Light irradiating device and light guide member holder

Abstract

A light emission device (100) is provided with: a holding unit 31 in an arm form that has one end 31a for holding an emission end 22 of a cable-shaped optical guidance member 20, and the other end 31b, and is provided such that the position and the angle of the one end 31a are adjustable; and a base unit 32 that is provided so as to be attachable to a structure 110, and supports the other end 31b of the holding unit 31.

Description

[Technical field]

[0001] The present invention relates to a light irradiation device and a light guide member holder. [Background technology]

[0002] Conventionally, a light irradiation device used in a treatment method for performing treatment by irradiating a treatment target site of a subject to which a drug containing a photosensitizer has been administered with therapeutic light is known. Such a light irradiation device is disclosed, for example, in JP2020-522745A.

[0003] The above-mentioned JP2020-522745A discloses a medical device including a light source for generating laser radiation and an optical fiber. The medical device is used for photodynamic therapy (PDT). Laser radiation is guided to a treatment area through the fiber. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Special Publication No. 2020-522745 Summary of the Invention [Problem to be solved by the invention]

[0005] Although not disclosed in the above-mentioned JP2020-522745A, the treatment of irradiating the treatment target area with laser light was performed by the doctor manually controlling the position and orientation of the tip of the optical fiber by holding the tip of the optical fiber with his / her hand.

[0006] In a treatment method in which a treatment light is irradiated to a treatment target area, it is important to precisely control the irradiation range of the treatment light on the treatment target area, the irradiation intensity per unit area of ​​the treatment light, etc., in order to obtain a desired treatment effect. The irradiation intensity per unit area depends on the distance between the emission end of the optical fiber and the treatment target area. When holding a light-guiding member such as an optical fiber by hand, there is a problem that it is difficult to precisely maintain the position and orientation of the emission end due to fatigue caused by the task of continuously holding the light-guiding member in the same position for a preset irradiation time, and due to the shaking of the hand position while holding it. However, a light-guiding member such as an optical fiber is flexible and easily bent, so it is not easy to fix it in a desired position and orientation.

[0007] The present invention has been made to solve the above-mentioned problems, and one object of the present invention is to provide a light irradiation device and a light-guiding member holder that are capable of precisely maintaining the position and orientation of the exit end of a light-guiding member in a treatment technique in which therapeutic light is irradiated to a treatment target area. [Means for solving the problem]

[0008] In order to achieve the above object, a light irradiation device according to a first aspect of the present invention is a light irradiation device for irradiating therapeutic light to a treatment target site of a subject to which a drug containing a photosensitizer has been administered, the light irradiation device comprising: a light source unit that generates therapeutic light; a cable-shaped light guiding member that includes an incident end connected to the light source unit and an exit end for emitting the light that has entered the incident end; an arm-shaped holding unit that has one end for holding the exit end of the light guiding member and another end opposite the one end, the one end being adjustable in position and angle; and a base unit that is attachable to a structure and supports the other end of the holding unit. The one end has a rod-like shape, and the holding portion has a guide portion that guides the light guide member along the direction in which the one end extends. do. A light irradiation device according to a second aspect of the present invention is a light irradiation device for irradiating therapeutic light to a treatment target site of a subject to which a drug containing a photosensitive substance has been administered, and includes a light source unit that generates therapeutic light, a cable-shaped light-guiding member including an incident end connected to the light source unit and an exit end for emitting light incident on the incident end, an arm-shaped holding unit having one end that holds the exit end of the light-guiding member and the other end opposite the one end, the one end being adjustable in position and angle, and a base unit that is attachable to a structure and supports the other end of the holding unit, and the base unit includes a contact surface that can come into contact with the structure, and an operation unit that switches between a fixed state in which the contact surface is fixed to the structure by pressing the contact surface against the structure and a release state in which the pressure is released.

[0009] The first aspect of this invention 3The light-guiding member holder according to the third aspect is a light-guiding member holder for holding a cable-shaped light-guiding member including an emission end for irradiating a therapeutic light to a treatment target site of a subject to which a drug containing a photosensitizer has been administered, the light-guiding member holder comprising: an arm-shaped holding section having one end for holding the emission end of the light-guiding member and another end opposite to the one end, the arm-shaped holding section being provided such that the position and angle of the one end can be adjusted; and a base section being provided so as to be attachable to a structure and supporting the other end of the holding section. The one end has a rod-like shape, and the holding portion has a guide portion that guides the light guide member along the direction in which the one end extends. do. A light-guiding member holder according to a fourth aspect of the present invention is a light-guiding member holder that holds a cable-shaped light-guiding member including an emitting end for irradiating therapeutic light to a target site of a subject that has been administered a drug containing a photosensitive substance, and is equipped with: an arm-shaped holding section having one end that holds the emitting end of the light-guiding member and another end opposite the one end, the one end being adjustable in position and angle; and a base section that is attachable to a structure and supports the other end of the holding section, and the base section includes a contact surface that can come into contact with the structure, and an operation section that switches between a fixed state in which the contact surface is fixed to the structure by pressing the contact surface against the structure and a release state in which the pressure is released. Effect of the Invention

[0010] According to the present invention, as described above, an arm-shaped holding section having one end portion for holding the exit end of the light-guiding member and the other end portion opposite to the one end portion, the position and angle of the one end portion being adjustable, and a base portion attached to a structure and supporting the other end portion of the holding section are provided. In this way, the base portion can be fixed to a structure present around the subject during treatment, and the exit end of the light-guiding member can be held by the arm-shaped holding section extending from the base portion. Then, by adjusting the position and angle of the one end portion that holds the exit end in the arm-shaped holding section, the position and orientation of the exit end of the light-guiding member can be adjusted. As a result, in a treatment method in which therapeutic light is irradiated to a treatment target site, the position and orientation of the exit end of the light-guiding member can be maintained with high accuracy. Note that by adjusting the position and orientation of the exit end, the irradiation range of the therapeutic light with respect to the treatment target site and the distance between the treatment target site and the exit end (i.e., the irradiation intensity per unit area of ​​the therapeutic light) can be controlled. As a result, the treatment accuracy can be improved to obtain a desired treatment effect. [Brief description of the drawings]

[0011] [Figure 1] FIG. 2 is a schematic diagram of a light irradiation device according to an embodiment. [Diagram 2] FIG. 2 is a schematic diagram showing a light guide member. [Diagram 3] FIG. 13 is a perspective view showing a configuration example of a light guide member holder. [Figure 4]FIG. 2 is an enlarged perspective view of an example of the configuration of a joint mechanism. [Diagram 5] 13 is a schematic perspective view of one end of a holding portion for explaining a guide portion. FIG. [Figure 6] FIG. 4 is a perspective view showing a state in which a light guide member is held at one end portion. [Figure 7] 4 is a schematic cross-sectional view for explaining the structure of the base portion shown in FIG. 3. [Figure 8] 4 is a perspective view showing a state in which the base portion shown in FIG. 3 is attached to a structure. FIG. [Figure 9] FIG. 13 is a schematic perspective view showing a light guide member holder according to a first modified example. [Figure 10] 10 is a schematic cross-sectional view for explaining the structure of the base portion shown in FIG. 9. [Figure 11] 13 is a perspective view showing a state in which a light-guiding member is held by a light-guiding member holder according to a first modified example. FIG. [Figure 12] FIG. 13 is a schematic perspective view showing a modified example of the guide portion. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0012] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings.

[0013] The configuration of a light irradiation device 100 according to one embodiment will be described with reference to FIGS.

[0014] 1 is a light irradiation device for irradiating a treatment target site 101a of a subject to which a drug 102 containing a photosensitizer has been administered with therapeutic light 80. In this embodiment, the light irradiation device 100 used in photoimmunotherapy will be described.

