467a extending from the frame body 470. The latch portion 466b may be located at an end of the clamp 466, such as the end opposite the end at which the pin 466a is located. In some implementations, when the latch 466b is secured to the frame body 470, a portion of the latch 466b passes over the protrusion 467a such that the protrusion 467a bears against and / or contacts a ledge 469a of the latch 466b. With reference to FIG. 4GG, the protrusion 467a may prevent disconnection of the latch portion 466b from the frame 464, for example, preventing the clamp 466 from pivoting toward the position shown in FIG. 4II. In some implementations, latch portion 466b can include one or both of ridges 469b, 469c, and frame 464 can include one or both of protrusions 467c, 467d that can extend from frame body 470. Protrusions 467c, 467d can limit and / or prevent movement of latch portion 466b in a direction parallel to the side of frame 464, such as, for example, a direction parallel to an axis extending along width W2 (see FIG. 4AA) of hub 460. Protrusions 467c, 467d (which may also be referred to as “guiding protrusions” or “alignment protrusions”) can help guide latch portion 466b into engagement with protrusions 467a, 467b. 4KK and 4OO-QQ, the ridges 469b, 469c may be positioned adjacent to and / or contact the projections 467b extending from the frame body 470 when the latch portion 466b is secured to the frame 464 in the position shown in FIG. 4HH (which may be referred to as the "closed" position). In some implementations, the latch portion 466b may be removed from the frame 464 body by compressing the clamp 466 (e.g., inward).

[0092] The pivotable connection of clamp 466 to frame 464 (e.g., via pin 466a) advantageously allows catheter hub 442 to be efficiently and conveniently secured to catheter hub holder 474. For example, after catheter 441 is inserted into the insertion site and hub 460 is secured to the subject's skin around the insertion site, clamp 466 can be moved from a position such as the position shown in FIG. 4II (which is an example of an "open position" of clamp 466) to a position such as the position shown in FIG. 4HH (which is an example of a "closed position" of clamp 466). In this situation, clamp 466 can be pivoted to a closed position in a manner that secures catheter hub holder 474 to catheter hub 442. Pivoting clamp 466 to a closed position (e.g., a position in which latch portion 466b is secured to frame body 470) can move catheter hub holder 474 closer to the subject's skin and catheter hub 442. The catheter hub retainer 474 and the securing of the catheter hub retainer 474 to the catheter hub 442 are further described below.

[0093] While the above figures and descriptions illustrate and describe an implementation of clamp 466 including pin 466a and latch portion 466b, other implementations of clamp 466 are possible. For example, in some variations, clamp 466 does not include pin 466a but can still be configured to removably connect to frame 464, e.g., by having clamp 466 secure catheter hub retainer 474 to catheter hub 442. For example, in some variations, clamp 466 is configured to secure to two portions of frame body 470 (e.g., at or near the locations shown in the figures) via a connection (such as a press-fit and / or snap-fit ​​connection). For example, clamp 466 can be configured to have latch portions 466b at both ends of clamp 466, instead of having pin 466a at one end and latch portion 466b at the other end. In such variations, frame 464 may include protrusions 467a, 467b, 467c, and / or 467d on either side of frame body 470 to secure to both latch portions 466b of clamp 466. In such variations, clamp 466 (and catheter hub retainer 474) may be secured to frame body 470 across opening 463 and over catheter hub 442 so that catheter hub retainer 474 secures to catheter hub 442. In some variations, clamp 466 may be removably connectable to such a portion of frame body 470.

