KRAS modulator and its usage

Abstract

Formula (I), (IA), (IB), (IC), (IC * KRAS modulatory compounds such as compounds of (ID), (IE), (IF), (IG), (IH), (II), (IJ), or any one thereof, such as pharmaceutically acceptable salts, solvates, stereoisomers, labeled atoms, or tautomers. The compounds provided herein are useful for modulating KRAS GD12 and / or other G12 mutants.

Description

[Technical Field]

[0001] cross reference This application claims the interests of U.S. Provisional Patent Application No. 63 / 490,475, filed on 15 March 2023, and U.S. Provisional Patent Application No. 63 / 508,213, filed on 14 June 2023; the entire contents of each of these are incorporated herein by reference. [Background technology]

[0002] background The small GTPase protein Kirsten rat sarcoma 2 virus oncogene homolog (KRAS) is a member of the Ras family of cellular signaling switches that regulate the growth and survival of both normal and cancer cells (see, e.g., Cully, M. and J. Downward, SnapShot: Ras Signaling. Cell, 2008. 133(7): p. 1292-1292 e1). KRAS mutations drive approximately 25% of human cancers by abnormally regulating the mitogen-activated protein kinase (MAPK) signaling cascade and other effector pathways (see, e.g., Stephen, AG, et al., Dragging ras back in the ring. Cancer Cell, 2014. 25(3): p. 272-81). Although Ras has been recognized as a target in cancer for about 40 years, Ras-driven cancers remain among the most difficult to treat due to their insensitivity to available targeted therapies. Ras, encoded by three main genes—KRAS, NRAS, and HRAS—have the highest frequency of mutations among all oncogenes. All oncogenic Ras mutations drive a switch that accumulates in an active GTP-bound state. The most common Ras mutation found across human tumor types is KRAS G12D (see, e.g., The AACR Project GENIE Consortium. Cancer Discovery, 2017. 7(8): p. 818-831. Dataset Version 4). The activating mutation at codon 12 impairs the ability of small GTPases, which perform their role in hydrolyzing GTP. This dysregulation is fundamental to initiating and maintaining tumor progression.

[0003] Despite considerable effort, no small molecules have been identified that block effector binding or restore GTPase-activating protein (GAP) sensitivity, although several have been found that block the interaction between Ras and SOS, a guanine nucleotide exchange factor (GEF) that activates Ras at the cell membrane. The KRAS G12C mutation, the most common in lung adenocarcinoma, has been clinically shown to be sensitive to direct inhibition by covalent modification with small molecule inhibitors that trap the protein in an inactive GDP-bound state. KRAS G12D mutations confer a significantly slower intrinsic rate of GTP hydrolysis than G12C, resulting in more constitutive activation. Therefore, pharmacological targeting of the inactive state is unlikely to achieve similar results for G12D, despite the presence of a similar binding pocket in the GDP state. In addition, while cysteine ​​present at the site of the activating mutation is utilized in covalent chemistry, aspartic acid does not offer a typical medicinal chemistry approach for selective covalent modification. Selective binding to the GTP state and stabilization of conformations unsuitable for oncogenic signaling interactions with effector proteins are attractive features for small molecule inhibitors, as they allow for selective inhibition of cancer cells by potentially exploiting the accumulation of KRAS G12D and other mutant variants in the GTP-bound state as a vulnerability while preserving normal Ras function. Furthermore, it has been shown that only constitutive activation of Raf, MEK, and ERK kinases in the downstream MAPK cascade of Ras can bypass the requirements for the Ras protein in proliferative signaling (see, e.g., Drosten, M., et al., Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. EMBO J, 2010. 29(6): p. 1091-104). All evidence indicates that MAPK signaling is essential for the growth effect of Ras in cancer, so selective inhibition of KRAS mutants in this pathway is considered a key functional leadout for potential clinical benefits of novel therapeutic approaches. Therefore, there is a need to develop novel inhibitors for KRAS-driven cancers that demonstrate inhibition of MAPK signaling through a mechanism of action that is selective to binding to the active GTP-bound state rather than the inactive GDP-bound state. [Prior art documents] [Non-patent literature]

[0004] [Non-Patent Document 1] Cully, M. and J. Downward, SnapShot: Ras Signaling. Cell, 2008. 133(7): p. 1292-1292 e1 [Non-Patent Document 2] Stephen, AG, et al., Dragging ras back in the ring. Cancer Cell, 2014. 25(3): p. 272-81

Non-Patent Document 3

Non-Patent Document 4

Summary of the Invention

Means for Solving the Problems

[0005] Gist of the Invention In one aspect, the present disclosure provides a compound represented by formula (I),

Chemical formula

Chemical formula

[0006] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from; R 1A C 1~6 Alkyl, C3~C 12 Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 11 Replaced as needed, R 1A Two R on the same atom 11 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 11A Each is replaced as needed; R 1B is hydrogen, C 1~6 Selected from alkyl and C3-C6 carbon rings, C 1~6 Alkyl and C3-C6 carbon rings are one or more R 10 Are they replaced as needed? Or R 1A and R 1B Together with the atoms they bond to, R 1 Forms R 1 It is a 5-15 member heterocycle, and 5-15 member heterocycles are halogens, -B(OR 20 )2, -N(R 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20)2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(=NR 20 )N(R 20 )2, -C 1~6 Alkyl (=NR) 20 Ure 20 ), -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl-SO2R 20 , C 1~6 Alkoxyalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Optionally substituted with one or more substituents independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles contain one or more R 1* They are independently replaced as needed; Each R 1* is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, and C3~C 12 Selected independently from the carbon ring; R 1C is hydrogen, C 1~6 Alkyl, C3~C 12 Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 12 Replaced as needed, R 1C Two R on the same atom 12 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 12A Each is replaced as needed; R1D is hydrogen, C 1~6 Alkyl, C3~C 12 Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 13 Replaced as needed, R 1D Two R on the same atom 13 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 13A Each is replaced as needed; Y is -O-; R 2 is a heteroalgebra, -L-heteroalgebra, -LN(R 20 )2, -L-OR 20 -L-aryl, -L-heteroaryl, -L-cycloalkyl, -L-NHC(=NH)NH2, -LC(O)N(R 20 )2, -L-C1~C6 haloalkyl, -L-NR 20 C(O)-aryl, -L-COOH, -L-NR 20 S(O)2(R 20 ), -LS(O)2N(R 20 )2, -LN(R 20 )C(O)(OR 20 ), -L-OC(O)N(R 20 )2, and selected from -LC(=O)OC1~C6 alkyl, the heterocycle, the heterocyclic moiety of the -L-heterocycle, and the cycloalkyl moiety of the -L-cycloalkyl are one or more R 6 These are replaced as needed, -L-NR 20 The aryl portion of C(O)-aryl, the aryl portion of -L-aryl, and the heteroaryl portion of -L-heteroaryl are one or more R 7 Each is replaced as needed; Each L stands for halogen, hydroxyl, and C. 1~6Independently selected from C1-C4 alkylenes optionally substituted with one or more substituents independently selected from alkoxy, C1-C4 hydroxyalkyl, C1-C4 alkyl, C3-C6 carbon rings, and 3-8 membered heterocycles, wherein the C3-C6 carbon rings and 3-8 membered heterocycles are halogens, -OH, -NO2, =O, =S, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Each is optionally substituted with one or more substituents independently selected from the haloalkyl group; optionally, two substituents on the same carbon atom of L may combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, where the C3-C6 carbon ring and 3-8 membered heterocycle are halogen, -OH, -NO2, =O, =S, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, and C 1~6 Each substituent is optionally substituted with one or more substituents independently selected from the haloalkyl group; Each R 4 These are halogen, -NO2, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,=O,=S,-CN,C 1~6 Alkyl, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Cyanoalkyl, C 1~6 Hydroxyalkyl, and C 1~6 Independently selected from haloalkyl groups; n is selected from 0, 1, 2, 3, and 4; m is selected from 1 and 2; Each R 5 These are independently selected from hydrogen and C1-C6 alkyl groups; Each R 6Halogen, hydroxy, C1-C3 hydroxyalkyl, C1-C3 alkyl, oxo, C1-C3 haloalkyl, C1-C3 alkyl-N3, C1-C3 alkoxy, cyano, =CH2, =NO-C1-C3 alkyl, C1-C3 aminoalkyl, -N(R) 5 )S(O)2(R 5 ), -Q-phenyl, -Q-phenylSO2F, -NHC(O)phenyl, -NHC(O)phenylSO2F, C1~C3 alkyl-substituted pyrazolyl, tert-butyldimethylsilyloxyCH2-, -N(R 5 )2, (C1~C3 alkoxy)C1~C3 alkyl-, (C1~C3 alkyl)C(=O), oxo, (C1~C3 haloalkyl)C(=O)-, -SO2F, (C1~C3 alkoxy)C1~C3 alkoxy, -CH2OC(O)N(R 5 )2,-CH2NHC(O)OC1~C6 alkyl,-CH2NHC(O)N(R 5 )2, -CH2NHC(O)C1~C6 alkyl, -CH2(pyrazolyl), -CH2NHSO2C1~C6 alkyl, -CH2OC(O) heterocycle, -OC(O)N(R 5 )2,-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl),-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl)phenyl(C1~C3alkyl)N(CH3)2,-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl)phenyl,-OC(O)heterocycle,-O-C1~C3alkyl,-S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20Independently selected from the -CH2 heterocycle, the phenyl in -NHC(O)phenyl and -OC(O)NH(C1~C3 alkyl)(C1~C3 alkyl)phenyl is optionally substituted with one or more substituents selected from -C(O)H and OH, the alkyl in -O-C1~C3 alkyl is optionally substituted with substituents selected from heterocycle, oxo and hydroxyl; the heterocycle of -CH2 heterocyclil is optionally substituted with oxo; Each Q is selected from joins and O; Each R 7 These include halogens, hydroxyls, HC(=O)-, C1-C4 alkyls, C1-C4 alkoxys, C1-C4 haloalkyls, C1-C4 hydroxyalkyls, and -N(R) 5 ) Selected independently from 2; R 8 The 5- to 12-membered heterocycles are selected from halogens, -CN, -NO2, =O, -N(R) 20 )2, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -C(O)NR 20 -OR 20 , C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Substituting as necessary with one or more substituents independently selected from carbocyclic and 5- to 12-membered heterocycles; R 9 These are hydrogen, halogen, -CN, -NO2, -N(R) 20 )2, -OR 20 , -SR 20 , C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkynyl and selected from C3-C6 carbon rings, where the C3-C6 carbon ring contains one or more halogens, -CN, -NO2, -N(R) 20 )2, -OR 20 , -SR 20 , C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Is it substituted as needed with alkynyl; or R 8 and R 9 These, together with the atoms they bond to, form B, which is a 7-15 membered heterocycle and C7-C 15 Selected from carbon rings, 7-15 membered heterocycles and C7-C 15The carbon ring is a halogen, -CN, -NO2, =O, -N(R) 20 )2, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Each is optionally substituted with one or more substituents independently selected from the carbocyclic and 5- to 12-membered heterocycles; Each R 10 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles are halogens, -OH, -CN, -NO2, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Each substituent is optionally substituted with one or more substituents independently selected from alkyl and oxo; Each R 11 , R 12 , and R 13 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles are halogens, -OH, -CN, -NO2, -N(R) 21 )2, -SR 21 ,-C(O)N(R 21 )2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Each substituent is optionally substituted with one or more substituents independently selected from alkyl and oxo; Each R 11A , R 12A , and R 13A is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Selected independently of Alkinnir; Each R 20 hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Alkyl, oxo, C 3~12 C as needed, substituted with one or more substituents independently selected from carbocyclic and 3- to 12-membered heterocycles. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~12 Independently selected from carbon rings and 3- to 12-membered heterocycles; Each R 21 hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, -N(C) 1~6 Alkyl)2, C 1~10 Alkyl, -C1~10 Haloalkyl, -OC 1~10 Alkyl, oxo, C 3~12 C as needed, substituted with one or more substituents independently selected from carbocyclic and 3- to 12-membered heterocycles. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~12 They are independently selected from carbon rings and 3- to 12-membered heterocycles.

[0007] In certain embodiments, the disclosure provides a pharmaceutical composition comprising a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), and pharmaceutically acceptable additives.

[0008] In certain embodiments, the Disclosure provides a method for treating a disease or disorder using a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ).

[0009] In certain embodiments, the Disclosure provides a method for treating a disease or disorder using a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), and pharmaceutically acceptable additives.

[0010] In certain embodiments, the disclosure provides a method for inhibiting KRas G12D and / or other G12 mutants using a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ).

[0011] In certain embodiments, the Disclosure provides a method for inhibiting KRas G12D and / or other G12 mutants using a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), and pharmaceutically acceptable additives. Embedding by reference

[0012] All publications, patents, and patent applications cited herein are incorporated by reference to the same extent as each individual publication, patent, or patent application is specifically and individually indicated to be incorporated by reference. [Modes for carrying out the invention]

[0013] Detailed description of the invention The following description includes numerous exemplary configurations, methods, parameters, etc. However, it should be recognized that such descriptions are provided instead as descriptions of exemplary embodiments and are not intended as limitations on the scope of this disclosure.

[0014] In the following description, certain specific details are provided to provide a thorough understanding of the various embodiments of this disclosure. However, those skilled in the art will understand that this disclosure may be carried out without these details. definition

[0015] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which this invention pertains. All patents and publications referenced herein are incorporated herein by reference.

[0016] "Alkyl" refers to a linear or branched hydrocarbon chain radical consisting only of carbon and hydrogen atoms that does not contain unsaturated atoms, preferably having 1 to 15 carbon atoms (i.e., C1 to C15). 15Alkyl). In certain embodiments, alkyl contains 1 to 13 carbon atoms (i.e., C1 to C13). 13 Alkyl). In certain embodiments, the alkyl group contains 1 to 8 carbon atoms (i.e., C1-C8 alkyl). In other embodiments, the alkyl group contains 1 to 5 carbon atoms (i.e., C1-C5 alkyl). In other embodiments, the alkyl group contains 1 to 4 carbon atoms (i.e., C1-C4 alkyl). In other embodiments, the alkyl group contains 1 to 3 carbon atoms (i.e., C1-C3 alkyl). In other embodiments, the alkyl group contains 1 to 2 carbon atoms (i.e., C1-C2 alkyl). In other embodiments, the alkyl group contains 1 carbon atom (i.e., C1 alkyl). In other embodiments, the alkyl group contains 5 to 15 carbon atoms (i.e., C5-C 15 Alkyl). In other embodiments, the alkyl group contains 5 to 8 carbon atoms (i.e., C5 to C8 alkyl). In other embodiments, the alkyl group contains 2 to 5 carbon atoms (i.e., C2 to C5 alkyl). In other embodiments, the alkyl group contains 3 to 5 carbon atoms (i.e., C3 to C5 alkyl). In certain embodiments, the alkyl group is selected from methyl, ethyl, 1-propyl (n-propyl), 1-methylethyl (iso-propyl), 1-butyl (n-butyl), 1-methylpropyl (sec-butyl), 2-methylpropyl (iso-butyl), 1,1-dimethylethyl (tert-butyl), and 1-pentyl (n-pentyl). The alkyl group is attached to the remainder of the molecule by a single bond.

[0017] "C x~y " or "C x ~C y The term "C" means, when used in conjunction with a chemical part, such as alkyl, alkenyl, or alkynyl, a group containing x to y carbon atoms in the chain. For example, "C 1~6 The terms "alkyl" or "C1-C6 alkyl" refer to substituted or unsubstituted saturated hydrocarbon groups containing 1 to 6 carbon atoms, including linear or branched alkyl groups. x~yThe term alkylene- refers to a substituted or unsubstituted alkylene chain having x to y carbon atoms in the alkylene chain. For example, -C 1~6 The alkylene can be selected from methylene, ethylene, propylene, butylene, pentylene, and hexylene, one of which may be substituted as needed.

[0018] "Alkoxy" refers to a radical bonded through an oxygen atom of the formula -O-alkyl (where alkyl is the alkyl chain as defined above).

[0019] "Alkenyl" refers to a linear or branched hydrocarbon chain radical group consisting only of carbon atoms and hydrogen atoms, containing at least one carbon-carbon double bond, preferably having 2 to 12 carbon atoms (i.e., C2 to C2). 12 Alkenyls. In certain embodiments, alkenyls contain 2 to 8 carbon atoms (i.e., C2-C8 alkenyls). In certain embodiments, alkenyls contain 2 to 6 carbon atoms (i.e., C2-C6 alkenyls). In other embodiments, alkenyls contain 2 to 4 carbon atoms (i.e., C2-C4 alkenyls). Alkenyls are attached to the rest of the molecule by single bonds, such as ethenyl (i.e., vinyl), propa-1-enyl (i.e., allyl), buta-1-enyl, penta-1-enyl, penta-1,4-dienyl, etc.

[0020] "Alkynyl" refers to a linear or branched hydrocarbon chain radical group consisting only of carbon atoms and hydrogen atoms, containing at least one carbon-carbon triple bond, preferably having 2 to 12 carbon atoms (i.e., C2 to C2). 12Alkynnyls. In certain embodiments, the alkynyl contains 2 to 8 carbon atoms (i.e., C2-C8 alkynyls). In other embodiments, the alkynyl contains 2 to 6 carbon atoms (i.e., C2-C6 alkynyls). In other embodiments, the alkynyl contains 2 to 4 carbon atoms (i.e., C2-C4 alkynyls). Alkynnyls are attached to the remainder of the molecule by single bonds, such as ethynyl, propynyl, butynyl, pentynyl, and hexynyl.

[0021] "C x~y "Alkenil" and "C x~y The term "alkynyl" refers to a substituted or unsubstituted unsaturated aliphatic group analog containing at least one double or triple bond, but with respect to the length and possible substitutions for the alkyl group described above. -C x~y The term "-alkenylene" refers to a substituted or unsubstituted alkenylene chain having x to y carbon atoms in the alkenylene chain. For example, -C 2~6 The alkenylene- can be selected from etenylene, propenylene, butenylene, pentenylene, and hexenylene, one of which may be substituted as needed. The alkenylene chain may have one or more double bonds in the alkenylene chain. -C x~y The term -alkylene refers to a substituted or unsubstituted alkylene chain having x to y carbon atoms in the alkylene chain. For example, -C 2~6 The alkenylene- can be selected from ethynylene, propynylene, butynylene, pentynylene, and hexynylene, one of which may be substituted as needed. The alkynylene chain may have one or more triple bonds.

[0022] An "alkylene" or "alkylene chain" refers to a linear or branched divalent hydrocarbon chain consisting only of carbon and hydrogen, without unsaturation, with the remainder of the molecule linked to a radical group, preferably having 1 to 12 carbon atoms, such as methylene, ethylene, propylene, or n-butylene. The alkylene chain attaches to the remainder of the molecule and to the radical group through single bonds. The attachment points of the alkylene chain to the remainder of the molecule and to the radical group can be through any two carbon atoms in the chain. In certain embodiments, the alkylene contains 1 to 10 carbon atoms (i.e., C1-C8 alkylene). In certain embodiments, the alkylene contains 1 to 8 carbon atoms (i.e., C1-C8 alkylene). In other embodiments, the alkylene contains 1 to 5 carbon atoms (i.e., C1-C5 alkylene). In other embodiments, the alkylene contains 1 to 4 carbon atoms (i.e., C1-C4 alkylene). In other embodiments, the alkylene contains 1 to 3 carbon atoms (i.e., C1-C3 alkylene). In other embodiments, the alkylene contains 1 to 2 carbon atoms (i.e., C1-C2 alkylene). In other embodiments, the alkylene contains 1 carbon atom (i.e., C1 alkylene). In other embodiments, the alkylene contains 5 to 8 carbon atoms (i.e., C5-C8 alkylene). In other embodiments, the alkylene contains 2 to 5 carbon atoms (i.e., C2-C5 alkylene). In other embodiments, the alkylene contains 3 to 5 carbon atoms (i.e., C3-C5 alkylene).

[0023] An "alkenylene" or "alkenylene chain" refers to a linear or branched divalent hydrocarbon chain consisting only of carbon and hydrogen, containing at least one carbon-carbon double bond, with the remainder of the molecule linked to a radical group, preferably having 2 to 12 carbon atoms. The alkenylene chain attaches to the remainder of the molecule and to the radical group through single bonds. The attachment points of the alkenylene chain to the remainder of the molecule and to the radical group can be through any two carbon atoms in the chain. In certain embodiments, the alkenylene contains 2 to 10 carbon atoms (i.e., C2 to C2). 10Alkenylenes). In certain embodiments, alkenylenes contain 2 to 8 carbon atoms (i.e., C2-C8 alkenylenes). In other embodiments, alkenylenes contain 2 to 5 carbon atoms (i.e., C2-C5 alkenylenes). In other embodiments, alkenylenes contain 2 to 4 carbon atoms (i.e., C2-C4 alkenylenes). In other embodiments, alkenylenes contain 2 to 3 carbon atoms (i.e., C2-C3 alkenylenes). In other embodiments, alkenylenes contain 2 carbon atoms (i.e., C2 alkenylenes). In other embodiments, alkenylenes contain 5 to 8 carbon atoms (i.e., C5-C8 alkenylenes). In other embodiments, alkenylenes contain 3 to 5 carbon atoms (i.e., C3-C5 alkenylenes).

[0024] An "alkynylene" or "alkynylene chain" refers to a linear or branched divalent hydrocarbon chain consisting only of carbon and hydrogen, containing at least one carbon-carbon triple bond, with the remainder of the molecule linked to a radical group, preferably having 2 to 12 carbon atoms. The alkynylene chain attaches to the remainder of the molecule and to the radical group through single bonds. The attachment points of the alkynylene chain to the remainder of the molecule and to the radical group can be through any two carbon atoms in the chain. In certain embodiments, the alkynylene contains 2 to 10 carbon atoms (i.e., C2 to C2). 10 Alkynylene). In certain embodiments, the alkynylene contains 2 to 8 carbon atoms (i.e., C2-C8 alkynylene). In other embodiments, the alkynylene contains 2 to 5 carbon atoms (i.e., C2-C5 alkynylene). In other embodiments, the alkynylene contains 2 to 4 carbon atoms (i.e., C2-C4 alkynylene). In other embodiments, the alkynylene contains 2 to 3 carbon atoms (i.e., C2-C3 alkynylene). In other embodiments, the alkynylene contains 2 carbon atoms (i.e., C2 alkynylene). In other embodiments, the alkynylene contains 5 to 8 carbon atoms (i.e., C5-C8 alkynylene). In other embodiments, the alkynylene contains 3 to 5 carbon atoms (i.e., C3-C5 alkynylene).

[0025] The term "aryl" refers to a radical derived from an aromatic monocyclic or aromatic polycyclic hydrocarbon ring system by removing a hydrogen atom from a ring carbon atom. An aromatic monocyclic or aromatic polycyclic hydrocarbon ring system contains only hydrogen and carbon atoms, and contains 5 to 18 carbon atoms, where at least one of the rings in the ring system is aromatic; that is, it contains a cyclic delocalized (4n+2)π electron system according to Hückel's rule. Examples of ring systems from which an aryl group is derived include, but are not limited to, benzene, fluorene, indan, indene, tetralin, and naphthalene.

[0026] "Aralkill" is formula -R c -aryl(in the formula, R) c This refers to the radical of an alkylene chain (such as methylene or ethylene) as defined above.

[0027] "Aralkenyl" is expressed by formula -R d -aryl(in the formula, R) d The term "aralquinyl" refers to the radical of the alkenylene chain (as defined above). e -aryl(in the formula, R) e This refers to the radical of the alkynylene chain (as defined above).

[0028] A "carbocyclic ring" refers to a saturated, unsaturated, or aromatic ring in which each atom of the ring is carbon. Carbocyclic rings may include 3- to 10-membered monocyclic rings, 6- to 12-membered bicyclic rings, and 6- to 12-membered bridging rings. Each ring in a bicyclic carbocyclic ring may be selected from saturated, unsaturated, and aromatic rings. An aromatic ring, for example, phenyl, may be fused to a saturated or unsaturated ring, for example, cyclohexane, cyclopentane, or cyclohexene. Any combination of saturated, unsaturated, and aromatic bicyclic rings is included in the definition of a carbocyclic ring, provided that valency is acceptable. Exemplary carbocyclic rings include cyclopentyl, cyclohexyl, cyclohexenyl, adamantyl, phenyl, indanyl, and naphthyl. Bicyclic carbocyclic rings may be condensed, bridging, or spirocyclic systems. In some cases, the carbocyclic rings of a spirocyclic ring have at least two molecular rings sharing only one common atom.

[0029] The term "unsaturated carbocyclic ring" refers to a carbocyclic ring having at least one degree of unsaturation, excluding aromatic carbocyclic rings. Examples of unsaturated carbocyclic rings include cyclohexadiene, cyclohexene, and cyclopentene.

[0030] "Cycloalkyl" refers to a fully saturated monocyclic or polycyclic hydrocarbon radical consisting only of carbon and hydrogen atoms, which includes condensed or crosslinked ring systems and preferably has 3 to 12 carbon atoms. In certain embodiments, the cycloalkyl contains 3 to 10 carbon atoms. In other embodiments, the cycloalkyl contains 5 to 7 carbon atoms. The cycloalkyl may be attached to the remainder of the molecule by single bonds. Examples of monocyclic cycloalkyls include, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Examples of polycyclic cycloalkyl radicals include, for example, adamantyl, norbornyl (i.e., bicyclo[2.2.1]heptanyl), norborneyl, dekalinyl, and 7,7-dimethyl-bicyclo[2.2.1]heptanyl.

[0031] A "cycloalkenyl" refers to an unsaturated, non-aromatic monocyclic or polycyclic hydrocarbon radical consisting only of carbon and hydrogen atoms, which preferably includes a condensed or bridging ring system having 3 to 12 carbon atoms and containing at least one double bond. In certain embodiments, the cycloalkenyl contains 3 to 10 carbon atoms. In other embodiments, the cycloalkenyl contains 5 to 7 carbon atoms. The cycloalkenyl may be attached to the remainder of the molecule by single bonds. Examples of monocyclic cycloalkenyls include, for example, cyclopentenyl, cyclohexenyl, cycloheptenyl, and cyclooctenyl.

[0032] "Cycloalkylalkyl" is defined by formula -R c -Cycloalkyl(wherein R) c This refers to the radical of the alkylene chain described above.

[0033] "Cycloalkylalkoxy" is a compound of the formula -OR c -Cycloalkyl(wherein R) c This refers to a radical bonded through the oxygen atom of the alkylene chain described above.

[0034] "Halo" or "halogen" refers to halogen substituents, such as bromo, chloro, fluoro, and iodo substituents.

[0035] As used herein, the terms “haloalkyl” or “haloalkane” refer to the alkyl radicals defined above, such as trifluoromethyl, dichloromethyl, bromomethyl, 2,2,2-trifluoroethyl, 1-fluoromethyl-2-fluoroethyl, etc., which are substituted with one or more halogen radicals. In some embodiments, the alkyl portion of the fluoroalkyl radical is further substituted as needed. Examples of halogen-substituted alkanes ("haloalkanes") include halomethanes (e.g., chloromethane, bromomethane, fluoromethane, iodomethane), di and trihalomethanes (e.g., trichloromethane, tribromomethane, trifluoromethane, triiodomethane), 1-haloethane, 2-haloethane, 1,2-dihaloethane, 1-halopropane, 2-halopropane, 3-halopropane, 1,2-dihalopropane, 1,3-dihalopropane, 2,3-dihalopropane, 1,2,3-trihalopropane, as well as any other suitable combination of alkanes (or substituted alkanes) and halogens (e.g., Cl, Br, F, I, etc.). If the alkyl group is substituted with one or more halogen radicals, each halogen can be independently selected, for example, 1-chloro,2-fluoroethane.

[0036] "Fluoroalkyl" refers to the alkyl radicals defined above, which are substituted by one or more fluororadicals, such as trifluoromethyl, difluoromethyl, fluoromethyl, 2,2,2-trifluoroethyl, and 1-fluoromethyl-2-fluoroethyl.

[0037] "Aminoalkyl" refers to the alkyl radicals defined above, which are substituted by one or more amine radicals, such as propan-2-amine, butane-1,2-diamine, and pentane-1,2,4-triamine.

[0038] "Hydroxyalkyl" refers to the alkyl radicals defined above, which are substituted by one or more hydroxyl radicals, such as propan-1-ol, butane-1,4-diol, pentane-1,2,4-triol, etc.

[0039] "Alkoxyalkyl" refers to the alkyl radicals defined above, such as methoxymethane, 1,3-dimethoxybutane, 1-methoxypropane, and 2-ethoxypentane, which are substituted by one or more alkoxy radicals.

[0040] When used herein, "cyanoalkyl" refers to the alkyl radicals defined above, such as acetonitrile, 2-ethyl-3-methylsuccinonitrile, butyronitrile, etc., which are substituted by one or more cyano radicals.

[0041] A "heterocycle" refers to a saturated, unsaturated, or aromatic ring containing one or more heteroatoms. Exemplary heteroatoms include N, O, Si, P, B, Se, and S atoms. Heterocycles include 3- to 10-membered monocyclic rings, 6- to 12-membered bicyclic rings, and 6- to 12-membered bridging rings. Each ring in a bicyclic heterocycle can be selected from saturated, unsaturated, and aromatic rings. Bicyclic heterocycles can be fused, bridging, or spirocycle systems. In some cases, a spirocycle heterocycle has at least two molecular rings sharing only one common atom. A spirocycle heterocycle contains at least one heteroatom.

[0042] A "heterocyclene" refers to a divalent heterocycle in which the remainder of a molecule is linked to a radical group.

[0043] A "heteroaryl" or "aromatic heterocycle" refers to a radical derived from a heteroaromatic ring radical containing 1 to 11 carbon atoms and at least one heteroatom, where each heteroatom may be selected from N, O, and S. As used herein, a heteroaryl ring may be selected from monocyclic or bicyclic rings and fused or bridging ring systems, where at least one of the rings in the ring system is aromatic, i.e., it contains a cyclic delocalized (4n+2)π electron system according to Hückel's rule. The heteroatom in the heteroaryl radical may be oxidized as necessary. One or more nitrogen atoms, if present, may be quaternized as necessary. The heteroaryl may be attached to the remainder of the molecule through any atom of the heteroaryl, e.g., a carbon or nitrogen atom of the heteroaryl, where valency is acceptable. Examples of heteroaryls, but not limited to, include pyridine, pyrimidine, oxazole, furan, pyran, thiophene, isoxazole, benzimidazole, benzothiazole, and imidazopyridine.

[0044] "X-membered heteroaryl" refers to the number of ring atoms in the ring, i.e., X. For example, a 5-membered heteroaryl ring or 5-membered aromatic heterocycle has 5 ring atoms, such as triazole, oxazole, thiophene, etc.

[0045] The term "unsaturated heterocycle" refers to a heterocycle having at least one degree of unsaturation, excluding aromatic heterocycles. Examples of unsaturated heterocycles include dihydropyrrole, dihydrofuran, oxazoline, pyrazoline, and dihydropyridine. Heterocycles may be optionally substituted by one or more substituents, for example, substituents described herein.

[0046] The term “substituted” refers to a moiety having a substituent that replaces one or more carbons or substituteable heteroatoms of a structure, for example, hydrogens on an NH group. It will be understood that “substituted” or “substituted with” implies that such substitutions are subject to the acceptable valencies of the substituted atom and substituent, and that the substitution results in a stable compound, i.e., a compound that does not spontaneously undergo transformations, such as rearrangement, cyclization, or elimination. In certain embodiments, “substituted” refers to a moiety having a substituent that replaces two hydrogen atoms on the same carbon atom, for example, two hydrogen atoms on a single carbon atom replaced by an oxo, imino, or thioxo group.

[0047] As used herein, the term “substituted” is intended to include all permissible substituents of an organic compound. In broad embodiments, permissible substituents include acyclic and cyclic, branched and unbranched, carbocyclic and heterocyclic, aromatic and non-aromatic substituents of an organic compound. For a given organic compound, there may be one or more permissible substituents, and they may be the same or different. For the purposes of this disclosure, a heteroatom such as nitrogen may have a hydrogen substituent and / or any permissible substituent of the organic compound described herein that satisfies the valence of the heteroatom. In some embodiments, the substituent may be any substituent described herein, e.g., halogen, hydroxy, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=NH), oxymo (=N-OH), hydrazino (=N-NH2), -R b -OR a ,-R b -OC(O)-R a ,-R b -OC(O)-OR a ,-R b -OC(O)-N(R a )2, -R b -N(R a )2, -R b -C(O)R a ,-R b -C(O)OR a ,-R b-C(O)N(R a )2, -R b -O-R c -C(O)N(R a )2, -R b -N(R a )C(O)OR a , -R b -N(R a )C(O)R a , -R b -N(R a )S(O) t R a (where t is 1 or 2), -R b -S(O) t R a (where t is 1 or 2), -R b -S(O) t OR a (where t is 1 or 2), and -R b -S(O)<00故00913>N(R a )2(where t is 1 or 2); and may include alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, aralkynyl, cycloalkyl, cycloalkylalkyl, and heterocyclic ring, any of which may be alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo(=O), thioxo(=S), cyano(-CN), nitro(-NO2), imino(=N-H), oximo(=N-OH), hydrazine(=N-NH2), -R b -OR a , -R b -OC(O)-R a , -R b [[ID=已56]]-OC(O)-OR a , -R b -OC(O)-N(R a )2, -R b -N(R a )2, -R b -C(O)R a , -R b -C(O)OR a , -R b -C(O)N(R a )2, -R b -O-R c -C(O)N(Ra ) 2, -R b -N(R a )C(O)OR a 、-R b -N(R a )C(O)R a 、-R b -N(R a )S(O) t R a (where t is 1 or 2), -R b -S(O) t R a (where t is 1 or 2), -R b -S(O) t OR a (where t is 1 or 2) and -R b -S(O) t N(R a )2 (where t is 1 or 2) may be optionally substituted; each R a is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl, and each R a is, when the valence allows, alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo(=O), thioxo(=S), cyano(-CN), nitro(-NO2), imino(=N-H), oxime(=N-OH), hydrazine(=N-NH2), -R b -OR a 、-R b -OC(O)-R a 、-R b -OC(O)-OR a 、-R b -OC(O)-N(R a )2、-R b -N(R a )2、-R b -C(O)R a 、-R b -C(O)OR a 、-R b -C(O)N(R a )2、-R b -O-Rc -C(O)N(R a )2, -R b -N(R a )C(O)OR a ,-R b -N(R a )C(O)R a ,-R b -N(R a )S(O) t R a (In the formula, t is either 1 or 2), -R b -S(O) t R a (In the formula, t is either 1 or 2), -R b -S(O) t Ure a (wherein the formula t is 1 or 2) and -R b -S(O) t N(R a )2 (where t is 1 or 2) may be substituted as needed; each R b These are independently selected from directly bonded, linear, or branched alkylene, alkenylene, or alkynylene chains, and each R c These are linear or branched alkylene, alkenylene, or alkynylene chains.

[0048] Where used herein, the terms “as needed” or “as required” mean that the events of the situation described thereafter may or may not occur, and that the description includes examples of events or situations in which they may or may not occur. For example, “as needed substituted aryl” means that the aryl group may or may not be substituted, and that the description includes both substituted aryl groups and unsubstituted aryl groups.

[0049] As used herein, the terms “electrophile” or “electrophilic moiety” refer to any moiety that can react with a nucleophile (e.g., a moiety having a lone pair of electrons, a negative charge, a partially negative charge, and / or an excess of electrons, e.g., an -SH group). Electrophiles typically include electron-deficient or electron-deficient atoms. In certain embodiments, the electrophile is a moiety containing a positive charge or partially positive charge, having a resonance structure containing a positive charge or partially positive charge, or where electron delocalization or polarization results in one or more atoms containing a positive charge or partially positive charge. In some embodiments, the electrophile includes a conjugated double bond, e.g., an α,β-unsaturated carbonyl compound or an α,β-unsaturated thiocarbonyl compound.

[0050] As used herein and in the claims, the singular forms "a," "an," and "the" refer to multiple subjects unless the context explicitly indicates otherwise.

[0051] The terms “salt” or “pharmaceutically acceptable salt” refer to salts derived from various organic and inorganic counterions known in the art. Pharmaceutically acceptable acid addition salts can be formed with inorganic and organic acids. Examples of inorganic acids from which salts can be derived include hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, and phosphoric acid. Examples of organic acids from which salts can be derived include acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, and salicylic acid. Pharmaceutically acceptable base addition salts can be formed with inorganic and organic bases. Examples of inorganic bases from which salts can be derived include sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, and aluminum. Examples of organic bases from which salts can be derived include primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, and basic ion exchange resins, specifically, isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine. In some embodiments, pharmaceutically acceptable base addition salts are selected from salts of ammonium, potassium, sodium, calcium, and magnesium.

[0052] When used herein, the terms “parenteral administration” and “administered parenterally” mean, but are not limited to, methods of administration other than enteral and topical administration, usually by injection, including, but not limited to, intravenous, intramuscular, intra-arterial, subarachnoid, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subepidermal, intra-articular, subcapsular, subarachnoid, intraspinal, and intrasternal injections and infusions.

[0053] The term "pharmaceutically acceptable" is used herein to mean, within reasonable medical judgment, a compound, material, composition, and / or dosage form that is suitable for use in contact with human and animal tissues, without excessive toxicity, irritation, allergic response, or other problems or complications, and that is commensurate with a reasonable benefit / risk ratio.

[0054] When used herein, the terms “pharmaceutically acceptable additive” or “pharmaceutically acceptable carrier” mean a pharmaceutically acceptable material, composition or vehicle, e.g., a liquid or solid filler, diluent, excipient, solvent or encapsulating material. Each carrier must be “acceptable” in the sense that it is compatible with the other components of the formulation and is not harmful to the patient. Some examples of materials that can function as pharmaceutically acceptable carriers include: (1) sugars, e.g., lactose, glucose and sucrose; (2) starches, e.g., corn starch and potato starch; (3) cellulose and its derivatives, e.g., sodium carboxymethylcellulose, ethylcellulose and cellulose acetate; (4) tragacanth powder; (5) malt; (6) gelatin; (7) talc; (8) excipients, e.g., cocoa butter and suppository wax; (9) oils, e.g., peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil. (10) Glycols, e.g., propylene glycol; (11) Polyols, e.g., glycerin, sorbitol, mannitol, and polyethylene glycol; (12) Esters, e.g., ethyl oleate and ethyl laurate; (13) Agar; (14) Buffers, e.g., magnesium hydroxide and aluminum hydroxide; (15) Alginic acid; (16) Pyrogen-free water; (17) Isotonic saline; (18) Ringer's solution; (19) Ethyl alcohol; (20) Phosphate buffer; and (21) Other non-toxic suitable substances used in pharmaceutical formulations.

[0055] In certain embodiments, the terms “prevent” or “preventive” may refer to a compound that, when related to a disease or disorder, reduces the incidence of a disorder or condition in a treated sample compared to an untreated control sample, or delays the onset of one or more symptoms of a disorder or condition, or reduces its severity, compared to an untreated control sample.