[0015] Photoimmunotherapy is a treatment technique in which a cancer patient is administered a drug containing a fluorescent substance that causes a photochemical reaction and an antibody that selectively binds to cancer cells, and the cancer cells are then irradiated with therapeutic light of a specific wavelength range corresponding to the fluorescent substance, causing a photochemical reaction and destroying the cancer cells.

[0016] In photoimmunotherapy, a drug 102 is administered into the body of a cancer patient 101 before treatment. The drug 102 includes a conjugate of a fluorescent substance that emits fluorescence and an antibody. The cancer patient 101 is an example of a "subject" in the claims. The cancer patient 101 may also be an animal other than a human.

[0017] A fluorescent substance is a substance that undergoes a photochemical reaction when continuously irradiated with light of a specific wavelength band. In photoimmunotherapy (a treatment for killing cancer cells by irradiating a drug 102 containing a fluorescent substance with light of a specific wavelength band), a light irradiation device 100 irradiates a treatment target site 101a of a cancer patient 101 with therapeutic light 80 of a specific wavelength band according to the type of fluorescent substance. The treatment target site 101a may be, for example, the head and neck, chest, abdomen, back, or internal organs (e.g., digestive tract, liver, adrenal gland, etc.), but is not limited thereto.

[0018] The fluorescent substance is a substance that is excited and emits fluorescence when irradiated with the therapeutic light 80. The fluorescent substance is, for example, a chemical substance such as IRDye (registered trademark) 700DX (hereinafter referred to as "IR700"). IR700 is excited by light with a wavelength of 600 nm or more and 700 nm or less, and emits light with a wavelength of about 700 nm or 770 nm as fluorescence.

[0019] The therapeutic light 80 is light in a wavelength range that causes a photochemical reaction of the fluorescent substance in the therapeutic drug 102. The wavelength varies depending on the type of fluorescent substance in the therapeutic drug 102. When IR700 is used as the fluorescent substance, the therapeutic light 80 is light with a wavelength of 600 nm or more and 700 nm or less, for example, non-thermal red light (near-infrared light) with a wavelength of about 690 nm.

[0020] The antibody contained in the drug 102 selectively binds to an antigen of a cancer cell (a specific protein expressed in a cancer cell). Therefore, the antibody is selected according to the antigen of the cancer cell to be treated. The antibody is, for example, cetuximab.

[0021] The drug 102 administered to the cancer patient 101 selectively binds to the antigens of the cancer cells present in the treatment target area 101a by the antibody while circulating in the body of the cancer patient 101 through the bloodstream. The fluorescent substance of the drug 102 absorbs the therapeutic light 80 irradiated to the treatment target area 101a, causing a photochemical reaction and changing the chemical structure of the fluorescent substance. This change in the chemical structure of the fluorescent substance causes a change in the three-dimensional structure of the antibody. The change in the three-dimensional structure of the antibody bound to the cancer cell damages the cell membrane of the bound cancer cell. As a result, the cancer cell expands and bursts due to water entering through the damaged part of the cell membrane of the cancer cell, and the cancer cell is destroyed (dead). Note that the fluorescent substance no longer emits fluorescence after the change in chemical structure due to the photochemical reaction.

[0022] In this embodiment, near infrared photoimmunotherapy (NIR-PIT) is described in particular in which a drug 102 using IR700, which is sensitive to near infrared light, is used as a fluorescent substance, and near infrared light is used as therapeutic light 80; however, photoimmunotherapy is not limited to this.

[0023] (Configuration of the light irradiation device) As shown in Fig. 1, the light irradiation device 100 is configured to output therapeutic light 80 in a specific wavelength band corresponding to a fluorescent substance contained in a drug 102 used in photoimmunotherapy. The light irradiation device 100 includes a light source unit 10, a light-guiding member 20, and a light-guiding member holder 30. The light-guiding member holder 30 includes a holder 31 that holds the emission end 22 of the light-guiding member 20, and a base unit 32 that supports the holder 31. The light irradiation device 100 further includes a control unit 15 and an input operation unit 16.

[0024] The light source unit 10 generates therapeutic light 80. The light source unit 10 outputs the generated therapeutic light 80 to the light-guiding member 20.

[0025] The light source section 10 includes at least one light source unit 11. Each light source unit 11 has one light output port 12. Thus, the light source section 10 includes at least one light output port 12 to which the light-guiding member 20 is connected. The light source section 10 is configured to be able to emit therapeutic light 80 from the light output port 12. In the example of FIG. 1, the light source section 10 includes four light source units 11. Thus, the light source section 10 includes four light output ports 12.

[0026] The therapeutic light 80 is light of a predetermined wavelength included in the absorption wavelength band of a fluorescent substance contained in a drug 102 administered to the body of a cancer patient 101 .

[0027] The light output port 12 is an exit port for the therapeutic light 80 and a connection port for the light-guiding member 20. One light output port 12 is connected to one light-guiding member 20. The number of light output ports 12 may be one or more. Each of the multiple light output ports 12 is configured to emit the therapeutic light 80 to the incident end 21 of the light-guiding member 20 connected to that light output port 12.

[0028] Each light source unit 11 includes a light source 13 that generates therapeutic light 80. The multiple (four) light source units 11 can emit therapeutic light 80 independently of each other. In this manner, the light source section 10 can individually switch between starting and stopping emission of the therapeutic light 80 from each of the multiple light output ports 12.

[0029] The light guiding member 20 has a function of guiding light emitted from the light output port 12 to the treatment target site 101a by being connected to any one of the light output ports 12 of the light source unit 10. The light guiding members 20 are cable-like members connected to the light output ports 12 one by one. The light guiding members 20 are disposable consumables. The maximum number of light guiding members 20 that can be simultaneously connected to the light source unit 10 is the number of light output ports 12. The number of light output ports 12 used simultaneously (i.e., the number of light guiding members 20) is determined according to the treatment content. For convenience, only one light guiding member 20 is shown in FIG. 1.

[0030] The light guide member 20 includes an incident end 21 connected to the light source unit 10, and an exit end 22 that emits light incident on the incident end 21. The incident end 21 and the exit end 22 are connected by an optical fiber cable 23. The incident end 21 includes an attachment for connection to the light output port 12. The exit end 22 is configured of a light diffusing member (light diffuser). As shown in FIG. 2, the exit end 22 is a forward-emitting light diffuser that emits light in a cone beam shape (or polygonal pyramid shape) by diffusing light at a predetermined irradiation angle toward the forward direction perpendicular to the end face of the exit end 22.

[0031] As shown in FIG. 1, the forward emission type light guide member 20 is used to irradiate therapeutic light 80 from outside the body of a cancer patient 101 toward the body surface. In photoimmunotherapy, in order to obtain a desired therapeutic effect, it is important to precisely control the irradiation range of the therapeutic light 80 on the treatment target site 101a (hatched area in FIG. 1), the irradiation intensity per unit area of ​​the therapeutic light 80, and the like. The irradiation range of the therapeutic light 80 irradiated from the emission end 22 to the treatment target site 101a depends on the distance between the emission end 22 and the treatment target site 101a and the angle of the optical axis of the emission end 22 with respect to the treatment target site 101a (i.e., the direction of the emission end 22). The irradiation intensity per unit area on the treatment target site 101a depends on the emission intensity of the therapeutic light 80 from the emission end 22 and the distance between the emission end 22 and the treatment target site 101a.

[0032] Therefore, it is important to accurately set the position and orientation of the emitting end 22 with respect to the treatment target area 101a and to continuously maintain the position and orientation of the emitting end 22 during treatment (while the therapeutic light 80 is being outputted). In this embodiment, the position and orientation of the emitting end 22 are adjusted and maintained by the light-guiding member holder 30.

