Injection preparation kit and injection preparation system including the same

Abstract

The disclosed invention is an injection dispensing kit comprising: a cylinder cartridge that allows external fluid to flow in and out through changes in cylinder volume caused by the relative fixing and rotation of a pair of pistons installed inside; a first tube connected to an outlet pipe of the cylinder cartridge; a three-way valve that selectively connects one of two inlet passages to an outlet passage; a second tube that connects the outlet passage of the three-way valve to the inlet pipe of the cylinder cartridge; a third tube connected to the first inlet passage of the three-way valve; and a fourth tube connected to the second inlet passage of the three-way valve.

Description

[Technical field]

[0001] The present invention relates to an injection preparation kit and an injection preparation system including the same, and more particularly to an injection preparation kit and injection preparation system that are configured as a closed system that can minimize contamination from the external environment and can safely and accurately prepare and even administer injections by reducing the workload and errors of an operator. [Background technology]

[0002] In the medical field, it is common to inject blood, Ringer's solution, amino acid solution, glucose solution or medicines into a patient's body as a form of replacement therapy, deficiency correction or treatment therapy in the case of illness, accident, or excessive bleeding during surgery, or when the patient is ill due to infection or weakened immunity, or when there is a lack of fluid, electrolytes or nutrients in the body.

[0003] Syringe pumps and infusion pumps are used to inject injections such as blood and medicines (hereinafter referred to as "injections") into patients at the exact amount and speed prescribed by a doctor. A syringe pump injects the injection by pushing the plunger of a syringe to apply pressure to the injection inside, while an infusion pump injects the injection by squeezing the infusion tube of a liquid medicine container hung at a height where appropriate gravity acts on the patient. In other words, syringe pumps and infusion pumps are used depending on the shape and type of sterile sealed container the injection is in, and the injection amount, speed, and time are administered as prescribed by accurately controlling the motor to push the plunger in the syringe pump and repeatedly press the infusion tube in the infusion pump.

[0004] Meanwhile, injections often contain toxic drugs such as anticancer drugs and contrast media. Anticancer drugs must be handled by specialized pharmacists in a sterile dispensing room, who must wash their hands thoroughly before entering the room and wear personal protective equipment such as antibacterial clothing, antibacterial shoes, masks, hair caps, protective gloves, and protective glasses. In addition, even in the sterile dispensing room, the surrounding environment such as work tables must be disinfected, prescriptions for drugs handled must be accurately checked, and syringes, needles, and ampoules must be disinfected before use and disposed of in the specified manner. In addition, injections prepared in the sterile dispensing room must be kept sterile and the seal must be removed just before administration to the patient to minimize contamination issues.

[0005] Thus, the procedures for handling toxic drugs such as anticancer drugs are very complicated and strict, and even highly trained pharmacists always face difficulties and risks when handling toxic substances directly. In addition, if several toxic drugs are mixed into one pack, complicated procedures must be repeated, and in such cases, there is a high possibility of errors or mistakes in the dosage. In particular, it is difficult for specialized pharmacists surrounded by various personal protective equipment to maintain concentration for long periods of time, so placing the responsibility for dispensing toxic drugs solely on specialized pharmacists is an excessive burden.

[0006] In the past, an automated dispensing robot that mixes cytotoxic intravenous injections was introduced as a solution to these problems. The automated dispensing robot is equipped with an articulated robot arm inside a space that maintains a sterile environment, and automatically carries out a series of processes, from sorting and identifying drugs through barcode scanning based on prescription data, extracting the drugs with a syringe, and injecting them into the drug container to be dispensed. In other words, the articulated robot arm directly replaces the role of a traditional specialized pharmacist.

[0007] However, because the price of the equipment itself was extremely high compared to its operating rate, only a few units were sold, primarily to large, well-capitalized hospitals. As a result, there were clear limitations to its widespread use in frontline medical settings, where the number of anti-cancer drug dispensing cases alone exceeds hundreds of thousands per year. [Prior art documents] [Patent documents]

[0008] [Patent Document 1] Korean Patent No. 10-0948632 Summary of the Invention [Problem to be solved by the invention]

[0009] The present invention aims to provide an injection preparation kit and an injection preparation system including the same that can inexpensively, safely, hygienically, and simply prepare injections that combine various drugs, particularly injections that must be carefully controlled under strictly restricted conditions because they contain toxic anticancer drugs and contrast agents. [Means for solving the problem]

[0010] The injection preparation kit according to the present invention includes a cylinder cartridge that introduces and discharges an external fluid through a change in cylinder volume caused by the relative fixing and rotating of a pair of pistons provided inside, a first tube connected to an outlet pipe of the cylinder cartridge, a three-way valve that selectively connects one of two inlet passages to an outlet passage, a second tube connecting the outlet passage of the three-way valve to the inlet pipe of the cylinder cartridge, a third tube connected to the first inlet passage of the three-way valve, and a fourth tube connected to the second inlet passage of the three-way valve.

[0011] Here, an infusion pack is connected to the first tube and the third tube, and a drug container is connected to the fourth tube.

[0012] It is preferable that the fourth tube and the drug container are connected by an adaptor with an air inlet function.

[0013] The present invention may further include at least one or more additional three-way valves, and a first inlet flow path and an outlet flow path of the additional three-way valve may be connected to any one of the second to fourth tubes, in which case an additional drug container is connected to a second inlet flow path of the additional three-way valve.

[0014] Alternatively, an infusion pack may be connected to the second inlet flow path of the additional three-way valve, empty infusion packs may be connected to the first tube and the third tube, and a drug container may be connected to the fourth tube.

[0015] The cylinder cartridge includes an upper rotor and a lower rotor that are rotatable relative to each other, and an annular cylindrical space is formed between the upper rotor and the lower rotor. A first piston of the pair of pistons is coupled to the upper rotor and can rotate along the cylindrical space, and a second piston is coupled to the lower rotor and can rotate along the cylindrical space.

[0016] The present invention also provides an injection preparation system including an injection preparation kit having the above-described configuration, and a cylinder pump to which the cylinder cartridge of the injection preparation kit is attached and which independently drives a pair of pistons provided inside the cylinder cartridge.

