Selenium-containing capsule structure
By employing a selenium-rich spirulina extract in an aqueous solution within the capsule structure, the selenium content can be accurately controlled, addressing distribution and bioavailability issues in existing selenium-containing health foods.
Patent Information
- Application Number
- JP2025000729U
- Authority / Receiving Office
- JP · JP
- Patent Type
- Utility models
- Current Assignee / Owner
- Priority Date
- 2024-10-18
- Filing Date
- 2025-03-07
- Publication Date
- 2025-05-08
- Estimated Expiration
- 2035-03-07
AI Technical Summary
Current selenium-containing health foods face challenges in ensuring even selenium distribution within capsules due to the use of powdered selenium materials, leading to potential overdose and difficulties in accurately measuring selenium content, which poses food safety concerns.
The selenium-containing capsule structure utilizes an aqueous solution of a selenium-rich water extract of spirulina instead of water, allowing for precise adjustment of selenium concentration and incorporation of selenocysteine, which is more easily absorbed by the human body.
This approach ensures accurate and even selenium content in capsules, reduces the risk of overdose, and enhances bioavailability, particularly benefiting vegetarians, while maintaining compatibility with existing manufacturing processes.
Smart Images
Figure 0003251196000001_ABST
Abstract
Description
[Technical field]
[0001] The present invention relates to a selenium-containing capsule structure. [Background technology]
[0002] Selenium is one of 14 trace elements necessary for the growth of humans and animals. It has a strong antioxidant effect and also has functions such as delaying aging, improving thyroid function, improving male infertility, protecting the liver, reducing the incidence of cancer, preventing cardiovascular disease and diabetes, promoting weight loss, and regulating the immune system.
[0003] The recommended daily intake of selenium for adults is 55 micrograms (μg) to 400μg. Although selenium is generally found in meat and seafood, Taiwan has a large vegetarian population, and therefore may have a problem with insufficient selenium intake. On the other hand, if the human body ingests high concentrations of selenium, symptoms such as nausea, vomiting, and diarrhea may appear in mild cases, and symptoms such as arrhythmia, hemolysis, liver necrosis, pulmonary edema, and cerebral edema may appear in severe cases, and in severe cases, death may occur. And if high concentrations of selenium are ingested for a long period of time, it may cause chronic selenium poisoning, the symptoms of which include hair loss, weakening and falling of nails, gastrointestinal discomfort, baldness, skin rash, fatigue, liver damage, and even nervous system abnormalities (numbness and weakness of the limbs, etc.). Therefore, how to accurately replenish the appropriate amount of selenium is an important issue in health foods. Summary of the Invention [Problem to be solved by the invention]
[0004] At present, most of the selenium-containing health foods on the market are soft or hard capsules that contain selenium-containing health ingredients, and these health ingredients are in powder or liquid form (oil or water), which may cause technical problems during the manufacturing process. At present, the amount of selenium supplemented is at the microgram level, and the traditional selenium materials are in powder form (its salts or extracts are all dry powders), and the volume of each drug (e.g., tablet or capsule) is quite small. Therefore, when manufacturing drugs (e.g., filling them into capsules), the selenium content of each drug (e.g., capsule) may not be uniform due to the distribution of selenium-containing powder throughout the powder material, and additional processing may be required. Furthermore, even a slight excess of selenium may cause poisoning, so it is difficult to accurately measure the selenium content of each capsule when manufacturing capsules, and the traditional process is not precise enough, which may cause food safety concerns. [Means for solving the problem]
[0005] In view of the deficiencies of the current technology, the present invention aims to provide a selenium-containing capsule structure, which is manufactured by using an aqueous solution of selenium-rich spirulina water extract instead of water, and by adjusting the concentration of the selenium-rich spirulina water extract, the concentration of selenocysteine in the capsule structure can be adjusted, so that the selenium content in each capsule can be accurately determined, and food safety concerns can be reduced. In addition, the selenocysteine contained in the capsule structure of the present invention is derived from selenium-rich spirulina, so it is more easily absorbed by the human body than inorganic selenium, and can be used to manufacture nutritional supplements for vegetarians. In addition, the technology of the present invention can be combined with the existing soft or hard capsule manufacturing process, and there is no need to add or adjust equipment, so no extra costs are incurred.
