Multi-stage gas dispensing actuation device and method

Abstract

Multi-stage gas dispensing actuator (100) and method A multi-stage gas dispensing actuator (100) is connected to a medication injection container (10). The device also includes a gas supply unit (1) for supplying gas, a push rod unit (2) consisting of a plurality of hollow tubes (21, 22, 23), one end of which is connected to the gas supply unit (1) and capable of extending the hollow tubes (21, 22, 23) with gas, a push rod tip (3) connected to the other end of the push rod unit (2) and pushing out the drug (13) as the hollow tubes (21, 22, 23) extend, a gas chamber (4) that penetrates the push rod unit (2) and is connected to the gas supply unit (1), is used to store gas, and further expands by extending the hollow tubes (21, 22, 23) as the gas increases, a position restriction part (5) located at the connecting end of the hollow tubes connected to each other and restricts the extension length of the hollow tubes (21, 22, 23), and an airtight member (9) located at the connecting end of the hollow tubes connected to each other and provides a sealing effect to the gas chamber (4).

Description

[Technical field]

[0001] The present invention relates to a multi-stage gas dispensing actuator, and more particularly to a dispensing actuator and method that require a small volume and prevent gas leakage. [Background technology]

[0002] Treatment of many chronic diseases requires subcutaneous administration of drugs or therapeutic agents in precisely controlled dosages, continuously or at specific time intervals. Subcutaneous injection is a common method for delivering drugs into the body, allowing the body to slowly absorb the drug over a longer period of time (compared to direct injection into blood vessels). Currently, pen-type or patch-type injectors using a main container (prefilled injector or prefilled syringe), such as pen-type injectors, autoinjectors, and wearable injectors, have already been developed, allowing users to self-inject drugs into their own bodies. However, these conventional pen-type injectors generate a propulsive force by a spring or a micromotor to deliver the drug. Therefore, the unstable driving force caused by the spring or motor may cause unexpected pain during the injection process.

[0003] In addition, some treatments require injection volumes greater than 1 ml, exceeding the injection volume limit of current subcutaneous injection devices. In addition, the injection speed is either too fast (several seconds) or too slow (several hours). For example, in conventional intravenous injection of protein drugs, the injection volume generally exceeds 30 ml, and can reach 250 ml. In addition, the injection time ranges from 30 minutes to several hours. Therefore, if the concentration of the protein drug can be increased to reduce the injection volume (1-20 ml) and a portable or wearable subcutaneous injection device can be provided to enable drug delivery at home, the patient's waiting time for injection can be saved and the convenience of treatment for patients can be improved. However, protein drugs cannot be concentrated indefinitely, and if the concentration of the protein is increased to the point where the solubility limit of the protein is exceeded, crystallization occurs and precipitation occurs. Therefore, many protein drugs for subcutaneous injection often require a therapeutic volume far exceeding 1 ml. In addition, when injected at a high flow rate, protein injection volumes exceeding 1 ml may cause swelling at the injection site or cause pain to the patient. Therefore, the maximum injection volume of conventional pen injectors or autoinjectors on the market is 1 ml. On the other hand, many wearable drug pump devices are driven by stepping motors (or similar members for rotating gears), but these motions are discrete (one revolution each time) and not continuous. Therefore, the base delivery flow rate provided by the stepping motor is also discrete (one drop each time). For example, a base rate in the range of 5-5000 nl / min (a typical dosing method for insulin) delivers 5 nl discretely each time, with a rate between one delivery per hour and 1000 deliveries per hour. Injecting 1 ml usually takes more than 3-6 hours at the fastest, so such an injection rate is too slow to meet the needs of patients (5-10 minutes).

[0004] Conventional electrochemical pumps usually provide a generated gas to a drug isolation member (e.g., a diaphragm or a movable barrier member) to directly act / force the drug out of its drug container, thus forming a complete drug delivery action. However, during this drug administration process, there is a risk that the electrochemically generated high pressure gas will leak from a leakage site of the isolation member (e.g., a defect on the diaphragm, container wall, or movable barrier member), resulting in contamination of the drug.