[0056] The terms “to treat,” “to treat,” or “treatment” as used herein may include reducing, weakening, or alleviating the symptoms of a disease or condition; preventing additional symptoms; alleviating or preventing the underlying cause of the symptoms; inhibiting a disease or condition, for example, stopping the onset of a disease or condition; mitigating a disease or condition; causing regression of a disease or condition; alleviating a condition caused by a disease or condition; or stopping the symptoms of a disease or condition preventively and / or therapeutically.

[0057] As used herein, the term “G12 mutant” refers to another oncogenic allele of KRAS at amino acid position 12 (i.e., G12X). Compounds of the Disclosure

[0058] The following is a consideration of compounds and their salts that may be used in the methods of this disclosure.

[0059] In some embodiments, this disclosure relates to a compound of formula (I): [ka] or a pharmaceutically acceptable salt thereof [in the formula, R 100 teeth, [ka] Selected from; R 1A C 1~6 Alkyl, C3~C 12Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 11 Replaced as needed, R 1A Two R on the same atom 11 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 11A Each is replaced as needed; R 1B is hydrogen, C 1~6 Selected from alkyl, C3-C6 carbon rings, and 4-6 membered heterocycles, C 1~6 Alkyl, C3-C6 carbon rings, and 4-6 membered heterocycles are one or more R 10 Are they replaced as needed? Or R 1A and R 1B Together with the atoms they bond to, R 1 Forms R 1 It is a 5-15 member heterocycle, and 5-15 member heterocycles are halogens, -B(OR 20 )2, -N(R 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(=NR 20 )N(R 20 )2, -C 1~6 Alkyl (=NR) 20 Ure 20 ), -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , -C(O)OR20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl-SO2R 20 , C 1~6 Alkoxyalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Optionally substituted with one or more substituents independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles contain one or more R 1* They are independently replaced as needed; Each R 1* is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20-OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, and C3~C 12 Selected independently from the carbon ring; R 1C is hydrogen, C 1~6 Alkyl, C3~C 12 Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 12 Replaced as needed, R 1C Two R on the same atom 12 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 12A Each is replaced as needed; R 1D is hydrogen, C 1~6 Alkyl, C3~C 12 Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 13 Replaced as needed, R 1D Two R on the same atom 13 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 13A Each is replaced as needed; Y is -O-; R 2 is a heteroalgebra, -L-heteroalgebra, -LN(R 20 )2, -L-OR 20-L-aryl, -L-heteroaryl, -L-cycloalkyl, -L-NHC(=NH)NH2, -LC(O)N(R 20 )2, -L-C1~C6 haloalkyl, -L-NR 20 C(O)-aryl, -L-COOH, -L-NR 20 S(O)2(R 20 ), -LS(O)2N(R 20 )2, -LN(R 20 )C(O)(OR 20 ), -L-OC(O)N(R 20 )2, and selected from -LC(=O)OC1~C6 alkyl, the heterocycle, the heterocyclic moiety of the -L-heterocycle, and the cycloalkyl moiety of the -L-cycloalkyl are one or more R 6 These are replaced as needed, -L-NR 20 The aryl portion of C(O)-aryl, the aryl portion of -L-aryl, and the heteroaryl portion of -L-heteroaryl are one or more R 7 Each is replaced as needed; Each L stands for halogen, hydroxyl, and C. 1~6 Independently selected from C1-C4 alkylenes optionally substituted with one or more substituents independently selected from alkoxy, C1-C4 hydroxyalkyl, C1-C4 alkyl, C3-C6 carbon rings, and 3-8 membered heterocycles, wherein the C3-C6 carbon rings and 3-8 membered heterocycles are halogens, -OH, -NO2, =O, =S, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Each is optionally substituted with one or more substituents independently selected from the haloalkyl group; optionally, two substituents on the same carbon atom of L may combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, where the C3-C6 carbon ring and 3-8 membered heterocycle are halogen, -OH, -NO2, =O, =S, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C1~6 Alkoxy, C 1~6 Hydroxyalkyl, and C 1~6 Each substituent is optionally substituted with one or more substituents independently selected from the haloalkyl group; Each R 4 These are halogen, -NO2, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,=O,=S,-CN,C 1~6 Alkyl, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Cyanoalkyl, C 1~6 Hydroxyalkyl, and C 1~6 Independently selected from haloalkyl groups; n is selected from 0, 1, 2, 3, and 4; m is selected from 1 and 2; Each R 5 These are independently selected from hydrogen and C1-C6 alkyl groups; Each R 6 is halogen, hydroxy, C l ~C3 hydroxyalkyl, C1~C3 alkyl, oxo, C1~C3 haloalkyl, C1~C3 alkoxy, cyano, =CH2, =NO-C1~C3 alkyl, C1~C3 aminoalkyl, -N(R) 5 )S(O)2(R 5 ), -Q-phenyl, -Q-phenylSO2F, -NHC(O)phenyl, -NHC(O)phenylSO2F, C1~C3 alkyl-substituted pyrazolyl, tert-butyldimethylsilyloxyCH2-, -N(R 5 )2, (C1~C3 alkoxy)C1~C3 alkyl-, (C1~C3 alkyl)C(=O), oxo, (C1~C3 haloalkyl)C(=O)-, -SO2F, (C1~C3 alkoxy)C1~C3 alkoxy, -CH2OC(O)NCF3(R 5 ), -CH2O-C1~C6 alkyl, -CH2OC(O)N(R 5 )2,-CH2NHC(O)OC1~C6 alkyl,-CH2NHC(O)N(R 5)2, -CH2NHC(O)C1~C6 alkyl, -CH2(pyrazolyl), -CH2NHSO2C1~C6 alkyl, -CH2OC(O) heterocycle, -OC(O)N(R 5 )2,-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl),-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl)phenyl(C1~C3alkyl)N(CH3)2,-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl)phenyl,-OC(O)heterocycle,-O-C1~C3alkyl,-O-C1~C6 haloalkyl,-C1~C3alkyl-O-C1~C6 haloalkyl,C 1~6 alkyl-N(R 20 )2, -SF5, -C1~C3 alkyl-N3, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-(CH2) 0~1 S-heterogenetic algebra, -(CH2) 0~1 -O-heterogenetic ring, -(CH2) 0~1 -O-phenyl and -CH2 heterocycles are independently selected, The phenyl group in -NHC(O)phenyl and -OC(O)NH(C1~C3alkyl)(C1~C3alkyl)phenyl is optionally substituted with one or more substituents selected from -C(O)H and OH. -O-C1~C3 alkyl groups are optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups; The alkyl group of -CH2O-C1~C6 alkyl is optionally substituted with one or more substituents selected from halogens and C3~C6 carbon rings; The heterocycle of the -CH2 heterocycle is substituted with oxos as needed; -(CH2) 0~1 -O-phenyl is C 1~6 Alkyl, C 1~6 Haloalkyl, SF5, C 1~6 Alkyl-OR 20, -OR 20 Replaced as needed with one or more substituents selected from; -(CH2) 0~1 -O-heterogenetic rings and -(CH2) 0~1 The complex algebra of the -S- complex algebra is C 1~6 Alkyl, C 1~6 Haloalkyl, C 1~6 Alkyl-OR 20 , and -OR 20 Each of these substituents is optionally replaced by one or more substituents selected from the following; Each Q is selected from joins and O; Each R 7 These include halogens, hydroxyls, HC(=O)-, C1-C4 alkyls, C1-C4 alkoxys, C1-C4 haloalkyls, C1-C4 hydroxyalkyls, and -N(R) 5 ) Selected independently from 2; R 8 The 5- to 12-membered heterocycles are selected from halogens, -CN, -NO2, =O, -N(R) 20 )2, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -C(O)NR 20 -OR 20 , C 1~6 alkyl-N(R20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Substituting as necessary with one or more substituents independently selected from carbocyclic and 5- to 12-membered heterocycles; R 9 These are hydrogen, halogen, -CN, -NO2, -N(R) 20 )2, -OR 20 , -SR 20 , C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkynyl and selected from C3-C6 carbon rings, where the C3-C6 carbon ring contains one or more halogens, -CN, -NO2, -N(R) 20 )2, -OR 20 , -SR 20 , C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Is it substituted as needed with alkynyl; or R 8 and R 9These, together with the atoms they bond to, form B, which is a 7-15 membered heterocycle and C7-C 15 Selected from carbon rings, 7-15 membered heterocycles and C7-C 15 The carbon ring is a halogen, -CN, -NO2, =O, -N(R) 20 )2, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Each is optionally substituted with one or more substituents independently selected from the carbocyclic and 5- to 12-membered heterocycles; Each R 10 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20)2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles are halogens, -OH, -CN, -NO2, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Each substituent is optionally substituted with one or more substituents independently selected from alkyl and oxo; Each R 11 , R 12 , and R 13 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NR 20 (C=NH)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles are halogens, -OH, -CN, -NO2, -N(R) 21 )2, -SR 21 ,-C(O)N(R 21 )2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Alkyl, -S(O)2(R 21 ), -P(O)(OR 21 )2, -OP(O)(OR 21 )2, -P(O)(R 21 )2, and each as needed, substituted with one or more substituents independently selected from the oxo; Each R11A , R 12A , and R 13A is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Selected independently of Alkinnir; Each R 20 hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2, C 1~10 Alkyl, C 1~10 Haloalkyl, -OC 1~10 Alkyl, oxo, C 3~12C as needed, substituted with one or more substituents independently selected from carbocyclic and 3- to 12-membered heterocycles. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~12 Independently selected from carbon rings and 3- to 12-membered heterocycles; Each R 21 hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, -N(C) 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Alkyl, oxo, C 3~12 C as needed, substituted with one or more substituents independently selected from carbocyclic and 3- to 12-membered heterocycles. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~12 [Independently selected from carbon rings and 3- to 12-membered heterocycles] To provide.

[0060] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from; R 1A C 1~6 Alkyl, C3~C 12 Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 11 Replaced as needed, R 1A Two R on the same atom 11 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 11A Each is replaced as needed; R 1B is hydrogen, C 1~6 Selected from alkyl and C3-C6 carbon rings, C1~6 Alkyl and C3-C6 carbon rings are one or more R 10 Are they replaced as needed? Or R 1A and R 1B Together with the atoms they bond to, R 1 Forms R 1 It is a 5-15 member heterocycle, and 5-15 member heterocycles are halogens, -B(OR 20 )2, -N(R 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(=NR 20 )N(R 20 )2, -C 1~6 Alkyl (=NR) 20 Ure 20 ), -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6Alkyl-SO2R 20 , C 1~6 Alkoxyalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Optionally substituted with one or more substituents independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles contain one or more R 1* They are independently replaced as needed; Each R 1* is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C2~6 Alkenil, C 2~6 Alkinyl, and C3~C 12 Selected independently from the carbon ring; R 1C is hydrogen, C 1~6 Alkyl, C3~C 12 Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 12 Replaced as needed, R 1C Two R on the same atom 12 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 12A Each is replaced as needed; R 1D is hydrogen, C 1~6 Alkyl, C3~C 12 Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 13 Replaced as needed, R 1D Two R on the same atom 13 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 13A Each is replaced as needed; Y is -O-; R 2 is a heteroalgebra, -L-heteroalgebra, -LN(R 20 )2, -L-OR 20 -L-aryl, -L-heteroaryl, -L-cycloalkyl, -L-NHC(=NH)NH2, -LC(O)N(R 20 )2, -L-C1~C6 haloalkyl, -L-NR 20 C(O)-aryl, -L-COOH, -L-NR 20 S(O)2(R 20 ), -LS(O)2N(R 20 )2, -LN(R 20 )C(O)(OR 20 ), -L-OC(O)N(R 20)2, and selected from -LC(=O)OC1~C6 alkyl, the heterocycle, the heterocyclic moiety of the -L-heterocycle, and the cycloalkyl moiety of the -L-cycloalkyl are one or more R 6 These are replaced as needed, -L-NR 20 The aryl portion of C(O)-aryl, the aryl portion of -L-aryl, and the heteroaryl portion of -L-heteroaryl are one or more R 7 Each is replaced as needed; Each L stands for halogen, hydroxyl, and C. 1~6 Independently selected from C1-C4 alkylenes optionally substituted with one or more substituents independently selected from alkoxy, C1-C4 hydroxyalkyl, C1-C4 alkyl, C3-C6 carbon rings, and 3-8 membered heterocycles, wherein the C3-C6 carbon rings and 3-8 membered heterocycles are halogens, -OH, -NO2, =O, =S, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Each is optionally substituted with one or more substituents independently selected from the haloalkyl group; optionally, two substituents on the same carbon atom of L may combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, where the C3-C6 carbon ring and 3-8 membered heterocycle are halogen, -OH, -NO2, =O, =S, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, and C 1~6 Each substituent is optionally substituted with one or more substituents independently selected from the haloalkyl group; Each R 4 These are halogen, -NO2, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,=O,=S,-CN,C 1~6 Alkyl, C 1~6 Aminoalkyl, C 1~6Alkoxy, C 1~6 Cyanoalkyl, C 1~6 Hydroxyalkyl, and C 1~6 Independently selected from haloalkyl groups; n is selected from 0, 1, 2, 3, and 4; m is selected from 1 and 2; Each R 5 These are independently selected from hydrogen and C1-C6 alkyl groups; Each R 6 Halogen, hydroxy, C1-C3 hydroxyalkyl, C1-C3 alkyl, oxo, C1-C3 haloalkyl, C1-C3 alkoxy, cyano, =CH2, =NO-C1-C3 alkyl, C1-C3 aminoalkyl, -N(R) 5 )S(O)2(R 5 ), -Q-phenyl, -Q-phenylSO2F, -NHC(O)phenyl, -NHC(O)phenylSO2F, C1~C3 alkyl-substituted pyrazolyl, tert-butyldimethylsilyloxyCH2-, -N(R 5 )2, (C1~C3 alkoxy)C1~C3 alkyl-, (C1~C3 alkyl)C(=O), oxo, (C1~C3 haloalkyl)C(=O)-, -SO2F, (C1~C3 alkoxy)C1~C3 alkoxy, -CH2OC(O)N(R 5 )2,-CH2NHC(O)OC1~C6 alkyl,-CH2NHC(O)N(R 5 )2, -CH2NHC(O)C1~C6 alkyl, -CH2(pyrazolyl), -CH2NHSO2C1~C6 alkyl, -CH2OC(O) heterocycle, -OC(O)N(R 5 )2,-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl),-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl)phenyl(C1~C3alkyl)N(CH3)2,-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl)phenyl,-OC(O)heterocycle,-O-C1~C3alkyl,-S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20), -NR 20 S(O)2R 20 Independently selected from the -CH2 heterocycle, the phenyl in -NHC(O)phenyl and -OC(O)NH(C1~C3 alkyl)(C1~C3 alkyl)phenyl is optionally substituted with one or more substituents selected from -C(O)H and OH, the alkyl in -O-C1~C3 alkyl is optionally substituted with substituents selected from heterocycle, oxo and hydroxyl; the heterocycle of -CH2 heterocyclil is optionally substituted with oxo; Each Q is selected from joins and O; Each R 7 These include halogens, hydroxyls, HC(=O)-, C1-C4 alkyls, C1-C4 alkoxys, C1-C4 haloalkyls, C1-C4 hydroxyalkyls, and -N(R) 5 ) Selected independently from 2; R 8 The 5- to 12-membered heterocycles are selected from halogens, -CN, -NO2, =O, -N(R) 20 )2, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -C(O)NR 20 -OR 20 , C 1~6 alkyl-N(R 20)2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Substituting as necessary with one or more substituents independently selected from carbocyclic and 5- to 12-membered heterocycles; R 9 These are hydrogen, halogen, -CN, -NO2, -N(R) 20 )2, -OR 20 , -SR 20 , C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkynyl and selected from C3-C6 carbon rings, where the C3-C6 carbon ring contains one or more halogens, -CN, -NO2, -N(R) 20 )2, -OR 20 , -SR 20 , C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Is it substituted as needed with alkynyl; or R 8 and R 9 These, together with the atoms they bond to, form B, which is a 7-15 membered heterocycle and C7-C15 Selected from carbon rings, 7-15 membered heterocycles and C7-C 15 The carbon ring is a halogen, -CN, -NO2, =O, -N(R) 20 )2, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Each is optionally substituted with one or more substituents independently selected from the carbocyclic and 5- to 12-membered heterocycles; Each R 10 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles are halogens, -OH, -CN, -NO2, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Each substituent is optionally substituted with one or more substituents independently selected from alkyl and oxo; Each R 11 , R 12 , and R 13 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles are halogens, -OH, -CN, -NO2, -N(R) 21 )2, -C(O)N(R 21 )2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Each substituent is optionally substituted with one or more substituents independently selected from alkyl and oxo; Each R 11A , R 12A , and R 13A is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20(=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Selected independently of Alkinnir; Each R 20 hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Alkyl, oxo, C 3~12 C as needed, substituted with one or more substituents independently selected from carbocyclic and 3- to 12-membered heterocycles. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~12 Independently selected from carbon rings and 3- to 12-membered heterocycles; Each R 21 hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, -N(C) 1~6Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Alkyl, oxo, C 3~12 C as needed, substituted with one or more substituents independently selected from carbocyclic and 3- to 12-membered heterocycles. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~12 They are independently selected from carbon rings and 3- to 12-membered heterocycles.

[0061] In some embodiments, formula (I) is, [ka] or represented by a pharmaceutically acceptable salt thereof.

[0062] In some embodiments, formula (I) is, [ka] or represented by a pharmaceutically acceptable salt thereof.

[0063] In some embodiments, formula (I) is, [ka] or represented by a pharmaceutically acceptable salt thereof.

[0064] In some embodiments, formula (I) is, [ka] or represented by a pharmaceutically acceptable salt thereof.

[0065] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (ID), formula (IE), formula (IG), formula (IH), or formula (IJ), R 8 and R 9 These, together with the atoms they bond to, form B.

[0066] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), B is optionally substituted 7-15 membered condensed heterocycles and optionally substituted C7-C 15 Selected from condensed carbocyclic rings. In some cases, substituted C7~C as needed. 15 It is a condensed carbocyclic ring. In some cases, B is a 7-15 member condensed heterocycle as needed. In some cases, B is an unsaturated 7-15 member condensed heterocycle as needed. In some cases, B is a 7-15 member condensed heteroaryl as needed. In some cases, B is a 7-15 member condensed heteroaryl as needed and a C7-C as needed. 15 Selected from condensed aryls. In some cases, B is replaced as needed with unsaturated C7-C. 15 It is a condensed carbocyclic ring. In some cases, B is a 7-15 member condensed heterocyclic ring that is substituted as needed, and the condensed heterocyclic ring is partially unsaturated. In some cases, B is a 7-15 member condensed heterocyclic ring that is substituted as needed, and the condensed heterocyclic ring is partially saturated.

[0067] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), B is optionally substituted 8-15 membered condensed heterocycles and optionally substituted C8-C 15 Selected from condensed carbocyclic rings. In some cases, substituted C8~C as needed. 15 It is a condensed carbon ring. In some cases, B is an 8-15 member condensed heterocycle, substituted as needed. In some cases, B is an unsaturated 8-15 member condensed heterocycle, substituted as needed. In some cases, B is an unsaturated C8-C 15It is a condensed carbocyclic ring. In some cases, B is an 8-15 member condensed heterocyclic ring that is substituted as needed, and the condensed heterocyclic ring is partially unsaturated. In some cases, B is an 8-15 member condensed heterocyclic ring that is substituted as needed, and the condensed heterocyclic ring is partially saturated.

[0068] In some embodiments, for compounds or salts of formula (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (II), or (IJ), B is selected from optionally substituted 8-15 membered condensed heterocycles, the condensed heterocycle being formed by joining three rings (e.g., tricyclic). In some cases, B is selected from optionally substituted 8-15 membered condensed heterocycles, the condensed heterocycle being formed by joining two rings (e.g., bicyclic). In some cases, B is an optionally substituted 8-15 membered condensed heterocycle and optionally substituted C8-C 15 Each fused carbocyclic ring is independently bicyclic or tricyclic. In some cases, the 8-15 member fused heterocyclic ring, with B substituted as needed, is bicyclic. In some cases, the 8-15 member fused heterocyclic ring, with B substituted as needed, is tricyclic.

[0069] In some embodiments, for compounds or salts of formula (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (II), or (IJ), the heterocycle or carbocycle of B is bicyclic. In some cases, the heterocycle or carbocycle of B is tricyclic. In some cases, the tricyclic heterocycle contains three interconnected atomic rings.

[0070] In some embodiments, for compounds or salts of formula (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (II), or (IJ), the heterocycle and carbocycle of B are independently selected from bicyclic and tricyclic structures, respectively. In some cases, the heterocycle and carbocycle of B are independently tricyclic. In some cases, the heterocycle and carbocycle of B are independently bicyclic.

[0071] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), B is optionally substituted with an 8-15 membered condensed heterocycle and optionally substituted with C8-C 15 Condensed carbocyclic rings are [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, for B, optionally substituted 8-15 membered condensed heterocycles and optionally substituted C8-C 15 Condensed carbocyclic rings are [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, B is [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, B is [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, B is [ka] Selected from these, each of which is optionally replaced with one or more substituents.

[0072] In some embodiments, with respect to a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), B is: [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, B is [ka] A selection is made from the following, each of which is optionally substituted with one or more substituents. In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), B is optionally substituted 8- to 15-membered condensed heterocycle, and B contains at least one heteroatom selected from nitrogen, sulfur, and selenium. In some cases, B is optionally substituted 8- to 15-membered condensed heterocycle, and B contains at least one heteroatom selected from nitrogen and selenium. In some cases, B is optionally substituted 8- to 15-membered condensed heterocycle, and B contains at least one heteroatom selected from selenium. In some cases, B is optionally substituted 8- to 15-membered condensed heterocycle, and B contains at least one heteroatom selected from sulfur and selenium. In some cases, B is an optionally substituted 8- to 10-membered condensed heterocycle, and B contains at least one heteroatom selected from nitrogen, sulfur, and selenium. In some cases, B is an optionally substituted 8-membered condensed heterocycle, and B contains at least one heteroatom selected from nitrogen, sulfur, and selenium.

[0073] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), for B, the substituents on the heterocycle and carbocyclic ring as needed are halogen, -CN, -NO2, =O, -N(R 20 )2, -B(OR 20 )2, -OR 20 , -SR 20 , C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 The carbon ring and the 5- to 12-membered heterocycle are selected independently. In some cases, the substituents on the heterocycle and carbon ring as needed are halogens, -CN, -NO2, =O, -N(R) 20 )2, -B(OR 20 )2, -OH, -SR 20 , C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each is independently selected from the alkynyl group. In some cases, for B, one or more substituents as needed on the heterocycle and carbocyclic ring are, in their respective appearances, halogen, oxo, -NH2, C1~C3 alkyl, -B(OH)2, -OH, -O-C1~C3 haloalkyl, -C(O)NH2, -NH2, =O, -CN, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, and C 2~6The substituents are selected independently of the alkynyl group. In some cases, the substituents required for heterocyclic and carbocyclic rings are halogen, -CN, =O, -NH2, -N(C) 1~6 Alkyl)H-N(C 1~6 Alkyl)2,-OH,C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each is independently selected from alkynyls. In some cases, one or more optional substituents on the heterocycle and carbocyclic ring are independently selected from oxo, -NH2, halogen, and C1-C3 alkyl groups. In some cases, B is optionally substituted 8-15 membered condensed heterocycles and optionally substituted C8-C3 alkyl groups. 15 Condensed carbocyclic rings are [ka] Selected from. In some cases, B is [ka] [ka] Selected from. In some cases, B is [ka] [ka] Selected from. In some cases, B is [ka] Selected from.

[0074] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), B is optionally substituted 7-12 membered condensed heterocycles and optionally substituted C 9~10 Selected from fused carbocyclic rings. In some cases, the heterocycle of B has at least one sulfur atom. In some cases, the heterocycle of B has one sulfur atom. In some cases, the heterocycle of B has at least one nitrogen atom. In some cases, B is [ka] Selected from, each of these is substituted as needed. In some cases, one or more substituents of B as needed are halogens, C1-C3 alkyls, -B(OR 20 )2, -OR 20 ,-C(O)N(R 20 )2, -N(R 20 )2, =O, -CN, -NHCN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 2~6 Alkenyl and C 2~6 It is independently selected from alkynyl groups. In some cases, one or more optional substituents of B are independently selected from halogens, C1-C3 alkyl groups, -OH, -NH2, =O, and -CN groups, in their respective appearances. In some cases, B is, [ka] Selected from.

[0075] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), B is selected from optionally substituted 8-10 membered condensed heterocycles having at least one sulfur atom. In some cases, B is [ka] Selected from, each of which is substituted as necessary. In some cases, one or more substituents of B as necessary are halogen, C1-C3 alkyl, -OR 20 ,-C(O)N(R 20 )2, -N(R 20 )2, =O, -CN, -NHCN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 2~6 Alkenyl and C 2~6 It is independently selected from alkynyl groups. In some cases, one or more optional substituents of B are independently selected from halogens, C1-C3 alkyl groups, -NH2 groups, and -CN groups, in their respective appearances. In some cases, B is substituted. In some cases, B is substituted with at least one -NH2 group. In some cases, B is, [ka] Selected from. In some cases, B is replaced with at least one -NH2 and at least one -CN. In some cases, B is, [ka] Selected from.

[0076] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), B is a optionally substituted 7-11 membered condensed heterocycle. In some cases, B is an optionally substituted 8-10 membered condensed heterocycle. In some cases, the heterocycle of B is an unsaturated heterocycle. In some cases, the heterocycle of B is a non-aromatic heterocycle. In some cases, B has at least one sulfur atom. In some cases, B has two sulfur atoms. In some cases, B has at least one sulfur atom and at least one nitrogen atom. In some cases, B has at least one sulfur atom and at least one oxygen atom. In some cases, B has only one heteroatom. In some cases, B has at least two heteroatoms. In some cases, B is [ka] Selected from, each of which is replaced as necessary. In some cases, B is [ka] Selected from, each of which is replaced as necessary. In some cases, B is [ka] Selected from, each of which is substituted as necessary. In some cases, one or more substituents of B as necessary are, in their respective appearances, halogen, oxo, -NH2, C1~C3 alkyl, -B(OH)2, -OH, -O-C1~C3 haloalkyl, -C(O)NH2, -NH2, =O, -CN, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, and C 2~6It is independently selected from alkynyls. In some cases, one or more optional substituents of B are independently selected from halogens, C1-C3 alkyls, -NH2, and -CN, in their respective appearances. In some cases, B is substituted with at least one substituent selected from halogens, C1-C3 alkyls, -NH2, and -CN. In some cases, B is substituted with at least one substituent selected from halogens. In some cases, B is substituted with at least one substituent selected from -NH2. In some cases, B is substituted with at least one substituent selected from CN. In some cases, B is substituted with at least one substituent. In some cases, B is, [ka] Selected from.

[0077] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (ID), formula (IE), formula (IH), or formula (IJ), each R 9 Hydrogen, halogen, -CN, -N(R) 20 )2, -OR 20 , C 1~6 Aminoalkyl, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Selected from alkyl and C3-C6 cycloalkyl, where C3-C6 cycloalkyl is one or more halogens, -CN, -NO2, -N(R) 20 )2, -OR 20 , -SR 20 , C 1~6 Aminoalkyl, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Alkyl substitutions are used as needed. In some cases, each R 9is hydrogen, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Selected from alkyl and C3-C6 cycloalkyl, where C3-C6 cycloalkyl is one or more halogens, -CN, -NO2, -N(R) 20 )2, -OR 20 , -SR 20 , C 1~6 Aminoalkyl, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Alkyl substitutions are used as needed. In some cases, each R 9 is halogen, hydrogen, C 1~6 Selected from alkyl and C3-C6 cycloalkyl groups. In some cases, each R 9 is hydrogen, C 1~6 Selected from alkyl and C3-C6 cycloalkyl groups. In some cases, each R 9 R is selected from hydrogen, fluorine, methyl, and cyclopropyl. In some cases, each R 9 The element is selected from hydrogen, methyl, and cyclopropyl.

[0078] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (ID), formula (IE), formula (IH), or formula (IJ), R 8 It is selected from 5-6 member heteroaryls as needed. In some cases, R 8 It is selected from substituted 5-membered heteroaryls as needed. In some cases, R 8 The heteroaryl has at least one heteroatom selected from oxygen, nitrogen, and sulfur. In some cases, R 8 The heteroaryl contains only one sulfur atom. In some cases, R8 The heteroaryl group has at least one sulfur atom. In some cases, R 8 The heteroaryl group has at most one sulfur atom. In some cases, R 8 The heteroaryl group has at least one oxygen atom. In some cases, R 8 The heteroaryl has at least one nitrogen atom. In some cases, R 8 The heteroaryl is, [ka] And this is replaced as needed. In some cases, R 8 The heteroaryl is, [ka] And this is replaced as needed. In some cases, R 8 The heteroaryl is, [ka] And this is replaced. In some cases, R 8 One or more substituents as needed may be halogens, C 1~6 Alkyl, C 1~6 Haloalkyl, -N(R) 20 )2, and -CN are selected independently. In some cases, R 8 One or more substituents as needed may be halogens, -N(R 20 )2, and -CN are selected independently. In some cases, R 8 One or more substituents as needed are selected independently from halogens, -NH2, and -CN. In some cases, R 8 One or more substituents are independently selected from halogens, -NH2, and -CN. In some cases, R 8 One or more substituents as needed are selected independently from chlorine, -NH2, and -CN. In some cases, R 8 teeth, [ka] Selected from. In some cases, R 8 teeth, [ka] Selected from. In some cases, R 8 teeth, [ka] In some cases, R 8 teeth, [ka] That is the case.

[0079] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (ID), formula (IE), formula (IH), or formula (IJ), R 8 It is selected from 6- to 9-membered heteroaryls as needed. In some cases, R 8 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 8 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 8 One or more substituents as needed may be halogens, C 1~6 Alkyl, C 1~6 Haloalkyl, -N(R) 20 )2, and -CN are selected independently. In some cases, R 8 One or more substituents as needed may be halogens, C 2~6 Alkyl, C 1~6 Haloalkyl, -N(R) 20)2, and -CN are selected independently. In some cases, R 8 One or more substituents as needed may be halogens, C 1~6 Haloalkyl, -N(R) 20 )2, and -CN are selected independently. In some cases, R 8 teeth, [ka] Selected from. In some cases, R 8 The heteroaryl group has at least one sulfur atom. In some cases, R 8 The heteroaryl is bicyclic. In some cases, R 8 The heteroaryl is monocyclic. In some cases, R 8 teeth, [ka] And this is replaced as needed. In some cases, R 8 teeth, [ka] And this is replaced as needed. In some cases, R 8 One or more substituents as needed may be halogens, C 1~6 Alkyl, C 1~6 Haloalkyl, -N(R) 20 )2, and -CN are selected independently. In some cases, R 8 teeth, [ka] That is the case.

[0080] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (ID), formula (IE), formula (IH), or formula (IJ), R 8 It is selected from 5- to 12-membered unsaturated hetero rings as needed. In some cases, R 8It is selected from 8- to 12-membered unsaturated bicyclic heteroalgebras as needed. In some cases, R 8 It is selected from the 9-membered unsaturated hetero rings as needed. In some cases, R 8 The heterocycle of is a bicyclic heterocycle. In some cases, a bicyclic heterocycle has two rings. In some cases, one ring of the bicyclic heterocycle is an unsaturated carbon ring, and the second ring is a heteroaryl. In some cases, R 8 The heterocycle has at least one sulfur atom. In some cases, R 8 The complex ring of is [ka] And this is replaced as needed. In some cases, R 8 One or more substituents as needed may be halogens, -N(R 20 )2, and -CN are selected independently. In some cases, R 8 teeth, [ka] That is the case.

[0081] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), n is selected from 0 and 1. In some cases, n is 1. In some cases, n is 0. In some cases, n is 3. In some cases, n is 2.

[0082] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), each R 4 These are halogen, -NO2, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,=O,-CN,C1~6 Alkyl, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Cyanoalkyl, C 1~6 Hydroxyalkyl, and C 1~6 Selected independently from haloalkyl groups. In some cases, each R 4 This is chosen independently of =O.

[0083] In some embodiments, for the compound or salt of formula (I), m is 1. In some cases, m is 2. In some cases, R 8 and R 9 However, when they bond together with the atoms to form B, m is 1. In some cases, R 8 and R 9 However, when they combine with the atoms they bond to to form B, m is 2.

[0084] In some embodiments, for a compound or salt of formula (I), R 100 R 1 That is the case.

[0085] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from. In some cases, R 100 teeth, [ka] That is the case.

[0086] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from, R 1A C 1~6 Selected from alkyl groups, C 1~6Alkyl is one or more R 11 Replaced as needed, R 1A Two R on the same atom 11 These combine to form a C3-C6 carbon ring, and the C3-C6 carbon ring has one or more R 11A It is replaced as needed; or R 1A and R 1B Together with the atoms they bond to, R 1 Forms R 1 R is a 6- to 10-membered heterocycle with substitutions as needed; 1B is hydrogen and C 1~6 Selected from alkyl; R 1C C 1~6 Selected from alkyl groups, C 1~6 Alkyl is one or more R 12 Replaced as needed, R 1C Two R on the same atom 12 These combine to form a C3-C6 carbon ring, and the C3-C6 carbon ring has one or more R 12A It is replaced as needed.

[0087] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] (In the formula, R 1A C 1~6 Selected from alkyl groups, C 1~6 Alkyl is one or more R 11 Replaced as needed, R 1A Two R on the same atom 11 They combine to form an unsubstituted C3 carbon ring. [ka] (In the formula, R 1C C 1~6 Selected from alkyl groups, C 1~6 Alkyl is one or more R 12Replaced as needed, R 1C Two R on the same atom 12 They combine to form an unsubstituted C3 carbon ring; and [ka] (In the formula, R 1A and R 1B Together with the atoms they bond to, R 1 Forms R 1 teeth, [ka] Selected from (each of which is replaced as needed).

[0088] In some embodiments, for a compound or salt of formula (I), each R 11 It is selected from -CN, and R if necessary. 1A Two R on the same atom 11 Together, they form an unsubstituted C3 carbon ring; each R 12 It is selected from -CN, and R if necessary. 1C Two R on the same atom 12 They combine to form an unsubstituted C3 carbon ring; R 1 One or more substituents are halogens, -OR 20 ,-CN, oxo, C 1~6 Alkyl, C 1~6 Hydroxyalkyl and -C(O)N(R 20 ) Selected independently from 2.

[0089] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), each R 11 It is selected from -CN, and R if necessary. 1A Two R on the same atom 11 Together, they form an unsubstituted C3 carbon ring.

[0090] In some embodiments, for a compound or salt of formula (I), R 1 One or more substituents are halogens, -OR 20 ,-CN, oxo, C 1~6 Alkyl, C 1~6 Hydroxyalkyl and -C(O)N(R 20 )2 is selected independently. In some cases, R 1 One or more substituents are halogen, -OH, -CN, oxo, C 1~6 Alkyl, C 1~6 It is independently selected from hydroxyalkyl and -C(O)N(CH3)2.

[0091] In some embodiments, for compounds or salts of formula (I), formula (ID), formula (IE), or formula (IF), each R 12 It is selected from -CN, and R if necessary. 1C Two R on the same atom 12 Together, they form an unsubstituted C3 carbon ring.

[0092] In some embodiments, for a compound or salt of formula (I), R 1A teeth, [ka] Selected from; R 1C teeth, [ka] Selected from; R 1 One or more substituents are halogen, -OH, -CN, oxo, C 1~6 Alkyl, C 1~6 It is independently selected from hydroxyalkyl and -C(O)N(CH3)2.

[0093] In some embodiments, for a compound or salt of formula (I), R 1A teeth, [ka] Selected from; R1C teeth, [ka] Selected from; R 1 One or more substituents are halogen, -OH, -CN, oxo, C 1~6 Alkyl, C 1~6 It is independently selected from hydroxyalkyl and -C(O)N(CH3)2.

[0094] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1A teeth, [ka] Selected from.

[0095] In some embodiments, for a compound or salt of formula (I), formula (ID), formula (IE), or formula (IF), R 1C teeth, [ka] Selected from.

[0096] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from. In some cases R 100 teeth, [ka] Selected from.

[0097] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from.

[0098] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from, R 1A and R 1B Together with the atoms they bond to, R 1 It forms.

[0099] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from.

[0100] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from. In some cases, R 1A C 1~6 Alkyl, C3~C 12 Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 11 Replaced as needed, R 1A Two R on the same atom 11 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 11A Each is replaced as needed.

[0101] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1B It is hydrogen. In some cases, R 1B C is replaced as needed. 1~6 Selected from alkyl groups. In some cases, R 1BThese are selected from substituted C3-C6 carbon rings as needed.

[0102] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1A C is replaced as needed. 1~6 Selected from alkyl groups. In some cases, R 11 is -N(R 20 )2. In some cases, R 1A teeth, [ka] Selected from.

[0103] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1A It is a C4-C6 carbon ring, and the C4-C6 carbon ring has one or more R 11 It has as needed. In some cases, each R 11 is -N(R 20 ) Selected from 2, each R 20 This is hydrogen and, if necessary, substituted C 1~6 Selected from alkyl groups. In some cases, R 1A teeth, [ka] Selected from.

[0104] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1A The R is selected from 4- to 12-membered hetero rings, and the 4- to 12-membered hetero ring is one or more R 11 It has as needed. In some cases, each R 11 Halogen, -N(R 20 )2, -C(O)R 20 ,-C(O)N(R 20 )2, C 1~6Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected from alkyl groups. In some cases, R 1A teeth, [ka] Selected from. In some cases, R 1A The R is selected from 5-6 membered hetero rings, and the 5-6 membered hetero ring is one or more R 11 It has as needed. In some cases, the heterocycle has at least one oxygen atom. In some cases, the heterocycle has one oxygen atom. In some cases, R 1A teeth, [ka] Selected from, which is replaced as needed. In some cases, each R 11 is -OH and C 1~6 Selected from hydroxyalkyl groups. In some cases, each R 11 It is -OH. In some cases, R 1A teeth, [ka] Selected from.

[0105] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), each R 11A is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is selected independently of alkinil.

[0106] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), each R 11 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 The carbon rings and 5- to 12-membered heterocycles are selected independently. In some cases, each R is selected. 11 is halogen, -OR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 The carbon rings and 5- to 12-membered heterocycles are selected independently. In some cases, each R is selected. 11 is halogen, -OR 20 , -N(R 20 )2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 The carbon rings and 5- to 12-membered heterocycles are selected independently. In some cases, each R is selected. 11 is halogen, -OR 20 , -N(R 20 )2, -CN, -NHCN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, and C 1~6 It is independently selected from haloalkyl groups.