[0094] As previously discussed, the hub 460 may include a catheter hub retainer 474. Also, as previously discussed, the catheter hub retainer 474 may be configured to secure to the catheter hub 442. FIGS. 4LL-4MM show a perspective view of the catheter hub retainer 474 alone, and FIG. 4NN shows a front view of the catheter hub retainer 474 alone, while FIGS. 4Y-4II show the catheter hub retainer 474 connected to the clamp 466. The catheter hub retainer 474 may be configured to secure to the catheter hub 442. For example, the catheter hub retainer 474 may include a body 474a configured to secure to the catheter hub 442. In some implementations, the body 474a comprises a C-shape. In some implementations, the body 474a is configured to surround at least about 25%, at least about 50%, or at least about 75% of the cross section of the catheter hub 442. In some implementations, the body 474a is shaped to secure around a portion of the cylindrical cross section of the catheter hub 442. In some implementations, the body 474a is shaped to surround less than the entire perimeter of a cross-section of the catheter hub 442 (e.g., a circular cross-section of the catheter hub 442). In some implementations, the body 474a is configured to prevent relative movement between the body 474a and the catheter hub 442 when secured together. In some implementations, the body 474a is configured to prevent inadvertent disconnection between the catheter hub holder 474 and the catheter hub 442. The catheter hub holder 474 may additionally be coupled to the clamp 466. For example, the catheter hub holder 474 may be movably coupled (e.g., rotatably coupled) to the clamp 466. The catheter hub holder 474 may be movably coupled (e.g., rotatably coupled) to the frame 464 and / or membrane 462 via the clamp 466. The catheter hub holder 474 may be coupled to the frame 464 and / or membrane 462 via a gimbal configuration (e.g., via the clamp 466).Catheter hub retainer 474 may be rotatably coupled to frame 464 and / or membrane 462 (e.g., via clamp 466) such that catheter hub retainer 474 may at least partially rotate about one or more of three orthogonal axes (e.g., at least one, at least two, or all three of such axes). In some implementations, catheter hub retainer 474 includes ball 474c. Ball 474c may be secured within a cavity in clamp 466. For example, clamp 466 may include cavity 466c (see FIGS. 4OO-4RR) sized and / or shaped to receive ball 474c. FIGS. 4SS-4TT show axes 401, 403, and 405 that are perpendicular to one another. Referring to FIGS. 4SS-4TT and 4AA, width W2 of hub 460 extends along axis 405, and length L2 of hub 460 extends along axis 403. The height of the hub 460 (and / or the catheter stabilization device 400) extends along the axis 401. The cavity 466c can be configured to allow the ball 474c to at least partially rotate about one or more of the axes 401, 403, and / or 405. The ball 474c can have a spherical shape. In some implementations, the ball 474c and / or surfaces defining the cavity 466c comprise smooth surfaces to facilitate rotation of the ball 474c within the cavity 466c. In some implementations, the catheter hub retainer 474 includes a shaft 474b positioned between the body 474a and the ball 474c (see FIGS. 4LL-4N). In some implementations, the body 474a includes a flat portion to which the shaft 474b connects (which can be connected to two curved legs of the body 474a).

[0095] 4LL-4NN, in some implementations, the catheter hub retainer 474 includes one or more protrusions 474d (which may also be referred to as "ears") extending (e.g., radially outward) from the ball 474c. In some implementations, the catheter hub retainer 474 includes both protrusions 474d. Referring to FIGS. 4QQ-4RR, the clamp 466 may include one or more slots 466d configured to receive the protrusions 474d. FIG. 4SS shows a cross section taken through a portion of the hub 460, as indicated in FIG. 4AA. The protrusions 474d can advantageously limit the amount of rotation of the catheter hub retainer 474 relative to the clamp 466 (as well as the frame 464 and / or membrane 462). Thus, protrusion 474d can limit the degree of rotation of catheter hub 442 when secured to catheter hub retainer 474, which can advantageously facilitate proper positioning and / or alignment of catheter hub 442 and catheter 441 when inserted at the catheter insertion site. Referring to at least Figures 4SS and 4TT, protrusion 474d can limit the amount of rotation of ball 474c, catheter hub retainer 474, and connected catheter hub 442 about each of axes 401, 403, and 405. In some implementations, the protrusions 474d can limit the rotation of the ball 474c, the catheter hub holder 474, and / or the connected catheter hub 442 relative to any or all of the shafts 401, 403, and 405 to an amount that is between about 0 degrees and about 60 degrees, between about 0 degrees and about 55 degrees, between about 0 degrees and about 50 degrees, between about 0 degrees and about 45 degrees, between about 0 degrees and about 40 degrees, between about 0 degrees and about 35 degrees, between about 0 degrees and about 30 degrees, between about 0 degrees and about 25 degrees, between about 0 degrees and about 20 degrees, between about 0 degrees and about 15 degrees, between about 0 degrees and about 10 degrees, or between about 0 degrees and about 5 degrees. In some variations, the catheter hub holder 474 does not include the protrusions 474d.

[0096] In some implementations, clamp 466 includes one or more features to limit the amount of rotation of ball 474c, catheter hub holder 474, and / or connected catheter hub 442 about any or all of axes 401, 403, and 405. For example, with reference to Figures 4QQ-4RR, clamp 466 may include one or more protrusions 466e, 466f extending from a surface of clamp 466, such as a surface proximate cavity 466c. With reference to Figure 4SS, protrusions 466e, 466f can contact body 474a of catheter hub holder 474 when catheter hub holder 474 is rotated a certain amount, thereby limiting the rotation of catheter hub holder 474 relative to axis 403. For example, protrusions 466e, 466f can be configured (e.g., sized and / or shaped) to limit (by contacting body 474a) rotation of catheter hub retainer 474 about axis 403 to any of the values ​​or ranges previously mentioned in connection with protrusion 474d. In some implementations, protrusion 466e has a length greater than protrusion 466f. This can advantageously maintain the tilt angle of body 474a relative to the subject's skin within a particular range, etc. Protrusions 466e, 466f can have a cylindrical cross-section or a different cross-section. In some variations, clamp 466 does not include protrusion 466e and / or does not include protrusion 466f.