[0005] Therefore, there is an urgent need to develop a drug dispensing actuator that dispenses drugs at a gentle gas generation rate, does not pose a risk of drug contamination by gas, and has a small volume. Summary of the Invention [Problem to be solved by the invention]

[0006] SUMMARY OF THE DISCLOSURE In view of the above, the present invention provides a multi-stage gas dispensing actuation device and method that can be used in combination with different dispensing devices to solve the problems in the background art. [Means for solving the problem]

[0007] The multi-stage gas dispensing actuator of the present invention includes a gas supply unit for supplying gas to the device, a push rod unit composed of a plurality of hollow tubes and having one end connected to the gas supply unit, a push rod tip connected to the other end of the push rod unit, a gas chamber passing through the push rod unit and connected to the gas supply unit, a position regulating portion located at the connecting end of the hollow tubes connected to each other and for regulating the extension and contraction length of the plurality of hollow tubes, and an airtight member located at the connecting end of the hollow tubes connected to each other and for achieving the effect of sealing the gas chamber. Effect of the Invention

[0008] The gas supply unit of the present invention includes an electrochemical pump, which can release gas at a linear or nonlinear rate, and can release gas slowly to push the push rod unit. It should be noted that the present invention can administer according to the administration rate requirements of different injection sites and / or drugs, without causing discomfort to the recipient.

[0009] The multi-stage gas dispensing method of the present invention includes the following: the gas supply unit continuously supplies gas that increases at a linear or non-linear speed for a certain period of time, thereby injecting gas into the gas chamber covered by the push rod unit. With the increase in gas pressure received by the gas chamber, the hollow tubes of the push rod unit simultaneously extend at a linear or non-linear speed, and the pushing member structure is pushed by the extension of the push rod unit. When the gas supply unit continues to supply air, the position regulating part of the hollow tubes can regulate the extension length of one stage of the push rod unit. In addition, the pushing member structure can push out the medicine.

[0010] In addition, the airtight member of the present invention is located at the connecting end of the hollow tubes that are connected to each other. The airtight member prevents the gas from leaking from the gas chamber, so that contamination of the administered drug by the gas can be effectively prevented. [Brief description of the drawings]

[0011] [Figure 1] FIG. 1 is a schematic diagram of a multi-stage gas dispensing actuator. [Diagram 2] FIG. 2 is a schematic flow chart of a method of operating the multi-stage gas dosing system. [Diagram 3] FIG. 3 is a schematic diagram showing a case where a buffer gas chamber is provided and a case where the gas supply is separate. [Figure 4] FIG. 4 is a schematic diagram of a push rod unit consisting of small to large hollow tubes. [Diagram 5] FIG. 5 is a schematic diagram of a push rod unit made of a hollow tube of a different type. [Figure 6]FIG. 6 is a schematic diagram of a multi-stage hollow tube push rod unit. [Figure 7] FIG. 7 is a schematic diagram of a combination type of different sealing members and recessed designs. [Figure 8] FIG. 8 is a schematic diagram of the change in the force-receiving area of ​​the push rod unit. [Figure 9] FIG. 9 is a schematic diagram of a cylinder assembly and a hollow capillary tube. [Figure 10] FIG. 10 is a schematic diagram of the major and minor spiral patterns. [Figure 11] FIG. 11 is a schematic structural diagram of the coupling portion and buffer at the tip of the push rod. [Figure 12] FIG. 12 is a schematic diagram of a push rod unit with variations. [Figure 13] FIG. 13 is a schematic diagram of a medication actuator injection device. [Figure 14] FIG. 14 is a schematic diagram of a medication actuator injection device and a generic injection device. [Figure 15] FIG. 15 is a schematic diagram of different dosage rate curves. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0012] The following description will be given in more detail with reference to the accompanying drawings, in which: FIG. 1 is a perspective view of a casing of a casing according to an embodiment of the present invention;

[0013] The multi-stage gas dispensing actuator 100 of the present invention can be used in conjunction with a drug injection container 10, as shown in Figures 1 and 13. The device 100 includes:

[0014] The gas supply unit 1 supplies gas.

[0015] The push rod unit 2 is composed of a plurality of hollow tubes, one end of which is connected to the gas supply unit 1. These hollow tubes can be expanded by using gas.

[0016] The push rod tip portion 3 is connected to the other end of the push rod unit 2, and pushes the movable barrier member 15 as the hollow tubes expand, thereby further pushing out the drug 13.

[0017] The gas chamber 4 passes through the push rod unit 2 and is connected to the gas supply unit 1. The gas chamber 4 is used to store gas and expand the hollow tubes with the increase of gas.