[0033] 1, the controller 15 is a computer configured to control the light source unit 10. During photoimmunotherapy, the controller 15 controls the light source unit 10 to emit therapeutic light 80 from the emission end 22 of the light-guiding member 20. The controller 15 controls the light source units 11 individually, thereby individually controlling the start and end of irradiation of therapeutic light 80 (switching ON / OFF of irradiation of therapeutic light 80) for each of the optical output ports 12.

[0034] The control unit 15 is configured by a computer including a processor and a storage unit. The processor is configured by, for example, a CPU (Central Processing Unit) or the like. The storage unit includes, for example, a volatile memory and a non-volatile memory such as a flash memory or a hard disk drive. The storage unit stores a program for causing the processor to function as the control unit 15 of the light irradiation device 100, and various setting information for performing light irradiation.

[0035] The input operation unit 16 is connected to the controller 15 and configured to receive an input for starting or stopping irradiation of the therapeutic light 80. The input operation unit 16 is configured by an input device such as a foot switch or a hand switch. The controller 15 outputs the therapeutic light 80 from the light output port 12 in response to the input received via the input operation unit 16.

[0036] The number of light output ports 12 used in photoimmunotherapy is preset in the controller 15 by a doctor or the like depending on the type of treatment for the cancer patient 101. Specifically, the irradiation conditions of the therapeutic light 80 are preset as setting information in the controller 15. The irradiation conditions of the therapeutic light 80 may include setting information such as the irradiation time of the therapeutic light 80, the total energy amount of the therapeutic light 80, and the output intensity of the therapeutic light 80. The total energy amount is the total energy of the therapeutic light 80 when the therapeutic light 80 with the set output intensity is irradiated onto the treatment target site 101a for the set treatment time, and is expressed as the amount of energy per unit area (J / cm). In photoimmunotherapy, the therapeutic effect is controlled by setting the amount of energy per unit area of ​​the treatment target site 101a to a desired value.

[0037] The light-guiding member holder 30 is a holder for holding a cable-shaped light-guiding member 20 including an emission end 22 for irradiating therapeutic light 80 to a treatment target area 101a of a subject (cancer patient 101) to which a drug 102 containing a photosensitive substance has been administered.

[0038] The light-guiding member holder 30 includes an arm-shaped holder 31 having one end 31a for holding the emission end 22 of the light-guiding member 20 and the other end 31b opposite to the one end 31a. The holder 31 is provided such that the position and angle of the one end 31a can be adjusted. The holder 31 preferably includes a joint mechanism 40 between the one end 31a and the other end 31b, and the position and angle of the one end 31a can be adjusted by the joint mechanism 40. One or more holders 31 may be provided.

[0039] The light-guiding member holder 30 includes a base portion 32 that supports the other end portion 31b of the holder 31. The base portion 32 is provided so as to be attachable to the structure 110. The base portion 32 is configured to support one or a plurality of holders 31.

[0040] The structure 110 is not particularly limited as long as it is a structure present at a treatment site where the cancer patient 101 is treated. The structure 110 may be, for example, a member for supporting various instruments used in treatment, such as a support bar or a mounting table attached to a bed 120 on which the cancer patient 101 is placed. The structure 110 may be a stand member for attaching an IV bag. The structure 110 may be a support member for an apparatus used in treatment together with the light irradiation device 100. The apparatus used in treatment together with the light irradiation device 100 is, for example, a fluorescence imaging device 200 (see FIG. 11 ), which will be described later. The base unit 32 may use a support mechanism 210 (see FIG. 11 ) for supporting the fluorescence imaging device 200 as the structure 110.

[0041] (Light guide member holder) Next, a detailed configuration of the light guide member holder 30 will be described. Fig. 3 shows an example of a configuration in which a plurality of (two) holders 31 are individually attached to one base portion 32.

[0042] (holding part) As shown in Fig. 3, the holder 31 includes a plurality of joint mechanisms 40 connected in series between one end 31a and the other end 31b. In the example of Fig. 3, one holder 31 includes three joint mechanisms 40. The three joint mechanisms 40 have the same configuration. When distinguishing between the three joint mechanisms 40, they are referred to as joint mechanisms 40a, 40b, and 40c in order from the other end 31b side to the one end 31a side.

[0043] Each joint mechanism 40 includes a rod-shaped link 41 and a joint 42 that rotatably holds the link 41. The link 41 is a rod-shaped member that extends linearly with a predetermined length. As shown in FIG. 4, a connection part 41a with the joint 42 is formed at each end of the link 41. The connection part 41a has a shape that matches the structure of the joint 42. The link 41 has sufficient rigidity not to bend under normal use conditions. Each part (link 41, joint 42, etc.) that constitutes the joint mechanism 40 is preferably made of a metal material that can be sterilized. Examples of the metal material that can be sterilized include stainless steel and aluminum (or aluminum alloy).

[0044] The joint 42 connects one link 41 on the one end 31a side and the other link 41 on the other end 31b side so that they can rotate with each other. Therefore, the joint 42 has a pair of receiving parts that rotatably hold the connection parts 41a of the links 41. The joint 42 is configured so that the rotation angle of the link 41 can be adjusted by an external force applied by the user, and the adjusted angle of the link 41 can be maintained. In other words, the torque required to rotate the link 41 is greater than the torque that naturally acts on the joint 42 due to the action of gravity.

[0045] As shown in Fig. 4, the joint 42 is configured by a spherical joint. In the example of Fig. 4, the joint 42 includes a pair of holding plates 43a, 43b and a fastening member 45 that fastens the pair of holding plates 43a, 43b.

[0046] Each of the pair of holding plates 43a, 43b has a recess 44 that receives a part of the connection portion 41a of the link 41. The recess 44 is a through hole that passes through the holding plate 43a or 43b in the thickness direction, but may be a non-through recess. Two recesses 44 are formed in each of the holding plates 43a, 43b, one at each end in the long side direction. The pair of holding plates 43a, 43b are arranged so that the two recesses 44 at both ends face each other.

[0047] One receiving portion is formed by a pair of recesses 44 facing each other at one end, and another receiving portion is formed by another pair of recesses 44 facing each other at the other end. The connecting portion 41a of the link 41 engages with the receiving portion formed by the pair of recesses 44.

[0048] Specifically, the connection portion 41a of the link 41 is disposed between a pair of holding plates 43a and 43b. The connection portion 41a has a spherical shape. A part of the spherical connection portion 41a is disposed in a recess 44 of the holding plate 43a, and another part of the connection portion 41a is disposed in a recess 44 of the holding plate 43b. As a result, the connection portion 41a of the link 41 is sandwiched between the pair of holding plates 43a and 43b in a state where it is fitted into a pair of recesses 44 of the pair of holding plates 43a and 43b, respectively. Thereby, the connection portion 41a is rotatably engaged with the pair of holding plates 43a and 43b in a pair of opposing recesses 44 (receiving portions). As a result, the joint 42 holds the connection portion 41a rotatably in any direction. Similarly, the connection portion 41a of the other link 41 is disposed in the other pair of recesses 44 (receiving portions) of the pair of holding plates 43a and 43b.

[0049] The joint 42 allows the link 41 (connection portion 41a) to rotate about the connection portion 41a in a direction along the surfaces of the pair of holding plates 43a, 43b. The joint 42 allows the link 41 to rotate about the connection portion 41a in a direction in which the pair of holding plates 43a, 43b face each other. The joint 42 allows the link 41 to rotate around the central axis of the link 41.

