Implants, biomonitoring systems and biocontrol systems

Abstract

Provided is a biomonitoring system (20) that has an analyzer (30) and an implant (50) embedded under the skin of an organism (1) wherein the implant is connected to a blood vessel (7) under the skin and forms a blood flow to an inspection port (51) that is disposed above the epidermis, within the epidermis, or directly under the epidermis.The analyzer has an irradiation device (31) that irradiates a laser (71) onto the inspection port of the implant embedded under the skin of the organism, and has a detector (32) that detects scattered light (75) from the inspection port.

Description

[Technical field]

[0001] The present invention relates to an implant that is embedded in a living body such as a human being, and a system that uses the implant to monitor and manage the living body. [Background technology]

[0002] International Publication WO2014 / 178199 discloses a monitor for monitoring the state inside a living body from the surface of the living body. The monitor includes a probe including an observation window attached to the surface of the living body, a unit for irradiating a laser onto at least a part of an observation area on the surface of the living body accessed through the observation window, a unit for detecting scattered light 28 caused by the laser irradiation from each of a plurality of observation spots distributed two-dimensionally in the observation area, a Doppler analysis unit and a SORS analysis unit for limiting a first observation spot from which it is determined that scattered light containing information on a target part inside the living body is obtained based on the scattered light obtained from the plurality of observation spots, and a CARS analysis unit for acquiring a spectroscopic spectrum of at least one component from the first observation spot or an observation spot around it, and outputting first information indicating the state inside the living body based on its intensity. DISCLOSURE OF THEINVENTION

[0003] When attempting to non-invasively obtain information about the inside of a living body, particularly various types of information contained in blood flowing through blood vessels, using light, such as laser light, with high accuracy, the effects of absorption and / or scattering by the skin and tissues below the skin become a problem. Therefore, it is desirable to be able to eliminate these effects.

[0004] One aspect of the present invention is an implant that is embedded under the skin of a living body, the implant having a connection end connected to a blood vessel under the skin, and an examination port that is provided on, in, or just under the epidermis, and through which blood flow is formed. Instead of removing information about the skin and tissue under the skin that is included when acquiring scattered light from blood vessels under the skin, the implant forms a blood flow above, in, or just under the epidermis, thereby eliminating or minimizing the effects of absorption and / or scattering by the skin. Therefore, various information contained in the blood flowing through the blood vessels can be acquired with high accuracy by a non-invasive analysis device using a laser.

[0005] Various methods, such as infrared absorption, can be used to detect components in blood non-invasively, but Raman spectroscopy is one of the best methods. The test port may be made of a material with high transmittance of light in the red to near-infrared wavelength range to obtain Raman scattered light. The implant may be made of a transparent material such as glass, or may be made of a flexible resin material, such as a silicone resin or a biomaterial.

[0006] Another aspect of the present invention is an analysis device to be attached to the skin of a living body, the analysis device having an irradiation device (irradiation unit) that irradiates a laser to the inspection port of the above-mentioned implant buried under the skin of the living body, and a detector (detection unit) that detects scattered light from the inspection port. The analysis device may further have a search device that searches for an inspection port provided on, in, or just under the epidermis, and controls the irradiation destination of the laser. The implant is buried in the skin so that the inspection port where blood flow is formed is located near the epidermis. Therefore, the inspection port is highly likely to be observable from the skin surface, and the search device may have a function of recognizing the inspection port by an image. In addition, since the inspection port is located near the epidermis, the scattered light containing a component corresponding to the blood flow can be clearly distinguished from the scattered light not containing a component corresponding to the blood flow by scanning the vicinity of the inspection port with a laser to obtain scattered light. Therefore, the search device may have a function of performing pre-processing to obtain scattered light by scanning the vicinity of the position where the inspection port is expected to be located with a laser, and to determine the position of the inspection port from the information.

[0007] The irradiation device may include a focusing device (light focusing unit) that focuses at least two laser beams, for example, a Stokes beam for generating Raman scattered light and a pump beam, to form a common spot at the inspection port. The analysis device may further include an optical tweezers device that forms an optical trap in the inspection port. The analysis device may further include an electromagnetic field generating device that performs microfluidic control of the fluid in the inspection port.