[0018] When the gas supply unit 1 is not operating, the push rod unit 2 is in the shortest unextended state, and the extended length of the push rod unit 2 after the gas supply unit 1 supplies gas is smaller than the total length of the hollow tubes.

[0019] The gas supply unit 1 of the present invention includes an electrochemical pump, which can release gas at a linear or nonlinear rate, and can release gas slowly to push the push rod unit 2. It should be noted that the present invention can administer medication according to the administration rate requirements of different injection sites and / or drugs, without causing discomfort to the recipient.

[0020] In one embodiment of the present invention, the multi-stage gas dispensing operating method, as shown in FIG. 2, includes:

[0021] A1. The gas supply unit 1 continuously supplies gas over a period of time, with the gas increasing at a linear or non-linear rate.

[0022] A2. Gas is injected into the gas chamber 4 covered by the push rod unit 2.

[0023] A3. With an increase in the gas pressure received by the gas chamber 4, the hollow tubes of the push rod unit 2 simultaneously expand according to a linear or non-linear speed.

[0024] A4. The extension of the push rod unit 2 is used to push the movable barrier member 15 of the drug injection container, thereby pushing out the drug 13.

[0025] Preferably, the movable barrier member 15 comprises a rubber plug and a piston.

[0026] In one embodiment of the present invention, in the multi-stage gas dispensing actuator 100 shown in Fig. 3, the hollow tubes of the push rod unit 2 have an airtight member 9 and a position restricting unit 5 at the connecting ends of the hollow tubes that are connected to each other. The airtight member 9 prevents gas from leaking from the gas chamber 4, so that contamination of the administered medicine by gas can be effectively prevented. In addition, the position restricting unit 5 restricts the extension length of the hollow tubes.

[0027] In one embodiment of the present invention, in the multi-stage gas dispensing actuator 100, as shown in Fig. 3, the gas supply unit 1 is further connected to a buffer gas chamber 7 and then to a push rod unit 2. The buffer gas chamber 7 prevents the gas generated in the gas supply unit from directly impacting the push rod unit 2, thereby achieving gentle extension of the push rod unit 2. Note that the shape of the buffer gas chamber 7 shown in the figure is merely one embodiment, and the present invention is not limited to this shape.

[0028] In one embodiment of the present invention, in the multi-stage gas dispensing actuator 100, as shown in FIG. 3, the gas supply unit 1 may be of separate design and connected to the push rod unit 2 through a connecting tube.

[0029] In one embodiment of the present invention, the push rod unit 2 is composed of hollow tubes whose diameters change from large to small. The inner diameter of the Nth hollow tube is slightly larger than the outer diameter of the N+1th hollow tube, so that the N+1th hollow tube can slide within the Nth hollow tube. N is the number of segments of the hollow tube 20 and is an integer greater than 0.

[0030] In one embodiment of the present invention, as shown in Fig. 1, the push rod unit 2 is composed of three stages of hollow tubes. The first hollow tube 21 has one end connected to the gas supply unit 1 and the other end connected to the second hollow tube 22. The outer diameter of the second hollow tube 22 is slightly smaller than the inner diameter of the first hollow tube 21, allowing the second hollow tube 22 to slide within the first hollow tube 21. The third hollow tube 23 is connected to the second hollow tube 22. The outer diameter of the third hollow tube 23 is slightly smaller than the inner diameter of the second hollow tube 22, allowing the third hollow tube 23 to slide within the second hollow tube 22. The other end of the third hollow tube 23 is connected to the push rod tip 3.

[0031] In one embodiment of the present invention, the push rod unit 2 is composed of hollow tubes whose diameters change from small to large. The outer diameter of the Nth hollow tube is slightly smaller than the inner diameter of the N+1th hollow tube, so that the Nth hollow tube can slide within the N+1th hollow tube. N is the number of segments of the hollow tube 20 and is an integer greater than 0.

[0032] In one embodiment of the present invention, as shown in Fig. 4, the push rod unit 2 is composed of three stages of hollow tubes. The first hollow tube 21 has one end connected to the gas supply unit 1 and the other end connected to the second hollow tube 22. The outer diameter of the first hollow tube 21 is slightly smaller than the inner diameter of the second hollow tube 22, allowing the first hollow tube 21 to slide within the second hollow tube 22. The third hollow tube 23 is connected to the second hollow tube 22. The outer diameter of the second hollow tube 22 is slightly smaller than the inner diameter of the third hollow tube 23, allowing the second hollow tube 22 to slide within the third hollow tube 23. The other end of the third hollow tube 23 is connected to the push rod tip 3.