[0017] The cylinder pump includes a cylinder driving unit that independently drives a pair of pistons provided in the cylinder cartridge, and a control unit that controls the cylinder driving unit, and the control unit controls the amount and speed of liquid flowing in and out of the cylinder cartridge to preset values.

[0018] In addition, the control unit controls the cylinder driving unit so that a predetermined amount of medicinal liquid in the medicine container connected to the fourth tube flows in and flows out into the infusion pack connected to the first tube.

[0019] Here, the three-way valve has a second inflow passage connected to the fourth tube and an outflow passage connected to the second tube in an open state.

[0020] The cylinder driving unit may include a first driving unit that drives an upper rotating body of the cylinder cartridge and a second driving unit that drives a lower rotating body, and may have a dual shaft structure in which the second driving shaft of the second driving unit is inserted into the first driving shaft of the first driving unit.

[0021] According to an embodiment of the present invention, the first driving part and the second driving part are each a worm gear structure.

[0022] On the other hand, the present invention provides a method for preparing an injection preparation kit having the above-mentioned configuration, comprising: a first step of connecting an infusion pack to the first tube and the third tube and connecting a drug container to the fourth tube; a second step of attaching a cylinder cartridge of the injection preparation kit to a cylinder pump that independently drives a pair of pistons provided inside the cylinder cartridge; a third step of inputting an amount of drug liquid in the drug container to be introduced into the infusion pack to the cylinder pump; a fourth step of opening a second inflow flow path connected to the fourth tube and an outflow flow path connected to the second tube in the three-way valve; and a fifth step of driving the cylinder pump to introduce a set amount of drug liquid in the drug container into the infusion pack.

[0023] Furthermore, after the fifth step, the three-way valve is operated to form a circulation flow path for the infusion liquid by opening the first inflow flow path connected to the third tube and the outflow flow path connected to the second tube, and the cylinder pump is operated to circulate the infusion liquid in the infusion pack through the cylinder cartridge, so that any medicinal liquid remaining in the tube can be taken into the infusion pack.

[0024] The method may further include a priming step between the third step and the fourth step, in which the priming step removes air from within the first to third tubes, and the priming step opens a first inflow passage connected to the third tube and an outflow passage connected to the second tube of the three-way valve, and circulates the infusion solution in the infusion pack through the cylinder cartridge to remove air from within the first to third tubes.

[0025] Depending on the embodiment, a step of replacing the drug container with another additional drug container and driving the cylinder pump to introduce a set amount of the medicinal liquid in the additional drug container into the infusion pack can be performed.

[0026] Alternatively, the first step may include a 1-1 step of connecting a first inlet flow path and an outlet flow path of at least one or more additional three-way valves to any one of the second to fourth tubes, and connecting an additional drug container to the second inlet flow path of the additional three-way valve, and after the fifth step, may include a further mixing step of closing the outlet flow path to the drug container and opening the outlet flow path to the additional drug container, and driving the cylinder pump to introduce a set amount of drug liquid in the additional drug container into the infusion pack.

[0027] On the other hand, the first step includes a 1-1 step of connecting an empty infusion pack to the first tube and the third tube, connecting a first inflow flow path and an outflow flow path of at least one or more additional three-way valves to any one of the second to fourth tubes, and connecting an infusion pack to the second inflow flow path of any one of the additional three-way valves, and the third to fifth steps include a 1-1 step of taking in a set amount of infusion from the infusion pack connected to the second inflow flow path of the additional three-way valve into the empty infusion pack, and then closing the outflow flow path of the infusion pack and opening the outflow flow path to the drug container to take in a set amount of the drug liquid in the drug container into the empty infusion pack.

[0028] Then, after the fifth step, a finishing step may be added to the cylinder cartridge, in which the drug container and the fourth tube are removed and the second inlet flow path of the three-way valve is closed, or the drug container, the fourth tube and the second tube are removed and the third tube is connected to an inlet pipe.

[0029] In addition, the injection preparation kit according to the present invention can also be used for dissolving powdered medicine. In this case, the injection preparation kit includes a first tube connected to the outlet tube of the cylinder cartridge, a powdered medicine container connected to the first tube, a second tube connected to the inlet tube of the cylinder cartridge, and a diluent pack connected to the second tube.

[0030] The present invention also provides a method for dispensing injections, comprising: a first step of preparing an injection preparation kit for powdered medicines as described above; a second step of mounting a cylinder cartridge of the injection preparation kit on a cylinder pump which independently drives a pair of pistons provided inside the cylinder cartridge; a third step of inputting to the cylinder pump an amount of diluent in the diluent pack to be introduced into the powdered medicine container; and a fourth step of driving the cylinder pump to introduce a set amount of diluent in the diluent pack into the powdered medicine container. Effect of the Invention

[0031] When the injection preparation kit of the present invention having the above-mentioned configuration is used, the cylinder pump performs both the suction and discharge operations together, so that the operations of a conventional syringe can be performed automatically. This reduces the need for manual intervention, greatly reducing the risk of handling toxic medicinal liquids, and the risk of errors during preparation is also eliminated by automatically measuring accurate amounts.

[0032] In addition, according to the above-mentioned conventional technology, there is a moment when the injection is exposed to the external environment during the preparation process, which may lead to contamination or infection. However, in the present invention, all preparation processes are carried out while the injection preparation kit maintains a closed system, so there is no need to insert and remove the injection needle as in the conventional technology. This has the advantage of reducing the risk of contamination of the infusion pack. [Brief description of the drawings]