[0008] Another aspect of the present invention is a biological monitoring system (biological monitoring device) or a biological monitoring device kit (device set, assembly kit) having the above-described implant and an analytical device. By embedding the implant in a living body and attaching the analytical device to the surface (skin) of the living body so that a laser is irradiated to the inspection port, various components in the blood can be detected non-invasively and with high accuracy. Therefore, a biological monitoring system can be provided that can accurately and continuously monitor information about the living body without imposing a burden on the living body.

[0009] Another aspect of the present invention is a biological management system (biological management device) or biological management device kit having the above-mentioned biological monitoring system (biological monitoring device kit) and a drug administration device (injection device) that injects a drug into a living body through the skin based on the state of the living body obtained by an analysis device. By embedding an implant in a living body, attaching an analysis device to the surface (skin surface) of the living body so that a laser is irradiated to the inspection port, and further attaching an injection device to the skin, it is possible to provide a biological management system that can accurately and continuously monitor information about the living body through various components in the blood non-invasively and without placing a burden on the living body, and based on that, can inject a desired drug into the living body at the required time and in the required amount.

[0010] Another aspect of the present invention is a method for monitoring the condition of a living organism. The method includes embedding an implant under the skin of a living organism and connecting it to a blood vessel under the skin, forming a blood flow in an examination port provided on, in, or just under the epidermis, and irradiating a laser onto the examination port with an analysis device attached to the surface of the living organism (on the skin of the living organism) and detecting scattered light obtained from the examination port. The method may include forming an optical trap in the examination port with an optical tweezers device. Furthermore, the method may include performing microfluidic control of a fluid in the examination port with an electromagnetic field generating device. The method may also include injecting a drug into the living organism through the skin with a drug administration device based on the state of the living organism obtained by the analysis device. [Brief description of the drawings]

[0011] [Figure 1] FIG. 1 shows an example of a biometric management system worn on the skin. [Diagram 2] FIG. 13 shows another example of a biometric management system attached to the skin. [Diagram 3] 4 is a flowchart showing an outline of the operation of the biometric management system. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0012] FIG. 1 shows an example of a biological management system (health management system) 10 that manages the health condition of a living organism, for example, a human body 1. The biological management system 10 includes a biological monitoring system 20 that monitors the state of the living organism 1, and a drug administration system (medication device) 60 that injects a drug to maintain the health of the living organism 1. The biological monitoring system 20 is provided by a biological monitoring kit 25 that includes an implant 50 embedded in the living organism 1 and an analysis device 30 that monitors the state of the living organism 1 through the implant 50. An example of the analysis device 30 is a wearable mobile terminal 40 with a built-in communication function and user interface, such as a smart watch. The drug administration system 60 is provided by an injection kit 65 that includes an injector 61 that injects a drug through the skin 5 of the living organism 1, and a supply device (supply unit) 63 that supplies a predetermined drug to the injector 61. The biological management system 10 is provided by a biological management kit 15 that includes the biological monitoring kit 25 and the drug administration kit (injection kit) 65.

[0013] An example of the implant 50 is a flexible or predetermined shaped implant (bioport, embedded body, implant body, implant flow channel, implant port) embedded in the skin 5 (under the skin) of the living body 1. The implant 50 has a connection end 53 connected to a blood vessel 7 under the skin, and an inspection port (inspection window, access part for inspection) 51 provided or appearing (located) on the epidermis 3, in the epidermis 3 or just under the epidermis 3, and blood flow is formed in the inspection port 51 through the connection end 53. An example of the implant 50 is an artificial blood vessel that has portions 53 at both ends connected to blood vessels 7 under the skin (for example, veins and arteries in the dermis or subcutaneous tissue) and has the inspection port 51 in the center, and can be molded or deformed into an arch, U-shape, V-shape, or the like. The shape of the inspection port 51 may be cylindrical or flat, and may be any shape or structure that is easily compatible with laser irradiation, and may form an expanded shape or flow channel with respect to the end 53. The implant 50 may be formed from a silicone resin or other resin that is highly transparent to infrared and near infrared radiation, or from a suitable biomaterial, such as a material that dissolves or is absorbed by the body.

