Kit and beauty method using microneedle sheet

Abstract

To provide a kit which can prohibit a repeated use of a microneedle, and can easily and sanitarily use cosmetics.SOLUTION: A kit comprises: a microneedle sheet having a base material layer, and a plurality of microneedles including water-soluble or water-dispersible polymers on the base material layer; and a device having at least one applicator 2-3 having an application face, a vessel 2-1 including a cosmetic composition, and a valve 2-2. The microneedle sheet can be attached to the applicator by attaching the base material layer of the microneedle sheet to the application face of the applicator. The applicator, the vessel and the valve are constituted so as to supply the cosmetic compositions on the microneedle sheet attached to the applicator via the valve, and the valve controls the supply of the cosmetic compositions on the microneedle sheet attached to the applicator.SELECTED DRAWING: Figure 3

Description

[Technical field]

[0001] The present invention relates to a kit comprising at least one microneedle sheet comprising a plurality of microneedles, and a cosmetic method for keratinous materials such as the skin, lips and scalp using the microneedle sheet. [Background technology]

[0002] The stratum corneum (SC) constitutes the main barrier for exogenous substances, including low molecular weight materials. In general, exogenous substances that penetrate the skin must diffuse through the highly organized intercellular lipid bilayer of the stratum corneum. This intercellular micropathway, which is lipophilic, is the primary route by which exogenous substances pass the SC barrier by passive diffusion along the concentration gradient between the delivery vehicle and the SC. Some exogenous substances have difficulty penetrating the skin.

[0003] To deliver exogenous substances deeper into the skin, injections can be performed using conventional needles, however such injections cause pain and must be performed by a professional such as a doctor, and therefore injections using conventional needles are not commonly used for cosmetic purposes.

[0004] The idea of ​​using a microstructured device with multiple microneedles to break the stratum corneum (SC) barrier was first proposed in the 1970s.A variety of devices have been developed that contain solid microneedles to provide a system that can pierce the stratum corneum and leave microscopic holes, allowing subsequent drug delivery inwards or interstitial fluid to pass outwards.The manufacture of solid microprojections and microneedle arrays, for example using silicone or insoluble polymers, has been described in the art, for example in WO2009040548 and US2015 / 0141910.

[0005] However, these insoluble microneedles remain sharp and intact after application, which leaves a high risk of cross-contamination due to repeated use of the microneedles.

[0006] Furthermore, when cosmetics are used in combination with the use of such systems currently known in the art, the cosmetics must be applied onto the skin by hand, which may not be easy or hygienic. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] International Publication No. 2009040548 [Patent Document 2] US Patent Application Publication No. 2015 / 0141910 [Patent Document 3] U.S. Patent No. 6,219,574 [Patent Document 4] Canadian Patent Application No. 2226718 [Patent Document 5] U.S. Patent No. 6,652,478 [Non-patent literature]

[0008] [Non-Patent Document 1] Walter Noll, Chemistry and Technology of Silicones (1968), Academic Press [Non-Patent Document 2] Cosmetics and Toiletries, Vol. 91, January 1976, pp. 27-32, Todd & Byers, "Volatile Silicone Fluids for Cosmetics" [Non-Patent Document 3] ASTM Standard 445 Appendix C Summary of the Invention [Problem to be solved by the invention]

[0009] An object of the present invention is to provide a kit that can prevent repeated use of microneedles and allows cosmetics to be applied easily and hygienically, and a beauty method in which the kit can be used. [Means for solving the problem]

[0010] The above objectives are: A substrate layer, and A plurality of microneedles comprising at least one water-soluble or water-dispersible polymer on a substrate layer. At least one microneedle sheet comprising: at least one applicator having at least one application surface; At least one container containing at least one cosmetic composition; and At least one valve At least one device with A kit, preferably a cosmetic kit for keratin materials, more preferably a cosmetic kit for the skin, lips or scalp, comprising: The microneedle sheet can be attached to the applicator by attaching a substrate layer of the microneedle sheet to an application surface of the applicator; an applicator, a reservoir and a valve adapted to deliver a cosmetic composition through the valve onto a microneedle sheet attached to the applicator; The valve is capable of controlling the delivery of the cosmetic composition onto the microneedle sheet attached to the applicator. This can be achieved by means of a kit.

[0011] It is preferable that the substrate layer of the microneedle sheet is removable from the application surface of the applicator after it has been attached to the application surface of the applicator.

[0012] The microneedle sheet may comprise at least one base layer which may be fixed onto a substrate layer.

[0013] The microneedle sheet may comprise at least one adhesive layer which, if present, may be fixed onto the substrate layer or onto the base layer.

[0014] The microneedle sheet may include at least one release layer which may be disposed on the adhesive layer.

[0015] The microneedles may have a height of 50 to 1000 microns, preferably 100 to 750 microns, more preferably 150 to 500 microns.

[0016] The application surface of the applicator may be curved. The applicator may comprise at least one cylindrical roller having a curved side, and the curved side of the cylindrical roller may comprise the application surface.

[0017] The kit according to the present invention may further include at least one storage section, which is capable of storing the microneedle sheet.

[0018] The reservoir may comprise at least one soft and / or porous article selected from a sponge, a woven fabric, a non-woven fabric, and combinations thereof.

[0019] Preferably, the valve is a gate valve.

[0020] It is preferred that the cosmetic composition comprises at least one cosmetic active ingredient.

[0021] The present invention also provides a cosmetic method for treating keratinous materials such as the skin, lips and scalp, comprising the steps of: Attaching at least one microneedle sheet to at least one applicator having at least one application surface by attaching a substrate layer of the microneedle sheet to the application surface of the applicator, The microneedle sheet comprises a base layer and a plurality of microneedles on the base layer, the microneedles including at least one water-soluble or water-dispersible polymer; The applicator is provided in at least one device having at least one container containing at least one cosmetic composition and at least one valve; The process and applying an applicator onto the keratinous material such that the microneedles contact the keratinous material; an applicator, a reservoir and a valve adapted to deliver a cosmetic composition through the valve onto a microneedle sheet attached to the applicator; a valve capable of controlling delivery of the cosmetic composition onto a microneedle sheet attached to the applicator; A cosmetic composition is provided on the microneedle sheet during the step of applying the applicator onto the keratinous material; Process and The present invention also relates to a cosmetic method including:

[0022] The cosmetic method according to the present invention may further include a step of applying the applicator onto keratinous material without supplying a cosmetic composition onto the microneedle sheet on the application surface of the applicator. [Brief description of the drawings]

[0023] [Figure 1] FIG. 2 is a cross-sectional view of an example of a microneedle sheet used for the present invention. [Diagram 2] FIG. 1 is a perspective view of an example of a device comprising at least one applicator, at least one container, and at least one valve. [Diagram 3] Schematic diagram of the device with the valve in the "ON" and "OFF" positions. [Figure 4] FIG. 1 is a perspective view of a device having a microneedle sheet. [Diagram 5] A perspective view of how to use a device with a microneedle sheet. [Figure 6] FIG. 2 is a cross-sectional view of an example of a storage section that can be used for the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0024] As a result of extensive investigation, the present inventors have discovered that it is possible to provide a kit that can prevent repeated use of microneedles and allows for easy and hygienic application of cosmetics.

[0025] The present invention uses a disposable microneedle sheet with water-soluble or water-dispersible microneedles, not a reusable microneedle with insoluble microneedles.Therefore, in the first use, the microneedles can be deformed, for example, by being dissolved or absorbed in keratin material and / or in the cosmetic on keratin material.Therefore, the used microneedle sheet needs to be replaced with a new one after one use.Therefore, the repeated use of microneedles can be prevented.

[0026] The present invention also uses a device that can supply a controlled amount of cosmetic composition onto a microneedle sheet. The cosmetic composition supplied onto the microneedle sheet can be applied onto keratinous materials through the surface of the microneedle sheet. Therefore, the cosmetic composition can be easily and hygienically applied onto keratinous materials.

[0027] Since the cosmetic composition can be applied onto keratinous materials such as skin, lips and scalp in combination with the microneedle sheet, the cosmetic composition can penetrate into the keratinous materials relatively easily through the holes / holes formed thereon by the microneedles of the microneedle sheet, compared to the case without the microneedle sheet. Therefore, the present invention can allow the cosmetic composition to penetrate much deeper into the keratinous materials, and can deliver a relatively large amount of the cosmetic composition into the keratinous materials, compared to the case without the microneedle sheet.

[0028] Therefore, one aspect of the present invention is A substrate layer, and A plurality of microneedles comprising at least one water-soluble or water-dispersible polymer on a substrate layer. At least one microneedle sheet comprising: at least one applicator having at least one application surface; At least one container containing at least one cosmetic composition; and At least one valve At least one device with A kit comprising: The microneedle sheet can be attached to the applicator by attaching the substrate layer of the microneedle sheet to the application surface of the applicator. The applicator, the container, and the valve are configured to deliver a cosmetic composition through the valve onto a microneedle sheet attached to the applicator; The valve is capable of controlling the delivery of the cosmetic composition onto the microneedle sheet attached to the applicator. It's a kit.

[0029] Another aspect of the present invention is a cosmetic method for keratinous materials such as the skin, lips and scalp, comprising the steps of: Attaching at least one microneedle sheet to at least one applicator having at least one application surface by attaching a substrate layer of the microneedle sheet to the application surface of the applicator, The microneedle sheet comprises a base layer and a plurality of microneedles on the base layer, the microneedles including at least one water-soluble or water-dispersible polymer; The applicator is provided in at least one device having at least one container containing at least one cosmetic composition and at least one valve; The process and applying an applicator onto the keratinous material such that the microneedles contact the keratinous material; The applicator, the container, and the valve are configured to deliver a cosmetic composition through the valve onto a microneedle sheet attached to the applicator; A valve is capable of controlling delivery of the cosmetic composition onto a microneedle sheet attached to the applicator; A cosmetic composition is provided on the microneedle sheet during the step of applying the applicator onto the keratinous material; Process and Including, It is a beauty method.

[0030] The kit and cosmetic method according to the present invention can prevent repeated use of microneedles, and can make it possible to apply cosmetics easily and hygienically.

[0031] When the applicator is in the form of a cylindrical roller, the cosmetic composition can be continuously and quantitatively applied onto the keratinous material, such as the skin, lips, and scalp, by rotating the applicator on the keratinous material. In addition, by rotating the applicator on the keratinous material, the cosmetic composition is likely to form a uniform cosmetic film on the keratinous material, such as the skin, lips, and scalp.

[0032] According to the present invention, the microneedle sheet is separated from the applicator when not in use. The microneedle sheet can be attached to the applicator when in use. Thus, it is easy for the user to store the applicator without breaking the microneedles.

