container

Abstract

To provide a container for enabling re-sealing while keeping a state of an opening part after the container is opened once.SOLUTION: A container 100 comprises: a storage part 20 which defines a storage space 22 and a first opening 24 communicating with the storage space 22; and a passage part 60 which defines a partition wall 40 for blocking the first opening 24 and to be punctured, a second opening 64 connected to the first opening 24 by holding the partition wall 40 between the openings, the third opening 66, and a passage 62 for allowing the second opening 64 to communicate with the third opening 66, and also which includes a sealing area 68 to block the passage 62.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a container. [Background technology]

[0002] Liquids such as cell suspensions, pharmaceutical liquids, and food-related liquids need to be prevented from being contaminated by foreign matter, bacteria, and the like. Therefore, containers that store these liquids are required to have high airtightness. For example, in a general container that opens and closes with a screw-type lid, bacteria, etc. may enter the container body through the gap between the container body and the lid, and the airtightness may be insufficient. Therefore, Patent Document 1 proposes a container as a cryopreservation container for biological samples that is difficult for bacteria, etc. to enter, which includes a container body, an opening that communicates with the inside of the container body and can be sealed by welding, and an opening part that communicates with the inside of the container body by opening. In the cryopreservation container of Patent Document 1, after the biological sample is introduced into the container body through the opening, the opening is sealed by welding. The biological sample is removed from the container body by opening the opening part by breaking or melting it. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 5011810 Summary of the Invention [Problem to be solved by the invention]

[0004] When using only a portion of the contents contained in a container, it may be necessary to take out the necessary amount of contents from the container and then seal the container again. There is also a demand to preserve the state of the opened portion so that the state when the contents were taken out can be checked later. However, with the container described in Patent Document 1, it is difficult to reseal the container while preserving the state of the opened portion after it has been opened once.

[0005] The present invention has been made in consideration of the above points, and has an object to provide a container that can be resealed after being opened once while maintaining the state of the opening portion. [Means for solving the problem]

[0006] A container according to one embodiment of the present invention includes a storage section defining a storage space and a first opening communicating with the storage space, a puncturable partition wall blocking the first opening, a second opening connected to the first opening via the partition wall, a third opening, and a passage section defining a passage communicating between the second opening and the third opening and having a seal area capable of blocking the passage. Effect of the Invention

[0007] The container of the present invention can be opened by puncturing the septum and then resealed while maintaining the integrity of the septum. [Brief description of the drawings]

[0008] [Figure 1] FIG. 1 is a schematic cross-sectional view showing an example of a container according to an embodiment. [Diagram 2] FIG. 2 is a schematic cross-sectional view showing another example of the container according to the embodiment. [Diagram 3] FIG. 3 is a schematic cross-sectional view showing another example of the container according to the embodiment. [Figure 4] FIG. 4 is a schematic top view showing an example of a passage portion of a container according to the embodiment. [Diagram 5] FIG. 5 is a schematic cross-sectional view showing another example of the container according to the embodiment. [Figure 6A] FIG. 6A is a diagram illustrating an example of a method for manufacturing a container according to an embodiment. [Figure 6B] FIG. 6B is a diagram illustrating an example of a method for manufacturing a container according to an embodiment. [Figure 7A] FIG. 7A is a diagram illustrating an example of a method of using a container according to an embodiment. [Figure 7B]FIG. 7B is a diagram illustrating an example of a method of using the container according to the embodiment. [Figure 7C] 7C is a diagram illustrating an example of a method of using the container according to the embodiment, and is a schematic cross-sectional view taken along line VII-VII in FIG. 7B. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] (1) Container First, a container according to an embodiment will be described with reference to Figures 1 to 5. As shown in Figure 1, a container 100 according to an embodiment includes a storage section 20, a partition wall 40, and a passage section 60. Hereinafter, the direction perpendicular to the center of the partition wall 40 will be referred to as the Z direction as appropriate.