[0014] The implant 50 may be embedded in the living body 1 by a simple surgery, or may be inserted from the surface of the living body like a needle or catheter for intravenous drip. By forming a blood flow close to the outside world, such as above or below the epidermis 3, using the implant 50, it is possible to eliminate or minimize the influence of absorption and / or scattering of light for spectroscopic analysis or absorption analysis by the skin (dermis, subcutaneous tissue) or the like. The implant 50 may be embedded in any place in the living body 1 as long as it can be connected to a subcutaneous blood vessel 7. When the analysis device 30 is mounted on a mobile terminal 40 such as a smart watch, the implant 50 may be embedded in a place where the mobile terminal 40 is worn, for example, in the skin on the wrist where the smart watch is worn.

[0015] The analysis device 30 is a non-invasive analysis device using a laser, and by irradiating the test port 51 of the implant 50 with a laser, it accurately obtains various information contained in the blood artificially formed in the epidermis 3. The analysis device 30 may employ various analysis methods such as infrared absorption. The analysis device 30 of this example has an irradiation device (irradiation unit) 31 that irradiates the test port 51 of the implant 50 with a laser 71, and a detector (detection unit) 32 that detects scattered light 75 from the test port 51. The irradiation device 31 includes at least two laser lights 71, in this example, a focusing device (light focusing unit) 33 that focuses Stokes light and pump light for generating Raman scattered light (CARS light) on a common spot on the test port 51, for example an objective lens. The irradiation device 31 may be a device that irradiates probe light in addition to Stokes light and pump light as the laser light 71.

[0016] The light collecting device 33 may include a device (irradiation position control device, irradiation position control optical system) 34 that controls the laser light 71 to be directed to the position of the implant 50 in order to detect (measure) the blood composition. The irradiation position control device 34 may further include a function of scanning the inspection port 51 of the implant 50 or of collecting light at multiple points to select an optimal spot so that the optimal location of the implant 50 can be selected and irradiated with the laser light 71. The irradiation position control device 34 may be a device that controls the position and orientation of the objective lens 33, or may be a device that controls the irradiation direction and angle of the laser using a reflecting device such as a digital mirror device.

[0017] The implant 50 is embedded in the skin 5 so that the test port 51 where blood flow is formed is located near the epidermis. Therefore, the test port 51 is highly likely to be visible from the skin surface, and the analysis device 30 can be attached on the skin in accordance with the position of the test port 51. The analysis device 30 may further include a search device (search function) 35a that searches for a specific (detailed) position of the test port 51 provided on, within, or just below the epidermis, and controls the irradiation destination of the laser light 71. An example of the search device 35a may be a device (function) that acquires an image of the skin surface to recognize the position of the test port, a device that measures blood flow using the Doppler effect, or an image processing function such as OCT, or a device that scans the periphery of the test port 51 with the laser light 71 and determines the position of the test port 51 based on whether or not the scattered light 75 contains a blood component, for example, glucose.

[0018] This analysis device 30 includes a searching device 35a that detects the position of the inspection port 51 with high accuracy by using a laser light 71. The inspection port 51 is located near the epidermis. Therefore, the searching device (function) 35a scans the vicinity of the position where the inspection port 51 is expected to appear with the laser light 71 to obtain scattered light 75, thereby making it possible to clearly distinguish between scattered light that contains a component corresponding to blood flow and scattered light that does not contain a component corresponding to blood flow. The searching device 35a may perform a process (pre-processing) of determining the position of the inspection port 51 and determining the irradiation position of the laser light 71 before the start of measurement, intermittently during measurement, or in parallel with the measurement.

[0019] An example of a spectroscopic analysis type analysis module (analytical device) 30 is a Raman analytical device, and in particular, a CARS (Coherent Anti-Stokes Raman Scattering) analytical device, an SRS (Stimulated Raman Scattering) analytical device, a time-resolved CARS analytical device, etc., which are suitable for trace analysis, may be adopted.

[0020] The analysis device 30 includes a controller (control device, control unit) 35 equipped with a function 35b for controlling the irradiation device 31 and analyzing the measurement results by the scattered light 75 obtained by the detector 32, and a function 35a for controlling the irradiation device 31 and the detector 32 as a searching device. The controller 35 may further include a function (communication function) for providing the measurement results to an external system, for example, an external system such as a health management server on the cloud, a function for coordinating with the medication system 60, and the like.