[0033] [Figure 1] FIG. 1 is a diagram showing the overall configuration of a cylinder pump, which is a prior patent of the applicant. [Diagram 2] FIG. 2 is an exploded perspective view of a cylinder cartridge mounted in the cylinder pump of FIG. 1. [Diagram 3] FIG. 2 is a diagram showing a state in which a cylinder cartridge is attached to the cylinder pump of FIG. 1. [Figure 4]FIG. 2 is a diagram of a cylinder driving unit provided in the cylinder pump of FIG. 1. [Diagram 5] FIG. 5 is an exploded perspective view of the cylinder drive unit of FIG. 4. [Figure 6] FIG. 2 is a diagram showing the intake and exhaust processes performed in a cylinder cartridge. [Figure 7] FIG. 1 shows one embodiment of an injection preparation kit according to the present invention. [Figure 8] FIG. 8 is a diagram showing the injection preparation kit of FIG. 7 in which the flow path of the three-way valve is changed. [Figure 9] FIG. 13 shows another embodiment of the injection preparation kit according to the present invention. [Figure 10] FIG. 13 shows another embodiment of the injection preparation kit according to the present invention. [Figure 11] FIG. 8 is a diagram showing one embodiment of an injection preparation system in which the injection preparation kit of FIG. 7 is coupled to a cylinder pump. [Figure 12] This is a diagram showing the state in which finishing work has been performed on the infusion pack after the injection has been prepared. [Figure 13] 13 is a diagram showing another state in which finishing work has been performed on the infusion pack after the injection has been prepared. FIG. [Figure 14] FIG. 13 shows a modified embodiment of the injection preparation kit according to the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0034] Since the present invention can be modified in various ways and has various embodiments, specific embodiments are illustrated and described in detail in the detailed description. However, this is not intended to limit the present invention to the specific embodiments, and it should be understood that the present invention includes all modifications, equivalents, and alternatives within the spirit and technical scope of the present invention.

[0035] The terms used in the present invention are merely used to describe specific embodiments and are not intended to limit the present invention. A singular expression includes a plural expression unless otherwise clearly indicated in the context. In the present invention, the terms "include" or "comprise" are intended to specify the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, and should be understood not to preclude the presence or additional possibility of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0036] Hereinafter, a preferred embodiment of the present invention will be described in detail with reference to the attached drawings. At this time, it should be noted that in the attached drawings, the same components are denoted by the same reference numerals as much as possible. Also, detailed description of known functions and configurations that are not the gist of the present invention will be omitted. For the same reason, some components are exaggerated or omitted or illustrated roughly in the attached drawings.

[0037] The present invention relates to an injection preparation kit 10 and an injection preparation system 1000 including the same, and is characterized in that the injection preparation kit 10 is constructed as a closed system, thereby minimizing contamination from the external environment, reducing the workload and errors of the operator, and safely and accurately preparing an injection, and the prepared injection preparation kit 10 can be immediately administered to a patient. Here, in order to explain the injection preparation kit 10 of the present invention, it is necessary to explain the cylinder pump 500, which is a prior patent application of the applicant. However, the configuration of the cylinder pump 500 will be briefly described within the scope necessary for understanding the present invention.

[0038] FIG. 1 is a diagram showing the overall appearance of the cylinder pump 500 of the prior patent application, with the front cover 510 open. When the front cover 510 is opened, the cylinder cartridge 100 shown in FIG. 2 can be coupled, and FIG. 3b shows the state in which the cylinder cartridge 100 is coupled in the cylinder pump 500. Incidentally, the cylinder cartridge 100 is fixed by an auto-lock function so that the cylinder cartridge 100 coupled with the drive shaft 522 is fixed so as not to move during operation. The cylinder cartridge 100 and its drive unit 520, as well as the operating principle, will be described below.

[0039] 2, the cylinder cartridge 100 has a structure in which an upper housing 110 and a lower housing 120 are hermetically coupled to form a single housing, in which an upper rotating body 114 and a lower rotating body 122 are aligned on the same axis so that they can rotate independently. The upper rotating body 114 and the lower rotating body 122 each have a truncated cone shape, and the apexes of the truncated cones (the apexes of the extended generatrix) are arranged to face each other, forming a recessed space between the housing and the upper rotating body 114 and the lower rotating body 122. This annular space is used as the cylinder space 130.

[0040] Upper and lower fastening members 118 and 126 are integrally formed on the inclined surfaces of the upper and lower rotating bodies 114 and 122, respectively, and a first piston 140 is coupled to the upper fastening member 118, and a second piston 142 is coupled to the lower fastening member 126. The first piston 140 and the second piston 142 are made of a material that is elastic and deformable so as to closely adhere to the surrounding surface, like a rubber packing coupled to the end of a plunger of a general syringe. That is, the first piston 140 and the second piston 142 are in close contact with the inner circumferential surface of the housing, and a negative pressure and a positive pressure can be partially formed in the annular cylinder space 130 by the rotational movement of the first piston 140 or the second piston 142. Incidentally, the annular member not indicated with a reference symbol in FIG. 2 is a sealing member for sealing.

[0041] The lower housing 120 is provided with an inflow pipe 150 and an outflow pipe 152, and an infusion tube is fitted into the inflow pipe 150 and the outflow pipe 152, respectively. A drive shaft insertion hole 112 is formed in the center of the upper housing 110, and a first drive shaft fastening hole 116 is formed in the upper rotating body 114 coaxially with the drive shaft insertion hole 112, and a second drive shaft fastening hole 124 is formed in the lower rotating body 122. Here, the first drive shaft fastening hole 116 is larger than the second drive shaft fastening hole 124. In other words, it is possible to approach the second drive shaft fastening hole 124 through the first drive shaft fastening hole 116. The first drive shaft fastening hole 116 and the second drive shaft fastening hole 124 are shaped to have a directional property. In the illustrated embodiment, the first drive shaft fastening hole 116 is cross-shaped with varying widths and the second drive shaft fastening hole 124 is T-shaped.

[0042] 3a, a drive shaft 522 is present in the center of the cartridge mounting groove 512, and a cylinder drive unit 520 disposed in the body of the cylinder pump 500 is shown in Figs. 4 and 5. The cylinder drive unit 520 is provided with two drive motors, and a first drive shaft 538 and a second drive shaft 548 operated independently by each drive motor have a double-shaft structure in which the second drive shaft 548 is contained within the first drive shaft 538 with the same rotation axis, and thus form a single drive shaft 522 in appearance.

[0043] FIG. 5 is an exploded perspective view of the cylinder driving unit 520. The first and second driving units 530 and 540 are each configured with a worm gear structure. The first driving unit 530 includes a first driving motor 532, a first worm 534 coupled to the shaft of the first driving motor 532, and a first worm gear 536 meshing with the first worm 534, and the first driving shaft 538 extends in a direction perpendicular to the gear of the first worm gear 536. The second driving unit 540 also includes a second driving motor 542, a second worm 544, a second worm gear 546, and a second driving shaft 548 having a similar structure.