[0050] The fastening member 45 fastens the pair of holding plates 43a, 43b in a direction in which they approach each other. That is, the fastening member 45 presses each of the pair of holding plates 43a, 43b toward the connection portion 41a.

[0051] Specifically, the fastening member 45 includes a bolt 45a and a nut 45b. A through hole (not shown) for passing the shaft of the bolt 45a is formed in the center of each of the holding plates 43a, 43b (between the recess 44 at one end and the recess 44 at the other end).

[0052] The pair of holding plates 43a, 43b are joined to each other by a bolt 45a passing through a through hole of the holding plates 43a, 43b. The pair of holding plates 43a, 43b are connected to each other and fastened from both outside by the bolt 45a and nut 45b.

[0053] The magnitude of the torque required to rotate the connection portion 41a can be adjusted by adjusting the amount of fastening of the fastening member 45. After the link 41 is aligned by the fastening member 45 so that the link 41 faces a desired rotation angle, the link 41 is fixed to the joint 42 so that the link 41 does not rotate naturally.

[0054] Deformable Member As shown in FIG. 3, in this embodiment, the holding unit 31 has a deformable member 50 that can be bent and deformed by an external force and can maintain its shape. The deformable member 50 constitutes one end 31a of the holding unit 31. That is, the deformable member 50 is disposed on the holding unit 31 closest to the one end 31a side. In FIG. 3, the joint mechanism 40a (first set of joints 42 and links 41), the joint mechanism 40b (second set of joints 42 and links 41), the joint mechanism 40c (third set of joints 42 and links 41), and the deformable member 50 are disposed in this order from the other end 31b side (base unit 32 side) toward the one end 31a side. The deformable member 50 is connected to the end (connection portion 41a) of the link 41 of the joint mechanism 40c. The tip of the deformable member 50 is the one end 31a of the holding unit 31.

[0055] The deformable member 50 is a wire-like member. The deformable member 50 is made of metal. The metal constituting the deformable member 50 is, for example, stainless steel or aluminum (or an aluminum alloy). The deformable member 50 has a diameter (outer diameter) larger than, for example, the optical fiber cable 23 of the light-guiding member 20. The deformable member 50 can be bent into any shape by a user applying an external force by hand. The deformable member 50 maintains the bent shape due to the rigidity of the deformable member 50 itself. Unlike the link 41, the deformable member 50 can be bent freely, so that the user can freely adjust the position, orientation, and path leading to the one end 31a of the one end 31a.

[0056] <Guide section> As shown in Fig. 5, in this embodiment, the holder 31 has a guide portion 55 that guides the light guide member 20. As shown in Fig. 6, the guide portion 55 guides the light guide member 20 along the extending direction of the one end portion 31a. The extending direction of the one end portion 31a is the extending direction of the central axis line 31e of the rod-shaped one end portion 31a. The guide portion 55 guides the light guide member 20 so that the orientation of the exit end 22 of the light guide member 20 (the optical axis direction from the exit end 22) is along the extending direction of the one end portion 31a.

[0057] Returning to FIG. 5, the guide portion 55 is provided on one end 31a of the holding portion 31. The guide portion 55 is a groove or a protrusion (see FIG. 12) formed on the outer surface of the one end 31a. In the example of FIG. 5, the guide portion 55 is a groove. The one end 31a is made of a round bar-shaped tip member. A V-shaped groove constituting the guide portion 55 is formed on the outer surface of the one end 31a.

[0058] The guide portion 55 has guide surfaces 55a on which a part of the light guiding member 20 (see FIG. 6) can be disposed. That is, the outer peripheral surface of the light guiding member 20 contacts the guide surfaces 55a. The light guiding member 20 is oriented by the guide surfaces 55a. In the groove-shaped guide portion 55, the inner surface of the groove is the guide surfaces 55a. That is, the guide portion 55 has a pair of guide surfaces 55a formed in a V-shape.

[0059] 6, at one end 31a, the light guiding member 20 is disposed so as to be fitted inside a groove-shaped guide portion 55. The outer peripheral surface of the light guiding member 20 comes into contact with a pair of guide surfaces 55a, so that the light guiding member 20 is guided along the guide portion 55. In this state, the light guiding member 20 is fixed to the one end 31a.

[0060] 5 and 6, the holder 31 has a ring-shaped fixing member 56. The inner diameter of the fixing member 56 is the same as or slightly larger than the outer diameter of the rod-shaped one end 31a. The one end 31a, in which the light guiding member 20 is fitted into the guide portion 55, is disposed inside the fixing member 56, whereby the light guiding member 20 is held at the one end 31a. The fixing member 56 is made of an elastically deformable resin material such as silicone rubber. The fixing member 56 bundles the one end 31a and the light guiding member 20 together, and holds the light guiding member 20 while biasing it against the guide surface 55a.

[0061] 6, the direction of the one end 31a of the holding unit 31 (the central axis 31e of the one end 31a) coincides with the direction of the emitting end 22 of the light-guiding member 20. Therefore, by directing the one end 31a toward the treatment target area 101a, the therapeutic light 80 emitted from the emitting end 22 can be directed toward the treatment target area 101a with high accuracy.

[0062] <Number and type of holding parts> 3, a plurality of holding portions 31 may be provided on the base portion 32. In this embodiment, the holding portion 31 includes a first holding portion 31-1 having a first length L1 and a second holding portion 31-2 having a second length L2 greater than the first length L1. In this specification, the "first length" and "second length" refer to the entire length of the holding portion 31, and more specifically, the path length from the other end portion 31b to the one end portion 31a (the total length of each of the joint mechanisms 40a to 40c and the deformable member 50).

[0063] The first holding unit 31-1 and the second holding unit 31-2 have different lengths due to differences in at least one of the number of joint mechanisms 40 and the dimensions of the components. FIG. 3 shows an example in which the number of joint mechanisms 40 is the same in the first holding unit 31-1 and the second holding unit 31-2, but the dimensions of the link 41 of the first joint mechanism 40a are different. The length of the link 41 of the first set (joint mechanism 40a) of the second holding unit 31-2 is longer than the length of the link 41 of the first set (joint mechanism 40a) of the first holding unit 31-1. As a result, the second length L2 is longer than the first length L1.

[0064] As a method for varying the lengths of the holding parts 31, for example, the number of joint mechanisms 40 constituting the holding part 31 may be varied. For example, the lengths of the deformable members 50 constituting the holding part 31 may be varied. For example, the first holding part 31-1 may not be provided with a deformable member 50, while the second holding part 31-2 may be provided with a deformable member 50, thereby making the lengths of the holding parts 31 different. Note that a plurality of holding parts 31 of the same length may be provided.

[0065] In this embodiment, the joint 42 is composed of a pair of holding plates 43a, 43b (see FIG. 4) and a fastening member 45, so that the joint mechanism 40 is configured to be disassembled and assembled. Therefore, the holding unit 31 is configured to be able to change the number of joint mechanisms 40 by disassembling and assembling. In addition, the length of the holding unit 31 can be freely set by replacing a plurality of types of links 41 (see FIG. 3) having different lengths. By changing the number of joint mechanisms 40, the fastening force of the fastening member 45 in the joint 42 (the magnitude of the torque required to rotate the link 41) can be adjusted so that the link 41 does not rotate naturally due to gravity even if the weight acting on the joint 42 changes.

[0066] <Base section> 3, the base portion 32 includes a main body portion 32a that is detachable from the structure 110. In the example of FIG. 3, the base portion 32 can hold a plurality of holding portions 31. The base portion 32 is configured to detachably hold each of the holding portions 31. That is, the number of holding portions 31 corresponding to the number of light guiding members 20 to be used can be attached to the base portion 32, and the holding portions 31 that are not used can be removed from the base portion 32.