[0021] The analysis device 30 may further include an optical tweezers device 37 that outputs laser light 77 that forms an optical trap within the inspection port 51. When laser light is focused to the maximum extent using an objective lens with a high numerical aperture, optical tweezers generate a force that traps particles of about micrometer size due to the transfer of momentum caused by scattering of photons. Therefore, the optical tweezers device 37 can trap particles or molecules of a predetermined size from the blood flowing through the inspection port 51 and make them the subject of Raman spectroscopic analysis.

[0022] The analysis device 30 may further include an electromagnetic field generating device 38 for performing microfluidic control of the fluid in the test port 51. The electromagnetic field generating device 38 may include a function for controlling the flow rate of blood flowing through the implant 50, and may have a function for ensuring blood flow in the implant 50 within a range that does not inhibit the function of the blood vessel 7 to which the implant 50 is connected, and for changing the blood flow rate between when measurement is performed and when not measurement is performed. In addition, by using the microfluidic control and / or optical tweezers (optical trap) of the electromagnetic field generating device 38, or by controlling and cooperating these with the control device 35, a structure for capturing and / or filtering molecules or particles in the blood, such as a nano-sized molecular sieve or nanopen chamber, can be dynamically formed in the test port 51. Therefore, components in the blood can be detected steadily, continuously, accurately, and non-invasively without inhibiting the flow of blood in the blood vessel 7 of the living body 1 or without generating a state harmful to the living body 1, such as a blood clot, in the implant.

[0023] Examples of molecules that can be captured by the analytical device 30 via the implant 50 include not only blood cells such as red blood cells, white blood cells, lymphocytes, and platelets, but also all molecules that may be present in blood, such as antibodies, antibody fragments, genetically modified antibodies, single-chain antibodies, receptor proteins, binding proteins, enzymes, inhibitor proteins, lectins, cell adhesion proteins, oligonucleotides, polynucleotides, nucleic acids, and aptamers. The monitoring system 20 with the implant 50 and the analyzer 30 may detect and / or identify any atom, chemical, molecule, compound, composition, microorganism or aggregate, including, but not limited to, blood cells, amino acids, peptides, polypeptides, proteins, glycoproteins, lipoproteins, nucleosides, nucleotides, oligonucleotides, nucleic acids, sugars, carbohydrates, oligosaccharides, polysaccharides, fatty acids, lipids, hormones, metabolites, cytokines, chemokines, receptors, neurotransmitters, antigens, allergens, antibodies, substrates, metabolites, cofactors, inhibitors, drugs, pharmaceuticals, nutrients, prions, toxins, poisons, explosives, pesticides, chemical warfare agents, biological hazards, radioisotopes, vitamins, heterocyclic aromatic compounds, carcinogens, mutagens, narcotics, amphetamines, barbiturates, hallucinogens, waste products, and / or pollutants. Microorganisms include, but are not limited to, viruses, bacteria, cells, and the like.

[0024] Therefore, by using a biological monitoring device kit (assembly set) 25 having this implant 50 and the analyzer 30, it is possible to provide a biological monitoring system 20 that detects various components in blood non-invasively and with high accuracy by embedding the implant 50 in the living body 1 and attaching the analyzer 30 to the surface of the living body 1 so that a laser is irradiated to the inspection port 51. Furthermore, by using the biological monitoring device kit 25, it is possible to provide a biological monitoring system 20 that can accurately and continuously monitor information about the living body 1 without placing a burden on the living body 1.

[0025] The medication system 60 includes a drug injection device (supply device) 63 that supplies (injects) a required amount of drug at a required timing based on the measurement results of the analysis device 30 to maintain the health of the living body 1 in a specified state, and an injector 61 for drug injection attached to the skin 5. The injector 61 may be one that uses a microneedle, or may be a needleless type that injects a drug solution through the skin by spraying it without using a needle.

[0026] It is possible to provide a biological management device kit (a biological management device assembly set) 15 having a biological monitoring kit 25 and a medication kit 65 for injecting a drug into the biological body 1 through the skin 5 based on the state of the biological body 1 obtained by the analysis device 30. With this biological management device kit 15, the implant 50 is embedded in the biological body 1, the analysis device 30 is attached to the surface (skin surface, on the skin) of the biological body 1 so that a laser is irradiated to the inspection port 51, and further, the injector 61 of the injection device 60 is attached to the skin 5, particularly the epidermis 3, so that the biological management system 10 can be attached to the biological body 1. The biological management system 10 can accurately and continuously monitor information about the biological body 1 through various components in the blood non-invasively and without placing a burden on the biological body 1, and based on the information, a desired drug can be injected into the biological body at the required time and in the required amount.