[0033] It is preferable that the substrate layer of the microneedle sheet is removable from the application surface of the applicator after being attached to the application surface of the applicator. In this case, the applicator can be used repeatedly by replacing the microneedle sheet on the applicator. The replacement of the microneedle sheet can be performed by the user.

[0034] When the kit according to the present invention further comprises at least one storage section in which the microneedle sheet can be stored, it becomes easier to store the microneedle sheet without breaking the microneedles.

[0035] The present invention can provide a cosmetic treatment without pain, since the microneedles do not cause any pain, so the kit according to the present invention is convenient for cosmetic or non-therapeutic treatment.

[0036] Hereinafter, the kit and the cosmetic method according to the present invention will be described in more detail.

[0037] [kit] The kit according to the invention, preferably a cosmetic kit for keratinous materials, more preferably a cosmetic kit for the skin, lips or scalp, comprises: A substrate layer, and A plurality of microneedles comprising at least one water-soluble or water-dispersible polymer on a substrate layer. At least one microneedle sheet comprising: at least one applicator having at least one application surface; and At least one container containing at least one cosmetic composition; and At least one valve At least one device with Equipped with The microneedle sheet can be attached to the applicator by attaching a substrate layer of the microneedle sheet to an application surface of the applicator; the applicator, the reservoir and the valve are configured to deliver a cosmetic composition through the valve onto a microneedle sheet attached to the applicator; The valve is capable of controlling the delivery of the cosmetic composition onto a microneedle sheet attached to the applicator.

[0038] The kit according to the invention can be used for the cosmetic treatment of keratinous materials.

[0039] {Microneedle sheet} The microneedle sheet used for the kit according to the present invention comprises a base layer and a plurality of microneedles comprising at least one water-soluble or water-dispersible polymer on the base layer.

[0040] The microneedle sheet used for the present invention can be attached to the applicator of the device described later.

[0041] The microneedle sheet used for the present invention is disposable. After one use, the microneedle sheet is replaced with a new one.

[0042] (Microneedle) The microneedle sheet used for the present invention comprises a plurality of microneedles.

[0043] The microneedles are present on the surface of the base layer. The microneedles may be present on 50% or more, preferably 70% or more, more preferably 90% or more of the surface of the base layer.

[0044] Preferably, the microneedles are present on one of the surfaces of the backing layer.

[0045] The microneedles of the microneedle sheet used for the present invention are preferably designed to penetrate or enter the stratum corneum of the skin, in particular of the facial skin, as well as of the lips or scalp.

[0046] The microneedles can be of any size and shape suitable for penetrating the stratum corneum. It may be preferred that the microneedles are designed to traverse through the stratum corneum. The microneedles may be capable of creating openings in the stratum corneum.

[0047] If necessary, the height of the microneedles may be varied to allow penetration into the epidermis and / or dermis of the skin, preferably into the upper dermis, and more preferably into the lower dermis.

[0048] The shape of the microneedle is not limited as long as it is a "needle". It is clear to those skilled in the art that the microneedle for the present invention can have any reasonable shape, including but not limited to cone-shaped, rod-shaped and / or column-shaped. As such, the microneedle may have the same diameter at the tip as at the base, or may taper in diameter from the base to the tip.

[0049] For example, the shape of the microneedle may be in the form of a triangular, square or pentagonal pyramid, or the microneedle may be in the form of a cylinder, preferably with a tip which may be formed by bevelling the cylinder.

[0050] The cross-section of the microneedles can take any geometric shape including circular, triangular, square, rectangular, polygonal, regular or irregular shapes, etc. In one embodiment, the population of microneedles may take the form of hollow microcapillaries.

[0051] Therefore, "microneedles" are referred to as one type of microprojection or microprotrusion that is being utilized. In many cases, those skilled in the art will understand that the same inventive principles apply to the use of other microprojections or microprotrusions to penetrate the skin. Other microprojections or microprotrusions include, for example, microblades as described in U.S. Patent No. 6,219,574 and Canadian Patent Application No. 2,226,718, and edged microneedles as described in U.S. Patent No. 6,652,478.

[0052] The height or length of the microneedles of the microneedle sheet used in the present invention may be 50 to 1000 microns, preferably 100 to 750 microns, and more preferably 150 to 500 microns.

[0053] According to one embodiment of the present invention, the microneedle is in the form of a cone.

[0054] The cone may have a distal end, such as a tip and a base. The base may be circular or elliptical in shape.

[0055] The height or length of the cones of the microneedles of the microneedle sheet used for the present invention may be 50 to 1000 microns, preferably 100 to 750 microns, more preferably 150 to 500 microns.

[0056] The conical base of the microneedles of the microneedle sheet used for the present invention may have a diameter or width of 50 to 350 microns, preferably 100 to 300 microns, more preferably 150 to 250 microns. When the conical base of the microneedles of the microneedle sheet used for the present invention is in the shape of an ellipse or oval, the length or width of the main axis of the ellipse may be 50 to 350 microns, preferably 100 to 300 microns, more preferably 150 to 250 microns.

[0057] The microneedles may have an aspect ratio (length / width at base) of at least about 3: 1, at least about 2: 1, or at least about 1: 1. The ratio of the (height of the cone) / (diameter at the base of the cone) of the microneedle may be 1 or greater, preferably 1.5 or greater, and more preferably 2.0 or greater.

[0058] Preferably, the microneedle has a resistance of 50.0 N / cm 2 Less than, for example, 20.0N / cm 2 Less than, for example, 10N / cm 2 When an insertion pressure of less than 1000 psi is applied along the length of the microneedle, it will not break under the force.

[0059] It is also preferred that the microneedle sheets used for the present invention, and in particular the microneedles of the microneedle sheets, have a Young's modulus of 50 N / mm or more, preferably 55 N / mm or more, more preferably 60 N / mm or more.

[0060] It may be preferred that the microneedles are capable of penetrating into keratinous materials such as the skin, lips and scalp to a depth of 200 microns or less, preferably 180 microns or less, more preferably 160 microns or less.

[0061] The microneedles are soluble. By "soluble" it is meant that the microneedles can be dissolved (broken or disintegrated) in a cosmetic composition, which may preferably contain water, and / or can be dissolved in keratinous materials such as the skin, lips and scalp, for example by natural moisturizing factors or internal / external moisture.

[0062] The microneedles of the microneedle sheet used for the present invention may comprise at least one water-soluble or water-dispersible polymer. Here, the terms "water-soluble" and "water-dispersible" mean that it is soluble and dispersible, respectively, when it contacts with water. A single water-soluble or water-dispersible polymer may be used. Two or more water-soluble or water-dispersible polymers may be used in combination.

[0063] It is preferred that the water-soluble or water-dispersible polymer is soluble or dispersible in the skin, lips or scalp.Therefore, in one embodiment of the present invention, the water-soluble or water-dispersible polymer can be dissolved or dispersed after being inserted into keratinous materials such as the skin, lips and scalp.Due to the solubility or dispersibility of the polymer, the microneedles of the microneedle sheet used for the present invention can effectively release the agent when present in the microneedle.Optional external water combined with the application of the microneedle sheet can be used to promote the dissolution or dispersion of the microneedle.

[0064] It is preferred that the water-soluble or water-dispersible polymer is soluble in the surface layers of keratinous materials such as the skin, lips and scalp.

[0065] The water-soluble or water-dispersible polymer may be selected from hyaluronic acid (particularly low molecular weight hyaluronic acid), monosaccharides, disaccharides, oligosaccharides, polysaccharides (including derivatives thereof, such as hydroxymethylcellulose), dextrins, dextran, polyethylene glycol, polyvinyl alcohol, poly(methyl vinyl ether / maleic anhydride), polyvinylpyrrolidone, poly(methyl / vinyl ether / maleic acid) (PMVE / MA) and esters thereof, poly(methyl / vinyl ether / maleic anhydride) (PMVE / MAH), salts thereof, and mixtures thereof.

[0066] The water-soluble or water-dispersible polymer may have a molecular weight of from 10,000 to 200,000 daltons, preferably from 30,000 to 150,000 daltons, and more preferably from 50,000 to 100,000 daltons.

[0067] The low molecular weight hyaluronic acid may have a molecular weight of 100 kDa or less, preferably 70 kDa or less, more preferably 50 kDa or less.

[0068] The polyvinylpyrrolidone may have a molecular weight between 1 kDa and 300 kDa, preferably between 5 kDa and 200 kDa, more preferably between 7 kDa and 100 kDa.

[0069] Poly(methyl / vinyl ether / maleic acid) (PMVE / MA) and its esters, as well as poly(methyl / vinyl ether / maleic anhydride) (PMVE / MAH), are known as Gantrez-type polymers.

[0070] The amount (solid basis) of the water-soluble or water-dispersible polymer in the microneedles of the microneedle sheet used for the present invention may be 50% by mass or more, preferably 60% by mass or more, more preferably 70% by mass or more, based on the total mass of the microneedles. The amount (solid basis) of the water-soluble or water-dispersible polymer in the microneedles of the microneedle sheet used for the present invention may be 100% by mass or less, preferably 90% by mass or less, more preferably 80% by mass or less, based on the total mass of the microneedles. Therefore, the amount (solid basis) of the water-soluble or water-dispersible polymer in the microneedles of the microneedle sheet used for the present invention may be 50% by mass to 100% by mass, preferably 60% by mass to 90% by mass, more preferably 70% by mass to 80% by mass, based on the total mass of the microneedles.

[0071] It may be possible that the microneedles of the microneedle sheet used for the present invention comprise at least one material that is swellable, more preferably water-swellable, even more preferably swellable in keratinous materials such as the skin, lips and scalp. The material may be a polymer that is swellable, more preferably water-swellable, even more preferably swellable in keratinous materials. Here, the term "water-swellable" means that it is swellable when contacted with water. The swellable material or polymer may have a high swelling capacity such that it can swell at least 10 times more in 1 hour of in vitro incubation in saline solution or phosphate buffered saline, preferably at least 20 times in 1 hour of incubation, more preferably at least 30 times in 1 hour of incubation, even more preferably at least 40 times in 1 hour of incubation, and most preferably about 45 to 55 times in 1 hour of incubation.

[0072] It may be preferred that at least the distal end portion of the microneedle swells at least twice as large upon insertion into the keratinous material, more preferably within less than 1 hour after insertion into the keratinous material, and even more preferably within 24 hours.

[0073] The swellable material, preferably the swellable polymer, may have high viscoelasticity so that it can form a gel after in vitro incubation in saline solution or phosphate buffered saline. The gel has a high elastic modulus G', a high viscous modulus G", a tangent (δ) of less than 1 (tangent (δ) = G" / G') and a high consistency G* (G*) even at low frequencies (0.01 Hz) in a dynamic frequency sweep test using a rheometer. 2 =G' 2 +G" 2 ) is shown.

