button-activated auto-injector

Abstract

The syringe includes a housing having proximal and distal ends extending along a longitudinal axis. The medication container contains a volume of medication. A button coupled to the housing is rotatable about the longitudinal axis between a locked position and an unlocked position and movable along the longitudinal axis between a pre-fired position and a fired position. A latch is at least partially disposed within the button, a ram is movable relative to the latch, and an energy source biases the ram distally along the longitudinal axis. The ram is prevented from moving relative to the latch by the button in the pre-fired position. Rotation of the button to the unlocked position and movement of the button distally along the longitudinal axis relative to the housing to the fired position allows the ram to move relative to the latch.

Description

[Technical Field]

[0001] button-activated auto-injector Technical Field The present disclosure relates generally to button-activated auto-injectors and, in some embodiments, to button-activated trigger devices for the delivery of large amounts of medication for subcutaneous surface penetration. Summary of the Invention [Means for solving the problem]

[0002] overview In certain embodiments, the syringe includes a housing having proximal and distal ends extending along a longitudinal axis, a medicament container containing a volume of medicament, a button coupled to the housing, the button rotatable about the longitudinal axis between a locked position and an unlocked position and movable along the longitudinal axis between a pre-fired position and a fired position, a latch at least partially disposed within the button, a ram movable relative to the latch, and an energy source configured to bias the ram distally along the longitudinal axis. In certain embodiments, the ram is prevented from moving relative to the latch by the button in the pre-fired position. In certain embodiments, rotation of the button to the unlocked position and movement of the button distally along the longitudinal axis relative to the housing to the fired position allows the ram to move relative to the latch.

[0003] In certain embodiments, the button includes a button body, a button opening extending through the button body, and a fin extending distally from a proximal end of the button body. In certain embodiments, the latch includes a latch body, a crown defined at the proximal end of the latch body configured to engage the fin of the button, and an engagement feature extending from the latch body, the engagement feature being movable between engaged and disengaged positions. In certain embodiments, at least a portion of the fin engages with the crown when the button is in the locked and unlocked positions.

[0004] In certain embodiments, the ram includes a ram body and a ram opening extending through the ram body, the ram opening configured to receive at least a portion of the engagement feature when the button is in the pre-fire position. In certain embodiments, the engagement feature comprises a flexible arm extending along the longitudinal axis and a protrusion extending radially therefrom. In certain embodiments, the protrusion extends radially inward from the end of the flexible arm. In certain embodiments, rotation of the button to the unlocked position aligns the button opening with the engagement feature. In certain embodiments, distal movement of the button to the fired position allows the engagement feature to flex radially outward and extend at least partially through the button opening.

[0005] In certain embodiments, the medication container includes a luer lock extending from a distal end thereof, and the syringe further includes a plunger disposed within the luer lock. In certain embodiments, the ram engages the plunger, thereby moving the plunger relative to the medication container when the button is moved to the fired position. In certain embodiments, movement of the plunger relative to the medication container expels a volume of medication from the medication container via the luer lock.

[0006] In certain embodiments, the syringe further comprises a needle coupled to the luer lock, the needle in fluid communication with the medication container. In certain embodiments, the syringe further comprises a luer cap removably coupled to the luer lock in the storage configuration, the luer cap being fully recessed within the housing. In certain embodiments, the button is prevented from moving proximally relative to the housing after the button is moved from the pre-fire position to the fired position. In certain embodiments, the volume of the medication is at least 10 mL. In certain embodiments, the latch is fixed relative to the housing, and the medication container is fixed relative to the housing.

[0007] In certain embodiments, a method of delivering a medicament to a subject using a syringe includes: a housing having proximal and distal ends extending along a longitudinal axis; a medicament container containing a volume of medicament; a button coupled to the housing, the button rotatable about the longitudinal axis between a locked position and an unlocked position and movable along the longitudinal axis between a pre-fired position and a fired position; a latch at least partially disposed within the button; a ram movable relative to the latch; and an energy source configured to distally bias the ram along the longitudinal axis, the method including: separating a luer cap from a luer lock of the medicament container with a luer cap remover, the luer cap being fully recessed within the housing; coupling a needle to the luer lock, the needle in fluid communication with the medicament container; rotating the button to the unlocked position; inserting at least a portion of the needle into the subject; moving the button distally relative to the housing to the fired position; releasing the volume of medicament into the subject through the needle; and removing the needle from the subject.

[0008] In certain embodiments, the ram is prevented from moving relative to the latch by the button in the pre-fired position, hi certain embodiments, rotation of the button to the unlocked position and movement of the button distally along the longitudinal axis relative to the housing to the fired position allows the ram to move relative to the latch.

[0009] In certain embodiments, the method may further include rotating the button to an unlocked position to align a button opening in the button with an engagement feature of the latch. In certain embodiments, the method may further include moving the button distally to a fired position, thereby allowing the engagement feature to flex radially outward and extend at least partially through the button opening.

[0010] In certain embodiments, the method may further include the ram engaging a plunger disposed within the medication device, thereby moving the plunger relative to the medication container when the button is moved to the fired position. In certain embodiments, the method may further include moving the plunger relative to the medication container expelling a volume of medication from the medication container through the needle. In certain embodiments, the method may further include the button being prevented from moving proximally relative to the housing after the button is moved to the fired position.

[0011] BRIEF DESCRIPTION OF THE DRAWINGS The foregoing summary, as well as the following detailed description of embodiments of a button-activated auto-injector, will be better understood when read in conjunction with the accompanying drawings of illustrative embodiments, it being understood, however, that the invention is not limited to the precise arrangements and instrumentalities shown. [Brief explanation of the drawings]