[0027] In the biomedical management system (health management system) 10, the analysis system (monitor) 20 can continuously and accurately measure blood glucose in real time. Therefore, the dosage of insulin can be precisely controlled based on the glucose concentration continuously measured by the medication system 60. Furthermore, the biomedical management system 10 may have a function such as an event recognition module that can predict or understand the behavior or lifestyle of a living body (human body). The biomedical management system 10 may detect various behaviors including the occurrence of events (patient activities) such as exercise and meals, and further predict the patient's activities using a daily schedule and the output of various sensors, and may determine the type and amount of medication to be administered, for example, the type and amount of insulin, so as to correspond to the predicted state. For this reason, for example, the glucose concentration in blood can be controlled to a narrow range that has little effect on health. Therefore, by wearing the biomedical management system 10, even a diabetic patient can play sports and eat meals in the same way as a healthy person.

[0028] The physiologically active substance injected from the injection system (medication system, drug delivery system) 60 is not limited to insulin, but may be other hormones, prescription drugs, minerals, nutrients, etc. The biomedical management system 10 may include a function for determining and controlling the type and amount of medicine (dosage estimation function). The biomedical management system 10 may also include a system for occasionally or continuously sharing real-time information of the living body and information on medication obtained by the system 10 with an external monitoring system, for example, a medical or insurance system.

[0029] 2 shows systems 10 and 20 using implants 50 of different shapes. The shape of the implant 50 is not specified, and by embedding the implant 50 in the skin 5, it is connected to blood vessels 7 in the skin (under the skin) or in the subcutaneous tissue, and a blood flow that reflects information on the living body 1 in real time is obtained in or near (above and below) the epidermis 3 via the inspection port 51. Therefore, by using the analysis device 30 to analyze the components of the blood flow in the inspection port 51 using a non-invasive measurement method (detection method) such as Raman spectroscopy, the state of the living body 1 can be accurately measured in real time.

[0030] 2 is a dedicated terminal 45 for providing the biological management system 10. The dedicated terminal 45 may incorporate a function as the medication system 60 in addition to the function as the analysis device 30, and may be attached to the skin 5 using a close-fitting pad 49 or the like. The method of attaching the terminal 45 is not limited as long as it is a method that can fix the terminal 45 to a predetermined position on the skin 5.

[0031] The analysis device 30 includes an imaging element, such as a CCD 39, for capturing an image of the state of the epidermis 3. The search device 35a may analyze the obtained image, determine the detailed position of the inspection port 51, and control the irradiation position of the laser light 71.

[0032] FIG. 3 shows an outline of a process (method) for monitoring the state of the living body 1 by the above-mentioned system 10 or 20. First, in step 81, an implant 50 is embedded under the skin (in the skin) 5 of the living body 1, and both ends 53 of the implant 50 are connected to blood vessels 7 under the skin (in the skin), thereby forming a blood flow in an inspection port 51 provided on the epidermis 3, in the epidermis 3, or just under the epidermis 3. The implant 50 may connect arteries of the blood vessels 7, connect veins, or connect an artery and a vein, depending on the state of the patient and the symptoms or conditions of the monitored subject. The implant 50 may be embedded in advance by a simple surgery, or may be installed by the patient using a jig for embedding the implant 50. The implant 50 may be made of a material that dissolves or is absorbed by the living body 1, and a process of embedding the implant 50 may be performed periodically.

[0033] In step 84, the analyzer 30 attached to the surface of the living body, for example, the skin 5, irradiates the inspection port 51 with a laser 71, and detects the scattered light 75 obtained from the inspection port 51, which is CARS light in this example. Prior to this process, in step 82, the position of the inspection port 51 may be searched for and it may be determined whether or not the irradiation position needs to be adjusted, for example, by pre-analyzing the scattered light 75. If the irradiation position needs to be adjusted, in step 83, the search device 35a is used to search for the detailed position of the inspection port 51.

[0034] In step 84, CARS light 75 is detected, and in step 85, if it is requested to form an optical trap in inspection port 51, an optical trap is formed by optical tweezers device 37 in step 86. Also, in step 87, if it is necessary to control the flow rate in inspection port 51, an electromagnetic field is formed in inspection port 51 by electromagnetic field generating device 38 in step 88, and microfluidic control of the fluid is performed.