[0074] In one embodiment, the swellable material, preferably the swellable polymer, is not water soluble or water dispersible.

[0075] In another embodiment, the swellable material, preferably a swellable polymer, can be a hydrogel-forming polymer.

[0076] The swellable polymer may be selected from high molecular weight hyaluronic acid, crosslinked hyaluronic acid, crosslinked polyethylene glycol, polyethylene glycol crosslinked polylactic acid or polyglycolic acid or poly-lactic acid-co-glycolic acid or polydioxanone, poly(styrene)-block-poly(acrylic acid), polyethylene glycol crosslinked PMVE / MA, crosslinked polyvinylpyrrolidone, sodium starch glycolate; cellulose; natural and synthetic gums; alginates; sodium polyacrylate, PEG crosslinked poly(methyl / vinyl ether / maleic acid) (PMVE / MA) and esters thereof, PEG crosslinked poly(methyl / vinyl ether / maleic anhydride) (PMVE / MAH) and esters thereof, salts thereof, and mixtures thereof.

[0077] High molecular weight hyaluronic acid may have a molecular weight of more than 500 kDa, preferably more than 1000 kDa, more preferably more than 2100 kDa, and preferably less than 10000 kDa.

[0078] Unless otherwise defined, molecular weight herein refers to number average molecular weight.

[0079] Poly(methyl / vinyl ether / maleic acid) (PMVE / MA) and its esters, as well as poly(methyl / vinyl ether / maleic anhydride) (PMVE / MAH), are known as Gantrez-type polymers.

[0080] The amount of swelling material (solid basis) in the microneedles of the microneedle sheet used for the present invention may be 1% by mass or more, preferably 5% by mass or more, more preferably 10% by mass or more, based on the total mass of the microneedles. The amount of swelling material (solid basis) in the microneedles of the microneedle sheet used for the present invention may be 30% by mass or less, preferably 25% by mass or less, more preferably 20% by mass or less, based on the total mass of the microneedles. Therefore, the amount of swelling material (solid basis) in the microneedles of the microneedle sheet used for the present invention may be 1% by mass to 30% by mass, preferably 5% by mass to 25% by mass, more preferably 10% by mass to 20% by mass, based on the total mass of the microneedles.

[0081] When the microneedles of the microneedle sheet used for the present invention comprise at least one swellable material, preferably at least one swellable polymer, the microneedles may be swellable such that they can improve the aesthetic appearance of keratinous materials, preferably skin, more preferably facial skin, by reducing the appearance of wrinkles.

[0082] In other words, if the microneedle is swellable, it can swell within the skin, for example with its absorption of water within the skin, further increasing the volume of the microneedle. Such volume expansion beneath the skin surface at the wrinkle site can effectively push the wrinkle from within the skin, causing the wrinkle to become shallower and wider. Thus, the wrinkle can be reduced or made less noticeable.

[0083] The tip separation distance between each of the individual microneedles on the backing layer can be varied to ensure penetration of the skin, lips or scalp by the microneedles while at the same time providing a separation distance short enough to provide a high transdermal transport rate.

[0084] In one embodiment, the tip separation distance between the microneedles may range from 10 to 1000 μm, such as 30 to 800 μm or 50 to 600 μm, etc. This may allow a compromise to be achieved between effective penetration of the stratum corneum by as many microneedles as possible and the room required for possible swelling of the microneedles, if they are swellable.

[0085] In one embodiment, the density of the microneedles is between 100 and 2000 microneedles / cm 2 , preferably 200 to 1000 microneedles / cm 2 , and even more preferably 200 to 500 microneedles / cm 2 It may be.

[0086] (Polyol) According to one embodiment, at least one of the microneedles of the microneedle sheet may comprise at least one polyol. A single type of polyol may be used. Two or more types of polyols may be used in combination.

[0087] The polyol is heated at atmospheric pressure (760 mmHg or 10 5 It is preferred that the polymer is in the form of a liquid at room temperature, such as 25° C., under 100 Pa.

[0088] The term "polyol" as used herein means an alcohol having two or more hydroxyl groups and does not include sugars or their derivatives. Derivatives of sugars include sugar alcohols obtained by reducing one or more carbonyl groups of a sugar, as well as sugars or sugar alcohols in which one or more hydrogen atoms in one or more of their hydroxyl groups have been replaced with at least one substituent, such as an alkyl group, a hydroxyalkyl group, an alkoxy group, an acyl group or a carbonyl group.

[0089] The polyols used in the present invention are liquid at room temperature, such as 25° C., under atmospheric pressure (760 mmHg or 105 Pa).

[0090] The polyol is a C2-C hydroxyl group containing at least two hydroxyl groups, preferably 2 to 5 hydroxyl groups. 24 It may be a polyol, preferably a C2 to C9 polyol.

[0091] The polyol may be a natural or synthetic polyol. The polyol may have a linear, branched or cyclic molecular structure.

[0092] The polyol can be selected from glycerin and its derivatives, and glycols and its derivatives. The polyol can be selected from glycerin, diglycerin, polyglycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, C6-C 24 It may be selected from the group consisting of polyethylene glycol, 1,3-propanediol, 1,4-butanediol and 1,5-pentanediol.

[0093] When the microneedles of the microneedle sheet comprise a polyol, the brittleness of the microneedles may be reduced or controlled.

[0094] (sugar) According to one embodiment, at least one of the microneedles of the microneedle sheet may comprise at least one sugar or a derivative thereof. A single type of sugar or a derivative thereof may be used. Two or more sugars, their derivatives, or a combination of sugars and their derivatives may be used.

[0095] The term "sugar" as used herein means a polyalcohol that contains one or more carbohydrate units and may have at least one carbonyl group. Derivatives of sugars include sugar alcohols obtained by reducing one or more carbonyl groups of a sugar, as well as sugars or sugar alcohols in which one or more hydrogen atoms in one or more of their hydroxy groups have been replaced with at least one substituent, such as an alkyl group, a hydroxyalkyl group, an alkoxy group, an acyl group or a carbonyl group.

[0096] The sugar may be selected from the group consisting of monosaccharides, oligosaccharides, polysaccharides, and mixtures thereof.

[0097] The monosaccharide may be selected from the group consisting of glucose, fructose, galactose, mannose, talose, sorbose, xylose, lyxose, fucose, arabinose, rhamnose, ribose, ribulose, xylulose, sorbitol, triose, pentose, hexose, ketose, glucosamine, and mixtures thereof.

[0098] The oligosaccharides may be selected from the group consisting of maltose, lactose, saccharose, cellobiose, trehalose, sucrose, fructo-oligosaccharides, dextrins, and mixtures thereof. Preferred oligosaccharides may consist of 2 to 10 monosaccharides.

[0099] The polysaccharide may be selected from alginic acid, guar gum, xanthan gum, gum arabic, arabinogalactan, carrageenan, agar, karaya gum, tragacanth gum, tara gum, pectin, locust bean gum, curdlan, gellan gum, dextran, pullulan, hyaluronic acid, cellulose and its derivatives, and mixtures thereof.

[0100] The sugar derivatives may be selected from the group consisting of erythritol, lactitol, maltitol, mannitol, sorbitol and xylitol, in which at least one hydrogen in the hydroxyl group may be replaced with at least one substituent such as an alkyl group, a hydroxyalkyl group, an alkoxy group, an acyl group or a carbonyl group.

[0101] The above sugars can exist in the L or D isomeric form.

[0102] (beauty active ingredient) According to one embodiment, at least one of the microneedles of the microneedle sheet used for the present invention may contain at least one cosmetically active ingredient. A single cosmetically active ingredient may be used. Two or more cosmetically active ingredients may be used in combination.

[0103] The type of cosmetic active is not limited. The cosmetic active may be selected from the group consisting of anti-aging agents, whitening agents, anti-wrinkle agents, antiperspirants, cooling agents, cleansing agents, skin texture treatment agents, and combinations thereof.

[0104] For example, anti-aging agents can be used as cosmetic active ingredients.

[0105] Examples of anti-aging agents include antioxidants, moisturizers, free radical scavengers, keratolytic agents, such as alpha or beta-hydroxy acids, vitamins, such as vitamin C and its derivatives and vitamin E and its derivatives, anti-elastase and anti-collagenase agents, protides, fatty acid derivatives, steroids, trace elements, bleaching agents, vegetable oils, such as almond oil, extracts of algae and plankton, hyaluronic acid or its salts, such as sodium hyaluronate, enzymes and coenzymes, flavonoids, ceramides, and mixtures thereof.

[0106] The amount of cosmetically active ingredient in the microneedles of the microneedle sheet used in the present invention is not limited, and may be 0.01% by mass to 10% by mass, preferably 0.05% by mass to 5% by mass, and more preferably 0.1% by mass to 1% by mass, relative to the total mass of the microneedles.

[0107] It is also possible that the amount of cosmetically active ingredient in the microneedles of the microneedle sheet used for the present invention is less than 0.01% by weight, based on the total weight of the microneedles. In one embodiment, the microneedles of the microneedle sheet according to the present invention may not contain any cosmetically active ingredient.

[0108] (base material layer) The microneedle sheet used for the present invention comprises a substrate layer on which the microneedles reside or are disposed.

[0109] The substrate layer of the microneedle sheet used for the present invention may be either soluble or non-soluble.

[0110] It is preferable that the substrate layer of the microneedle sheet used for the present invention is soluble in water or disintegrable in water.

[0111] The substrate layer of the microneedle sheet used for the present invention may contain at least one water-soluble or water-dispersible polymer described above. In other words, the above description of the water-soluble or water-dispersible polymer that may be contained in the microneedles of the microneedle sheet can be applied to the water-soluble or water-dispersible polymer that may be contained in the substrate layer.

[0112] For example, the amount of water-soluble or water-dispersible polymer (solid basis) in the substrate layer of the microneedle sheet used for the present invention may be 50% by mass or more, preferably 60% by mass or more, more preferably 70% by mass or more, based on the total mass of the substrate layer. The amount of water-soluble or water-dispersible polymer (solid basis) in the substrate layer of the microneedle sheet used for the present invention may be 100% by mass or less, preferably 90% by mass or less, more preferably 80% by mass or less, based on the total mass of the substrate layer. Therefore, the amount of water-soluble or water-dispersible polymer (solid basis) in the substrate layer of the microneedle sheet used for the present invention may be 50% by mass to 100% by mass, preferably 60% by mass to 90% by mass, more preferably 70% by mass to 80% by mass, based on the total mass of the substrate layer.