[0044] In particular, the cylinder driver 520 in FIG. 5 has a double-shaft structure in which the second drive shaft 548 is inserted into the first drive shaft 538. That is, the first drive shaft 538 is a hollow shaft into which the second drive shaft 548 is inserted and then protrudes. Even with this double-shaft structure, the first and second drive parts 530, 540 have a worm gear structure, so that even if either the first drive shaft 538 or the second drive shaft 548 rotates, the other drive shaft cannot be rotated. Therefore, the first drive shaft 538 and the second drive shaft 548 operate independently.

[0045] 2, 4 and 5, the outer surface of the first drive shaft 538 corresponds to the shape of the first drive shaft fastening hole 116 formed in the upper rotating body 114 of the cylinder cartridge 100, and the end of the second drive shaft 548 corresponds to the shape of the second drive shaft fastening hole 124 formed in the lower rotating body 122. The first drive shaft fastening hole 116 is larger than the second drive shaft fastening hole 124, and the second drive shaft 548 protrudes further than the first drive shaft 538. Therefore, when the cylinder cartridge 100 is mounted in the cartridge mounting groove 512, the second drive shaft 548 passes through the first drive shaft fastening hole 116 through the drive shaft insertion hole 112 of the cylinder cartridge 100 and is fastened to the second drive shaft fastening hole 124 of the lower rotating body 122 located further inward, and the first drive shaft 538 is fastened to the first drive shaft fastening hole 116. Since the first drive shaft 538 and the second drive shaft 548 operate independently, the first piston 140 connected to the upper rotating body 114 by the first drive unit 530 can rotate independently, and the second piston 142 connected to the lower rotating body 122 can also rotate independently by the second drive unit 540.

[0046] The operating principle of the cylinder pump 500 having such a structure shown in FIGS. 1 to 5 is shown in FIG.

[0047] The cylinder pump 500 according to the prior patent application controls the rotational movement of the first piston 140 and the second piston 142 of the cylinder cartridge 100 by the operation of the driving unit 520, so that the injection material (blood, medicinal liquid, etc.) flows out through the cylinder cartridge 100 to the outside, that is, is injected into the patient. The intake and discharge of the injection material consists of an infusion cycle and an alternation cycle.

[0048] For example, when the cylinder pump 500 is initially driven, the control unit of the cylinder pump 500 fixes the second piston 142 at a point between the inlet pipe 150 and the outlet pipe 152 as shown in Fig. 6a in order to control the injection stroke, and the first piston 140 located on the inlet pipe 150 side rotates counterclockwise to form a negative pressure in the cylinder space 130 between the first piston 140 and the second piston 142. Due to this negative pressure, the injection agent flows into the cylinder cartridge 100 through the inlet pipe 150.

[0049] Then, as the first piston 140 continues to rotate counterclockwise as shown in Figures 6b and 6c, the injection agent flows into the inside of the cylinder through the inflow pipe 150, and the injection agent in the cylinder flows out of the cylinder cartridge 100 through the outflow pipe 152. The movement (inflow and outflow) of the injection agent is continued.

[0050] Thereafter, if the first piston 140 rotates and is positioned at the outlet pipe 152 as shown in Fig. 6d, the injection agent in the cylinder does not flow out, but at this point, the control unit simultaneously drives the first piston 140 and the second piston 142 to position the first piston 140 between the inlet pipe 150 and the outlet pipe 152 where the second piston 142 was previously positioned as shown in Fig. 6e, and controls the second piston 142 to rotate in a counterclockwise direction. That is, an alternating stroke control is performed in which the first piston 140 and the second piston 142 change their roles (fixed and rotating).

[0051] After this alternating stroke control is performed, the injection stroke control is performed again in which the second piston 142 rotates counterclockwise as shown in Figures 6f and 6g while the first piston 140 is fixed. Of course, when the second piston 142 rotates to the outlet pipe 152 as shown in Figure 6h, the alternating stroke control is performed again and the roles of the first piston 140 and the second piston 142 are switched.

[0052] The inflow and outflow of the injection agent by the injection stroke performed by the first and second pistons 140 and 142 corresponds to the volume of the cylinder corresponding to the rotation angle of the rotating piston. Therefore, by controlling the rotation speed and rotation angle of the first driving motor 532 and the second driving motor 542, the injection speed and injection amount of the injection agent discharged by the cylinder pump 500 can be accurately maintained (for example, the first driving motor 532 and the second driving motor 542 can be configured with an encoder motor). In other words, the above-mentioned cylinder pump 500 can accurately control the flow rate and flow speed of the injection agent passing through the cylinder cartridge 100 according to the set value, which means that the cylinder pump 500 of the prior patent application has a bolus function that accurately injects the injection agent into the patient at the set injection speed and injection amount.

[0053] Such a cylinder pump 500 can perform the bolus function accurately, and has several other advantages. One of them is that the cylinder cartridge 100 constitutes a closed system independent of the cylinder pump 500. In other words, if an infusion tube and an injection pack are connected to the inlet pipe 150 and the outlet pipe 152 with the cylinder cartridge 100 at the center, it can be attached to any cylinder pump 500 and used. This means that if the cylinder cartridge 100, an infusion set, and various drugs such as anticancer drugs are combined in a kit form to prepare an injection, it can be used at any time, and problems such as contamination and infection are basically improved.

[0054] Another advantage is that the cylinder pump 500 is operated by the rotation of the first and second pistons 140, 142 in the cylinder cartridge 100. Therefore, unlike conventional syringe pumps, there is no need to change syringes even when used for a long period of time (several days or more) on one patient, and unlike infusion pumps, there is no need to periodically adjust the position where the infusion tube is pushed to avoid fluctuations in the amount of injection due to deformation of the infusion tube, so it can be used continuously for a very long time, which is a major advantage.

[0055] The injection preparation kit 10 according to the present invention and the injection preparation system 1000 including the same are derived from the fact that the cylinder pump 500 developed by the applicant actively sucks in and expels the injection, enabling highly accurate bolus control, and the unique configuration in which the cylinder cartridge 100 constitutes an independent closed system. Figure 7 shows one embodiment of the injection preparation kit 10 according to the present invention.