[0033] In one embodiment of the present invention, the push rod unit made of different types of hollow tubes is configured as shown in the right diagram of FIG. 5, in which the push rod unit 2 is composed of three stages of hollow tubes. The first hollow tube 21 is connected at one end to the gas supply unit 1 and at the other end to the second hollow tube 22. The outer diameter of the first hollow tube 21 is slightly smaller than the inner diameter of the second hollow tube 22, allowing the first hollow tube 21 to slide within the second hollow tube 22. The third hollow tube 23 is connected to the second hollow tube 22. The inner diameter of the second hollow tube 22 is slightly larger than the outer diameter of the third hollow tube 23, allowing the third hollow tube 23 to slide within the second hollow tube 22. The other end of the third hollow tube 23 is connected to the push rod tip 3.

[0034] In one embodiment of the present invention, the push rod unit made of different types of hollow tubes is configured as shown in the left diagram of FIG. 5, in which the push rod unit 2 is composed of three stages of hollow tubes. The first hollow tube 21 is connected at one end to the gas supply unit 1 and at the other end to the second hollow tube 22. The inner diameter of the first hollow tube 21 is slightly larger than the outer diameter of the second hollow tube 22, allowing the second hollow tube 22 to slide within the first hollow tube 21. The third hollow tube 23 is connected to the second hollow tube 22. The outer diameter of the second hollow tube 22 is slightly smaller than the inner diameter of the third hollow tube 23, allowing the second hollow tube 22 to slide within the third hollow tube 23. The other end of the third hollow tube 23 is connected to the push rod tip 3.

[0035] In one embodiment of the present invention, the multi-stage hollow tube push rod unit may be configured as shown in FIG. 6, in which the push rod unit 2 is composed of multiple hollow tubes including two stages of hollow tubes (shown in the left diagram of FIG. 6) and four stages of hollow tubes (shown in the right diagram of FIG. 6). The length of the two stages of hollow tubes when unextended is half of the total length. Also, the length of the four stages of hollow tubes when unextended is a quarter of the total length. Therefore, according to the present invention, it is possible to effectively reduce the size of the device and save space.

[0036] Preferably, the push rod unit 2 of the multi-stage gas dispensing actuator 100 is collapsible to an unextended length of up to 1 mm.

[0037] Preferably, the contact area of ​​the hollow tube changes depending on the shape and material of the airtight member 9, and further affects the expansion speed of the hollow tube. The contact area is formed by the airtight member 9 coming into close contact with the hollow tube. Moreover, the contact area is inversely proportional to the expansion speed of the hollow tube.

[0038] In one embodiment of the present invention, as shown in FIG. 7, the multi-stage gas dispensing actuator 100 has an airtight member 9 having a circular, rectangular, elliptical, polygonal, X-shaped, etc. shape, and the hollow tube has a different extension speed depending on the shape.

[0039] In the above embodiment, the airtight members 9 may be used in an alternating combination. For example, as shown in FIG. 7, a plurality of modes may be used in combination. The extension speed of the plurality of hollow tubes for each combination type is determined by the type of the airtight member 9. It should be noted that, for such a combination design, it is possible to design a time-speed curve of drug administration that causes the least discomfort to the person receiving the drug, depending on the difference in the properties of the drug and / or the difference in the tissue characteristics of the subcutaneous site to be administered.

[0040] 7, the airtight member 9 may be used in combination with one or more backup rings 91. This can improve the amount of deformation of the airtight member 9 when the hollow tube expands and contracts under high pressure.

[0041] 7, the position regulating portion 5 is preferably designed to have a concave shape, and the height of the concave side is lower than the height of the airtight member 9. This strengthens the positioning of the airtight member 9 and reliably guarantees airtightness.