[0097] 4LL-4NN, in some implementations, the catheter hub retainer 474 includes one or both arms 474e extending outward from the end of the body 474a. Such arms 474e may have a curved shape. The arms 474e may extend from the ends of curved legs of the body 474a. The arms 474e may extend in opposite directions from each other. The arms 474e can advantageously facilitate positioning and / or alignment of the catheter hub 442 relative to the body 474a during securement. For example, when clamp 466 is pivoted from an open position (such as the position shown in FIG. 4II) to a closed position (such as the position shown in FIG. 4HH) on catheter hub 442, one or both of arms 474e can contact catheter hub 442, push catheter hub 442, and / or align catheter hub 442 with body 474a so that catheter hub 442 is engaged by and positioned within body 474a.

[0098] FIGS. 5A-5H show another implementation of catheter stabilization device 500, or portions thereof. Catheter stabilization device 500 may be similar or identical in some or many respects to catheter stabilization device 400. FIGS. 5A and 5B show top perspective and top views, respectively, of catheter stabilization device 500. FIG. 5C shows a cross-sectional view taken through device 500 in an example use configuration. Although not shown in FIG. 5C, it is understood that catheter 441 may be at least partially positioned within a subject's blood vessel when in use. Catheter stabilization device 500 may include a cover 520, a hub 560, and an extension set 540. Hub 560 may be similar to or identical to hub 460. FIGS. 5D-5E show perspective views of cover 520. Cover 520 may be identical to cover 420, except with respect to connector 531. Connector 531 is exposed and includes a threaded end configured to secure to the threads of connector 546. 5G shows extension set 540, which may include connector 543, tube 549, tube 547, connector 548, connector 546, fitting 545, and gasket 541. Connector 543 may be similar to or identical to connector 443, connector 548 may be similar to or identical to connector 448, tubes 547 and 549 may be similar to or identical to tubes 447 and 449, and connector 546 may be similar to or identical to connector 446. Although FIGS. 5G-5H show connector 543 attached to tube 549, tube 549 may be a separate component from connector 543 and may be later joined to a portion of connector 543.

[0099] Connector 545 can fluidly couple tubes 547, 549 together. Connector 545 can include end 545a, which can be tapered (e.g., barbed). End 545a can be secured within the ends of tubes 547, 549. Connector 545 can include one or more (e.g., multiple) features configured to mate with corresponding features in an opening extending through cover 520 (e.g., connector 531) and inhibit (e.g., prevent) rotation of connector 545 relative to cover 520. For example, connector 545 can include one or multiple ribs 545b sized and shaped to match the size and shape of one or multiple grooves 531a extending in connector 531. Such ribs 545b can be similar to or identical to ribs 445a discussed above.

[0100] Figure 5D shows an enlarged view of a portion of what is shown in Figure 5C. Figure 5D shows extension set 540 (which may also be referred to as a "fluid conduit assembly") connected to cover 520 via a connection between connector 546 and the threaded end of connector 531. In some implementations, extension set 540 includes gasket 541 configured to engage tube 547 and inhibit (e.g., prevent) longitudinal movement of tube 547 (and, by extension, extension set 540) when connector 546 secures to connector 531, for example, in a manner similar to that described above with respect to gasket 149 of extension set 140.

[0101] FIGS. 6A-6G show another implementation of a catheter stabilization device 500′, or a portion thereof. The catheter stabilization device 500′ is identical to the catheter stabilization device 500, except with respect to the extension set 540′. The catheter stabilization device 500′ may include a cover 520 and a hub 560. FIGS. 6A-6B show top perspective and top views of the device 500′. FIG. 6C shows a cross-sectional view taken through the device 500′ in an example use configuration. Although not shown in FIG. 6C, it is understood that the catheter 441 may be at least partially positioned within a subject's blood vessel when in use. FIGS. 6D-6F show the extension set 540′, which may include a connector 543, a tube 549, a tube 547, a connector 548, a connector 546, a fitting 545′, and a gasket 541. The fitting 545′ may fluidly couple the tubes 547 and 549 together. Fitting 545′ may include a first end 545a′ that may be tapered and configured to be secured within the end of tube 549, and a second end 545c′ that has a cavity configured to receive the end of tube 547. Fitting 545′ may be permanently secured to tubes 549, 547. Fitting 545′ may include one or more (e.g., multiple) features that are configured to mate with corresponding features in an opening extending through cover 520, such as connector 531, and that inhibit (e.g., prevent) rotation of fitting 545′ relative to cover 520. For example, fitting 545′ may include one or multiple ribs 545b′ that are similar to or identical to ribs 445a and / or 545a.

[0102] Figure 6G shows an enlarged view of a portion of what is shown in Figure 6C. Figure 6G shows extension set 540' connected to cover 520 via a connection between connector 546 and the threaded end of connector 531. In some implementations, extension set 540' includes gasket 541 configured to engage tube 547 and inhibit (e.g., prevent) longitudinal movement of tube 547 (and thus extension set 540') when connector 546 secures to connector 531, for example, in a manner similar to that described above with respect to gasket 149 of extension set 140.