[0035] In step 89, the CARS light 75 obtained while performing these controls on the blood flow formed in the inspection port 51 is analyzed to obtain information on the target component in the blood. Furthermore, in step 90, the biomedical management system 10 may monitor or observe the behavior of the living body (user) 1 based on information obtained from other functions of the mounted wearable device, such as an accelerometer, information from other wearable devices, and even information obtained from an internet (cloud) server.

[0036] In step 91, the necessity of medication is determined based on the information obtained by the analysis device 30 and further based on the information obtained by behavioral observation, and the medication can be injected by the medication system 60 in step 92. The medication system 60 may inject a medication into the living body 1 through the skin by the injection device (injector) 61 based on the condition of the living body 1 obtained by the analysis device 30.

[0037] The method for monitoring the condition of a living body, including the above-mentioned process, may be provided as a program (program product) stored in a computer-readable recording medium for controlling the monitoring system 20 including the analysis device 30 and the management system 10. In addition, the method for monitoring the condition of a living body may be provided as a program that can be downloaded via the Internet or the like, or may be provided as a service via the Internet.

[0038] It should be noted that, although particular embodiments of the present invention have been described above, various other embodiments and modifications may be conceived by those skilled in the art without departing from the scope and spirit of the present invention, and such other embodiments and modifications are within the scope of the following claims, which define the present invention.

Claims

1. An analytical device to be attached to the skin of a living body, comprising: an irradiation device for irradiating a laser onto the implant buried under the skin of the living body; a detector for detecting scattered light from the implant; The implant comprises: an artificial blood vessel that can be molded or deformed into an arch, U-shape, or V-shape; The artificial blood vessel has a connection end to be connected to a blood vessel under the skin; an inspection port provided on, within, or just below the epidermis, close to the outside world relative to the blood vessels under the skin, and through which a blood flow is formed via the connection end; The analysis device further includes a search device that searches for the inspection port provided on, within, or just below the epidermis and controls the irradiation destination of the laser, An analysis device, wherein the illumination device illuminates the inspection port of the implant with a laser, and the detector detects scattered light from the inspection port.

2. In claim 1, An analytical device, wherein the inspection port is formed from a material having high transmittance for light of wavelengths from red to near infrared.

3. An analytical device to be attached to the skin of a living body, comprising: an irradiation device for irradiating a laser onto the implant buried under the skin of the living body; a detector for detecting scattered light from the implant; The implant comprises: an artificial blood vessel that can be molded or deformed into an arch, U-shape, or V-shape; The artificial blood vessel has a connection end to be connected to a blood vessel under the skin; an inspection port provided on, within, or just below the epidermis, close to the outside world relative to the blood vessels under the skin, and through which a blood flow is formed via the connection end; An analysis apparatus, wherein the illumination device includes a focusing device that focuses at least two laser beams to form a common spot at the inspection port, and the detector detects scattered light from the inspection port.

4. An analytical device to be attached to the skin of a living body, comprising: an irradiation device for irradiating a laser onto the implant buried under the skin of the living body; a detector for detecting scattered light from the implant; The implant comprises: an artificial blood vessel that can be molded or deformed into an arch, U-shape, or V-shape; The artificial blood vessel has a connection end to be connected to a blood vessel under the skin; an inspection port provided on, within, or just below the epidermis, close to the outside world relative to the blood vessels under the skin, and through which a blood flow is formed via the connection end; The analytical apparatus further comprises an optical tweezers device forming an optical trap within the inspection port; An analysis device, wherein the illumination device illuminates the inspection port of the implant with a laser, and the detector detects scattered light from the inspection port.

5. An analytical device to be attached to the skin of a living body, comprising: an irradiation device for irradiating a laser onto the implant buried under the skin of the living body; a detector for detecting scattered light from the implant; The implant comprises: an artificial blood vessel that can be molded or deformed into an arch, U-shape, or V-shape; The artificial blood vessel has a connection end to be connected to a blood vessel under the skin; an inspection port provided on, within, or just below the epidermis, close to the outside world relative to the blood vessels under the skin, and through which a blood flow is formed via the connection end; The analytical device further comprises an electromagnetic field generating device for performing microfluidic control of the fluid in the test port; An analysis device, wherein the illumination device illuminates the inspection port of the implant with a laser, and the detector detects scattered light from the inspection port.