[0107] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1B C is hydrogen, and C is substituted as needed. 1~6 Selected from alkyl groups and, if necessary, substituted C3-C6 carbon rings. In some cases, R 1B is hydrogen, C 1~6 Alkyl, C 1~6 Cyanoalkyl, C 1~6 It is a hydroxyalkyl and C3-C6 carbon ring. In some cases, R 1BThese are hydrogen, methyl, ethyl, C2 hydroxyalkyl, and cyclopropyl. In some cases, R 1B It is hydrogen. In some cases, R 1B C is replaced as needed. 1~6 Selected from alkyl groups. In some cases, R 1B It is selected from methyl and ethyl. In some cases, R 1B It is methyl. In some cases, R 1B The C3-C6 carbon rings are selected as needed, substituted as necessary. In some cases, R 1B teeth, [ka] And in some cases, R 1B C 1~6 Selected from cyanoalkyls. In some cases, R 1B C 1~6 Selected from hydroxyalkyl groups.

[0108] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1A C is replaced as needed. 1~3 Selected from alkyl groups, and R as needed. 1A Two R on the same atom 11 They combine to form a C3 carbon ring. In some cases, R 11 Halogen, -N(R 20 )2, C3 carbon rings, and 5-6 membered heterocycles are selected, and the 5-6 membered heterocycles are halogens, -OH, -CN, -N(R 21 )2, C 1~10 Alkyl and -C 1~10 They are optionally substituted with one or more substituents independently selected from the haloalkyl group. In some cases, each R 21 is hydrogen; and C 1~6 Selected independently of alkyl, C 1~6 Alkyls are halogens, oxo, and C 3~6The carbon ring and / or 3- to 6-membered heterocycles are optionally substituted with one or more substituents independently selected from these rings.

[0109] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1A teeth, [ka] [ka] Selected from.

[0110] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] [ka] Selected from.

[0111] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1A C is replaced as needed. 1~6 Selected from alkyl groups. In some cases, R 1A C is replaced as needed. 1~3 Selected from alkyl groups, and R as needed. 1A Two R on the same atom 11 They combine to form a C3 carbon ring. In some cases, R 1A C is replaced as needed. 1~2 Selected from alkyl groups. In some cases, R 1A teeth, [ka] Selected from. In some cases, R 1A teeth, [ka] Selected from. In some cases, R 1A teeth, [ka] Selected from. In some cases, R 11 It is selected from 5- to 12-membered heterorings as needed. In some cases, R 11 It is selected from 5- to 8-membered heterorings as needed. In some cases, R 11 It is selected from substituted 5-6 member complex rings as needed. In some cases, R 11 The heteroaryl group is selected from substituted 5-6 membered heteroaryl groups as needed. In some cases, the heterocycle has at least one nitrogen atom. In some cases, the heterocycle has at least two nitrogen atoms. In some cases, the heteroaryl group has at least one nitrogen atom. In some cases, the heteroaryl group has at least two nitrogen atoms. In some cases, the heterocycle has only one nitrogen atom and no other heteroatoms. In some cases, the heterocycle has only two nitrogen atoms and no other heteroatoms. In some cases, R 11 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 11 teeth, [ka] Selected from, which is replaced as needed. In some cases, R 11 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 11 teeth, [ka] Selected from, each of which is substituted as needed. In some cases, one or more substituents as needed are halogens, -OH, -CN, -N(R) 21 )2, -C(O)N(R 21 )2, C 1~10 Alkyl and -C 1~10 Selected independently from haloalkyl groups. In some cases, R 21 is hydrogen; and C 1~6 Selected independently of alkyl, C 1~6 Alkyls are halogens, oxo, and C 3~6 The carbon ring and one or more substituents, independently selected from 3- to 6-membered heterocycles, are optionally substituted. In some cases, R 11 One or more substituents as needed may be halogens, C 1~6 Haloalkyl, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl) 2, [ka] , and C 1~10 Selected from alkyl groups. In some cases, R 11 One or more substituents as needed may be -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2, and C 1~10 Selected from alkyl groups. In some cases, R 11 One or more substituents as needed are -NH2 and C 1~10 Selected from alkyl groups. In some cases, R 11 One or more substituents are selected from -NH2 as needed. In some cases, R 11 teeth, [ka] Selected from. In some cases, R 1A teeth, [ka] Selected from. In some cases, R 1A teeth, [ka] Selected from. In some cases, R 1A teeth, [ka] That is the case.

[0112] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 100 teeth, [ka] Selected from.

[0113] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] [ka] Selected from. In some cases, R 100 teeth, [ka] Selected from. In some cases, R 100 teeth, [ka] Selected from. In some cases, R 100 teeth, [ka] Selected from.

[0114] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] [ka] Selected from. In some cases, R 1B is hydrogen, C 1~6 Alkyl, C 1~6 Hydroxyalkyl, and C 1~6 Selected from cyanoalkyls. In some cases, R 1B is hydrogen and C 1~6 Selected from alkyl groups. In some cases, R 1B C 1~6 Selected from alkyl groups. In some cases, R 1B It is cyclopropyl. In some cases, R 1B It is methyl. In some cases, R 1B It is ethyl. In some cases, R 100 teeth, [ka] Selected from. In some cases, R 100 teeth, [ka] [ka] Selected from. In some cases, R 100 teeth, [ka] Selected from. In some cases, R 100 teeth, [ka] Selected from.

[0115] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), and formula (IC), R 1A C 1~3Selected from alkyl groups, this is one or more R 11 It is replaced as needed, and each R 11 The carbon rings are selected from C3-C6 carbon rings and 5-6 membered heterocycles, and the 5-6 membered heterocycles and C3-C6 carbon rings are substituted as needed. In some cases, R 1A C 1~3 Selected from alkyl groups, this is one or more R 11 Replaced by each R 11 R is selected from phenyl and a 5-6 membered heterocycle, and the 5-6 membered heterocycle and phenyl are substituted as needed. In some cases, 11 It is phenyl, which is substituted as needed. In some cases, R 11 It is selected from 5-6 member heterorings, which are substituted as needed. In some cases, R 11 It is pyridine, which is substituted as needed. In some cases, R 1A teeth, [ka] Selected from. In some cases, R 1A teeth, [ka] In some cases, the heterocycle is a heteroaryl compound. In some cases, one or more substituents are halogens, -P(O)(R 21 )2, -OH, -CN, -N(R 21 )2, -C(O)N(R 21 )2, C 1~10 Alkyl and -C 1~10 Selected independently from haloalkyls. In some cases, one or more substituents are -P(O)(R 21 )2, -N(R 21 )2, and C 1~10 Selected independently of alkyl. In some cases, one or more substituents are -P(O)(R 21 )2, and -N(R 21)2 is selected independently. In some cases, one or more substituents are -P(O)(R 21 )2 is selected independently. In some cases, each R 21 is hydrogen and C 1~6 Selected independently of alkyl. In some cases, each R 21 C 1~3 Selected independently of alkyl. In some cases, R 100 or [ka] teeth, [ka] [ka] Selected from. In some cases, R 100 teeth, [ka] In some cases, R 100 or [ka] teeth, [ka] Selected from.

[0116] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from. In some cases, R 100 teeth, [ka] Selected from. In some cases, R 1B is hydrogen and C 1~6Selected from alkyl groups. In some cases, R 100 It is selected from. In some cases, R 100 teeth, [ka] In some cases, R 100 teeth, [ka] In some cases, R 100 teeth, [ka] In some cases, R 100 teeth, [ka] Selected from: In some cases, B is selected from 8- to 10-membered heterocycles, which include halogens, -CN, -NH2, and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, B is selected from an 8-membered heterocycle, which can be halogen, -CN, -NH2, and C 1~6 It is substituted with one or more substituents independently selected from the alkyl group. In some cases, the heterocycle of B has one sulfur atom and no other heteroatoms. In some cases, the heterocycle of B is an unsaturated heterocycle. In some cases, B is [ka] Selected from, each of which is replaced as necessary. In some cases, B is [ka] Selected from, each of which is substituted with at least one substituent. In some cases, B is [ka] Selected from. In some cases, B is [ka] In some cases, Y is O. In some cases, L is selected from C1-C4 alkylenes. In some cases, L is selected from unsubstituted C1-C4 alkylenes. In some cases, L is selected from unsubstituted C1 alkylenes. In some cases, two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and 3-8 membered heterocycle are halogen, -OH, -NO2, =O, =S, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Each L is optionally substituted with one or more substituents independently selected from the haloalkyl group. In some cases, two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle. In some cases, two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring. In some cases, each L is, [ka] Selected from. In some cases, R 2 It is selected from the substituted -L-heterogenes as needed. In some cases, R 2 The hetero ring is selected from the substituted -L-heterogenetic rings as needed, and the hetero ring is a saturated hetero ring. In some cases, the hetero ring is [ka] Selected from, each of these is one or more R 6 It is replaced as needed. In some cases, each R 6 These are halogens, hydroxyls, C1-C3 alkyls, C1-C3 haloalkyls, and -N(R) 5 )S(O)2(R 5 ), -OC(O)N(R 5)2, =CH2, oxo, =NO-C1~C3 alkyl, -CH2OC(O) heterocycle, -CH2 heterocycle, -CH2OC(O)N(R 5 )2, and are independently selected from -O-C1~C3 alkyl groups, where the alkyl group of the -O-C1~C3 alkyl group is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups. In some cases, each R 6 The R is independently selected from halogens, C1-C3 alkyls, and C1-C3 haloalkyls. In some cases, each R 6 It is selected independently of halogen. In some cases, YR 2 teeth, [ka] Selected from. In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] That is the case.

[0117] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), [ka] Regarding R 1A C 1~6 Selected from alkyl groups, this is one R 11 Replaced with one R 11 The 5-6 member heteroaryl compounds are selected as needed, and the 5-6 member heteroaryl compounds are substituted as needed; R 1B C is hydrogen, and C is substituted as needed. 1~6 Selected from alkyl and C3-C6 carbon rings, Or R1A and R 1B Together with the atoms they bond to, R 1 Forms R 1 It is selected from 5- to 10-membered complex rings as needed. In some cases, [ka] Regarding R 1A C 1~6 Selected from alkyl groups, this is one R 11 Replaced with one R 11 The 5-6 member heteroaryl compounds are selected as needed from substituted 5-6 member heteroaryl compounds, which include halogens, -OH, -CN, and -N(R) 21 )2, C 1~10 Alkyl and -C 1~10 Optionally substituted with one or more substituents independently selected from the haloalkyl group; R 1B is hydrogen, C 1~6 Alkyl, C 1~6 Cyanoalkyl, C 1~6 Selected from hydroxyalkyl and C3-C6 carbon rings, Or R 1A and R 1B Together with the atoms they bond to, R 1 Forms R 1 The 5- to 9-membered heterocycles are selected as needed, and these 5- to 9-membered heterocycles include -OH, -CN, oxo, -NHCN, and C. 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary; R 1AC is substituted with a 6-membered heteroaryl (e.g., pyridine, pyrimidine) as needed. 1~3 Selected from alkyl groups. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 teeth, [ka] Selected from, which is replaced as needed. In some cases, R 1 teeth, [ka] Selected from, which is replaced as needed. In some cases, R 1 teeth, [ka] Selected from, which is replaced as needed. In some cases, R 1 teeth, [ka] Selected from, which is replaced as needed. In some cases, R 1 teeth, [ka] Selected from, which is replaced as needed. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 One or more substituents as needed may be -OH, oxo, -CN, -NHCN, C 1~6 Hydroxyalkyl, C 1~6Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 It is selected independently of alkyl.

[0118] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from.

[0119] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] [ka] Selected from. In some cases, R 100 teeth, [ka] Selected from.

[0120] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] That is the case.

[0121] In some embodiments, formula (I) is, [ka] or represented by a pharmaceutically acceptable salt thereof.

[0122] In some embodiments, formula (I) is, [ka] or represented by a pharmaceutically acceptable salt thereof.

[0123] In some embodiments, formula (I) is, [ka] or represented by a pharmaceutically acceptable salt thereof.

[0124] In some embodiments, for a compound or salt of formula (I), formula (ID), formula (IE), or formula (IF), R 1C C is replaced as needed. 1~6 Selected from alkyl groups. In some cases, R 1C C is replaced as needed. 1~6 Selected from alkyl groups, and R as needed. 1C Two R on the same atom 12 These combine to form a C3-C6 carbon ring, which may be substituted as needed.

[0125] In some embodiments, for compounds or salts of formula (I), formula (ID), formula (IE), or formula (IF), each R 12 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 The carbon rings and 5- to 12-membered heterocycles are selected independently. In some cases, each R is selected. 12 is halogen, -OR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12The carbon rings and 5- to 12-membered heterocycles are selected independently. In some cases, each R is selected. 12 is halogen, -OR 20 , -N(R 20 )2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 The carbon rings and 5- to 12-membered heterocycles are selected independently. In some cases, each R is selected. 12 is halogen, -OR 20 , -N(R 20 )2, -CN, -NHCN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, and C 1~6 Selected independently from haloalkyl groups. In some cases, R 12 It is selected from -OH and -CN, R 1C Two R on the same atom 12 They combine to form an unsubstituted C3 carbon ring. In some cases, R 1C teeth, [ka] Selected from.

[0126] In some embodiments, for a compound or salt of formula (I), formula (ID), formula (IE), or formula (IF), R 1C It is selected from substituted 5-6 member complex rings as needed. In some cases, R 1C It is selected from the substituted 5-membered complex rings as needed. In some cases, R 1CIt is selected from a five-membered heterocycle having at least one oxygen atom, optionally substituted. In some cases, R 1C teeth, [ka] Selected from, which is replaced as needed. In some cases, each R 12 is halogen, -OR 20 , C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected from alkyl groups. In some cases, each R 12 It is selected from -OH. In some cases, R 1C teeth, [ka] That is the case.

[0127] In some embodiments, for compounds or salts of formula (I), formula (ID), formula (IE), or formula (IF), each R 12A is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is selected independently of alkinil.

[0128] In some embodiments, for a compound or salt of formula (I), formula (ID), formula (IE), or formula (IF), R 12 is -CN, and R 1C Two R on the same atom 12 Together, they form an unsubstituted C3 carbon ring.

[0129] In some embodiments, for a compound or salt of formula (I), formula (ID), formula (IE), or formula (IF), R 1C is hydrogen, and optionally substituted C 1~6 Selected from alkyl groups. In some cases, R 1C C is replaced as needed. 1~6 Selected from alkyl groups. In some cases, R 1C is hydrogen, and C 1~6 Selected from alkyl groups. In some cases, R 1C It is selected from hydrogen. In some cases, R 12 It is selected from -OH and -CN, R 1C Two R on the same atom 12 Together, they form an unsubstituted C3 carbon ring.

[0130] In some embodiments, for a compound or salt of formula (I), formula (ID), formula (IE), or formula (IF), R 1C teeth, [ka] Selected from.

[0131] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from.

[0132] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] That is the case.

[0133] In some embodiments, formula (I) is, [ka] or represented by a pharmaceutically acceptable salt thereof.

[0134] In some embodiments, formula (I) is, [ka] or represented by a pharmaceutically acceptable salt thereof.

[0135] In some embodiments, formula (I) is, [ka] or represented by a pharmaceutically acceptable salt thereof.

[0136] In some embodiments, for a compound or salt of formula (I), formula (IH), formula (II), or formula (IJ), R 1D C is replaced as needed. 1~6 Selected from alkyl groups. In some cases, R 1D C is replaced as needed. 1~6 Selected from alkyl groups, and R as needed.1D Two R on the same atom 13 They combine to form a C3-C6 carbon ring, which is substituted as needed. In some cases, R 13 It is selected from -OH and -CN, R 1D Two R on the same atom 13 They combine to form an unsubstituted C3 carbon ring. In some cases, R 1D teeth, [ka] Selected from.

[0137] In some embodiments, for compounds or salts of formula (I), formula (IH), formula (II), or formula (IJ), each R 13 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 The carbon rings and 5- to 12-membered heterocycles are selected independently. In some cases, each R is selected. 13 is halogen, -OR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 The carbon rings and 5- to 12-membered heterocycles are selected independently. In some cases, each R is selected. 13 is halogen, -OR 20 , -N(R 20 )2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 The carbon rings and 5- to 12-membered heterocycles are selected independently. In some cases, each R is selected. 13 is halogen, -OR 20 , -N(R 20 )2, -CN, -NHCN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, and C 1~6 It is independently selected from haloalkyl groups.

[0138] In some embodiments, for compounds or salts of formula (I), formula (IH), formula (II), or formula (IJ), each R 13A is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is selected independently of alkinil.

[0139] In some embodiments, for a compound or salt of formula (I), R 100 teeth, [ka] Selected from.

[0140] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1A and R 1B Together with the atoms they bond to, R 1 It forms.

[0141] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1B and R 1A Together with the atoms they bond to, R 1 It forms.

[0142] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 This is a 5- to 12-membered heterocyclic ring, and the 5- to 12-membered heterocyclic ring is substituted as needed. In some cases, R 1B and R 1A These, together with the atoms they bond to, form a 5- to 12-membered heterocycle, which is substituted as needed, and the 5- to 12-membered heterocycle is substituted as needed. In some cases, R1B and R 1A These, together with the atoms they bond to, form a bridging heterocycle. In some cases, R 1B and R 1A These, together with the atoms they bond to, form a spiroheterocycle. In some cases, R 1B and R 1A These, together with the atoms they bond to, form a fused heterocycle. In some cases, R 1B and R 1A These, together with the atoms they bond to, form a non-aromatic heterocycle. In some cases, R 1B and R 1A These, together with the atoms to which they bond, form a saturated heterocycle. Each heterocycle may be substituted as described elsewhere in this specification.

[0143] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The complex rings of are 5-12 member complex rings, 6-12 member complex rings, 7-12 member complex rings, or 8-12 member complex rings. In some cases, R 1 The complex rings of are 5-11 member complex rings, 5-10 member complex rings, 5-9 member complex rings, or 5-8 member complex rings. In some cases, R 1 The complex rings of are 6-11 member complex rings, 6-10 member complex rings, 6-9 member complex rings, or 6-8 member complex rings. In some cases, R 1 The complex rings of are 7-11 member complex rings, 7-10 member complex rings, 7-9 member complex rings, or 7-8 member complex rings. In some cases, R 1 The complex rings of are 5-6 member complex rings or 5-9 member complex rings. In some cases, R 1 The complex ring of is an 8- to 9-member complex ring. In some cases, R 1 The heterocycle of is saturated. The heterocycle is substituted as necessary, as described elsewhere in this specification.

[0144] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 It is a 5- to 12-membered monoring heteroring. In some cases, R 1 The complex rings of are 5-12 member monoring complex rings, 6-12 member monoring complex rings, 7-12 member monoring complex rings, or 8-12 member monoring complex rings. In some cases, R 1 The heterorings of are 5-11 member monoring heterorings, 5-10 member monoring heterorings, 5-9 member monoring heterorings, or 5-8 member monoring heterorings. In some cases, R 1 The complex rings of are 6- to 11-member monoring complex rings, 6- to 10-member monoring complex rings, 6- to 9-member monoring complex rings, or 6- to 8-member monoring complex rings. In some cases, R 1 The complex rings of are monoring 7- to 11-membered complex rings, 7- to 10-membered monoring complex rings, 7- to 9-membered monoring complex rings, or 7- to 8-membered monoring complex rings. In some cases, R 1 The complex rings of are 5-6 member monoring complex rings or 5-9 member monoring complex rings. In some cases, R 1 The complex ring of is an 8- to 9-membered monoring complex ring. In some cases, R 1 The heterocyclic ring of is saturated. Monocyclic heterocyclic rings are substituted as needed, as described elsewhere in this specification.

[0145] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 It is a bridging heterocycle. In some cases, R 1 The heterocyclic rings of are 5-12 membered bridging heterocyclic rings, 6-12 membered bridging heterocyclic rings, 7-12 membered bridging heterocyclic rings, or 8-12 membered bridging heterocyclic rings. In some cases, R 1 The heterocycles of are 5-11 membered bridging heterocycles, 5-10 membered bridging heterocycles, 5-9 membered bridging heterocycles, or 5-8 membered bridging heterocycles. In some cases, R 1 The heterocyclic rings of are 6-11 membered bridging heterocyclic rings, 6-10 membered bridging heterocyclic rings, 6-9 membered bridging heterocyclic rings, or 6-8 membered bridging heterocyclic rings. In some cases, R 1The heterocycles are bridging 7-11 member heterocycles, 7-10 member bridging heterocycles, 7-9 member bridging heterocycles, or 7-8 member bridging heterocycles. In some cases, R 1 The heterocycle of is a 5-6 membered bridged heterocycle or a 5-9 membered bridged heterocycle. In some cases, R 1 The complex ring of is an 8- to 9-membered bridge complex ring. In some cases, R 1 The heterocycle of is saturated. In some cases, the bridging heterocycle is [ka] Selected from. In some cases, the bridging heterocycle is [ka] Selected from the above. Each crosslinking heterocycle is substituted as necessary, as described elsewhere in this specification.

[0146] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 R is a spiroheterocyclic ring. 1 The spiroheterocycles are 7-12 membered spiroheterocycles, 7-12 membered spiroheterocycles, or 8-12 membered spiroheterocycles. In some cases, R 1 The spiroheterocycles are 7-11 member spiroheterocycles, 7-10 member spiroheterocycles, 7-9 member spiroheterocycles, or 7-8 member spiroheterocycles. In some cases, R 1 The spiroheterocycles are 7-11 member spiroheterocycles, 7-10 member spiroheterocycles, 7-9 member spiroheterocycles, or 7-8 member spiroheterocycles. In some cases, R 1 The spiroheterocycle is a 7- to 11-membered spiroheterocycle. In some cases, R 1 The spiroheterocyclic ring is a 7-membered spiroheterocyclic ring. In some cases, R 1 The spiroheteroring of is an 8-membered spiroheteroring. In some cases, R 1 The spiroheterocyclic ring of is a 9-membered spiroheterocyclic ring. In some cases, R 1 The spiroheterocyclic ring of is a 10-membered spiroheterocyclic ring. In some cases, R1 The spiroheterocycle contains at most one nitrogen atom. In some cases, R 1 The spiroheterocycle contains only one nitrogen atom. In some cases, R 1 The spiroheterocycle contains a maximum of two heteroatoms. In some cases, R 1 The spiroheterocycle contains at least two heteroatoms. In some cases, R 1 The spiroheterocycle contains at least three heteroatoms. In some cases, the heteroatoms are selected from nitrogen, oxygen, and sulfur. In some cases, R 1 The spiroheterocycle is bonded to the formula via a nitrogen atom. In some embodiments, R 1 The spiroheterogene is, [ka] Selected from. In some cases, R 1 The spiroheterogene is, [ka] Selected from the following. Each spiroheterocycle is substituted as necessary, as described elsewhere in this specification.

[0147] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 It is a condensed heteroalgebra. In some cases, R 1 The condensed heterocycles of are 6-12 member condensed heterocycles, 6-12 member condensed heterocycles, 7-12 member condensed heterocycles, or 8-12 member condensed heterocycles. In some cases, R 1 The condensed heterocycles of are 6-11 member condensed heterocycles, 6-10 member condensed heterocycles, 6-9 member condensed heterocycles, or 6-8 member condensed heterocycles. In some cases, R 1 The condensed heterocycles of are 7-11 member condensed heterocycles, 7-10 member condensed heterocycles, 7-9 member condensed heterocycles, or 7-8 member condensed heterocycles. In some cases, R 1 The condensed heteroalgebra of is an 8- to 11-membered condensed heteroalgebra. In some cases, R 1The condensed heteroalgebra of is a 6-membered condensed heteroalgebra. In some cases, R 1 The condensed heteroalgebra of is a 7-membered condensed heteroalgebra. In some cases, R 1 The condensed hetero ring of is a 10-membered condensed hetero ring. In some cases, the condensed hetero ring is [ka] Selected from the above. Each condensed heterocycle is substituted as necessary, as described elsewhere in this specification.

[0148] In some embodiments, for a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The 8-10 member fused heterocycle is selected as needed from the substituted 8-10 member fused heterocycles. In some cases, the 8-10 member fused heterocycle is a bicyclic heterocycle. In some cases, the 8-10 member fused heterocycle is a saturated heterocycle. In some cases, the 8-10 member fused heterocycle is an unsaturated heterocycle. In some cases, the 8-10 member fused heterocycle is a non-aromatic heterocycle. In some cases, R 1 It is selected from 9-membered condensed heterorings as needed. In some cases, R 1The 10-membered fused heterocycle is selected from substituted 10-membered heterocycles as needed. In some cases, the 10-membered fused heterocycle is a bicyclic heterocycle. In some cases, the 10-membered fused heterocycle is a saturated heterocycle. In some cases, the 9-membered heterocycle is a non-aromatic heterocycle. In some cases, the 10-membered heterocycle is a non-aromatic heterocycle. In some cases, the fused heterocycle has one saturated ring and one aromatic ring. In some cases, the fused heterocycle has one saturated ring and one unsaturated ring. In some cases, the fused heterocycle has two saturated rings. In some cases, the 10-membered heterocycle contains at least one nitrogen atom. In some cases, the 10-membered heterocycle contains at least two nitrogen atoms. In some cases, the 10-membered heterocycle contains at least three nitrogen atoms. In some cases, the 9-membered heterocycle contains at least one nitrogen atom. In some cases, the 9-membered heterocycle contains at least two nitrogen atoms. In some cases, a nine-membered heterocycle contains at least three nitrogen atoms. In some cases, R 1 teeth, [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, R 1 teeth, [ka] This is substituted as needed with one or more substituents. In some cases, R 1 teeth, [ka] This is substituted as needed with one or more substituents. In some cases, R 1 One or more substituents as needed may be halogen, -OH, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(=NR 20)N(R 20 )2, -C(O)N(R 20 )2, -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 An alkynyl and a 5- to 12-membered heterocycle are independently selected, and the 5- to 12-membered heterocycle is one or more R 1* They are substituted independently as needed. In some cases, R 1 One or more substituents as needed may be halogen, -OH, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C 2~6 Selected independently of alkynyl. In some cases, one or more substituents as needed are halogen, =O, -OH, -CN, -NHCN, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20), -C(O)R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, and C 1~6 Selected independently of alkyl groups. In some cases, one or more substituents as needed may be halogens, =O, C 1~6 alkyl-N(R 20 )2, -S(O)2(R 20 ), -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)R 20 ,-C(O)N(R 20 )2, and -C(O)NR 20 Ure 20 Selected independently from. In some cases, one or more substituents as needed are halogens, =O, -S(O)2(R 20 ), -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)R 20 ,-C(O)N(R 20 )2, and -C(O)NR 20 Ure 20 Selected independently from. In some cases, one or more substituents as needed are -C(O)R 20 ,-C(O)N(R 20 )2, and -C(O)NR 20 Ure 20 It is selected independently of the other. In some cases, one or more substituents as needed may be -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ) are selected independently. In some cases, one or more substituents as needed may be -S(O)N(R20 )2 is selected independently. In some cases, one or more substituents as needed may be S(O)2(R 20 ) are selected independently. In some cases, one or more substituents as needed are selected from S(O)R. 20 (=NR 20 ) are selected independently. In some cases, one or more substituents as needed are -C(O)R 20 Selected independently from. In some cases, one or more substituents as needed are -C(O)N(R 20 )2 is selected independently. In some cases, one or more substituents as needed may be -C(O)NR 20 Ure 20 It is selected independently of R. 1 teeth, [ka] Selected from, each of which is further substituted as needed. In some cases, one or more additional substituents as needed are halogen, -OH, =O, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C 2~6 Selected from alkynyls. In some cases, one or more additional substituents as needed may be halogens, -CN, C2 alkenyls, and C 1~6 Selected from alkyl groups. In some cases, one or more additional substituents as needed may be halogens and C 1~6 Selected from alkyl groups. In some cases, one or more additional substituents as needed are selected from halogens. In some cases, each R 20 is hydrogen; and C 1~6 Alkyl, C 3~12 A carbon ring and a 3- to 12-membered heterocycle are selected independently. In some cases, each R 20 is hydrogen; and C1~6 Alkyl and 3- to 12-membered heterocycles are independently selected. In some cases, each R 20 is hydrogen; and C 1~6 Alkyl and 3- to 12-membered saturated heterocycles are independently selected. In some cases, each R is selected. 20 The 5- to 6-membered saturated heteroalgebras are independently selected. In some cases, R 20 The heterocycle has at least one nitrogen atom. In some cases, R 20 The heterocycle has at least one sulfur atom. In some cases, R 20 The heterocycle has at least one oxygen atom. In some cases, R 20 The heterocycle contains only one heteroatom. In some cases, R 20 The heterocycle has at least two heteroatoms. In some cases, R 20 The heterocycle contains only two heteroatoms. In some cases, R 1 One or more substituents as needed may be halogens, -CN, C2 alkenyls, [ka] It is selected independently of R. 1 One or more substituents as needed may be halogens, [ka] It is selected independently of R. 1 One or more substituents as needed are [ka] It is selected independently of R. 1 One or more substituents as needed may be halogens, [ka] [ka] It is selected independently of R. 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 One or more substituents as needed are halogens and C 1~6 alkyl-N(R 20 )2 is selected independently. In some cases, R 1 One or more substituents as needed may be halogens, [ka] It is selected independently of R. 1 teeth, [ka] Selected from. In some cases, each R 20 is hydrogen, C 1~6 Alkyl, and C 3~6 It is selected independently from the carbon ring. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from, this is halogen, -OH, -S(O)2(R) 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(=NR 20 )N(R 20 )2, -C(O)OR 20 -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkynyl, optionally substituted with one or more substituents independently selected from a 5- to 12-membered heterocycle, where the 5- to 12-membered heterocycle is a halogen, -OR 20 , and C 1~6 It is optionally substituted with one or more substituents selected from alkyl groups. In some cases, R 1 teeth, [ka] Selected from, this is halogen and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 teeth, [ka] Selected from.

[0149] In some embodiments, for a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 teeth, [ka] Selected from, here, [ka] The R is selected from 5- to 12-membered hetero rings, and the 5- to 12-membered hetero ring is one or more R 1* It is independently replaced as needed; R B Hydrogen, halogen, C 1~6 Alkyl, C 1~6 Haloalkyl, C 2~6 Selected from alkynyl and -CN. In some cases, R B It is selected from hydrogen and halogens. In some cases, R B It is chlorine. In some cases, R B It is hydrogen. In some cases, [ka] It has at least 1, 2, 3, or 4 heteroatoms. In some cases, [ka] It has at least 1, 2, 3, or 4 nitrogen atoms. In some cases, [ka] It has at least one oxygen atom. In some cases, [ka] It is a monoring complex ring. In some cases, [ka] It is a biring complex algebra. In some cases, [ka] It is selected from the substituted 5-membered complex rings as needed. In some cases, [ka] It is selected from the 9-membered complex rings as needed. In some cases, [ka] teeth, [ka] Selected from, each of these is one or more R 1* It is replaced as needed. In some cases, [ka] teeth, [ka] Selected from, each of these is one or more R 1* It is replaced as needed. In some cases, each R 1* is halogen, -OR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20)C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, each R 1* is halogen, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, each R 1* is halogen, and C 1~6 It is selected independently of alkyl. In some cases, [ka] teeth, [ka] Selected from.

[0150] In some embodiments, for a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 However, -C(O)R 20 If it is replaced with R 20 The ring is selected from 5- to 12-membered heterogly rings, which are substituted as needed. In some cases, R 1is -C(O)R 20 It is replaced with R. In some cases, 20 It is selected from unsubstituted 5- to 12-membered heterogly rings. In some cases, R 20 The heterocycle is selected from 5-6 membered heterocycles, which are substituted as needed. In some cases, the heterocycle has at least one nitrogen atom. In some cases, the heterocycle has at least one sulfur atom. In some cases, the heterocycle has at least one oxygen atom. In some cases, the heterocycle has two heteroatoms. In some cases, R 20 The complex ring of is [ka] Selected from, each of which is replaced as necessary. In some cases, R 20 teeth, [ka] [ka] Selected from. In some cases, substituents as needed are C 1~10 Selected from alkyl, oxo, and =NH.

[0151] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), each R 20 hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, -N(C) 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 C as needed, substituted with one or more substituents independently selected from alkyl, oxo, and =NH. 1~6 Alkyl, C 3~12 A carbon ring and a 3- to 12-membered heterocycle are selected independently. In some cases, each R 20 hydrogen; and unsubstituted C 1~6Independently selected from alkyl and 3- to 12-membered heterocycles, these include halogens, -OH, -CN, -NO2, -NH2, and -N(C) 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 It is optionally substituted with one or more substituents independently selected from alkyl, oxo, and =NH groups.

[0152] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The molecule is selected from a 5- to 12-membered heterocycle, which is optionally substituted with one or more substituents. In some cases, the one or more substituents are halogens, -CN, -NO2, =O, -N(R) 20 )2, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6Selected independently of alkynyls. In some cases, one or more substituents as needed may be halogens, -OH, -N(R) 20 )2, -NO2, =O, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, and C 1~6 Selected independently from haloalkyls. In some cases, one or more substituents as needed may be halogen, -OH, -N(R) 20 )2, -NO2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, and C 1~6 Selected independently from haloalkyl groups. In some cases, R 20 is hydrogen and C 1~3 Selected from alkyl groups.

[0153] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 It is selected from saturated 5- to 12-membered heterocycles, which are optionally substituted with one or more substituents. In some cases, R 1 The 5- to 12-membered heterocycles are bridged. In some cases, R 1 The 5- to 12-membered hetero rings are not bridged. In some cases, the 5- to 12-membered hetero rings are [ka] [ka] Selected from these, each of which is optionally replaced with one or more substituents.

[0154] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 teeth, [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, one or more substituents as needed are halogens, -OH, -N(R) 20 )2, -B(OH)2, -C(O)N(R 20 )2, -NHCN, -NO2, C 1~6 Alkoxy, =O, -CN, C 1~6 Alkyl, C 2~6 Alkenil, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, and C 1~6 Selected independently from haloalkyl groups. In some cases, R 1 teeth, [ka] [ka] [ka] Selected from.

[0155] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The 5- to 12-membered unsaturated heterocycles are selected as needed, and each heterocycle has at most one nitrogen atom. In some cases, the 5- to 12-membered unsaturated heterocycle has at least one nitrogen atom. In some cases, the 5- to 12-membered unsaturated heterocycle has at most one nitrogen atom.

[0156] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1The heterocycle contains, as may be, a single nitrogen atom, and one or more heteroatoms selected from oxygen and sulfur. In some cases, the heterocycle is a fused heterocycle or a bridging heterocycle. In some cases, the heterocycle is a monocyclic heterocycle or a bridging heterocycle. In some cases, the heterocycle is a monocyclic heterocycle. In some cases, the heterocycle is a bridging heterocycle. In some cases, the heterocycle is, [ka] The complex rings are selected from the following. The complex rings are substituted as necessary, as described elsewhere in this specification.

[0157] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The heterocycle has at most one nitrogen atom. In some cases, R 1 The heterocycle has only one nitrogen atom, and optionally one or more other heteroatoms selected from oxygen and sulfur. In some cases, R 1 The heterocycle has only one nitrogen atom and no other heteroatoms.

[0158] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The heterocycle is selected from 5- to 12-membered saturated heterocycles, which are substituted as needed, and each heterocycle has at most one nitrogen atom. In some cases, the 5- to 12-membered unsaturated heterocycle has at least one nitrogen atom. In some cases, the 5- to 12-membered unsaturated heterocycle has only one nitrogen atom, as well as 0-2 other heteroatoms selected from nitrogen, oxygen, and sulfur. In some cases, the 5- to 12-membered unsaturated heterocycle has only one nitrogen atom and no further heteroatoms. In some cases, the 5- to 12-membered unsaturated heterocycle has three nitrogen atoms and no further heteroatoms.

[0159] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The heterocycle is selected from 5- to 12-membered unsaturated heterocycles, which are substituted as needed, and each heterocycle has at most one nitrogen atom. In some cases, the 5- to 12-membered unsaturated heterocycle has at least one nitrogen atom. In some cases, the 5- to 12-membered unsaturated heterocycle has only one nitrogen atom and no further heteroatoms.

[0160] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The complex ring is selected from 6- to 9-membered rings. In some cases, R 1 It is selected from 6- to 7-membered complex rings. In some cases, R 1 It is selected from 7-membered complex rings. In some cases, R 1 The 6- or 7-membered heterocycle is selected from a 6-membered heterocycle. In some cases, the 6- or 7-membered heterocycle contains only one nitrogen atom and, optionally, one or more additional heteroatoms selected from oxygen and sulfur. In some cases, optionally, one or more additional heteroatoms are selected from sulfur. In some cases, optionally, one or more additional heteroatoms are selected from oxygen. In some cases, the 6- or 7-membered heterocycle contains only one nitrogen atom and no additional heteroatoms. In some cases, the 6- or 7-membered heterocycle is a non-aromatic 6- or 7-membered heterocycle. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 teeth, [ka] Selected from, each of these is replaced. In some cases, R 1 The substituents are one or more halogens, -OR 20 , -SR 20, -N(R 20 )2, -NHCN, -NO2, =O, -CN, C 1~6 Haloalkyl, -C(O)N(R) 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each is selected from the alkinyls. In some cases, R 1 The substituents are one or more halogens, -OR 20 , -N(R 20 )2, -NHCN, =O, -CN, -C(O)N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Alkyl, and C 2~6 Each is selected from the alkinyls. In some cases, R 1 The substituents are one or more halogens, -OH, -NHCN, =O, -CN, C 2~6 Alkinyl and C 1~6 Each is selected from alkyl groups. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 One or more substituents as needed are fluorine, -OH, -C(O)NH2, -NH-C(O)-(C 1~6 Alkoxy), -NH-C(O)-(C 1~6 Hydroxyalkyl), -NH2, -NH(CN), =O, -CN, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Alkyl, and C 2~6 Each is independently selected from the alkinyls. In some cases, R 1 One or more substituents as needed may be halogen, -OH, -CN, C 1~6 Cyanoalkyl, C 1~6 Alkyl, and C 2~6 Each is independently selected from the alkinyls. In some cases, R 1 One or more substituents as needed are independently selected from halogens, -OH, and -CN, respectively. In some cases, R 1 One or more substituents as needed may be fluorine, -OH, -CN, C 1~6 Cyanoalkyl, C 1~6 Alkyl, oxo, and C 2~6 Each is independently selected from the alkinyls. In some cases, R 1 One or more substituents as needed may be fluorine, -OH, -CN, C 1~6 Cyanoalkyl, C 1~6 Alkyl, and C 2~6 Each is independently selected from the alkinyls. In some cases, R 1 teeth, [ka] [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from.

[0161] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 teeth, [ka] [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, one or more substituents as needed are halogens, -OH, -N(R) 20 )2, -B(OH)2, -C(O)N(R 20 )2, -NHCN, -NO2, C 1~6 Alkoxy, =O, -CN, C 1~6 Alkyl, C 2~6 Alkenil, C 1~6 Aminoalkyl, C 1~6 Cyanoalkyl, C 1~6 Hydroxyalkyl, and C 1~6 Selected independently from haloalkyl groups. In some cases, R 1 teeth, [ka] [ka] [ka] [ka] [ka] Selected from.