[0067] The base portion 32 includes a plurality of mounting portions 32b to which the holding portions 31 can be detachably attached. Each of the mounting portions 32b receives and supports one holding portion 31. Specifically, the mounting portions 32b are configured by screw holes formed in the main body portion 32a. FIG. 3 illustrates a situation in which four mounting portions 32b are formed in the main body portion 32a, and the holding portions 31 are attached to two of the mounting portions 32b.

[0068] As shown in FIG. 7, the other end 31b of the holding part 31 is configured with an attachment for attaching the holding part 31 to the base part 32. The other end 31b has a connection part 31c having the same shape as the connection part 41a of the link 41 of the holding part 31, and a threaded part (male thread) 31d attached to the attachment part 32b of the base part 32. The connection part 31c of the other end 31b is connected to the receiving part of the first set of joints 42. The threaded part 31d engages with the attachment part 32b, which is a screw hole (female thread). The holding part 31 is attached to the base part 32 by fastening the threaded part 31d to the attachment part 32b. The holding part 31 can be removed from the base part 32 by releasing the fastening between the threaded part 31d and the attachment part 32b.

[0069] Next, a structure for attaching the base portion 32 to the structure 110 will be described.

[0070] Fig. 7 shows an example of a main body 32a that can be attached to a columnar structure 110. Specifically, in the example of Fig. 7, the main body 32a is divided into two blocks 60a, 60b, and is configured so that the structure 110 is sandwiched between the two blocks 60a, 60b. The two blocks 60a, 60b are joined to each other by a bolt 61.

[0071] The base portion 32 has a contact surface 32c that can come into contact with the structure 110. That is, a concave contact surface 32c (recess) for inserting the structure 110 is formed on each of the joining surfaces (facing surfaces) of the two blocks 60a, 60b. A through hole 62 that penetrates the main body portion 32a is formed by each of the contact surfaces 32c of the blocks 60a, 60b. The columnar structure 110 is disposed so as to pass through the inside of this through hole 62.

[0072] In the example of FIG. 8, the structure 110 is a support bar attached to a bed 120 on which a cancer patient 101 is placed. The support bar includes a first portion 121 and a second portion 122. The first portion 121 rises upward from the lower portion of the bed 120, passes the side of the bed 120, and extends to a position above the bed 120. The second portion 122 extends horizontally from the upper end of the first portion 121 so as to cross above the bed 120. The main body portion 32a of the base portion 32 is attached to the second portion 122 of the support bar. The second portion 122 of the support bar, which is the structure 110, is inserted into the through hole 62 (see FIG. 7) of the main body portion 32a.

[0073] As shown in FIG. 7, the concave contact surface 32c of the block 60a and the concave contact surface 32c of the block 60b can each come into contact with the structure 110 (the second portion 122).

[0074] The base unit 32 also includes an operation unit 65 for performing a switching operation to fix or release the base unit 32 to the structure 110. The operation unit 65 switches the state of the base unit 32 between a fixed state in which the contact surface 32c is fixed to the structure 110 by pressing the contact surface 32c against the structure 110, and a released state in which the pressing is released.

[0075] The operation unit 65 includes a lever 66 and a pressing unit 67 that can advance and retreat toward the through-hole 62 in response to the operation of the lever 66. The lever 66 is rotatably provided on the main body 32a, and can be operated by a user by gripping it with his or her hand. The pressing unit 67 is, for example, a screw member disposed in a hole that penetrates from the outside of the main body 32a to the inside of the through-hole 62. The pressing unit 67 is connected to the lever 66, and is disposed with a tip facing toward the inside of the through-hole 62. The pressing unit 67 meshes with, for example, a screw groove (female screw) formed in the main body 32a, and advances and retreats toward the through-hole 62 by the rotation of the lever 66.

[0076] When the lever 66 is rotated in the forward direction, the pressing portion 67 advances toward the through-hole 62 and presses the structure 110 in the through-hole 62. As a result, the contact surface 32c of the main body portion 32a is pressed against the structure 110. This causes the base portion 32 to be fixed.

[0077] When the lever 66 is rotated in the opposite direction, the pressing portion 67 moves in a direction away from the through-hole 62, and releases the pressure on the structure 110 in the through-hole 62. As a result, the base portion 32 is released. Since the pressing force is no longer acting, the base portion 32 becomes movable relative to the structure 110.

[0078] The light guide member holder 30 of this embodiment is configured as described above.

[0079] (Treatment procedure using light irradiation device) Next, an example of the flow of treatment using the light irradiation device 100 will be described.

[0080] First, the light-guiding member holder 30 is prepared. Since the number of light-guiding members 20 to be used is determined according to the treatment plan, the same number of holders 31 as the number of light-guiding members 20 are attached to the base portion 32.

[0081] At this time, as shown in Fig. 8, the length of the holding part 31 to be attached to the base part 32 is determined in consideration of the attachment position of the base part 32 with respect to the structure 110, the relative position of the treatment target site 101a (see Fig. 1) of the patient 101, and the presence or absence of obstacles. The holding part 31 according to the determined length is attached to the base part 32. As the holding part 31 to be attached, for example, either the first holding part 31-1 or the second holding part 31-2 is selected. Furthermore, in this embodiment, since the holding part 31 can be disassembled and assembled, the holding part 31 with the length appropriately adjusted is attached to the base part 32.

[0082] When the required number of holding units 31 are attached to the base unit 32, the base unit 32 is attached to the structure 110. The user switches the base unit 32 from the open state to the fixed state by operating the operation unit 65. This causes the base unit 32 to be fixed to the structure 110. Note that the holding units 31 may be attached to the base unit 32 after the base unit 32 is fixed to the structure 110.

[0083] 6, the user holds the emission end 22 of the light guiding member 20 at one end 31a of the holding unit 31. The light guiding member 20 is guided by the guide unit 55, so that the orientation of the emission end 22 is aligned with the extension direction of the one end 31a.

[0084] 8, the light guiding member 20 is omitted, but the position and orientation of each one end 31a are set by adjusting the joint mechanism 40 and the deformable member 50 of each holding part 31. As a result, the emission end 22 of each light guiding member 20 held by each holding part 31 is accurately positioned at the planned irradiation position toward the treatment target site 101a. Each holding part 31 maintains the set position and orientation of one end 31a.

[0085] This completes preparations for irradiation of the therapeutic light 80. As shown in FIG. 1, the doctor operates the light irradiation device 100 by inputting information to the input operation unit 16. In response to a signal from the input operation unit 16, the control unit 15 controls the light source unit 10 to emit the therapeutic light 80. As a result, the therapeutic light 80 is emitted from the emission end 22 of each light-guiding member 20 held in each holding unit 31 to the treatment target site 101a. During treatment, the doctor does not need to hold the emission end 22 of the light-guiding member 20 by hand. When a preset irradiation time has elapsed, the irradiation of the therapeutic light 80 is stopped. This ends the irradiation of the therapeutic light 80.

[0086] (Effects of this embodiment) In this embodiment, the following effects can be obtained.

[0087] That is, the light irradiation device 100 of this embodiment is a light irradiation device 100 for irradiating therapeutic light 80 to a treatment target site 101a of a subject (cancer patient 101) to which a drug 102 containing a photosensitive substance has been administered, as described above, and includes a light source unit 10 that generates the therapeutic light 80, a cable-like light-guiding member 20 including an incident end 21 connected to the light source unit 10 and an exit end 22 that emits the light that has entered the incident end 21, an arm-like holding unit 31 having one end 31a that holds the exit end 22 of the light-guiding member 20 and the other end 31b opposite to the one end 31a, the position and angle of the one end 31a being adjustable, and a base unit 32 that is attachable to a structure 110 and supports the other end 31b of the holding unit 31.