[0012] [Figure 1] FIG. 1 is a front view of a button-activated auto-injector according to an exemplary embodiment of the present invention. [Figure 2] FIG. 2 is a side view of the auto-injector of FIG. 1. [Figure 3] FIG. 2 is a front cross-sectional view of the auto-injector of FIG. 1. [Figure 4] FIG. 2 is a side cross-sectional view of the auto-injector of FIG. 1. [Figure 5] FIG. 2 is a front partial semi-transparent view of the auto-injector of FIG. 1. [Figure 6] FIG. 2 is a front partial semi-transparent view of the auto-injector of FIG. 1. [Figure 7] FIG. 2 is a partial cross-sectional front view of the auto-injector of FIG. 1 with the button in the pre-fire position. [Figure 8] 2 is a side cross-sectional partial view of the auto-injector of FIG. 1 with the button in the pre-fire position. [Figure 9] FIG. 2 is a partial cross-sectional front view of the auto-injector of FIG. 1 with the button in the firing position. [Figure 10] 2 is a side cross-sectional partial view of the auto-injector of FIG. 1 with the button in the fired position. [Figure 11] FIG. 2 is a front view of the button of the auto-injector of FIG. 1. [Figure 12] FIG. 2 is a bottom perspective cross-sectional view of the button of the auto-injector of FIG. 1. [Figure 13] FIG. 2 is a top perspective view of the latch of the auto-injector of FIG. 1. [Figure 14] 2 is a side cross-sectional view of the latch of the auto-injector of FIG. 1. [Figure 15] FIG. 2 is a bottom perspective view of the ram of the auto-injector of FIG. 1. [Figure 16] FIG. 2 is a side view of the ram of the auto-injector of FIG. 1. [Figure 17] 2 is a front view of a medication container of the automatic injector of FIG. 1 with a needle attached thereto. [Figure 18] 2 is a front cross-sectional view of a drug container of the auto-injector of FIG. 1 with a plunger disposed therein and a needle coupled thereto. [Figure 19] FIG. 2 is a front view of the front housing of the auto-injector of FIG. 1. [Figure 20] FIG. 2 is a side view of the front housing of the auto-injector of FIG. 1. [Figure 21] FIG. 2 is a front view of the luer cap remover of the auto-injector of FIG. 1. [Figure 22] FIG. 2 is a front view of the needle shield of the auto-injector of FIG. 1. [Figure 23A] FIG. 2 is a front view of a luer cap remover disposed at the distal end of the auto-injector of FIG. 1; [Figure 23B] FIG. 2 is a front view of the luer cap being removed from the auto-injector of FIG. 1. [Figure 24A] FIG. 2 is a front view of a needle and needle shield being installed in the auto-injector of FIG. 1. [Figure 24B] FIG. 2 is a front view of a needle attached to the auto-injector of FIG. 1. [Figure 24C] FIG. 2 is a front view of a needle and a needle shield being removed from the auto-injector of FIG. 1. DETAILED DESCRIPTION OF THE INVENTION

[0013] Detailed Description The present disclosure generally relates to an auto-injector, a button-activated trigger device used to deliver large volumes of injectable fluids, such as medications (e.g., doses of 10 mL or more) for subcutaneous surface penetration (e.g., subcutaneous and intramuscular injection). Devices that deliver large volumes of medication are often susceptible to configuration limitations as the volume of medication delivered increases, such as spring force limitations and syringe barrel breakage. Due to current configurations of the overall device design and limitations of biological uptake factors that limit injection rates and volumes, the injection device is often retained for long periods of time, leading to the use of other delivery methods, such as an internal delivery system that is attached to the patient during delivery.

[0014] An increasing number of biologics are being administered at home. However, with many biologics, the large doses and resulting large amounts of drug that must be delivered often hinder self-administration due to the length of time required to hold the delivery device in place. In certain instances, high concentrations of protein can be used to reduce injection volume, but the resulting drug often has a much higher viscosity than traditional biologics. High-power syringes can enable the delivery of these highly concentrated proteins. However, typical handheld syringe designs only allow for the injection of up to 2.5 mL of viscous drug within 30 seconds.

[0015] The development of enzymes that locally degrade hyaluronan (HA) in the subcutaneous (SC) space, thereby temporarily removing the barrier to fluid flow, could reduce the traditional limitations of biological uptake factors that limit injection rate and volume. Thus, larger volumes of viscous medications could be delivered. Therefore, there is a need to provide a handheld device capable of delivering high doses (e.g., 3 mL, 5 mL, 10 mL, 20 mL, and up to 50 mL) of viscous medications with delivery times suitable for a handheld device.

[0016] Drug delivery technologies for high-dose viscous medications are currently based on the proprietary recombinant human hyaluronidase PH20 enzyme (e.g., rHuPH20, Halozyme, Inc.), which facilitates SC delivery of co-administered therapeutics. rHuPH20 acts by degrading HA, which plays a role in resistance to bulk fluid flow in the SC space, limiting large amounts of SC drug delivery, dispersion, and absorption. Co-administration of rHuPH20 with injectable therapies has been shown to overcome the administration time and volume barriers associated with existing SC therapeutic formulations and reduce patient and healthcare provider burden compared to intravenous formulations. rHuPH20 has myriad applications in the current field of injectable therapies by increasing dispersion and absorption of other injectable drugs, such as anticancer therapies (e.g., trastuzumab and rituximab), immunodeficiency treatments, and infusions for rehydration in subcutaneous urography to improve resorption of radiopaque agents.

[0017] Referring in detail to the drawings, wherein like reference numerals refer to like elements throughout, FIGS. 1-24C show an auto-injector, generally designated 10, in accordance with an exemplary embodiment of the present invention.

[0018] As shown in FIGS. 1-4, the syringe 10 may include a housing 100, a drug container 102, a button 104, a latch 106, a ram 108, and an energy source 110. The housing 100 may have proximal and distal ends extending along a longitudinal axis L. The housing 100 may be configured to allow a user to grip or manipulate the syringe 10. The housing 100 may be shaped to fit a user's hand for one-handed function. The housing 100 may have a generally oval cross-section to aid in positioning the syringe 10 in the user's hand. The housing 100 may further include a ridge extending along the longitudinal axis L of the housing (as shown in FIG. 1) to aid in aligning or positioning the syringe 10 in the user's hand. The housing 100 may substantially accommodate the components shown in FIGS. 11-18.

[0019] The housing 100 may include a front housing 112 and a rear housing 114. The front housing 112 and the rear housing 114 may be joined together by a snap-fit ​​connection. In some embodiments, the front housing 112 and the rear housing 114 are joined using adhesive or other suitable means to prevent separation during use of the syringe 10. The rear housing 114 may have a generally oval cross-section with open proximal and distal ends. The proximal end of the rear housing 114 may have a generally circular opening sized and shaped to allow at least a portion of the button 104 to pass therethrough. The distal end of the rear housing 114 may have an opening sized and shaped to receive at least a portion of the front housing 112 therein. As shown in FIG. 19 , the front housing 112 may have a neck 120 extending from its proximal end. The neck 120 may include a neck protrusion 122 extending radially therefrom. The neck protrusion 122 may be received by a rear housing recess (not shown) when the neck 120 is disposed within the rear housing 114 .

[0020] As shown in FIG. 5, the rear housing 114 may include a status window 116 extending therethrough. The status window 116 may be generally oval-shaped and may be sized to display indicia for the buttons 104, as described in more detail below. The status window 116 may be located at the proximal end of the rear housing. While the status window 116 is shown on the front side of the rear housing 114 in FIG. 1, it should be understood that the status window 116 may be located on any side of the rear housing 114.