[0006] To achieve the above object, the present invention provides a selenium-containing capsule structure comprising a shell containing a selenium compound, a selenium-containing composition or a combination thereof, and a receiving space located inside the shell.
[0007] In some specific embodiments, the selenium compound is selected from the group consisting of, but not limited to, sodium selenate, sodium selenite, selenium dioxide, selenium citrate, selenium amino acids, small molecule selenoproteins, selenium polysaccharides, and combinations thereof, and the selenium concentration in the shell is 0.1 mg / kg-5000 mg / kg.
[0008] In some specific embodiments, the selenium amino acid is selenomethionine, selenocysteine, or a combination thereof.
[0009] In some specific embodiments, the selenium-containing composition is a selenium-containing nutrient, the selenium-containing nutrient comprising selenium yeast, plant selenium, nano-selenium, cyanobacteria extract or a combination thereof, and the selenium concentration in the shell is 0.1 mg / kg to 5000 mg / kg.
[0010] In the present invention, "nano selenium" refers to a composition containing selenium nanoparticles, which is composed of selenium nanoparticles and a dispersant. In some specific embodiments, the particle size of the selenium nanoparticles is 30nm-250nm, 50nm-200nm, or 100nm-150nm. In some specific embodiments, the selenium concentration of the nano selenium is 100ppm-1000ppm, 200ppm-900ppm, 300ppm-800ppm, 400ppm-700ppm, or 500ppm-600ppm.
[0011] In some specific embodiments, the selenium-containing composition is an aqueous extract of selenium-rich cyanobacteria. In some specific embodiments, the aqueous extract of selenium-rich cyanobacteria is an aqueous extract of selenium-rich spirulina. In the present invention, "selenium-rich cyanobacteria" refers to cyanobacteria cultured in a selenium-containing aqueous solution, and "selenium-rich spirulina" refers to Spirulina spp. cultured in a selenium-containing aqueous solution. In some specific embodiments, "selenium-rich spirulina" refers to spirulina obtained by culturing in an aqueous solution containing nanoselenium at a concentration of 500 mg / kg to 1000 mg / kg for 12 to 72 hours, 24 to 60 hours, or 36 to 48 hours. In some specific examples, the "selenium-rich spirulina" is spirulina obtained by culturing in an aqueous solution containing nanoselenium at a concentration of 600 mg / kg to 950 mg / kg for 12 to 72 hours, 24 to 60 hours, or 36 to 48 hours. In some specific examples, the "selenium-rich spirulina" is spirulina obtained by culturing in an aqueous solution containing nanoselenium at a concentration of 700 mg / kg to 950 mg / kg for 12 to 72 hours, 24 to 60 hours, or 36 to 48 hours. In some specific examples, the selenium-rich spirulina is spirulina obtained by culturing in an aqueous solution containing nanoselenium at a concentration of 800 mg / kg to 900 mg / kg for 12 to 72 hours, 24 to 60 hours, or 36 to 48 hours. Selenium-rich cyanobacteria can be obtained under the above-mentioned culturing conditions.
[0012] In some specific embodiments, the selenium-rich spirulina water extract is prepared by the following steps: (1) Prepare selenium-rich spirulina. (2) The selenium-rich spirulina is crushed and sieved through a sieve having a mesh size of 100 to 200 to obtain pieces of selenium-rich spirulina. (3) The selenium-rich spirulina pieces are placed in water and stirred at room temperature for 0.5 to 2 hours to obtain an aqueous solution of the selenium-rich spirulina water extract, and the weight ratio of the selenium-rich spirulina pieces to secondary water is 1:1 to 1:5. (4) After drying the aqueous solution of the selenium-rich spirulina water extract, the selenium-rich spirulina water extract is obtained.