[0010] The storage unit 20 defines a storage space 22 for storing a biological sample or the like, and a first opening 24 communicating with the storage space 22. The storage unit 20 has an inner surface 21 surrounding the storage space 22, and an outer surface 23. The first opening 24 is sealed without any gaps by a partition wall 40. As a result, the storage space 22 is surrounded by the inner surface 21 of the storage unit 20 and a surface 41 of the partition wall 40 facing the storage space 22, forming a closed space. In the present application, the term "closed space" refers to a space that is closed from the external environment so as to prevent contamination by foreign matter, bacteria, or the like from the external environment, for example, a sealed space that is sealed from the external environment.

[0011] The storage section 20 is formed from any material that can make the storage space 22 a closed space, and is preferably formed from a material that has a transparency sufficient to enable confirmation of the presence or absence of liquid in the storage space 22. For example, it may be formed from a plastic material such as a polyolefin resin such as polyethylene or polypropylene, polyvinyl chloride, ethylene-vinyl acetate copolymer resin, C-FLEX (registered trademark), or polystyrene, as well as glass.

[0012] The storage section 20 has any shape that defines the storage space 22 and the first opening 24. For example, in the container 100 according to the embodiment shown in FIG. 1, the inner surface 21 of the storage section 20 includes a surface (vertical surface) 21a that is parallel to the Z direction and directly contacts the partition wall 40. On the other hand, in the container 102 according to the embodiment shown in FIG. 2, the inner surface 21 of the storage section 20 includes a vertical surface 21a that directly contacts the partition wall 40 and an inclined surface 21b that is inclined with respect to the Z direction and directly contacts the vertical surface 21a. Here, the inclined surface 21b is a surface that is inclined so that the area of ​​a cross section of the storage space 22 perpendicular to the Z direction becomes smaller as it moves away from the first opening 24. In another embodiment, the inner surface of the storage section may include an inclined surface that is inclined with respect to the Z direction and directly contacts the first surface of the partition wall. Note that the inclined surface is a surface that is inclined so that the area of ​​a cross section of the storage space perpendicular to the Z direction becomes smaller as it moves away from the first opening, similar to the embodiment shown in FIG. 2.

[0013] The inclusion of a vertical surface and / or an inclined surface on the inner surface 21 of the storage section 20 that directly contacts the partition 40 has the following advantages. That is, when taking out the contents in the storage space 22, it is generally desirable to penetrate a needle such as a bottle needle in a direction perpendicular to the partition 40 in order to prevent the occurrence of coring. When the inner surface 21 of the storage section 20 includes a vertical surface and / or an inclined surface, if the angle between the needle and the partition 40 is equal to or smaller than a predetermined angle, the needle comes into contact with the vertical surface or the inclined surface of the inner surface 21 of the storage section 20 and does not reach the depth of the storage space 22. Therefore, the operator can determine whether the needle penetration direction was appropriate. Note that coring refers to fine fragments of the partition 40 that are mixed into the flow path inside the needle when the needle penetrates the partition 40.

[0014] The partition 40 completely blocks the first opening 24 of the storage section 20. The partition 40 can make the storage space 22 a closed space and is formed from any material that can be punctured by a needle or the like. For example, the partition 40 is desirably formed from a material suitable for puncturing, and may be formed from a plastic material, for example, a polyolefin resin such as polyethylene or polypropylene, polyvinyl chloride, ethylene-vinyl acetate copolymer resin, C-FLEX (registered trademark), polystyrene, or the like.

[0015] The partition 40 has any structure that can make the storage space 22 a closed space and can be punctured by a needle or the like. For example, the partition 40 may be a flat plate or a plate having a curved surface. The thickness of the partition 40 may be less than 1000 μm so that the partition 40 can be easily punctured by a needle. In order to suppress the occurrence of coring, the thickness of the partition 40 may be less than 320 μm, preferably 180 μm or less. In addition, the thickness of the partition 40 may be 50 μm or more so that the partition 40 can be easily manufactured and has sufficient strength.