[0021] As shown in FIGS. 1 and 19 , the front housing 112 may be tapered and may include a medication window 118 extending therethrough. The medication window 118 may include a transparent film or may be empty. The medication window 118 allows a user to visually inspect the contents of the medication container 102 before, during, and after use of the syringe 10. In some embodiments, the medication window 118 may include one or more lines or symbols to identify the volume of medication within the medication container 102. The front housing 112 may include a lipped distal end 124, as shown in FIGS. 19-20 . The lipped distal end 124 may be shaped in various lengths to accommodate different sized needles to ensure proper injection depth.

[0022] In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 7 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 7.5 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 8 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 8.5 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 9 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 9.5 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 10 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 10.5 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 11 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 11.5 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 12 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 12.5 mm needle 132 to extend therethrough. In some embodiments, the flanged distal end 124 may be shaped and sized to allow an approximately 13 mm needle 132 to extend therethrough.

[0023] A drug container 102 containing a drug may be disposed within the housing 100. The drug container 102 may be fixed relative to the housing 100. As used herein, a drug may include a drug, biologic, solution, gel, suspension, or other substance that can be delivered via a syringe or needle, and such terms may be used interchangeably as they appear in the specification and claims. The drug container 102 may be a pre-filled syringe. In some embodiments, the drug container 102 may be an insertable drug cartridge. In some embodiments, the drug container 102 may be filled using a vial-and-needle or other suitable filling method. In one embodiment, the drug container 102 is one of a pre-filled cartridge, a pre-filled staked-needle syringe, a vial, or other injectable fluid-containing container. The drug container 102 has a distal portion and a proximal portion opposite the distal portion.

[0024] 17-18, the medicament container 102 may include a container portion 126 that defines a fluid chamber for containing the medicament. In one embodiment, the container portion 126 of the medicament container 102 has a maximum volume of approximately 10 mL. In one embodiment, the container portion 126 of the medication container 102 has a maximum volume selected from approximately 3 mL, 3.5 mL, 4 mL, 4.5 mL, 5.5 mL, 6 mL, 6.5 mL, 7 mL, 7.5 mL, 8 mL, 8.5 mL, 9 mL, 9.5 mL, 10 mL, 10.5 mL, 11 mL, 11.5 mL, 12 mL, 12.5 mL, 13 mL, 13.5 mL, 14 mL, 14.5 mL, 15 mL, 15.5 mL, 16 mL, 16.5 mL, 17 mL, 17.5 mL, 18 mL, 18.5 mL, 19 mL, 19.5 mL, 20 mL, 25 mL, 30 mL, 35 mL, 40 mL, 45 mL, and 50 mL.

[0025] As shown in Figures 3, 4, and 18, the medicament container 102 may further include a plunger 128 movable within the container portion 126 relative to the medicament container 102. Prior to use or triggering of the syringe 10, the plunger 128 may be disposed at the distal end of the container portion 126. The plunger 128 may seal the medicament in the container portion 126. The plunger 128 may be made of a rubber material. In one embodiment, the plunger 128 is made of plastic, butyl rubber, polyisoprene, polytetrafluoroethylene, high-density polyethylene, or other thermoset elastomer.

[0026] A flange 130 may extend outwardly from the distal portion of the drug container 102. In one embodiment, the flange 130 is a luer. In one embodiment, the flange 130 is a luer lock. As shown in FIGS. 3-4 , the flange 130 may include a luer cap 134 removably coupled thereto. The luer cap 134 may be coupled to the flange 130 in the storage configuration. The luer cap 134 may be completely disposed within the housing 100. In one embodiment, the luer cap 134 may be at least partially disposed within the housing 100.

[0027] In one embodiment, as shown in FIGS. 17-18 , flange 130 may be connectable to needle 132, which is in fluid communication with the medicament within reservoir portion 126. Needle 132 may include a connector 133 at its proximal end. Connector 133 may be a threaded member shaped and sized to mate with flange 130. In some embodiments, connector 133 includes deformable ribs that engage flange 130 to connect needle 132 to flange 130. Needle 132 may be a 25-gauge needle. In some embodiments, needle 132 may be a 15-gauge needle, a 16-gauge needle, a 17-gauge needle, an 18-gauge needle, a 19-gauge needle, a 20-gauge needle, a 21-gauge needle, a 22-gauge needle, a 23-gauge needle, a 24-gauge needle, a 25-gauge needle, a 26-gauge needle, a 27-gauge needle, a 28-gauge needle, a 29-gauge needle, a 30-gauge needle, a 31-gauge needle, a 32-gauge needle, a 33-gauge needle, a 34-gauge needle, or a 35-gauge needle.

[0028] In one embodiment, flange 130 may be connectable to a tubing set (not shown) that is in fluid communication with the medication in container portion 126. A needle 132 may be connected to flange 130 by a user, as described in more detail below. In one embodiment, a staked needle 27 may be pre-attached and extend from a distal portion of medication container 102.