[0056] 7, the injection preparation kit 10 according to the present invention is configured by connecting several tubes and a three-way valve 200 to a cylinder cartridge 100, to which an infusion pack 400 and a medicine container 410 for mixing with the infusion liquid in the infusion pack 400 are combined. Using this injection preparation kit 10, the prescribed amount of medicine is accurately mixed in the infusion pack 400 (or a nutritional pack, etc. are also possible, and will be referred to as an infusion pack only representatively) to prepare an injection. In addition, most of the tubes included in the injection preparation kit 10 can be made of a transparent material, typically an infusion tube, which allows the flow of the infusion liquid and the medicine to be confirmed.

[0057] The injection preparation kit 10 includes a cylinder cartridge 100 that allows external fluid to flow in and out through a change in cylinder volume caused by the relative fixed and rotating motion of a pair of pistons 140, 142 installed inside. The configuration of the cylinder cartridge 100 is the same as that described above.

[0058] In addition, a first tube 310 is connected to the outlet pipe 152 of the cylinder cartridge 100, and an outlet passage 206 of the three-way valve 200 is connected to the inlet pipe 150 of the cylinder cartridge 100 via a second tube 320. The three-way valve 200 selectively opens or closes the flows of the two passages by connecting only one of the two inlet passages to the outlet passage 206. A third tube 330 is connected to the first inlet passage 202 of the three-way valve 200, and a fourth tube 340 is connected to the second inlet passage 204.

[0059] According to the configuration of the injection preparation kit 10, liquid flows in one direction through the first tube 310 in the outlet pipe 152 of the cylinder cartridge 100, but only one of the third tube 330 and the fourth tube 340 is selectively introduced into the inlet pipe 150 of the cylinder cartridge 100 by the operation of the three-way valve 200. That is, two types of liquids selectively flow into the inlet pipe 150 of the cylinder cartridge 100, and the selected one of the flows is discharged through the outlet pipe 152.

[0060] In the injection preparation kit 10 of the present invention, in order to prepare an injection by accurately mixing the infusion in the infusion pack 400 with a prescribed amount of medicinal liquid such as an anticancer drug, the infusion pack 400 is connected to the first tube 310 and the third tube 330, and the medicine container 410 is connected to the fourth tube 340. As a result, the infusion in the infusion pack 400 or the medicinal liquid in the medicine container 410 flows selectively through the inflow pipe 150 of the cylinder cartridge 100. As described below, the infusion flows into and out of the infusion pack 400, but the medicinal liquid flows only out of the medicine container 410, so that the negative pressure in the medicine container 410 needs to be eliminated in order to smoothly discharge the medicinal liquid. For this reason, it is preferable to connect the fourth tube 340 and the medicine container 410 with an adapter 300 with an air inflow function. Moreover, it is more preferable that the adapter 300 has a function as a holder for the drug container 410, thereby preventing the risk of the drug container 410 being removed without the user's knowledge.

[0061] 9, an additional flow path may be configured to mix two or more drug solutions in sequence. The additional flow path includes a three-way valve 200, and the configuration of the additional flow path may be expanded by the number of additional drug containers 420. The first inflow flow path and the outflow flow path of the additional three-way valve 210 are connected to one of the second to fourth tubes 320, 330, and 340, and the additional drug container 420 is connected to the second inflow flow path of the additional three-way valve 210. As a result, each drug container 410 is arranged in parallel with the inflow pipe 150 of the cylinder cartridge 100.

[0062] Another embodiment having the same basic structure as that of Fig. 9 can be constituted by the injection preparation kit 10 of Fig. 10. The embodiment of Fig. 10 is characterized in that an empty infusion pack 402 is prepared, and an infusion and a drug such as an anticancer drug are sequentially introduced into this empty infusion pack 402 to complete an injection. That is, the above-mentioned embodiment introduces a fixed amount of drug into an infusion pack 400 containing an infusion and mixes them, whereas the embodiment of Fig. 10 differs in that not only the drug but also the infusion is discharged at a fixed amount via a cylinder pump 500 to prepare an injection.

[0063] Specifically, an infusion pack 400 is connected to the second inflow flow path of the additional three-way valve 210, an empty infusion pack 402 is connected to the first tube 310 and the third tube 330, and a drug container 410 is connected to the fourth tube 340. When preparing an injection, the outflow flow path of the additional three-way valve 210 is opened to introduce the infusion liquid of the infusion pack 400 into the empty infusion pack 402 in the amount specified by the prescription, and then the drug liquid of the drug container 410 connected to the three-way valve 200 is introduced into the empty infusion pack 402 (in this state, a fixed amount of infusion liquid has been introduced, but in order to distinguish it from an infusion pack, the same term will be used hereafter) in the same amount as specified by the prescription to complete the injection.

[0064] The embodiment of Fig. 10 has an advantage in that it is possible to dispense an injection according to a prescription without having to previously drain and discard an excess amount of infusion liquid over the prescribed amount from the infusion pack 400 (a precise amount can be drained using a cylinder pump). It goes without saying that the embodiment of Fig. 10 can also mix multiple medicinal liquids as in Fig. 9 by further including an additional three-way valve 210 and an additional drug container 420.

[0065] 11 shows an injection preparation system 1000 configured by mounting an injection preparation kit 10 to a cylinder pump 500. The injection preparation kit 10 is completed as a single kit by configuring an infusion pack 400 and a drug container 410 in a closed system centered around a cylinder cartridge 100, and the injection preparation system 1000 can be said to be a system that can accurately prepare injections according to a prescription using the bolus function of the cylinder pump 500.

[0066] The injection preparation kit 10 is a completed kit in itself, and all preparations for injection preparation are completed simply by placing the cylinder cartridge 100 of the injection preparation kit 10 in the cartridge mounting groove 512 of the cylinder pump 500. The configuration in which the cylinder driving unit 520 of the cylinder pump 500 operates the cylinder cartridge 100 is the same as that described above.

[0067] The cylinder pump 500 includes a control unit that controls the cylinder driving unit 520, and the control unit can accurately control the amount and speed of the liquid flowing in and out of the cylinder cartridge 100 to a preset value. The process of mixing one medicinal liquid into the infusion pack 400 without an additional medicinal container 420 is the simplest yet fundamental process, and it is only necessary to repeat this process for additional medicinal liquids.