[0016] The passage portion (passage wall) 60 defines a second opening 64 connected to the first opening 24 with the partition wall 40 in between, a third opening 66, and a passage 62 connecting the second opening 64 and the third opening 66. The second opening 64 is completely closed by the partition wall 40, and the first opening 24 and the second opening 64 are separated by the partition wall 40. On the other hand, the third opening 66 is open. As a result, the passage 62 is connected to the external environment via the third opening 66.

[0017] The passage portion 60 has an inner surface 61 surrounding the passage 62 and an outer surface 63. The passage portion 60 has any shape that allows a needle to pierce the partition wall 40 from the outside of the container 100 through the third opening 66 and the passage 62. For example, the passage portion 60 may have a substantially cylindrical shape having an axis parallel to the Z direction. The shape of the cross section perpendicular to the Z direction of the inner surface 61 and the outer surface 63 of the passage portion 60 may be any shape such as a circle, an ellipse, a polygon, etc. The shape and dimensions of the cross section perpendicular to the Z direction of the inner surface 61 and the outer surface 63 of the passage portion 60 may be the same at any Z direction position or may differ depending on the Z direction position. In the embodiment shown in FIG. 1, the inner surface 61 of the passage portion 60 includes an inclined surface 61a inclined with respect to the Z direction. Here, the inclined surface 61a is a surface that is inclined so that the area of ​​the cross section of the passage 62 perpendicular to the Z direction becomes smaller as it approaches the second opening 64 from the third opening 66, that is, a surface that is inclined so that the passage 62 narrows from the third opening 66 to the second opening 64. In the embodiment shown in FIG. 1, the inner surface 61 of the passage portion 60 includes a surface 61b parallel to the Z direction and a surface 61c perpendicular to the Z direction between the inclined surface 61a and the second opening 64 (i.e., between the inclined surface 61a and the partition wall 40). However, the surfaces 61b and 61c between the inclined surface 61a and the second opening 64 are not essential. In the embodiment shown in FIG. 2, the inner surface 61 of the passage portion 60 includes an inclined surface 61a inclined with respect to the Z direction, and the inclined surface 61a is in direct contact with the partition wall 40.

[0018] The inclusion of the inclined surface 61a inclined with respect to the Z direction on the inner surface 61 of the passage portion 60 has the following advantage. That is, when removing the contents from the storage space 22, it is generally desirable to pass a needle such as a bottle needle through the partition 40 in a direction perpendicular to the partition 40 in order to prevent the occurrence of coring. The inclined surface 61a of the inner surface 61 of the passage portion 60 guides the needle through the partition 40 in a direction perpendicular to the partition 40. This makes it easier for the operator to pass the needle through the partition 40 in a direction perpendicular to the partition.

[0019] 1, when the inner surface 61 includes a surface 61c perpendicular to the Z direction, the partition 40 is highly visible from the third opening 66 side, and the passage 62 is wide, making it easy to guide the needle to the partition 40. On the other hand, when the inner surface 61 does not include a surface 61c perpendicular to the Z direction, when the inner surface 61 does not include a surface 61c perpendicular to the Z direction, there is no surface parallel to the partition 40 in the vicinity of the partition 40, so that it is possible to prevent an operator from sticking a needle into the portion of the inner surface 61 of the passage portion 60 in the vicinity of the partition 40.

[0020] The passage portion 60 has a seal area 68 capable of closing the passage 62. The seal area 68 is a band-shaped area provided around the circumferential direction of the substantially cylindrical passage portion 60. Any method may be used to close the passage 62 with the seal area 68. For example, in the seal area 68, the passage portion 60 may be overlapped so that the opposing inner surfaces 61 of the passage portion 60 come into contact with each other, and the opposing inner surfaces 61 may be bonded to each other, thereby closing the passage 62. The opposing inner surfaces 61 may be bonded to each other by heat sealing. Here, heat sealing refers to bonding by heating. Examples of the heating method include, but are not limited to, a method of applying high frequency, ultrasonic waves, or the like, and a method of using a hot plate, hot air, or the like.

