Cosmetics

Abstract

Provided is a cosmetic that is excellent in terms of freshness during application and moist feel and lack of tackiness after application, and gives an adequate use feel, despite containing niacinamide, which tends to cause tackiness. This cosmetic is characterized by containing: (A) niacinamide; and (B) a polyacrylic acid having a weight average molecular weight of 500,000 to 8,000,000, wherein the content, in terms of compounds having a molecular weight of 10,000,000 or greater, is 10% by mass or less, or a salt thereof.

Description

[Technical field]

[0001] The present invention relates to a cosmetic preparation which, despite containing nicotinic acid amide which is liable to cause stickiness, is excellent in freshness during application, non-stickiness and moisturization of the skin after application, and has a good feel in use. [Background technology]

[0002] The basic functions of skin care cosmetics include anti-drying, anti-UV, anti-oxidation, and activation. In addition, some skin care cosmetics have functions such as whitening and anti-aging, improving wrinkles and sagging, and preventing rough skin. Among them, vitamin B is known as a substance that has various physiological actions such as improving rough skin, whitening effect, and anti-aging effect. In particular, nicotinamide (vitamin B3) has wrinkle-improving and whitening effects, and in recent years has also been recognized to have a certain effect on improving acne (acne vulgaris), and its application to various cosmetics is being considered.

[0003] As an example of a cosmetic composition containing nicotinamide, Patent Document 1 describes a skin anti-aging cosmetic composition that contains (a) nicotinamide, which is a ceramide synthesis promoter, and (b) urea or an α-hydroxycarboxylic acid compound having 2 to 28 carbon atoms, which is a skin tissue activator. It is said that the combined use of these ingredients can produce anti-aging effects (effects of improving rough skin, improving keratin, and accelerating turnover rate) and skin beautifying effects in a short period of time.

[0004] Patent Document 2 describes a skin cosmetic that contains a fibroblast collagen synthesis promoter and a fibroblast collagenase production promoter that enhance collagen metabolism, as well as an epidermal cell ceramide synthesis promoter such as nicotinamide. It is said that the combined use of these ingredients can comprehensively enhance skin function and provide an anti-aging effect on the skin.

[0005] Thus, nicotinamide has various functions and is widely used in cosmetics as an active ingredient for beauty. However, it is known that when a large amount of nicotinamide is blended in a cosmetic, the freshness during application is lost, the skin becomes sticky after application, and the skin becomes insufficiently moisturized, which may impair the feeling of use (e.g., Patent Document 3). [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Publication No. 10-130135 [Patent Document 2] Japanese Patent Application Publication No. 10-1414 [Patent Document 3] Special Publication No. 2003-502435 DISCLOSURE OF THEINVENTION [Problem to be solved by the invention]

[0007] To provide a cosmetic preparation which contains nicotinic acid amide having a skin improving effect, yet has excellent moisture during application, non-stickiness and moisturizing effect on the skin after application, and has a good feel in use. [Means for solving the problem]

[0008] As a result of intensive research into solving the above-mentioned problems, the inventors discovered that the deterioration of the usability caused by nicotinamide can be improved by combining nicotinamide with polyacrylic acid or a salt thereof whose molecular weight is controlled to satisfy certain conditions, and thus completed the present invention.

[0009] That is, the present invention provides (A) nicotinamide, and (B) polyacrylic acid or a salt thereof having a weight average molecular weight of 500,000 to 8,000,000 and a content of a compound having a molecular weight of 10,000,000 or more of 10 mass% or less; The present invention provides a cosmetic composition comprising: Effect of the Invention

[0010] By having the above-mentioned composition, the cosmetic of the present invention contains an effective amount of nicotinamide for improving skin, yet provides an excellent feeling of moisture when applied to the skin, suppresses stickiness of the skin after application, and further provides sufficient moisture to the skin, thereby achieving an excellent feel when used that has not been seen before. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] The cosmetic of the present invention is characterized by containing (A) nicotinamide and (B) a polyacrylic acid or a salt thereof having a controlled molecular weight. The cosmetic of the present invention will be described in detail below.