[0113] The backing layer and the microneedles may or may not be integral.

[0114] When the substrate layer and the microneedles are integrated, the substrate layer and the microneedles may comprise at least one common water-soluble or water-dispersible polymer.

[0115] Therefore, in one embodiment, the substrate layer and the microneedles can be a single component that includes at least one common water-soluble or water-dispersible polymer, and preferably, the single component can be prepared by using the same water-soluble or water-dispersible polymer.

[0116] On the other hand, if the substrate layer and the microneedles are not integrated, ie, the substrate layer is different or separate from the microneedles, then the substrate layer and the microneedles may be made from different materials.

[0117] Thus, in another embodiment, the backing layer and the microneedles may be an assembly of two different or separate elements.

[0118] In the latter embodiment, the substrate layer may be made, for example, from a fiber or a polymeric film.

[0119] The fibers can be made from natural fibers such as cotton, semi-natural fibers such as viscose, synthetic fibers such as polyester and polypropylene fibers, and combinations thereof. The porous underlayer can be selected from woven or non-woven fabrics.

[0120] The polymeric film can be made from synthetic resins such as polyurethane, polystyrene, polycarbonate, polyethylene terephthalate, poly(ethylene-co-vinyl alcohol), polyethylene, polyester, polyamide, and combinations thereof.

[0121] The substrate layer can be cut into the form of a patch, disc, mask, towel, glove, pre-cut roll, or any other form suitable for cosmetic use.

[0122] (additional layer) The microneedle sheet used for the present invention may comprise at least one additional layer.

[0123] In one embodiment, the microneedle sheet comprises at least one base layer as an additional layer, and the base layer is fixed on the base layer.For fixing, any means can be used to firmly attach the base layer on the base layer.For example, any adhesive can be used to fix the base layer on the base layer.

[0124] The form and material of the underlayer are not limited.

[0125] The underlay may be a porous or a non-porous underlay.

[0126] The porous base layer may be made of fibers. The fibers may be made of natural fibers such as cotton, semi-natural fibers such as viscose, synthetic fibers such as polyester and polypropylene fibers, and combinations thereof. The porous base layer may be selected from woven or non-woven fabrics.

[0127] The non-porous base layer may be comprised of a polymer film, which may be made from synthetic resins such as polyurethane, polystyrene, polycarbonate, polyethylene terephthalate, poly(ethylene-co-vinyl alcohol), polyethylene, polyester, polyamide, and combinations thereof.

[0128] If the microneedles and the substrate layer of the microneedle sheet are different or separate elements, the substrate layer may function as the base layer, and thus in this case a base layer may not be required.

[0129] In one embodiment, the microneedle sheet comprises at least one adhesive layer as an additional layer, which, if present, is fixed onto the substrate layer or onto the base layer.

[0130] The material of the adhesive layer is not limited. It is preferable to use an adhesive layer that can be removed from the application surface of the applicator. For example, it is preferable to use an adhesive layer that can be peeled or removed from the application surface of the applicator.

[0131] It may be preferable to use a pressure-sensitive adhesive to form the adhesive layer. Any conventional pressure-sensitive adhesive can be used as the pressure-sensitive adhesive. The pressure-sensitive adhesive can include at least one adhesive polymer. The adhesive polymer can be selected from the group consisting of (meth)acrylate polymers, acetate-vinyl acrylate copolymers, copolymers containing polyisobutylene, polystyrene or polybutadiene, rosin-based resins, polyterpene resins, petroleum-based resins, terpene phenolic resins, silicone resins, natural or synthetic rubbers, and mixtures thereof.

[0132] In one embodiment, the microneedle sheet comprises at least one release layer as an additional layer, the release layer being disposed on the adhesive layer.

[0133] The release layer can protect the adhesive layer.

[0134] The material of the release layer is not limited. It is preferable to use a thin film or sheet, such as paper, coated with at least one release agent. Any conventional release agent can be used as the release agent. It is preferable that the release layer is easy to peel from the adhesive layer.

[0135] It is preferable to form at least one tab for the release layer, because this allows a user to easily grasp the tab and peel the release layer from the adhesive layer. The tab can be formed, for example, by slightly bending a tip or edge of the release layer.

[0136] An example of a microneedle sheet used for the present invention is illustrated in FIG.

[0137] Figure 1 shows an example of a multi-layer microneedle sheet 1. The multi-layer microneedle sheet 1 comprises microneedles 1-1, a substrate layer 1-2, a base layer 1-3, an adhesive layer 1-4 and a release layer 1-5. These layers are stacked in the order shown in Figure 1.

[0138] In this example, the substrate layer 1-2 is different from the base layer 1-3. However, if the material of the substrate layer 1-2 is the same as the material of the base layer 1-3, it is possible not to use the base layer 1-3. In this case, the adhesive layer 1-4 can be formed on the substrate layer 1-3.

[0139] In this example, the release layer 1-5 has a tab 1-5-1. A user can grab the tab 1-5-1 to peel the release layer 1-5 from the adhesive layer 1-4. Therefore, when the multilayer microneedle sheet 1 is used, the user can easily peel the release layer 1-5 from the adhesive layer 1-4.

[0140] (preparation) There is no limitation on how to prepare the microneedle sheet used for the present invention. The microneedle sheet used for the present invention can be prepared based on conventional techniques such as molding, 3D printing, and droplet-born air blowing.

[0141] The microneedle sheet used for the present invention can be prepared, for example, by a method including a step of molding a composition containing at least one water-soluble or water-dispersible polymer described above.

[0142] In one embodiment, the microneedle sheet used for the present invention is (a) providing a mold having a cavity corresponding to the negative of a microneedle; (b) filling the cavity with a composition comprising at least one water-soluble or water-dispersible polymer as described above; (c) allowing the composition to dry (and optionally heat) at room temperature for a period of time, such as several hours, to solidify and form a microneedle sheet; (d) Removing the microneedle sheet from the mold; It can be prepared by a method comprising:

[0143] The mold can be made from organic materials such as polyamides and silicones, and / or from inorganic materials such as aluminum and steel.

[0144] At least one evaporative liquid component may be included in the composition to enhance the fluidity of the composition, if necessary. Examples of the evaporative liquid component are not limited, but may be preferably water and alcohol such as ethanol.

[0145] The amount of the evaporative liquid component may be 10% by mass or more, preferably 20% by mass or more, more preferably 30% by mass or more, based on the total mass of the composition. The amount of the evaporative liquid component may be 98% by mass or less, preferably 95% by mass or less, more preferably 90% by mass or less, based on the total mass of the composition. Therefore, the amount of the evaporative liquid component may be 10% by mass to 98% by mass, preferably 20% by mass to 95% by mass, more preferably 30% by mass to 90% by mass, based on the total mass of the composition.

[0146] The amount of water-soluble or water-dispersible polymer in the composition, which is preferably flowable and more preferably in liquid form, may be from 2% to 90% by weight, preferably from 5% to 50% by weight, more preferably from 5% to 30% by weight, based on the total weight of the composition.

[0147] If desired, the composition may comprise at least one additional polymer, such as a swellable polymer as described above, and / or at least one polyol and / or at least one cosmetically active ingredient as described above.

[0148] The microneedles and the base layer can be prepared simultaneously by the above-mentioned molding method. In this case, the mold also has a cavity for the base layer, and the cavity for the microneedles in the mold is preferably connected to the cavity for the base layer. Therefore, the base layer and the microneedles can be prepared as a single element.

[0149] When the microneedles and the base layer of the microneedle sheet are different or separate elements, the microneedles may be prepared by the molding methods described above and fixed onto the base layer which is applied separately.

[0150] The shape of the microneedle sheet used for the present invention is not limited, and it may be any shape, such as a lip shape or a shape suitable for application on the face or head, depending on the application target of the microneedle sheet.

[0151] {device} The kit according to the invention comprises at least one device, which is a cosmetic device, preferably a cosmetic device for keratinous materials, more preferably a cosmetic device for the skin, in particular the skin of the face, and also the lips or the scalp.

[0152] The device comprises at least one applicator with at least one application surface, at least one reservoir containing at least one cosmetic composition, and at least one valve.

[0153] The applicator, the container and the valve are configured to deliver the cosmetic composition to an application surface of the applicator through the valve. The microneedle sheet can be attached to the applicator by attaching the substrate layer of the microneedle sheet to the application surface of the applicator. Thus, the applicator, the container and the valve are configured to deliver the cosmetic composition onto the microneedle sheet attached to the applicator.

[0154] The valve can control the delivery of the cosmetic composition onto a microneedle sheet attached to the applicator.

[0155] Thus, the device can apply a microneedle sheet onto the keratinous material such that the microneedles contact the keratinous material, and can also deliver a cosmetic composition onto the keratinous material via the surface of the microneedle sheet.

[0156] (Applicator) The applicator in the device of the kit according to the present invention is for applying the microneedle sheet onto keratinous materials such as the skin, lips and scalp.

[0157] The applicator comprises at least one application surface that can be applied to the skin, in particular the skin of the face, and keratinous materials such as the lips or scalp. The application surface of the applicator can be in contact with the keratinous materials.

[0158] The substrate layer of the microneedle sheet can be attached to the application surface of the applicator. Thus, the microneedle sheet can be attached to the application surface.

[0159] The microneedles of the sheet of microneedles attached to the applicator can contact the skin and keratinous materials such as the lips and scalp, so that the microneedles can penetrate into the keratinous materials.

[0160] The means for attaching the base layer of the microneedle sheet to the application surface of the applicator is not limited. For example, the application surface of the applicator may have an eccentricity, and the base layer of the microneedle may be inserted into that eccentricity.

[0161] It is preferred that the substrate layer of the microneedle sheet is attachable to the application surface of the applicator with an adhesive, more preferably with an adhesive that can be peeled or removed from the application surface, and even more preferably with a pressure sensitive adhesive.

[0162] When the microneedle sheet comprises at least one base layer on a substrate layer as described above, the base layer may be attached to the application surface of an applicator.

[0163] It is preferred that the microneedle sheet comprises at least one adhesive layer as described above on the substrate layer or on the base layer, and that the adhesive layer of the microneedle sheet is attached to the application surface of the applicator.

[0164] For example, with respect to the example microneedle sheet shown in FIG. 1, when the microneedle sheet 1 is to be used, the release layer 1-5 is peeled off from the surface of the adhesive layer 1-4, and the adhesive layer 1-4 is attached to the application surface of an applicator.

[0165] The application surface may be flat or curved (non-flat).

[0166] The type of applicator is not limited as long as the applicator has at least one application surface.

[0167] When the application surface is curved, for example, an applicator comprising at least one cylindrical roller having a curved side, the curved side of the cylindrical roller comprising the application surface, can be used as the applicator.