[0021] When the passage 62 is closed using a heat sealer, in order to bond the inner surfaces 61 of the passage portion 60 with sufficient adhesive strength, the sealing region 68 may have a length of 2 mm or more, preferably 5 mm or more, more preferably 10 mm or more in the direction from the third opening 66 toward the second opening 64, and the thickness of the passage portion 60 in the sealing region 68 may be 500 μm or less, preferably 300 μm or less. In addition, when the passage portion 60 has a weld line described later and the position of the weld line is not in the vicinity of the bent portion (bent portion) 67 in the sealing region 68, the thickness of the passage portion 60 in the sealing region 68 may be in the range of more than 300 μm and not more than 500 μm, as shown in the examples described later.

[0022] As shown in FIG. 1, the passage portion 60 may have a uniform thickness in the sealing region 68. In the present application, the term "uniform thickness" is a concept including a substantially uniform thickness, and specifically means that the difference between the maximum and minimum thickness values ​​is 10% or less of the average thickness value. When the thickness of the passage portion 60 in the sealing region 68 is uniform, the inner surfaces 61 of the passage portion 60 can be reliably bonded to each other with sufficient adhesive strength even if the installation position of the heat sealer varies in the Z direction. In particular, the difference between the maximum and minimum thickness values ​​may be 3% or less of the average thickness value. In this case, the thickness of the passage portion 60 in the sealing region 68 is particularly uniform, and the inner surfaces 61 of the passage portion 60 are smooth. Therefore, the variation in adhesive strength can be suppressed, and the inner surfaces 61 of the passage portion 60 can be more reliably bonded to each other with sufficient adhesive strength.

[0023] 3, in the sealing region 68, the passage portion 60 may have a region in which the thickness increases from the third opening 66 toward the second opening 64. Such a shape has the advantage that it can be easily formed by injection molding.

[0024] The material of the passage 60 is any material that makes the passage 62 a closed space when the passage 62 is closed by the sealing region 68. For example, the passage 60 may be made of a plastic material, such as a polyolefin resin such as polyethylene or polypropylene, polyvinyl chloride, ethylene-vinyl acetate copolymer resin, C-FLEX (registered trademark), polystyrene, glass, or the like. The material of the sealing region 68 is a material that can close the passage 62, such as a material that can be heat-sealed. For example, the sealing region 68 is desirably made of a material suitable for sealing, and may be made of a plastic material, such as a polyolefin resin such as polyethylene or polypropylene, polyvinyl chloride, ethylene-vinyl acetate copolymer resin, C-FLEX (registered trademark), polystyrene, or the like.

[0025] When the passage portion 60 is made of a plastic material, the passage portion 60 can be formed by injection molding as described below. When the passage portion 60 is formed by injection molding, the passage portion 60 generally includes a weld line. A weld line means a mark formed by the fusion of the molten material flows in a mold for injection molding, and is also called a meld line. A weld line is usually linear, but may be dotted or dotted. In a weld line, stress concentration, disorder of molecular orientation, etc. occur, and therefore the weld line may have low strength. Therefore, from the viewpoint of suppressing a decrease in strength, it is preferable that a weld line does not exist, and even if a weld line exists, it is preferable that the weld line does not penetrate the thickness direction of the passage portion 60.