[0013] In some specific embodiments, the selenium-rich spirulina in step (1) is drained selenium-rich spirulina. In some specific embodiments, the selenium-rich spirulina in step (1) is not treated by a drying process. In some specific embodiments, the weight of the selenium-rich spirulina pieces in step (2) is a wet weight.
[0014] In some specific embodiments, the weight ratio of the selenium-rich spirulina pieces to the secondary water in step (3) is 1:2 to 1:3. In some specific embodiments, the weight ratio of the selenium-rich spirulina pieces to the secondary water in step (3) is 1:2.
[0015] In some specific embodiments, the aqueous solution of the selenium-rich Spirulina water extract obtained in step (3) is used to prepare capsules, and the drying step in step (4) is carried out in the process of forming capsules. In some specific embodiments, the aqueous solution of the selenium-rich Spirulina water extract obtained in step (3) is used to prepare capsules after dilution or concentration.
[0016] In some specific embodiments, the selenium-rich spirulina water extract obtained in step (4) is dissolved in water and then used to prepare capsules.
[0017] In some specific embodiments, the selenium concentration in the shell is 0.1 milligrams per kilogram (mg / kg) to 5000 mg / kg, 0.2 μg / kg to 4000 μg / kg, 0.3 μg / kg to 3000 μg / kg, 0.5 μg / kg to 2000 μg / kg, 0.5 μg / kg to 1000 μg / kg, 0.5 μg / kg to 500 μg / kg, 0.5 μg / kg to 100 μg / kg, or 0.5 μg / kg to 10 μg / kg.
[0018] In some specific embodiments, the storage space is filled with a content, and the content is a powder or a liquid. In some specific embodiments, the liquid may be an oily liquid or a watery liquid. In some specific embodiments, the liquid may be oil, water, or a combination thereof.
[0019] In some specific embodiments, the capsule structure is a soft capsule structure. In some specific embodiments, the capsule structure is a soft capsule structure and the shell is a sealed shell.
[0020] In some specific embodiments, the capsule structure is a hard capsule structure, and the shell comprises a first capsule shell and a second capsule shell, and the first capsule shell and the second capsule shell are fitted together to form the containing space.
[0021] In some specific embodiments, the shell is prepared from a first blend solution, the first blend solution comprising 1 wt%-20 wt% gelatin, 8 wt%-60 wt% swelling agent, 8 wt%-40 wt% plasticizer, 15 wt%-75 wt% selenium-containing aqueous solution, and 1 wt%-2 wt% titanium dioxide, and the selenium concentration in the selenium-containing aqueous solution is 0.1 mg / kg-5000 mg / kg.
[0022] In some specific embodiments, the shell is prepared from a second blended solution, which includes 0.1 wt % to 18 wt % of a hydrophilic gel, 62 wt % to 96 wt % of a binder, 0.1 wt % to 5 wt % of a plasticizer, 0.01 wt % to 5 wt % of a flocculation aid, and 3 wt % to 10 wt % of a selenium-containing aqueous solution, and the selenium concentration in the selenium-containing aqueous solution is 0.1 mg / kg to 5000 mg / kg.
[0023] In some specific embodiments, the selenium concentration in the selenium-containing aqueous solution may be 0.2 μg / kg to 4000 μg / kg, 0.3 μg / kg to 3000 μg / kg, 0.5 μg / kg to 2000 μg / kg, 0.5 μg / kg to 1000 μg / kg, 0.5 μg / kg to 500 μg / kg, 0.5 μg / kg to 100 μg / kg, or 0.5 μg / kg to 10 μg / kg.
[0024] In some specific embodiments, the selenium-containing aqueous solution comprises the selenium compound, the selenium-containing composition, or a combination thereof.
[0025] In some specific embodiments, the contents are health foods. In some specific embodiments, the health foods do not contain elemental selenium or selenium compounds. In some specific embodiments, the contents do not contain elemental selenium or selenium compounds.
[0026] In some specific embodiments, the contents may include probiotics, plant extracts, and / or excipients. In some specific embodiments, the probiotics may be in the form of a dried bacterial powder. In some specific embodiments, the plant extracts may be in the form of a freeze-dried powder.