6. A biological monitoring system comprising the analyzer according to any one of claims 1 to 5 and the implant.

7. The biological monitoring system according to claim 6 ; and a medication device that injects a drug into the living body through the skin based on the condition of the living body obtained by the analysis device.

8. An implant to be embedded under the skin of a living body, comprising: The artificial blood vessel can be molded or deformed into an arch, U-shape, or V-shape; The artificial blood vessel has a connection end to be connected to a blood vessel under the skin; an implant having an examination port provided on, within, or just below the epidermis, close to the outside world relative to the blood vessels under the skin, and through which a blood flow is formed via the connection end; An analytical device that is attached to the skin of a living body, an irradiation device that irradiates a laser onto the inspection port of the implant embedded under the skin of the living body; an analyzer having a detector for detecting scattered light from the test port; and a medication device that injects a drug into the living body through the skin based on the condition of the living body obtained by the analysis device.

9. A method for controlling a system for monitoring a condition of a living body, comprising: The system includes an analysis device that is attached to the skin of the living body, the analysis device including a device that emits a laser, a detector that detects scattered light, and a search device that controls a destination of the laser, and the control method includes: an analysis device attached to the skin of the living body emits the laser to the inspection port of an artificial blood vessel including an inspection port, the artificial blood vessel being embedded under the skin of the living body and connected to a blood vessel under the skin, and capable of being molded or deformed into an arch, U-shape or V-shape, and forming a blood flow in the inspection port provided on, within or just under the epidermis close to the outside world relative to the blood vessel under the skin; and detects scattered light obtained from the inspection port; The control method includes the step of: causing the searching device of the analysis device to search for the inspection port provided on, within, or just below the epidermis, and controlling a destination of the laser.

10. A method for controlling a system for monitoring a condition of a living body, comprising: The system includes an analysis device that is attached to the skin of the living body, the analysis device including a device that emits a laser, a detector that detects scattered light, and an optical tweezers device that forms an optical trap, and the control method includes: an analysis device attached to the skin of the living body emits the laser to the inspection port of an artificial blood vessel including an inspection port, the artificial blood vessel being embedded under the skin of the living body and connected to a blood vessel under the skin, and capable of being molded or deformed into an arch, U-shape or V-shape, and forming a blood flow in the inspection port provided on, within or just under the epidermis close to the outside world relative to the blood vessel under the skin; and detects scattered light obtained from the inspection port; and causing the optical tweezers device of the analytical device to form an optical trap within the inspection port.

11. A method for controlling a system for monitoring a condition of a living body, comprising: The system includes an analysis device that is attached to the skin of the living body, the analysis device including a device for emitting a laser, a detector for detecting scattered light, and an electromagnetic field generating device, and the control method includes: an analysis device attached to the skin of the living body emits the laser to the inspection port of an artificial blood vessel including an inspection port, the artificial blood vessel being embedded under the skin of the living body and connected to a blood vessel under the skin, and capable of being molded or deformed into an arch, U-shape or V-shape, and forming a blood flow in the inspection port provided on, within or just under the epidermis close to the outside world relative to the blood vessel under the skin; and detects scattered light obtained from the inspection port; the electromagnetic field generating device of the analytical device performing microfluidic control of fluid in the test port.

12. A method for controlling a system for monitoring a condition of a living body, comprising: The system includes an analysis device that is attached to the skin of the living body, and a drug administration device that injects a drug into the living body through the skin, the analysis device including a device that emits a laser and a detector that detects scattered light, and the control method includes: an analysis device attached to the skin of the living body emits the laser to the inspection port of an artificial blood vessel including an inspection port, the artificial blood vessel being embedded under the skin of the living body and connected to a blood vessel under the skin, and capable of being molded or deformed into an arch, U-shape or V-shape, and forming a blood flow in the inspection port provided on, within or just under the epidermis close to the outside world relative to the blood vessel under the skin; and detects scattered light obtained from the inspection port; The control method includes the analysis device controlling the medication device based on the state of the living body obtained by the analysis device.

13. In any one of claims 9 to 11, The system includes a drug delivery device for injecting a drug into the living body through the skin; The control method further comprises the analysis device controlling the medication device based on the state of the living body obtained by the analysis device.

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