[0068] 7, the three-way valve 200 has the second inflow passage 204 connected to the fourth tube 340 and the outflow passage 206 connected to the second tube 320 in an open state. Therefore, the medicinal liquid in the medicinal container 410 can flow through the inflow pipe 150 of the cylinder cartridge 100, and the flow of infusion liquid through the third tube 330 is blocked. In this state, the control unit of the cylinder pump 500 controls the cylinder driving unit 520 to suck in a preset amount of medicinal liquid from the medicinal container 410 connected to the fourth tube 340 and discharge it into the infusion pack 400 connected to the first tube 310.

[0069] That is, in the past, a specialized pharmacist dispensed an injection by extracting the liquid medicine from a medicine container (such as an ampule) with a syringe and injecting it into an infusion pack 400, but in the present invention, the cylinder pump 500 performs two actions of intake and exhaust together, so that it automatically performs the same work as a conventional syringe. This reduces the need for human intervention, greatly reducing the risk of handling toxic liquid medicine, and automatically measures the exact amount of medicine such as anticancer drugs when prescribing and dispensing, eliminating the risk of mistakes when dispensing.

[0070] In addition, since all preparation processes are performed while the injection preparation kit 10 maintains a closed system in the present invention, there is no need to insert and remove the injection needle as in the past, which has the advantage of reducing the risk of contamination of the infusion pack 400. Here, in order to ensure the closed nature of the injection preparation kit 10, it is recommended that needleless valves that automatically switch to a locked state when removed be applied to the connecting parts of various tubes.

[0071] The process of dispensing an injection according to a prescription using the injection dispensing kit 10, the cylinder pump 500, and the adapter 300 with air inflow function according to the present invention will be described below. Here, the cylinder pump 500 is omitted from the drawings referred to for the explanation of the injection dispensing process, but this is omitted for the convenience of explanation, and it should be understood that the cylinder pump 500 is naturally used to operate the cylinder cartridge 100. Moreover, the injection dispensing process is carried out in a sterile facility.

[0072] First, the injection preparation kit 10 as shown in Fig. 7 is prepared, and the infusion pack 400 is connected to the first tube 310 and the third tube 330, and the medicine container 410 is connected to the fourth tube 340. Of course, the infusion and medicine to be used are according to the doctor's prescription. Then, the cylinder cartridge 100 of the injection preparation kit 10, which has been sterilized and packaged, is coupled to the cartridge mounting groove 512 of the cylinder pump 500. As a result, a pair of pistons 140, 142 provided inside the cylinder cartridge 100 can be independently driven by the cylinder driving unit 520 of the cylinder pump 500.

[0073] After the installation of the injection preparation kit 10 is completed, the dispenser (professional pharmacist) checks the dosage of the prepared medicinal liquid indicated in the prescription, and then inputs the amount of the medicine to be introduced into the infusion pack 400 to the control unit of the cylinder pump 500. In this case, the three-way valve 200 must be operated to open the second inflow flow path 204 connected to the fourth tube 340 and the outflow flow path 206 connected to the second tube 320.

[0074] Once all of these preparations are complete, the cylinder pump 500 is driven to draw a set amount of medicinal liquid from the medicine container 410 into the infusion pack 400, and once the set amount of medicinal liquid has flowed, the cylinder pump 500 stops operating.

[0075] The above process is the basis for dispensing an injection. In addition, it is possible that the entire amount of the medicinal liquid is not introduced into the infusion pack and remains in the first tube 310 and the second tube 320. In order to inject all of the remaining medicinal liquid into the infusion pack 400, a process of circulating the infusion liquid in the infusion pack 400 is involved. That is, the three-way valve 200 is operated to open the first inflow flow path 202 connected to the third tube 330 and the outflow flow path 206 connected to the second tube 320 to form a circulation flow path for the infusion liquid, and then the cylinder pump 500 is operated to circulate the infusion liquid in the infusion pack 400 through the cylinder cartridge 100, and all of the medicinal liquid remaining in the tubes is introduced into the infusion pack 400.

[0076] The above description is of a method in which the medicinal liquid in the medicinal container 410 is first sucked in and then discharged out, but a priming step of removing air from the first to third tubes 310, 320, and 330 may be further included prior to this. The priming step is similar to the process of circulating the infusion liquid in the infusion pack 400 described above, and is shown in FIG. 8. The three-way valve 200 is in a state in which the first inflow flow path 202 connected to the third tube 330 and the outflow flow path 206 connected to the second tube 320 are open, and the infusion liquid in the infusion pack 400 is circulated through the cylinder cartridge 100 to remove air from the first to third tubes 330.

[0077] In addition, although the above description has been given on the basis of mixing one medicinal liquid, it is of course possible to mix two or more medicinal liquids in one infusion pack 400.

[0078] For example, the drug container 410 from which the drug liquid has been extracted can be replaced with another additional drug container 420, and thereafter, the prescribed dose for the additional drug container 420 can be input and the set amount of drug liquid in the additional drug container 420 can be introduced into the infusion pack 400. This process can be repeated for the number of types of drug liquid prescribed.

[0079] However, the process of repeatedly connecting and disconnecting a plurality of drug containers 410 to one ampoule adapter 300 is undesirable in terms of contamination. Therefore, by configuring the injection drug dispensing kit 10 of the present invention as shown in Fig. 9, the extraction process can be performed sequentially on the two drug containers 410, 420 without a replacement process.

[0080] That is, a first inflow flow path and an outflow flow path of at least one additional three-way valve 210 are connected to one of the second to fourth tubes 320, 330, 340 (shown as the second tube in FIG. 9), and an additional drug container 420 is connected to the second inflow flow path of the additional three-way valve 210, thereby preparing a completed injection preparation kit 10. After that, when the extraction process for the drug container 410 is completed, the outflow flow path 206 for the drug container 410 is closed and the outflow flow path for the additional drug container 420 is opened, and the cylinder pump 500 is driven to introduce a set amount of the drug solution in the additional drug container 420 into the infusion pack 400, thereby completing a series of injection preparation processes.

