Lipid metabolism promoter

Abstract

To provide a composition superior in enhancing lipid metabolism during physical exercises.SOLUTION: A composition includes as active components two or more kinds of poorly-digestible edible compositions selected from a group consisting of maltitol, galactooligosaccharide, glucomannan, lactose, fructo-oligosaccharide, isomaltooligosaccharide, cellobiose, xylooligosaccharide, xylitol, sorbitol, erythritol, mannitol, pectin, resistant starch, poorly-digestible dextrin, and reduced poorly-digestible dextrin.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for promoting lipid metabolism through exercise. [Background technology]

[0002] Normally, during exercise, glycogen is used first, but then fat begins to be used. The fat stored in adipose tissue is hydrolyzed into fatty acids and glycerol, and the fatty acids are bound to albumin and transported through the blood and passed to the cells of each tissue in the body. The fatty acids taken into the cells are oxidized in the mitochondria to release energy. A combination of dietary restriction therapy and exercise therapy is used to prevent or treat obesity, and preferentially promoting lipid metabolism during exercise is favorable for reducing body fat percentage. Also, for athletes who are subject to weight restrictions, it is preferable to preferentially remove fat rather than muscle during weight adjustment. Furthermore, in athletic competitions that require endurance, if fat-derived energy is used in the early stages of the competition and carbohydrate-derived energy is preserved for the later stages, performance can be expected to improve. On the other hand, it is known that when healthy adults ingest indigestible food ingredients, intestinal bacteria in the large intestine generate hydrogen gas (Patent Document 1, Non-patent literature 1 However, the effect of indigestible food ingredients in efficiently promoting lipid metabolism through exercise is unknown. [Patent Document 1] WO 2017 / 057718 [Non-Patent Document 1] J Functional Foods 35:13-23,2017 Summary of the Invention [Problem to be solved by the invention]

[0003] An object of the present invention is to provide a composition for promoting lipid metabolism during exercise. [Means for solving the problem]

[0004] As a result of intensive research, the inventors have discovered that a composition containing as active ingredients two or more types of resistant food components selected from the group consisting of maltitol, galactooligosaccharides, glucomannan, lactose, fructooligosaccharides, isomaltooligosaccharides, cellobiose, xylooligosaccharides, xylitol, sorbitol, erythritol, mannitol, pectin, resistant starch, resistant dextrin, and reduced resistant dextrin, has the effect of promoting lipid metabolism during exercise, and have completed the present invention. That is, the present invention provides a composition for promoting lipid metabolism during exercise, which comprises the above-mentioned indigestible food component as an active ingredient.

[0005] The aspects of the present invention are as follows. [1] A composition for promoting lipid metabolism during exercise, comprising as active ingredients two or more types of resistant food ingredients selected from the group consisting of maltitol, galactooligosaccharides, glucomannan, lactose, fructooligosaccharides, isomaltooligosaccharides, cellobiose, xylooligosaccharides, xylitol, sorbitol, erythritol, mannitol, pectin, resistant starch, resistant dextrin, and reduced resistant dextrin. [2] The composition described in [1], wherein the indigestible food ingredient comprises maltitol, galactooligosaccharide, and glucomannan. [3] Exercise reduces your maximum oxygen intake (VO 2 [1] or The composition described in [2]. [4] Exercise reduces your maximum oxygen intake (VO 2 Maximum load of 70~80% motion The combination according to [3] Composition. [5] The composition according to any one of [1] to [4], wherein the indigestible food ingredient is contained in an amount of about 0.1% w / w to about 20% w / w of the composition. [6] The composition according to any one of [1] to [5], wherein the composition is a food or drink. [7] The composition described in [6], wherein the food or beverage is a dairy product. [8] The composition described in [7], wherein the dairy product is a milk beverage. [9] Apply approximately 3 to 5 hours before exercise. Either The composition described.

[10] The composition according to any one of [1] to [9], which is used for the prevention or treatment of obesity or metabolic syndrome.