[0027] In some specific embodiments, the content is a first composition comprising maltodextrin, red yeast rice powder, crystalline cellulose, talc powder, magnesium stearate, and silica. In some specific embodiments, the first composition is used for "regulating blood lipids".
[0028] In some specific embodiments, the contents are a second composition comprising maltodextrin, isomaltooligosaccharides, inulin, digestion-resistant maltodextrin, a heat-sterilized Lactobacillus plantarum composition (comprising Lactobacillus plantarum L-137, dextrin and heat-sterilized Lactobacillus plantarum powder), and magnesium stearate. In some specific embodiments, the second composition is used for "improving gastrointestinal function".
[0029] In some specific embodiments, the contents are a third composition comprising Antrodia camphorata powder, a freeze-dried powder of the whole fermentation liquid of Antrodia camphorata mycelium, and magnesium stearate. In some specific embodiments, the third composition is used for "liver protection".
[0030] In some specific embodiments, the contents are a fourth composition comprising maltodextrin, glucose, freeze-dried Lactobacillus paracasei 33 powder, freeze-dried Lactobacillus fermentum powder, fructooligosaccharides, freeze-dried Lactobacillus acidophilus powder, magnesium stearate, and powdered flavors (including dextrin, gum arabic, flavors, propylene glycol, microcrystalline cellulose, mixed tocopherol concentrate, and lecithin). The edible oils include refined palm oil, soybean oil, cottonseed oil, and / or peanut oil. In some specific embodiments, the fourth composition is used for "immunomodulation".
[0031] In some specific embodiments, the content is a fifth composition comprising kefir fermented milk powder, calcium citrate, microcrystalline α-cellulose, cross-linked sodium carboxymethylcellulose, silica, magnesium stearate, and polyvinylpyrrolidone. In some specific embodiments, the fifth composition is used for "bone care".
[0032] In some specific embodiments, the content is a sixth composition comprising microcrystalline α-cellulose, Lactobacillus plantarum GKM3, magnesium stearate, and silica. In some specific embodiments, the sixth composition is used for "inhibiting the formation of body fat."
[0033] In some specific embodiments, the content is a seventh composition comprising microcrystalline α-cellulose, lactose, cross-linked sodium carboxymethylcellulose, gum arabic, magnesium stearate, maltodextrin, hydroxypropylmethylcellulose, silica, talc powder, polyethylene glycol, food yellow No. 4, vitamin E (antioxidant), and xanthan gum. In some specific embodiments, the seventh composition is used for "anti-fatigue".
[0034] In some specific embodiments, the content is an eighth composition comprising a lactic acid bacteria powder composition (Lactobacillus rhamnosus MP108, maltodextrin), maltodextrin, and magnesium stearate. In some specific embodiments, the eighth composition is used for "assisting in adjusting allergy predisposition".
[0035] In some specific embodiments, the content is a ninth composition comprising Lactobacillus reuteri, maltodextrin, and magnesium stearate. In some specific embodiments, the ninth composition is used for "blood sugar regulation".
[0036] In some specific embodiments, the contents are a tenth composition comprising Cistanche tubulosa extract, potato starch, and magnesium stearate, wherein the Cistanche tubulosa extract comprises phenylethanoid glycosides of Cistanche tubulosa. In some specific embodiments, the tenth composition is used for "aging retardation".
[0037] In some specific embodiments, the contents are an eleventh composition comprising sorbitol (sweetener), xylitol (sweetener), a peppermint flavor composition (including lactose, silica, and peppermint flavor), maltodextrin, magnesium stearate, freeze-dried Lactobacillus paracasei powder, and acesulfame potassium (sweetener). In some specific embodiments, the eleventh composition is used for "dental care".
[0038] In some specific embodiments, the content is a twelfth composition comprising Ferrochel. In some specific embodiments, the twelfth composition is used to "promote iron absorption."