[0162] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 It is selected from unsaturated 6- to 8-membered heterocycles, which are substituted as needed. In some cases, R 1 It is selected from the unsaturated six-membered hetero rings as needed. In some cases, R 1 The heterocycle is selected from unsaturated seven-membered heterocycles, which are substituted as needed. In some cases, the heterocycle has one or two double bonds. In some cases, the heterocycle has only one double bond. In some cases, the heterocycle has only two double bonds. In some cases, R 1 teeth, [ka] Selected from, each is halogen, -OH, -NH2, -NO2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Haloalkyl and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 teeth, [ka] Selected from, each is halogen, -OH, -NH2, -NO2, C 1~6 Aminoalkyl, C 1~6Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Haloalkyl and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 teeth, [ka] Selected from, each is halogen, -OH, -NH2, -NO2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Haloalkyl and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] In some cases, R 1 teeth, [ka] They are selected from, and each is substituted with one or more substituents selected independently of the halogen.

[0163] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The unsaturated 6- to 7-membered heterocycle is selected, and the unsaturated 6- to 7-membered heterocycle is substituted with one or more substituents selected from halogens. In some cases, the unsaturated 6- to 7-membered heterocycle is substituted with at least one halogen. In some cases, the unsaturated 6- to 7-membered heterocycle is substituted with only one halogen. In some cases, the unsaturated 7-membered heterocycle is substituted with one fluorine. In some cases, R 1 It is selected from an unsaturated six-membered heterocycle substituted with at least one halogen. In some cases, R 1 It is selected from an unsaturated 7-membered heterocycle substituted with at least one halogen. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] and [ka] Selected from. In some cases, R 1 teeth, [ka] In some cases, R 1 teeth, [ka] In some cases, R 1 teeth, [ka] That is the case.

[0164] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 It is selected from unsaturated 6- to 8-membered heterocycles, which are substituted as needed. In some cases, R 1 It is selected from the unsaturated 7-membered hetero rings as needed. In some cases, R 1 teeth, [ka] Selected from, each is halogen, -OH, -NH2, -NO2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Haloalkyl and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 teeth, [ka] Selected from.

[0165] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The six-membered heterocycle is selected as needed from substituted six-membered heterocycles. In some cases, the six-membered heterocycle contains only one nitrogen atom. In some cases, R 1 The six-membered heterocycles are bonded to each other via only one nitrogen atom. In some cases, R 1 teeth, [ka] Selected from, any of these is replaced as needed. In some cases, R 1 One or more substituents as needed may be halogens, -OR 20 , -N(R 20 )2, =O, -CN, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Alkyl, and C 2~6 Each is independently selected from the alkinyls. In some cases, R 1 One or more substituents as needed may be fluorine, -OH, -NH2, -NH(CN), =O, -CN, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Alkyl, and C 2~6 Each is independently selected from the alkinyls. In some cases, R 1 One or more substituents as needed may be fluorine, -OH, -NH2, -NH(CN), =O, -CN, C 1~6 Hydroxyalkyl, C 1~6 Alkyl, and C 2~6 Each is independently selected from the alkynyl group. In some cases, the 6-membered heterocycle is a partially unsaturated or saturated 6-membered heterocycle. In some cases, the 6-membered heterocycle is partially unsaturated. In some cases, the 6-membered heterocycle is saturated. In some cases, the 6-membered heterocycle is a monocyclic 6-membered heterocycle. In some cases, the 6-membered heterocycle is not a bridging heterocycle. In some cases, R 1 teeth, [ka] Selected from.

[0166] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 These are selected from substituted six-membered unsaturated and six-membered saturated heterocycles as needed. In some cases, R 1 teeth, [ka] Selected from, each is halogen, -OH, -NH2, -NO2, C 1~6 Aminoalkyl, C 1~6 Cyanoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Haloalkyl and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 teeth, [ka] Selected from, each is halogen and C 1~6 It is optionally substituted with one or more substituents independently selected from the haloalkyl group. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from, this is halogen, C 1~6 Cyanoalkyl, and C 1~6 It is optionally substituted with one or more substituents independently selected from the haloalkyl group. In some cases, R 1 teeth, [ka] That is the case.

[0167] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 teeth, [ka] Selected from, each is halogen, -OH, -NH2, -NO2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Haloalkyl and C 1~6 It is optionally substituted with two substituents independently selected from the alkyl group. In some cases, R 1 teeth, [ka] Selected from, each is halogen and C 1~6 It is optionally substituted with two substituents independently selected from the haloalkyl group. In some cases, R 1 teeth, [ka] That is the case.

[0168] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The 6-10 membered heterocycle is selected as needed from substituted 6-10 membered heterocycles. In some cases, the 6-10 membered heterocycle contains 0-2 additional heteroatoms selected from nitrogen, oxygen, and sulfur. In some cases, the 6-10 membered heterocycle contains at least one nitrogen atom. In some cases, R 1 teeth, [ka] Selected from these, each of these is a halogen, -O, -OH, -CN, -NHCN, -C(O)N(R) 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, and C 1~6 It is optionally substituted with one or more substituents selected independently of the alkyl group. In some cases, each R 20hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, -N(C) 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Alkyl, oxo, C 3~12 C as needed, substituted with one or more substituents independently selected from carbocyclic and 3- to 12-membered heterocycles. 1~6 Alkyl, C 3~12 A carbon ring and a 3- to 12-membered heterocycle are independently selected. In some cases, R 1 teeth, [ka] Selected from.

[0169] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 It is selected from 6- to 7-membered complex rings. In some cases, R 1 It is selected from 7-membered complex rings. In some cases, R 1 The 6- or 7-membered heterocycle is selected from a 6-membered heterocycle. In some cases, the 6- or 7-membered heterocycle contains only one nitrogen atom and, optionally, one or more additional heteroatoms selected from oxygen and sulfur. In some cases, optionally, one or more additional heteroatoms are selected from sulfur. In some cases, optionally, one or more additional heteroatoms are selected from oxygen. In some cases, the 6- or 7-membered heterocycle contains only one nitrogen atom and no additional heteroatoms. In some cases, the 6- or 7-membered heterocycle is a non-aromatic 6- or 7-membered heterocycle. In some cases, R 1 The 6-7 membered heterocycles are bonded to each other via only one nitrogen atom. In some cases, R 1 teeth, [ka] Selected from, each of these is replaced. In some cases, R 1 teeth, [ka] Selected from, each of these is replaced. In some cases, R 1 The substituents are one or more halogens, -OR 20 , -SR 20 , -N(R 20 )2, -NHCN, -NO2, =O, -CN, C 1~6 Fluoroalkyl, and C 2~6 Each is selected from alkinyl;-C(O)N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Alkyl, and C 2~6 It is further optionally substituted with one or more substituents independently selected from the alkenyl. In some cases, R 1 The substituents are one or more halogens, -OR 20 , -N(R 20 )2, -NHCN, =O, -CN, and C 2~6 Each is selected from alkinyl;-C(O)N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, and C 1~6 It is further optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 The substituents are one or more halogens, -OH, -NHCN, =O, -CN, and C 2~6 Each is selected from Alkinil; C 1~6 It is further optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 One or more substituents as needed are fluorine, -OH, -C(O)NH2, -NH-C(O)-(C 1~6 Alkoxy), -NH-C(O)-(C 1~6 Hydroxyalkyl), -NH2, -NH(CN), =O, -CN, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Alkyl, and C 2~6 Each is independently selected from the alkinyls. In some cases, R 1 One or more substituents as needed may be halogen, -OH, -CN, C 1~6 Cyanoalkyl, C 1~6 Alkyl, and C 2~6 Each is independently selected from the alkinyls. In some cases, R 1 One or more substituents as needed are independently selected from halogens, -OH, and -CN, respectively. In some cases, R 1 One or more substituents as needed may be fluorine, -OH, -CN, C 1~6 Cyanoalkyl, C 1~6 Alkyl, oxo, and C 2~6 Each is independently selected from the alkinyls. In some cases, R 1 One or more substituents as needed may be fluorine, -OH, -CN, C 1~6 Cyanoalkyl, C1~6 Alkyl, and C 2~6 Each is independently selected from the alkinyls. In some cases, R 1 teeth, [ka] [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from.

[0170] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The 5- to 12-membered heterocycles are unsaturated bridging heterocycles. In some cases, R 1 It is selected from substituted 7- to 8-membered unsaturated bridged heterocycles as needed. In some cases, R 1 teeth, [ka] Selected from.

[0171] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 These are selected from 5-10 membered heterocycles, 7, 8, 10, and 11 membered spiroheterocycles, and 6, 9, 10, 11, and 12 membered condensed heterocycles, each being a halogen, -N(R) 20 )2, C 1~6 Alkyl, -OR 20 , -N(R 20 )C(O)N(R 20 )2, -B(OR 20 )2, C 1~6 Cyanoalkyl, -N(R 20 )C(O)N(R 20 )2, =O,C 1~6 Hydroxyalkyl, halogen, -N(R 20 )C(O)R 20 , -N(R 20 )S(O)2(R 20 ), and C 1~6 It is optionally substituted with one or more substituents independently selected from the aminoalkyl group. In some cases, R 1 teeth, [ka] Selected from, each is halogen, -N(R 20 )2, C 1~6 Alkyl, -OR 20 , -N(R 20 )C(O)N(R 20 )2, -B(OR 20 )2, C 1~6 Cyanoalkyl, -N(R 20 )C(O)N(R 20 )2, =O,C 1~6 Hydroxyalkyl, halogen, -N(R 20 )C(O)R 20 , -N(R 20 )S(O)2(R 20 ), and C 1~6 It is optionally substituted with one or more substituents independently selected from the aminoalkyl group. In some cases, R 1 teeth, [ka] [ka] Selected from.

[0172] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The 10-membered heterocycle is selected from substituted 10-membered heterocycles as needed. In some cases, the 10-membered heterocycle is a bicyclic heterocycle. In some cases, the 10-membered heterocycle is a spiroheterocycle. In some cases, the 10-membered heterocycle is a fused heterocycle. In some cases, the 10-membered heterocycle is a saturated heterocycle. In some cases, the 10-membered heterocycle is a non-aromatic heterocycle. In some cases, the 10-membered heterocycle contains at least one nitrogen atom. In some cases, the 10-membered heterocycle contains at least two nitrogen atoms. In some cases, the 10-membered heterocycle contains at least three nitrogen atoms. In some cases, the 10-membered heterocycle contains at least one sulfur atom. In some cases, R 1 teeth, [ka] Selected from these, each of these is a halogen, -O, -OH, -CN, -NHCN, -C(O)N(R) 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from, this is halogen, -OR 20 , -SR 20 , -N(R 20 )2, -NO2, =O, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl molecule.

[0173] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 It is selected from unsaturated 9- to 11-membered heterocycles as needed. In some cases, R 1 It is selected from unsaturated 10-membered hetero rings, which are substituted as needed. In some cases, R 1 It is selected from unsaturated 10-membered condensed heterocycles as needed. In some cases, R 1 teeth, [ka] This is substituted as needed. In some cases, one or more substituents as needed are halogens, -OH, -C(O)N(R) 20 )2, -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C2~6 Selected from alkinyl. In some cases, R 1 is -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C 2~6 Substituted as needed with one or more substituents selected from alkynyl [ka] In some cases, each R 20 hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Alkyl, C 2~10 Alkenil, C 2~10 Alkinyl, C 3~12 C as needed, substituted with one or more substituents independently selected from carbocyclic and 3- to 12-membered heterocycles. 1~6 Alkyl, and C 3~12 It is selected independently of the carbon ring.

[0174] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The is selected from 7- to 11-membered spiroheterocyclic rings. In some cases, R 1 The is selected from a 10-membered spiroheterocycle. In some cases, the spiroheterocycle has at least 3 nitrogen atoms. In some cases, the spiroheterocycle has at least 1 sulfur atom. In some cases, R 1 teeth, [ka] Selected from, each of which is substituted as needed. In some cases, one or more substituents as needed are halogens, -OH, -N(R) 20 )2, -NO2, =O, -CN, -NHCN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is selected independently of alkinyl. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] In some cases, R 1 teeth, [ka] That is the case.

[0175] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The 8-10 member fused heterocycle is selected as needed from the substituted 8-10 member fused heterocycles. In some cases, the 8-10 member fused heterocycle is a bicyclic heterocycle. In some cases, the 8-10 member fused heterocycle is a saturated heterocycle. In some cases, the 8-10 member fused heterocycle is an unsaturated heterocycle. In some cases, the 8-10 member fused heterocycle is a non-aromatic heterocycle. In some cases, R 1The 10-membered fused heterocycle is selected from substituted 10-membered heterocycles as needed. In some cases, the 10-membered fused heterocycle is a bicyclic heterocycle. In some cases, the 10-membered fused heterocycle is a saturated heterocycle. In some cases, the 10-membered heterocycle is a non-aromatic heterocycle. In some cases, the fused heterocycle has one saturated ring and one aromatic ring. In some cases, the fused heterocycle has one saturated ring and one unsaturated ring. In some cases, the fused heterocycle has two saturated rings. In some cases, the 10-membered heterocycle contains at least one nitrogen atom. In some cases, the 10-membered heterocycle contains at least two nitrogen atoms. In some cases, the 10-membered heterocycle contains at least three nitrogen atoms. In some cases, R 1 teeth, [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, R 1 teeth, [ka] This is substituted as needed with one or more substituents. In some cases, R 1 One or more substituents as needed may be halogen, -OH, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C2~6 Selected independently of alkynyl. In some cases, one or more substituents as needed are halogen, =O, -OH, -CN, -NHCN, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, and C 1~6 Selected independently of alkyl groups. In some cases, one or more substituents as needed may be halogens, =O, C 1~6 alkyl-N(R 20 )2, -S(O)2(R 20 ), -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)R 20 ,-C(O)N(R 20 )2, and -C(O)NR 20 Ure 20 Selected independently from. In some cases, one or more substituents as needed are halogens, =O, -S(O)2(R 20 ), -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)R 20 ,-C(O)N(R 20 )2, and -C(O)NR 20 Ure 20 It is selected independently of R. 1 teeth, [ka] Selected from, each of which is substituted as needed. In some cases, one or more substituents as needed are -C(O)R 20 ,-C(O)N(R 20 )2, and -C(O)NR 20 Ure 20 It is selected independently of the other. In some cases, one or more substituents as needed may be -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ) are selected independently. In some cases, one or more substituents as needed may be -S(O)N(R 20 )2 is selected independently. In some cases, one or more substituents as needed may be S(O)2(R 20 ) are selected independently. In some cases, one or more substituents as needed are selected from S(O)R. 20 (=NR 20 ) are selected independently. In some cases, one or more substituents as needed are -C(O)R 20 Selected independently from. In some cases, one or more substituents as needed are -C(O)N(R 20 )2 is selected independently. In some cases, one or more substituents as needed may be -C(O)NR 20 Ure 20 It is selected independently of each R. 20 is hydrogen; and C 1~6 Alkyl, C 3~12 A carbon ring and a 3- to 12-membered heterocycle are selected independently. In some cases, each R 20 is hydrogen; and C 1~6 Alkyl and 3- to 12-membered heterocycles are independently selected. In some cases, each R 20 is hydrogen; and C 1~6 Alkyl and 3- to 12-membered saturated heterocycles are independently selected. In some cases, R 1 One or more substituents as needed may be halogens, [Chemical formula] is independently selected from. In some cases, R 1 is [Chemical formula] [Chemical formula] is selected from. In some cases, R 1 is [Chemical formula] is selected from. In some cases, R 1 One or more substituents as required for are halogen, and C 1~6 alkyl-N(R 20 )2 are independently selected from. In some cases, R 1 One or more substituents as required for are halogen, [Chemical formula] [Chemical formula] is selected from. In some cases, R 1 is [Chemical formula] is selected from. In some cases, each R 20 is hydrogen, C 1~6 alkyl, and C 3~6 carbocyclic ring are independently selected from. In some cases, R 1 is [Chemical formula] is selected from.

[0176] In some embodiments, for the compound or salt of formula (I), formula (I-A), formula (I-B), formula (I-C) or formula (I-G), R 1The 8-10 member fused heterocycle is selected as needed from the substituted 8-10 member fused heterocycles. In some cases, the 8-10 member fused heterocycle is a bicyclic heterocycle. In some cases, the 8-10 member fused heterocycle is a saturated heterocycle. In some cases, the 8-10 member fused heterocycle is an unsaturated heterocycle. In some cases, the 8-10 member fused heterocycle is a non-aromatic heterocycle. In some cases, R 1 The 10-membered fused heterocycle is selected from substituted 10-membered heterocycles as needed. In some cases, the 10-membered fused heterocycle is a bicyclic heterocycle. In some cases, the 10-membered fused heterocycle is a saturated heterocycle. In some cases, the 10-membered heterocycle is a non-aromatic heterocycle. In some cases, the fused heterocycle has one saturated ring and one aromatic ring. In some cases, the fused heterocycle has one saturated ring and one unsaturated ring. In some cases, the fused heterocycle has two saturated rings. In some cases, the 10-membered heterocycle contains at least one nitrogen atom. In some cases, the 10-membered heterocycle contains at least two nitrogen atoms. In some cases, the 10-membered heterocycle contains at least three nitrogen atoms. In some cases, R 1 teeth, [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, R 1 teeth, [ka] and [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, R 1 teeth, [ka] This is substituted as needed with one or more substituents. In some cases, R 1One or more substituents as needed may be halogen, -OH, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C 2~6 Selected independently of alkynyl. In some cases, one or more substituents as needed are halogen, =O, -OH, -CN, -NHCN, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, and C 1~6 Selected independently of alkyl groups. In some cases, one or more substituents as needed may be halogens, =O, C 1~6 alkyl-N(R 20 )2, -S(O)2(R 20 ), -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)R 20,-C(O)N(R 20 )2, and -C(O)NR 20 Ure 20 Selected independently from. In some cases, one or more substituents as needed are halogens, =O, -S(O)2(R 20 ), -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)R 20 ,-C(O)N(R 20 )2, and -C(O)NR 20 Ure 20 Selected independently from. In some cases, one or more substituents as needed are -C(O)R 20 ,-C(O)N(R 20 )2, and -C(O)NR 20 Ure 20 It is selected independently of the other. In some cases, one or more substituents as needed may be -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ) are selected independently. In some cases, one or more substituents as needed may be -S(O)N(R 20 )2 is selected independently. In some cases, one or more substituents as needed may be S(O)2(R 20 ) are selected independently. In some cases, one or more substituents as needed are selected from S(O)R. 20 (=NR 20 ) are selected independently. In some cases, one or more substituents as needed are -C(O)R 20 Selected independently from. In some cases, one or more substituents as needed are -C(O)N(R 20 )2 is selected independently. In some cases, one or more substituents as needed may be -C(O)NR 20 Ure 20 It is selected independently of R. 1 teeth, [ka] [ka] Selected from, each of which is further substituted as needed. In some cases, one or more additional substituents as needed are halogen, -OH, =O, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C 2~6 Selected from alkynyls. In some cases, one or more additional substituents as needed may be halogens and C 1~6 Selected from alkyl groups. In some cases, one or more additional substituents as needed are selected from halogens. In some cases, each R 20 is hydrogen; and C 1~6 Alkyl, C 3~12 A carbon ring and a 3- to 12-membered heterocycle are selected independently. In some cases, each R 20 is hydrogen; and C 1~6 Alkyl and 3- to 12-membered heterocycles are independently selected. In some cases, each R 20 is hydrogen; and C 1~6 Alkyl and 3- to 12-membered saturated heterocycles are independently selected. In some cases, each R is selected. 20 The 5- to 6-membered saturated heteroalgebras are independently selected. In some cases, R 20 The heterocycle has at least one nitrogen atom. In some cases, R 20 The heterocycle has at least one sulfur atom. In some cases, R 20 The heterocycle has at least one oxygen atom. In some cases, R 20 The heterocycle contains only one heteroatom. In some cases, R 20 The heterocycle has at least two heteroatoms. In some cases, R 20The complex ring contains only two heteroatoms. In some cases, R 1 One or more optional substituents of are halogen,

Chem.

Chem.

Chem.

Chem.

Chem.

Chem.

Chem.

Chem.

[0177] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 However, -C(O)R 20 If it is replaced with R 20 The complex ring is selected from 5- to 12-membered complex rings.

[0178] In some embodiments, for a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 teeth, [ka] And R 1 One or more substituents as needed may be halogen, -OH, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(=NR 20 )N(R 20 )2, -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6Haloalkyl, C 1~6 Alkyl, C 2~6 Alkynnyls and optionally substituted 5- to 12-membered heterorings are independently selected. In some cases, R 1 One or more substituents as needed may be halogen, -OH, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(=NR 20 )N(R 20 )2, -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkynnyls and optionally substituted 5- to 12-membered heterorings are independently selected. In some cases, R 1 One or more substituents as needed may be halogen, -CN, C 2~6 Alkinyl, -C(=NR) 20 )N(R 20 )2, and independently selected from 5- to 12-membered heterorings as needed. In some cases, R 1 One or more substituents as needed may be halogens, -C(=NR 20 )N(R 20 )2, and independently selected from 5- to 12-membered heterorings as needed. In some cases, R 1 One or more substituents as needed are -C(=NR 20 )N(R 20)2, and independently selected from 5- to 12-membered heterorings as needed. In some cases, R 1 One or more substituents as needed are independently selected from the optionally substituted 5- to 12-membered heterocycles. In some cases, R 1 One or more optional substituents are independently selected from 5-membered heterocycles and 9-membered heterocycles, each of which has one or more R 1* It is replaced independently as needed. In some cases, R 1 It is substituted with at least one halogen atom, -CN,C 2~6 Alkinyl, -C(=NR) 20 )N(R 20 )2, and optionally substituted with one or more substituents independently selected from a 5- to 12-membered heterocycle, the 5- to 12-membered heterocycle being one or more R 1* They are independently substituted as needed. In some cases, the heterocycle has at least one nitrogen atom. In some cases, the heterocycle has at least one oxygen atom. In some cases, the heterocycle has at least one nitrogen atom and at least one oxygen atom. In some cases, the heterocycle has at least two heteroatoms. In some cases, the heterocycle has at least three heteroatoms. In some cases, the heterocycle has at least four heteroatoms. In some cases, R 1 The heterocycle of one or more optional substituents is [ka] Selected from, each of these is one or more R 1* It is replaced as needed. In some cases, R 1 The heterocycle of one or more optional substituents is [ka] Selected from, this is one or more R 1* It is replaced as needed. In some cases, each R 1* is halogen, -OR 20-S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, each R 1* is halogen, -OR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20)2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, each R 1* is halogen, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, each R 1* is halogen, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, each R 1* is halogen, and C 1~6 Selected independently of alkyl. In some cases, each R 1* It is selected independently of halogens. In some cases, each R 1* C 1~6 Selected independently of alkyl. In some cases, each R 1* is -OR 20 It is selected independently of each R. 1* It was selected independently of -OH. In some cases, each R 1* It is selected independently of -OMe. In some cases, R1 The heterocycle of one or more optional substituents is [ka] Selected from.

[0179] In some embodiments, for a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 One or more substituents as needed are -C(=NR 20 )N(R 20 )2, and independently selected from 5- to 12-membered heterorings as needed. In some cases, R 1 One or more substituents as needed are independently selected from the optionally substituted 5- to 12-membered heterocycles. In some cases, the heterocycle is [ka] Selected from, each of these is one or more R 1* It is replaced as needed. In some cases, R 1 One or more substituents as needed are [ka] Selected from.

[0180] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), each R 1* is halogen, -OR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20)C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, each R 1* is halogen, -OR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, each R 1* is halogen, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, each R 1* is halogen, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, each R 1* is halogen, and C 1~6 Selected independently of alkyl. In some cases, each R 1* It is selected independently of halogens. In some cases, each R 1* C 1~6 It is selected independently of alkyl.

[0181] In some embodiments, for a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The ion is selected from 5-15 membered heterocycles (preferably 8-10 membered heterocycles or preferably 10 membered heterocycles), each of which is a halogen, oxo, or -C(O)N(R) 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 , -SO2R 20 , -NHCN, C 1~6 Cyanoalkyl, C 1~6 Alkyl, C 1~6alkyl-N(R 20 )2, C 2~6 The alkynyl and one or more substituents optionally selected independently from a 5- to 12-membered heterocycle (preferably a 5- to 9-membered heterocycle), wherein the 5- to 12-membered heterocycle is one or more R 1* They are independently substituted as needed; each R 1* is halogen, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl groups. In some cases, the 8- to 10-membered heterocycles are bicyclic. In some cases, the 10-membered heterocycles are substituted. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 teeth, [ka] Selected from, which is replaced as needed. In some cases, R 1 teeth, [ka] [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] That is the case.

[0182] In some embodiments, for a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1The is selected from 5-15 membered heterocycles (preferably 8-10 membered heterocycles, or preferably 10 membered heterocycles, or preferably 8 membered heterocycles), each of which is a halogen, -C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 , -NHCN, C 1~6 Cyanoalkyl, C 1~6 Alkyl, C 2~6 The alkynyl and one or more substituents optionally selected independently from a 5- to 12-membered heterocycle (preferably a 5- to 6-membered heterocycle), wherein the 5- to 12-membered heterocycle is one or more R 1* They are independently substituted as needed; each R 1* is halogen, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl groups. In some cases, the 8- to 10-membered heterocycles are bicyclic. In some cases, the 10-membered heterocycles are substituted. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 teeth, [ka] Selected from, which is replaced as needed. In some cases, R 1 teeth, [ka] [ka] Selected from. In some cases, R 1 teeth, [ka] Selected from.

[0183] In some embodiments, for a compound or salt of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 These are selected from substituted 7-10 member spiroheterocycles and substituted 7-10 member condensed heterocycles as needed. In some cases, R 1 The heterocycle has at least one nitrogen atom. In some cases, R 1 At least one nitrogen atom of the heterocycle is bonded to formula (I). In some cases, R 1 These are selected from optionally substituted 10-membered spiroheterocycles and optionally substituted 10-membered fused heterocycles. In some cases, R 1 One or more substituents as needed may be halogen, -OH, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(=NR 20 )N(R 20 )2, -C(O)OR 20 -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkynnyls are independently selected from 5- to 12-membered heterocycles, and these 5- to 12-membered heterocycles include halogens and C. 1~6 It is optionally substituted with one or more substituents selected from alkyl groups. In some cases, R 1 teeth, [ka] Selected from, this is halogen, -OH, -S(O)2(R) 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(=NR 20 )N(R 20 )2, -C(O)OR 20 -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkynyl, substituted with one or more substituents independently selected from a 5-12 membered heterocycle, where the 5-12 membered heterocycle is a halogen and C 1~6 It is optionally substituted with one or more substituents selected from alkyl groups. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] [ka] Selected from.

[0184] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R1 The 6- to 11-membered heterocycle is selected as needed, and each 6- to 11-membered heterocycle has at least one nitrogen atom. In some cases, R 1 One or more substituents as needed may be halogens, -OR 20 ,-C(O)N(R 20 )2, -C(O)R 20 -S(O)2R 20 , =O, -C 1~6 Alkyl (=NR) 20 Ure 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 Selected from alkyl and 5-12 membered heterocycles, the 5-12 membered heterocycle is one or more R 1* They are independently substituted as needed; each R 1* is halogen, and C 1~6 Selected independently of alkyl. In some embodiments, R 1 teeth, [ka] [ka] Selected from. In some cases, R 1 is hydrogen, [ka] [ka] Selected from. In some cases, R 1 is hydrogen, [ka] [ka] Selected from.

[0185] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R1 R is selected from hydrogen and optionally substituted 5- to 15-membered heterocycles. In some cases, R 1 teeth, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 One or more substituents as needed are -OH, =NO(R 20 ), -NHCN, and C 1~6 Selected from alkyl groups. In some cases, R 1 is hydrogen, [ka] [ka] Selected from.

[0186] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 teeth, [ka] That is the case.

[0187] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 R is selected from hydrogen and optionally substituted 7- to 10-membered heterocycles. In some cases, R 1 is hydrogen, [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 One or more substituents as needed may be halogen, -NH2, -S(O)2(R 20 ), -C(O)R 20 ,-C(O)N(R 20)2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 Alkyl and 5-12 membered heterocycles are independently selected, and the 5-12 membered heterocycle is one or more R 1* They are independently substituted as needed; each R 1* is halogen, and C 1~6 Selected independently of alkyl. In some cases, R 1 is hydrogen, [ka] [ka] Selected from.

[0188] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The heterocycle is selected from 8- to 10-membered heterocycles as needed. In some cases, the heterocycle is bicyclic. In some cases, the heterocycle has at least one nitrogen atom. In some cases, the heterocycle has at least two nitrogen atoms. In some cases, [ka] Each of these is replaced as needed. In some cases, R 1 One or more substituents as needed may be halogens, [ka] , oxo, [ka] , and independently selected from 5- to 9-membered heteroaryls, the 5- to 9-membered heteroaryls are at least one R 1* Replaced with R 1* is halogen, and C 1~6 Selected from alkyl groups. In some cases, R 1One or more substituents as needed may be chlorine, [ka] , oxo, [ka] It is selected independently of R. 1 teeth, [ka] Selected from.

[0189] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 These are selected from substituted 8- to 9-membered heterocycles as needed. In some cases, R 1 The complex ring of is [ka] [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 One or more substituents are halogens, C 1~6 Alkyl, -N(R 20 )2, and C 1~6 Selected from aminoalkyl groups. In some cases, R 1 teeth, [ka] Selected from.

[0190] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 It is selected from a bridged 8-membered heterocycle which is substituted as needed, and the heterocycle contains a heteroatom selected from nitrogen. In some cases, R 1One or more substituents of C 1~6 Alkyl, -N(R 20 )2, and C 1~6 Selected from aminoalkyl groups. In some cases, R 1 The complex ring of is [ka] Selected from, each of which is replaced as necessary. In some cases, R 1 teeth, [ka] Selected from. In some cases, R 1 teeth, [ka] In some cases, R 1 teeth, [ka] That is the case.

[0191] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 This is a 12- to 15-membered heteroring, substituted as needed. In some cases, R 1 This is a 12-membered heteroring with substitutions as needed. In some cases, R 1 This is a 13-membered heteroring with substitutions as needed. In some cases, R 1 This is a 14-membered heteroring with substitutions as needed. In some cases, R 1 This is a 15-membered heteroring with substitutions as needed. In some cases, R 1 The complex ring of is a triring. In some cases, R 1 The heterocycle of includes fused heterocycles. In some cases, R 1 The heterocycle of contains a spiroheterocycle. In some cases, R 1 The heterocycles include condensed and spiroheterocycles. In some cases, R 1The complex algebra of is an unsaturated complex algebra. In some cases, R 1 The heterocycle of is a non-aromatic heterocycle. In some cases, R 1 The heterocycle of has at least one double bond. In some cases, R 1 The heterocycle of has at least two double bonds. In some cases, R 1 The heterocycle has at least two heteroatoms. In some cases, R 1 The heterocycle has at least three heteroatoms. In some cases, R 1 The heterocycle has at least four heteroatoms. In some cases, R 1 The heterocycle has at least 5 heteroatoms. In some cases, R 1 The heterocycle has at least six heteroatoms. In some cases, R 1 The heterocycle has at least seven heteroatoms. In some cases, the heteroatoms are selected from oxygen, nitrogen, and sulfur. In some cases, R 1 The heterocycle has at least 3, 4, or 5 nitrogen atoms and at least 1 sulfur atom. In some cases, R 1 The heterocycle has at least 3, 4, or 5 nitrogen atoms and at least 1 oxygen atom. In some cases, R 1 The heterocycle has at least 3, 4, or 5 nitrogen atoms. In some cases, R 1 The heterocycle has at least 3, 4, or 5 nitrogen atoms and no other heteroatoms. In some cases, the heteroatoms are selected from nitrogen and sulfur. In some cases, the heteroatoms are selected from nitrogen and oxygen. In some cases, R 1 teeth, [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, R 1 teeth, [ka] Selected from, each of which is optionally substituted with one or more substituents. In some cases, R 1 One or more substituents as needed may be halogen, -OH, -NHCN, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, =NH, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C 2~6 It is selected independently of alkinyl. In some cases, R 1 One or more substituents as needed may be halogen, -OH, -NHCN, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 -NO2, =O, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C 2~6 It is selected independently of alkinyl. In some cases, R 1 One or more substituents as needed include halogen, -OH, and C. 1~6 Alkyl and -C(O)N(R 20)2 is selected independently. In some cases, R 1 teeth, [ka] Selected from.

[0192] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 This is a 12- to 15-membered heteroring, substituted as needed. In some cases, R 1 teeth, [ka] Ring W is a heterocycle which may be substituted as needed, and ring P is a heterocycle which may be substituted as needed, and ring P forms a spirocycle with ring W. In some cases, ring W is a fused heterocycle which may be substituted as needed. In some cases, rings P and W combine to form a heterocycle which has at least 12 atoms and up to 15 atoms. In some cases, rings P and W have at least 12 atoms and up to 15 atoms in total. In some cases, ring W is a 10-membered fused heterocycle which may be substituted as needed. In some cases, R 1 teeth, [ka] The ring P is a carbon ring or a hetero ring, if necessary. In some cases, R 1 teeth, [ka] In some cases, ring P is a carbon ring, optionally substituted. In some cases, ring P is a heterocycle, optionally substituted. In some cases, ring P forms an optionally substituted C3-C6 carbon ring or an optionally substituted 4-6 membered heterocycle. In some cases, ring P forms an optionally substituted C3 carbon ring. In some cases, ring P forms an optionally substituted C4 carbon ring. In some cases, ring P forms an optionally substituted C5 carbon ring. In some cases, ring P forms an optionally substituted 4-membered heterocycle. In some cases, ring P forms an optionally substituted 5-membered heterocycle. In some cases, ring P has at least 1, 2, or 3 heteroatoms. In some cases, the heteroatoms are selected from oxygen, nitrogen, and sulfur. In some cases, ring P has 1 sulfur atom. In some cases, ring P has 1 nitrogen atom. In some cases, ring P has 1 oxygen atom. In some cases, one or more optional substituents on ring P may be halogen, -OH, -NHCN, =O, =NR 20 ,-CN,C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C 2~6 The substituents are selected independently of the alkynyl group. In some cases, one or more optional substituents on ring P are halogens, -OH, =O, =NH, -CN, and C 1~6 Selected independently of alkyl. In some cases, one or more optional substituents on ring W may be halogen, -OH, -NHCN, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(O)NHOR 20 , -N(R 20)2, -C(O)R 20 -NO2, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, and C 2~6 Selected independently from alkynyls. In some cases, one or more optional substituents on ring W are halogens, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, -C(O)NHOR 20 , -N(R 20 )2, -C(O)R 20 , and C 1~6 Selected independently of alkyl. In some cases, one or more optional substituents on ring W are -C(O)R 20 They are selected independently. In some cases, ring P is substituted. In some cases, ring W is substituted.

[0193] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The saturated 6- to 7-membered heterocycle is selected as needed from the substituted ones. In some cases, R 1 It is selected from saturated six-membered heterocycles as needed. In some cases, R 1 teeth, [ka] Selected from these, which are substituted as needed. In some cases, one or more substituents as needed are halogen, -CN, -NHCN, C 1~6 Cyanoalkyl, and C 1~6Selected independently of alkyl. In some cases, one or more substituents as needed may be -CN, -NHCN, C 1~6 Cyanoalkyl, and C 1~6 Selected independently of alkyl. In some cases, one or more substituents as needed may be -CN, -NHCN, C 1~6 Cyanoalkyl, and C 1~6 Selected independently of alkyl. In some cases, one or more substituents as needed are -NHCN and C 1~6 Selected independently of alkyl. In some cases, R 1 teeth, [ka] Selected from, this is -NHCN, and C 1~6 It is substituted with one or more substituents selected from alkyl groups. In some cases, R 1 teeth, [ka] Selected from.

[0194] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 It is a bridging heterocycle. In some cases, R 1 It is selected from 7-10 membered bridged heterocycles. In some cases, R 1 It is selected from 8-membered bridged heterocycles. In some cases, R 1 The bridging heterocycle has at most one nitrogen atom. In some cases, R 1 The bridging heterocycle has a maximum of two nitrogen atoms. In some cases, R 1 The bridging heterocycle has at least two nitrogen atoms. In some cases, R 1 teeth, [ka] Selected from, which is replaced as needed. In some cases, R 1teeth, [ka] That is the case.

[0195] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The substituents as needed may be one or more halogens, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is selected independently of alkinyl. In some cases, R 1 The substituents as needed may be one or more halogens, -B(OR 20 )2, -OR 20, -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is selected independently of alkinil.

[0196] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The substituents as needed may be one or more halogens, -B(OR 20 )2, -OH, -OC 1~6 Alkyl, -SR 20 , -N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, R 1 The substituents as needed may be one or more halogens, -B(OR 20 )2, -OH, -SR 20 , -N(R 20 )2, -NO2, =NO(R 20 ), C 1~6 Alkoxyalkyl, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, R 1 The substituents as needed include one or more halogens, -OH, -NH2, and C 1~6 Selected independently of alkoxy. In some cases, R 1 The substituents as needed include one or more halogens, -OH, and C 1~6 Selected independently of alkoxy. In some cases, R 1 The substituents as needed are selected independently from one or more halogens and -OH groups. In some cases, R 1 The substituents as needed are independently selected from one or more -OH groups. In some cases, R 1 The substituents as needed are one or more C 1~6 Alkyl, C 1~6 Selected independently from hydroxyalkyl and -OH. In some cases, R 1 The substituents as needed are one or more C 1~6 Selected independently from hydroxyalkyl and -OH. In some cases, R 1 C 1~6 It is substituted with at least one substituent independently selected from hydroxyalkyl and -OH. In some cases, R 1 It is substituted with at least one substituent independently selected from -OH.

[0197] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The heterocycle is substituted with one or more substituents. In some cases, R 1 The substituents are one or more halogens, -B(OR 20 )2, -OH, -OC 1~6 Alkyl, -SR 20 , -N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, R 1 The substituents are one or more halogens, -B(OR 20 )2, -OH, -SR 20 , -N(R 20 )2, -NO2, =NO(R 20 ), C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Haloalkyl and C 1~6 Selected independently of alkyl. In some cases, R 1 The substituents are one or more halogens, -OH, -NH2, and C 1~6 Selected independently of alkoxy. In some cases, R 1 The substituents are one or more halogens, -OH, and C 1~6 Selected independently of alkoxy. In some cases, R 1 The substituents as needed are selected independently of one or more halogens and -OH groups.

[0198] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1The heterocycle is substituted with one or more substituents. In some cases, R 1 The heterocycle of is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 Alkoxyalkyl, C 2~6 Alkenyl and C 2~6 Substituted with one or more substituents selected from alkynyl; C 1~6 Alkoxyalkyl, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl and C 1~6 It is further optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 The substituents are one or more halogens, -OR 20 , -SR 20 , -N(R 20 )2, -NHCN, -NO2, =O, -CN, C 1~6 Fluoroalkyl, and C 2~6 Each is selected from alkinyl;-C(O)N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Alkyl, and C 2~6It is further optionally substituted with one or more substituents independently selected from the alkenyl. In some cases, R 1 The substituents are one or more halogens, -OR 20 , -N(R 20 )2, -NHCN, =O, -CN, and C 2~6 Each is selected from alkinyl;-C(O)N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, and C 1~6 It is further optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 The substituents are one or more halogens, -OH, -NHCN, =O, -CN, and C 2~6 Each is selected from Alkinil; C 1~6 It is further optionally substituted with one or more substituents independently selected from the alkyl group. In some cases, R 1 The substituents are selected from one or more halogens, NH2, -OH, and =O, respectively.