[0168] (container) The container in the device of the kit according to the present invention is for storing a cosmetic composition.

[0169] The shape of the container is not limited, and may be any shape as long as it can store the cosmetic composition. For example, the container may be in the form of a cylinder or a tube. It is preferable that the container is in a shape such as a cylinder that is easy to handle with one hand.

[0170] The material of the container is not limited and may be flexible or rigid. Non-limiting examples of the container material include plastic, metal, composites of different materials, etc.

[0171] The volume of the container is not limited and can depend on the intended use of the kit according to the present invention.For example, for single use (the cosmetic composition in the container should be used once), the volume of the container can be 10ml or less.On the other hand, for multiple use (the cosmetic composition in the container can be used several times), the volume of the container can be 50ml or more.

[0172] The container can have at least one opening through which the cosmetic composition in the container is released from the container.

[0173] The container may have a pump system that can facilitate the release of the cosmetic composition in the container from the opening.The pump system may be, for example, a plunger in the container that can be operated by hand and can push the cosmetic composition in the container toward the opening.On the other hand, if the material of the container body is soft, a pump system may not be necessary, because the user can squeeze the container to release the cosmetic composition from the opening of the container.

[0174] (valve) The valve in the device of the kit according to the present invention is for controlling the supply of the cosmetic composition from the container to the microneedle sheet attached to the application surface of the applicator.

[0175] Valve, as used herein, refers to an element that can regulate or control the flow of a fluid, such as a cosmetic composition, in a container by opening, closing or partially obstructing the flow path.

[0176] The type of valve is not limited as long as it is capable of controlling the supply of the cosmetic composition from the container to the application surface of the applicator, or from the container onto a microneedle sheet attached to the application surface of the applicator.

[0177] "Controlling" includes stopping or starting the delivery of the cosmetic composition, and can also include regulating the amount of the cosmetic composition delivered.

[0178] Any valve can be used as the valve in the device of the kit according to the present invention. The valve can be selected from conventional valves, such as gate valves, ball valves, butterfly valves and diaphragm valves. It may be preferred that the valve is a gate valve. The gate valve can stop the flow of fluid. Therefore, the gate valve can close the flow of the cosmetic composition from the container to the applicator. It may be more preferred that the valve comprises a rotating disk with at least one eccentric through hole that can connect the opening of the container.

[0179] After the microneedle sheet is attached to the application surface of the applicator, the valve can deliver the cosmetic composition onto the microneedle sheet.

[0180] (Embodiment) Figure 2 shows one embodiment of a device of a kit according to the present invention. The device is capable of delivering a cosmetic composition in its "ON" position, but it is unable to deliver a cosmetic composition in its "OFF" position. Figure 3 shows a schematic diagram of the device in its "ON" and "OFF" positions.

[0181] The device 2 shown in Figure 2 comprises a container 2-1, a valve 2-2, and an applicator 2-3 in the form of a cylindrical roller.

[0182] Container 2-1, shown in Figure 2, is in the form of a hollow cylinder and contains a cosmetic composition therein. Container 2-1 has an opening 2-1-1, shown in Figure 3. Through opening 2-1-1, the cosmetic composition in container 2-1 can be released from container 2-1. Opening 2-1-1 is formed at an eccentric position on the top surface of container 2-1.

[0183] The valve 2-2 shown in Fig. 2 includes a rotating disk 2-2-2 having an eccentric through hole 2-2-1 shown in Fig. 3. The eccentric through hole 2-2-1 can face the applicator 2-3. The valve 2-2 can configure an on-off mechanism with the container 2-1.

[0184] As shown in FIG. 3(a), in the "off" position, the eccentric through hole 2-2-1 of the valve 2-2 is not connected to the opening 2-1-1 of the container 2-1, and the opening 2-1-1 is closed by the rotating disc 2-2-2, so that the cosmetic composition in the container 2-1 cannot be released from the opening 2-1-1 and the eccentric through hole 2-2-1.

[0185] On the other hand, when the user turns the rotating disk 2-2-2 to the "on" position as shown in FIG. 3(b), the eccentric through hole 2-2-1 can be connected to the opening 2-1-1, and thus the cosmetic composition in the container 2-1 can be released from the opening 2-1-1 and the eccentric through hole 2-2-1.

[0186] The applicator 2-3 shown in Figure 2 has a curved side 2-3-1, which has an application surface to which a base layer of a microneedle sheet can be attached. The application surface can face the eccentric through hole 2-2-1 of the valve 2-2.

[0187] In the "off" position shown in Figure 3(a), the cosmetic composition in the container 2-1 cannot be dispensed onto the curved side 2-3-1 of the applicator 2-3, i.e., the application surface of the applicator 2-3. Thus, the cosmetic composition cannot be dispensed onto the microneedle sheet even when the microneedle sheet is attached to the applicator 2-3.

[0188] On the other hand, in the "on" position shown in Figure 3(b), the cosmetic composition in the container 2-1 can be supplied to the application surface of the curved side 2-3-1 of the applicator 2-3, i.e., the application surface of the applicator 2-3. Thus, the cosmetic composition can be supplied onto the microneedle sheet when the microneedle sheet is attached to the applicator 2-3.

[0189] 2 and 3, the container 2-1 is in the form of a cylinder, and a user can use the container 2-1 as a handle for the device 2. As such, a user of the device 2 can use the device 2 by grasping the container 2-1.

[0190] When the microneedle sheet is to be used, it is attached to the applicator 2-3 by attaching the substrate layer of the microneedle sheet to the application surface on the curved side 2-3-1 of the applicator 2-3, which is in the form of a cylindrical roller.

[0191] 4 shows a device 2 having a microneedle sheet 1 attached to an applicator 2-3. The microneedle sheet 1 is attached to an application surface on the curved side of the applicator 2-3 such that the backing layer of the microneedle sheet 1 contacts the application surface. Thus, the microneedles of the microneedle sheet 1 can stand on the curved side of the applicator 2-3.

[0192] At least a portion of the curved side surface of the applicator 2-3 is covered by the microneedle sheet 1. It is preferable that the entire curved side surface of the applicator 2-3 is covered by the microneedle sheet 1.

[0193] FIG. 5 shows how a device 2 having a microneedle sheet 1 can be used.

[0194] When the microneedle sheet 1 is used, the microneedle sheet is attached to an applicator 2-3 by attaching the base layer of the microneedle sheet 1 to the application surface on the curved side of the applicator 2-3 as shown in Fig. 4, and the device 2 having the microneedle sheet 1 is applied onto a keratinous substance 3 such as the skin, lips, and scalp so that the applicator 2-3 can rotate on the keratinous substance 3 as shown in Fig. 5. The microneedles of the microneedle sheet 1 in the device 2 come into contact with the keratinous substance 3 and penetrate into the keratinous substance 3, thereby providing the keratinous substance with a microneedle-derived cosmetic effect.

[0195] Furthermore, when the valve 2-2 is turned to its "on" position, the cosmetic composition in the container 2-1 is dispensed onto the microneedle sheet 1 on the application surface of the applicator 2-3. Thus, the microneedle sheet 1 can also provide the keratinous material 3 with cosmetic benefits from the cosmetic composition as well as cosmetic benefits from the microneedles. The cosmetic composition can penetrate into the keratinous material 3 to a depth resulting from the action of the microneedles.

[0196] When valve 2-2 is turned to its "off" position, the supply of cosmetic composition to the microneedle sheet can be stopped.

[0197] {Storage section} A kit according to the present invention may comprise at least one container.

[0198] The storage section may comprise a microneedle sheet to protect the microneedle sheet, in particular the microneedles of the microneedle sheet, thus allowing safe storage of the microneedle sheet without damaging the microneedles.

[0199] Preferably, the container comprises at least one soft and / or porous article: the microneedles of the microneedle sheet can be safely inserted into a soft article or can be placed in the pores of a porous article when not in use.

[0200] The soft and / or porous article can reduce or eliminate damage to the microneedles, and therefore the use of a soft and / or porous article can provide a safer protection for the microneedles.

[0201] The flexible article may be made of at least one flexible synthetic resin, which may be selected from polyurethane, polystyrene, polycarbonate, polyethylene terephthalate, poly(ethylene-co-vinyl alcohol), polyethylene, polyester, polyamide, and combinations thereof, which may include at least one softening agent.

[0202] The porous article may be made of fibers. The fibers can be made of natural fibers such as cotton, semi-natural fibers such as viscose, synthetic fibers such as polyester and polypropylene fibers, and combinations thereof. The porous article can be selected from woven or nonwoven fabrics.

[0203] The soft porous article may consist of a sponge, which may consist of a foamed synthetic resin, such as a foamed flexible polyurethane.

[0204] It is preferred that the flexible and / or porous article is in the form of a sheet. The flexible and / or porous sheet should have a thickness greater than the height of the microneedles. For example, if the microneedles have a height of 100-400 microns, the thickness of the flexible or porous sheet should be 200-500 microns.

[0205] Fig. 6 shows an example of a storage section. In Fig. 6, the storage section 4 is in the form of a tray having an opening. The material of the storage section 4 is not limited. For example, at least one selected from metal and synthetic resin can be used as the material of the storage section 4.

[0206] 6, the storage section 4 includes a porous sheet 5. The porous sheet 5 is made of a sponge or a woven or nonwoven fabric.

[0207] 6, when the microneedle sheet 1 is not in use, the microneedle sheet 1 is stored in a storage section 4, and the microneedles of the microneedle sheet 1 may penetrate into a protected porous sheet 5. Therefore, the microneedle sheet 1 can be stored with the microneedles protected.

[0208] It may be preferable for the microneedle sheet in the storage section to be packaged by covering the opening of storage section 4, or both the opening of storage section 4 and storage section 4 itself, with a thin film, for example a thin transparent resin film.

[0209] {Cosmetic Composition} Contained in a kit according to the present invention is at least one cosmetic composition.

[0210] The cosmetic composition may be used as a pre-treatment or post-treatment composition for keratin materials.

[0211] It is preferred that the cosmetic composition comprises water, and therefore the cosmetic composition may be, for example, in the form of an aqueous solution.

[0212] On the other hand, the cosmetic composition may comprise at least one oil and water, preferably in the form of an O / W emulsion.

[0213] (oil) The cosmetic composition may comprise at least one oil. If two or more oils are used, they may be the same or different.

[0214] Here, "oil" means a fatty compound or substance that is in liquid or pasty (non-solid) form at atmospheric pressure (760 mmHg) and room temperature (25°C). As oil, any oil commonly used in cosmetics can be used, either alone or in combination. The oil may be volatile or non-volatile.