[11] The composition described in any of [1] to [9] is applied to athletes in sports requiring endurance or sports with weight restrictions. Effect of the Invention

[0006] According to the composition of the present invention, a composition and method for promoting lipid metabolism during exercise can be provided. According to the composition of the present invention, lipid metabolism can be preferentially promoted during exercise. Therefore, when the composition of the present invention is combined with short-term exercise, weight loss can be achieved without difficulty, and it can be used for the prevention or treatment of obesity or metabolic syndrome. The composition of the present invention can preferentially remove fat rather than muscle during weight adjustment, even in athletes with weight restrictions. Furthermore, in athletic competitions requiring endurance, the composition of the present invention can be expected to improve performance because it uses fat-derived energy in the early stages of the competition and conserves carbohydrate-derived energy for the latter stages of the competition. [Brief description of the drawings]

[0007] [Figure 1] FIG. 1 shows the change in fat oxidation over time for 60 minutes from the start of exercise when milk containing added non-digestible food ingredients was consumed, compared with when a placebo drink was consumed. [Diagram 2]Figure 2 shows the change over time in the amount of carbohydrate oxidation (C) (amount of oxidation of polysaccharides) over 60 minutes from the start of exercise when milk containing added non-digestible food ingredients was consumed, compared with when a placebo drink was consumed. [Diagram 3] Figure 3 shows the change over time in the amount of carbohydrate oxidation (G) (amount of glucose oxidation) over 60 minutes from the start of exercise when milk containing added non-digestible food ingredients was consumed, compared with when a placebo drink was consumed. [Figure 4] FIG. 4 shows the change over time in respiratory exchange ratio over 60 minutes from the start of exercise when milk containing added non-digestible food ingredients was consumed, in comparison with when a placebo drink was consumed. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] In the present invention, the maximum oxygen intake (VO 2 "Max" refers to the amount of oxygen intake at which oxygen consumption stops changing as the load is gradually increased using a treadmill or bicycle ergometer. In the present invention, "exercise" includes low-intensity exercise to high-intensity exercise, for example, maximum oxygen intake (VO 2 High-intensity exercise is performed at a load of 20-80% of the VO 2 At a load of 65% or more, moderate intensity exercise is called VO 2 Max 45-65% load, low intensity, VO 2 This refers to exercise at a load of 45% or less of the maximum oxygen intake (VO 2 Exercise at a load of 20% of the maximum load is exercise with an intensity of about 90 heart rate, such as walking. The exercise is preferably high-intensity exercise. Preferred high-intensity exercise is exercise that generates a significant amount of active oxygen that exceeds the antioxidant defense function of the body, and is preferably exercise at a load of VO 2 Exercise at a load of 70-80% of max. More preferably, 75% VO 2 When the composition of the present invention was used, as demonstrated in the examples below, lipid metabolism was enhanced during exercise lasting from about 3 minutes to about 1 hour. VO 2Examples of exercise that is 70-80% of your max include endurance sports, but other exercises are also included as long as the training series meets the above criteria. The preferred time for applying the composition of the present invention will vary depending on the type and duration of exercise, but application is generally effective about 3 to 5 hours prior to exercise.

[0009] In the present invention, "sports requiring endurance" include, for example, marathons, middle and long distance running, middle and long distance swimming, road cycling, cross country, and long distance speed skating. In the present invention, "sports with weight restrictions" include, for example, judo, wrestling, boxing, etc. Also, weight management for maintaining an optimal weight is included in all sports.

[0010] In the present invention, the term "hardly digestible food ingredient" refers to a food ingredient that is not digested or is hardly digested and absorbed in the small intestine. In the present invention, "maltitol" refers to 4-O-α-D-glucopyranosyl-D-glucitol, also known as reduced maltose. In the present invention, "galactooligosaccharide" refers to 4'-galactosyl lactose. In the present invention, "glucomannan" refers to a polysaccharide in which glucose and mannose are linked in a straight chain via β-1,4-bonds in a ratio of approximately 2:3. The degree of polymerization of the glucomannan used in the present invention is not particularly limited.

[0011] In the present invention, "fructooligosaccharide" refers to a polysaccharide in which one or more D-fructose are further bonded to the fructose portion of sucrose (a sugar in which glucose and fructose are bonded via α-1,2-glycosidic bonds) via β-2,1-glycosidic bonds. The degree of polymerization of the fructooligosaccharide used in the present invention is not particularly limited. Examples of preferred fructooligosaccharides used in the present invention include kestose, nystose, and fructosylnystose.

