Atomizable and inhalable liquid formulations, cartridges, and aerosol generating systems
A liquid formulation of ambroxol hydrochloride for electronic atomizers achieves high atomization efficiency and deep lung deposition, addressing portability and azeotrope issues in existing devices, improving therapeutic efficacy.
Patent Information
- Application Number
- JP2025556995
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-03-31
- Filing Date
- 2024-03-27
- Publication Date
- 2026-04-14
AI Technical Summary
Existing medical nebulizer devices for ambroxol hydrochloride administration are not portable, limiting their use and efficacy, and current electronic atomizers operate at temperatures that can cause azeotrope formation with ambroxol hydrochloride, affecting atomization efficiency.
A liquid formulation of ambroxol hydrochloride is prepared for use with electronic atomizers, achieving an atomization conversion rate of 90% or more, utilizing solvents like propylene glycol and vegetable glycerin to enhance solubility and stability, and employing electronic atomizers that heat the liquid to its boiling point for aerosol generation.
The solution enables efficient aerosol generation with particles ≤1 μm, allowing deep lung deposition, reduced oral residue, and improved user compliance, enhancing therapeutic effects for respiratory diseases.