[0039] In some specific embodiments, the contents are a thirteenth composition comprising maltodextrin, red yeast rice extract, and a red yeast rice powder composition (comprising yam powder and red yeast rice mold (Monascus purpureus NTU568)). In some specific embodiments, the thirteenth composition is used for "assisting in regulating blood pressure". [Brief description of the drawings]
[0040] [Figure 1] FIG. 1 is a schematic diagram of one example of a selenium-containing capsule structure according to the present invention. [Diagram 2] FIG. 2 is a schematic diagram of another example of a selenium-containing capsule structure according to the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0041] The objectives, advantages and technical features of the present invention will become more apparent from the following detailed description of the implementation and the accompanying drawings.
[0042] A schematic diagram of one example of the selenium-containing capsule structure according to the present invention is shown in Figure 1. The selenium-containing capsule structure 1 includes a shell 10 and a storage space 20, the shell 10 includes a selenium compound, a selenium-containing composition, or a combination thereof, and the storage space 20 is located inside the shell 10. The shell 10 includes a first capsule shell 11 and a second capsule shell 12, and the first capsule shell 11 and the second capsule shell 12 are fitted together to form the storage space 20. The storage space 20 is filled with a content 30, and the content 30 is a powder.
[0043] Another example of the selenium-containing capsule structure according to the present invention is shown in Fig. 2. The selenium-containing capsule structure 1 includes a shell 10 containing a selenium compound, a selenium-containing composition, or a combination thereof, and a containing space 20 located inside the shell 10. The containing space 20 is filled with a content 30, and the content 30 is liquid.
[0044] The preparation of the selenium-containing capsule structure according to the present invention will now be described.
[0045] Preparation of aqueous solutions of selenium-rich Spirulina water extract
[0046] Spirulina is cultivated in an aqueous solution containing nanoselenium with a selenium concentration of 876 mg / kg (a composition consisting of selenium nanoparticles and a dispersant, the particle size of the selenium nanoparticles is 30 nm to 250 nm, and the selenium concentration is 100 ppm to 1000 ppm) to obtain selenium-rich spirulina.
[0047] A fixed amount of selenium-rich spirulina is taken, processed in a grinder, and sieved through a sieve of 100 mesh to 200 mesh size to obtain selenium-rich spirulina fragments. Secondary water is then added in an amount twice the weight of the selenium-rich spirulina fragments, and stirred at room temperature for 1 hour to obtain an aqueous solution of the water extract of the selenium-rich spirulina containing selenocysteine.
[0048] Example 1
[0049] 20 g of gelatin and 100 g of modified corn starch are uniformly mixed at room temperature (25°C), and then 240 g of sorbose, 195 g of the aqueous solution of the selenium-rich spirulina water extract (containing selenocysteine), and 5 g of titanium dioxide are added and mixed uniformly. The mixture is heated to 80°C and mixed uniformly. The mixture is then placed in a fully automatic hollow capsule manufacturing machine (with automatic stirring and heating functions) and mixed uniformly again at 80°C until the mixture is completely dissolved and smooth, thereby producing a selenium-containing capsule structure comprising a first capsule shell and a second capsule shell.
[0050] Using an electrospray low-resolution mass spectrometer (model number 5500 manufactured by AB Sciex Corporation), the selenium-containing capsule structure was subjected to liquid chromatography (LC)-electrospray ionization (ESI)-triple quadrupole mass spectrometry (QQQ MS) measurement, which revealed that the selenium content in the selenium-containing capsule structure was 3.496 mg / kg (including inorganic selenium and organic selenium, with selenocysteine being 6.670 μg / kg).
[0051] Example 2
[0052] 1 g of gellan gum, 0.8 g of chitosan, and 0.2 g of potassium chloride are added to 20 g of the selenium-rich spirulina water extract aqueous solution (containing selenocysteine), mixed uniformly, heated to 80°C and mixed uniformly, and 78 g of hydroxypropyl methylcellulose is added and mixed uniformly. The mixture is then added to a fully automatic hollow capsule manufacturing machine (with automatic stirring and heating functions) and mixed uniformly again at 80°C until the mixture is completely dissolved and smooth, thereby producing a selenium-containing capsule structure comprising a first capsule shell and a second capsule shell.