[0081] Also, as described in the embodiment of FIG. 10, an injection can be prepared using an empty infusion pack 402. That is, the injection preparation kit 10 is configured by connecting an empty infusion pack 402 to the first tube 310 and the third tube 330, connecting the first inflow flow path and the outflow flow path of at least one additional 3-way valve 210 to any one of the second to fourth tubes 320, 330, and 340, and connecting the infusion pack 400 to the second inflow flow path of any one of the additional 3-way valves 210. The drug container 410 is connected to the second inflow flow path 204 of the 3-way valve 200 via the fourth tube 340. Here, the reason why a plurality of additional 3-way valves 210 can be provided is because an additional drug container 420 can also be provided together.

[0082] For the injection preparation kit 10 prepared in this manner, a set amount of infusion fluid from the infusion pack 400 connected to the second inflow flow path of the additional three-way valve 210 is introduced into the empty infusion pack 402, and then the outflow flow path of the infusion pack 400 is closed and the outflow flow path 206 of the three-way valve 200 to the drug container 410 is opened, so that a set amount of the medicinal fluid in the drug container 410 is introduced into the empty infusion pack 402 to complete the injection.

[0083] After the preparation of the injection using the cylinder pump 500 is completed, the finishing steps shown in Fig. 12 and Fig. 13 can be performed. Fig. 12 shows the finishing step, in which the drug container 410 and the fourth tube 340 are removed from the cylinder cartridge 100, and the second inlet flow path 204 of the three-way valve 200 connected to the fourth tube 340 is closed. Alternatively, in the finishing step shown in Fig. 13, the drug container 410, the fourth tube 340, and the second tube 320 are removed from the cylinder cartridge 100, and the third tube 330 can be connected to the inlet pipe 150.

[0084] The ends of various tubes must be sterilized and sealed to prevent contamination until the infusion pack 400 is used by a patient. Therefore, the infusion pack 400 prepared in a sterile environment continues to maintain a closed system state centered on the cylinder cartridge 100 through the finishing step, eliminating the problem of contamination and infection. Just before injecting the completed infusion pack 400 into a patient, the cylinder cartridge 100 is attached to the cylinder pump 500, the tube connected to the outlet tube 152 is connected to the patient's catheter, and the prescribed dosage is input into the control unit of the cylinder pump 500, and the cylinder pump 500 is driven to start injection.

[0085] Meanwhile, Fig. 14 shows a modified embodiment of the injection preparation kit 10 according to the present invention. This embodiment assumes that drugs such as anticancer drugs are provided in the form of powder. Powdered drugs cannot be injected intravenously unless they are dissolved and diluted with infusion fluid, and the dilution ratio of the powdered drug is also written on the prescription. Even in such a case, the present invention can mix only the correct amount of diluent using a cylinder pump 500, and an injection preparation kit 10 for this purpose is shown in Fig. 14.

[0086] Since the cylinder pump 500 is intended for liquids (medicinal fluids) and cannot inhale or expel powdered medicines, the injection preparation kit 10 applicable to powdered medicines has a powdered medicine container 430 attached to a first tube 310 connected to the outlet tube 152 of the cylinder cartridge 100, and a diluent pack 404 connected to a second tube 320 connected to the inlet tube 150 of the cylinder cartridge 100. Such an injection preparation kit 10 for powdered medicines drives the cylinder pump 500 to suck in a set amount of diluent from the diluent pack 404 and introduce it into the powdered medicine container 430. The powdered medicine container 430 containing the diluent can be used after being properly shaken to dissolve the diluent sufficiently.

[0087] Here, the diluent pack 404 is used to mean a container containing a diluent, and it goes without saying that the infusion fluid in the infusion pack 400 can be used, but it should be noted that a different term is used because the diluent can be different depending on the properties of the powdered medicine.

[0088] It should also be noted that the dissolved powdered medicine can be handled in the same manner as the normal liquid medicine described above, and therefore the powdered medicine container 430 after the dissolution process can be applied in the same manner as the medicine container 410 or additional medicine container 420 described in Figures 7 to 13, and can be mixed with the infusion pack 400 or empty infusion pack 402 to prepare an injection.

[0089] The above description is merely illustrative of the technical concept of the present invention, and various modifications and variations are possible within the scope of the essential characteristics of the present invention, if one has ordinary knowledge in the technical field to which the present invention pertains. Therefore, the embodiments disclosed in the present invention are for illustrative purposes only and do not limit the technical concept of the present invention, and the scope of the technical concept of the present invention is not limited by these embodiments. [Explanation of symbols]

[0090] 10 Injection preparation kit 100 Cylinder Cartridge 110 Upper case 112 Drive shaft insertion hole 114 Upper Rotating Body 116 First drive shaft fastening hole 118 Upper fastening member 120 Lower housing 122 Lower Rotating Body 124 Second drive shaft fastening hole 126 Lower fastening member 130 Cylinder space 140 First Piston 142 Second Piston 150 Inflow pipe 152 Outflow pipe 200 3-way valve 202 First inlet passage 204 Second inlet channel 206 Outlet Channel 210 Additional 3-way valve 300 Drug container adapter 310 First Tube 320 Second Tube 330 Third Tube 340 4th Tube 400 infusion packs 402 Empty infusion pack 404 Dilution Solution Pack 410 Drug containers 420 Additional Drug Containers 430 Powder medicine container 500 Cylinder Pump 510 Cover 512 Cartridge mounting groove 520 Cylinder drive unit 522 Drive shaft 530 First Drive Unit 532 First drive motor 534 First Warm 536 First Worm Gear 538 First Drive Shaft 540 Second Drive 542 Second Drive Motor 544 Second Warm 546 Second Worm Gear 548 Second Drive Shaft 1000 Injection Dispensing System

Claims

1. A cylinder cartridge for introducing and discharging an external fluid through a change in cylinder volume caused by the relative fixing and rotating of a pair of pistons provided inside, the cylinder cartridge comprising an upper rotor and a lower rotor that are rotatable relative to each other, an annular cylinder space is formed between the upper rotor and the lower rotor, a first piston of the pair of pistons is coupled to the upper rotor and can rotate along the cylinder space, and a second piston is coupled to the lower rotor and can rotate along the cylinder space; a first tube connected to an outlet pipe of the cylinder cartridge; a three-way valve for selectively connecting one of the two inlet flow paths to the outlet flow path; a second tube in which an outlet flow passage of the three-way valve is connected to an inlet pipe of the cylinder cartridge; a third tube connected to the first inlet flow path of the three-way valve; a fourth tube connected to the second inlet flow path of the three-way valve; Including, An infusion pack is connected to the first tube and the third tube, An injection preparation kit, wherein a drug container is connected to the fourth tube.