[0029] Syringe 10 may be configured to deliver all or a portion of the medication in medication container 102. The medication contained in medication container 102 may have a volume of approximately 10 mL. In one embodiment, the medication contained in medication container 102 corresponds to a volume selected from the following: a) 3mL~5mL, 3mL~10mL, 3mL~15mL, 3mL~20mL, 3mL~25mL, 3mL~30mL, 3mL~35mL, 3mL~40mL, 3mL~45mL, 3mL~50mL, 5mL~10mL, 5mL~15mL, 5mL~20mL, 5mL ~25mL, 5mL~30mL, 5mL~35mL, 5mL~40mL;5mL~45mL, 5mL~50mL, 10mL~15mL;10mL~20mL;10mL~25mL;10mL~30mL;10mL~35mL;10mL~40mL, 10mL~50mL; b) About 3mL to about 5mL, about 3mL to about 10mL, about 3mL to about 15mL, about 3mL to about 20mL, about 3mL to about 25mL, about 3mL to about 30mL, about 3mL to about 35mL, approximately 3mL to approximately 40mL, approximately 3mL to approximately 45mL, approximately 3mL to approximately 50mL, approximately 5mL to approximately 10mL, approximately 5mL to approximately 15mL, approximately 5mL to approximately 20mL, approximately 5m L~25mL, approx.5mL~30mL, approx.5mL~35mL, approx.5mL~40mL; approx.5mL~45mL, approx.5mL~50mL, approx.10mL~15m L; about 10mL to about 20mL; about 10mL to about 25mL; about 10mL to about 30mL; about 10mL to about 35mL; about 10mL to about 40mL; about 10mL to about 50mL; c) at least about 3 mL, at least about 3.5 mL, at least about 4 mL, at least about 4.5 mL, at least about 5.5 mL, at least about 6 mL, at least about 6.5 mL, at least about 7 mL, at least about 7.5 mL, at least about 8 mL, at least about 8.5 mL, at least about 9 mL, at least about 9.5 mL, at least about 10 mL, at least about 10.5 mL, at least about 11 mL, at least about 11.5 mL, at least about 12 mL, at least about 12.5 mL, at least about 13 mL, at least at least about 13.5 mL, at least about 14 mL, at least about 14.5 mL, at least about 15 mL, at least about 15.5 mL, at least about 16 mL, at least about 16.5 mL, at least about 17 mL, at least about 17.5 mL, at least about 18 mL, at least about 18.5 mL, at least about 19 mL, at least about 19.5 mL, at least about 20 mL, at least about 25 mL, at least about 30 mL, at least about 35 mL, at least about 40 mL, at least about 45 mL, at least about 50 mL; and d) at least 3mL, at least 3.5mL, at least 4mL, at least 4.5mL, at least 5.5mL, at least 6mL, at least 6.5mL, at least 7mL, at least 7.5mL, at least 8mL, at least 8.5mL, at least 9mL, at least 9.5mL, at least 10mL, at least 10.5mL, at least 11mL, at least 11.5mL, at least 12mL, at least 12.5mL, at least 13mL, at least 13.5mL, at least 14mL, at least 14.5mL, at least 15mL, at least 15.5mL, at least 16mL, at least 16.5mL, at least 17mL, at least 17.5mL, at least 18mL, at least 18.5mL, at least 19mL, at least 19.5mL, at least 20mL, at least 25mL, at least 30mL, at least 35mL, at least 40mL, at least 45mL, at least 50mL.

[0030] The flow rate of the syringe 10 is highly dependent on the viscosity and volume of the medication. However, the syringe 10 may deliver the entire volume of medication at a rate of approximately 0.33 mL / sec. The syringe 10 may deliver 10 mL of medication at a rate of 0.33 mL / sec. In one embodiment, the syringe 10 delivers the entire deliverable volume of medication at the following rate: a) 0.5mL / 10 seconds, 0.75mL / 10 seconds, 1mL / 10 seconds, 1.25mL / 10 seconds, 1.5mL / 10 seconds, 1.75mL / 10 seconds, 2mL / 10 seconds, 2.25mL / 10 seconds, 2.5mL / 10 seconds, 2.7 5mL / 10 seconds, 3mL / 10 seconds, 3.25mL / 10 seconds, 3.5mL / 10 seconds, 3.75mL / 10 seconds, 4mL / 10 seconds, 4.25mL / 10 seconds, 4.5mL / 10 seconds, 4.75mL / 10 seconds, 5mL / 10 seconds; b)2mL / 30 seconds, 2.5mL / 30 seconds, 3mL / 30 seconds, 3.5mL / 30 seconds, 4mL / 30 seconds, 4.5mL / 30 seconds, 5mL / 30 seconds, 5.5mL / 30 seconds, 6mL / 30 seconds, 6. 5mL / 30 seconds, 7mL / 30 seconds, 7.5mL / 30 seconds, 8mL / 30 seconds, 8.5mL / 30 seconds, 9mL / 30 seconds, 9.5mL / 30 seconds, 10mL / 30 seconds, 10.5mL / 30 seconds; and c) 4mL / min, 5mL / min, 6mL / min, 7mL / min, 8mL / min, 9mL / min, 10mL / min, 11mL / min, 12mL / min, 13mL / min, 14mL / min, 15mL / min, 16mL / min, 17mL / min, 18mL / min, 19mL / min, 20mL / min, 21mL / min.

[0031] The viscosity of the drug may be 1-20 cP. In one embodiment, the drug may have the following viscosity: a) 1cP, 2cP, 3cP, 4cP, 5cP, 6cP, 7cP, 8cP, 9cP, 10cP, 11cP, 12cP, 13cP, 14cP, 15cP, 16cP, 17cP, 18cP, 19cP, 20cP; and b) Between 1 and 20 cP, between 2 and 19 cP, between 3 and 18 cP, between 4 and 17 cP, between 5 and 16 cP, between 6 and 15 cP, between 7 and 14 cP, between 8 and 13 cP, between 9 and 12 cP, between 10 and 11 cP.

[0032] In some embodiments, the user experience is improved if the injector 10 delivers the entire volume of medication as quickly as possible. Faster delivery may result in less pain and discomfort for the patient. The injector 10 may deliver the entire deliverable volume of medication in less than 5 seconds. In some embodiments, the injector 10 may deliver the entire deliverable volume of medication in less than 10 seconds, less than 15 seconds, less than 20 seconds, less than 25 seconds, less than 30 seconds, less than 35 seconds, less than 40 seconds, less than 45 seconds, less than 50 seconds, less than 55 seconds, less than 60 seconds, less than 70 seconds, less than 80 seconds, less than 90 seconds, less than 100 seconds, less than 110 seconds, or less than 120 seconds. In some embodiments, the syringe 10 may deliver the entire volume of medication between 5 and 120 seconds, between 10 and 110 seconds, between 15 and 100 seconds, between 20 and 90 seconds, between 25 and 80 seconds, between 30 and 70 seconds, between 35 and 60 seconds, between 40 and 55 seconds, or between 45 and 50 seconds.

[0033] As shown in FIGS. 1-10 , button 104 may be coupled to housing 100. Button 104 may be rotatable about longitudinal axis L between a locked position and an unlocked position and may be movable along longitudinal axis L between a pre-fired position and a fired position. A proximal end of button 104 may be closed, and a distal end of button 104 may be open. As shown in FIGS. 11-12 , button 104 may include a button body 136. Button body 136 may have a generally cylindrical shape.

[0034] The button 104 may include a lock indicator 142 thereon to indicate the locked state of the button and / or to indicate that the button 104 is in the locked position. The lock indicator 142 may be stamped, etched, printed, or molded into the button 104. In one embodiment, the lock indicator 142 is a decal secured to the button 104 with an adhesive. In one embodiment, the lock indicator 142 is applied to the button 104 by spray painting, powder coating, silk screening, laser marking, pad printing, or heat staking. The lock indicator 142 may be a graphic of a lock that indicates that the button 104 is in the locked position. The lock indicator 142 may be any combination of shapes and / or words.