[0012] <(A) Nicotinamide> Nicotinamide (A) (hereinafter, sometimes simply referred to as "ingredient (A)") blended in the cosmetic of the present invention is an amide compound of nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin and is a widely known substance as one of the B vitamins. In the present invention, nicotinamide (A) is not particularly limited, and it is possible to use nicotinamide extracted from natural products such as rice bran, or nicotinamide synthesized by a known method.

[0013] The content of the component (A) in the present invention is not particularly limited, but is preferably 0.5 to 10% by mass, more preferably 1 to 10% by mass, and even more preferably 3 to 8% by mass, based on the total amount of the cosmetic. Within this range, a cosmetic can be obtained that is sufficiently effective in improving rough skin, whitening, and preventing skin aging, while also providing a sufficiently excellent feeling in use, such as a fresh feeling during application and no stickiness on the skin after application.

[0014] <(B) Polyacrylic acid or its salt having a controlled molecular weight> The molecular weight-controlled polyacrylic acid or salt thereof (B) blended in the cosmetic of the present invention (hereinafter, may be simply referred to as "component (B)") is a water-soluble polymer whose molecular weight is controlled so that (i) it has a weight-average molecular weight of 500,000 to 8,000,000, and (ii) the content of compounds having a molecular weight of 10,000,000 or more is 10 mass% or less. The (i) weight average molecular weight of the (B) component is 500,000 or more, more preferably 800,000 or more, even more preferably 1 million or more, and is 8 million or less, more preferably 5 million or less, and even more preferably 3 million or less. If the weight average molecular weight is less than 500,000, the cosmetic composition tends to spread poorly, and if it exceeds 8 million, it becomes technically difficult to keep the content of compounds with a molecular weight of 10 million or more to 10 mass% or less.

[0015] In addition, (ii) if the content of the compound having a molecular weight of 10 million or more is 10% by mass or less of the total amount of the (B) component, the stickiness caused by the (A) component can be suppressed, and the freshness and moistness after application can be sufficiently improved. On the other hand, if the ratio of the large compound having a molecular weight of 10 million or more exceeds 10% by mass, it tends to be difficult to suppress the deterioration of usability due to the incorporation of the (A) component. The main polymer chain of component (B) is preferably linear. Furthermore, the molecular weight distribution (= weight average molecular weight / number average molecular weight) of component (B) is preferably 2 or less, and more preferably 1.8 or less.

[0016] In this application, only polyacrylic acid or its salt will be specifically described, but even if it is a synthetic polymer compound other than these, if it satisfies the above conditions (i) and (ii), it is possible to reduce stickiness due to component (A) in the same way as component (B). Examples of monomers constituting such polymer compounds include acrylic acid-based monomers such as methacrylic acid, alkyl acrylate, alkyl methacrylate, and acrylic ester. In addition, macromonomers in which polyethylene glycol, silicone-based polymer compounds, etc. are added as side chains to the above monomers can also be suitably used as constituent units.

[0017] Examples of the salt include alkali metal salts (e.g., sodium salts, potassium salts, magnesium salts, calcium salts, etc.), organic amine salts (e.g., monoethanolamine salts, diethanolamine salts, triethanolamine salts, triisopropanolamine salts, etc.), and salts of basic nitrogen-containing compounds such as 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, L-arginine, L-lysine, and L-alkyltaurine. Among these, monovalent alkali metal salts and organic amine salts are preferred, more preferably sodium salts, potassium salts, and triethanolamine salts, and most preferably sodium salts.

[0018] The component (B) can be synthesized by a known living polymerization method. Among them, the reversible addition-fragmentation chain transfer polymerization method (RAFT polymerization method) is preferable because it is possible to synthesize a compound with a narrow molecular weight distribution. For details of the method for producing the component (B), the description in WO2015 / 052804 can be referred to.

[0019] The molecular weight of the component (B) can be measured by known methods such as light scattering, ultracentrifugation, and chromatography for the weight average molecular weight, and osmometry and chromatography for the number average molecular weight. Among these, chromatography is preferred because it allows the weight average molecular weight, number average molecular weight, and molecular weight distribution to be easily obtained with a small amount of sample, and gel permeation chromatography (hereinafter abbreviated as GPC) is more suitable. The molecular weight distribution can be expressed as the value obtained by dividing the weight average molecular weight obtained by GPC analysis by the number average molecular weight.