[0199] In some embodiments, for a compound or salt of formula (I), R 100 YR 2 It is different. In some cases, [ka] YR 2 It is different.

[0200] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), L is selected from C1 to C4 alkylenes. In some cases, L is selected from C1 to C2 alkylenes. In some cases, L is selected from C1 alkylenes.

[0201] In some embodiments, for compounds or salts of formula (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (II), or (IJ), L is selected from unsubstituted C1-C4 alkylenes. In some cases, L is selected from unsubstituted C1-C2 alkylenes. In some cases, L is selected from unsubstituted C1 alkylenes. In some cases, L is selected from methylene and ethylene. In some cases, L is methylene.

[0202] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 -L-heterocycles as needed, -L-heteroaryls as needed, -L-aryls as needed, -LN(R 5 )2, and -LOR 5 Selected from. In some cases, R 2 These are -L-5~12 member heterocycles as needed, -L-5~12 member heteroaryls as needed, and -L-C6~C as needed. 12 Ariel, -LN(R 5 )2, and -LOR 5 Selected from. In some cases, R 2 These are -L-heterocycles as needed, -L-heteroaryls as needed, and -LN(R 5 ) Selected from 2. In some cases, R 2 These are -L-5~12 member heterocycles as needed, -L-5~12 member heteroaryls as needed, and -LN(R 5 ) Selected from 2. In some cases, R 2 These are the -L-heterogenes and -LN(R) which are substituted as needed. 5 ) Selected from 2. In some cases, R 2 These are -L-5~12 membered heterocycles and -LN(R) as needed.5 ) Selected from 2. In some cases, R 2 It is selected from the -L-5~12 membered complex rings as needed. In some cases, R 2 It is selected from the -L-5~12 member saturated hetero rings as needed. In some cases, R 2 The heterocycle is selected from substituted -L-heterocycles as needed. In some cases, the heterocycle is selected from pyrrolidine, hexahydro-1H-pyrrolidine, pyrazolidine, imidazolidine, tetrahydrofuran, piperidine, piperazine, morpholine, azocane, and azonane. In some cases, the heterocycle is selected from cyclic sulfonamides. In some cases, the heterocycle is selected from pyrrolidine, hexahydro-1H-pyrrolidine, pyrazolidine, imidazolidine, piperidine, piperazine, azocane, and azonane. In some cases, the heteroaryl is selected from pyrrole, pyrazole, furan, thiophene, oxazole, isoxazole, isothiazole, thiazole, pyridine, pyrazine, and triazine. In some cases, the heteroaryl or heterocycle has at most one nitrogen atom. In some cases, the heteroaryl or heterocycle has at least one nitrogen atom. In some cases, heteroaryl or heterocyclic rings have one nitrogen atom.

[0203] In some embodiments, for compounds or salts of formula (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (II), or (IJ), L is selected from C1-C4 alkylenes. In some cases, L is selected from unsubstituted C1-C4 alkylenes. In some cases, L is selected from unsubstituted C1 alkylenes. In some cases, two substituents on the same carbon atom of L combine to form a C3-C6 carbocyclic ring or a 3-8 membered heterocyclic ring, and the C3-C6 carbocyclic ring and the 3-8 membered heterocyclic ring are halogens, -OH, -NO2, =O, =S, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C1~6 The haloalkyl group is optionally substituted with one or more substituents independently selected from the haloalkyl group. In some cases, two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle. In some cases, two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring.

[0204] In some embodiments, for compounds or salts of formula (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (II), or (IJ), L is selected from C1-C4 alkylenes. In some cases, L is selected from unsubstituted C1-C4 alkylenes. In some cases, each L is independently selected from optionally substituted C1-C4 alkylenes; optionally, two substituents on the same carbon atom of L combine to form a C3-C6 carbocyclic or 3-8 membered heterocyclic ring, where C3-C6 carbocyclic and 3-8 membered heterocyclic rings are halogens, -OH, -NO2, =O, =S, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Each L is optionally substituted with one or more substituents selected from haloalkyl groups. In some cases, the optional substituents of L are selected from C1-C4 hydroxyalkyl groups, C1-C4 alkyl groups, and C3-C6 carbon rings; optionally, two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon rings and 3-8 membered heterocycles are halogens and C 1~6 It is optionally substituted with one or more substituents selected from haloalkyl groups. In some cases, L is [ka] Selected from. In some cases, L is [ka] Selected from. In some cases, each L is independently selected from substituted C1-C4 alkylenes, and the two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring, a 3-5 membered heterocycle. In some cases, each L is substituted C 2~3 Independently selected from alkylenes, two substituents on the same carbon atom of L combine to form a C3 carbon ring or a 4-membered heterocycle, and the C3 carbon ring is optionally substituted with one or more substituents selected from halogens. In some cases, each L is [ka] It is selected independently of the others. In some cases, each L is [ka] It is selected independently of the others. In some cases, each L is [ka] Independently selected from. In some cases, each L is independently selected from C1-C4 alkylenes optionally substituted with one or more substituents independently selected from halogens and C1-C4 alkyls. In some cases, L is [ka] Selected from.

[0205] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), each L is independently selected from unsubstituted C1-C4 alkylenes. In some cases, L is [ka] Selected from. In some cases, L is [ka] Selected from.

[0206] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 These are heterocycles, C1-C6 alkyl groups, -L-heterocycles, and -LN(R) 20 )2, -L-OR 20 -L-aryl, -L-heteroaryl, -L-cycloalkyl, -LN(R 20 )2, -L-NHC(=NH)NH2, -LC(O)N(R 20 )2, -L-C1~C6 haloalkyl, -L-OR 20 , -L-NR 20 C(O)-aryl, -L-COOH, -L-NR 20 S(O)2(R 20 ), -LS(O)2N(R 20 )2, -LN(R 20 )C(O)(OR 20 ), -L-OC(O)N(R 20 )2, and selected from -LC(=O)OC1~C6 alkyl, the heterocycle, the heterocyclic moiety of the -L-heterocycle, and the cycloalkyl moiety of the -L-cycloalkyl are one or more R 6 These are replaced as needed, -L-NR 20 C(O)-aryl part, -L-NR 20 The aryl portion of C(O)-aryl, the aryl portion of -L-aryl, and the heteroaryl portion of -L-heteroaryl are one or more R 7 Each is replaced as needed.

[0207] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2These are heterocycles, -L-heterocycles, -L-aryls, -L-heteroaryls, and -LN(R 20 ) Selected from 2, the heterocyclic part of the heterocyclic algebra, -L-heterocyclic algebra, is one or more R 6 Each is substituted as needed, and the aryl in -L-aryl and the heteroaryl in -L-heteroaryl are one or more R 7 Each is replaced as needed.

[0208] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 is a heteroalgebra, -L-heteroalgebra, -LN(R 20 )2, -L-OR 20 -L-aryl, -L-heteroaryl, -L-cycloalkyl, -L-NHC(=NH)NH2, -LC(O)N(R 20 )2, -L-C1~C6 haloalkyl, -L-NR 20 C(O)-aryl, -L-COOH, -L-NR 20 S(O)2(R 20 ), -LS(O)2N(R 20 )2, -LN(R 20 )C(O)(OR 20 ), -L-OC(O)N(R 20 )2, and selected from -LC(=O)OC1~C6 alkyl, the heterocycle, the heterocyclic moiety of the -L-heterocycle, and the cycloalkyl moiety of the -L-cycloalkyl are one or more R 6 These are replaced as needed, -L-NR 20 The aryl portion of C(O)-aryl, the aryl portion of -L-aryl, and the heteroaryl portion of -L-heteroaryl are one or more R 7 Each is substituted as necessary; the heterocycle, the heterocyclic moiety of the -L-heterocycle, and the heteroaryl of the -L-heteroaryl each have at least one heteroatom selected from nitrogen, oxygen, silicon, and sulfur.

[0209] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 It is a -L-heterogenetic ring, and the heterogenetic ring portion is substituted as needed. In some cases, R 2 It is an L-complex ring, and the complex ring portion is a biring complex ring. In some cases, R 2 It is a -L-heterogenetic ring, and the heterogenetic ring portion is a monoring heterogenetic ring. In some cases, R 2 It is a -L-heterogenetic ring, and the heterogenetic part is a saturated heterogenetic ring. In some cases, R 2 It is selected from the -L-5 to 10-membered complex rings. In some cases, R 2 The compound is selected from -(C1~C2 alkylene)-5~10 membered heterorings. In some cases, R 2 It is selected from the -L-5 to 8-membered complex rings. In some cases, R 2 It is selected from the -L-5 to 8-membered saturated hetero rings. In some cases, R 2 It is a -L-5 member complex ring. In some cases, R 2 It is an -L-8 membered heterocycle. In some cases, the heterocycle contains at least one nitrogen atom. In some cases, the heterocycle contains up to one nitrogen atom. In some cases, the heterocycle contains one nitrogen atom. In some cases, the bicyclic heterocycle contains at least one nitrogen atom. In some cases, the heterocycle has a silicon atom. In some cases, the bicyclic heterocycle contains up to one nitrogen atom. In some cases, the bicyclic heterocycle contains one nitrogen atom. In some cases, YR 2 teeth, [ka] Selected from, the complex ring portion is substituted as needed. In some cases, YR 2 teeth, [ka] The heterocyclic portion is selected from and substituted as necessary. In some cases, the heterocyclic portion is optionally substituted with one or more substituents selected from halogens, hydroxy, C1-C3 hydroxyalkyl, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, -CN, and C1-C3 aminoalkyl. In some cases, the heterocyclic portion is optionally substituted with one or more substituents selected from halogens, hydroxy, -CN, C1-C3 hydroxyalkyl, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, and C1-C3 aminoalkyl. In some cases, the heterocyclic portion is optionally substituted with one or more substituents selected from C1-C3 alkyl and halogen. In some cases, YR 2 teeth, [ka] Selected from. In some cases, YR 2 teeth, [ka] Selected from. In some cases, YR 2 teeth, [ka] Selected from. In some cases, YR 2 teeth, [ka] That is the case.

[0210] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2The heterocycle is selected from substituted -L-heterocycles as needed. In some cases, the heterocycle is a monocyclic heterocycle. In some cases, the heterocycle has only one nitrogen atom. In some cases, the heterocycle has only one nitrogen atom and no other heteroatoms. In some cases, YR 2 teeth, [ka] Selected from, this is one or more R 6 It is replaced as needed. In some cases, each R 6 These include halogens, C1-C3 hydroxyalkyls, C1-C3 alkyls, C1-C3 haloalkyls, (C1-C3 alkoxy)C1-C3 alkyl-, and C 1~6 alkyl-N(R 20 ) Selected independently from 2. In some cases, YR 2 teeth, [ka] Selected from.

[0211] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 The heterocycle is selected from substituted -L-heterocycles as needed. In some cases, the heterocycle is a bicyclic heterocycle. In some cases, the heterocycle is a monocyclic heterocycle. In some cases, the heterocycle has only one nitrogen atom. In some cases, the heterocycle has only one nitrogen atom and no other heteroatoms. In some cases, YR 2 teeth, [ka] Selected from, the complex ring portion is substituted as needed. In some cases, YR 2 teeth, [ka] Selected from, the complex ring portion is substituted as needed. In some cases, YR 2 teeth, [ka] Selected from, the complex ring portion is substituted as needed. In some cases, YR 2 teeth, [ka] Selected from the above, the heterocyclic portion is substituted as needed. In some cases, the heterocyclic portion is halogen, hydroxyl, C1-C3 alkyl, -N(R) 5 )S(O)2(R 5 ), -OC(O)N(R 5 )2, oxo, =CH2, =NO-C1~C3 alkyl, -CH2OC(O) heterocycle, -CH2 heterocycle, -CH2OC(O)N(R 5 )2, and optionally substituted with one or more substituents selected from -O-C1~C3 alkyl groups, where the alkyl of the -O-C1~C3 alkyl group is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups. In some cases, YR 2 teeth, [ka] Selected from. In some cases, YR 2 teeth, [ka] Selected from. In some cases, YR 2 teeth, [ka] [ka] Selected from.

[0212] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 It is a -L-heteroaryl compound, and the heteroaryl portion consists of one or more R 7 Substitutions are made as needed. In some cases, the heteroaryl has at least one nitrogen atom. In some cases, the heteroaryl has two nitrogen atoms. In some cases, the heteroaryl is [ka] And this is substituted as needed. In some cases, heteroaryls are [ka] And this is substituted as needed. In some cases, heteroaryls are [ka] This is replaced as needed. In some cases, YR 2 teeth, [ka] Selected from, the heteroaryl portion consists of one or more R 7 It is replaced as needed. In some cases, each R 7 The C1-C4 alkyl, halogen, and C1-C4 haloalkyl elements are independently selected. In some cases, YR 2 teeth, [ka] Selected from. In some cases, YR 2 teeth, [ka] Selected from.

[0213] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 is one or more R 7 It is a -L-aryl that is substituted as needed. In some cases, YR 2 teeth, [ka] Selected from, the complex ring portion is one or more R 7 It is replaced as needed. In some cases, YR 2 teeth, [ka] Selected from.

[0214] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 -LN(R 20 )2. In some cases, YR 2 teeth, [ka] Selected from.

[0215] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 is one or more R 6 It is a complex ring that has been substituted as needed. In some cases, R 6 The complex ring of is [ka] And this is replaced as needed. In some cases, R 6 The complex ring of is [ka] In some cases, YR 2 teeth, [ka] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), YR 2 teeth, [ka] Selected from, the heterocyclic portion is substituted as needed, and one or more substituents as needed are halogen, hydroxyl, C1-C3 alkyl, -N(R 5 )S(O)2(R 5 ), -OC(O)N(R 5 )2, =CH2, oxo, =NO-C1~C3 alkyl, -CH2OC(O) heterocycle, -CH2 heterocycle, -CH2OC(O)N(R 5 )2, -(CH2) 0~1 -O-heterocyclic and -O-C1~C3 alkyl groups are selected, and the alkyl group of the -O-C1~C3 alkyl group is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups, and -(CH2) 0~1 The complex algebra of an O-complex algebra is C 1~6 Alkyl, C 1~6 Haloalkyl, C 1~6 Alkyl-OR 20 , and -OR 20 It is optionally substituted with one or more substituents selected from the following. In some cases, one or more substituents as needed are [ka] Selected from.

[0216] In some embodiments, for a compound or salt of formula (I), formula (I-A), formula (I-B), formula (I-C), formula (I-D), formula (I-E), formula (I-F), formula (I-G), formula (I-H), formula (I-I) or formula (I-J), Y-R 2 is

Chemical formula

Chemical formula

Chemical formula

[0217] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 is a heterocycle, an -L-heterocycle (where the heterocycle portion of the heterocycle and the -L-heterocycle is one or more R 6 (where the aryl in -L-aryl and the heteroaryl in -L-heteroaryl are replaced as needed); -L-aryl and -L-heteroaryl (where the aryl in -L-aryl and the heteroaryl in -L-heteroaryl are one or more R 7 Each is replaced as needed); and -LN(R 20 ) Selected from 2. In some cases, R 2 The complex ring of is [ka] Selected from, R 2 The complex ring of is one or more R 6 Replaced as needed; R 2 The aryl and heteroaryl compounds are [ka] Selected from, aryls and heteroaryls are one or more R 7 and [ka] Each is replaced as needed. In some cases, R 2 The complex ring of is [ka] [ka] Selected from, the complex ring is one or more R 6 Replaced as needed; R 2 The aryl and heteroaryl compounds are [ka] Selected from, aryls and heteroaryls are one or more R 7 and [ka] Each is replaced as needed. In some cases, each R 6 These are halogens, hydroxyls, C1-C3 alkyls, C1-C3 haloalkyls, and -N(R) 5 )S(O)2(R 5 ), -OC(O)N(R 5 )2, =CH2, oxo, =NO-C1~C3 alkyl, -CH2OC(O) heterocycle, -CH2 heterocycle, -CH2OC(O)N(R 5 )2, and independently selected from -O-C1~C3 alkyl groups, where the alkyl group of the -O-C1~C3 alkyl group is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups; each R 7 The C1-C3 alkyl, halogen, and C1-C3 haloalkyl are selected. In some cases, R 2 The complex algebra of R 2 Aryl and heteroaryl forms of, as well as R 2 -N(R 20 )2 is, [ka] [ka] Selected from. In some cases, YR 2 teeth, [ka] (In the formula, the heterocyclic portion of the heterocyclic ring and the heterocyclic portion of the -L-heterocyclic ring is one or more R 6 Each is replaced as needed); [ka] (In the formula, the aryl in -L-aryl and the heteroaryl in -L-heteroaryl are one or more R 7 Each is replaced as needed); and [ka] Selected from. In some cases, YR 2 teeth, [ka] [ka] [ka] Selected from. In some cases, YR 2 teeth, [ka] Selected from.

[0218] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), L is independently selected from C1-C4 alkylenes optionally substituted with one or more substituents independently selected from hydroxy, C1-C4 hydroxyalkyl, and C1-C4 alkyl groups. In some cases, L is independently selected from C1-C4 alkylenes optionally substituted with one or more substituents independently selected from C1-C4 alkyl groups. In some cases, L is selected from C1-C4 alkylenes. In some cases, L is selected from C1-C2 alkylenes. In some cases, L is, [ka] In some cases, L is [ka] That is the case.

[0219] In some embodiments, for compounds or salts of formula (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (II), or (IJ), each L is independently selected from optionally substituted C1-C4 alkylenes; optionally, two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring, where the C3-C6 carbon ring is halogen, -OH, -NO2, =O, =S, -CN, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6It is optionally substituted with one or more substituents selected from haloalkyls. In some cases, the optional substituents of L are selected from C1-C4 hydroxyalkyl, C1-C4 alkyl, and C3-C6 carbon rings; optionally, two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and 3-8 membered heterocycle are halogen and C 1~6 They are optionally substituted with one or more substituents selected from haloalkyl groups.

[0220] In some embodiments, for compounds or salts of formula (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (II), or (IJ), each L is independently selected from substituted C1-C4 alkylenes, and two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring. In some cases, the C3-C6 carbon ring consists of halogens, -OH, -NO2, =O, =S, -CN, and C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 They are optionally substituted with one or more substituents selected from haloalkyl groups.

[0221] In some embodiments, for compounds or salts of formula (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (II), or (IJ), each L is independently selected from substituted C1-C4 alkylenes, and two substituents on the same carbon atom of L combine to form a C3-C6 carbon ring. In some cases, each L is independently selected from substituted C3 alkylenes, and two substituents on the same carbon atom of L combine to form a C3 carbon ring. In some cases, each L is, [ka] It is selected independently of others.

[0222] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 is selected from the -L-heterogenetic rings, and the heterogenetic portion of the -L-heterogenetic ring is one or more R 6 Substitutions are made as necessary. In some cases, the heterocycle is a saturated heterocycle. In some cases, the heterocycle has at least one nitrogen atom and at least one sulfur atom. In some cases, the heterocycle has at least one nitrogen atom. In some cases, the heterocycle has at least one sulfur atom.

[0223] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 teeth, [ka] Selected from, the complex ring portion is one or more R 6 It is replaced as needed.

[0224] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), YR 2 teeth, [ka] Selected from, the complex ring portion is one or more R 6 It is replaced as needed.

[0225] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), YR 2 teeth, [ka] Selected from, the complex ring portion is one or more R 6 It is replaced as needed.

[0226] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), YR 2 teeth, [ka] Selected from, the complex ring portion is one or more R 6 It is replaced as needed.

[0227] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 is selected from -L-saturated heterocycles, and the saturated heterocycle portion of the -L-saturated heterocycle is one or more R 6 It is substituted as needed and contains one nitrogen atom and one sulfur atom. In some cases, YR 2 teeth, [ka] Selected from, the complex ring portion is one or more R 6 It is replaced as needed. In some cases, YR 2 teeth, [ka] Selected from, the heterocyclic portion is optionally substituted with one or more substituents selected from C1-C3 alkyl and oxo. In some cases, YR 2 teeth, [ka] Selected from. In some cases, YR 2 teeth, [ka] Selected from.

[0228] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), each R 6 These are halogens, -OH, C1-C3 hydroxyalkyl, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, -CN, C1-C3 aminoalkyl, -Q-phenyl, -Q-phenylSO2F, -NHC(O)phenyl, -NHC(O)phenylSO2F, C1-C3 alkyl-substituted pyrazolyl, -N(R 5 )2, (C1~C3 alkoxy)C1~C3 alkyl-, (C1~C3 alkyl)C(=O), oxo, (C1~C3 haloalkyl)C(=O)-, -SO2F, (C1~C3 alkoxy)C1~C3 alkoxy, -CH2OC(O)N(R 5 )2,-CH2NHC(O)OC1~C6 alkyl,-CH2NHC(O)N(R 5 )2, -CH2NHC(O)C1~C6 alkyl, -CH2(pyrazolyl), -CH2NHSO2C1~C6 alkyl, -CH2OC(O) heterocycle, -OC(O)N(R 5)2, -OC(O)NH(C1~C3alkyl)O(C1~C3alkyl), -OC(O)NH(C1~C3alkyl)O(C1~C3alkyl)phenyl(C1~C3alkyl)N(CH3)2, -OC(O)NH(C1~C3alkyl)O(C1~C3alkyl)phenyl, -OC(O) heterocycle, and -CH2 heterocycle are independently selected, and the phenyl in -NHC(O)phenyl and -OC(O)NH(C1~C3alkyl)(C1~C3alkyl)phenyl are optionally substituted with -C(O)H and OH, respectively, and the heterocycle of the -CH2 heterocyclil is optionally substituted with oxo.

[0229] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), each R 6 The element is independently selected from halogen, -OH, C1-C3 hydroxyalkyl, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, -CN, and C1-C3 aminoalkyl.

[0230] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), each R 6 These include halogens, -OH, C1-C3 hydroxyalkyl, C1-C3 alkyl, C1-C3 aminoalkyl, C1-C3 haloalkyl, C1-C3 alkoxy, and -N(R 5 )2, and are selected independently from the oxo. In some cases, each R 6 These include -OH, C1-C3 hydroxyalkyl, C1-C3 alkyl, C1-C3 aminoalkyl, C1-C3 alkoxy, and -N(R 5 )2 is selected independently. In some cases, each R 6 These are C1-C3 alkyl, C1-C3 alkoxy, and -N(R 5)2 is selected independently. In some cases, each R 6 These are halogens, hydroxyls, C1-C3 alkyls, C1-C3 haloalkyls, and -N(R) 5 )S(O)2(R 5 ), -OC(O)N(R 5 )2, =CH2, oxo, =NO-C1~C3 alkyl, -CH2OC(O) heterocycle, -CH2 heterocycle, -CH2OC(O)N(R 5 )2, and independently selected from -O-C1~C3 alkyl groups, where the alkyl group of the -O-C1~C3 alkyl group is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups; each R 7 The C1-C3 alkyl group is selected from C1-C3 alkyl groups, halogens, and C1-C3 haloalkyl groups.

[0231] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 6 The elements are selected from halogens, -OH, C1-C3 hydroxyalkyl, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, -CN, and C1-C3 aminoalkyl. In some cases, R 6 The halogen is selected from halogens and C1-C3 alkyl groups. In some cases, R 6 It is a halogen. In some cases, R 6 These are C1-C3 alkyl groups. In some cases, R 6 The halogen is selected from halogens and C1-C3 alkyl groups. In some cases, R 6 It is selected from methyl and fluorine.

[0232] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 teeth, [ka] Selected from.

[0233] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), YR 2 teeth, [ka] Selected from.

[0234] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), YR 2 teeth, [ka] Selected from.

[0235] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), YR 2 teeth, [ka] That is the case.

[0236] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), L is selected from unsubstituted C1-C4 alkylenes.

[0237] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), YR 2 teeth, [ka] Selected from, the complex ring portion is one or more R 6 It is replaced as needed.

[0238] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 R 6 Each of these is independently selected from halogen, hydroxy, C1-C3 hydroxyalkyl, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, cyano, and C1-C3 aminoalkyl.

[0239] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), R 2 R 6 Each of these is independently selected from C1-C3 alkyl groups and halogens.

[0240] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), formula (ID), formula (IE), formula (IF), formula (IG), formula (IH), formula (II), or formula (IJ), YR 2 teeth, [ka] Selected from.

[0241] In some embodiments, for compounds or salts of formula (I), formula (IA), formula (IB), formula (IC), or formula (IG), R 1 The heterocycle is substituted with at least one halogen. In some cases, R 1 The complex ring of is -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -C(O)N(R 20 )2, and -C(O)NHOR 20 It is substituted with at least one substituent selected from. In some cases, R 1 The complex algebra of is at least one C 1~6 alkyl-N(R 20 ) is replaced with 2.

[0242] In some embodiments, formula (I) is expressed as formula (IC * It is represented by ).

[0243] In some aspects, this disclosure relates to formula (IC * ) compounds: [ka] or a pharmaceutically acceptable salt thereof [in the formula, R 1A C 1~6 Alkyl, C3~C 12 Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R 11 Replaced as needed, R 1A Two R on the same atom 11 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 11A Each is replaced as needed; R 1B is hydrogen, C 1~6 Selected from alkyl, C3-C6 carbon rings, and 4-6 membered heterocycles, C 1~6Alkyl, C3-C6 carbon rings, and 4-6 membered heterocycles are one or more R 10 Are they replaced as needed? Or R 1A and R 1B Together with the atoms they bond to, R 1 Forms R 1 It is a 5-15 member heterocycle, and 5-15 member heterocycles are halogens, -B(OR 20 )2, -N(R 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(=NR 20 )N(R 20 )2, -C 1~6 Alkyl (=NR) 20 Ure 20 ), -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl-SO2R20 , C 1~6 Alkoxyalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Optionally substituted with one or more substituents independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles contain one or more R 1* They are independently replaced as needed; Each R 1* is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6Alkenil, C 2~6 Alkinyl, and C3~C 12 Selected independently from the carbon ring; Y is -O-; R 2 is a heteroalgebra, -L-heteroalgebra, -LN(R 20 )2, -L-OR 20 -L-aryl, -L-heteroaryl, -L-cycloalkyl, -L-NHC(=NH)NH2, -LC(O)N(R 20 )2, -L-C1~C6 haloalkyl, -L-NR 20 C(O)-aryl, -L-COOH, -L-NR 20 S(O)2(R 20 ), -LS(O)2N(R 20 )2, -LN(R 20 )C(O)(OR 20 ), -L-OC(O)N(R 20 )2, and selected from -LC(=O)OC1~C6 alkyl, the heterocycle, the heterocyclic moiety of the -L-heterocycle, and the cycloalkyl moiety of the -L-cycloalkyl are one or more R 6 These are replaced as needed, -L-NR 20 The aryl portion of C(O)-aryl, the aryl portion of -L-aryl, and the heteroaryl portion of -L-heteroaryl are one or more R 7 Each is replaced as needed; Each L stands for halogen, hydroxyl, and C. 1~6 Independently selected from C1-C4 alkylenes optionally substituted with one or more substituents independently selected from alkoxy, C1-C4 hydroxyalkyl, C1-C4 alkyl, C3-C6 carbon rings, and 3-8 membered heterocycles, wherein the C3-C6 carbon rings and 3-8 membered heterocycles are halogens, -OH, -NO2, =O, =S, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6Each is optionally substituted with one or more substituents independently selected from the haloalkyl group; optionally, two substituents on the same carbon atom of L may combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, where the C3-C6 carbon ring and 3-8 membered heterocycle are halogen, -OH, -NO2, =O, =S, -CN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, and C 1~6 Each substituent is optionally substituted with one or more substituents independently selected from the haloalkyl group; Each R 5 These are independently selected from hydrogen and C1-C6 alkyl groups; Each R 6 Halogen, hydroxy, C1-C3 hydroxyalkyl, C1-C3 alkyl, oxo, C1-C3 haloalkyl, C1-C3 alkyl-N3, C1-C3 alkoxy, cyano, =CH2, =NO-C1-C3 alkyl, C1-C3 aminoalkyl, -N(R) 5 )S(O)2(R 5 ), -Q-phenyl, -Q-phenylSO2F, -NHC(O)phenyl, -NHC(O)phenylSO2F, C1~C3 alkyl-substituted pyrazolyl, tert-butyldimethylsilyloxyCH2-, -N(R 5 )2, (C1~C3 alkoxy)C1~C3 alkyl-, (C1~C3 alkyl)C(=O), oxo, (C1~C3 haloalkyl)C(=O)-, -SO2F, (C1~C3 alkoxy)C1~C3 alkoxy, -CH2OC(O)NCF3(R 5 ), -CH2O-C1~C6 alkyl, -CH2OC(O)N(R 5 )2,-CH2NHC(O)OC1~C6 alkyl,-CH2NHC(O)N(R 5 )2, -CH2NHC(O)C1~C6 alkyl, -CH2(pyrazolyl), -CH2NHSO2C1~C6 alkyl, -CH2OC(O) heterocycle, -OC(O)N(R 5)2,-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl),-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl)phenyl(C1~C3alkyl)N(CH3)2,-OC(O)NH(C1~C3alkyl)O(C1~C3alkyl)phenyl,-OC(O)heterocycle,-O-C1~C3alkyl,-O-C1~C6 haloalkyl,-C1~C3alkyl-O-C1~C6 haloalkyl,C 1~6 alkyl-N(R 20 )2, -SF5, -C1~C3 alkyl-N3, -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-(CH2) 0~1 S-heterogenetic algebra, -(CH2) 0~1 -O-heterogenetic ring, -(CH2) 0~1 -O-phenyl and -CH2 heterocycles are independently selected, The phenyl group in -NHC(O)phenyl and -OC(O)NH(C1~C3alkyl)(C1~C3alkyl)phenyl is optionally substituted with one or more substituents selected from -C(O)H and OH. -O-C1~C3 alkyl groups are optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups; The alkyl group of -CH2O-C1~C6 alkyl is optionally substituted with one or more substituents selected from halogens and C3~C6 carbon rings; The heterocycle of the -CH2 heterocycle is substituted with oxos as needed; -(CH2) 0~1 -O-phenyl is C 1~6 Alkyl, C 1~6 Haloalkyl, SF5, C 1~6 Alkyl-OR 20 , -OR 20 Replaced as needed with one or more substituents selected from; -(CH2) 0~1-O-heterogenetic rings and -(CH2) 0~1 The complex algebra of the -S- complex algebra is C 1~6 Alkyl, C 1~6 Haloalkyl, C 1~6 Alkyl-OR 20 , and -OR 20 Each of these substituents is optionally replaced by one or more substituents selected from the following; Each Q is selected from joins and O; Each R 7 These include halogens, hydroxyls, HC(=O)-, C1-C4 alkyls, C1-C4 alkoxys, C1-C4 haloalkyls, C1-C4 hydroxyalkyls, and -N(R) 5 ) Selected independently from 2; B is a 7-15 member heterocycle and C7-C 15 Selected from carbon rings, 7-15 membered heterocycles and C7-C 15 The carbon ring is a halogen, -CN, -NO2, =O, -N(R) 20 )2, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Alkoxyalkyl, C 1~6 Hydroxyalkyl, C1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Each is optionally substituted with one or more substituents independently selected from the carbocyclic and 5- to 12-membered heterocycles; Each R 10 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12 Independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12Carbon rings and 5-12 membered heterocycles are halogens, -OH, -CN, -NO2, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Each substituent is optionally substituted with one or more substituents independently selected from alkyl and oxo; Each R 11 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NR 20 (C=NH)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C3~C 12Independently selected from carbon rings and 5-12 membered heterocycles, C3-C 12 Carbon rings and 5-12 membered heterocycles are halogens, -OH, -CN, -NO2, -N(R) 21 )2, -SR 21 ,-C(O)N(R 21 )2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Alkyl, -S(O)2(R 21 ), -P(O)(OR 21 )2, -OP(O)(OR 21 )2, -P(O)(R 21 )2, and each as needed, substituted with one or more substituents independently selected from the oxo; Each R 11A is halogen, -B(OR 20 )2, -OR 20 , -SR 20 -S(O)2(R 20 ), -S(O)2N(R 20 )2, -S(O)N(R 20 )2, -S(O)R 20 (=NR 20 ), -NR 20 S(O)2R 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)N(R 20 )2, -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Selected independently of Alkinnir; Each R 20 hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2, C 1~10 Alkyl, C 1~10 Haloalkyl, -OC 1~10 Alkyl, oxo, C 3~12 C as needed, substituted with one or more substituents independently selected from carbocyclic and 3- to 12-membered heterocycles. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~12 Independently selected from carbon rings and 3- to 12-membered heterocycles; Each R 21 hydrogen; and each of them is a halogen, -OH, -CN, -NO2, -NH2, -N(C) 1~6 Alkyl)2, C 1~10 Alkyl, -C 1~10 Haloalkyl, -OC 1~10 Alkyl, oxo, C 3~12 C as needed, substituted with one or more substituents independently selected from carbocyclic and 3- to 12-membered heterocycles. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~12 [Independently selected from carbon rings and 3- to 12-membered heterocycles] To provide.

[0244] In some embodiments, formula (I) or formula (IC * For compounds or salts of ) R 1A C 1~3 Selected from alkyl, C3-C9 carbon rings, and 4-8 membered heterocycles, each of which has one or more R 11 Replaced as needed, R 1ATwo R on the same atom 11 These combine to form a C3-C6 carbon ring or a 3-8 membered heterocycle, and the C3-C6 carbon ring and the 3-8 membered heterocycle have one or more R 11A Each is replaced as needed; R 1B is hydrogen, C 1~3 Selected from alkyl, C3-C5 carbon rings, and 4-6 membered heterocycles, C 1~6 Alkyl, C3-C6 carbon rings, and 4-6 membered heterocycles are one or more R 10 Are they replaced as needed? Or R 1A and R 1B Together with the atoms they bond to, R 1 Forms R 1 These are 5- to 9-membered heterocyclic rings, and 5- to 9-membered heterocyclic rings include halogens, -B(OR 20 )2, -N(R 20 )2, -OR 20 , -SR 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)OR 20 , -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkoxyalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6The alkynyl ring is optionally substituted with one or more substituents independently selected from C3-C6 carbon rings and 5-7 membered heterocycles, where the C3-C6 carbon rings and 5-7 membered heterocycles are substituted with one or more R 1* They are independently substituted as needed; each R 1* is halogen, -B(OR 20 )2, -OR 20 , -SR 20 ,-C(O)N(R 20 )2, -C(O)NR 20 Ure 20 , -N(R 20 )C(O)R 20 , -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =N(R 20 ), =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkynyl and C3-C6 carbon rings are independently selected; B is selected from 7- to 9-membered heterocycles, which include -CN, -NH2, and C 1~6 Substituting as needed with one or more substituents independently selected from alkyl; Y is -O-; R 2 The heterocyclic portion of the -L-heterocyclic ring is selected from -L-heterocyclic rings and -LN(CH3)2, and the heterocyclic portion of the -L-heterocyclic ring is one or more R 6 Replaced as needed; Each L is independently selected from C1-C4 alkylenes, optionally substituted with one or more substituents independently selected from C1-C4 alkyl groups; optionally, two substituents on the same carbon atom of L combine to form a C3-C4 carbocyclic or 4-membered heterocyclic ring, the C3-C4 carbocyclic and 4-membered heterocyclic rings, respectively, optionally substituted with one or more substituents independently selected from halogens; Each R 6 These are independently selected from halogens, C1-C3 hydroxyalkyls, C1-C3 alkyls, oxo, C1-C3 haloalkyls, =CH2, (C1-C3 alkoxy)C1-C3 alkyl-, and -CH2-O-heterocycles. The complex ring of the -CH2-O- complex ring is C 1~6 Alkyl, C 1~6 Haloalkyl, C 1~6 Alkyl-OR 20 , and -OR 20 Replaced as needed with one or more substituents selected from; Each R 10 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C2~6 Alkynnyls are independently selected from C3-C6 carbon rings and 5-7 membered heterocycles, and the C3-C6 carbon rings and 5-7 membered heterocycles are halogens, -OH, -CN, -NO2, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2, C 1~5 Alkyl, -C 1~5 Haloalkyl, -OC 1~5 Each substituent is optionally substituted with one or more substituents independently selected from alkyl and oxo; Each R 11 is halogen, -B(OR 20 )2, -OR 20 , -SR 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkynnyls are independently selected from C3-C6 carbon rings and 5-9 membered heterocycles, where C3-C6 carbon rings and 5-9 membered heterocycles are halogens, -OH, -CN, -NO2, -N(R) 21 )2, -SR 21 ,-C(O)N(R 21 )2, C 1~5 Alkyl, -C 1~5 Haloalkyl, -OC 1~5 Alkyl, -S(O)2(R 21 ), -P(O)(OR 21)2, -OP(O)(OR 21 )2, -P(O)(R 21 )2, and each as needed, substituted with one or more substituents independently selected from the oxo; Each R 11A is halogen, -B(OR 20 )2, -OR 20 , -SR 20 ,-C(O)N(R 20 )2, -N(R 20 )C(O)R 20 , -N(R 20 )C(O)OR 20 , -N(R 20 )2, -C(O)R 20 , -C(O)OR 20 -OC(O)R 20 ,-OC(O)N(R 20 )2, -NO2, =O, =NO(R 20 ), -CN, -NHCN, C 1~6 alkyl-N(R 20 )2, C 1~6 Aminoalkyl, C 1~6 Alkoxy, C 1~6 Hydroxyalkyl, C 1~6 Cyanoalkyl, C 1~6 Haloalkyl, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is selected independently of alkinil.

[0245] In some embodiments, formula (I) or formula (IC * Regarding compounds or salts of ), [ka] teeth, [ka] It is represented by. In some cases, [ka] teeth, [ka] It is represented by. In some cases, [ka] teeth, [ka] It is represented by. In some cases, [ka] teeth, [ka] It is represented by. In some cases, [ka] teeth, [ka] It is represented by. In some cases, [ka] teeth, [ka] It is represented by. In some cases, [ka] teeth, [ka] It is represented by. In some cases, [ka] teeth, [ka] It is represented by. In some cases, [ka] teeth, [ka] It is represented by YR. In some cases, 2 teeth, [ka] Selected from. In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, YR 2 teeth, [ka] In some cases, [ka] teeth, [ka] [ka] [ka] Selected from. In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] In some cases, [ka] teeth, [ka] That is the case.

[0246] In some embodiments, formulas (I), (IA), (IB), (IC), and (IC) are used. *For compounds or salts of formulas (ID), (IE), (IF), (IG), (IH), (II), and (IJ), the compound is not a Michael acceptor.