[0103] 7A-7U show another implementation of a hub 460′ that can be utilized with a cover 420 and extension set 440 in a manner similar to that shown and / or described herein with respect to the hub 460. The hub 460′ (which may also be referred to as a “dock” or “base”) can also be utilized with either a cover 520 and extension set 540, 540′. FIGS. 7A-7B show a top perspective view of the hub 460′ with a catheter hub 442 secured thereto, while FIGS. 7C-7D show the same views as FIGS. 7A-7B but without the catheter hub 442 attached. FIGS. 7E-7F show top and bottom views (respectively). FIGS. 7G-7H show side views of the hub 460′. FIGS. 7I-7J show front and rear views (respectively) of the hub 460′. The hub 460′ can include a membrane 462′, which can be similar or identical to the membrane 462. For example, membrane 462' may have an opening 463' that may be similar to or identical to opening 463 in membrane 462. Hub 460' may also include a frame 464' that may be similar in some or many respects to frame 464. For example, frame 464' may have a frame body 470' that is annular in shape and may have fingers 475' that may be similar to or identical to fingers 475. Hub 460' may include latch arm 473a' that may be similar to or identical to latch arm 473. Hub 460' may include protrusion 473b' that may be similar to or identical to protrusion 473b of hub 460. Hub 460' may also include clamp 466' (which may also be referred to as a "clasp" or a "boom") and catheter hub retainer 474'. Catheter hub retainer 474' may be similar to or identical to catheter hub retainer 474. Referring to FIG. 7M, the frame 464′ may include one or multiple grooves 499′ in the frame body 470′, which may facilitate bonding of the membrane 462′ and may be similar or identical to the grooves 499.

[0104] The frame 464′, membrane 462′, and / or clamp 466′ (which may be connected to one another) may be configured to secure (e.g., removably secure) to the subject's skin (e.g., via membrane 462′). The catheter hub holder 474′ may be configured to secure to the catheter hub 442. As described in more detail below, the catheter hub holder 474′ may be movably coupled (e.g., rotatably coupled) to the membrane 462′ and / or frame 464′ via clamp 466′ in a manner similar or identical to that described above with respect to the catheter hub holder 474 and clamp 466. The clamp 466′ may be connected to one or more portions of the frame 464′. For example, if the frame 464′ has an annularly shaped frame body 470′, the clamp 466′ may be connected to both sides of the frame body 470′, as shown. In an implementation of the catheter stabilization device 400 having a frame 464′ and a membrane 462′, where the membrane 462′ includes an opening 463′, the clamp 466′ can extend across and / or across the opening 463′ between two portions of the frame body 470′.

[0105] 7R-7T show top perspective views of clamp 466', and FIG. 7U shows a bottom perspective view of clamp 466'. Clamp 466' may include a latch portion 466b' that is similar to or identical to latch portion 466b of clamp 466. Latch portion 466b' may be disposed at a first end of clamp 466'. Latch portion 466b' may include one or more nub 469b', 469c' and ledge 469a', each of which may be similar to or identical to nub 469b, 469c and ledge 469a of clamp 466. Latch portion 466b' may be removably securable to a portion of frame 464'. 7Q (showing an enlarged view of a portion of frame 464′), frame 464′ can include protrusions 467a′, 467b′, 467c′, 467d′, which can be similar to or identical to protrusions 467a, 467b, 467c, 467d. Nests 469b′, 469c′ and ledge 469a′ can interact with protrusions 467a′, 467b′, 467c′, 467d′ in a manner similar to or identical to that described above in connection with nests 469b, 469c, ledge 469a, and protrusions 467a, 467b, 467c, 467d.

[0106] Clamp 466' can be pivotally connected to frame 464' and can be configured to pivot between multiple positions in a manner similar or identical to that described above with respect to clamp 466. Figures 7K-7M show frame 464', frame body 470', clamp 466', and catheter hub retainer 474' without membrane 462'. Figures 7N-7J show side and bottom perspective views of clamp 466' and catheter hub retainer 474' without frame 464' and membrane 462'. Figures 7K-7L (and Figures 7A-7J) show clamp 466' in a first position (an example of a closed position), and Figures 7M-7O show clamp 466' in a second position (an example of an open position). The pivoting movement of clamp 466′ can advantageously facilitate securement of catheter hub 442 within catheter hub holder 474′ in a manner similar or identical to that described above in connection with clamp 466′ and catheter hub holder 474. Clamp 466′ can include one or more biological hinges configured to allow clamp 466′ to pivot relative to frame 464′ (and membrane 462′). For example, clamp 466′ can include one or more biological hinges. With reference to FIGS. 7R-7U, clamp 466′ can include a first biological hinge 491′ having a first hinge portion 491 a′, a second hinge portion 491 b′, and a third hinge portion 491 c′ connecting first hinge portion 491 a′ and second hinge portion 491 b′ to each other. The clamp 466' may include a second biological hinge 493' having a first hinge portion 493a', a second hinge portion 493b', and a third hinge portion 493c' connecting the first hinge portion 493a' and the second hinge portion 493b' to each other.