[0035] The button 104 may include an unlock indicator 144 thereon to indicate the unlocked state of the button and / or to indicate that the button 104 is in the unlocked position. The unlock indicator 144 may be stamped, etched, printed, or molded into the button 104. In one embodiment, the unlock indicator 144 is a decal secured to the button 104 with an adhesive. In one embodiment, the unlock indicator 144 is applied to the button 104 by spray painting, powder coating, silk screening, laser marking, pad printing, or heat staking. The unlock indicator 144 may be a graphic of a lock that indicates that the button 104 is in the unlocked position. The unlock indicator 144 may be any combination of shapes and / or words.

[0036] The button 104 may further include a rotation indicator 146 to indicate the direction in which the button 104 is movable about the longitudinal axis L. The rotation indicator 146 may be engraved on the button 104. In one embodiment, the rotation indicator 146 is a decal secured to the button 104 with an adhesive. In one embodiment, the rotation indicator 146 is applied to the button 104 by spray painting, powder coating, silk screening, laser marking, pad printing, or heat staking. The rotation indicator 146 may be an arrow that indicates the direction in which the button 104 must be rotated relative to the housing 100 to move from the locked position to the unlocked position. The rotation indicator 146 may be any combination of shapes and / or words.

[0037] Button 104 may further include a translation indicator 148 to indicate the direction in which button 104 is movable along longitudinal axis L. Translation indicator 148 may be engraved on button 104. In one embodiment, translation indicator 148 is a decal secured to button 104 with an adhesive. In one embodiment, translation indicator 148 is affixed to button 104 by spray painting, powder coating, silk screening, laser marking, pad printing, or heat staking. Translation indicator 148 may be an arrow that indicates the direction in which button 104 must be moved relative to housing 100 to transition from the pre-fired position to the fired position. Translation indicator 148 may be any combination of shapes and / or words.

[0038] The button 104 may further include a lockout indicator 150 to indicate that the injector 10 has been fired and that the button 104 is locked in the fired position. The lockout indicator 150 may be engraved on the button 104. In one embodiment, the lockout indicator 150 is a decal secured to the button 104 with an adhesive. In one embodiment, the lockout indicator 150 is applied to the button 104 by spray painting, powder coating, silk screening, laser marking, pad printing, or heat staking. The lockout indicator 150 may be shaped and sized to fill at least a portion of the status window 116 of the housing 100. The lockout indicator 150 may be any combination of shapes and / or words.

[0039] In one embodiment, button 104 includes a partial dose indicator (not shown) of medication, such as a priming amount, at the location of lock indicator 142. The partial dose indicator may be engraved, etched, printed, or molded into button 104. In one embodiment, the partial dose indicator is a decal secured to button 104 with an adhesive. In one embodiment, the partial dose indicator is applied to button 104 by spray painting, powder coating, silk screening, laser marking, pad printing, or heat staking.

[0040] The proximal end of the button body 136 may include one or more ribs 138 extending laterally inward or outward. The one or more ribs 138 may increase friction when a user engages the button 104 and rotates the button 104 about the longitudinal axis L. The button 104 may be configured to rotate 45° about the longitudinal axis L. In some embodiments, the button 104 is configured to rotate 20°, 25°, 30°, 35°, 40°, 45°, 50°, 55°, 60°, 65°, 70°, 75°, 80°, 85°, 90°, 100°, 110°, 120°, 130°, 140°, 150°, 160°, 170°, or 180° about the longitudinal axis L. In some embodiments, button 104 is configured to rotate about longitudinal axis L between 20° and 180°, between 25° and 170°, between 30° and 160°, between 35° and 150°, between 40° and 140°, between 45° and 130°, between 50° and 120°, between 55° and 110°, between 60° and 100°, between 65° and 90°, between 70° and 85°, or between 75° and 80°.

[0041] 11-12, the button 104 may include a button opening 140 extending through the button body 136. The button opening 140 may be located proximate the distal end of the button body 136. The button opening 140 may be shaped and sized to receive a component of the latch 106, as described in more detail below. The button 104 may include two button openings 140 spaced apart on the button body 136. In some embodiments, there is one button opening 140.

[0042] As shown in FIG. 12 , the button 104 may include a fin 152 extending distally from the proximal end of the button 104. The fin 152 may extend from the inner surface of the button 104. The fin 152 may have a generally curved shape similar to the button body 136. The space between the button body 136 and the fin 152 may be the same along the width of the fin 152. The fin may include a ridge 154 extending radially inward along its interior. The ridge 154 may extend along the length of the fin 152. In one embodiment, the ridge 154 may extend from only a portion of the fin 152. The ridge may have a generally rounded shape.

[0043] As shown in FIG. 11 , the button 104 may have a button protrusion 156 extending radially outward from the button body 136. The button protrusion 156 may be disposed between the proximal and distal ends of the button body 136. The button protrusion 156 may be shaped and sized to engage a ledge 158 on the rear housing 114 to prevent the button 104 from moving proximally beyond a predetermined position, as shown in FIG. 7 . The button protrusion 156 may have a generally flat proximal end that engages with the ledge 158. The interaction of the button protrusion 156 with the ledge 158 may allow the button 104 to rotate smoothly relative to the housing 100. The button protrusion 156 may prevent the button 104 from rotating beyond a predetermined amount when the button protrusion 156 engages the end of the ledge 158. The button 104 may further include a rim 157 extending around the button body 136. The rim 157 may prevent deformation of the button 104. In some embodiments, there are multiple rims 157 extending around the periphery of the button body 136, as shown in FIG.

[0044] As shown in FIG. 6 , the latch 106 may be at least partially disposed within the button 104. The button 104 may be capable of rotation and translation relative to the latch 106. As shown in FIG. 13 , the latch 106 may include a latch body 160. The latch body 160 may be generally cylindrical. The latch may include a latch collar 162 extending radially outward therefrom. The latch collar 162 may be disposed at a distal end of the latch body 160. The latch collar 162 may include a collar engagement feature 164 extending radially therefrom. The collar engagement feature 164 may be shaped and sized to be received in a latch receiver 166 of the housing 100. As shown in FIG. 1 , the collar engagement feature 164 may be disposed within the latch receiver 166 when the syringe 10 is assembled. The latch 106 may be fixed relative to the housing 100.