[0026] However, when the occurrence of the weld line in the passage portion 60 is unavoidable, the influence of the weld line on the strength can be suppressed by positioning the weld line as follows. That is, when the passage portion 60 formed by injection molding is used, the passage portion 60 is overlapped in the sealing region 68 so that the opposing inner surfaces 61 of the passage portion 60 come into contact with each other, and the opposing inner surfaces 61 are bonded to each other to close the passage 62, it is preferable that the weld line 69 is located near the bending portion (bending portion) 67 in the sealing region 68 (see FIG. 4). That is, it is preferable to bend the passage portion 60 along the weld line 69 in the sealing region 68. This can suppress the occurrence of cracks and fissures after the passage 62 is closed, and the freeze resistance of the container 100 can be improved. Therefore, it is preferable that both or either one of the passage portion 60 and the storage portion 20 has a structure that specifies the direction in which the passage portion 60 is overlapped. This allows a person performing the work of closing the passage 62 to easily recognize the direction in which the passage portion 60 is overlapped, and allows the passage portion 60 to be bent along the weld line 69. Note that "the weld line 69 is located near the bent portion 67" means that the weld line 69 is located within a region in a cross section of the passage portion 60 perpendicular to the Z direction, the distance from the bent portion 67 to the cross section being 1 / 20 or less of the outer periphery of the passage portion 60 in the cross section.

[0027] An example of a structure that defines the direction in which the passage parts 60 are stacked is a structure in which the storage part 20 or the passage part 60 has two-fold or less rotational symmetry with respect to an axis parallel to the Z direction. For example, the outer surface 23 of the storage part 20 and / or the outer surface 63 of the passage part 60 may have a cross section perpendicular to the Z direction having two-fold or less rotational symmetry, such as an elliptical shape, at least at any position in the Z direction. In this case, the orientation of the container 100 can be fixed using a fixing member (not shown) that fits with the cross section having two-fold or less rotational symmetry. By fixing the orientation of the container 100 when performing the work of closing the passage 62, the work can be performed easily and stably. An example of such a fixing member is a mounting table having a recess that fits with the bottom of the container 100, i.e., the bottom of the storage part 20. By using a mounting table that fits with the bottom of the container 100 having two-fold or less rotational symmetry, the container 100 can be made to stand on its own.

[0028] 4 shows an example of a top view of the passage 60 as viewed from the Z direction (i.e., as viewed from the third opening 66 side). Based on the shape of the passage 60, the worker can bend the passage 60 at the bent portion 67, overlap the opposing inner surfaces 61d, 61e so that they come into contact with each other, and bond the inner surfaces 61d, 61e to each other. A weld line 69 is located near the bent portion 67.

[0029] The storage section 20 may be provided with an injection needle 80 as shown in Fig. 5. The container 106 shown in Fig. 5 can be used for purposes such as opening the container by puncturing the partition 40, stirring the contents in the storage space 22 or adding additional components to the storage space 22, and then injecting the contents into a patient.

[0030] (2) Manufacturing method of container A method for manufacturing a container according to an embodiment will be described below with reference to FIGS. 6A and 6B, taking as an example a method for manufacturing the container 100 shown in FIG.

[0031] First, as shown in FIG. 6A, a container body 120 and a cover member 160 are prepared.

[0032] The container body 120 has an opening 124. The container body 120 may be a container having any shape, such as a tube, a bottle, or a bag, and any flexibility. When the container body 120 is made of a plastic material, the container body 120 may be formed by, for example, injection molding, but the method of formation is not limited thereto. The content 140 is accommodated in the prepared container body 120.

[0033] The lid member 160 is formed with a lid portion 122, a partition wall 40, and a passage portion 60 having a seal region 68. The partition wall 40 is formed between the lid portion 122 and the passage portion 60. The lid member 160 may be formed from the same material as the container body 120 or a material that can be welded to the container body. This allows the container body 120 and the lid member 160 to be connected without using an adhesive, thereby avoiding contamination by an adhesive. The lid member 160 may be formed by any method, such as injection molding.

[0034] 6B, the container body 120 is covered with the lid member 160 so as to close the opening 124 of the container body 120, and the container body 120 and the lid member 160 are joined by welding or the like. As a result, the storage section 20 is defined by the lid portion 122 of the lid member 160 and the container body 120, and the storage space 22, which is a closed space, is defined within the storage section 20. In this manner, the container 100 according to the embodiment is obtained.

[0035] The container body 120 and the lid member 160 may be joined together via an auxiliary member (not shown). When the container body 120 is a bag-shaped container made of film, the joining of the container body 120 and the lid member 160 becomes easier by using the auxiliary member.