[0012] In the present invention, "isomalto-oligosaccharide" refers to a polysaccharide having glucose as a basic unit and containing one or more α-1,6-bonds, α-1,4-bonds, and α-1,3-bonds. The degree of polymerization of the isomalto-oligosaccharide used in the present invention is not particularly limited. Preferred examples of the isomalto-oligosaccharide used in the present invention include isomaltose, isomaltotriose, and panose.

[0013] In the present invention, the "xylooligosaccharide" is a polysaccharide having a structure in which about 2 to 7 xylose units are linked via β-1,4-bonds. In the present invention, "pectin" refers to a complex polysaccharide mainly composed of polygalacturonic acid in which galacturonic acid is linked by α-1,4-bonds. The molecular weight of pectin that can be used in the present invention is not particularly limited.

[0014] In the present invention, "resistant starch" is a general term for starch and starch decomposition products that reach the large intestine without being digested in the human digestive tract up to the small intestine. Resistant starch (RS) is classified into four types based on its characteristics. Type 1 (RS1) is starch that is not acted upon by digestive enzymes such as α-amylase, such as grains with a low degree of refinement, type 2 (RS2) is starch with a high amylose content, type 3 (RS3) is retrograded starch whose structure changes during the cooling process after gelatinization by cooking, etc., and type 4 (RS4) is processed starch (chemically modified starch). Any type of resistant starch may be used in the present invention.

[0015] In the present invention, "resistant dextrin" refers to dietary fiber obtained by hydrolyzing starch at high temperature with the addition of a small amount of acid, and then hydrolyzing it with α-amylase and glucoamylase. Resistant dextrin is a glucan with an average molecular weight of about 2,000, and has α-1,2- and α-1,3-bonds in addition to the α-1,4- and α-1,6-bonds that starch naturally has, and has a more branched structure than the raw starch. Reduced resistant dextrin is resistant dextrin that has been subjected to a reduction treatment.

[0016] The amount of the indigestible food ingredients added to the composition of the present invention is not particularly limited, but since an excessively large amount may cause a side effect such as diarrhea, the indigestible food ingredients are preferably contained in an amount of 0.1% w / w to 20% w / w, preferably 0.5% w / w to 15% w / w, and more preferably 1% w / w to 10% w / w, based on the weight of the composition.

[0017] The weight ratio of each component of the resistant food component is not particularly limited and can be appropriately determined by a person skilled in the art. For example, each component of the resistant food component is preferably contained in a weight ratio of at least 0.5% or more, 1% or more, 5% or more, 10% or more, or 20% or more relative to the total weight of the resistant food component. Each component of the resistant food component may be contained in equal amounts relative to the total weight of the resistant food component, or may be contained in a different weight ratio.

[0018] The amount of each of the indigestible food ingredients to be added is not particularly limited, but if the amount is too large, there is a possibility of a side effect of diarrhea, so for example, the concentration of maltitol contained in the composition may be 0.1% w / w to 3% w / w, preferably 0.5% w / w to 2.5% w / w, 0.8% w / w to 1.5% w / w, the concentration of galactooligosaccharide contained in the composition may be 0.1% w / w to 3% w / w, preferably 0.5% w / w to 2.5% w / w, 0.8% w / w to 1.5% w / w, and the concentration of glucomannan contained in the composition may be 0.1% w / w to 2.5% w / w, preferably 0.1% w / w to 2.0% w / w. The above concentrations are concentrations relative to the weight of the composition.

[0019] The composition of the present invention is preferably a food or drink.The food or drink is not particularly limited as long as it is a food (including supplements) or drink, but more preferably is a dairy product.The dairy product is not particularly limited as long as it is a food or drink that uses raw milk or processed milk as a raw material, but in a preferred embodiment, the composition of the present invention is a milk drink.

[0020] In this specification, the term "milk beverage" refers to a beverage made from raw milk or processed milk to which non-milk-derived ingredients have been added. The milk beverage may further contain skim milk powder. The milk beverage may also contain, as added ingredients, ingredients that adjust the taste and aroma of the beverage, such as coffee, fruit juice, and flavorings, and nutrients such as vitamins and minerals.