[0215] The oil may be a hydrocarbon oil, a non-polar oil such as a silicone oil, a vegetable oil or an animal oil, and a polar oil such as an ester oil or an ether oil, or a mixture thereof.

[0216] The oil may be selected from the group consisting of oils of vegetable or animal origin, synthetic oils, silicone oils, hydrocarbon oils and fatty alcohols.

[0217] Examples of vegetable oils include, for example, linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, soybean oil, peanut oil, and mixtures thereof.

[0218] Examples of animal oils include, for example, squalene and squalane.

[0219] Examples of synthetic oils include alkane oils such as isododecane and isohexadecane, ester oils, ether oils, and artificial triglycerides.

[0220] The ester oil is preferably a saturated or unsaturated, linear or branched C1-C 26 Aliphatic mono- or polyacids and saturated or unsaturated, linear or branched C1-C 26 It is a liquid ester of an aliphatic monoalcohol or polyalcohol, and the total number of carbon atoms in the ester is 10 or more.

[0221] Preferably, in the case of esters of monohydric alcohols, at least one of the alcohols and acids from which the esters of the invention are derived is branched.

[0222] Among the monoesters of monoacids and monohydric alcohols, mention may be made of ethyl palmitate, ethylhexyl palmitate, isopropyl palmitate, dicaprylyl carbonate, alkyl myristates such as isopropyl myristate or ethyl myristate, isocetyl stearate, 2-ethylhexyl isononanoate, isononyl isononanoate, isodecyl neopentanoate and isostearyl neopentanoate.

[0223] C4~C 22 Dicarboxylic or tricarboxylic acids and C1-C 22 Esters with alcohols, and mono-, di- or tricarboxylic acids and non-sugar C4-C 26 Esters with dihydroxy, trihydroxy, tetrahydroxy or pentahydroxy alcohols can also be used.

[0224] Mention may in particular be made of diethyl sebacate, isopropyl lauroyl sarcosinate, diisopropyl sebacate, bis(2-ethylhexyl) sebacate, diisopropyl adipate, di-n-propyl adipate, dioctyl adipate, bis(2-ethylhexyl) adipate, diisostearyl adipate, bis(2-ethylhexyl) maleate, triisopropyl citrate, triisocetyl citrate, triisostearyl citrate, glyceryl trilactate, glyceryl trioctanoate, trioctyldodecyl citrate, trioleyl citrate, neopentyl glycol diheptanoate, diethylene glycol diisononanoate.

[0225] As ester oil, C6-C 30 , preferably C 12 ~C 22Sugar esters and diesters of fatty acids can be used. It is recalled that the term "sugar" means an oxygen-bearing hydrocarbon-based compound containing several alcohol functional groups, with or without aldehyde or ketone functional groups, and containing at least 4 carbon atoms. These sugars can be monosaccharides, oligosaccharides or polysaccharides.

[0226] Examples of suitable sugars that may be mentioned are sucrose (or saccharose), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose and lactose, as well as derivatives thereof, in particular alkyl derivatives, such as methyl derivatives, e.g. methylglucose.

[0227] Sugar esters of fatty acids are made by combining the aforementioned sugars with linear or branched, saturated or unsaturated C6-C 30 , preferably C 12 ~C 22 These compounds, when unsaturated, can have from 1 to 3 conjugated or non-conjugated carbon-carbon double bonds.

[0228] The esters according to this variant may also be chosen from monoesters, diesters, triesters, tetraesters and polyesters, and mixtures thereof.

[0229] These esters may be, for example, oleate, laurate, palmitate, myristate, behenate, coconut, stearate, linoleate, linolenate, caprate and arachidonic acid esters, or mixtures thereof, such as, in particular, the mixed esters of oleopalmitate, oleostearate and palmitostearate, and pentaerythrityl tetraethylhexanoate.

[0230] More particularly, mono- and diesters are used, in particular the mono- or dioleate, stearate, behenate, oleopalmitate, linoleate, linolenate and oleostearate of sucrose, glucose or methylglucose.

[0231] An example that may be mentioned is the product sold under the name Glucate® DO by the company Amerchol, which is a methylglucose dioleate.

[0232] Examples of preferred ester oils include diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanoate, octyldodecyl octanoate, isodecyl neopentanoate, myristyl propionate, 2-ethylhexyl 2-ethylhexanoate, 2-ethylhexyl octanoate, 2-ethylhexyl (caprylic acid / capric acid), methyl palmitate, ethyl palmitate, isopropyl palmitate, dicarbonate, and the like. Included are prilyl, isopropyl lauroyl sarcosinate, isononyl isononanoate, ethylhexyl palmitate, isohexyl laurate, hexyl laurate, isocetyl stearate, isopropyl isostearate, isopropyl myristate, isodecyl oleate, glyceryl tri(2-ethylhexanoate), pentaerythrityl tetra(2-ethylhexanoate), 2-ethylhexyl succinate, diethyl sebacate, and mixtures thereof.

[0233] Examples of artificial triglycerides include capryl caprylyl glyceride, glyceryl trimyristate, glyceryl tripalmitate, glyceryl trilinolenate, glyceryl trilaurate, glyceryl tricaprate, glyceryl tricaprylate, capric / caprylic triglyceride, and capric / caprylic / linolenic triglyceride.

[0234] Examples of silicone oils include linear organopolysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, and the like; cyclic organopolysiloxanes such as cyclohexasiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, and the like; and mixtures thereof.

[0235] Preferably, the silicone oil is chosen from liquid polydialkylsiloxanes, in particular liquid polydimethylsiloxanes (PDMS), and liquid polyorganosiloxanes containing at least one aryl group.

[0236] These silicone oils may also be organically modified. The organically modified silicones that may be used according to the invention are silicone oils as defined above, which contain in their structure one or more organic functional groups linked via a hydrocarbon-based group.

[0237] Organopolysiloxanes are defined in great detail in Walter Noll, Chemistry and Technology of Silicones, Academic Press, 1968. They may be volatile or nonvolatile.

[0238] If they are volatile, the silicones are more particularly chosen from those having a boiling point between 60° C. and 260° C., and even more particularly chosen from: (i) Cyclic polydialkylsiloxanes containing 3 to 7, preferably 4 to 5, silicon atoms. These are, for example, octamethylcyclotetrasiloxane, sold in particular under the name Volatile Silicone® 7207 by Union Carbide or under the name Silbione® 70045 V2 by Rhodia, decamethylcyclopentasiloxane, sold in particular under the name Volatile Silicone® 7158 by Union Carbide and under the name Silbione® 70045 V5 by Rhodia, and dodecamethylcyclopentasiloxane, sold under the name Silsoft 1217 by Momentive Performance Materials, and mixtures thereof. Formula:

[0239] [ka]

[0240] Mention may also be made of cyclocopolymers of the dimethylsiloxane / methylalkylsiloxane type, such as Silicone Volatile® FZ 3109 sold by Union Carbide, Inc. Mention may also be made of mixtures of cyclic polydialkylsiloxanes with organosilicon compounds, such as a mixture (50 / 50) of octamethylcyclotetrasiloxane and tetratrimethylsilylpentaerythritol, and a mixture of octamethylcyclotetrasiloxane and oxy-1,1'-bis(2,2,2',2',3,3'-hexatrimethylsilyloxy)neopentane, (ii) Contains 2 to 9 silicon atoms and has a molecular weight of 5 × 10 at 25 °C -6 m 2A linear volatile polydialkylsiloxane having a viscosity of less than 10000 / s. An example is decamethyltetrasiloxane, sold in particular under the name SH 200 by Toray Silicone. Silicones belonging to this class are also described in the article published by Todd & Byers "Volatile Silicone Fluids for Cosmetics", Cosmetics and Toiletries, Vol. 91, January 1976, pp. 27-32. The viscosity of the silicones is measured at 25°C according to ASTM Standard 445 Appendix C.

[0241] Non-volatile polydialkylsiloxanes can also be used, these being more particularly chosen from the polydialkylsiloxanes, among which mention may be made mainly of polydimethylsiloxanes having trimethylsilyl end groups.

[0242] Among these polydialkylsiloxanes, mention may be made, but is not limited to, the following commercial products: the Silbione® oils of the 47 and 70 047 series or Mirasil® oils sold by the company Rhodia, such as for example the 70 047 V 500 000 oil; the Mirasil® series of oils sold by the company Rhodia; - Dow Corning 200 series oils, e.g. DC200 with a viscosity of 60000mm2 / s, as well as - Viscasil® oils manufactured by General Electric and certain oils of the SF series manufactured by General Electric (SF 96, SF 18).

[0243] Mention may also be made of polydimethylsiloxanes having dimethylsilanol end groups, known under the name dimethiconol (CTFA), such as the 48 series oils from Rhodia.

[0244] Among the silicones containing aryl groups, mention may be made of the polydiarylsiloxanes, especially polydiphenylsiloxanes, and polyalkylarylsiloxanes, such as phenylsilicone oils.

[0245] Phenyl silicone oils have the following formula:

[0246] [ka]

[0247] (In the formula, R1~R 10 are each independently a saturated or unsaturated, linear, cyclic or branched C1-C 30 Hydrocarbon group, preferably C1-C 12 a hydrocarbon group, more preferably a C1 to C6 hydrocarbon group, in particular a methyl, ethyl, propyl or butyl group; m, n, p and q each independently represent an integer of 0 to 900, inclusive, preferably 0 to 500, inclusive, and more preferably 0 to 100, inclusive; However, the sum n+m+q is not 0. The phenyl silicone may be selected from the group consisting of phenyl silicones.

[0248] Examples that may be mentioned are products sold under the following names: - Rhodia Silbione® oils, series 70 641; Rhodorsil® 70 633 and 763 series oils from Rhodia, - Dow Corning 556 Cosmetic Grade Fluid oil, - PK series silicones from Bayer, e.g. product PK20, - certain oils of the SF series manufactured by General Electric, such as SF 1023, SF 1154, SF 1250 and SF 1265.

[0249] As the phenyl silicone oil, phenyl trimethicone (R1 to R2 in the above formula) 10 is methyl, p, q and n=0, m=1).

[0250] The organically modified liquid silicones may in particular have polyethyleneoxy and / or polypropyleneoxy groups. Mention may therefore be made of silicone KF-6017 proposed by Shin-Etsu Chemical Co., Ltd., and Silwet® L722 and L77 oils from Union Carbide.

[0251] The hydrocarbon oil may be chosen from: - Linear or branched, optionally cyclic, C6-C 16 Lower alkanes. Examples that may be mentioned include hexane, undecane, dodecane, tridecane, and isoparaffins, such as isohexadecane, isododecane, and isodecane; - linear or branched hydrocarbons having more than 16 carbon atoms, such as liquid paraffin, petroleum jelly, polydecenes and hydrogenated polyisobutenes, such as Parleam®, and squalane.