[0036] (3) How to use the container A method of using the container according to the embodiment will be described below. A method of using the container 100 according to the embodiment shown in Fig. 1 will be described below with reference to Figs. 7A to 7C.

[0037] 7A, the partition 40 is punctured with a needle 180 that has passed through the third opening 66, the passage 62, and the second opening 64, thereby connecting the first opening 24 of the storage section 20 and the second opening 64 of the passage section 60 to each other, thereby opening the container 100. Next, a required amount of the content 140 in the storage space 22 is taken out.

[0038] Next, the sealing area 68 of the passage portion 60 is sandwiched by a heat sealer, and the inner surfaces 61 of the passage portion 60 are heated while being in contact with each other. As a result, as shown in Figs. 7B and 7C, a bonding surface 65 is formed where the inner surfaces 61 are bonded. As a result, the passage 62 is blocked, and the accommodation space 22 and the passage 62 become a closed space. That is, the container 100 is resealed. If a weld line is present in the sealing area 68, the weld line may be located in the vicinity of the bending portion (bending portion) 67, i.e., in the vicinity of the end of the bonding surface 65, of the resealed container 100. In addition, in the resealed container 100, "the weld line 69 is located in the vicinity of the bending portion 67 (end of the bonding surface 65)" means that the weld line 69 is located in a region in a cross section perpendicular to the Z direction, the distance from the bending portion 67 (end of the bonding surface 65) is 1 / 20 or less of the outer periphery length of the passage portion 60 in the cross section. A force acts on the adhesive surface 65 in a direction separating the bonded inner surfaces 61, but the force is small near the bent portion 67. Therefore, when a weld line is located near the bent portion 67, the occurrence of cracks or fissures at the weld line after resealing is suppressed, improving the freeze resistance of the container 100. Note that the weld line may be located near each of both ends of the adhesive surface 65, or may be located near only one of the ends of the adhesive surface 65. The passage portion 60 does not need to have a weld line.

[0039] In this manner, the container 100 according to the embodiment can be easily resealed after being opened once while maintaining the punctured state of the septum 40.

[0040] (4) Use of the container The container according to the embodiment is generally used to contain liquids or semi-solid substances such as gels and pastes that require aseptic handling. For example, the container according to the embodiment can be used as a general container related to cells, such as a culture container for culturing cells, a medium supply container for supplying a medium, a cell recovery container for recovering a cell suspension after culture, a waste liquid container for recovering a medium during or after culture, or a temporary cell storage container, or in a cell culture system. In particular, the container can be suitably used in a cell culture system. Other liquids that require aseptic handling include, for example, food-related liquids and pharmaceutical liquids. Food-related liquids include, for example, beverages and seasonings. Examples of pharmaceutical liquids include electrolyte infusions such as physiological saline, carbohydrate injections such as glucose, blood products, antibiotics, protein drugs such as antibodies, peptide drugs such as low molecular weight proteins and hormones, nucleic acid drugs, cellular drugs, vaccines to prevent various infectious diseases, steroids, insulin, anticancer drugs, protease inhibitors, analgesics, antipyretics, analgesics, anti-inflammatory drugs, anesthetics, fat emulsions, blood pressure lowering drugs, vasodilators, electrolyte correction injections such as heparin sodium chloride and potassium lactate, vitamins, contrast media, etc. However, the uses of the container are not limited to these. EXAMPLES

[0041] The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

[0042] (1) Freeze resistance test (1-1) Preparation of test specimen Example 1 A container body with an opening and a lid member with a passage having a sealing area, a partition wall, and a lid portion were produced by injection molding, as shown in FIG. 6A. The thickness of the sealing area was 0.5 mm. A cryopreservation liquid was poured into the container body. Next, as shown in FIG. 6B, the container body and the lid member were joined by welding to obtain a container in which a cryopreservation liquid was contained in a storage space, which is a closed space.