[0045] As shown in FIG. 13 , the latch 106 may include a crown 168 defined on the proximal end of the latch body 160. The crown 168 may be configured to engage the fin 152 of the button. The crown 168 may include one or more detents 170 defined therein. The detents 170 may be shaped and sized to receive the ridges 154 of the fins 152. The crown 168 may further include a surface 172 configured to prevent the button 104 from moving distally relative to the latch 106. As shown in FIG. 13 , the crown 168 may include a locking detent 170 a abutting the surface 172 and an unlocking detent 170 b spaced from the surface 172. When the ridges 154 are received within the locking detent 170 a, the surface 172 may prevent the button 104 from moving along the longitudinal axis L relative to the latch 106. When the ridge 154 is received in the unlock detent 170b, the button may be able to move along the longitudinal axis L relative to the latch 106.

[0046] 13, the latch 106 may include an engagement feature 174 extending from the latch body 160. The engagement feature 174 may be movable between an engaged position and a disengaged position. The engagement feature 174 may include a flexible arm 176 extending along the longitudinal axis L and a protrusion 178 extending radially therefrom. The protrusion 178 may have a generally triangular cross-section and may extend radially inward from the end of the flexible arm 176.

[0047] As shown in FIG. 14 , the ram 108 may be at least partially disposed within the latch 106. The ram 108 may be fixed relative to the latch 106 when the engagement feature 174 is in the engaged position. The ram 108 may be movable relative to the latch 106 when the engagement feature 174 is in the disengaged position. As shown in FIGS. 15-16 , the ram 108 may include a ram body 180. The ram body 180 may be generally cylindrical and may have a closed distal end. The ram body 180 may have a length configured to eject a predetermined amount of medicament. For example, the length of the ram body 180 may be increased to eject a larger volume of medicament or shortened to eject a smaller volume of medicament. The distal end of the ram 108 may be configured to interact with the plunger 128 of the medicament container 102. The distal end of the ram 108 may include a ram protrusion 182 extending therefrom. The ram protrusion 182 may be received within the plunger 128. In some embodiments, the distal end of the ram 108 is flush and does not include the ram protrusion 182 .

[0048] 9-10, the ram 108 may include a ram opening 184 extending through the ram body 180. The ram opening 184 may be sized and shaped to receive at least a portion of the engagement feature 174 when the button 104 is in the pre-fire position. The ram opening 184 may be generally rectangular in shape. As shown in FIG. 13, the ram opening 184 may receive the protrusion 178 of the engagement feature 174 when the engagement feature is in the engaged position.

[0049] Energy source 110 may be configured to bias ram 108 distally relative to latch 106 along longitudinal axis L. As shown in FIG. 14 , energy source 110 may be at least partially disposed within ram 108. A proximal end of energy source 110 may engage a proximal end of latch 106 and a distal end of ram 108. In the exemplary embodiment, energy source 110 includes a compression spring, although other suitable energy sources, such as an electric pump, an elastomeric or compressed gas spring, or a gas generator, or other suitable energy storage member, may be used.

[0050] The energy source 110 may be a compression spring. The energy source 110 may have a diameter of 5 mm. The energy source 110 may have a diameter of 6 mm. The energy source 110 may have a diameter of 7 mm. The energy source 110 may have a diameter of 8 mm. The energy source 110 may have a diameter of 9 mm. The energy source 110 may have a diameter of 10 mm. The energy source 110 may have a diameter of 11 mm. The energy source 110 may have a diameter of 12 mm. The energy source 110 may have a diameter of 13 mm. The energy source 110 may have a diameter of 14 mm. The energy source 110 may have a diameter of 15 mm. The energy source 110 may have a wire diameter of 0.75 mm. The energy source 110 may have a wire diameter of 1 mm. The energy source 110 may have a wire diameter of 1.25 mm. The energy source 110 may have a wire diameter of 1.5 mm. The energy source 110 may have a wire diameter of 1.75 mm. The energy source 110 may have a wire diameter of 2 mm.

[0051] The energy source 110 may generate at least 8 lbf of force, at least 9 lbf of force, at least 10 lbf of force, at least 11 lbf of force, at least 12 lbf of force, at least 13 lbf of force, at least 14 lbf of force, at least 15 lbf of force, at least 16 lbf of force, at least 17 lbf of force, at least 18 lbf of force, at least 19 lbf of force, at least 20 lbf of force, at least 21 lbf of force, at least 22 lbf of force, at least 23 lbf of force, at least 24 lbf of force, at least 25 lbf of force, at least 26 lbf of force, at least 27 lbf of force, at least 28 lbf of force, at least 29 lbf of force, or at least 30 lbf of force. The energy source 110 may generate a force between 8 and 30 lbf, a force between 9 and 29 lbf, a force between 10 and 28 lbf, a force between 11 and 27 lbf, a force between 12 and 26 lbf, a force between 13 and 25 lbf, a force between 14 and 24 lbf, a force between 15 and 23 lbf, a force between 16 and 22 lbf, a force between 17 and 21 lbf, or a force between 18 and 20 lbf.

[0052] The energy source 110 may generate a maximum of 15 lbf of force before the trigger event. The energy source 110 may generate a maximum of 17.5 lbf of force before the trigger event. The energy source 110 may generate a maximum of 20 lbf of force before the trigger event. The energy source 110 may generate a maximum of 22.5 lbf of force before the trigger event. The energy source 110 may generate a maximum of 25 lbf of force before the trigger event. The energy source 110 may generate a maximum of 27.5 lbf of force before the trigger event. The energy source 110 may generate a maximum of 30 lbf of force before the trigger event.

[0053] The energy source 110 may generate a residual force of 8 lbf-force after dispensing the entire volume of fluid from the primary container. The energy source 110 may generate a residual force of 10 lbf-force after dispensing the entire volume of fluid from the primary container. The energy source 110 may generate a residual force of 12 lbf-force after dispensing the entire volume of fluid from the primary container. The energy source 110 may generate a residual force of 14 lbf-force after dispensing the entire volume of fluid from the primary container. The energy source 110 may generate a residual force of 16 lbf-force after dispensing the entire volume of fluid from the primary container. The energy source 110 may generate a residual force of 18 lbf-force after dispensing the entire volume of fluid from the primary container. The energy source 110 may generate a residual force of 20 lbf-force after dispensing the entire volume of fluid from the primary container.

[0054] The ram 108 may be prevented from moving relative to the latch 106 by the button 104 when the button 104 is in the locked position. As shown in FIG. 6 , when the button 104 is in the locked position, the button opening 140 and the engagement feature 174 are misaligned along the longitudinal axis L. Thus, the button body 136 prevents the engagement feature 174 from deflecting radially outward in response to the energy source 110 urging the ram 108 distally. Rotation of the button 104 relative to the longitudinal axis L from the locked position to the unlocked position may align the button opening 140 and the engagement feature 174. As described above, rotation of the button 104 relative to the longitudinal axis L may move the ridge 154 of the fin 152 from the locking detent 170 a to the unlocking detent 170 b. At least a portion of the fin 152 may engage the crown 168 when the button 104 is in the locked position and when the button 104 is in the unlocked position.