[0252] Preferred examples of hydrocarbon oils include, for example, linear or branched hydrocarbons such as isohexadecane, isododecane, squalane, mineral oils (e.g., liquid paraffin), paraffin, vaseline or petrolatum, naphthalene, and the like; hydrogenated polyisobutene, isoeicosane, and decene / butene copolymers; and mixtures thereof.

[0253] The term "fatty" in fatty alcohols refers to those containing a relatively large number of carbon atoms. Thus, alcohols having 4 or more carbon atoms, preferably 6 or more, more preferably 12 or more carbon atoms are included within the scope of fatty alcohols. Fatty alcohols may be saturated or unsaturated. Fatty alcohols may be linear or branched.

[0254] The fatty alcohol may have the structure R-OH, where R is selected from saturated and unsaturated, linear and branched groups having from 4 to 40 carbon atoms, preferably from 6 to 30 carbon atoms, and more preferably from 12 to 20 carbon atoms. In at least one embodiment, R is selected from C 12 ~C 20 Alkyl group and C 12 ~C 20 alkenyl groups, R may be substituted or unsubstituted with at least one hydroxy group.

[0255] Examples of fatty alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, undecylenyl alcohol, myristyl alcohol, octyldodecanol, hexyldecanol, oleyl alcohol, linoleyl alcohol, palmitoleyl alcohol, arachidonyl alcohol, erucyl alcohol, and mixtures thereof.

[0256] Preferably, the fatty alcohol is a saturated fatty alcohol.

[0257] Therefore, fatty alcohols are linear or branched, saturated or unsaturated, C6-C 30 Alcohols, preferably linear or branched, saturated C6-C 30 Alcohols, more preferably linear or branched, saturated C 12 ~C 20 Alcohol can be selected.

[0258] The term "saturated fatty alcohol" as used herein means an alcohol having a long aliphatic saturated carbon chain. A saturated fatty alcohol is any linear or branched, saturated C-C 30 It is preferably selected from fatty alcohols, linear or branched, saturated C6-C 30 Among fatty alcohols, linear or branched, saturated C 12 ~C 20Fatty alcohols are preferably used. Any linear or branched, saturated C 16 ~C 20 Fatty alcohols are more preferably used. 16 ~C 20 Fatty alcohols may even more preferably be used.

[0259] Examples of saturated fatty alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, undecylenyl alcohol, myristyl alcohol, octyldodecanol, hexyldecanol, and mixtures thereof. In one embodiment, cetyl alcohol, stearyl alcohol, octyldodecanol, hexyldecanol, or mixtures thereof (e.g., cetearyl alcohol) and behenyl alcohol can be used as the saturated fatty alcohol.

[0260] According to at least one embodiment, the fatty alcohol used in the cosmetic composition is preferably chosen from cetyl alcohol, octyldodecanol, hexyldecanol, and mixtures thereof.

[0261] It may be preferred that the oil is selected from ester oils, hydrocarbon oils, silicone oils, fatty alcohols, and mixtures thereof.

[0262] The amount of oil in the cosmetic composition may be 1% by mass or more, preferably 5% by mass or more, more preferably 10% by mass or more, based on the total mass of the cosmetic composition. The amount of oil in the cosmetic composition may be 30% by mass or less, preferably 25% by mass or less, more preferably 20% by mass or less, based on the total mass of the cosmetic composition. The amount of oil in the cosmetic composition may be 1% by mass to 30% by mass, preferably 5% by mass to 25% by mass, more preferably 10% by mass to 20% by mass, based on the total mass of the cosmetic composition.

[0263] The oil may form the fatty phase of the cosmetic composition.

[0264] When the cosmetic composition is in the form of an O / W emulsion, the oil may form a dispersed fatty phase in the O / W emulsion.

[0265] (water) The cosmetic composition may comprise water.

[0266] The amount of water may be 50% by mass or more, preferably 55% by mass or more, more preferably 60% by mass or more, based on the total mass of the cosmetic composition. The amount of water may be 95% by mass or less, preferably 90% by mass or less, more preferably 85% by mass or less, based on the total mass of the cosmetic composition. The amount of water in the cosmetic composition may be in the range of 50% by mass to 95% by mass, preferably 55% by mass to 90% by mass, more preferably 60% by mass to 85% by mass, based on the total mass of the cosmetic composition.

[0267] The water may form the aqueous phase of the cosmetic composition.

[0268] When the cosmetic composition is in the form of an O / W emulsion, water may form the continuous aqueous phase in the O / W emulsion.

[0269] (Other ingredients) The cosmetic composition may include at least one structuring or gelling agent. Examples of structuring or gelling agents include, but are not limited to, cellulose derivatives (methylcellulose, methylethylcellulose), plant-derived hydrocolloids (alginates, carrageenans, pectins, etc.), starch derivatives, and gums such as xanthan gum.

[0270] The cosmetic composition may include a humectant, such as a polyol, as described above.

[0271] The cosmetic composition may include at least one cosmetic active ingredient as described above.

[0272] The cosmetic composition may also include various adjuvants conventionally used in cosmetic compositions, such as anionic, nonionic, cationic, and amphoteric or zwitterionic surfactants, anionic, nonionic, cationic, and amphoteric or zwitterionic polymers, pH adjusters, skin tone modifying agents, anti-acne agents, and combinations thereof.

[0273] (form) It is preferred that the cosmetic composition contains a substantial amount of water, because this facilitates dissolution of the microneedles. It may therefore be preferred that the cosmetic composition is in the form of an aqueous solution or an O / W emulsion.

[0274] In one embodiment, the cosmetic composition may be in the form of an aqueous gel (or hydrogel), which may contain about 50% to about 99.9% by weight (preferably about 60% to 95% by weight, more preferably about 70% to about 90% by weight) of water, and preferably about 50% to about 99.9% by weight (preferably about 5% to about 40% by weight, more preferably about 10% to about 30% by weight) of other cosmetic ingredients.

[0275] (preparation) The cosmetic composition that can be used for the present invention can be prepared, for example, by mixing the oil, water, and, if necessary, other ingredients, as explained above.

[0276] The method and means for mixing the above components are not limited. Any conventional method and means can be used to mix the above components to prepare the cosmetic composition that can be used for the present invention.

[0277] [Beauty method] The cosmetic method for treating keratinous substances such as the skin, lips and scalp according to the present invention comprises the steps of: Attaching at least one microneedle sheet to at least one applicator having at least one application surface by attaching a substrate layer of the microneedle sheet to the application surface of the applicator, The microneedle sheet comprises a base layer and a plurality of microneedles on the base layer, the microneedles including at least one water-soluble or water-dispersible polymer; The applicator is provided in at least one device having at least one container containing at least one cosmetic composition and at least one valve; The process and applying an applicator onto the keratinous material such that the microneedles contact the keratinous material; The applicator, the container, and the valve are configured to deliver a cosmetic composition through the valve onto a microneedle sheet attached to the applicator; a valve capable of controlling delivery of the cosmetic composition onto a microneedle sheet attached to the applicator; A cosmetic composition is provided on the microneedle sheet during the step of applying the applicator onto the keratinous material; Process and Includes.

[0278] The cosmetic method according to the present invention can be carried out using the kit according to the present invention.

[0279] The cosmetic method according to the invention can be intended for the cosmetic treatment of keratinous materials such as the skin, lips and scalp, preferably the skin, more preferably the skin of the face.

[0280] Prior to attachment of the microneedle sheet to the applicator, the applicator, the reservoir and the valve are configured to deliver a cosmetic composition through the valve to an application surface of the applicator.

[0281] When carrying out the cosmetic method according to the present invention, the microneedle sheet is attached to the applicator by attaching the base layer of the microneedle sheet to the application surface of the applicator and fixing the microneedle sheet to the applicator.

[0282] It is preferred that the microneedle sheet is stored in a storage unit as described above and is removed from the storage unit when the microneedle sheet is to be used.

[0283] It may be preferred that the microneedle sheet comprises at least one base layer on a substrate layer, the base layer being attached to the application surface of the applicator.

[0284] It may be preferred that the microneedle sheet comprises at least one adhesive layer on the substrate layer and the base layer, the adhesive layer being attached to the application surface of the applicator.

[0285] It is further preferred that the microneedle sheet comprises at least one release layer on the adhesive layer, and that the release layer is detached from the surface of the adhesive layer during use of the microneedle sheet.

[0286] After the microneedle sheet is attached to the applicator, the container and the valve are configured to dispense the cosmetic composition through the valve onto the microneedle sheet attached to the applicator. The valve is capable of controlling the dispensing of the cosmetic composition onto the microneedle sheet attached to the applicator.

[0287] The applicator is then applied onto the keratinous material such that the microneedles are in contact with the keratinous material, in other words the microneedle sheet is applied onto the keratinous material.

[0288] The application may be performed by a user by manipulating the device with an applicator.

[0289] When the applicator is in the form of a roller, the applicator with the microneedle sheet can be applied onto the keratinous material by rotating the applicator on the keratinous material. For example, the applicator can be rotated back and forth on the keratinous material. The number of cycles of back and forth motion will depend on various factors, such as the sensitivity of the keratinous material and the cosmetic composition used in combination with the microneedle sheet. In one embodiment, the back and forth motion can be 4 or 5 cycles, which can take about 1 minute when the keratinous material is facial skin.

[0290] Therefore, the microneedles of the microneedle sheet can penetrate into keratinous materials to provide cosmetic effects.

[0291] The cosmetic method according to the invention can be used to improve the aesthetic appearance of keratinous materials, for example by reducing the appearance of wrinkles or by delivering any cosmetic active ingredient to the keratinous materials when present in the microneedles.

[0292] A decrease in the amount of matrix, such as the epidermis, in the skin tends to lead to a decrease in skin thickness and a deterioration in skin elasticity, which causes the formation of wrinkles. Microneedles can increase the amount of matrix in the skin, thus causing an increase in skin elasticity, which leads to a reduction in wrinkles on the skin.

[0293] If the microneedle is swellable, especially at its distal end, it can swell in the skin, further increasing the volume of the microneedle, for example with its absorption of water in the skin. Such volume expansion under the skin surface at the wrinkle site can effectively push the wrinkle from inside the skin, making the wrinkle shallower and wider. In this way, the wrinkle can be reduced or made less noticeable.

[0294] Therefore, it is preferable that the cosmetic method according to the present invention includes a step of pressing a microneedle sheet onto a keratinous substance to ensure that the microneedles of the microneedle sheet are inserted into the keratinous substance such as the skin, lips, and scalp.