[0043] The partition was punctured with a needle to open the container. The sealing area was then folded along the weld line of the lid member, the sealing area was sandwiched with a heat sealer, and heated at 190°C for 5 seconds. As a result, the inner surfaces of the passage were bonded to form a bonding surface, and the container was sealed again. A weld line was located at the edge of the bonding surface. A test specimen was prepared in this manner. Five test specimens were prepared in the same manner.

[0044] Example 2 Five specimens were prepared in the same manner as in Example 1, except that the container was resealed so that the weld line was located in the center of the adhesive surface.

[0045] Example 3 Five test specimens were prepared in the same manner as in Example 1, except that the thickness of the sealed region was 0.3 mm.

[0046] Example 4 Five test specimens were prepared in the same manner as in Example 2, except that the thickness of the sealed region was 0.3 mm.

[0047] (1-2) Evaluation The test specimens of each Example were placed in the gas phase area of ​​a dry shipper storing liquid nitrogen and frozen for 3 days. The test specimens were then thawed at room temperature and the appearance of the test specimens was confirmed. No cracks or fissures were generated in any of the test specimens of Examples 1 to 3. On the other hand, cracks or fissures were generated in two of the five test specimens of Example 4.

[0048] This result shows that when the seal area is folded along the weld line as in Examples 1 and 3, sufficient freeze resistance is obtained when the thickness of the seal area is 0.5 mm or less, and when the seal area is folded not along the weld line as in Examples 2 and 4, sufficient freeze resistance is obtained when the thickness of the seal area is in the range of more than 0.3 mm and 0.5 mm or less. Therefore, when folding the seal area along the weld line, sufficient freeze resistance can be achieved even if the thickness of the seal area is a small value of 0.3 mm or less. From the viewpoint of further increasing the adhesive strength of the adhesive surface, it is preferable that the thickness of the seal area is smaller. Therefore, it was shown from the examples that folding the seal area along the weld line has the advantage of realizing both improved freeze resistance and adhesive strength.

[0049] (2) Coring generation test Thirty partitions each having a thickness of 320 μm and 180 μm were prepared. Each partition was punctured with a syringe needle (material: SUS316L, inner diameter 0.14 mm) and the occurrence of coring was checked. When the partition thickness was 320 μm, coring occurred in four of the 30 partitions. On the other hand, when the partition thickness was 180 μm, no coring occurred in any of the 30 partitions.

[0050] Although the embodiments of the present invention have been described in detail above, the present invention is not limited to the above-described embodiments, and various design modifications can be made without departing from the spirit of the present invention described in the claims. [Explanation of symbols]

[0051] 20 Storage unit 21 Inner surface 21a Vertical plane 21b Slope 22 Containment Space 23 Outer surface 24 First Opening 40 Bulkhead 60 Passage section 61 Inner surface 61a Slope Aisle 62 63 External surface 64 Second Opening 65 Adhesive surface 66 Third Opening 67 Bending section 68 Sealing Area 69 Weld Line 80 Syringe needle 100, 102, 104, 106 containers 120 Container body 122 Lid 140 Contents 160 Lid member 180 needles

Claims

1. a container defining a container space in which a liquid or semi-solid substance is contained and a first opening communicating with the container space; a punctured septum provided at the first opening; a second opening connected to the first opening and a passage portion defining a passage communicating with the second opening; A container comprising: the passage portion has a seal area that closes the passage, In the sealing region, the passage portion is bent so that opposing inner surfaces of the passage portion come into contact with each other, and the opposing inner surfaces are bonded to each other; The container, wherein the passage portion includes a weld line, and the passage portion is folded along the weld line in the seal area.

2. 2. The container of claim 1, wherein the passage has a thickness in the seal area of ​​more than 300 μm and not more than 500 μm.

3. 3. The container of claim 1, wherein the passageway has a uniform thickness in the sealing area.

4. The container according to claim 1 or 2, wherein the passage portion has a region in the sealing region where the thickness increases toward the second opening.

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