[0021] The form of the composition of the present invention is not particularly limited as long as it is suitable for human ingestion, and may be, for example, a liquid, a suspension (dispersion), an emulsion, a semisolid, a paste, a powder, a granule, a tablet, a tablet, a capsule, or a pill. The composition of the present invention may also contain additives such as sweeteners, preservatives, colorants, antioxidants, or flavors.

[0022] The composition of the present invention is highly effective in promoting lipid metabolism during exercise. According to the composition of the present invention, lipid metabolism can be promoted preferentially over carbohydrate metabolism during exercise. The effect of the composition of the present invention can be confirmed by measuring the amount of fat oxidation and the amount of carbohydrate oxidation, which can be measured using a bicycle ergometer and an energy metabolism analyzer.

[0023] The composition of the present invention can be used in combination with exercise to promote lipid metabolism, reduce body fat, prevent or treat obesity, and prevent or treat metabolic syndrome. The composition of the present invention can also be used to preferentially remove fat rather than muscle during weight adjustment in athletes who are subject to weight restrictions. Furthermore, in endurance exercise, the composition of the present invention can use fat-derived energy in the early stages of the competition and conserve carbohydrate-derived energy in the latter stages, which is a key point, and is expected to improve performance. The effects of the composition of the present invention can be confirmed, for example, by a double-blind randomized crossover design (a study in which the same subjects are subjected to a test diet + exercise trial and a placebo + exercise trial with a 1-2 week rest period between them, and the effects are compared).

[0024] Hereinafter, preferred embodiments of the present invention will be described in detail. However, the following embodiments are merely examples of the present invention and are not intended to limit the scope of the present invention. [Example 1] Test for promoting lipid metabolism during exercise using the composition of the present invention method

[0025] <Subject> The subjects were eight healthy adult males (average age 25.6 years) who had no food allergies (milk) or severe lactose intolerance (they get diarrhea when they drink milk). 2 max (ml / kg / min) was determined. [Table 1] <Test meal> 200ml of milk containing resistant food ingredients (a mixture of 44% raw milk, 4.75% skim milk, 1.1% maltitol, 1.55% galactooligosaccharide, 0.11% glucomannan, 0.2% succinic acid monoglyceride, and 48.29% water) was used. 200ml of placebo drink (a mixture of 5% powdered sugar, 3.5% milk protein, 3% dextrin, 2.3% granulated sugar, 1.83% unsalted butter, 0.02% refined salt, 0.3% microcrystalline cellulose, 0.2% succinic acid monoglyceride, 0.02% milk flavor, and 83.83% water) was also used. The appearance, taste, and calories of both samples were adjusted to be almost the same, making a double-blind study possible. <Test Protocol> Two trials, exercise + placebo and exercise + milk with added resistant food ingredients, were conducted using a double-blind randomized crossover design (the same subjects drank the test food and placebo in different weeks for comparison). Exercise consisted of cycling at 75% VO 2The subjects pedaled a bicycle at 60 revolutions per minute for 60 minutes at maximum load. Four hours before each trial, they consumed 200 mL of a placebo drink or milk with added indigestible food ingredients. All meals were provided the night before, and for breakfast and lunch on the day of the trial. All intake of food other than water was restricted from 8:00 PM the night before until the end of the measurement at 9:00 AM the following morning. Measurements were performed in an artificial climate chamber at a room temperature of 21°C and humidity of 50%. Exhaled gas was collected at the following times: 5 minutes after starting to sit in a chair while at rest, and 3, 15, 30, 45, and 60 minutes after starting to exercise while exercising. Values ​​at each time point were calculated by averaging the values ​​measured from 1 minute before to 1 minute before each measurement point. Energy metabolism at rest and during exercise was measured by using the collected exhaled gas (oxygen intake (VO2) and carbon dioxide output (VCO2)) to automatically calculate the amount of lipid oxidation, carbohydrate oxidation (representing the amount of oxidation of polysaccharides such as starch and glycogen), glucose oxidation (representing the amount of oxidation of monosaccharides such as glucose), and respiratory exchange ratio using an energy metabolism analyzer (Aeromonitor AE-310S, Minato Medical Sciences, Japan). The respiratory exchange ratio can tell us the oxidation status of energy substrates in the body (whether fat or glucose was consumed). Results and Discussion