[0295] In certain embodiments, the cosmetic method according to the present invention can be used to apply semi-permanent or permanent cosmetic treatments to keratinous materials such as skin.

[0296] According to the cosmetic method of the present invention, the cosmetic composition can be used in combination with a microneedle sheet.

[0297] Thus, the cosmetic composition can be provided on the microneedle sheet during the step of applying the applicator onto the keratinous material. The cosmetic composition can be present on the microneedle sheet, in particular between the microneedles of the microneedle sheet. The cosmetic composition can be transferred from the microneedle sheet to the surface of the keratinous material, such as the skin, lips, and scalp. Thus, the cosmetic composition can be applied from the microneedle sheet onto the keratinous material.

[0298] Since the cosmetic composition can be applied onto the keratinous material in combination with the microneedle sheet, the cosmetic composition can penetrate into the keratinous material relatively easily through the holes / holes formed thereon by the microneedles of the microneedle sheet, compared to when the microneedle sheet is not used. Thus, the cosmetic composition can penetrate much deeper into the keratinous material, and a relatively large amount of the cosmetic composition can be delivered into the keratinous material, compared to when the microneedle sheet is not used.

[0299] Furthermore, the microneedles may be dissolved or dispersed within the keratin material and / or within the cosmetic composition, which may preferably include water, thus making repeated use of the microneedles impossible.

[0300] Furthermore, the cosmetic method according to the present invention allows for easy and hygienic application of the cosmetic composition to keratinous materials.

[0301] It is preferable that the cosmetic method according to the present invention further comprises a step of applying the applicator onto keratinous material without supplying a cosmetic composition onto the microneedle sheet on the application surface of the applicator.

[0302] When the applicator is in the form of a roller, the applicator with the microneedle sheet can be applied onto the keratinous material by rotating the applicator on the keratinous material. For example, the applicator can be rotated back and forth on the keratinous material. The number of cycles of back and forth motion will depend on various factors, such as the sensitivity of the keratinous material and the cosmetic composition used in combination with the microneedle sheet. In one embodiment, the back and forth motion can be 4 or 5 cycles, which can take about 1 minute when the keratinous material is facial skin.

[0303] The above actions may be performed by a user by manipulating the device with an applicator.

[0304] As such, the microneedles of the microneedle sheet penetrate into the keratin material to provide a cosmetic effect.

[0305] It is preferable that the above-mentioned additional step of applying the applicator onto the keratinous material without supplying a cosmetic composition onto the microneedle sheet on the application surface of the applicator is performed before the step of applying the applicator onto the keratinous material with supplying a cosmetic composition onto the microneedle sheet on the application surface of the applicator, because the surface structure of the keratinous material is altered (e.g., more pores / holes may be formed) and can receive more cosmetic composition. EXAMPLES

[0306] The present invention will be described in more detail by examples. However, these examples should not be construed as limiting the scope of the present invention. The following examples are presented as non-limiting examples in the field of the present invention.

[0307] [Microneedle patch] A microneedle sheet was prepared from hyaluronic acid and trehalose. The microneedle sheet had a plurality of microneedles on a substrate layer. Each microneedle had a cone shape with a length or height of 250 μm. The microneedle sheet was cut so that it had the shape of a patch with a size of 8 cm×2 cm.

[0308] [device] A device was prepared, which had an applicator having an application surface, a container containing an aqueous solution of 1% by weight hyaluronic acid (MW: 20-50 kDa) labeled with a fluorescent dye, and a rotating valve, in which the applicator, container, and valve shown in FIG. 3 were set to supply the solution to the application surface of the applicator through the valve, and the valve could control the supply of the solution to the application surface of the applicator. The applicator was in the form of a cylindrical roller. Therefore, the side surface of the cylindrical roller was used as the application surface. The size of the application surface was 8 cm x 2 cm.

[0309] [Microneedle Assembly] The microneedle assembly was prepared by mounting the microneedle patch on the application surface of an applicator in the form of a cylindrical roller. The applicator, reservoir and rotating valve were set to deliver the fluorescent hyaluronic acid aqueous solution onto the microneedle patch such that the valve could control the delivery of the solution onto the microneedle patch.

[0310] [evaluation] (Resurfacing effect) Human cadaver skin from the same donor was cut into sections, each section having a size of 8 cm x 2 cm. They were divided into two groups: a treatment group and a control group.

[0311] For the treatment group, the skin is treated with the microneedle assembly by moving the applicator in the form of a cylindrical roller back and forth in one direction on the skin, so that the microneedle sheet contacts the skin 10 times.The valve is in its "off" position.Therefore, the fluorescent hyaluronic acid aqueous solution is not applied onto the microneedle patch.

[0312] For the control group, the skin was not treated with the microneedle assembly.

[0313] Samples were then prepared by cutting an area of ​​0.5 cm x 0.5 cm from each of the skin sections, and the surface of each sample was observed under a microscope (SEM).

[0314] By comparing the samples, it was found that the skin in the treatment group showed more array patterns on the skin morphology due to the passage of the microneedles on the skin than the skin in the control group, indicating a successful and efficient resurfacing effect of the treatment according to the present invention.

[0315] (Penetration enhancing effect) Human cadaver skin from the same donor was cut into sections, each section having a size of 8 cm x 2 cm. They were divided into two groups: a treatment group and a control group.

[0316] For the treatment group, the skin is treated with the microneedle assembly by moving the applicator in the form of a cylindrical roller back and forth in one direction on the skin, so that the microneedle sheet contacts the skin 10 times.The valve is in its "off" position.Therefore, the fluorescent hyaluronic acid aqueous solution is not applied onto the microneedle patch.

[0317] The same process was then repeated except that the valve was turned to its "on" position so that the aqueous fluorescent hyaluronic acid solution was dispensed onto the microneedle patch.

[0318] For the control group, the skin was treated by simple application of the fluorescent hyaluronic acid aqueous solution onto the skin without applying a microneedle assembly onto the skin.

[0319] After 15 minutes, a 0.5 cm x 1 cm area was cut from each of the skin sections to prepare blocks. The blocks were treated with OCT compound and frozen in liquid nitrogen. The blocks were sliced ​​into samples with a thickness of 15 μm using a Cryostat. The cross section of each sample was observed under a microscope (confocal laser fluorescence microscope).

[0320] By comparing the samples, it was found that in the treatment group, the fluorescent hyaluronic acid penetrated much deeper into the skin than in the control group, whereas in the control group, the fluorescent hyaluronic acid penetrated only into the very surface of the skin, indicating that the treatment according to the present invention could enhance the penetration of hyaluronic acid into the skin.

[0321] (Changes in microneedle shape) In the above treatment to evaluate the penetration enhancement effect, the shape of the microneedles was observed under a microscope before and after application of the microneedle patch having the fluorescent hyaluronic acid aqueous solution to the treatment groups.

[0322] The shape of the microneedles became shorter and blunter after co-application of the fluorescent hyaluronic acid aqueous solution, indicating that the fluorescent hyaluronic acid aqueous solution was reliably dispensed from the container onto the microneedle patch to dissolve the microneedles.

[0323] Because the shape of the microneedles changed, it was not possible to reuse the microneedle patch. [Explanation of symbols]

[0324] 1. Multi-layer microneedle sheet 1-1 Microneedle 1-2 Base material layer 1-3 Basal layer 1-4 Adhesive layer 1-5 Peeling layer 1-5-1 Tab 2 Devices 2-1 Container 2-1-1 Opening 2-2 Valve 2-2-1 Eccentric through hole 2-2-2 Rotating disk 2-3 Applicator 2-3-1 Curved side 3. Keratin Substances 4 Storage area 5. Porous Sheet

Claims

1. A base layer (1-2), and A plurality of microneedles (1-1) on the substrate layer (1-2), the microneedles comprising at least one water-soluble or water-dispersible polymer. At least one microneedle sheet (1), at least one applicator (2-3) having at least one application surface; At least one container (2-1) containing at least one cosmetic composition, and At least one valve (2-2) At least one device (2) comprising A kit for the skin, lips or scalp, comprising: The microneedle sheet (1) can be attached to the applicator (2-3) by attaching the base layer (1-2) of the microneedle sheet (1) to the application surface of the applicator (2-3); the applicator (2-3), the container (2-1) and the valve (2-2) are configured to supply the cosmetic composition onto the microneedle sheet (1) via the valve (2-2) during use of the microneedle sheet (1) attached to the applicator (2-3); The valve (2-2) is capable of controlling the supply of the cosmetic composition onto the microneedle sheet (1) attached to the applicator (2-3); The container (2-1) is hollow and cylindrical, and has an opening (2-1-1) at an eccentric position on a top surface of the container (2-1); The valve (2-2) comprises a rotating disk (2-2-2) having an eccentric through hole (2-2-1), A kit for the skin, lips or scalp, characterized in that the eccentric through hole (2-2-1) is connected to the opening (2-1-1) of the container (2-1) so as to be capable of releasing the cosmetic composition from the opening (2-1-1) and the eccentric through hole (2-2-1) during use of the microneedle sheet (1).

2. The kit described in claim 1, wherein the base layer (1-2) of the microneedle sheet (1) is removable from the application surface of the applicator (2-3) after being attached to the application surface of the applicator (2-3).

3. The microneedle sheet (1) comprises at least one base layer (1-3), 3. The kit according to claim 1, wherein the base layer (1-3) is fixed on a substrate layer (1-2).

4. The microneedle sheet (1) comprises at least one adhesive layer (1-4), 3. The kit according to claim 1, wherein the adhesive layer (1-4) is fixed on a base layer (1-2).

5. The microneedle sheet (1) has at least one adhesive layer (1-4), The kit according to claim 3, wherein the adhesive layer (1-4) is fixed on a base layer (1-3).

6. The microneedle sheet (1) has at least one release layer (1-5), 6. The kit according to claim 4 or 5, wherein the release layer (1-5) is disposed on the adhesive layer (1-4).

7. The kit according to any one of claims 1 to 6, wherein the microneedle (1-1) has a height of 50 to 1000 microns.

8. 8. The kit according to any one of claims 1 to 7, wherein the application surface of the applicator (2-3) is curved.

9. The applicator (2-3) comprises at least one cylindrical roller having a curved side, 9. The kit of claim 8, wherein the curved side of the cylindrical roller comprises the application surface.

10. Further comprising at least one storage section (4), The kit according to any one of claims 1 to 9, wherein the storage section (4) is capable of storing the microneedle sheet (1).

11. 11. The kit according to claim 10, wherein the container (4) comprises at least one soft and / or porous article.

12. 12. The kit according to claim 1, wherein the valve (2-2) is a gate valve.

13. The kit according to any one of claims 1 to 12, wherein the cosmetic composition comprises at least one cosmetic active ingredient.

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