[0107] The clamp 466′ can be pivotally secured to the frame 464′. For example, in some implementations, the clamp 466′ includes one or more posts 495a′, 495b′ configured to secure (e.g., via a press fit) within an opening in a portion of the frame 464. For example, the posts 495a′, 495b′ can be secured within a hole 465a′ extending through a lip 465′ extending (e.g., inwardly) from the frame body 470′ (see FIG. 7F). In some implementations, such as those shown in the figures, the posts 495a′, 495b′ extend from the second hinge portions 491b′, 493b′. The clamp 466' can be secured to the frame 464' via securing the posts 495a', 495b' within the openings 465a' in the frame 464', and the clamp 466' can be configured to pivot between a number of positions, including, but not limited to, the open and closed positions shown in the figures.

[0108] In some implementations, the clamp 466′ includes a biasing member configured to bias the clamp 466′ toward a closed position (e.g., a position in which the latch portion 466b′ is closer to the frame 464′ / frame body 470′). For example, the clamp 466′ may include a biasing member 497′. The biasing member 497′ may be positioned proximate the biological hinges 491′, 493′, for example, at an end of the clamp 466′. The biasing member 497′ may act to urge the clamp 466′ from a first position in which the first and second hinge portions 491 a′ and 491 b′ are spaced apart from one another to a second position in which the first and second hinge portions 491 a′ and 491 b′ are close together and / or in contact with one another. Additionally, first hinge portion 491 a' and second hinge portion 493 b' can be spaced apart from one another when clamp 466' is in such a first position and can be close together and / or contact one another when clamp 466' is in such a second position. Clamp 466' can be secured to frame 464' in alternative manners other than via securing posts 495 a', 495 b' within openings 465 a'. In some variations, clamp 466' can be permanently secured to frame 464'.

[0109] With continued reference to FIGS. 7R-7U, clamp 466′ may include a cavity 466c′ and a slot 466d′ that may be similar or identical to cavity 466c and slot 466d (respectively) of clamp 466.

[0110] 8A-8J illustrate another implementation of hub 460" that can be utilized with cover 420 and extension set 440 in a manner similar to that shown and / or described herein with respect to hub 460. Hub 460" (which may also be referred to as a "dock" or "base") can also be utilized with cover 520 and any of extension sets 540, 540'. Hub 460" can be similar to hub 460 in some or many respects. For example, hub 460" can include membrane 462" that can be similar to or identical to membrane 462. Hub 460" can include frame 464" and frame body 470" that can be similar to frame 464 and frame body 470 in many respects. The hub 460" may include an opening 463", a latch arm 473a", a protrusion 473b", and a support portion 475", each of which may be similar or identical to the opening 463, the latch arm 473a, the protrusion 473b, and the support portion 475 of the hub 460. The hub 460" may include a clamp 466" and a catheter hub retainer 474". Figures 8A-8B show a top perspective view of the hub 460". Figure 8C shows a perspective view of the frame 464" separated from the clamp 466" and the catheter hub retainer 474" (membrane 462" not shown). Figure 8D shows an enlarged view of a portion of the frame 464". Figures 8E-8F show a perspective view of the catheter hub retainer 474". Figures 8G-8J show top and bottom perspective views of the clamp 466".

[0111] Referring to FIG. 8C, frame 464″ can include one or multiple grooves 499″ in frame body 470″, which can facilitate attachment of membrane 462″ and can be similar or identical to groove 499. As also shown, frame 464″ can include one or both hooks 465a″ and / or protrusions 465b″, which can be configured to receive pin 466a″ (see FIGS. 8G-8J) of clamp 466″ in a manner similar to or identical to that described above with respect to pin 466a, hook 465a, and protrusion 465b. Clamp 466″ can be configured to pivot relative to frame 464″ in a manner similar to or identical to that described above with respect to clamp 466 and frame 464.

