A method for evaluating splice switching ASO features

A method for evaluating ASO delivery and splice-switching activity in transgenic models using a reporter protein sequence enables high-throughput assessment, addressing the limitations of current methods and facilitating disease treatment development.

JP2026520051APending Publication Date: 2026-06-19GENENTECH INC +1
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
GENENTECH INC
Filing Date
2024-06-13
Publication Date
2026-06-19

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Abstract

A method for evaluating splice-switching ASOs is provided herein, which uses a reporter to detect splicing of a cryptic sequence located in a reporter premRNA.
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