[0053] LC-ESI-QQQ measurement of the selenium-containing capsule structure revealed that the selenium content in the selenium-containing capsule structure was 1.315 mg / kg (including inorganic selenium and organic selenium, and selenocysteine was 0.742 μg / kg).
[0054] As can be seen from Examples 1 and 2, by using an aqueous solution of selenium-rich spirulina water extract instead of water in the present invention, the selenium content of the obtained capsule structure can be made 0.1 mg / kg to 5000 mg / kg.
[0055] The capsule structure of the present invention, which contains selenocysteine derived from spirulina, has excellent human absorption rate, and the selenium content in the capsule structure can be accurately quantified by adjusting the concentration of selenium-rich water extract of spirulina. Since selenocysteine is derived from water extract of spirulina, it can be taken by vegetarians and does not cause problems such as loss of appetite, burning sensation in the stomach, stomach pain, nausea, vomiting, abdominal pain, diarrhea, etc. For people who need to supplement various nutrients at the same time, the capsule structure of the present invention can reduce the number of pills to be taken at one time, making it more convenient to supplement selenium element. [Explanation of symbols]
[0056] 1: Capsule structure 10:Shell 11: First capsule shell 12: Second capsule shell 20: Containment Space 30:Contents
Claims
1. a shell comprising a selenium compound, a selenium-containing composition, or a combination thereof; and a storage space located inside the shell. Selenium-containing capsule structure.
2. The selenium compound is selected from the group consisting of sodium selenate, sodium selenite, selenium dioxide, selenium citrate, selenium amino acids, small molecule selenoproteins, selenium polysaccharides, and combinations thereof, and the selenium concentration in the shell is 0.1 mg / kg to 5000 mg / kg. The selenium-containing capsule structure of claim 1.
3. The selenium-containing composition is a selenium-containing nutrient, the selenium-containing nutrient comprising selenium yeast, plant selenium, nanoselenium, blue-green algae extract or a combination thereof, and the selenium concentration in the shell is 0.1 mg / kg to 5000 mg / kg. The selenium-containing capsule structure of claim 1.
4. The cyanobacteria extract is a water extract of selenium-rich spirulina, and the selenium-rich spirulina is obtained by culturing the spirulina for 12 to 72 hours in an aqueous solution containing nanoselenium at a concentration of 500 mg / kg to 1000 mg / kg. The selenium-containing capsule structure according to claim 3.
5. The storage space is filled with a content, and the content is a powder or a liquid. The selenium-containing capsule structure of claim 1.
6. The capsule structure is a soft capsule structure and the shell is a sealed shell. The selenium-containing capsule structure of claim 1.
7. The capsule structure is a hard capsule structure, and the shell is composed of a first capsule shell and a second capsule shell, and the first capsule shell and the second capsule shell are fitted together to form the storage space. The selenium-containing capsule structure of claim 1.
8. The shell is prepared from a first blend solution, the first blend solution comprising 1% to 20% by weight of gelatin, 8% to 60% by weight of a swelling agent, 8% to 40% by weight of a plasticizer, 15% to 75% by weight of a selenium-containing aqueous solution, and 1% to 2% by weight of titanium dioxide, the selenium concentration in the selenium-containing aqueous solution being 0.1 mg / kg to 5000 mg / kg. The selenium-containing capsule structure according to claim 6.
9. The shell is prepared from a second blended solution, the second blended solution including 0.1% to 18% by weight of a hydrophilic gel, 62% to 96% by weight of a binder, 0.1% to 5% by weight of a plasticizer, 0.01% to 5% by weight of a flocculating aid, and 3% to 10% by weight of a selenium-containing aqueous solution, the selenium concentration of which is 0.1 mg / kg to 5000 mg / kg. The selenium-containing capsule structure according to claim 6.
10. The selenium-containing aqueous solution contains the selenium compound, the selenium-containing composition, or a combination thereof. The selenium-containing capsule structure according to claim 8 or 9.