[0020] The content of the (B) component in the present invention is not particularly limited, but is preferably 0.001 to 0.5% by mass, more preferably 0.005 to 0.3% by mass, and even more preferably 0.01 to 0.2% by mass, based on the total amount of the cosmetic. Within this range, the effect of nicotinamide in improving rough skin, whitening effect, and anti-aging effect of the skin can be sufficiently obtained, while a cosmetic having a sufficiently excellent feeling in use, such as a fresh feeling during application and no stickiness on the skin after application, can be obtained.

[0021] <(C) Diglycerin> In addition to the above components (A) and (B), the present invention preferably optionally contains (C) diglycerin (hereinafter sometimes simply referred to as "component (C)"). The content of component (C) is not particularly limited, but is preferably 0.1 to 5 mass % relative to the total amount of the cosmetic, more preferably 0.3 to 3 mass %, and even more preferably 0.5 to 2 mass %. Blending component (C) within this range can further improve the sensation of use, such as a fresh feeling during application and a non-sticky feeling on the skin after application.

[0022] <(D) Sugar alcohol> Furthermore, in the present invention, it is preferable that the composition optionally contains (D) one or more sugar alcohols selected from mannitol, xylitol, erythritol, sorbitol, maltitol, and inositol (hereinafter, sometimes simply referred to as "component (D)"). Of these, maltitol and xylitol are most suitable. In addition, derivatives thereof, such as POE and / or POP adducts, alkyl group adducts, cationized products, anionized products, and silylated products, can also be used as component (D). In this specification, POE stands for polyoxyethylene, and POP stands for polyoxypropylene.

[0023] The content of component (D) in the present invention is not particularly limited, but is preferably 0.1 to 5 mass % relative to the total amount of the cosmetic, more preferably 0.3 to 3 mass %, and even more preferably 0.5 to 2 mass %. Blending component (D) within this range can further improve the sensation of use, such as freshness during application and non-stickiness on the skin after application.

[0024] <Other optional ingredients> The cosmetic preparation of the present invention may contain other ingredients, such as aqueous solvents, water-soluble polymers, oils, UV absorbers, moisturizers, medicines, as well as chelating agents, preservatives, antioxidants, powders, fragrances, coloring agents, pigments, etc., as necessary, within the scope of not impairing the effects of the present invention.

[0025] Examples of moisturizing agents include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, Dl-pyrrolidone carboxylate, alkylene oxide derivatives, short-chain soluble collagen, diglycerin (EO)PO adducts, etc. In this specification, EO stands for ethylene oxide, and PO stands for propylene oxide.

[0026] The oil is not particularly limited, and various oils widely used in cosmetics can be blended, regardless of whether they are solid oils or liquid oils.

[0027] The solid oil component is an oil component that is generally used in cosmetics and is solid or semi-solid at room temperature. Examples of such oil components include solid oils and fats such as cacao butter, coconut oil, horse oil, hardened coconut oil, palm oil, beef tallow, mutton oil, hardened beef tallow, palm kernel oil, lard, beef bone oil, Japan wax kernel oil, hardened oil, cow foot fat, Japan wax, and hardened castor oil; beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, Japanese laurel wax, whale wax, montan wax, rice bran wax, lanolin, kapok wax, lanolin acetate, sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, and jojoba wax. Examples of waxes include wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, and POE hydrogenated lanolin alcohol ether; hydrocarbon waxes such as polyethylene wax, paraffin wax, ceresin, petrolatum, microcrystalline wax, and Lunacera; fatty acid glyceryl ethers such as monostearyl glycerin ether (batyl alcohol); and fatty acid glycerides such as acetoglyceride and tri-2-heptylundecanoic acid glyceride. These may be used alone or in combination of two or more.