[0112] 8G-8J, clamp 466" can include pin 466a" (e.g., at a first end of clamp 466") and latch portion 466b" (e.g., at a second end of clamp 466"). Latch portion 466b" can be configured to engage a portion of frame 464" in a manner similar to that described above with respect to latch portion 466b and frame 464. Latch portion 466b" can include a ledge 469a" that can be configured to interact with (e.g., secure to) a protrusion 467a" extending from frame body 470" (see FIG. 8D) in a manner similar to that described above with respect to ledge 469a and protrusion 467a. Protrusion 467a" can be tapered and / or can inhibit disconnection of latch portion 466b" from frame 464" in a manner similar or identical to that described in connection with latch portion 466b and frame 464. Latch portion 466b" can include one or both of nubbins 469b", 469c" that can be configured to interact with and / or be positioned between protrusions 467c", 467d" extending from frame body 470". Protrusions 467c", 467d" (which may also be referred to as "guiding protrusions" or "alignment protrusions") can be spaced apart from one another and act as guides to assist in positioning latch portion 466b". Protrusions 467c", 467d" may have tapered ends (see FIG. 8D) that can contact nub 469b", 469c" when latch portion 466b" is moved to a closed position (such as the position shown in FIGS. 8A-8B) and assist in positioning and / or aligning protrusion 467a" with ledge 469a". With reference to FIGS. 8A and 8C, nub 469b", 469c" may be configured to bear against frame body 470" when clamp 466" is in a closed position, such as the position shown in FIGS. 8A-8B. With reference to FIGS. 4OO and 8H, latch portion 466b" of clamp 466" may have a smaller width than latch portion 466b of clamp 466.4KK and 8D, the distance between protrusions 467b" and 467d" is less than the distance between protrusions 467c and 467d, which are sized to receive latches 466b" and 466b (respectively). The shorter width of latch portion 466b" and the shorter distance between protrusions 467c" and 467d" can provide more space for male connector 443 when connected (either alone or with extension set 440), for example.

[0113] 8E-8F show perspective views of catheter hub holder 474". Catheter hub holder 474" may be similar or identical in some or many respects to catheter hub holder 474. Catheter hub holder 474" may include body 474a", ball 474c", shaft 474b", ears 474d", and / or arms 474e", each of which may be similar or identical to body 474a, ball 474c, shaft 474b, and arms 474e (respectively) described above.

[0114] 8G-8J, the clamp 466" may include a cavity 466c" that may be configured to receive the ball 474c" of the catheter hub retainer 474". The cavity 466c" may be similar to or identical to the cavity 466c of the clamp 466. The clamp 466" may also include one or both slots 466d" that may be configured to receive the ear 474d" of the catheter hub retainer 474" in a manner similar to or identical to that described above with respect to the slot 466d and the ear 474d. The ear 474d" may be positionable within the slot 466d" and may be configured to limit rotation of the ball 474c" in a manner similar to or identical to that described above with respect to the ear 474d and the slot 466d. In some variations, the catheter hub retainer 474" does not include the ear 474d". As shown, clamp 466'' may include a ridge 466g'' extending from pin 466a'', which may be similar or identical to ridge 466g.

[0115] In addition to, or as an alternative to, ears 474d" and slots 466d", catheter hub holder 474" and clamp 466" can include other structure that can limit rotation of catheter hub holder 474" relative to clamp 466". Limiting rotation of catheter hub holder 474" relative to clamp 466" can further limit rotation of catheter hub 442 relative to clamp 466", frame 464", and / or membrane 462" when catheter hub 442 is connected to catheter hub holder 474". Referring to Figures 8E-8F and 81-8J, catheter hub holder 474" can include protrusion 474f" that can be configured to engage stop 466e" of clamp 466" to limit rotation of catheter hub holder 474" relative to clamp 466". In addition to or as an alternative to stop 466e", clamp 466" can include protrusion 466f". In some implementations, protrusion 466f" has a tapered shape. Stop 466e" and protrusion 466f" can limit movement of catheter hub holder 474" relative to clamp 466" in a manner similar to that described above with respect to protrusions 466e, 466f. In some variations, catheter hub holder 474" does not include protrusion 474f". In some variations, clamp 466" does not include stop 466e" and / or does not include protrusion 466f".

[0116] Additional Considerations While the present disclosure has been described in the context of specific examples, it will be understood by those skilled in the art that the present disclosure extends beyond the specifically disclosed examples to other alternative examples and / or uses of the disclosure, as well as obvious modifications and equivalents thereof. Also, while several variations of the present disclosure have been shown and described in detail, other modifications that are within the scope of the present disclosure will be readily apparent to those skilled in the art based on this disclosure. It is also contemplated that various combinations or subcombinations of specific features and aspects of the examples can be made and still fall within the scope of the present disclosure. Accordingly, it should be understood that various features and aspects of the present disclosure can be combined with or substituted for one another to form various aspects of the disclosed examples.

[0117] Certain features that are described in this disclosure in the context of separate implementations may also be implemented in combination in a single implementation. Conversely, various features that are described in the context of a single implementation may also be implemented separately in multiple implementations or in any suitable subcombination. Furthermore, while features may be described above as acting in a particular combination, one or more features from a claimed combination may in some cases be deleted from the combination, and the combination may be claimed as a subcombination or as a variation of the subcombination.

[0118] In particular, conditional phrases such as "can," "could," "could," or "may," unless expressly stated otherwise or understood within the context in which they are used, are generally intended to convey that certain embodiments include, but other embodiments do not include, particular features, elements, and / or steps. Thus, such conditional phrases are generally not intended to imply that features, elements, and / or steps are in any way required for one or more embodiments.