[0088] Furthermore, the light-guiding member holder 30 of this embodiment is a light-guiding member holder 30 that holds a cable-like light-guiding member 20 including an emission end 22 for irradiating therapeutic light 80 to a treatment target site 101a of a subject (cancer patient 101) to which a drug 102 containing a photosensitive substance has been administered, and is equipped with an arm-like holding unit 31 having one end 31a that holds the emission end 22 of the light-guiding member 20 and the other end 31b opposite to the one end 31a, the position and angle of the one end 31a being adjustable, and a base unit 32 that is attachable to a structure 110 and supports the other end 31b of the holding unit 31.

[0089] With the above configuration, the base unit 32 is fixed to the structure 110 present around the subject (cancer patient 101) during treatment, and the arm-shaped holder 31 extending from the base unit 32 can hold the emission end 22 of the light-guiding member 20. The position and orientation of the emission end 22 of the light-guiding member 20 can be adjusted by adjusting the position and angle of the one end 31a of the arm-shaped holder 31 that holds the emission end 22. As a result, the position and orientation of the emission end 22 of the light-guiding member 20 can be maintained with high accuracy in a treatment method in which the therapeutic light 80 is irradiated to the treatment target site 101a. By adjusting the position and orientation of the emission end 22, the irradiation range of the therapeutic light 80 on the treatment target site 101a and the distance between the treatment target site 101a and the emission end 22 (i.e., the irradiation intensity per unit area of ​​the therapeutic light 80) can be controlled. As a result, the treatment accuracy can be improved to obtain a desired therapeutic effect.

[0090] In the above embodiment, further advantages can be obtained by configuring as follows.

[0091] Specifically, in this embodiment, the holder 31 includes a plurality of joint mechanisms 40 connected in series between the one end 31a and the other end 31b. With this configuration, the position and orientation of the one end 31a at which the emission end 22 of the light guide member 20 is held can be adjusted by each of the plurality of joint mechanisms 40. The greater the number of joint mechanisms 40, the greater the degree of freedom of the posture of the holder 31 from the other end 31b to the one end 31a. Therefore, by using the plurality of joint mechanisms 40 connected in series, even if there is an obstacle (such as a medical device) around the patient, the emission end 22 can be disposed in a desired position and orientation while avoiding the obstacle.

[0092] In this embodiment, the joint mechanism 40 includes a rod-shaped link 41 and a joint 42 that rotatably holds the link 41. With this configuration, each joint mechanism 40 of the holding unit 31 can be configured with a simple and lightweight structure.

[0093] In this embodiment, the joint 42 is configured as a spherical joint. With this configuration, there is no restriction on the rotation direction of the joint 42, so the link 41 can be rotated in any direction in each joint mechanism 40. Therefore, the degree of freedom of the posture of the holding part 31 from the other end 31b to the one end 31a can be effectively increased.

[0094] In this embodiment, the one end 31a has a rod-like shape, and the holder 31 has a guide portion 55 that guides the light-guiding member 20 along the extending direction of the one end 31a. With this configuration, the direction of the exit end 22 of the light-guiding member 20 can be aligned with the extending direction of the one end 31a of the holder 31 (the axial direction of the one end 31a). Therefore, even with a flexible cable-like light-guiding member 20, the exit direction of the therapeutic light 80 from the exit end 22 can be accurately adjusted.

[0095] In the present embodiment, guide portion 55 is a groove or a protrusion formed on the outer surface of one end portion 31a, and has guide surface 55a on which a part of light guide member 20 can be disposed. With this configuration, by bringing light guide member 20 into contact with guide surface 55a of guide portion 55, the orientation of emission end 22 can be easily and accurately aligned with the extension direction of one end portion 31a of holder 31.

[0096] In this embodiment, the holder 31 has a deformable member 50 that can be bent and deformed by an external force and can maintain its shape, and the deformable member 50 constitutes one end 31a of the holder 31. With this configuration, the position and orientation of the one end 31a can be adjusted arbitrarily by bending the deformable member 50. Since the light-guiding member 20 is an extremely lightweight cable-like member, by using a deformable member 50 having a rigidity sufficient to support the weight of the tip of the light-guiding member 20, the light-guiding member 20 can be held by the one end 31a of the tip of the deformable member 50 without changing the shape of the adjusted deformable member 50. This allows the position and orientation of the emission end 22 of the light-guiding member 20 to be adjusted extremely freely.

[0097] In the present embodiment, the light source unit 10 includes a plurality of light output ports 12 to which the light guide members 20 can be connected, and the base unit 32 includes a plurality of attachment units 32b to which the holders 31 can be attached and detached. In this configuration, in a configuration in which the therapeutic light 80 can be irradiated from each of the light guide members 20, a plurality of holders 31 can be attached to the base unit 32 according to the number of light guide members 20 to be used. When the number of light guide members 20 is reduced, the unused holders 31 can be removed from the base unit 32, so that the unused holders 31 do not interfere with the treatment. As a result, high convenience is achieved in that it is possible to accommodate a case in which the number of light guide members 20 used in treatment changes depending on the treatment content.

[0098] In the present embodiment, the holding part 31 includes a first holding part 31-1 having a first length L1 and a second holding part 31-2 having a second length L2 greater than the first length L1. With this configuration, the holding parts 31 having different lengths can be used depending on the distance from the base part 32 to the arrangement position of the emitting end 22 (the emitting position of the therapeutic light 80). For example, the first holding part 31-1 having a short length is used at the irradiation position closer to the base part 32, and the second holding part 31-2 having a long length is used at the irradiation position farther from the base part 32, thereby preventing the holding part 31 from unnecessarily occupying space due to the excess length. Therefore, the holding part 31 does not get in the way of the work of the medical practitioner. In addition, when there is an obstacle between the base part 32 and the arrangement position of the emitting end 22, the second holding part 31-2 having a long length can be used to hold the emitting end 22 at an appropriate position while bypassing the obstacle. These can improve the workability of the treatment.

[0099] Moreover, in this embodiment, the base unit 32 includes a contact surface 32c that can come into contact with the structure 110, and an operation unit 65 that switches between a fixed state in which the contact surface 32c is fixed to the structure 110 by pressing the contact surface 32c against the structure 110, and a release state in which the pressing is released. With this configuration, the operation unit 65 can easily fix and release the base unit 32 to the structure 110. As a result, it is possible to effectively improve the operability in the work of preparing for treatment and the work after the treatment is completed.

[0100] [Variations] The embodiments disclosed herein should be considered to be illustrative and not restrictive in all respects. The scope of the present invention is indicated by the claims, not by the description of the embodiments above, and further includes all modifications (variations) within the meaning and scope of the claims.

[0101] (First Modification) Fig. 9 shows a first modified example of this embodiment. The base part 132 according to the first modified example differs from the base part 32 (see Fig. 3) of the above embodiment in terms of its structure and the structure 110 to which it is attached. In the example of Fig. 9, the structure 110 to which the base part 132 is attached is a support mechanism 210 for supporting a fluorescence imaging device 200 (see Fig. 11). The support mechanism 210 has a beam-like structure with a rectangular cross section, and holds the fluorescence imaging device 200 movably.

[0102] In the example of Fig. 9, the base part 132 is configured to be attachable to and detachable from the structure 110 via the covering sheet 105. The covering sheet 105 is a sterilized medical drape. The base part 132 has a contact surface 32c (see Fig. 10) that can contact the structure 110 (support mechanism 210) via the covering sheet 105. The base part 132 includes a pressing member 134 that presses the contact surface 32c against the structure 110.