[0247] In some embodiments, formulas (I), (IA), (IB), (IC), and (IC) are used. * For compounds or salts of formulas (ID), (IE), (IF), (IG), (IH), (II), and (IJ), the compounds or salts do not contain electrophilic substituents.

[0248] In some embodiments, formulas (I), (IA), (IB), (IC), and (IC) are used. * For compounds or salts of formulas (ID), (IE), (IF), (IG), (IH), (II), and (IJ), the compound or salt contains an electrophilic moiety.

[0249] In some embodiments, formulas (I), (IA), (IB), (IC), and (IC) are used. * For compounds or salts of formulas (ID), (IE), (IF), (IG), (IH), (II), and (IJ), the compounds or salts do not contain an electrophilic moiety.

[0250] In some embodiments, formulas (I), (IA), (IB), (IC), and (IC) are used. * For compounds or salts of formulas (ID), (IE), (IF), (IG), (IH), (II), and (IJ), the compounds or salts do not form covalent bonds with KRAS G12D and / or any other G12 mutants.

[0251] In some embodiments, formulas (I), (IA), (IB), (IC), and (IC) are used. *For compounds or salts of formulas (ID), (IE), (IF), (IG), (IH), (II), and (IJ), the compound or salt forms a covalent bond with any of KRAS G12D and / or other G12 mutants.

[0252] In some embodiments, formulas (I), (IA), (IB), (IC), and (IC) are used. * For compounds or salts of formulas (ID), (IE), (IF), (IG), (IH), (II), and (IJ), the compound or salt is not a covalent modifier of KRAS G12D and / or other G12 mutants.

[0253] In some embodiments, formulas (I), (IA), (IB), (IC), and (IC) are used. * For compounds or salts of formulas (ID), (IE), (IF), (IG), (IH), (II), and (IJ), the compound or salt is a covalent modifier of KRAS G12D and / or other G12 mutants.

[0254] In some embodiments, formulas (I), (IA), (IB), (IC), and (IC) are used. * For compounds or salts of formulas (ID), (IE), (IF), (IG), (IH), (II), and (IJ), the compound or salt can react with cysteine.

[0255] In some embodiments, formulas (I), (IA), (IB), (IC), and (IC) are used. * For compounds or salts of formulas (ID), (IE), (IF), (IG), (IH), (II), and (IJ), the compound or salt is not a covalent inhibitor of KRAS G12D and / or other G12 mutants.

[0256] Salts of the compounds described herein, in particular pharmaceutically acceptable salts, are included in this disclosure. Compounds of the present invention having sufficient acidic functional groups, sufficient basic functional groups, or both functional groups, can react with many inorganic bases, as well as either inorganic or organic acids, to form salts. Alternatively, intrinsically charged compounds, such as compounds having quaternary nitrogen, can form salts with suitable counterions, such as bromine, chlorine, or fluorine, and halides such as bromine in particular.

[0257] Chemical entities having a carbon-carbon double bond or a carbon-nitrogen double bond may exist in Z or E form (or cis or trans form). Furthermore, some chemical entities may exist in various tautomerized forms. Unless otherwise specified, the compounds described herein are intended to include all Z, E, and tautomerized forms.

[0258] A "tautomer" refers to a molecule in which a proton shift from one atom of the molecule to another atom of the same molecule is possible. The compounds presented herein exist as tautomers in certain embodiments. In situations where tautomerization is possible, a chemical equilibrium of tautomers exists. The exact ratio of tautomers depends on several factors, including physical state, temperature, solvent, and pH. Some examples of tautomer equilibrium are: [ka] Includes.

[0259] The compounds disclosed herein, in some embodiments, are in different enriched isotopic forms, for example, 2 H, 3 H, 11 C, 13 C and / or 14It is used in a form in which the C content is concentrated. In a particular embodiment, the compound is deuterated at at least one position. Such a deuterated form can be prepared by the procedure described in U.S. Patents No. 5,846,514 and No. 6,334,997. As described in U.S. Patents No. 5,846,514 and No. 6,334,997, deuteration can improve metabolic stability and / or efficacy, and thus increase the duration of action of the drug.

[0260] Unless otherwise stated, the compounds described herein are intended to include compounds that differ only in the presence of one or more isotopically enriched atoms. For example, the substitution of hydrogen with deuterium or tritium, or 13 C or 14 Compounds having this structure, except for the substitution of carbon with concentrated carbon, are within the scope of this disclosure.

[0261] The compounds of this disclosure may optionally contain non-natural proportion atomic isotopes in one or more atoms constituting such compounds. For example, the compounds may contain isotopes, such as deuterium ( 2 H), tritium ( 3 H), Iodine-125( 125 I) or carbon-14 ( 14 It may also be marked with C), etc. 2 H, 11 C, 13 C, 14 C, 15 C, 12 N, 13 N, 15 N, 16 N, 16 O, 17 O, 14 F, 15 F, 16 F, 17 F, 18 F, 33 S, 34 S, 35 S, 36 S, 35 Cl, 37 Cl, 79 Br,81 Br, and 125 All isotopic substitutions by I are intended. All isotopic variations of the compounds of the present invention, whether radioactive or not, are included within the scope of the present invention.

[0262] In certain embodiments, the compounds disclosed herein are 1 Some or all of the H atoms 2 It is replaced by a hydrogen atom. Methods for the synthesis of deuterium-containing compounds are known in the art and include, merely as non-limiting examples, the following synthesis methods.

[0263] Deuterium-substituted compounds are synthesized using various methods, such as those described in Dean, Dennis C.; Editor. Recent Advances in the Synthesis and Applications of Radiolabeled Compounds for Drug Discovery and Development. [In: Curr., Pharm. Des., 2000; 6(10)] 2000, 110 pp; George W.; Varma, Rajender S. The Synthesis of Radiolabeled Compounds via Organometallic Intermediates, Tetrahedron, 1989, 45(21), 6601-21; and Evans, E. Anthony. Synthesis of radiolabeled compounds, J. Radioanal. Chem., 1981, 64(1-2), 9-32.

[0264] Deuterated starting materials are readily available and, when used in the synthesis methods described herein, provide for the synthesis of deuterium-containing compounds. Numerous deuterium-containing reagents and building blocks are commercially available from chemical suppliers such as Aldrich Chemical Co.

[0265] The compounds of the present invention include, for example, polymorphs, pseudopolymorphs, solvates, hydrates, non-solvated polymorphs (including anhydrous forms), conformational polymorphs, and amorphous forms of the compounds, as well as mixtures thereof, pharmaceutically acceptable salts, and crystalline and amorphous forms of active metabolites of these compounds having the same kind of activity.

[0266] The compounds described herein may, in some cases, exist in diastereomer, enantiomer, or other stereoisomeric forms. Where absolute stereochemistry is not specified, the compounds presented herein include all diastereomeric, enantiomeric, and epimeric forms, as well as suitable mixtures thereof. Separation of stereoisomers may be performed by chromatography, by forming diastereomers and separating them by recrystallization or chromatography, or any combination thereof (Jean Jacques, Andre Collet, Samuel H. Wilen, "Enantiomers, Racemates and Resolutions", John Wiley And Sons, Inc., 1981, incorporated herein by reference for this disclosure). Stereoiomers may also be obtained by stereoselective synthesis.

[0267] The methods and compositions described herein include the use of amorphous and crystalline forms (also known as polymorphs). The compounds described herein may also be in the form of pharmaceutically acceptable salts. Similarly, in some embodiments, active metabolites of these compounds having the same type of activity are included in the scope of this disclosure. In addition, the compounds described herein may exist in non-solvated forms and in solvated forms with pharmaceutically acceptable solvents such as water and ethanol. The solvated forms of the compounds presented herein are also considered to be disclosed herein.

[0268] In certain embodiments, the compound or a salt of the compound may be a prodrug, for example, the hydroxyl in the compound may exist as an ester or carbonate, or the carboxylic acid present in the compound may exist as an ester. The term “prodrug” is intended to encompass compounds that, under physiological conditions, are converted into the pharmaceutical agents of the present disclosure. One method for preparing a prodrug is to include one or more selected moieties that are hydrolyzed under physiological conditions to yield a desired molecule. In other embodiments, the prodrug is converted by the enzymatic activity of a host animal, such as specific target cells in the host animal. For example, esters or carbonates (e.g., esters or carbonates of alcohols or carboxylic acids, and esters of phosphonic acids) are preferred prodrugs of the present disclosure.

[0269] The prodrug forms of the compounds described herein, in which the prodrug is metabolized in vivo to produce the compounds described herein, are included within the scope of the claims. In some cases, a portion of the compounds described herein may be a prodrug for another derivative or active compound.

[0270] Prodrugs are often useful because, in some situations, they may be easier to administer than their parent drugs. For example, they may be bioavailable by oral administration, whereas the parent drug is not. Prodrugs may help enhance the cellular permeability of a compound compared to its parent drug. Prodrugs may also have improved solubility in pharmaceutical compositions than their parent drugs. Prodrugs may be designed as reversible drug derivatives for use as modifiers to enhance drug delivery to site-specific tissues or to increase drug resistance within cells.

[0271] In some embodiments, the design of the prodrug increases the lipid solubility of the pharmaceutical agent. In some embodiments, the design of the prodrug increases the effective water solubility. For example, such disclosures are incorporated herein by reference: Fedorak et al., Am. J. Physiol., 269:G210-218 (1995); McLoed et al., Gastroenterol, 106:405-413 (1994); Hochhaus et al., Biomed. Chrom., 6:283-286 (1992); J. Larsen and H. Bundgaard, Int. J. Pharmaceutics, 37, 87 (1987); J. Larsen et al., Int. J. Pharmaceutics, 47, 103 (1988); Sinkula et al., J. Pharm. Sci., 64:181-210 (1975); T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems, Vol. 14 of the ACS Symposium. See Series; and Edward B. Roche, Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987. According to another embodiment, the present disclosure provides a method for producing the compounds defined above. The compounds may be synthesized using conventional techniques. Advantageously, these compounds can be conveniently synthesized from readily available starting materials.

[0272] The synthetic chemical transformations and methodologies useful for the synthesis of the compounds described herein are publicly known in the art, including, for example, those described in R. Larock, Comprehensive Organic Transformations (1989); TW Greene and PGM Wuts, Protective Groups in Organic Synthesis, 2d. Ed. (1991); L. Fieser and M. Fieser, Fieser and Fieser's Reagents for Organic Synthesis (1994); and L. Paquette, ed., Encyclopedia of Reagents for Organic Synthesis (1995). Pharmaceutical preparations

[0273] In a particular embodiment, the therapeutically effective amount is given by formulas (I), (IA), (IB), (IC), and (IC) * Compositions comprising any one of the compounds or salts of formula (ID), formula (IE), formula (IF), or formula (IG) (also referred to herein as "pharmaceutical agent") are provided herein.

[0274] Pharmaceutical compositions may be formulated using one or more physiologically acceptable carriers, including additives and adjuvants, that facilitate the processing of the pharmaceutical agent into a preparation for pharmaceutical use. The suitable formulation depends on the chosen route of administration. A summary of pharmaceutical compositions can be found, for example, in Remington: The Science and Practice of Pharmacy, Nineteenth Ed (Easton, Pa., Mack Publishing Company, 1995); Hoover, John E., Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pennsylvania 1975; Liberman, HA and Lachman, L., Eds., Pharmaceutical Dosage Forms, Marcel Decker, New York, NY, 1980; and Pharmaceutical Dosage Forms and Drug Delivery Systems, Seventh Ed. (Lippincott Williams & Wilkins, 1999).

[0275] The compositions and methods of this disclosure may be used to treat individuals that require them. In certain embodiments, the individuals are mammals, e.g., humans or non-human mammals. When administered to animals, e.g., humans, the compositions or pharmaceutical agents are preferably administered as a pharmaceutical composition comprising, for example, the pharmaceutical agent and a pharmaceutically acceptable carrier or additive. Pharmaceutically acceptable carriers are well known in the art and include, for example, aqueous solutions, e.g., water or physiological buffer saline, or other solvents or vehicles, e.g., glycols, glycerols, oils such as olive oil, or organic esters for injection. In preferred embodiments, if such a pharmaceutical composition is for human administration, particularly for invasive routes of administration, e.g., injection or implantation, to avoid transport or diffusion through the epithelial barrier, the aqueous solution is pyrogen-free or substantially pyrogen-free. Additives may be selected, for example, to cause delayed release of the drug or to selectively target one or more cells, tissues or organs. The pharmaceutical composition may be in the form of dosage units such as tablets, capsules, granules, freeze-dried preparations for reconstitution, powders, liquids, syrups, suppositories, or injections. The composition may also be present in transdermal delivery systems, such as skin patches. The composition may also be present in liquids suitable for topical administration, such as eye drops.

[0276] Pharmacoherent additives may include, for example, physiologically acceptable agents that act to stabilize, increase solubility of, or increase the absorption of compounds such as pharmaceuticals. Examples of such physiologically acceptable agents include carbohydrates such as glucose, sucrose, or dextran; antioxidants such as ascorbic acid or glutathione; chelating agents; low molecular weight proteins; or other stabilizers or excipients. The selection of pharmaceutically acceptable additives, including physiologically acceptable agents, depends, for example, on the route of administration of the composition. The preparation or pharmaceutical composition may be a self-emulsifying drug delivery system or a self-microemulsifying drug delivery system. The pharmaceutical composition (preparation) may also be a liposome or other polymer matrix, which, for example, can incorporate the compounds of the present invention. For example, liposomes containing phospholipids or other lipids are non-toxic, physiologically acceptable, and metabolizable carriers that are relatively easy to prepare and administer.

[0277] Pharmaceutical compositions (preparations) can be administered to a target by any of many routes of administration, including, for example, oral, by immersion in aqueous or non-aqueous solutions or suspensions, tablets, capsules including sprinkle capsules and gelatin capsules, boluses, powders, granules, pastes for application to the tongue; absorption through the oral mucosa, e.g., sublingual; anal, rectal, or vaginal, e.g., pessaries, creams, or foams; parenteral, e.g., intramuscular, intravenous, subcutaneous, or intrathecal as a sterile solution or suspension; nasal; intraperitoneal; subcutaneous; transdermal, e.g., patches applied to the sk...

Claims

1. Compound of formula (I): 【Chemical Formula 923】 or a pharmaceutically acceptable salt thereof [in the formula, R １００ teeth, 【Chemical 924】 Selected from; R １Ａ is selected from C １～６ alkyl, C ３ -C １２ carbocyclic ring, and 4- to 12-membered heterocyclic ring, each of which is optionally substituted with one or more R １１ and, optionally, two R １Ａ on the same atom of R １１ together form a C ３ -C ６ carbocyclic ring or 3- to 8-membered heterocyclic ring, and the C ３ -C ６ carbocyclic ring and 3- to 8-membered heterocyclic ring are each optionally substituted with one or more R １１Ａ ; R １Ｂ is hydrogen, C １～６ Alkyl, C ３ ~C ６ Selected from a carbon ring or a 4- to 6-membered heterocycle, the C １～６ Alkyl, C ３ ~C ６ Carbon rings and 4- to 6-membered heterocycles have one or more R １０ Are they replaced as needed? Or R １Ａ and R １Ｂ Together with the atoms they bond to, R １ Forms R １ This is a 5- to 15-membered heterocycle, and the 5- to 15-membered heterocycle is a halogen, -B (OR ２０ ) ２ , -N(R ２０ ) ２ , -OR ２０ , -SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -C(=NR ２０ )N(R ２０ ) ２ , -C １～６ Alkyl (=NR ２０ OR ２０ ), -C(O)NR ２０ OR ２０ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = N (R ２０ ), = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl-SO ２ R ２０ , C １～６ Alkoxyalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C １２ The C is optionally substituted with one or more substituents independently selected from a carbon ring and a 5- to 12-membered heterocycle. ３ ~C １２ The carbon ring and the 5- to 12-membered heterocycle have one or more R １＊ They are independently replaced as needed; Each R １＊ is independently selected from halogen, -B(OR ２０ ), -OR ２ , -SR ２０ , -S(O) ２０ (R ２ ), -S(O) ２０ N(R ２ ), ２０ -S(O)N(R ２ ), -S(O)R ２０ )(=NR ２ [[ID= / / ]]), -NR ２０ S(O) ２０ R ２０ ), -C(O)N(R ２ ), -C(O)NR ２０ OR ２０ ), -N(R ２ )(C(O)R ２０ ), -N(R ２０ )(C(O)N(R ２０ ), -N(R ２０ )(C(O)OR ２０ ), -N(R ２０ [[ID= / / ]]), -C(O)R ２ ), -C(O)OR ２０ ), -OC(O)R ２０ ), -OC(O)N(R ２０ ), -NO ２ ), =O, =N(R ２０ ), =NO(R ２０ ), -CN, -NHCN, C ２０ alkyl-N(R ２０ ), C ２ aminoalkyl, C ２ alkoxy, C ２０ hydroxyalkyl, C ２０ cyanoalkyl, C １～６ haloalkyl, C ２０ alkyl, C ２ alkenyl, C< / / >alkynyl, and C １～６ to C １～６ carbocyclic rings, independently selected;​​​​​​​​​​​​​​ R １Ｃ is hydrogen, C １～６ Alkyl, C ３ ~C １２ Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R １２ Replaced as needed, R １Ｃ Two R on the same atom １２ Together, C ３ ~C ６ Forming a carbon ring or a 3- to 8-membered heterocycle, the C ３ ~C ６ The carbon ring and the 3- to 8-membered heterocycle have one or more R １２Ａ Each is replaced as needed; R １Ｄ is hydrogen, C １～６ Alkyl, C ３ ~C １２ Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R １３ Replaced as needed, R １Ｄ Two R on the same atom １３ Together, C ３ ~C ６ Forming a carbon ring or a 3- to 8-membered heterocycle, the C ３ ~C ６ The carbon ring and the 3- to 8-membered heterocycle have one or more R １３Ａ Each is replaced as needed; Y is -O-; R ２ is a heteroalgebra, a -L-heteroalgebra, and a -L-N(R) ２０ ) ２ , -L-OR ２０ -L-aryl, -L-heteroaryl, -L-cycloalkyl, -L-NHC(=NH)NH ２ , -LC(O)N(R ２０ ) ２ , -L-C １ ~C ６ Haloalkyl, -L-NR ２０ C(O)-aryl, -L-COOH, -L-NR ２０ S(O) ２ (R ２０ ), -L-S(O) ２ N(R) ２０ ) ２ , -L-N(R ２０ )C(O)(OR ２０ ), -L-OC(O)N(R ２０ ) ２ , and -L-C(=O)OC １ ~C ６ Selected from alkyl groups, the heterocycle, the heterocyclic portion of the -L-heterocycle, and the cycloalkyl portion of the -L-cycloalkyl group are one or more R ６ Each is replaced as needed, -L-NR ２０ The aryl portion of C(O)-aryl, the aryl portion of -L-aryl, and the heteroaryl portion of -L-heteroaryl are one or more R ７ Each is replaced as needed; Each L represents halogen, hydroxyl, and C. １～６ Alkoxy, C １ ~C ４ Hydroxyalkyl, C １ ~C ４ Alkyl, C ３ ~C ６ A carbon ring and a carbon ring optionally substituted with one or more substituents independently selected from 3- to 8-membered heterocycles. １ ~C ４ Selected independently from alkylene, the C ３ ~C ６ Carbon rings and 3- to 8-membered heterocycles are halogens, -OH, and -NO. ２ , =O, =S, -CN,C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Each is optionally substituted with one or more substituents independently selected from the haloalkyl; optionally, two substituents on the same carbon atom of L are combined to form C ３ ~C ６ Forming a carbon ring or a 3- to 8-membered heterocycle, the C ３ ~C ６ Carbon rings and 3- to 8-membered heterocycles are halogens, -OH, and -NO. ２ , =O, =S, -CN,C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, and C １～６ Each substituent is optionally substituted with one or more substituents independently selected from the haloalkyl group; Each R ４ Halogen, -NO ２ , -NH ２ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , =O, =S, -CN,C １～６ Alkyl, C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Cyanoalkyl, C １～６ Hydroxyalkyl, and C １～６ Selected independently from haloalkyl groups; n is selected from 0, 1, 2, 3, and 4; m is selected from 1 and 2; Each R ５ is hydrogen and C １ ~C ６ Selected independently of alkyl; Each R ６ is halogen, hydroxy, C １ ~C ３ Hydroxyalkyl, C １ ~C ３ Alkyl, oxo, C １ ~C ３ Haloalkyl, C １ ~C ３ Alkoxy, cyano, =CH ２ , = NO-C １ ~C ３ Alkyl, C １ ~C ３ Aminoalkyl, -N(R) ５ ) S(O) ２ (R ５ ), -Q-phenyl, -Q-phenylSO ２ F,-NHC(O)phenyl,-NHC(O)phenylSO ２ F, C １ ~C ３ Alkyl-substituted pyrazolyl, tert-butyldimethylsilyloxy CH ２ -, -N(R ５ ) ２ , (C １ ~C ３ Alkoxy) C １ ~C ３ Alkyl-, (C １ ~C ３ Alkyl) C (= O), oxo, (C １ ~C ３ Haloalkyl)C(=O)-, -SO ２ F, (C １ ~C ３ Alkoxy) C １ ~C ３ Alkoxy, -CH ２ OC(O)NCF ３ (R ５ ), -CH ２ O-C １ ~C ６ Alkyl, -CH ２ OC(O)N(R) ５ ) ２ ien-CH ２ NHC(O)OC １ ~C ６ Alkyl, -CH ２ NHC(O)N(R) ５ ) ２ ien-CH ２ NHC(O)C １ ~C ６ Alkyl, -CH ２ (Pyrazolyl), -CH ２ NHSO ２ C １ ~C ６ Alkyl, -CH ２ OC(O) heteroalgebra, -OC(O)N(R ５ ) ２ , -OC(O)NH(C １ ~C ３ Alkyl)O(C １ ~C ３ Alkyl), -OC(O)NH(C １ ~C ３ Alkyl)O(C １ ~C ３ Alkyl)phenyl (C １ ~C ３ Alkyl)N(CH ３ ) ２ , -OC(O)NH(C １ ~C ３ Alkyl)O(C １ ~C ３ Alkyl)phenyl, -OC(O) heterocycle, -O-C １ ~C ３ Alkyl, -O-C １ ~C ６ Haloalkyl, -C １ ~C ３ Alkyl-O-C １ ~C ６ Haloalkyl, C １～６ Alkyl-N(R) ２０ ) ２ , -SF ５ , -C １ ~C ３ Alkyl-N ３ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ ,-(CH ２ ) ０～１ S-heterogenetic ring, -(CH ２ ) ０～１ -O- Heterogeneous ring, -(CH ２ ) ０～１ -O-phenyl and -CH ２ Selected independently from complex algebras, -NHC(O)phenyl and -OC(O)NH(C １ ~C ３ (Alkyl) (C １ ~C ３ The phenyl in alkyl(phenyl)phenyl is optionally substituted with one or more substituents selected from -C(O)H and OH. -O-C １ ~C ３ The alkyl group of the alkyl group is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups; -CH ２ O-C １ ~C ６ The alkyl in alkyl refers to halogens and C ３ ~C ６ Substituted as needed with one or more substituents selected from the carbocyclic ring; -CH ２ The complex ring of a complex ring is substituted with oxos as needed; - (CH ２ ) ０～１ -O-phenyl's phenyl is C １～６ Alkyl, C １～６ Haloalkyl, SF ５ , C １～６ Alkyl-OR ２０ , -OR ２０ Substituting as necessary with one or more substituents selected from; - (CH ２ ) ０～１ -O- Heterocyclic rings and -(CH ２ ) ０～１ The complex algebra of -S- is C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkyl-OR ２０ , and -OR ２０ Each substituent is optionally replaced by one or more substituents selected from; Each Q is selected from combinations and O; Each R ７ is halogen, hydroxyl, HC(=O)-, C １ ~C ４ Alkyl, C １ ~C ４ Alkoxy, C １ ~C ４ Haloalkyl, C １ ~C ４ Hydroxyalkyl and -N(R ５ ) ２ Selected independently of; R ８ The 5- to 12-membered heterocycle is selected from halogens, -CN, and -NO. ２ , = O, -N(R ２０ ) ２ , -B(OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -C(O)R ２０ , C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -C(O)NR ２０ -OR ２０ , C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Alkoxyalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C １２ Optionally substituted with one or more substituents independently selected from carbocyclic and 5- to 12-membered heterocycles; R ９ These are hydrogen, halogen, -CN, and -NO ２ , -N(R ２０ ) ２ , -OR ２０ ,-SR ２０ , C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxyalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl and C ３ ~C ６ Selected from the carbon ring, the C ３ ~C ６ The carbon ring contains one or more halogens, -CN, and -NO. ２ , -N(R ２０ ) ２ , -OR ２０ ,-SR ２０ , C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxyalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl is substituted as needed; or R ８ and R ９ These, together with the atoms they bond to, form B, which is a 7-15 membered heterocycle and C ７ ~C １５ Selected from carbon rings, the aforementioned 7-15 membered heterocycles and C ７ ~C １５ The carbon ring consists of halogens, -CN, and -NO. ２ , = O, -N(R ２０ ) ２ , -B(OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -C(O)NR ２０ OR ２０ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Alkoxyalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C １２ Each is optionally substituted with one or more substituents independently selected from the carbocyclic and 5- to 12-membered heterocycles; Each R １０ is halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C １２ A carbon ring and a 5- to 12-membered heterocycle are independently selected, and the C ３ ~C １２ Carbon rings and 5- to 12-membered heterocycles include halogens, -OH, -CN, and -NO. ２ , -NH ２ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , C １～１０ Alkyl, -C １～１０ Haloalkyl, -O-C １～１０ Each substituent is optionally substituted with one or more substituents independently selected from alkyl and oxo; Each R １１ , R １２ , and R １３ is halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NR ２０ (C=NH)N(R) ２０ ) ２ , -NO ２ , = O, = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C １２ A carbon ring and a 5- to 12-membered heterocycle are independently selected, and the C ３ ~C １２ Carbon rings and 5- to 12-membered heterocycles include halogens, -OH, -CN, and -NO. ２ , -N(R ２１ ) ２ ,-SR ２１ , -C(O)N(R ２１ ) ２ , C １～１０ Alkyl, -C １～１０ Haloalkyl, -O-C １～１０ Alkyl, -S(O) ２ (R ２１ ), -P(O)(OR ２１ ) ２ , -OP(O)(OR ２１ ) ２ , -P(O)(R ２１ ) ２ , and each may be optionally substituted with one or more substituents independently selected from the oxo; Each R １１Ａ , R １２Ａ , and R １３Ａ is halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Selected independently of Alkinnil; Each R ２０ hydrogen; and each of them is a halogen, -OH, -CN, -NO ２ , -NH ２ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , C １～１０ Alkyl, C １～１０ Haloalkyl, -O-C １～１０ Alkyl, oxo, C ３～１２ A carbon ring and a carbon ring optionally substituted with one or more substituents independently selected from 3- to 12-membered heterocycles. １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１２ Independently selected from carbon rings and 3- to 12-membered heterocycles; Each R ２１ hydrogen; and each of them is a halogen, -OH, -CN, -NO ２ , -NH ２ , -N(C １～６ Alkyl) ２ , C １～１０ Alkyl, -C １～１０ Haloalkyl, -O-C １～１０ Alkyl, oxo, C ３～１２ A carbon ring and a carbon ring optionally substituted with one or more substituents independently selected from 3- to 12-membered heterocycles. １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１２ [Independently selected from carbon rings and 3- to 12-membered heterocycles.]

2. R １００ but, 【Chemical 925】 A compound or salt according to claim 1, selected from the above.

3. R １００ but, 【Chemical Formula 926】 The compound or salt according to claim 1.

4. Equation (I) is, 【Chemical Formula 927】 The compound or salt according to any one of claims 1 to 3, or represented by a pharmaceutically acceptable salt thereof.

5. Equation (I) is, 【Chemical Formula 928】 The compound or salt according to any one of claims 1 to 3, or represented by a pharmaceutically acceptable salt thereof.

6. Equation (I) is, 【Chemical 929】 The compound or salt according to any one of claims 1 to 3, or represented by a pharmaceutically acceptable salt thereof.

7. Each R ９ However, hydrogen, halogen, -CN, -N(R) ２０ ) ２ , -OR ２０ , C １～６ Aminoalkyl, C １～６ Alkoxyalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl and C ３ ~C ６ Selected from cycloalkyl, the C ３ ~C ６ Cycloalkyl groups contain one or more halogens, -CN, and -NO ２ , -N(R ２０ ) ２ , -OR ２０ ,-SR ２０ , C １～６ Aminoalkyl, C １～６ Alkoxyalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl and C １～６ The compounds or salts according to claims 1 to 6, which are optionally substituted with alkyl groups.

8. Each R ９ However, hydrogen, -CN, C １～６ Aminoalkyl, C １～６ Alkoxyalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl and C ３ ~C ６ Selected from cycloalkyl, the C ３ ~C ６ Cycloalkyl groups contain one or more halogens, -CN, and -NO ２ , -N(R ２０ ) ２ , -OR ２０ ,-SR ２０ , C １～６ Aminoalkyl, C １～６ Alkoxyalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl and C １～６ The compound or salt according to claim 7, which is optionally substituted with an alkyl group.

9. Each R ９ However, hydrogen, halogen, C １～６ Alkyl and C ３ ~C ６ A compound or salt according to claim 8, selected from cycloalkyl groups.

10. Each R ９ The compound or salt according to claim 9, selected from hydrogen, fluorine, methyl, and cyclopropyl.

11. R ８ The compound or salt according to any one of claims 1 to 10, selected as necessary from substituted 5- to 6-membered heteroaryl compounds.

12. R ８ The compound or salt according to any one of claims 1 to 11, selected from substituted five-membered heteroaryl compounds as needed.

13. R ８ The compound or salt according to any one of claims 1 to 12, wherein the heteroaryl has at least one sulfur atom.

14. R ８ The aforementioned heteroaryl is 【Chemical 930】 The compound or salt according to any one of claims 1 to 10, wherein this is substituted as necessary.

15. R ８ The one or more substituents as needed are halogens, C １～６ Alkyl, C １～６ Haloalkyl, -N(R) ２０ ) ２ A compound or salt according to any one of claims 1 to 14, independently selected from , and -CN.

16. R ８ but, 【Chemical 931】 A compound or salt according to any one of claims 1 to 15, selected from the above.

17. R ８ The compound or salt according to any one of claims 1 to 10, selected as necessary from substituted 6- to 9-membered heteroaryl compounds.

18. R ８ but, 【Chemical 932】 A compound or salt according to claim 17, selected from, each of which is substituted as necessary.

19. R ８ The one or more substituents as needed are halogens, C １～６ Alkyl, C １～６ Haloalkyl, -N(R) ２０ ) ２ A compound or salt according to claim 17 or 18, independently selected from , and -CN.

20. R ８ The one or more substituents as needed are halogens, C ２～６ Alkyl, C １～６ Haloalkyl, -N(R) ２０ ) ２ A compound or salt according to any one of claims 17 to 19, independently selected from , and -CN.

21. R ８ The one or more substituents as needed are halogens, C １～６ Haloalkyl, -N(R) ２０ ) ２ A compound or salt according to claim 20, independently selected from , and -CN.

22. R ８ but, 【Chemical 933】 A compound or salt according to any one of claims 17 to 21, selected from the above.

23. R ８ The compound or salt according to any one of claims 1 to 10, selected from substituted nine-membered heteroaryl compounds as needed.

24. R ８ The compound or salt according to claim 23, wherein the heteroaryl has at least one sulfur atom.

25. R ８ The compound or salt according to claim 23 or 24, wherein the heteroaryl is bicyclic.

26. R ８ but, 【Chemical 934】 The compound or salt according to any one of claims 23 to 25, wherein this is substituted as necessary.

27. R ８ The one or more substituents as needed are halogens, C １～６ Alkyl, C １～６ Haloalkyl, -N(R) ２０ ) ２ A compound or salt according to claim 26, independently selected from , and -CN.

28. R ８ but, 【Chemical 935】 The compound or salt according to any one of claims 24 to 27.

29. R ８ The compound or salt according to any one of claims 1 to 10, selected from substituted 5 to 12-membered unsaturated heterocycles as needed.

30. R ８ The compound or salt according to claim 29, selected from a substituted nine-membered unsaturated heterocycle as needed.

31. R ８ The compound or salt according to any one of claims 29 to 30, wherein the heterocycle is a bicyclic heterocycle.

32. R ８ The compound or salt according to any one of claims 29 to 31, wherein the heterocycle has at least one sulfur atom.

33. R ８ The aforementioned complex ring of is 【Chemical 936】 The compound or salt according to any one of claims 29 to 32, wherein this is substituted as necessary.

34. R ８ The one or more substituents as needed are halogens, -N(R ２０ ) ２ A compound or salt according to claim 33, independently selected from and -CN.

35. R ８ but, 【Chemical 937】 The compound or salt according to claim 34.

36. B is an 8- to 15-membered condensed heteroring which is substituted as needed, and C which is substituted as needed. ８ ~C １５ A compound or salt according to any one of claims 1 to 35, selected from condensed carbocyclic compounds.

37. The compound or salt according to claim 1 or 36, wherein B is an 8- to 15-membered condensed heterocycle which is optionally substituted, and B contains at least one heteroatom selected from nitrogen, sulfur, and selenium.

38. B is replaced by C as needed. ８ ~C １５ The compound or salt according to claim 1 or 36, which is a condensed carbon ring.

39. Regarding B, the 8-15 member condensed heterocycles substituted as necessary and C substituted as necessary ８ ~C １５ The compound or salt according to any one of claims 36 to 38, wherein each condensed carbon ring is independently bicyclic or tricyclic.

40. The compound or salt according to any one of claims 36 to 39, wherein the heterocycle or carbon ring of B is bicyclic.

41. The compound or salt according to any one of claims 36 to 39, wherein the heterocycle or carbon ring of B is a tricyclic compound.

42. Regarding B, the 8-15 member condensed heterocycles substituted as necessary and C substituted as necessary ８ ~C １５ The condensed carbon ring, 【Chemical Formula 938】 A compound or salt according to any one of claims 36 to 41, each of which is optionally substituted with one or more substituents.

43. Regarding B, the 8-15 member condensed heterocycles substituted as necessary and C substituted as necessary ８ ~C １５ The condensed carbon ring, 【Chemical Formula 939】 The compound or salt according to claim 42, selected from, each of which is optionally substituted with one or more substituents.

44. Regarding B, the one or more optional substituents of the heterocycle and carbon ring are oxo, -NH ２ , halogen, and C １ ~C ３ A compound or salt according to any one of claims 36 to 43, independently selected from alkyl groups.

45. Regarding B, the 8-15 member condensed heterocycles substituted as necessary and C substituted as necessary ８ ~C １５ The condensed carbon ring, 【Chemical 940】 A compound or salt according to any one of claims 36 to 44, selected from the above.

46. R ８ and R ９ The compound or salt according to any one of claims 1 to 3 or 6, wherein they combine with the atoms to which they bond to form B.

47. The compound or salt according to claim 1, 6, or 46, wherein B contains at least one heteroatom selected from nitrogen, oxygen, sulfur, and selenium.

48. B is an 8- to 15-membered heterocycle which is substituted as needed, and C which is substituted as needed. ８ ~C １５ A compound or salt according to claim 46 or 47, selected from a carbocyclic ring.

49. B is an 8- to 15-membered condensed heteroring which is substituted as needed, and C which is substituted as needed. ８ ~C １５ A compound or salt according to claim 46 or 47, selected from condensed carbocyclic compounds.

50. The compound or salt according to claim 46 or 47, wherein B is an 8- to 15-membered condensed heterocycle which is optionally substituted.

51. B is an unsaturated C which is substituted as needed. ８ ~C １５ The compound or salt according to claim 46 or 47, which is a condensed carbon ring.

52. The compound or salt according to any one of claims 46 to 51, wherein, with respect to B, the heterocycle and the carbon ring are each independently bicyclic or tricyclic.

53. The compound or salt according to claim 52, wherein, with respect to B, the heterocycle and the carbon ring are each independently bicyclic.

54. The compound or salt according to claim 52, wherein, with respect to B, the heterocyclic ring and the carbon ring are each independently tricyclic.

55. B, 【Chemical 941】 A compound or salt according to any one of claims 46 to 54, selected from, each of which is optionally substituted with one or more substituents.

56. B, 【Chemical 942】 The compound or salt according to claim 55, selected from, each of which is optionally substituted with one or more substituents.

57. B, 【Chemical 943】 The compound or salt according to claim 56, selected from, each of which is optionally substituted with one or more substituents.

58. Regarding B, the one or more substituents as needed are oxo, -NH ２ , halogen, C １ ~C ３ A compound or salt according to any one of claims 46 to 57, independently selected from alkyl groups.

59. B, 【Chemical 944】 A compound or salt according to claim 58, selected from the above.

60. Regarding B, the one or more of the necessary substituents on the heterocycle and carbon ring, in their respective appearances, are halogens, C １ ~C ３ Alkyl, -B (OR ２０ ) ２ , -OR ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) ２ ,=O, -CN, -NHCN,C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C ２～６ Alkenyl and C ２～６ A compound or salt according to any one of claims 46 to 57, independently selected from alkynyl.

61. Regarding B, the one or more optional substituents of the heterocycle and carbon ring, in their respective appearances, are halogen, oxo, and -NH. ２ , C １ ~C ３ Alkyl, -B(OH) ２ -OH, -O-C １ ~C ３ Haloalkyl, -C(O)NH ２ , -NH ２ , = O, -CN, C １～６ Alkoxy, C １～６ Hydroxyalkyl, and C ２～６ A compound or salt according to claim 59, independently selected from alkynyl.

62. B, 【Chemical 945】 【Chemical Formula 946】 A compound or salt according to claim 60 or 61, selected from the above.

63. The compound or salt according to claim 1 or any one of claims 46 to 54, wherein B is a 7- to 12-membered condensed heterocycle that is optionally substituted.

64. The compound or salt according to claim 1 or 63, wherein B is a 7- to 11-membered condensed heterocycle which is optionally substituted.

65. The compound or salt according to claim 63 or 64, wherein B is an 8- to 10-membered condensed heterocycle which is optionally substituted.

66. The compound or salt according to claim 65, wherein B is an 8-9 membered condensed heterocycle which is substituted as needed.

67. The compound or salt according to any one of claims 63 to 66, wherein the heterocycle is an unsaturated heterocycle.

68. The compound or salt according to any one of claims 63 to 67, wherein B has at least one sulfur atom.

69. The compound or salt according to any one of claims 63 to 68, wherein B has at least one sulfur atom and at least one nitrogen atom.

70. The compound or salt according to any one of claims 63 to 69, wherein B has at least one sulfur atom and at least one oxygen atom.

71. The compound or salt according to any one of claims 63 to 70, wherein B has two sulfur atoms.

72. B, 【Chemical Formula 947】 A compound or salt according to any one of claims 63 to 71, selected from, each of which is substituted as necessary.

73. B, 【Chemical 948】 A compound or salt according to claim 72, selected from, each of which is substituted as necessary.