[0055] As shown in FIGS. 9-10 , distal movement of the button 104 along the longitudinal axis L relative to the housing from the pre-fired position to the fired position may allow the ram 108 to move relative to the latch 106. Movement of the button 104 to the fired position may cause the button opening 140 to overlap the engagement feature 174. The energy source 110 biasing the ram 108 distally may deflect the engagement feature 174 radially outward. Distal movement of the button 104 to the fired position may allow the engagement feature 174 to deflect radially outward and extend at least partially through the button opening 140. The ram 108 is free to move distally relative to the latch 106 once the engagement feature 174 is received in the button opening 140.

[0056] The ram 108 may engage the plunger 128, thereby moving the plunger 128 relative to the drug container 102 when the button is moved to the fired position. Movement of the plunger 128 relative to the drug container 102 may expel a volume of drug from the drug container 102 through the flange 130. The drug may be expelled through the needle 132 when the needle 132 is coupled to the flange 130.

[0057] After the button 104 is moved from the pre-fire position to the fired position, the button 104 may be prevented from moving proximally relative to the housing 100. The syringe 10 may be a disposable syringe. The radial outward deflection of the engagement features 174 may prevent the button 104 from moving proximally along the longitudinal axis L when the button 104 is in the fired position.

[0058] Provided herein may be a method of delivering a medicament to a subject using a syringe 10. The syringe 10 may include a housing 100 having proximal and distal ends extending along a longitudinal axis L, a medicament container 102 containing a volume of medicament, a button 104 coupled to the housing 100, the button 104 being rotatable about the longitudinal axis L between a locked position and an unlocked position and movable along the longitudinal axis between a pre-fired position and a fired position, a latch 106 at least partially disposed within the button 104, a ram 108 movable relative to the latch 106, and an energy source 110 configured to urge the ram 108 distally along the longitudinal axis L.

[0059] As shown in FIG. 23 , the method may include separating the luer cap 134 from the flange 130 of the drug container 102 with a luer cap remover 186. As described above, the luer cap 134 may be completely recessed within the housing 100. As shown in FIG. 21 , the luer cap remover 186 may include a flange 187 extending radially outward from an end of the luer cap remover 186. The flange 187 may be a generally circular member having a diameter larger than the diameter of the luer cap remover 186. The flange 187 may prevent the luer cap remover 186 from being completely disposed within the housing 100. The flange 187 may include one or more user engagement features 188 defined on its outer end. The user engagement feature 188 may provide a surface for a user to more easily grip and rotate the luer cap remover 186. The user engagement feature 188 may be an indentation in the outer end of the flange 187. In some embodiments, the user engagement feature extends from an outer end of the flange 187. The end of the luer cap remover 186 opposite the user engagement feature 188 may include a luer cap engagement portion 190. The luer cap engagement portion 190 may be shaped and sized to allow the luer cap 134 to be accommodated therein. The luer cap engagement portion 190 may include at least one rib 191 extending radially inward from the interior of the luer cap engagement portion 190 for frictionally engaging the luer cap 134 when disposed therein. The luer cap engagement portion 190 may include a slot 193 defined along its length. The slot 193 may be generally rectangular in shape and may allow the end of the luer cap engagement portion 190 to flex radially inward or outward when disposed within the housing 100 to accommodate the luer cap 134. The luer cap remover 186 may allow a user to rotate the luer cap 134 to remove it from the flange 130 .

[0060] As shown in FIG. 24 , the method may include coupling a needle 132 to the flange 130. The needle 132 may be in fluid communication with the medication container 102 when the needle 132 is coupled thereto. The needle 132 may include a needle shield 192 coupled thereto. The needle shield 192 may provide sharps protection and prevent unintentional needle insertion. The needle shield 192 may include one or more ribs that allow a user to manipulate and rotate the needle 132 to couple the needle 132 to the flange 130. The needle shield 192 may be removed from the needle, as shown in FIG. 24 , to expose the needle 132 for use.

[0061] The method may include rotating the button 104 to an unlocked position. As described above, rotating the button 104 to the unlocked position may align the button opening 140 of the button 104 with the engagement feature 174 of the latch 106. After moving to the unlocked position, the button 104 may be in a pre-fire position. The ram 108 may be prevented from moving relative to the latch 106 by the button 104 in the pre-fire position.

[0062] The method may include inserting at least a portion of the needle 132 into the subject. The needle 132 may be inserted to an insertion depth. Once the needle 132 is inserted into the subject, the method may include moving the button 104 distally relative to the housing 100 to a fired position. In some embodiments, rotation of the button 104 to the unlocked position and moving the button 104 distally along the longitudinal axis L relative to the housing 100 to the fired position may allow the ram 108 to move relative to the latch 106. Moving the button 104 distally to the fired position may overlap the button opening 140 and the engagement feature 174, thereby allowing the engagement feature 174 to flex radially outward and extend at least partially through the button opening 140.

[0063] The method may include expelling a volume of medicament into the subject through the needle 132. The ram 108 may engage a plunger 128 disposed within the medicament container 102, thereby moving the plunger 128 relative to the medicament container 102 when the button 104 is moved to the fired position. In some embodiments, moving the plunger 128 relative to the medicament container 102 expels a volume of medicament from the medicament container 102 through the needle 132. After the button 104 is moved to the fired position, the button 104 may be prevented from moving proximally relative to the housing 100. The method may include removing the needle 132 from the subject after the medicament has been expelled therethrough. The user may discard the syringe 10 after use.

[0064] The terms "about" or "approximately" are used herein to provide literal support for the exact number it precedes, as well as a number that is close to or approximately close to the number it precedes. In determining whether a number is close to or approximately a specifically recited number, the near or approximate unrecited number may be a number that, in the context in which it is presented, provides a substantial equivalent to the specifically recited number. All numerical values ​​and ranges disclosed herein are understood to be approximations, regardless of whether "about" is used in conjunction with them. The term "about," as used herein in connection with a number, is also understood to refer to a value that may be ±0.01% (inclusive), ±0.1% (inclusive), ±0.5% (inclusive), ±1% (inclusive), ±2% (inclusive), ±3% (inclusive), ±5% (inclusive), ±10% (inclusive), or ±15% (inclusive) of that number. It should be further understood that when a range of numerical values ​​is disclosed herein, any number falling within that range is also specifically disclosed.