[0103] As shown in FIG. 10, the outer peripheral surface of the structure 110 having a rectangular cross section is covered with a covering sheet 105. The base portion 132 includes three flat plate portions 133a, 133b, and 133c along the upper surface and a pair of side surfaces of the structure 110. The inner surfaces of these flat plate portions 133a, 133b, and 133c are the contact surface 32c. The contact surface 32c faces the structure 110 (support mechanism 210) via the covering sheet 105. A pressing member 134 is provided at the lower end portions of the pair of flat plate portions 133a and 133c. The pressing member 134 biases the lower end portions of the pair of flat plate portions 133a and 133c in a direction in which they approach each other. In FIG. 10, the pressing member 134 is an expandable and contractible band-shaped member. The pressing member 134 may be a fastening member made of a bolt and a nut. The contact surface 32 c is pressed against the structure 110 via the cover sheet 105 by the biasing force of the pressing member 134 , and the base portion 132 is fixed to the structure 110 .

[0104] In the first modified example, the base portion 132 has a contact surface 32c that can contact the structure 110 via the covering sheet 105, so that the base portion 132 can be attached to a large structure that is difficult to sterilize or a structure that is fixedly installed indoors, etc.

[0105] As shown in Fig. 11, the fluorescence imaging device 200 is disposed so that the lens unit 201 faces the treatment target site 101a of the cancer patient 101. Note that Fig. 11 does not show the portion that supports the fluorescence imaging device 200 by the support mechanism 210. In photoimmunotherapy, a fluorescent substance (IR700) contained in the drug 102 is excited by the therapeutic light 80 and generates fluorescence with a wavelength different from that of the therapeutic light 80. The fluorescence imaging device 200 detects the fluorescence emitted from the treatment target site 101a and generates a fluorescence image. The progress of the treatment can be confirmed from the fluorescence image.

[0106] The fluorescence imaging device 200 and the light guiding member 20 are both disposed toward the treatment target site 101a, and therefore may become obstacles to each other. In this first modified example, a plurality of holding parts 31 (first holding part 31-1 and second holding part 31-2) having different lengths are provided on the base part 132, so that the holding parts 31 can circumvent the obstacle (fluorescence imaging device 200). That is, the first holding part 31-1 having a relatively short length holds the exit end 22 of the light guiding member 20 at an irradiation position closer to the base part 132. The second holding part 31-2 having a relatively long length holds the exit end 22 of the light guiding member 20 in a manner that circumvents the field of view of the fluorescence imaging device 200 to an irradiation position farther from the base part 132. As a result, the exit end 22 of the light guiding member 20 can be disposed at an appropriate irradiation position while preventing the holding parts 31 and the light guiding member 20 from being captured in the fluorescence image.

[0107] Although FIG. 10 shows an example in which the holding portion 31 is attached to the upper flat portion 133b of the base portion 132, as shown in FIG. 11, the holding portion 31 may be attached to the flat portion 133c on the side surface of the base portion 132.

[0108] (Other variations) In the above embodiment, the holding unit 31 includes a plurality of joint mechanisms 40 connected in series between the one end 31a and the other end 31b, but the present invention is not limited to this. In the present invention, the holding unit 31 does not need to include the joint mechanism 40. The entire holding unit 31 may be made of a bendable member. This also allows the one end 31a of the holding unit 31 to be adjusted to any position and angle. However, if the entire holding unit 31 is bendable, the degree of freedom of the shape of the holding unit 31 becomes too large, and the task of determining the position and angle of the one end 31a may become complicated. Therefore, it is preferable to provide a necessary and sufficient number of joint mechanisms 40 in the holding unit 31.

[0109] In the above embodiment, an example has been described in which the joint mechanism 40 includes the rod-shaped link 41 and the joint 42 that rotatably holds the link 41, but the present invention is not limited to this. In the present invention, the joint mechanism 40 may be constructed by connecting a plurality of joints in series without providing a link.

[0110] In the above embodiment, an example has been shown in which the joint 42 is a spherical joint, but the present invention is not limited to this. In the present invention, the joint 42 may be a universal joint. Alternatively, the joint 42 may be a one-degree-of-freedom rotational joint that can rotate the link only in a specific direction. In this case, it is preferable to combine the joints so that the rotation directions of the multiple joints are different from each other.

[0111] In the above embodiment, the holding portion 31 is provided with the guide portion 55 for guiding the light guide member 20, but the present invention is not limited to this. In the present invention, the guide portion 55 does not necessarily have to be provided.

[0112] In the above embodiment, the guide portion 55 is a groove formed on the outer surface of the one end 31a, but the present invention is not limited to this. FIG. 12 shows a second modified example in which the guide portion 55 is a protrusion formed on the outer surface of the one end 31a. In FIG. 12, the guide portion 55 is formed of a rib-shaped protrusion extending along the central axis of the one end 31a on the outer surface of the one end 31a. Both side surfaces of the protrusion are guide surfaces 55a. By arranging the light guide member 20 along either of the guide surfaces 55a, the emission end 22 can be precisely arranged in the direction of the central axis of the one end 31a.

[0113] In the above embodiment, an example has been described in which the light guide member 20 is held (fixed) to the one end 31a of the holder 31 by the ring-shaped fixing member 56, but the present invention is not limited to this. In the present invention, the light guide member 20 may be fixed to the one end 31a by a fixing means other than the fixing member 56. The fixing means is, for example, an adhesive tape, a pinch member, a cable tie, or the like. An engagement structure for engaging the light guide member 20 with the one end 31a of the holder 31 may be provided.

[0114] In the above embodiment, an example has been shown in which the holding portion 31 has the deformable member 50 that can be bent and deformed by an external force and can maintain its shape, but the present invention is not limited to this. In the present invention, the holding portion 31 does not need to be provided with the deformable member 50. As shown in Fig. 11, the tip of the link 41 may constitute the one end portion 31a.

[0115] In the above embodiment, the deformable member 50 constitutes the one end 31a, but the present invention is not limited to this. In the present invention, the deformable member 50 may be disposed at a position between the one end 31a and the other end 31b. For example, the deformable member 50 may be provided in place of the joint 42.

[0116] In the above embodiment, an example in which a plurality of holding parts 31 are provided has been shown, but the present invention is not limited to this. In the present invention, only one holding part 31 may be provided.

[0117] In the above embodiment, the holding portion 31 includes the first holding portion 31-1 having the first length L1 and the second holding portion 31-2 having the second length L2 that is greater than the first length L1, but the present invention is not limited to this. In the present invention, the multiple holding portions 31 may have the same length.

[0118] In the above embodiment, an example has been shown in which the number of joint mechanisms 40 in the holder 31 and the lengths of the links 41 connected to the joints 42 are changeable by configuring the joints 42 to be disassembled and assembled, but the present invention is not limited to this. The number of joint mechanisms 40 may be unchangeable. The links 41 connected to the joints 42 may be unchangeable (replaceable). In other words, the holder 31 may have a predetermined number of joint mechanisms 40 and the components may be unreplaceable.

[0119] In the above embodiment, an example is shown in which the base portion 32 is provided with the attachment portion 32b to which the holding portion 31 can be detached, but the present invention is not limited to this. In the present invention, the base portion 32 does not need to be provided with the attachment portion 32b. In other words, the holding portion 31 may be provided on the base portion 32 in a form that cannot be removed. For example, the other end portion 31b of the holding portion 31 may be joined to the base portion 32 by an irreversible method such as welding, fusion welding, or adhesion. The holding portion 31 and the base portion 32 may be integrally formed.