[0119] Certain terminology may be used in the following description for purposes of reference only and therefore is not intended to be limiting. For example, terms such as "above" and "below" refer to directions in the drawings to which reference is made. Terms such as "proximal," "distal," "anterior," "dorsal," "posterior," and "lateral" describe the orientation and / or location of a component or portion of an element within a consistent but arbitrary frame of reference that is made clear by reference to the characters describing the component or element being discussed and the associated drawings. Such terms may include explicitly previously mentioned words, derivatives thereof, and words of similar import.

[0120] Transitional language such as the phrase "at least one of X, Y, or Z," unless expressly stated otherwise, is understood with context as generally used to convey that an item, term, etc. can be either X, Y, or Z. Thus, such transitional language is generally not intended to imply that a particular embodiment requires the presence of at least one X, at least one Y, and at least one Z.

[0121] As used herein, degree language, such as the terms "approximately," "about," "generally," and "substantially," refers to a value, amount, or characteristic that is close to the stated value, amount, or characteristic yet still performs a desired function or achieves a desired result. For example, the terms "approximately," "about," "generally," and "substantially" can refer to an amount that is within less than 10%, less than 5%, less than 1%, less than 0.1%, and less than 0.01% of the stated amount. As another example, in certain implementations, the terms "generally parallel" and "substantially parallel" refer to a value, amount, or characteristic that deviates from exact parallelism by no more than 10 degrees, no more than 5 degrees, no more than 3 degrees, or no more than 1 degree. As another example, in certain implementations, the terms "generally perpendicular" and "substantially perpendicular" refer to a value, amount, or characteristic that deviates from exact perpendicular by no more than 10 degrees, no more than 5 degrees, no more than 3 degrees, or no more than 1 degree.

[0122] While the above detailed description illustrates, describes, and points out novel features, it will be understood that various omissions, substitutions, and changes in the form and details of the illustrated devices or systems can be made without departing from the spirit of the disclosure. As will be recognized, certain portions of the description herein may be embodied in forms that do not provide all of the features and benefits set forth herein, since some features may be used or practiced separately from others. The scope of the specific embodiments disclosed herein is dictated by the appended claims, rather than by the foregoing description. All changes that come within the meaning and range of equivalency of the claims are intended to be embraced within their scope. [Explanation of symbols]

[0123] 100 Catheter stabilization device 101, 103, 105 Reference axis 120 Cover 122 Wings 122a aperture 123a Upper part 123b wall 131 Connector 131a Connector body 131b Threaded part 133 Aperture Ports 137a and 137b 137c, 137d aperture 139a, 139b protrusions 140 Extension Set 141 Catheter 142 Catheter Hub 143 Connector 145 Stop part 146 Connector 147 tube 148 Connectors 149 Gasket 160 Hub 162 Membrane 162a perforation 163 Aperture 164, 164´ Frame 166, 166´ Receiving part 66d distance 1 166i, 166i´ inside 170, 170´ frame body 173a, 173b Latch arm 174, 174´, 174´´, 174´´´ Catheter hub holder 174a, 174a´, 174a´´, 174b´, 174a´´´ main body 174b, 174b´, 174b´´ Arm 174d distance 174h Height of arm 174b 174w Arm width 174b 175 Finger section 197 Hook 199 Cutout 199a Wall 199b Groove 199c curved part 200 Electronic Devices 200a upper shell 200b lower shell 201 Electrical Components 202 Processing equipment 204 Camera 206 Light source 208 Sensors 210 Communication Module 212 Batteries 220 pins 222 Camera 224 UV LED 226 Broad and / or Narrow Spectrum LEDs 228 Circuit Board 320 Cover 322 Wings 323a upper part 323b Wall 331 Connector 331a connector body 331b screw part 391a Cavity 391b Groove 399 Aperture 400 Catheter Stabilization Device 401, 403, 405 Reference axis 420 Cover 422 Wings 422b Protrusion 423a upper part 423b Wall 431 Connector 433 Aperture Ports 437a and 437b 439a protrusion 440 Extension Set 441 Catheter 442 Catheter Hub 443 Connector 445 Fluid Pipe Connector 445a Rib 445b thread 445c First internal part 445d Interior wall 445e Second internal part 445f Periphery 445g Sealing material 446 Connector 447 Second Fluid Pipe 448 Connector 449 First Fluid Pipe 460, 460´, 460´´ Hub 462, 462´, 462´´ membrane 462a perforation 463, 463´, 463´´ opening 464, 464´, 464´´ Frame 465´ Lips 465a, 465a´´ hook 465a´ hole, opening 465b, 465b´´ Protrusion 466, 466´, 466´´ Clamp 466a, 466a´´ pin 466b, 466b´, 466b´´ Latch part 466c, 466c´, 466c´´ hollow 466d, 466d´, 466d´´ Slot 466e protrusion 466e´´ Stop part 466f, 466f´´ protrusion 466g, raised 466g´´ raised 467a, 467a´, 467a´´, 467b, 467b´, 467c, 467c´, 467c´´, 467d, 467d´, 467d´´ Protrusion 469a, 469a´, 469a´´ Shelf 469b, 469b´, 469b´´, 469c, 469c´, 469c´´ Small bump 470, 470´, 470´´ frame body 473a, 473a´, 473a´´ Latch arm 473b, 473b´, 473b´´ Protrusion 474, 474´, 474´´ Catheter hub holder 474a, 474a´´ main body 474b, 474b´´ Shaft material 474c, 474c´´ ball 474d, 474d´´ projection, ear 474e, 474e´´ Arm 474f´´ Protrusion 475, 475´, 475´´ Finger section, indicator section 491´ First Biological Hinge 491a´ First hinge part 491b´ Second hinge part 491c´ Third hinge part 493´ Second biological hinge 493a´ First hinge part 493b´ Second hinge part 493c´ Third hinge part Columns 495a´ and 495b´ 497 Lips 497´ Biasing member 497a aperture 499, 499´, 499´´ Groove 500, 500´ Catheter Stabilization Device 520 Cover 531a Groove 540, 540´ Extension Set 541 Gasket 543 Connector 545, 545´ Mounting Bracket 545a end 545a´ First end 545b, 545b´ Rib 545c´ Second end 546 Connector 547 tube 548 Connector 549 tube 560 Hub 574´ Catheter Hub Retainer W1 hub 160 width W2 hub 460 width L1 hub 160 length L2 hub 460 length

