Method and detection apparatus for determining the concentration of a substance

The method uses PPG to measure blood glucose by analyzing the noise spectrum in PPG data, addressing the limitations of current monitoring techniques with continuous, non-invasive glucose monitoring.

JP2026521637APending Publication Date: 2026-06-30エーエムエス-オスラム·アーゲー
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
エーエムエス-オスラム·アーゲー
Filing Date
2024-11-07
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Current blood glucose monitoring methods, including invasive and non-invasive techniques, face challenges such as the need for finger pricking, risk of infection, and variable signal quality due to skin type and environmental factors, making continuous monitoring difficult.

Method used

A method utilizing photoplethysmography (PPG) to measure the perfusion index (PI) and extract noise spectrum from PPG data to determine blood glucose concentration, leveraging the correlation between noise level and glucose concentration, based on the Beer-Lambert law and optical properties of blood.

Benefits of technology

Enables continuous, non-invasive monitoring of blood glucose levels by accurately correlating noise levels in PPG signals with glucose concentration, providing reliable measurements even in noisy environments.

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Abstract

The present invention relates to a method for determining the concentration of a substance in a sample, particularly a liquid containing particles, blood glucose, wherein the refractive index of the liquid depends on the concentration of the substance dissolved therein, and the density of the liquid particles is substantially constant. The method includes the steps of acquiring a first signal of PPG during a first period, and estimating at least a portion of the noise spectrum from the acquired first signal, particularly in the frequency domain. At least a portion of the noise spectrum is used to derive the substance concentration or a change in substance concentration.
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