74. B, 【Chemical 949】 A compound or salt according to claim 73, selected from, each of which is substituted as necessary.

75. The one or more of the optional substituents of B, in their respective appearances, are halogen, oxo, and -NH ２ , C １ ~C ３ Alkyl, -B(OH) ２ -OH, -O-C １ ~C ３ Haloalkyl, -C(O)NH ２ , -NH ２ , = O, -CN, C １～６ Alkoxy, C １～６ Hydroxyalkyl, and C ２～６ A compound or salt according to any one of claims 63 to 74, independently selected from alkynyl.

76. The one or more of the optional substituents of B, in their respective appearances, are halogens, C １ ~C ３ Alkyl, -NH ２ A compound or salt according to claim 75, independently selected from , and -CN.

77. B, 【Chemical 950】 A compound or salt according to any one of claims 63 to 76, selected from the above.

78. B is a 7- to 12-membered condensed heterocycle which is substituted as needed, and C which is substituted as needed. ９～１０ A compound or salt according to any one of claims 46 to 54, selected from condensed carbocyclic compounds.

79. The compound or salt according to claim 78, wherein the heterocycle of B has at least one sulfur atom.

80. The compound or salt according to claim 78 or 79, wherein the heterocycle of B has one or two sulfur atoms.

81. The compound or salt according to claim 80, wherein the heterocycle of B has at least one nitrogen atom.

82. B, 【Chemical 951】 A compound or salt according to any one of claims 77 to 80, selected from, each of which is substituted as necessary.

83. each of said one or more optional substituents of B, in each occurrence, is halogen, C １ ~C ３ alkyl, -B(OR ２０ ), -OR ２ , -C(O)N(R ２０ ), -N(R ２０ ), =O, -CN, -NHCN, C ２ aminoalkyl, C ２０ alkoxy, C ２ hydroxyalkyl, C １～６ cyanoalkyl, C １～６ haloalkyl, C １～６ alkenyl, and C １～６ alkynyl, independently selected from, a compound or salt according to any one of claims 78 to 82.​​​​​​

84. The one or more of the optional substituents of B, in their respective appearances, are halogens, C １ ~C ３ alkyl, -OH, -NH ２ A compound or salt according to claim 83, independently selected from ,=O, and -CN.

85. B, 【Chemical 952】 A compound or salt according to claim 84, selected from the above.

86. The compound or salt according to any one of claims 78 to 81, wherein B is selected from optionally substituted 8- to 10-membered condensed heterocycles having at least one sulfur atom.

87. B, 【Chemical 953】 A compound or salt according to claim 86, selected from, each of which is substituted as necessary.

88. The one or more of the optional substituents of B, in their respective appearances, are halogens, C １ ~C ３ Alkyl, -OR ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) ２ , =O, -CN, -NHCN, C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C ２～６ Alkenyl and C ２～６ A compound or salt according to claim 86 or 87, independently selected from alkynyl.

89. The one or more of the optional substituents of B, in their respective appearances, are halogens, C １ ~C ３ Alkyl, -NH ２ A compound or salt according to claim 88, independently selected from , and -CN.

90. A compound or salt according to any one of claims 86 to 89, wherein B is substituted.

91. B has at least one -NH ２ A compound or salt according to any one of claims 86 to 90, which is substituted with

92. B, 【Chemical 954】 A compound or salt according to any one of claims 86 to 91, selected from the above.

93. B has at least one -NH ２ and the compound or salt according to any one of claims 86 to 91, which is substituted with at least one -CN.

94. B, 【Chemical 955】 A compound or salt according to claim 92, selected from the above.

95. B, 【Chemical 956】 The compound or salt according to claim 1 or 6.

96. B, 【Chemical 957】 The compound or salt according to claim 1 or 6.

97. A compound or salt according to any one of claims 1 to 96, wherein n is selected from 0 and 1.

98. A compound or salt according to any one of claims 1 to 97, wherein n is 1.

99. Each R ４ However, halogen, -NO ２ , -NH ２ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , = O, -CN, C １～６ Alkyl, C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Cyanoalkyl, C １～６ Hydroxyalkyl, and C １～６ A compound or salt according to any one of claims 1 to 98, independently selected from haloalkyls.

100. Each R ４ However, a compound or salt according to claim 99, which is independently selected from =O.

101. A compound or salt according to any one of claims 1 to 96, wherein n is 0.

102. A compound or salt according to any one of claims 1 to 101, wherein Y is -O-.

103. L is C １ ~C ４ A compound or salt according to any one of claims 1 to 102, selected from alkylenes.

104. L is an unsubstituted C １ ~C ４ A compound or salt according to claim 103, selected from alkylenes.

105. Each L is replaced with C as needed. １ ~C ４ Independently selected from alkylenes; if necessary, two substituents on the same carbon atom of L, together, C ３ ~C ６ Forming a carbon ring or a 3- to 8-membered heterocycle, the C ３ ~C ６ Carbon rings and 3- to 8-membered heterocycles are halogens, -OH, and -NO. ２ , =O, =S, -CN,C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ The compound or salt according to any one of claims 1 to 102, each optionally substituted with one or more substituents selected from haloalkyl groups.

106. The optional substituent of L is selected from C １ to C ４ hydroxyalkyl, C １ to C ４ alkyl, C ３ to C ６ selected from carbocycles; optionally, two substituents on the same carbon atom of L together form a C ３ to C ６ carbocycle or a 3- to 8-membered heterocycle, and the C ３ to C ６ carbocycles and 3- to 8-membered heterocycles are optionally substituted with one or more substituents selected from halogen and C １～６ haloalkyl, the compound or salt according to claim 105.

107. L, 【Chemical Formula 958】 A compound or salt according to any one of claims 105 to 106, selected from the above.

108. L, 【Chemical Formula 959】 A compound or salt according to claim 107, selected from the above.

109. Each L is replaced by C １ ~C ４ Independently selected from alkylene, two substituents on the same carbon atom of L, together form C ３ ~C ６ The compound or salt according to claim 105 or 106, which forms a carbon ring or a 3- to 5-membered heterocycle.

110. Each L is replaced by C ２～３ Independently selected from alkylene, two substituents on the same carbon atom of L, together form C ３ Forming a carbon ring or a four-membered heterocycle, the C ３ The compound or salt according to claim 109, wherein the carbon ring is optionally substituted with one or more substituents selected from halogens.

111. Each L is, 【Chemical Formula 960】 A compound or salt according to claim 109 or 110, independently selected from the above.

112. Each L is, 【Chemical 961】 A compound or salt according to claim 111, independently selected from the above.

113. Each L is, 【Chemical 962】 A compound or salt according to claim 112, independently selected from the above.

114. Each L is halogen and C １ ~C ４ C as needed, substituted with one or more substituents independently selected from alkyl １ ~C ４ A compound or salt according to claim 109 or 110, independently selected from alkylenes.

115. L, 【Chemical 963】 A compound or salt according to claim 114, selected from the above.

116. Each L is an unsubstituted C １ ~C ４ A compound or salt according to claim 114, independently selected from alkylenes.

117. L, 【Chemical 964】 A compound or salt according to claim 116, selected from the above.

118. L, 【Chemical 965】 A compound or salt according to claim 117, selected from the above.

119. R ２ However, heterocycles, -L-heterocycles, -L-aryls, -L-heteroaryls, and -L-N(R) ２０ ) ２ Selected from, the heterocyclic portion of the heterocyclic ring, the -L-heterocyclic ring, is one or more R ６ Each is substituted as necessary, and the aryl of the -L-aryl and the heteroaryl of the -L-heteroaryl are one or more R ７ A compound or salt according to any one of claims 1 to 118, wherein each is substituted as necessary.

120. R ２ However, it is a -L-complex ring, and R ２ The compound or salt according to claim 119, wherein the heterocyclic portion is a heterocyclic ring that is optionally substituted.

121. R ２ However, 1 or more R ６ The compound or salt according to claim 119 or 120, wherein the -L-heterocycle is substituted as necessary, and the heterocycle portion of the -L-heterocycle has at least one heteroatom selected from nitrogen, oxygen, silicon, and sulfur.

122. Y-R ２ but, 【Chemical Formula 966】 Selected from, the complex ring portion is one or more R ６ A compound or salt according to any one of claims 1 to 121, which is substituted as necessary.

123. R ２ The aforementioned heterocyclic portion is halogen, hydroxy, -CN, C ｌ ~C ３ Hydroxyalkyl, C １ ~C ３ Alkyl, C １ ~C ３ Haloalkyl, C １ ~C ３ Alkoxy, and C １ ~C ３ The compound or salt according to any one of claims 119 to 122, which is a heterocycle optionally substituted with one or more substituents selected from aminoalkyl groups.

124. R ２ The aforementioned complex ring portion of C １ ~C ３ The compound or salt according to claim 123, which is a heterocycle optionally substituted with one or more substituents selected from alkyl and halogen.

125. Y-R ２ but, 【Chemical 967】 A compound or salt according to any one of claims 1 to 124, selected from the above.

126. R ２ R ６ However, with each appearance, halogen, hydroxyl, C １ ~C ３ Hydroxyalkyl, C １ ~C ３ Alkyl, C １ ~C ３ Haloalkyl, C １ ~C ３ Alkoxy, cyano, and C １ ~C ３ A compound or salt according to any one of claims 119 to 122, independently selected from aminoalkyls.

127. R ２ R ６ However, with each appearance, C １ ~C ３ A compound or salt according to claim 124, independently selected from alkyl and halogen.

128. Y-R ２ but, 【Chemical 968】 A compound or salt according to claim 127, selected from the above.

129. Y-R ２ but, 【Chemical Formula 969】 【Chemical 970】 Selected from, the complex ring portion is one or more R ６ A compound or salt according to any one of claims 1 to 121, which is substituted as necessary.

130. Y-R ２ but, 【Chemical 971】 A compound or salt according to claim 129, selected from the above.

131. Y-R ２ but, 【Chemical 972】 A compound or salt according to any one of claims 1 to 121, wherein the heterocycle is selected from and, if necessary, substituted.

132. The aforementioned heterocycle is a halogen, hydroxyl, C １ ~C ３ Alkyl, -N(R ５ ) S(O) ２ (R ５ ), -OC(O)N(R ５ ) ２ ❖ = CH ２ , oxo, = NO-C １ ~C ３ Alkyl, -CH ２ OC(O) heteroalgebra, -CH ２ Heterogeneous ring, -CH ２ OC(O)N(R) ５ ) ２ , and -O-C １ ~C ３ Optionally substituted with one or more substituents selected from alkyl groups, -O-C １ ~C ３ The compound or salt according to claim 131, wherein the alkyl group of the alkyl is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups.

133. Y-R ２ but, 【Chemical 973】 【Chemical 974】 A compound or salt according to any one of claims 1 to 6 or 131 to 132, selected from among them.

134. Y-R ２ but, 【Chemical 975】 Selected from, the heterocyclic portion is substituted as necessary, and one or more substituents as necessary are halogen, hydroxyl, C １ ~C ３ Alkyl, -N(R ５ ) S(O) ２ (R ５ ), -OC(O)N(R ５ ) ２ ❖ = CH ２ , oxo, = NO-C １ ~C ３ Alkyl, -CH ２ OC(O) heteroalgebra, -CH ２ Heterogeneous ring, -CH ２ OC(O)N(R) ５ ) ２ ,-(CH ２ ) ０～１ -O-heterogenetic rings, and -O-C １ ~C ３ Selected from alkyl groups, -O-C １ ~C ３ The alkyl group of the alkyl group is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups, -(CH ２ ) ０～１ -O- The complex ring of the complex ring is C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkyl-OR ２０ , and -OR ２０ A compound or salt according to any one of claims 1 to 121, which is optionally substituted with one or more substituents selected from the following.

135. The aforementioned one or more substituents as needed 【Chemistry 976】 A compound or salt according to claim 134, selected from the above.

136. Y-R ２ but, 【Chemical Formula 977】 【Chemical Formula 978】 A compound or salt according to claim 134 or 135, selected from the above.

137. R ２ However, it is a -L-heteroaryl, and the heteroaryl portion is one or more R ７ The compound or salt according to claim 119, which is substituted as necessary.

138. Each R ７ However, halogens, and C １ ~C ４ A compound or salt according to claim 137, independently selected from haloalkyl groups.

139. Y-R ２ but, 【Chemical 979】 A compound or salt according to claim 138, selected from the above.

140. R ２ However, 1 or more R ７ The compound or salt according to claim 119, wherein the -L-aryl is substituted as necessary.

141. Y-R ２ but, 【Chemical Formula 980】 Selected from, the phenyl portion is one or more R ７ The compound or salt according to claim 140, which is substituted as necessary.

142. Y-R ２ but, 【Chemical 981】 A compound or salt according to claim 141, selected from the above.

143. R ２ However, 1 or more R ７ The compound or salt according to claim 119, wherein the -L-heteroaryl is substituted as necessary.

144. Y-R ２ but, 【Chemical Engineering 982】 Selected from, the heteroaryl portion is one or more R ７ The compound or salt according to claim 143, which is substituted as necessary.

145. Y-R ２ but, 【Chemistry 983】 A compound or salt according to claim 143 or 144, selected from the above.

146. R ２ However, -L-N(R ２０ ) ２ The compound or salt according to claim 119.

147. Y-R ２ but, 【Chemical Formula 984】 A compound or salt according to claim 146, selected from the above.

148. R ２ However, 1 or more R ６ The compound or salt according to claim 119, wherein the heterocycle is substituted as necessary.

149. Y-R ２ but, [Chemical Engineering 985] The compound or salt according to claim 148.

150. Y-R ２ but, 【Chemical 986】 The compound or salt according to claim 1 to 6 or 126.

151. R ２ However, the heterocycle, the -L-heterocycle (where the heterocycle portion of the heterocycle and the -L-heterocycle is one or more R ６ (These are substituted as needed); -L-aryl and -L-heteroaryl (where the aryl of the -L-aryl and the heteroaryl of the -L-heteroaryl are one or more R ７ (These are substituted as needed); and -L-N(R ２０ ) ２ A compound or salt according to any one of claims 1 to 119, selected from the above.

152. R ２ The aforementioned complex ring of is 【Chemical 987】 Selected from, R ２ The aforementioned complex ring is one or more R ６ Replaced as needed; R ２ The aryl and heteroaryl in the above are 【Chemical 988】 Selected from, the aryl and heteroaryl are one or more R ７ ; and 【Chemical 989】 The compound or salt according to claim 151, each of which is substituted as necessary.

153. R ２ The aforementioned complex ring of is 【Chemical Formula 990】 Selected from, the complex ring is one or more R ６ Replaced as needed; R ２ The aryl and heteroaryl in the above are 【Chem.991】 Selected from, the aryl and heteroaryl are one or more R ７ ; and 【Chemical Formula 992】 The compound or salt according to claim 152, wherein each is substituted as necessary.

154. Each R ６ However, halogens, hydroxy, C １ ~C ３ Alkyl, C １ ~C ３ Haloalkyl, -N(R) ５ ) S(O) ２ (R ５ ), -OC(O)N(R ５ ) ２ ❖ = CH ２ , oxo, = NO-C １ ~C ３ Alkyl, -CH ２ OC(O) heteroalgebra, -CH ２ Heterogeneous ring, -CH ２ OC(O)N(R) ５ ) ２ , and -O-C １ ~C ３ Selected independently of alkyl, -O-C １ ~C ３ The alkyl group of the alkyl group is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups; each R ７ However, C １ ~C ３ Alkyl, halogen and C １ ~C ３ A compound or salt according to any one of claims 151 to 153, selected from haloalkyls.

155. R ２ The aforementioned complex ring, R ２ The aforementioned aryl and heteroaryl, and R ２ -N(R ２０ ) ２ but, 【Chemical 993】 【Chemical Formula 994】 A compound or salt according to any one of claims 151 to 154, selected from the above.

156. Y-R ２ but, 【Chemistry 995】 (Here, the heterocyclic portion of the heterocyclic ring and the -L-heterocyclic ring is one or more R ６ (These are replaced as needed); [996] (Here, the aryl in the -L-aryl and the heteroaryl in the -L-heteroaryl are one or more R ７ (These are replaced as needed); and 【Chemical Formula 997】 A compound or salt according to any one of claims 1 to 118, selected from the above.

157. Y-R ２ but, 【Chemical Formula 998】 【Chemical Formula 999】 A compound or salt according to any one of claims 1 to 118, selected from the above.

158. Y-R ２ but, 【Chemical 1000】 【Chemistry 1001】 【Chemical 1002】 A compound or salt according to any one of claims 1 to 118, selected from the above.

159. Y-R ２ but, 【Chemical 1003】 A compound or salt according to any one of claims 1 to 118, selected from the above.

160. Y is -O-, R ２ However, it is selected from L-5 member heteroaryls, where L is substituted as needed. １ ~C ４ Selected from alkylenes, the heteroaryl is one or more R ７ And they are replaced as needed, and each R ７ However, preferably, halogen, C １ ~C ４ Alkyl and C １ ~C ４ A compound or salt according to any one of claims 1 to 118, selected from haloalkyls.

161. Y-R ２ but, 【Chemical 1004】 A compound or salt according to any one of claims 160, selected from the above.

162. Y-R ２ but, 【Chemistry 1005】 (Here, the heterocyclic portion of the heterocyclic ring and the -L-heterocyclic ring is one or more R ６ (These are replaced as needed); 【Chemistry 1006】 (Here, the aryl in the -L-aryl and the heteroaryl in the -L-heteroaryl are one or more R ７ (These are replaced as needed); and 【Chemistry 1007】 A compound or salt according to any one of claims 1 to 118, selected from the above.

163. Each R ６ However, halogens, hydroxy, C １ ~C ３ Alkyl, C １ ~C ３ Haloalkyl, oxo, C １ ~C ３ Alkoxy, C １ ~C ３ Hydroxyalkyl, (C １ ~C ３ Alkoxy) C １ ~C ３ Alkyl-, =CH ２ , -OC(O)N(R ５ ) ２ , = NO-C １ ~C ３ Alkyl, -N(R ５ ) S(O) ２ (R ５ ), -CH ２ OC(O)N(R) ５ ) ２ ien-CH ２ OC(O) heteroalgebra, -(CH ２ ) ０～１ S-heterogenetic ring, -(CH ２ ) ０～１ -O-heterogenetic rings, and -O-C １ ~C ３ Selected independently of alkyl, -O-C １ ~C ３ The alkyl group of the alkyl group is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups, -(CH ２ ) ０～１ -O- Heterocyclic rings and -(CH ２ ) ０～１ -S- The complex ring of the complex ring is C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkyl-OR ２０ , and -OR ２０ The compound or salt according to claims 1 to 118 or 162, each optionally substituted with one or more substituents selected from the above.

164. Each R ６ but, 【Chemistry 1008】 , oxo, 【Chemistry 1009】 A compound or salt according to claim 163, independently selected from the above.

165. Y-R ２ but, 【Chemical 1010】 【Chemistry 1011】 【Chemistry 1012】 A compound or salt according to any one of claims 1 to 118 or 163 to 164, selected from among them.

166. R １Ｂ The compound or salt according to any one of claims 1 to 165, wherein the compound is hydrogen.

167. R １Ｂ However, C was replaced as needed. １～６ A compound or salt according to any one of claims 1 to 165, selected from alkyl groups.

168. R １Ｂ The compound or salt according to any one of claims 1 to 165, wherein the compound is methyl.

169. R １Ｂ However, C was replaced as needed. ３ ~C ６ A compound or salt according to any one of claims 1 to 165, selected from a carbocyclic ring.

170. R １Ａ However, C was replaced as needed. １～６ A compound or salt according to any one of claims 1 to 169, selected from alkyl groups.

171. R １１ However, -N(R ２０ ) ２ The compound or salt according to claim 170.

172. R １Ａ but, 【Chemical 1013】 A compound or salt according to claim 171, selected from the above.

173. R １Ａ However, C ４ ~C ６ It is a carbon ring, and the C ４ ~C ６ A carbon ring contains one or more R １１ A compound or salt according to any one of claims 1 to 172, which optionally contains the compound or salt described in the claim.

174. Each R １１ However, -N(R ２０ ) ２ Selected from, each R ２０ However, hydrogen and, if necessary, substituted C １～６ A compound or salt according to claim 173, selected from alkyl groups.

175. R １Ａ but, 【Chemical 1014】 A compound or salt according to claim 174, selected from the above.

176. R １Ａ However, one or more R are selected from 4- to 12-membered heterocycles, and the 4- to 12-membered heterocycles are R １１ A compound or salt according to any one of claims 1 to 175, which optionally contains the compound or salt described in the claim.

177. R １Ａ but, 【Chemical 1015】 Selected from, each of these is one or more R １１ And they are replaced as needed, and each R １１ However, -OH, C １～６ Aminoalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, -C(O)R ２０ , C ３ ~C １２ A carbon ring and a 5- to 12-membered heterocycle are independently selected, and the C ３ ~C １２ Carbon rings and 5- to 12-membered heterocycles are halogens, -OH, -CN, and -NO. ２ , -NH ２ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , C １～１０ Alkyl, -C １～１０ Haloalkyl, -O-C １～１０ The compound or salt according to any one of claims 1 to 169 or 176, each optionally substituted with one or more substituents independently selected from alkyl and oxo groups.

178. Each R １１ However, halogen, -OH, -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)N(R ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl and C １～６ A compound or salt according to claim 176 or 177, selected from alkyl groups.

179. R １Ａ but, 【Chemistry 1016】 A compound or salt according to claim 178, selected from the above.

180. R １Ａ However, C was replaced as needed. １～６ Selected from alkyl groups, and R as needed. １Ａ Two R on the same atom １１ However, together, C is replaced as needed. ３ ~C ６ A compound or salt according to any one of claims 1 to 169, which forms a carbon ring.

181. R １１ However, it is -CN, and R １Ａ Two R on the same atom １１ However, together, it becomes a non-substituted C ３ A compound or salt according to claim 180 that forms a carbon ring.

182. R １Ａ but, 【Chemical 1017】 A compound or salt according to claim 181, selected from the above.

183. R １Ａ but, 【Chemical 1018】 A compound or salt according to claim 182, selected from the above.

184. R １００ but, 【Chemical 1019】 A compound or salt according to any one of claims 1 to 3 or 7 to 165, selected from the above.

185. R １Ｂ However, hydrogen, and C as needed, are substituted. １～６ Alkyl and optionally substituted C ３ ~C ６ A compound or salt according to any one of claims 1 to 183, selected from a carbocyclic ring.

186. R １Ｂ However, hydrogen, C １～６ Alkyl, C １～６ Cyanoalkyl, C １～６ Hydroxyalkyl, and C ３ ~C ６ A compound or salt according to any one of claims 1 to 185, selected from a carbocyclic ring.

187. R １Ｂ However, hydrogen, methyl, ethyl, C ２ A compound or salt according to any one of claims 1 to 186, selected from hydroxyalkyl and cyclopropyl.

188. R １Ｂ The compound or salt according to any one of claims 1 to 187, wherein the compound is hydrogen.

189. R １Ｂ However, C was replaced as needed. １～６ A compound or salt according to any one of claims 1 to 188, selected from alkyl groups.

190. R １Ｂ a compound or salt according to any one of claims 1 to 189, selected from methyl and ethyl.

191. R １Ｂ The compound or salt according to any one of claims 1 to 190, wherein the compound is methyl.

192. R １Ｂ However, C was replaced as needed. ３ ~C ６ A compound or salt according to any one of claims 1 to 190, selected from a carbocyclic ring.

193. R １Ｂ but, 【Chemical 1020】 The compound or salt according to claim 192.

194. R １Ｂ However, hydrogen, C １～６ Alkyl, C ３ Selected from a carbon ring or a 4- to 5-membered heterocycle, the C １～６ Alkyl, C ３ A carbon ring and a 4- to 5-membered heterocycle are present in one or more R １０ Each is replaced as needed, and each R １０ However, halogen, -OR ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) ２ , -C(O)OR ２０ , = O, -CN, C ２～６ Alkenil, C １～６ Haloalkyl, C ３ ~C ６ A compound or salt according to claims 1 to 165, independently selected from a carbocyclic ring and a four-membered heterocyclic ring.

195. R １Ｂ but, 【Chemistry 1021】 A compound or salt according to claim 193, selected from the above.

196. R １Ａ However, C １～３ Alkyl, C ３ Selected from carbon rings and 5- to 6-membered heterocycles, each of which contains one or more R １１ Replaced as needed, R １Ａ Two R on the same atom １１ But together, C ３ A compound or salt according to any one of claims 1 to 195, which forms a carbon ring.

197. R １１ However, halogen, -OR ２０ , -N(R ２０ ) ２ , -C(O)N(R ２０ ) ２ , -CN, =O, -NH(C=NH)NH ２ , C ２～６ Alkenil, C ３ ~C ６ A carbon ring and a 5-6 membered heterocycle are selected, and the 5-6 membered heterocycle and C ３ ~C ６ The carbon ring is halogen, -SR ２１ , -P(O)(R ２１ ) ２ , -OH, -CN, -N(R ２１ ) ２ , -C(O)N(R ２１ ) ２ , C １～１０ Alkyl and -C １～１０ Each of the substituents is optionally substituted with one or more substituents independently selected from the haloalkyl group; optionally, R １Ａ Two R on the same atom １１ But together, C ３ A compound or salt according to any one of claims 1 to 196, which forms a carbon ring.

198. Each R ２１ However, hydrogen; and C １～６ Selected independently of alkyl, the C １～６ Alkyl, halogen, oxo, C ３～６ The compound or salt according to any one of claims 1 to 197, optionally substituted with one or more substituents independently selected from a carbon ring and a 3- to 6-membered heterocycle.

199. R １Ａ but, 【Chemical 1022】 【Chemical 1023】 【Chemical 1024】 A compound or salt according to any one of claims 1 to 198, selected from the above.

200. R １００ or 【Chemistry 1025】 but, 【Chemical 1026】 【Chemical 1027】 【Chemical 1028】 A compound or salt according to any one of claims 1 to 169 or 185 to 199, selected from among them.

201. R １００ or 【Chemistry 1029】 but, 【Chemistry 1030】 【Chemistry 1031】 【Chemistry 1032】 【Chemistry 1033】 A compound or salt according to any one of claims 1 to 169 or 185 to 200, selected from among them.

202. R １Ｂ However, C １～６ Selected from alkyl and 4- to 5-membered heterocycles, the C １～６ Alkyl and 4-5 membered heterocycles, one or more R １０ Each is replaced as needed, and each R １０ However, halogen, -OR ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) ２ , -C(O)OR ２０ , = O, -CN, C ２～６ Alkenil, C １～６ Haloalkyl, C ３ ~C ６ A compound or salt according to any one of claims 1 to 183, independently selected from a carbocyclic ring and a four-membered heterocyclic ring.

203. R １Ｂ but, 【Chemistry 1034】 A compound or salt according to claim 202, selected from the above.

204. R １００ or 【Chemistry 1035】 but, 【Chemistry 1036】 Preferably, 【Chemistry 1037】 The compound or salt according to claims 1 to 165, or 202 to 203.

205. R １００ or 【Chemical 1038】 but, 【Chemistry 1039】 A compound or salt according to claims 1 to 165 or 202 to 204, selected from among them.

206. R １Ａ However, C was replaced as needed. １～６ A compound or salt according to any one of claims 1 to 169 or 185 to 195, selected from alkyl groups.

207. R １Ａ However, C was replaced as needed. １～３ Selected from alkyl groups, and R as needed. １Ａ Two R on the same atom １１ But together, C ３ The compound or salt according to claim 206, which forms a carbon ring.

208. R １Ａ However, C was replaced as needed. １～２ A compound or salt according to claim 207, selected from alkyl groups.

209. R １Ａ but, 【Chemistry 1040】 A compound or salt according to any one of claims 206 to 208, selected from the above.

210. R １Ａ but, 【Chemistry 1041】 A compound or salt according to any one of claims 206 to 209, selected from the above.

211. R １Ａ but, 【Chemistry 1042】 A compound or salt according to any one of claims 206 to 210, selected from the above.

212. R １１ The compound or salt according to any one of claims 206 to 211, selected from substituted 5 to 12-membered heterocycles as needed.

213. R １１ The compound or salt according to any one of claims 206 to 212, selected as necessary from substituted 5 to 8-membered heterocycles.

214. R １１ The compound or salt according to any one of claims 206 to 196, selected from substituted 5- to 6-membered heterocycles as needed.

215. R １１ The compound or salt according to any one of claims 206 to 213, selected as necessary from substituted 5- to 6-membered heteroaryl compounds.

216. R １１ but, 【Chemistry 1043】 A compound or salt according to any one of claims 206 to 214, selected from, each of which is substituted as necessary.

217. R １１ but, 【Chemistry 1044】 A compound or salt according to any one of claims 206 to 216, selected from, each of which is substituted as necessary.

218. R １１ but, 【Chemistry 1045】 A compound or salt according to any one of claims 206 to 217, selected from, each of which is substituted as necessary.

219. The one or more substituents as needed may be halogen, -OH, -CN, -N(R) ２１ ) ２ , C １～１０ Alkyl and -C １～１０ A compound or salt according to any one of claims 206 to 218, independently selected from haloalkyls.

220. Each R ２１ However, hydrogen; and C １～６ Selected independently of alkyl, the C １～６ Alkyl, halogen, oxo, C ３～６ The compound or salt according to any one of claims 206 to 219, which is optionally substituted with one or more substituents independently selected from a carbon ring and a 3- to 6-membered heterocycle.

221. R １１ The one or more substituents as needed are halogens, C １～６ Haloalkyl, -NH ２ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , 【Chemistry 1046】 , and C １～１０ A compound or salt according to any one of claims 206 to 220, selected from alkyl groups.

222. R １１ The one or more substituents as needed are -NH ２ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , and C １～１０ A compound or salt according to any one of claims 206 to 221, selected from alkyl groups.

223. R １１ The one or more substituents as needed are -NH ２ , and C １～１０ A compound or salt according to any one of claims 206 to 222, selected from alkyl groups.

224. R １１ The one or more substituents as needed are -NH ２ A compound or salt according to any one of claims 206 to 223, selected from the above.

225. R １１ but, 【Chemistry 1047】 A compound or salt according to any one of claims 206 to 224, selected from the above.

226. R １Ａ but, 【Chemical 1048】 A compound or salt according to any one of claims 206 to 225, selected from the above.

227. R １Ａ but, 【Chemistry 1049】 A compound or salt according to any one of claims 206 to 226, selected from the above.

228. R １Ａ but, 【Chemistry 1050】 The compound or salt according to any one of claims 1 to 165 or 206 to 214.

229. R １００ or 【Chemistry 1051】 but, 【Chemistry 1052】 【Chemistry 1053】 A compound or salt according to any one of claims 1 to 165 or 185 to 195, selected from the above.

230. R １００ or 【Chemistry 1054】 but, 【Chemistry 1055】 【Chemistry 1056】 A compound or salt according to any one of claims 1 to 165 or 185 to 195, selected from the above.

231. R １００ or 【Chemistry 1057】 but, 【Chemical 1058】 A compound or salt according to any one of claims 1 to 165 or 185 to 195, selected from the above.

232. R １００ or 【Chemistry 1059】 but, 【Chemistry 1060】 A compound or salt according to claim 231, selected from the above.

233. R １００ or 【Chemistry 1061】 but, 【Chemistry 1062】 A compound or salt according to claim 232, selected from the above.

234. R １１ but, 【Chemistry 1063】 A compound or salt according to any one of claims 206 to 215, selected from, each of which is substituted as necessary.

235. R １１ but, 【Chemistry 1064】 A compound or salt according to any one of claims 206-215 or 234, selected from, each of which is substituted as necessary.

236. The one or more substituents as needed may be halogen, oxo, -OH, -OCH ３ , -CN, -N(R ２１ ) ２ , -C(O)N(R ２１ ) ２ , -P(O)(R ２１ ) ２ , -SCH ３ , C １～１０ Alkyl and -C １～１０ A compound or salt according to any one of claims 206-215 or 234-235, independently selected from haloalkyls.

237. R １１ The one or more substituents as needed may be halogen, oxo, -OH, -OCH ３ , C １～６ Haloalkyl, -NH ２ , -SCH ３ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , 【Chemistry 1065】 , and C １～６ A compound or salt according to any one of claims 206-215 or 234-236, selected from alkyl groups.

238. R １１ but, 【Chemical 1066】 【Chemistry 1067】 A compound or salt according to any one of claims 206-215 or 234-237, selected from among them.

239. R １００ or 【Chemical 1068】 but, 【Chemistry 1069】 【Chemistry 1070】 【Chemistry 1071】 A compound or salt according to any one of claims 1 to 165 or 185 to 195, selected from the above.

240. R １００ or 【Chemistry 1072】 but, 【Chemistry 1073】 【Chemistry 1074】 【Chemistry 1075】 A compound or salt according to any one of claims 1 to 165 or 185 to 195, selected from the above.

241. R １Ａ and R １Ｂ However, together with the atoms they bond to, R １ Forms R １ The compound or salt according to any one of claims 1 to 165, selected from substituted 5 to 12-membered heterocycles as needed.

242. R １ However, it is selected from a 5- to 12-membered heterocycle, and the 5- to 12-membered heterocycle is a halogen, -OH, -N(R) ２０ ) ２ , -NO ２ , = O, -CN, C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, and C １～６ The compound or salt according to claim 241, optionally substituted with one or more substituents independently selected from the haloalkyl group.

243. R １ However, it is selected from a 5- to 12-membered heterocycle, and the 5- to 12-membered heterocycle is a halogen, -OH, -N(R) ２０ ) ２ , -NO ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, and C １～６ The compound or salt according to claim 242, optionally substituted with one or more substituents independently selected from the haloalkyl group.

244. Each R ２０ However, hydrogen and C １～３ A compound or salt according to claim 241 or 243, selected from alkyl groups.

245. Each R ２０ However, hydrogen and C １ A compound or salt according to any one of claims 241 or 244, selected from alkyl groups.

246. R １ The compound or salt according to any one of claims 241 or 244, wherein the 5- to 12-membered heterocycle is unsaturated.

247. R １ The compound or salt according to any one of claims 241 or 244, wherein the 5- to 12-membered heterocycle is saturated.

248. R １ The compound or salt according to claim 241 or 244, wherein the 5- to 12-membered heterocycle is crosslinked.

249. R １ The compound or salt according to any one of claims 241 or 244, wherein the 5- to 12-membered heterocycle is a spiroheterocycle.

250. R １ The compound or salt according to any one of claims 241 or 244, wherein the 5- to 12-membered heterocycle is a fused heterocycle.

251. R １ The compound or salt according to any one of claims 241 or 244, wherein the 5- to 12-membered heterocycle is non-aromatic.

252. R １ but, 【Chemistry 1076】 A compound or salt according to either claim 241 or 251, selected from, each of which is substituted as necessary.

253. The one or more substituents as needed may be halogen, -OH, -N(R) ２０ ) ２ , -NO ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, =O, -CN,C １～６ Hydroxyalkyl, and C １～６ A compound or salt according to claim 252, each independently selected from haloalkyl groups.

254. R １ but, 【Chemistry 1077】 Selected from, each of these is halogen, -OH, -N(R) ２０ ) ２ , -NO ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, =O, -CN,C １～６ Hydroxyalkyl, and C １～６ The compound or salt according to claim 252 or 253, optionally substituted with one or more substituents independently selected from the haloalkyl group.

255. R １ but, 【Chemistry 1078】 A compound or salt according to claim 254, selected from the above.

256. R １ The compound or salt according to any one of claims 241 to 251, wherein the compound is selected from a 6- to 8-membered heterocycle, which is substituted as necessary.

257. R １ The compound or salt according to claim 256, wherein the compound is selected from a 7-membered saturated heterocycle, an 8-membered bridged heterocycle, and a 6- to 7-membered unsaturated heterocycle, each of which is substituted as necessary.

258. R １ but, 【Chemistry 1079】 A compound or salt according to claim 257, selected from, each of which is substituted as necessary.

259. The one or more substituents as needed are -OH, -CN, oxo, C １～６ A compound or salt according to claim 258, independently selected from cyanoalkyls.

260. R １ but, 【Chemical 1080】 A compound or salt according to claim 258 or 259, selected from the above.

261. R １ The compound or salt according to any one of claims 241 to 251, selected from a substituted 6- to 7-membered heterocycle as needed.

262. The compound or salt according to claim 261, wherein the 6- to 7-membered heterocycle contains only one nitrogen atom, and the 6- to 7-membered heterocycle is substituted as necessary.

263. R １ The compound or salt according to claim 262, selected from an unsaturated six-membered heterocycle as needed.

264. R １ The compound or salt according to any one of claims 261 to 263, selected from an unsaturated seven-membered heterocycle that is substituted as needed.

265. R １ but, 【Chemistry 1081】 A compound or salt according to any one of claims 261 to 264, selected from, any of which is substituted as necessary.

266. R １ but, 【Chemistry 1082】 A compound or salt according to any one of claims 265, selected from, any of which is substituted as necessary.

267. R １ The one or more substituents as needed are halogens, -OR ２０ , -N(R ２０ ) ２ , = O, -CN, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Alkyl, -NHCN, and C ２～６ A compound or salt according to any one of claims 261 to 266, each independently selected from alkynyls.

268. Each is a halogen, -OH, and -NH. ２ , -NO ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Haloalkyl and C １～６ The compound or salt according to any one of claims 261 to 267, optionally substituted with one or more substituents independently selected from alkyl.

269. R １ The compound or salt according to any one of claims 261 to 268, wherein one or more of the optional substituents are independently selected from halogens.

270. R １ but, 【Chemistry 1083】 A compound or salt according to any one of claims 261 to 269, selected from the above.

271. R １ but, 【Chemistry 1084】 Selected from, each is halogen, -OH, -NH ２ , -NO ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Haloalkyl and C １～６ The compound or salt according to any one of claims 256 to 257, optionally substituted with one or more substituents independently selected from alkyl.

272. R １ but, 【Chemistry 1085】 Selected from, each is halogen, -OH, -NH ２ , -NO ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Haloalkyl and C １～６ The compound or salt according to claim 271, optionally substituted with one or more substituents independently selected from alkyl.

273. R １ but, 【Chemical 1086】 Selected from, each is halogen and C １～６ The compound or salt according to claim 272, optionally substituted with one or more substituents independently selected from a haloalkyl group.

274. R １ but, 【Chemical 1087】 A compound or salt according to claim 273, selected from the above.

275. R １ but, 【Chemical 1088】 Selected from, this is halogen, -OH, -NH ２ , -NO ２ , C １～６ Cyanoalkyl, C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Haloalkyl and C １～６ The compound or salt according to any one of claims 256, optionally substituted with one or more substituents independently selected from alkyl.

276. R １ but, 【Chemical 1089】 Selected from, this is halogen and C １～６ The compound or salt according to claim 275, optionally substituted with one or more substituents independently selected from cyanoalkyl.