[0042] In one embodiment of the present invention, as shown in Fig. 8, the relationship between the area (A) receiving the gas pressure (P) discharged from the gas supply unit 1 and the normal force (F) can be indirectly changed by directly designing the hollow tubes of the push rod unit to have different tube diameter sizes and / or different tube wall thicknesses. The formula is as follows:

[0043] Pressure (P)=normal force (F) / force-receiving area (A), P=F / A

[0044] When a constant pressure (P) is supplied from the gas supply unit 1, the force-receiving area (A) is directly proportional to the extension speed and normal force (F), and the larger the force-receiving area (A), the faster the extension speed. Furthermore, by changing the ratio of the inner diameter and the wall thickness of the multiple hollow tubes, and by changing and controlling the extension sequence and speed of the multiple hollow tubes, a variable and controllable dosing speed curve can be realized.

[0045] In one embodiment of the present invention, the four-stage gas dispensing actuator is configured by combining a push rod unit 2 with a drug injection container 10 as shown in FIG. 8, and can realize different dispensing speed curves. The first hollow tube 21 is fixedly connected to the gas supply unit 1, and a constant pressure (P) is supplied from the gas supply unit 1. In the first stage, the push rod unit has a maximum force-receiving area (A1) and a maximum normal force (F1) when unextended (A1= The fourth hollow tube 24 The area of ​​the push rod tip 3 + the wall thickness of the second and third hollow tubes 22, 23 *2) 1 st. In the second stage, the force receiving area (A2= The fourth hollow tube 24 The area of ​​the push rod tip 3 + the wall thickness of the third hollow tube 23 *2) results in the second largest flow rate. 2 nd. In the third stage, the third hollow tube 23 When the load is stretched, the force-receiving area (A3 = The fourth hollow tube 24 The area of ​​the push rod tip 3) has the smallest flow rate. 3 rd. Figure 15 shows the relationship between time and the drug flow rate.

[0046] In one embodiment of the present invention, the roughness of the inner surface of the hollow tubes of the push rod unit can be designed according to the actual stretching sequence and stretching speed. The roughness of the inner surface of the hollow tubes and the stretching speed of the hollow tubes are inversely proportional (the larger the roughness, the slower the stretching speed), so that the roughness ratio of the inner surface of these hollow tubes can be changed and controlled to change and control the stretching sequence and speed of the hollow tubes, thereby achieving a variable and controllable dosing speed curve.

[0047] In one embodiment of the present invention, in the multi-stage gas dispensing actuator 100, as shown in the left diagram of Fig. 9, the final stage of the push rod unit 2 is a column assembly 8. Since the column assembly 8 does not have a gas chamber 4, the gas directly presses one end of the column assembly 8. The other end of the column assembly 8 is the push rod tip 3.

[0048] In one embodiment of the present invention, in the multi-stage gas dispensing actuator 100, as shown in the right diagram of FIG. 9, the first hollow tube 21 may have a capillary hollow tube 14 structure.

[0049] In one embodiment of the present invention, in the multi-stage gas dispensing actuator 100, the inner wall of the hollow tube 20 of the push rod unit 2 may have a plurality of helical patterns, so that the hollow tube of the push rod unit 2 can be extended in a helical manner, as shown in the cross-sectional view of the hollow tube in Figure 10. The helical patterns include a small helical pattern 11 and a large helical pattern 12.

[0050] In one embodiment of the present invention, as shown in Figure 11, a coupling part 31 is connected to the push rod tip 3, which is equipped with multiple types of pushing member structures 6 to lock the movable barrier member 15 and assist in pushing out the drug. The pushing member structures 6 include a lock for the movable barrier member, a lock for the push rod tip, and a lock for the movable barrier member and the push rod tip.

[0051] In one embodiment of the present invention, as shown in Fig. 11, a buffer 92 is attached to one end of the hollow tube, and one or more holes can penetrate the buffer 92. By attaching a buffer 92 with a different number of holes to the hollow tube of each stage, the order and speed of expansion of the hollow tube of each stage can be changed. In addition, by making the holes from micro-nano level to micro level holes, it is possible to control different gas passing speeds.