2. 2. The injection drug preparation kit according to claim 1, wherein the fourth tube and the drug container are connected by an adapter with an air inlet function.

3. A cylinder cartridge which allows external fluid to flow in and out through changes in cylinder volume caused by the action of fixing and rotating a pair of pistons provided inside relatively, said cylinder cartridge comprising upper and lower rotating bodies which are freely rotatable relative to one another, with an annular cylinder space being formed between the upper and lower rotating bodies, a first piston of said pair of pistons being connected to the upper rotating body and capable of rotating along said cylinder space, and a second piston being connected to the lower rotating body and capable of rotating along said cylinder space; a first tube connected to an outlet pipe of the cylinder cartridge; a three-way valve for selectively connecting one of the two inlet flow paths to the outlet flow path; a second tube in which an outlet flow passage of the three-way valve is connected to an inlet pipe of the cylinder cartridge; a third tube connected to the first inlet flow path of the three-way valve; a fourth tube connected to the second inlet flow path of the three-way valve; Including, further comprising at least one additional three-way valve; The injection preparation kit according to claim 1, wherein a first inlet flow passage and an outlet flow passage of the additional three-way valve are connected to any one of the second to fourth tubes.

4. The injection preparation kit according to claim 3, wherein an additional drug container is connected to a second inlet flow path of the additional three-way valve.

5. The injection preparation kit according to claim 3, characterized in that an infusion pack is connected to the second inlet flow path of the additional three-way valve, empty infusion packs are connected to the first tube and the third tube, and a drug container is connected to the fourth tube.

6. The injection preparation kit according to claim 1 , a cylinder pump to which the cylinder cartridge of the injection preparation kit is attached and which independently drives a pair of pistons provided inside the cylinder cartridge; 16. An injectable dispensing system comprising:

7. The cylinder pump includes a cylinder driving unit that independently drives a pair of pistons provided in the cylinder cartridge, and a control unit that controls the cylinder driving unit, The injection drug dispensing system according to claim 6 , wherein the control unit controls the amount and speed of the liquid flowing in and out of the cylinder cartridge to preset values.

8. The injection drug dispensing system according to claim 7, wherein the control unit controls the cylinder driving unit so that a preset amount of drug solution in the drug container connected to the fourth tube flows in and flows out into the infusion pack connected to the first tube.

9. The injection drug dispensing system according to claim 8, wherein the three-way valve has a second inlet flow path connected to the fourth tube and an outlet flow path connected to the second tube in an open state.

10. the cylinder driving unit includes a first driving unit that drives an upper rotating body of the cylinder cartridge and a second driving unit that drives a lower rotating body of the cylinder cartridge; The injection drug dispensing system according to claim 7, characterized in that the injection drug dispensing system has a double-shaft structure in which the second drive shaft of the second drive unit is inserted within the first drive shaft of the first drive unit.

11. The injection drug dispensing system according to claim 10, wherein the first driving unit and the second driving unit each have a worm gear structure.

12. A first step of preparing the injection preparation kit according to claim 1, connecting an infusion pack to the first tube and the third tube, and connecting a drug container to the fourth tube; a second step of mounting the cylinder cartridge of the injection preparation kit on a cylinder pump that independently drives a pair of pistons provided inside the cylinder cartridge; a third step of inputting an amount of the medicinal liquid in the medicine container to be introduced into the infusion pack to the cylinder pump; a fourth step of opening a second inlet passage connected to the fourth tube and an outlet passage connected to the second tube for the three-way valve; A fifth step of driving the cylinder pump to introduce a set amount of the medicinal liquid from the medicinal container into the infusion pack; A method for preparing an injection comprising the steps of:

13. After the fifth step, The method for preparing injections according to claim 12, characterized in that the three-way valve is operated to form a circulation flow path for the infusion by opening the first inflow flow path connected to the third tube and the outflow flow path connected to the second tube, and the cylinder pump is operated to circulate the infusion in the infusion pack through the cylinder cartridge, thereby taking in any medicinal liquid remaining in the tube into the infusion pack.

14. The injection preparation method according to claim 12, further comprising a priming step between the third step and the fourth step for removing air from the first to third tubes.

15. The priming step comprises: opening a first inlet flow passage connected to the third tube and an outlet flow passage connected to the second tube for the three-way valve; The method for preparing an injection according to claim 14, characterized in that the infusion in the infusion pack is circulated through the cylinder cartridge to remove air from the first to third tubes.

16. replacing said drug container with another additional drug container; The injection preparation method according to claim 12, further comprising the step of driving the cylinder pump to introduce a set amount of the medicinal liquid from the additional medicinal container into the infusion pack.

17. The first step includes: A first inflow flow path and an outflow flow path of at least one or more additional three-way valves are connected to any one of the second to fourth tubes, and an additional drug container is connected to a second inflow flow path of the additional three-way valve; After the fifth step, a further mixing step of closing the outflow passage to the drug container and opening the outflow passage to the additional drug container, and driving the cylinder pump to introduce a set amount of the drug solution from the additional drug container into the infusion pack; The method for preparing an injection according to claim 12, further comprising the steps of:

18. The first step includes: The method includes a step 1-1 of connecting an empty infusion pack to the first tube and the third tube, connecting a first inflow flow path and an outflow flow path of at least one additional three-way valve to any one of the second to fourth tubes, and connecting an infusion pack to a second inflow flow path of any one of the additional three-way valves; The third to fifth steps are: The injection preparation method according to claim 12, characterized in that a set amount of infusion liquid from an infusion pack connected to the second inflow flow path of the additional three-way valve is introduced into the empty infusion pack, and then the outflow flow path of the infusion pack is closed and the outflow flow path to the drug container is opened to introduce a set amount of the medicinal liquid in the drug container into the empty infusion pack.

19. After the fifth step, For the cylinder cartridge, removing the drug container and the fourth tube and closing the second inlet flow path of the three-way valve; Alternatively, the method for preparing an injection according to claim 12 further comprises a finishing step of removing the drug container, the fourth tube and the second tube, and connecting the third tube to an inlet pipe.

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