277. R １ but, 【Chemistry 1090】 A compound or salt according to claim 276, selected from the above.

278. R １ but, 【Chemistry 1091】 【Chemistry 1092】 【Chemistry 1093】 【Chemistry 1094】 【Chemistry 1095】 【Chemistry 1096】 【Chemistry 1097】 A compound or salt according to any one of claims 1 to 165, selected from the above.

279. R １ The compound or salt according to claim 241, but selected from substituted 6- to 7-membered heterocycles as needed.

280. The compound or salt according to claim 279, wherein the 6- to 7-membered heterocycle contains only one nitrogen atom and, optionally, one or more additional heteroatoms selected from oxygen and sulfur.

281. The compound or salt according to claim 279 or 280, wherein, as necessary, one or more additional heteroatoms are selected from sulfur.

282. The compound or salt according to any one of claims 279 to 281, wherein the 6- to 7-membered heterocycle contains only one nitrogen atom and does not further contain any additional heteroatoms.

283. The compound or salt according to any one of claims 279 to 282, wherein the 6- to 7-membered heterocycle is a non-aromatic 6- to 7-membered heterocycle.

284. R １ The compound or salt according to any one of claims 279 to 283, wherein the 6- to 7-membered heterocycles are bonded to each formula via the single nitrogen atom.

285. R １ but, 【Chemical 1098】 A compound or salt according to any one of claims 279 to 283, selected from, each of which is substituted as necessary.

286. R １ The one or more substituents as needed are halogen, -OH, -CN, C １～６ Cyanoalkyl, -NHCN, C １～６ Alkyl, oxo, and C ２～６ A compound or salt according to any one of claims 279 to 285, each independently selected from alkynyl.

287. R １ The compound or salt according to any one of claims 241 to 251, selected from substituted 6 to 10-membered heterocycles as needed.

288. R １ but, 【Chemical 1099】 A compound or salt according to claim 287, selected from, each of which is substituted as necessary.

289. The one or more substituents as needed are halogen, =O, -OH, -C(O)N(R) ２０ ) ２ , C ２～６ Alkinyl, -NHCN, -CN, C １～６ Aminoalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl and C １～６ A compound or salt according to claim 288, independently selected from alkyl groups.

290. R １ but, 【Chemical 1100】 A compound or salt according to claim 288 or 289, selected from the above.

291. R １ The compound or salt according to claim 241, selected from 7 to 11-membered spiroheterocycles.

292. R １ The compound or salt according to claim 291, selected from a 10-membered spiroheterocycle.

293. The compound or salt according to claim 291 or 292, wherein the spiroheterocycle has at least three nitrogen atoms.

294. R １ but, 【Chemical Engineering 1101】 A compound or salt according to claim 291, selected from, each of which is substituted as necessary.

295. R １ but, 【Chemical Engineering 1102】 Selected from, each of these is halogen, -OH, -N(R) ２０ ) ２ , -NO ２ , =O, -CN, -NHCN, C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ The compound or salt according to claim 294, which is optionally substituted with one or more substituents independently selected from the alkynyl compound.

296. R １ but, 【Chemical 1103】 A compound or salt according to claim 295, selected from the above.

297. R １ but, 【Chemical 1104】 A compound or salt according to claim 296, selected from the above.

298. R １ The compound or salt according to claim 241, selected from substituted unsaturated 9- to 11-membered heterocycles as needed.

299. R １ The compound or salt according to claim 298, selected from an unsaturated 10-membered heterocycle as needed.

300. R １ but, 【Chemical 1105】 The compound or salt according to claim 298 or 299, wherein this is substituted as necessary.

301. R １ but, 【Chemical Engineering 1106】 And this is halogen, -OH, -C(O)N(R) ２０ ) ２ , -C(O)NHOR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -NO ２ , = O, -CN, C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl and C ２～６ The compound or salt according to claim 300, optionally substituted with one or more substituents selected from alkynyls.

302. R １ but, 【Chemical 1107】 Selected from, each of these is halogen, -OH, -N(R) ２０ ) ２ , = O, -CN, C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl and C ２～６ The compound or salt according to claim 301, further optionally substituted with one or more substituents selected from alkynyls.

303. R １ The one or more of the above-mentioned optional substituents are halogen, -OH, -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -C(O)N(R ２０ ) ２ , -C(O)NHOR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -NO ２ , = O, -CN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Alkoxyalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl and C ２～６ A compound or salt according to any one of claims 298 to 302, independently selected from alkynyl.

304. R １ but, 【Chemical 1108】 【Chemical 1109】 A compound or salt according to claim 302 or 303, selected from, each of which is substituted as necessary.

305. R １ but, 【Chemical 1110】 A compound or salt according to claim 304, selected from the above.

306. R １ The one or more substituents as needed are halogen, -OH, -N(R ２０ ) ２ , = O, -CN, C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, -C(O)N(R) ２０ ) ２ , C １～６ Alkyl and C ２～６ A compound or salt according to claim 300, independently selected from alkynyl.

307. R １ The one or more optional substituents of the above are halogens and -C(O)N(R ２０ ) ２ A compound or salt according to claim 306, independently selected from the above.

308. R １ but, 【Chemical 1111】 A compound or salt according to claim 307, selected from the above.

309. R １ but, 【Chemistry 1112】 The compound or salt according to claim 308.

310. R １ but, 【Chemical 1113】 The compound or salt according to claim 308.

311. R １ The one or more substituents as needed are halogens, C １～６ Alkyl, C １～６ Alkyl-N(R) ２０ ) ２ , -C(O)NR ２０ OR ２０ , -C(O)N(R ２０ ) ２ , and -C(O)R ２０ A compound or salt according to claim 300, independently selected from the above.

312. R １ The one or more substituents as needed are chlorine, 【Chemistry 1114】 A compound or salt according to claim 311, selected from the above.

313. R １ but, 【Chemical 1115】 A compound or salt according to claim 312, selected from the above.

314. R １ The one or more substituents as needed are halogens, -N(R ２０ ) ２ ,-CN,C １～６ Alkyl, C １～６ Cyanoalkyl, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Alkyl-SO ２ -C １～６ Alkyl, C ２～６ Alkenyl, -C(O)NR ２０ OR ２０ , -C(O)N(R ２０ ) ２ , -C(O)R ２０ , and independently selected from 5- to 10-membered heterocycles, wherein the 5- to 10-membered heterocycle is one or more R １＊ They are independently substituted as needed, and each R １＊ However, halogen, -OR ２０ , and C １～６ A compound or salt according to claim 300, independently selected from alkyl groups.

315. R １ The one or more substituents as needed are chlorine, -NH ２ ,-CN,C １ Alkyl, C ２ Alkenil, 【Chemical 1116】 【Chemical 1117】 A compound or salt according to claim 314, selected from the above.

316. R １ but, 【Chemical 1118】 【Chemical 1119】 【Chemistry 1120】 A compound or salt according to claim 315, selected from the above.

317. R １ The compound or salt according to any one of claims 241 to 251, selected as necessary from substituted 6 to 11-membered heterocycles (e.g., 6, 7, 8, 9, 10, and 11-membered heterocycles).

318. R １ The one or more substituents as needed are halogens, -OR ２０ , -C(O)N(R ２０ ) ２ , -C(O)R ２０ , -S(O) ２ R ２０ , = O, -C １～６ Alkyl (=NR ２０ OR ２０ ), = NO (R ２０ ), -CN, -NHCN, C １～６ Selected from alkyl and 5- to 12-membered heterocycles, the 5- to 12-membered heterocycle is one or more R １＊ They are independently replaced as needed; each R １＊ However, halogens, and C １～６ A compound or salt according to claim 317, independently selected from alkyl groups.

319. R １ but, 【Chemistry 1121】 【Chemistry 1122】 A compound or salt according to claim 317 or 318, selected from the above.

320. R １ but, 【Chemical 1123】 【Chemistry 1124】 A compound or salt according to claim 318 or 319, selected from the above.

321. R １ but, 【Chemical 1125】 【Chemical 1126】 A compound or salt according to any one of claims 317 or 318, selected from the above.

322. R １ but, 【Chemistry 1127】 A compound or salt according to any one of claims 241 to 251, selected from, each of which is substituted as necessary.

323. R １ The aforementioned one or more substituents as needed are -OH,=NO(R ２０ ), -NHCN, and C １～６ A compound or salt according to claim 322, selected from alkyl groups.

324. R １ However, hydrogen, 【Chemical 1128】 【Chemistry 1129】 A compound or salt according to claim 322 or 323, selected from the above.

325. R １ The compound or salt according to any one of claims 241 to 251, selected from substituted 7 to 10-membered heterocycles as needed.

326. R １ However, hydrogen, 【Chemistry 1130】 A compound or salt according to claim 325, selected from, each of which is substituted as necessary.

327. R １ The one or more substituents as needed are halogens, -NH ２ , -S(O) ２ (R ２０ ), -C(O)R ２０ , -C(O)N(R ２０ ) ２ , = O, = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl and 5-12 membered heterocycles are independently selected, and the 5-12 membered heterocycle is one or more R １＊ They are independently replaced as needed; each R １＊ However, halogens, and C １～６ A compound or salt according to claim 326, independently selected from alkyl groups.

328. R １ but, 【Chemistry 1131】 【Chemistry 1132】 A compound or salt according to any one of claims 325 to 327, selected from the above.

329. R １ The compound or salt according to claim 241, selected from substituted 8- to 10-membered heterocycles as needed.

330. The compound or salt according to claim 329, wherein the heterocycle is a bicyclic compound.

331. The compound or salt according to claim 329 or 330, wherein the heterocycle has at least two nitrogen atoms. 【Request Item 332】 【Chemistry 1133】 The compound or salt according to any one of claims 329 to 331, wherein each of these is substituted as necessary.

333. R １ The aforementioned one or more substituents as needed are halogens, 【Chemistry 1134】 , oxo, 【Chemistry 1135】 【Chemistry 1136】 and independently selected from 5- to 9-membered heteroaryls, wherein the 5- to 9-membered heteroaryl is at least one R １＊ Replaced by the R １＊ However, halogens, and C １～６ A compound or salt according to any one of claims 329 to 332, selected from alkyl groups.

334. R １ The aforementioned one or more substituents as needed are chlorine, 【Chemistry 1137】 , oxo, 【Chemical 1138】 A compound or salt according to any one of claims 329 to 333, independently selected from the above. 【Request Item 335】 【Chemistry 1139】 The compound or salt according to any one of claims 329 to 334.

336. R １００ but, 【Chemistry 1140】 Selected from, R １Ａ However, C １～６ Selected from alkyl, the C １～６ Alkyl groups, 1 or more R １１ Replaced as needed, R １Ａ Two R on the same atom １１ But together, C ３ ~C ６ Forming a carbon ring, the C ３ ~C ６ A carbon ring contains one or more R １１Ａ It is replaced as needed; or the R １Ａ and R １Ｂ However, together with the atoms they bond to, R １ Forms R １ However, it is a 6- to 10-membered heterocycle that is substituted as needed; R １Ｂ However, hydrogen and C １～６ Selected from alkyl groups; R １Ｃ However, C １～６ Selected from alkyl, the C １～６ Alkyl groups, 1 or more R １２ Replaced as needed, R １Ｃ Two R on the same atom １２ But together, C ３ ~C ６ Forming a carbon ring, the C ３ ~C ６ A carbon ring contains one or more R １２Ａ A compound or salt according to any one of claims 1, or 7 to 165, which is substituted as necessary.

337. R １００ but, 【Chemistry 1141】 (In the formula, R １Ａ C １～６ Selected from alkyl, the C １～６ Alkyl is one or more R １１ Replaced as needed, R １Ａ Two R on the same atom １１ Together, they form a non-substituted C ３ (Forms a carbocyclic ring); 【Chemistry 1142】 (In the formula, R １Ｃ C １～６ Selected from alkyl, the C １～６ Alkyl is one or more R １２ Replaced as needed, R １Ｃ Two R on the same atom １２ Together, they form a non-substituted C ３ (forming a carbocyclic ring); and 【Chemistry 1143】 (In the formula, R １Ａ and R １Ｂ Together with the atoms they bond to, R １ Forms R １ teeth, 【Chemistry 1144】 (Selected from, each of which is replaced as needed) A compound or salt according to claim 336, selected from the above.

338. Each R １１ However, it is selected from -CN, and R if necessary. １Ａ Two R on the same atom １１ However, together, it becomes a non-substituted C ３ Forming a carbon ring; Each R １２ However, it is selected from -CN, and R if necessary. １Ｃ Two R on the same atom １２ However, together, it becomes a non-substituted C ３ Forming a carbon ring; R １ The one or more substituents of the above are halogens, -OR ２０ ,-CN, oxo, C １～６ Alkyl, C １～６ Hydroxyalkyl and -C(O)N(R) ２０ ) ２ Selected independently of The compound or salt according to claim 336 or 337.

339. R １１ but, 【Chemistry 1145】 Selected from; R １２ but, 【Chemistry 1146】 Selected from; R １ The one or more substituents of the above are halogen, -OH, -CN, oxo, C １～６ Alkyl, C １～６ Hydroxyalkyl and -C(O)N(CH ３ ) ２ Selected independently of The compound or salt according to claim 338.

340. R １００ but, 【Chemistry 1147】 A compound or salt according to claim 339, selected from the above.

341. R １ However, selected from substituted 6- to 7-membered heterocycles, the 6- to 7-membered heterocycle is substituted with at least one -NHCN, and one or more C １～６ The compound or salt according to claim 241, further optionally substituted with alkyl.

342. R １ but, 【Chemical 1148】 A compound or salt according to claim 341, selected from the above.

343. R １ The compound or salt according to claim 241, selected from substituted crosslinked 8- to 9-membered heterocycles as needed.

344. R １ The aforementioned complex ring of is 【Chemistry 1149】 A compound or salt according to claim 342, selected from, each of which is substituted as necessary.

345. R １ The one or more substituents of the above are halogens, C １～６ Alkyl, -N(R ２０ ) ２ , and C １～６ A compound or salt according to claim 342 or 343, selected from aminoalkyl groups.

346. R １ but, 【Chemical 1150】 A compound or salt according to any one of claims 342 to 345, selected from the above.

347. R １ The compound or salt according to claim 241, wherein a bridged eight-membered heterocycle is selected as necessary, and the heterocycle contains a heteroatom selected from nitrogen.

348. R １ The aforementioned complex ring of is 【Chemistry 1151】 A compound or salt according to claim 346, selected from, each of which is substituted as necessary.

349. R １ The one or more substituents of C １～６ Alkyl, -N(R ２０ ) ２ , and C １～６ A compound or salt according to claim 347, selected from aminoalkyl groups.

350. R １ but, 【Chemistry 1152】 (Preferably, 【Chemistry 1153】 A compound or salt according to claim 347 or 348, selected from ).

351. R １００ or 【Chemistry 1154】 but, 【Chemistry 1155】 【Chemistry 1156】 【Chemistry 1157】 A compound or salt according to any one of claims 1 to 169, selected from the above.

352. R １００ but, 【Chemical Formula 1158】 The compound or salt according to any one of claims 1 to 2 or 7 to 165.

353. Equation (I) is, 【Chemistry 1159】 The compound or salt according to claim 352, or represented by a pharmaceutically acceptable salt thereof.

354. Equation (I) is, 【Chemistry 1160】 The compound or salt according to claim 352, or represented by a pharmaceutically acceptable salt thereof.

355. Equation (I) is, 【Chemistry 1161】 The compound or salt according to claim 352, or represented by a pharmaceutically acceptable salt thereof.

356. R １Ｃ However, C was replaced as needed. １～６ A compound or salt according to any one of claims 352 to 355, selected from alkyl groups.

357. R １Ｃ However, C was replaced as needed. １～６ Selected from alkyl groups, and R as needed. １Ｃ Two R on the same atom １２ However, together, C is replaced as needed. ３ ~C ６ A compound or salt according to any one of claims 352 to 356, which forms a carbon ring.

358. R １２ However, it is selected from -OH and -CN, R １Ｃ Two R on the same atom １２ However, together, it becomes a non-substituted C ３ The compound or salt according to claim 358, which forms a carbon ring.

359. R １Ｃ but, 【Chemistry 1162】 A compound or salt according to any one of claims 352 to 355, selected from the above. [Request Item 360] [Chemistry 1163] but, 【Chemistry 1164】 A compound or salt according to any one of claims 352 to 355, selected from the above.

361. R １Ｃ The compound or salt according to any one of claims 352 to 355, selected from substituted 5- to 6-membered heterocycles as needed.

362. R １Ｃ The compound or salt according to claim 361, selected from optionally substituted five-membered heterocycles having at least one oxygen atom.

363. R １Ｃ but, 【Chemistry 1165】 A compound or salt according to any one of claims 361 to 362, selected from and which is substituted as necessary.

364. Each R １２ However, halogen, -OR ２０ , C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl and C １～６ A compound or salt according to claim 363, selected from alkyl groups.

365. Each R １２ The compound or salt according to claim 364, selected from -OH.

366. R １Ｃ but, 【Chemical 1166】 The compound or salt according to any one of claims 361 to 365.

367. R １００ but, 【Chemistry 1167】 The compound or salt according to claim 1.

368. R １００ but, 【Chemical 1168】 The compound or salt according to claims 1 to 2, or 7 to 165.

369. Equation (I) is, 【Chemistry 1169】 The compound or salt according to claim 368, or represented by a pharmaceutically acceptable salt thereof.

370. Equation (I) is, 【Chemistry 1170】 The compound or salt according to claim 368, or represented by a pharmaceutically acceptable salt thereof.

371. Equation (I) is, 【Chemistry 1171】 The compound or salt according to claim 368, or represented by a pharmaceutically acceptable salt thereof.

372. R １Ｄ However, C was replaced as needed. １～６ A compound or salt according to any one of claims 1 or 368 to 371, selected from alkyl groups.

373. R １Ｄ However, C was replaced as needed. １～６ Selected from alkyl groups, and R as needed. １Ｄ Two R on the same atom １３ However, together, C is replaced as needed. ３ ~C ６ A compound or salt according to any one of claims 368 to 372, which forms a carbon ring.

374. R １３ However, it is selected from -OH and -CN, R １Ｄ Two R on the same atom １３ However, together, it becomes a non-substituted C ３ A compound or salt according to claim 373 that forms a carbon ring.

375. Formula (I-C ＊ ) Compounds: 【Chemistry 1172】 or a pharmaceutically acceptable salt thereof [in the formula, R １Ａ C １～６ Alkyl, C ３ ~C １２ Selected from carbon rings and 4- to 12-membered heterocycles, each of which has one or more R １１ Replaced as needed, R １Ａ Two R on the same atom １１ Together, C ３ ~C ６ Forming a carbon ring or a 3- to 8-membered heterocycle, the C ３ ~C ６ The carbon ring and the 3- to 8-membered heterocycle have one or more R １１Ａ Each is replaced as needed; R １Ｂ is hydrogen, C １～６ Alkyl, C ３ ~C ６ Selected from a carbon ring or a 4- to 6-membered heterocycle, the C １～６ Alkyl, C ３ ~C ６ Carbon rings and 4- to 6-membered heterocycles have one or more R １０ Are they replaced as needed? Or R １Ａ and R １Ｂ Together with the atoms they bond to, R １ Forms R １ This is a 5- to 15-membered heterocycle, and the 5- to 15-membered heterocycle is a halogen, -B (OR ２０ ) ２ , -N(R ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -C(=NR ２０ )N(R ２０ ) ２ , -C １～６ Alkyl (=NR ２０ OR ２０ ), -C(O)NR ２０ OR ２０ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = N (R ２０ ), = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl-SO ２ R ２０ , C １～６ Alkoxyalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C １２ The C is optionally substituted with one or more substituents independently selected from a carbon ring and a 5- to 12-membered heterocycle. ３ ~C １２ The carbon ring and the 5- to 12-membered heterocycle have one or more R １＊ They are independently replaced as needed; Each R １＊ is halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -C(O)NR ２０ OR ２０ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = N (R ２０ ), = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl and C ３ ~C １２ Selected independently from the carbocyclic ring; Y is -O-; R ２ is a heteroalgebra, a -L-heteroalgebra, a -L-N(R) ２０ ) ２ , -L-OR ２０ -L-aryl, -L-heteroaryl, -L-cycloalkyl, -L-NHC(=NH)NH ２ , -LC(O)N(R ２０ ) ２ , -L-C １ ~C ６ Haloalkyl, -L-NR ２０ C(O)-aryl, -L-COOH, -L-NR ２０ S(O) ２ (R ２０ ), -L-S(O) ２ N(R) ２０ ) ２ , -L-N(R ２０ ) C(O)(OR ２０ ), -L-OC(O)N(R ２０ ) ２ , and -L-C(=O)OC １ ~C ６ Selected from alkyl groups, the heterocycle, the heterocyclic portion of the -L-heterocycle, and the cycloalkyl portion of the -L-cycloalkyl group are one or more R ６ These are replaced as needed, -L-NR ２０ The aryl portion of C(O)-aryl, the aryl portion of -L-aryl, and the heteroaryl portion of -L-heteroaryl are one or more R ７ Each is replaced as needed; Each L represents halogen, hydroxyl, and C. １～６ Alkoxy, C １ ~C ４ Hydroxyalkyl, C １ ~C ４ Alkyl, C ３ ~C ６ A carbon ring and a carbon ring optionally substituted with one or more substituents independently selected from 3- to 8-membered heterocycles. １ ~C ４ Selected independently from alkylene, the C ３ ~C ６ Carbon rings and 3- to 8-membered heterocycles are halogens, -OH, and -NO. ２ , =O, =S, -CN,C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Each is optionally substituted with one or more substituents independently selected from the haloalkyl; optionally, two substituents on the same carbon atom of L are combined to form C ３ ~C ６ Forming a carbon ring or a 3- to 8-membered heterocycle, the C ３ ~C ６ Carbon rings and 3- to 8-membered heterocycles are halogens, -OH, and -NO. ２ , =O, =S, -CN,C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, and C １～６ Each substituent is optionally substituted with one or more substituents independently selected from the haloalkyl group; Each R ５ is hydrogen and C １ ~C ６ Selected independently of alkyl; Each R ６ is halogen, hydroxy, C １ ~C ３ Hydroxyalkyl, C １ ~C ３ Alkyl, oxo, C １ ~C ３ Haloalkyl, C １ ~C ３ Alkyl-N ３ , C １ ~C ３ Alkoxy, cyano, =CH ２ , = NO-C １ ~C ３ Alkyl, C １ ~C ３ Aminoalkyl, -N(R) ５ ) S(O) ２ (R ５ ), -Q-phenyl, -Q-phenylSO ２ F,-NHC(O)phenyl,-NHC(O)phenylSO ２ F, C １ ~C ３ Alkyl-substituted pyrazolyl, tert-butyldimethylsilyloxy CH ２ -, -N(R ５ ) ２ , (C １ ~C ３ Alkoxy) C １ ~C ３ Alkyl-, (C １ ~C ３ Alkyl) C (= O), oxo, (C １ ~C ３ Haloalkyl)C(=O)-, -SO ２ F, (C １ ~C ３ Alkoxy) C １ ~C ３ Alkoxy, -CH ２ OC(O)NCF ３ (R ５ ), -CH ２ O-C １ ~C ６ Alkyl, -CH ２ OC(O)N(R) ５ ) ２ ien-CH ２ NHC(O)OC １ ~C ６ Alkyl, -CH ２ NHC(O)N(R) ５ ) ２ ien-CH ２ NHC(O)C １ ~C ６ Alkyl, -CH ２ (Pyrazolyl), -CH ２ NHSO ２ C １ ~C ６ Alkyl, -CH ２ OC(O) heteroalgebra, -OC(O)N(R ５ ) ２ , -OC(O)NH(C １ ~C ３ Alkyl)O(C １ ~C ３ Alkyl), -OC(O)NH(C １ ~C ３ Alkyl)O(C １ ~C ３ Alkyl)phenyl (C １ ~C ３ Alkyl)N(CH ３ ) ２ , -OC(O)NH(C １ ~C ３ Alkyl)O(C １ ~C ３ Alkyl)phenyl, -OC(O) heterocycle, -O-C １ ~C ３ Alkyl, -O-C １ ~C ６ Haloalkyl, -C １ ~C ３ Alkyl-O-C １ ~C ６ Haloalkyl, C １～６ Alkyl-N(R) ２０ ) ２ , -SF ５ , -C １ ~C ３ Alkyl-N ３ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ ,-(CH ２ ) ０～１ S-heterogenetic ring, -(CH ２ ) ０～１ -O- Heterogeneous ring, -(CH ２ ) ０～１ -O-phenyl and -CH ２ Selected independently from complex algebras, -NHC(O)phenyl and -OC(O)NH(C １ ~C ３ (Alkyl) (C １ ~C ３ The phenyl in alkyl(phenyl)phenyl is optionally substituted with one or more substituents selected from -C(O)H and OH. -O-C １ ~C ３ The alkyl group of the alkyl group is optionally substituted with substituents selected from heterocyclic, oxo, and hydroxyl groups; -CH ２ O-C １ ~C ６ The alkyl in alkyl refers to halogens and C ３ ~C ６ Substituted as needed with one or more substituents selected from the carbocyclic; -CH ２ The complex ring of a complex ring is substituted with oxos as needed; - (CH ２ ) ０～１ -O-phenyl's phenyl is C １～６ Alkyl, C １～６ Haloalkyl, SF ５ , C １～６ Alkyl-OR ２０ , -OR ２０ Substituting as necessary with one or more substituents selected from; - (CH ２ ) ０～１ -O- Heterocyclic rings and -(CH ２ ) ０～１ The complex algebra of -S- is C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkyl-OR ２０ , and -OR ２０ Each substituent is optionally replaced by one or more substituents selected from; Each Q is selected from combinations and O; Each R ７ is halogen, hydroxyl, HC(=O)-, C １ ~C ４ Alkyl, C １ ~C ４ Alkoxy, C １ ~C ４ Haloalkyl, C １ ~C ４ Hydroxyalkyl and -N(R ５ ) ２ Selected independently of; B is a 7- to 15-membered heterocyclic ring and C ７ ~C １５ Selected from carbon rings, the aforementioned 7-15 membered heterocycles and C ７ ~C １５ The carbon ring consists of halogens, -CN, and -NO. ２ , = O, -N(R ２０ ) ２ , -B(OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -C(O)NR ２０ OR ２０ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Alkoxyalkyl, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C １２ Each is optionally substituted with one or more substituents independently selected from the carbocyclic and 5- to 12-membered heterocycles; Each R １０ is halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C １２ A carbon ring and a 5- to 12-membered heterocycle are independently selected, and the C ３ ~C １２ Carbon rings and 5- to 12-membered heterocycles include halogens, -OH, -CN, and -NO. ２ , -NH ２ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , C １～１０ Alkyl, -C １～１０ Haloalkyl, -O-C １～１０ Each substituent is optionally substituted with one or more substituents independently selected from alkyl and oxo; Each R １１ is halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NR ２０ (C=NH)N(R) ２０ ) ２ , -NO ２ , = O, = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C １２ A carbon ring and a 5- to 12-membered heterocycle are independently selected, and the C ３ ~C １２ Carbon rings and 5- to 12-membered heterocycles include halogens, -OH, -CN, and -NO. ２ , -N(R ２１ ) ２ ,-SR ２１ , -C(O)N(R ２１ ) ２ , C １～１０ Alkyl, -C １～１０ Haloalkyl, -O-C １～１０ Alkyl, -S(O) ２ (R ２１ ), -P(O)(OR ２１ ) ２ , -OP(O)(OR ２１ ) ２ , -P(O)(R ２１ ) ２ , and each may be optionally substituted with one or more substituents independently selected from the oxo; Each R １１Ａ is halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -S(O) ２ (R ２０ ), -S(O) ２ N(R) ２０ ) ２ , -S(O)N(R ２０ ) ２ , -S(O)R ２０ (=NR ２０ ), -NR ２０ S(O) ２ R ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Selected independently of Alkinnil; Each R ２０ hydrogen; and each of them is a halogen, -OH, -CN, -NO ２ , -NH ２ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , C １～１０ Alkyl, C １～１０ Haloalkyl, -O-C １～１０ Alkyl, oxo, C ３～１２ A carbon ring and a carbon ring optionally substituted with one or more substituents independently selected from 3- to 12-membered heterocycles. １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１２ Independently selected from carbon rings and 3- to 12-membered heterocycles; Each R ２１ hydrogen; and each of them is a halogen, -OH, -CN, -NO ２ , -NH ２ , -N(C １～６ Alkyl) ２ , C １～１０ Alkyl, -C １～１０ Haloalkyl, -O-C １～１０ Alkyl, oxo, C ３～１２ A carbon ring and a carbon ring optionally substituted with one or more substituents independently selected from 3- to 12-membered heterocycles. １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１２ [Independently selected from carbon rings and 3- to 12-membered heterocycles.]

376. R １Ａ However, C １～３ Alkyl, C ３ ~C ９ Selected from carbon rings and 4- to 8-membered heterocycles, each of which contains one or more R １１ Replaced as needed, R １Ａ Two R on the same atom １１ But together, C ３ ~C ６ Forming a carbon ring or a 3- to 8-membered heterocycle, the C ３ ~C ６ A carbon ring and a 3- to 8-membered heterocycle are present in one or more R １１Ａ Each is replaced as needed; R １Ｂ However, hydrogen, C １～３ Alkyl, C ３ ~C ５ Selected from a carbon ring or a 4- to 6-membered heterocycle, the C １～６ Alkyl, C ３ ~C ６ A carbon ring and a 4- to 6-membered heterocycle are present in one or more R １０ Are they replaced as needed? Or R １Ａ and R １Ｂ However, together with the atoms they bond to, R １ Forms R １ However, it is a 5- to 9-membered heterocycle, and the 5- to 9-membered heterocycle is a halogen, -B (OR ２０ ) ２ , -N(R ２０ ) ２ , -OR ２０ ,-SR ２０ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)OR ２０ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = N (R ２０ ), = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkoxyalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C ６ The C is optionally substituted with one or more substituents independently selected from a carbon ring and a 5- to 7-membered heterocycle. ３ ~C ６ A carbon ring and a 5- to 7-membered heterocycle are present in one or more R １＊ They are independently substituted as needed; each R １＊ However, halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -C(O)N(R ２０ ) ２ , -C(O)NR ２０ OR ２０ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = N (R ２０ ), = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl and C ３ ~C ６ Selected independently from the carbon ring; B is selected from a 7- to 9-membered heterocycle, and the 7- to 9-membered heterocycle is -CN, -NH ２ , and C １～６ Optionally substituted with one or more substituents independently selected from the alkyl group; Y is -O-; R ２ However, the -L-heterogene and -L-N(CH) ３ ) ２ Selected from, the heterocyclic portion of the -L-heterocyclic ring is one or more R ６ Replaced as needed; Each L is C １ ~C ４ C as needed, substituted with one or more substituents independently selected from alkyl １ ~C ４ Independently selected from alkylenes; if necessary, two substituents on the same carbon atom of L, together, C ３ ~C ４ Forming a carbon ring or a four-membered heterocycle, the C ３ ~C ４ The carbon ring and the four-membered heterocycle are optionally substituted with one or more substituents independently selected from the halogen; Each R ６ However, halogen, C １ ~C ３ Hydroxyalkyl, C １ ~C ３ Alkyl, oxo, C １ ~C ３ Haloalkyl, =CH ２ , (C １ ~C ３ Alkoxy) C １ ~C ３ Alkyl- and -CH ２ -O- Selected independently from the complex algebra, -CH ２ -O- The complex ring of the complex ring is C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkyl-OR ２０ , and -OR ２０ Substituting as necessary with one or more substituents selected from; Each R １０ However, halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C ６ A carbon ring and a 5- to 7-membered heterocycle are independently selected, and the C ３ ~C ６ The carbon ring and 5- to 7-membered heterocycles are halogens, -OH, -CN, and -NO. ２ , -NH ２ ,-NH(C １～６ Alkyl), -N(C １～６ Alkyl) ２ , C １～５ Alkyl, -C １～５ Haloalkyl, -O-C １～５ Each substituent is optionally substituted with one or more substituents independently selected from alkyl and oxo; Each R １１ However, halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -NO ２ , = O, = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３ ~C ６ A carbon ring and a 5- to 9-membered heterocycle are independently selected, and the C ３ ~C ６ The carbon ring and 5- to 9-membered heterocycles are halogens, -OH, -CN, and -NO. ２ , -N(R ２１ ) ２ ,-SR ２１ , -C(O)N(R ２１ ) ２ , C １～５ Alkyl, -C １～５ Haloalkyl, -O-C １～５ Alkyl, -S(O) ２ (R ２１ ), -P(O)(OR ２１ ) ２ , -OP(O)(OR ２１ ) ２ , -P(O)(R ２１ ) ２ , and each may be optionally substituted with one or more substituents independently selected from the oxo; Each R １１Ａ However, halogen, -B (OR ２０ ) ２ , -OR ２０ ,-SR ２０ , -C(O)N(R ２０ ) ２ , -N(R ２０ ) C(O)R ２０ , -N(R ２０ ) C(O)OR ２０ , -N(R ２０ ) ２ , -C(O)R ２０ , -C(O)OR ２０ , -OC(O)R ２０ , -OC(O)N(R ２０ ) ２ , -NO ２ , = O, = NO (R ２０ ), -CN, -NHCN, C １～６ Alkyl-N(R) ２０ ) ２ , C １～６ Aminoalkyl, C １～６ Alkoxy, C １～６ Hydroxyalkyl, C １～６ Cyanoalkyl, C １～６ Haloalkyl, C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Selected independently of alkinyl, The compound or salt according to claim 375. 【Request Item 377】 【Chemistry 1173】 but, 【Chemistry 1174】 Represented by; Y-R ２ but,: 【Chemistry 1175】 【Chemistry 1176】 Selected from; 【Chemistry 1177】 but, 【Chemistry 1178】 【Chemistry 1179】 Selected from, The compound or salt according to claim 375 or 376.

378. A pharmaceutical composition comprising a compound or salt according to any one of claims 1 to 377, and a pharmaceutically acceptable additive.

379. A method for treating a disease or disorder, comprising administering a compound or salt according to any one of claims 1 to 377, or a pharmaceutical composition according to claim 378, to a subject in need thereof.

380. A method for treating a disease or disorder, comprising using a compound or salt according to any one of claims 1 to 377, or a pharmaceutical composition according to claim 378.

381. A method for inhibiting KRas G12D and / or other G12 mutants, comprising using a compound or salt according to any one of claims 1 to 377, or a pharmaceutical composition according to claim 378.

382. A method for inhibiting KRas G12D and / or other G12 alleles, comprising using a compound or salt according to any one of claims 1 to 377, or a pharmaceutical composition according to claim 378.

383. A method for inhibiting KRas G12D and / or other alleles, comprising using a compound or salt according to any one of claims 1 to 377, or a pharmaceutical composition according to claim 378.

384. The method according to claim 379, wherein the disease or disorder is a KRas G12D mutant-associated cancer.

385. The method according to claim 379, wherein the disease or disorder is a KRas G12V mutant-associated cancer.

386. The aforementioned disease or disorder Heart: Sarcomas (angiosarcoma, fibrosarcoma, rhabdomyosarcoma, liposarcoma), myxoma, rhabdomyomas, fibromas, lipomas, and teratomas; Lungs: Bronchial cancer (squamous cell carcinoma, anaplastic small cell carcinoma, anaplastic large cell carcinoma, adenocarcinoma), alveolar (bronchial) carcinoma, bronchial adenoma, sarcoma, lymphoma, chondrotoxic hamartoma, mesothelioma; Gastrointestinal tract: Esophagus (squamous cell carcinoma, adenocarcinoma, leiomyosarcoma, lymphoma), stomach (carcinoma, lymphoma, leiomyosarcoma), pancreas (ductal adenocarcinoma, insulinoma, glucagonoma, gastrinoma, carcinoid tumor, vipoma), small intestine (adenocarcinoma, lymphoma, carcinoid tumor, Kaposi's sarcoma, leiomyoma, hemangioma, lipoma, neurofibroma, fibroma), large intestine (adenocarcinoma, tubular adenoma, chorioadenoma, hamartoma, leiomyoma); Urogenital tract: kidney (adenocarcinoma, Wilms' tumor (nephroblastoma), lymphoma, leukemia), bladder and urethra (squamous cell carcinoma, transitional cell carcinoma, adenocarcinoma), prostate (adenocarcinoma, sarcoma), testes (seminocarcinoma, teratoma, embryonic carcinoma, teratocarcinoma, choriocarcinoma, sarcoma, stromal cell carcinoma, fibroma, fibroadenoma, adenomatous tumor, lipoma); Liver: Hepatocellular carcinoma, cholangiocarcinoma, hepatoblastoma, angiosarcoma, hepatocellular adenoma, hemangioma; Bile duct: gallbladder cancer, ampulla cancer, cholangiocarcinoma; Bone: Osteogenic sarcoma (osteosarcoma), fibrosarcoma, malignant fibrous histiocytoma, chondrosarcoma, Ewing's sarcoma, malignant lymphoma (reticulum sarcoma), multiple myeloma, malignant giant cell tumor, chordoma, osteochondroma (chondrodystostoma), benign chondroma, chondroblastoma, chondromyxofibroma, osteoid osteoma and giant cell tumor; Nervous system: Skull (osteoma, hemangioma, granuloma, xanthomas, degenerative osteitis), meninges (meningioma, meningiosarcoma, glioma), brain (astrocytoma, medulloblastoma, glioma, ependymoma, germ cell tumor (pineal glandoma), glioblastoma multiforme, oligodendroglioma, Schwann cell tumor, retinoblastoma, congenital tumor), spinal neurofibroma, meningioma, glioma, sarcoma); Gynecology: Uterus (endometrial cancer), cervix (cervical cancer, preneoplastic cervical dysplasia), ovaries (ovarian cancer (serous cystadenocarcinoma, mucinous cystadenocarcinoma, unclassifiable carcinoma), granulosacytic cell tumor, Sertley-Leydig cell tumor, undifferentiated germ cell tumor, malignant teratoma), vulva (squamous cell carcinoma, carcinoma in situ, adenocarcinoma, fibrosarcoma, melanoma), vagina (clear cell carcinoma, squamous cell carcinoma, staphylosarcoma (embryonic rhabdomyosarcoma), fallopian tube (carcinoma); Hematology: Blood (myeloid leukemia (acute and chronic), acute lymphoblastic leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, multiple myeloma, myelodysplastic syndromes), Hodgkin's disease, non-Hodgkin lymphoma (malignant lymphoma); Skin: malignant melanoma, basal cell carcinoma, squamous cell carcinoma, Kaposi's sarcoma, dysplastic nevi, lipoma, hemangioma, dermatofibroma, keloid, psoriasis; and Adrenal gland: Neuroblastoma The method according to any one of claims 377 to 385, wherein the cancer is selected from the following.

387. The method according to claim 386, wherein the disease or disorder is cancer, and the cancer is non-small cell lung cancer, small cell lung cancer, colorectal cancer, rectal cancer, or pancreatic cancer; or the cancer is a tumor cancer.

388. Use of a compound according to any one of claims 1 to 376 in the preparation of a compound that degrades a target protein by using a chemical modification of the compound according to any one of claims 1 to 376.

Images