Claims

1. 1. A device configured for use at a catheter insertion site in a subject, comprising: a base including an opening, the base configured to be secured to the subject's skin such that the opening is positioned over the catheter insertion site; a catheter hub holder configured to secure to a catheter hub connected to a catheter configured for insertion at the catheter insertion site; Equipped with The catheter hub retainer is movably coupled to the base to allow relative movement between the base, the catheter hub, and the catheter when the catheter is inserted at the catheter insertion site.

2. The device of claim 1 , wherein the catheter hub retainer is movably coupled to the base via a gimbal arrangement.

3. 3. The device of claim 1 or 2, wherein the catheter hub holder is rotatably coupled to the base and configured to rotate at least partially about three mutually orthogonal axes.

4. The device of claim 3 , wherein the catheter hub retainer comprises a ball, the base comprises a cavity configured to receive the ball, and the ball is rotatable within the cavity.

5. The catheter hub holder includes: a body configured to surround and secure to a portion of the catheter hub; a shaft connected to the body and the ball and extending between the body and the ball so that the ball is spaced from the body; The device of claim 4 further comprising:

6. The device of claim 5 , wherein the body is configured to hold the catheter hub above the subject's skin when the device is in use.

7. 7. The device of claim 1, wherein the base further comprises a membrane configured to be secured to the skin of the subject, and a frame connected to the membrane, the frame being more rigid than the membrane, and the catheter hub holder being movably coupled to the frame.

8. 8. The device of claim 7, wherein the base further comprises a clamp connected to the frame, the clamp comprising the cavity of the base, and the catheter hub retainer is movably coupled to the frame via the clamp.

9. 9. The device of claim 8, wherein at least one of the catheter hub holder and the clamp is configured such that rotation of the catheter hub holder relative to the clamp is limited about at least one of the three mutually orthogonal axes.

10. the clamp includes at least one slot; the catheter hub retainer further comprises at least one ear extending outwardly from the ball and positioned within the at least one slot of the clamp; 10. The device of claim 9, wherein contact between a portion of the clamp forming the at least one slot and the at least one ear limits the amount of rotation of the catheter hub retainer relative to the clamp about at least one of the three mutually orthogonal axes.

11. the membrane includes the opening in the base; the frame is connected to the membrane along a periphery of the opening; the clamp has a first end and a second end, the first end pivotally connected to a first portion of the frame such that the clamp is pivotable between a closed position and an open position; In the closed position, the second end of the clamp is connected to a second portion of the frame; 11. The device of claim 8, wherein in the open position, the second end of the clamp is not connected to the second portion of the frame.

12. The device of claim 11 , wherein the clamp comprises a pin at the first end, and the first portion of the frame is configured to pivotally secure the pin.

13. 13. The device of claim 11 or 12, wherein the clamp comprises one or more biological hinges at the first end configured to pivot the clamp between the open and closed positions.

14. 14. The device of claim 11, wherein the clamp further comprises a latch at the second end configured to removably connect to one or more protrusions disposed on the second portion of the frame.

15. 15. The device of claim 1, further comprising a cover configured to removably connect to the base and to surround the opening and the catheter insertion site.

Images