[0065] Those skilled in the art will appreciate that changes can be made to the exemplary embodiments shown and described above without departing from the broad inventive concept thereof. It is to be understood that the embodiments and claims disclosed herein are not limited in their application to the details of construction and arrangement of components set forth in the description and illustrated in the drawings. Rather, the description and drawings provide examples of contemplated embodiments. The embodiments and claims disclosed herein furthermore are capable of other embodiments and of being practiced and carried out in various ways.

[0066] Certain features of exemplary embodiments may or may not be part of a claimed invention, and various features of the disclosed embodiments may be combined. Unless specifically stated herein, the terms "a," "an," and "the" are not limited to one element and should instead be read to mean "at least one." Finally, unless specifically stated herein, the disclosed or claimed methods should not be limited to performing their steps in the order described; one of ordinary skill in the art can readily understand that steps can be performed in any actual order.

Claims

1. a housing having proximal and distal ends extending along a longitudinal axis; a medication container containing a volume of medication; a button coupled to the housing, the button being rotatable about the longitudinal axis between a locked position and an unlocked position and movable along the longitudinal axis between a pre-fired position and a fired position; a latch at least partially disposed within the button; a ram movable relative to the latch; an energy source configured to urge the ram distally along the longitudinal axis; and A syringe comprising: the ram is prevented from moving relative to the latch by the button in the pre-fire position; A syringe wherein rotation of the button to the unlocked position and movement of the button distally along the longitudinal axis relative to the housing to the fired position allows the ram to move relative to the latch.

2. 10. The syringe of claim 1, wherein the button includes a button body, a button opening extending through the button body, and a fin extending distally from a proximal end of the button body.

3. 3. The syringe of claim 2, wherein the latch includes a latch body, a crown defined at a proximal end of the latch body configured to engage the fin of the button, and an engagement feature extending from the latch body, the engagement feature being movable between an engaged position and a disengaged position.

4. 4. The syringe of claim 3, wherein at least a portion of said fin engages said crown when said button is in said locked position and said unlocked position.

5. The ram includes a ram body and a ram opening extending through the ram body, the ram opening configured to receive at least a portion of the engagement feature when the button is in the pre-fire position; 4. The syringe of claim 3, comprising:

6. The engagement feature may include: a flexible arm extending along the longitudinal axis; a protrusion extending radially therefrom; and The syringe of claim 3 , comprising:

7. The syringe of claim 6 , wherein the protrusion extends radially inward from the end of the flexible arm.

8. The syringe of claim 3 , wherein rotation of the button to the unlocked position aligns the button opening with the engagement feature.

9. 9. The syringe of claim 8, wherein distal movement of the button to the fired position allows the engagement features to flex radially outward and extend at least partially through the button opening.

10. The medication container includes a luer lock extending from a distal end thereof, and the syringe includes: A plunger disposed within the luer lock The syringe of claim 1 further comprising:

11. 11. The syringe of claim 10, wherein the ram engages the plunger, thereby moving the plunger relative to the medication container when the button is moved to the fired position.

12. 12. The syringe of claim 11, wherein movement of the plunger relative to the medication container expels the volume of the medication from the medication container via the luer lock.

13. a needle coupled to the luer lock, the needle being in fluid communication with the medication container; 11. The syringe of claim 10, further comprising:

14. a luer cap removably coupled to the luer lock in a storage configuration; 11. The syringe of claim 10, wherein the luer cap is completely recessed within the housing.

15. 10. The syringe of claim 1, wherein the button is prevented from moving proximally relative to the housing after the button is moved from the pre-fired position to the fired position.

16. 10. The syringe of claim 1, wherein the volume of the medication is at least 10 mL.

17. the latch is fixed relative to the housing; The syringe of claim 1 , wherein the medication container is fixed relative to the housing.

18. a housing having proximal and distal ends extending along a longitudinal axis; a medication container containing a volume of medication; a button coupled to the housing and rotatable between a locked position and an unlocked position, The button body and a button opening extending through the button body; a fin extending distally from the proximal end of the button body; a button; a latch at least partially disposed within the button, A latch body; a crown defined on a proximal end of the latch body configured to engage the fin of the button; an engagement feature extending from the latch body, the engagement feature being movable between an engaged position and a disengaged position; a latch comprising: a ram movable relative to the latch, The ram body and a ram opening extending through the ram body, the ram opening configured to receive at least a portion of the engagement feature when the button is in the pre-fire position; a ram, an energy source configured to urge the ram distally along the longitudinal axis; and A syringe comprising: the ram is prevented from moving relative to the latch by the button in the locked position; A syringe wherein rotation of the button to the unlocked position and movement of the button distally along the longitudinal axis relative to the housing to the fired position allows the ram to move relative to the latch.

19. 1. A method of delivering a medicament to a subject using a syringe, the syringe comprising: a housing having proximal and distal ends extending along a longitudinal axis; a medicament container containing a volume of medicament; a button coupled to the housing, the button rotatable about the longitudinal axis between locked and unlocked positions and movable along the longitudinal axis between pre-fired and fired positions; a latch at least partially disposed within the button; a ram movable relative to the latch; and an energy source configured to urge the ram distally along the longitudinal axis; separating a luer cap from a luer lock of the drug container with a luer cap remover, the luer cap being fully recessed within the housing; coupling a needle to the luer lock, the needle being in fluid communication with the medication container; rotating the button to the unlocked position; inserting at least a portion of the needle into the object; moving the button distally relative to the housing to the fired position; releasing the volume of the agent into the subject through the needle; removing the needle from the object; A method comprising:

20. 20. The method of claim 19, wherein the ram is prevented from moving relative to the latch by the button in the pre-fire position.

21. 21. The method of claim 20, wherein rotation of the button to the unlocked position and movement of the button distally along the longitudinal axis relative to the housing to a fired position allows the ram to move relative to the latch.

22. rotating the button to the unlocked position to align a button opening of the button with an engagement feature of the latch.

20. The method of claim 19, further comprising:

23. moving the button distally to the fired position, thereby allowing the engagement features to flex radially outward and extend at least partially through the button opening.

23. The method of claim 22, further comprising:

24. 20. The method of claim 19, wherein the ram engages a plunger disposed within the medication container, thereby moving the plunger relative to the medication container when the button is moved to the fired position.

25. 25. The method of claim 24, wherein moving the plunger relative to the medication container expels the volume of the medication from the medication container through the needle.

26. 20. The method of claim 19, wherein the button is prevented from moving proximally relative to the housing after the button is moved to the fired position.

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