[0026] The results are shown in Figures 1 to 4. The amount of lipid oxidation 3 minutes after the start of exercise was 421±61 mg / min in the case of milk supplemented with resistant food ingredients, which was higher than the 263±86 mg / min in the case of placebo intake (Figure 1). On the other hand, the amount of carbohydrate oxidation (C) (amount of polysaccharide oxidation) 3 minutes after the start of exercise was 1257±148 mg / min in the case of milk supplemented with resistant food ingredients, and 1681±245 mg / min in the case of placebo intake (Figure 2). The amount of carbohydrate oxidation (G) (amount of glucose oxidation) was 1397±164 mg / min in the case of milk supplemented with resistant food ingredients, and 1868±272 mg / min in the case of placebo intake (Figure 3). Both the amount of carbohydrate oxidation (C) and the amount of carbohydrate oxidation (G) 3 minutes after the start of exercise tended to be lower in the case of milk supplemented with resistant food ingredients compared to the case of placebo intake. Regarding the respiratory exchange ratio, when the subjects consumed milk supplemented with indigestible food ingredients, the value was lower at the beginning of exercise compared to when the subjects consumed a placebo, indicating that fat metabolism was promoted (Figure 4). Furthermore, the total lipid oxidation amount after 60 minutes of exercise was evaluated by the area under the curve, and was 18,565 ± 2,129 when ingesting milk supplemented with resistant food ingredients, which was significantly higher than the 14,916 ± 2,282 when ingesting placebo. On the other hand, the area under the curve for carbohydrate oxidation amount was lower when ingesting milk supplemented with resistant food ingredients than when ingesting placebo for both carbohydrate oxidation amount (C) and carbohydrate oxidation amount (G), but no significant difference was observed between the two samples. These results show that the intake of milk supplemented with resistant food ingredients activates lipid metabolism in the early stage of exercise (0-15 minutes after the start), especially after 3 minutes, and that lipid metabolism is enhanced even after 60 minutes of exercise. In other words, even short exercise can promote fat consumption and have a dieting effect (application to diet foods), and it can also be applied to athletes in sports with weight restrictions, etc., to achieve favorable weight loss by preferentially removing fat rather than muscle during weight adjustment. In addition, athletes can use fat-derived energy in the early stages of a competition and conserve carbohydrate-derived energy such as glucose until the crucial second half of the competition, which is expected to improve their performance. Possible industrial applications

[0027] According to the composition of the present invention, a composition and method for promoting lipid metabolism during exercise can be provided. According to the composition of the present invention, lipid metabolism can be preferentially promoted during exercise, and therefore it can be preferably used for reducing body fat percentage. Therefore, when the composition of the present invention is combined with short-term exercise, weight loss can be achieved without difficulty, and it can be used for the prevention or treatment of obesity or metabolic syndrome. The composition of the present invention can preferentially remove fat rather than muscle during weight adjustment, even for athletes with weight restrictions. Furthermore, in sports requiring endurance, the composition of the present invention can be expected to improve performance, since it uses fat-derived energy in the early stages of the game and conserves carbohydrate-derived energy for the latter stages of the game.

Claims

1. A composition for promoting lipid metabolism during exercise, comprising, as an active ingredient, a non-digestible food ingredient including maltitol, galactooligosaccharide, and glucomannan, Here, the exercise is performed at a load of 70 to 80% of the maximum oxygen intake VO2 max. The composition.

2. The composition according to claim 1, wherein the non-digestible food ingredient is present in an amount of from 0.1% w / w to 20% w / w of the composition.

3. The composition according to claim 1 or 2, wherein when the composition is ingested, the amount of fat oxidation during exercise is increased and / or the amount of carbohydrate oxidation is decreased compared to when the composition is not ingested.

4. The composition according to any one of claims 1 to 3, wherein the composition is a food or drink.

5. The composition according to claim 4 , wherein the food or beverage is a dairy product.

6. The composition of claim 5 , wherein the dairy product is a dairy drink.

7. The composition according to any one of claims 1 to 6, which is applied 3 to 5 hours before exercise.

8. The composition according to any one of claims 1 to 7, for use in the prevention or treatment of obesity or metabolic syndrome.

9. The composition according to any one of claims 1 to 7, which is applied to athletes in endurance sports or sports with weight restrictions.

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