[0052] As shown in FIG. 12, an embodiment of the present invention can be realized by combining the buffer 92 with different types of airtight members 9 and hollow tubes 20 of different lengths. In the structure formed by the push rod unit 2 in an embodiment of the present invention, the length of the second hollow tube 22 is longer than the length of the third hollow tube 23. In addition, the first hollow tube 21 and the second hollow tube 22 use circular airtight members 9, and the second hollow tube 22 and the third hollow tube 23 use rectangular airtight members 9. A buffer 92 is attached to one end of the second hollow tube 22. Due to the action of the buffer 92, the gas generated in the gas supply unit 1 first fills the section of the second hollow tube 22 in the gas chamber 4. In addition, the contact area between the circular airtight member 9 and the first hollow tube 21 is smaller than the contact area between the rectangular airtight member 9 and the third hollow tube 23. Therefore, the second hollow tube 22 first extends to the length of the first hollow tube 21. Next, gas further fills the section of the third hollow tube 23 in the gas chamber 4, but due to the rectangular airtight member 9, the expansion speed is slower than that of the second hollow tube 22. According to the present invention, a relatively large amount of the drug 13 is first pushed out at a relatively fast speed, and then a relatively small amount of the drug 13 is pushed out at a relatively slow speed.

[0053] As mentioned above, by changing the length, diameter, and roughness of the hollow tube, combining the shapes of the airtight member 9, and adding different combinations of buffers 92, different dosage rate curves can be achieved.

[0054] In one embodiment of the present invention, as shown in Fig. 13, a drug injection device 200 is constructed by combining a multi-stage gas injection actuator 100 with a drug injection container 10 including a movable barrier member, and is usable. The gas supply unit 1 is also combined as an electrochemical pump. The device can be mounted on an automatic injection device.

[0055] In the above embodiment, the electrochemical pump slowly generates gas to gently push out the medicine in the injection device 200. This prevents discomfort during the injection process for patients who need to continuously inject small amounts of medicine over a long period of time. Currently, when a small amount of medicine is continuously injected over a long period of time, the injection amount and injection time are controlled by a nurse, but this problem can be solved by using the present invention.

[0056] In one embodiment of the present invention, for example as shown in FIG. 14, when a medication actuating device injection device 200 formed by combining a multi-stage gas medication actuating device 100 of the present invention with the medication injection container 10 is compared with a general injection device 300, the length of the injection device of the present invention can be effectively shortened.

[0057] The above description is merely an embodiment of the present invention, and does not limit the scope of protection of the present invention. Any equivalent implementation of other modifications made based on the contents, features and spirit of the claims of the present invention shall be included in the scope of protection of the present invention. [Explanation of symbols]

[0058] 1 Gas supply unit 2 Push rod unit 3 Push rod tip 4. Gas Chambers 5 Position regulation part 6 Push-motion member structure 7. Buffer Gas Chambers 8 Column assembly 9 Airtight materials 10 Drug injection containers 11 Small Spiral Pattern 12 Great Spiral Pattern 13 Drugs 14 Capillary hollow tube 15 Movable barrier member 20 hollow tube 21 1st hollow tube 22 2nd hollow tube 23 Third hollow tube 24 4th hollow tube 31 Joint 91 Backup Ring 92 Buffer 100 Multi-stage gas dispensing actuator 200 Medication actuator injection device 300 General Injection Equipment A1-A4 Flow of multi-stage gas dispensing operation method

Claims

1. 1. A multi-stage gas dispensing actuator connected to a medication injection container, comprising: a gas supply unit including an electrochemical pump and capable of supplying a gas; a push rod unit having one end connected to a gas supply unit and composed of a plurality of hollow tubes having different diameters, the outer diameter of a first hollow tube being slightly smaller than the inner diameter of a second hollow tube, and capable of sliding the first hollow tube within the second hollow tube; a gas chamber passing through the push rod unit and connected to a gas supply unit, the gas chamber being used to contain gas and further expanding by stretching the plurality of hollow tubes with increasing gas; and A multi-stage gas dispensing actuator including a push rod tip connected to the other end of the push rod unit, which pushes a movable barrier member as the multiple hollow tubes extend, thereby further pushing out the medication.

2. 2. The multi-stage gas dispensing actuator of claim 1, wherein the second hollow tube of the push rod unit is connected to a third hollow tube, and the outer diameter of the third hollow tube is slightly smaller than the inner diameter of the second hollow tube, so that the third hollow tube can slide within the second hollow tube.

3. 1. A multi-stage gas dispensing actuator connected to a medication injection container, comprising: a gas supply unit including an electrochemical pump and capable of supplying a gas; a push rod unit having one end connected to a gas supply unit and composed of a plurality of hollow tubes having different diameters, the inner diameter of a first hollow tube being slightly larger than the outer diameter of a second hollow tube, and capable of sliding the second hollow tube within the first hollow tube; a gas chamber that passes through the push rod unit and is connected to the gas supply unit, the gas chamber being used to contain gas and further expandable by extending the plurality of hollow tubes with the increase of gas; A multi-stage gas dispensing actuator including a push rod tip connected to the other end of the push rod unit, which pushes the movable barrier member as the multiple hollow tubes extend, thereby further pushing out the medication.