[0120] In the above embodiment, an example was shown in which the base portion 32 is provided with the operation unit 65 that switches between a fixed state in which the contact surface 32c is pressed against the structure 110 and a release state in which the pressing is released, but the present invention is not limited to this. In the present invention, the base portion 32 does not need to be provided with the operation unit 65. The base portion 32 may be attached to the structure 110 by, for example, screwing or adhesion (adhesive force). Also, the base portion 32 may be attached to the structure 110 by, for example, magnetic force or pressure (air pressure).

[0121] [Aspects] It will be appreciated by those skilled in the art that the exemplary embodiments described above are examples of the following aspects.

[0122] (Item 1) A light irradiation device for irradiating a treatment target site of a subject to which a drug containing a photosensitizer has been administered with therapeutic light, comprising: a light source unit that generates therapeutic light; a cable-shaped light guide member including an incident end connected to a light source unit and an exit end that emits light incident on the incident end; a holder having an arm-like shape, the holder having one end portion for holding the light emitting end of the light guiding member and another end portion opposite to the one end portion, the holder being provided so as to be capable of adjusting the position and angle of the one end portion; The light irradiation device further comprises a base portion that is attachable to a structure and supports the other end portion of the holding portion.

[0123] (Item 2) Item 2. The light irradiation device according to item 1, wherein the holding unit includes a plurality of joint mechanisms connected in series between one end and the other end.

[0124] (Item 3) Item 3. The light irradiation device according to item 2, wherein the joint mechanism includes a rod-shaped link and a joint that rotatably holds the link.

[0125] (Item 4) Item 4. The light irradiation device according to item 3, wherein the joint is constituted by a spherical joint.

[0126] (Item 5) One end has a rod-like shape, Item 2. The light irradiation device according to item 1, wherein the holding portion has a guide portion that guides the light-guiding member along a direction in which the one end portion extends.

[0127] (Item 6) 6. The light irradiation device according to item 5, wherein the guide portion is a groove or a protrusion formed on an outer surface of one end portion and has a guide surface on which a part of the light-guiding member can be positioned.

[0128] (Item 7) The holding portion has a deformable member that can be bent and deformed by an external force and can maintain its shape, 2. The light irradiation device according to item 1, wherein the deformable member constitutes one end of the holding portion.

[0129] (Item 8) the light source unit includes a plurality of light output ports to which the light guide members can be respectively connected; Item 2. The light irradiation device according to item 1, wherein the base portion includes a plurality of mounting portions to which the holding portions can be attached and detached, respectively.

[0130] (Item 9) 2. The light irradiation device according to item 1, wherein the holding portion includes a first holding portion having a first length and a second holding portion having a second length greater than the first length.

[0131] (Item 10) The base part is A contact surface capable of contacting a structure; an operation unit that switches between a fixed state in which the contact surface is fixed to the structure by pressing the contact surface against the structure and a release state in which the pressing is released; Item 2. The light irradiation device according to item 1, comprising:

[0132] (Item 11) a light guide member holder for holding a cable-shaped light guide member including an emission end for irradiating a therapeutic light to a treatment target site of a subject to which a drug containing a photosensitizer has been administered, a holder having an arm-like shape, the holder having one end portion for holding the light emitting end of the light guiding member and another end portion opposite to the one end portion, the holder being provided so as to be capable of adjusting the position and angle of the one end portion; The light-guiding member holder comprises: a base portion that is attachable to a structure and supports the other end portion of the holding portion. [Explanation of symbols]

[0133] 10 Light source section 12 Optical output port 20 Light guide member 21 Incidence end 22 Output end 30 Light guide member holder 31 Holding part 31-1 1st holding part 31-2 Second holding part 31a One end 31b Other end 32, 132 Base 32b Mounting part 32c contact surface 40(40a, 40b, 40c) Joint mechanism 41 Links 42 Joints 50 Deformable member 55 Guide part 65 Operation section 80 therapeutic light 100 Light irradiation device 101 Cancer patients (subjects) 101a Treatment area 102 Drugs 110 Structures

Claims

1. A light irradiation device for irradiating a treatment target site of a subject to which a drug containing a photosensitizer has been administered with therapeutic light, comprising: a light source unit that generates therapeutic light; a cable-shaped light guide member including an incident end connected to the light source unit and an exit end that emits light incident on the incident end; a holder having an arm shape, the holder having one end portion that holds the light emitting end of the light guiding member and another end portion opposite to the one end portion, the holder being provided so as to be capable of adjusting a position and an angle of the one end portion; a base portion that is attachable to a structure and supports the other end portion of the holding portion, The one end has a rod-like shape, The holding portion has a guide portion that guides the light guide member along a direction in which the one end portion extends.

2. A light irradiation device for irradiating a treatment target site of a subject to which a drug containing a photosensitizer has been administered with therapeutic light, comprising: a light source unit that generates therapeutic light; a cable-shaped light guide member including an incident end connected to the light source unit and an exit end that emits light incident on the incident end; a holder having an arm shape, the holder having one end portion that holds the light emitting end of the light guiding member and another end portion opposite to the one end portion, the holder being provided so as to be capable of adjusting a position and an angle of the one end portion; a base portion that is attachable to a structure and supports the other end portion of the holding portion, The base portion is A contact surface capable of contacting the structure; an operation unit that switches between a fixed state in which the contact surface is fixed to the structure by pressing the contact surface against the structure and a release state in which the pressing is released; A light irradiation device comprising:

3. The light irradiation device according to claim 1 , wherein the holding portion includes a plurality of joint mechanisms connected in series between the one end and the other end.

4. The light irradiation device according to claim 3 , wherein the joint mechanism includes a rod-shaped link and a joint that rotatably holds the link.

5. The light irradiation device according to claim 4 , wherein the joint is a spherical joint.

6. The light irradiation device according to claim 1 , wherein the guide portion is a groove or a protrusion formed on an outer surface of the one end portion, and has a guide surface on which a part of the light guide member can be disposed.

7. The holding portion has a deformable member that can be bent and deformed by an external force and can maintain its shape, The light irradiation device according to claim 1 or 2, wherein the deformable member constitutes the one end of the holding portion.

8. the light source unit includes a plurality of light output ports to which the light guide members can be respectively connected; The light irradiation device according to claim 1 , wherein the base portion includes a plurality of attachment portions to which the holding portions can be detachably attached.

9. The light irradiation device according to claim 1 , wherein the holding portion includes a first holding portion having a first length and a second holding portion having a second length greater than the first length.

10. a light guide member holder for holding a cable-shaped light guide member including an emission end for irradiating a therapeutic light to a treatment target site of a subject to which a drug containing a photosensitizer has been administered, a holder having an arm shape, the holder having one end portion that holds the light emitting end of the light guiding member and another end portion opposite to the one end portion, the holder being provided so as to be capable of adjusting a position and an angle of the one end portion; a base portion that is attachable to a structure and supports the other end portion of the holding portion, The one end has a rod-like shape, The holding portion has a guide portion that guides the light guide member along a direction in which the one end portion extends.

11. A light-guiding member holder for holding a cable-shaped light-guiding member including an emission end for irradiating a therapeutic light to a treatment target site of a subject to which a drug containing a photosensitive substance has been administered, comprising: a holder having an arm shape, the holder having one end portion that holds the light emitting end of the light guiding member and another end portion opposite to the one end portion, the holder being provided so as to be capable of adjusting a position and an angle of the one end portion; a base portion that is attachable to a structure and supports the other end portion of the holding portion, The base portion is A contact surface capable of contacting the structure; an operation unit that switches between a fixed state in which the contact surface is fixed to the structure by pressing the contact surface against the structure and a release state in which the pressing is released; A light guide member holder comprising:

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