4. 4. The multi-stage gas dispensing actuator of claim 3, wherein the second hollow tube of the push rod unit is connected to a third hollow tube, and the inner diameter of the third hollow tube is slightly larger than the outer diameter of the second hollow tube, so that the second hollow tube can slide within the third hollow tube.

5. The multi-stage gas dispensing actuator of claim 1 or 3 further comprises a gas supply unit connected to a buffer gas chamber and then connected to a push rod unit, a buffer is attached to one end of the plurality of hollow tubes of the push rod unit, and one or more holes can pass through the buffer.

6. A multi-stage gas dispensing actuator as described in claim 1 or 3, wherein the tube diameter size and tube wall thickness of the multiple hollow tubes of the push rod unit form a force-receiving area, the force-receiving area and the extension speed are directly proportional to each other, the larger the force-receiving area, the faster the extension speed, and the surface roughness within the multiple hollow tubes and the extension speed of the multiple hollow tubes are inversely proportional to each other, the larger the roughness, the slower the extension speed.

7. A multi-stage gas dispensing actuator as described in claim 1 or 3, wherein the multiple hollow tubes have an airtight member and a position control portion at the connection ends of the multiple hollow tubes that are connected to each other, the position control portion being concave, and the height of the concave side edge is lower than the height of the airtight member to ensure airtightness.

8. 4. The multi-stage gas dispensing actuator as claimed in claim 1 or 3, wherein the plurality of hollow tubes have a plurality of helical patterns, and the plurality of hollow tubes of the push rod unit can be extended along the helical directions.

9. 4. A multi-stage gas dispensing actuator as described in claim 1 or 3, in which the final stage of the push rod unit is a column assembly, the gas directly presses against the column assembly, and the tip of the push rod presses against the movable barrier member. The dispensing actuator injection device is capable of being attached to an automatic injection device.

10. 1. A method of operating a multi-stage gas dosing system, comprising: A1. A gas supply unit continuously supplies gas at a linear or non-linear rate over a period of time; A2. Gas is injected into the gas chamber covered by the push rod unit, A3. As the gas pressure received by the gas chamber increases, the hollow tubes of the push rod unit simultaneously expand at a linear or nonlinear rate. A4. By utilizing the extension of the push rod unit, the tip of the push rod pushes the movable barrier member of the drug injection container, thereby pushing out the drug; The method includes:

11. The multi-stage gas dispensing actuation method according to claim 10, wherein the gas supply unit is connected to the buffer gas chamber and then to the push rod unit, thereby avoiding the gas from directly impacting the gas chamber.

12. A multi-stage gas dispensing operating method as described in claim 10, wherein a buffer is attached to one end of each of the hollow tubes, and one or more holes can penetrate the buffer, and by attaching a buffer with a different number of holes to each stage of hollow tubes, the extension order and speed of each stage of hollow tubes can be changed.

13. The multi-stage gas dispensing operating method of claim 10, wherein the tube diameter size and tube wall thickness of the multiple hollow tubes of the push rod unit form a force-receiving area, the force-receiving area and the extension speed are directly proportional to each other, the larger the force-receiving area, the faster the extension speed; the multiple hollow tubes can adjust the extension speed of the multiple hollow tubes by changing the roughness of their inner surfaces, the roughness of the inner surface of the hollow tubes and the extension speed of the hollow tubes are inversely proportional to each other, the larger the roughness, the slower the extension speed.

14. The method for operating a multi-stage gas dispensing system according to claim 10, wherein the plurality of hollow tubes have an airtight member at the connection ends of the plurality of hollow tubes that are connected to each other, and the contact area of ​​the airtight member that is in close contact with the plurality of hollow tubes is inversely proportional to the expansion speed of the hollow tubes.

15. The multi-stage gas dispensing actuation method according to claim 10, wherein a coupling portion is connected to the tip of the push rod, which can be fitted with a plurality of types of pushing member structures to assist in pushing, and the dispensing actuation device injection device in which the tip of the push rod pushes the movable barrier member can be attached to an automatic injection device.

Images