[0028] Liquid oils are oils that are generally used in cosmetics and are liquid at room temperature. Examples of such oils include liquid fats and oils such as avocado oil, evening primrose oil, camellia oil, turtle oil, macadamia nut oil, sunflower oil, almond oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba oil, and germ oil; cetyl octanoate, cetyl 2-ethylhexanoate, and dimethyl octanoate; Xyldecyl, Ethyl Laurate, Hexyl Laurate, Isopropyl Myristate, 2-Hexyldecyl Myristate, Myristyl Myristate, Octyldodecyl Myristate, Isopropyl Palmitate, 2-Ethylhexyl Palmitate, 2-Hexyldecyl Palmitate, 2-Heptylundecyl Palmitate, Butyl Stearate, Isocetyl Stearate, Isocetyl Isostearate, Decyl Oleate, Dodecyl Oleate, Oleyl Oleate, Myristyl Lactate, Cetyl Lactate , diisostearyl malate, cholesteryl 12-hydroxystearyl acid, castor oil fatty acid methyl ester, 2-ethylhexyl succinate, diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, diisopropyl sebacate, di-2-ethylhexyl sebacate, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, acetoglyceride, di-2-heptylundecane ester oils such as glycerin acid, glycerin trioctanoate, glycerin tri-2-ethylhexanoate, glycerin trimyristate, glycerin triisopalmitate, tri-2-heptylundecanoate glyceride, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetraoctanoate, and pentaerythritol tetra-2-ethylhexanoate; hydrocarbon oils such as liquid paraffin, squalene, pristane, and polybutene;Examples of silicone oils include chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and diphenylpolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane, and various modified polysiloxanes such as amino-modified polysiloxanes, polyether-modified polysiloxanes, alkyl-modified polysiloxanes, and fluorine-modified polysiloxanes, and these can be used alone or in combination of two or more kinds.

[0029] Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid; anthranilic acid-based ultraviolet absorbers such as methyl anthranilate; salicylic acid-based ultraviolet absorbers such as octyl salicylate; cinnamic acid-based ultraviolet absorbers such as isopropyl paramethoxycinnamate and octyl paramethoxycinnamate; pyridazine derivatives such as dimorpholinopyridazinone; benzoylmethane derivatives such as 4-methoxy-4'-t-butyldibenzoylmethane; 3-(4'-methylbenzylidene)-D,l-camphor, 3-benzoylmethane, 4-methoxy-4'-t-butyldi ... Examples of the compound include camphor derivatives such as dilidene-D,l-camphor; benzotriazole derivatives such as 2,2'-hydroxy-5-methylphenylbenzotriazole, 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole, and 2-(2'-hydroxy-5'-methylphenylbenzotriazole; and others include 2-phenyl-5-methylbenzoxazole; dibenzalazine; dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one.

[0030] Examples of drugs include ascorbic acid (vitamin C), tranexamic acid, kojic acid, ellagic acid, arbutin, alkoxysalicylic acid, glycyrrhizic acid, tocopherol, retinol, and salts or derivatives thereof (e.g., sodium L-ascorbate, magnesium L-ascorbate, L-ascorbic acid glucoside, 2-O-ethyl-L-ascorbic acid, 3-O-ethyl-L-ascorbic acid, sodium 4-methoxysalicylic acid, potassium 4-methoxysalicylic acid, dipotassium glycyrrhizinate, stearyl glycyrrhizinate, tocopherol acetate, retinol acetate, retinol palmitate, etc.).

[0031] Chelating agents include citramalic acid, agaric acid, glyceric acid, shikimic acid, hinokitiol, gallic acid, tannic acid, caffeic acid, ethylenediaminetetraacetic acid, ethyleneglycoldiaminetetraacetic acid, diethylenetriaminepentaacetic acid, phytic acid, polyphosphoric acid, metaphosphoric acid, and analogs, alkali metal salts, and carboxylate esters thereof.

[0032] Examples of preservatives include paraoxybenzoic acid esters such as methylparaben, ethylparaben, and butylparaben, benzoic acid, salicylic acid, sorbic acid, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizers, and phenoxyethanol.

[0033] Antioxidants include ascorbic acid, α-tocopherol, carotenoids, and the like.

[0034] The cosmetic according to the present invention can be widely applied in the form of medicines, quasi-drugs (ointments, etc.), face washes, lotions, milky lotions, creams, gels, essences (serums), packs, masks and other basic cosmetics, makeup cosmetics such as foundations and lipsticks, sun care products such as sunscreens, fragranced cosmetics, body cosmetics, etc. Note that these forms are merely examples, and the cosmetic according to the present invention is not limited to these forms. EXAMPLES

[0035] The present invention will be described in more detail below with reference to specific examples, but the present invention is not limited to the following examples. In addition, the blending amounts in the following examples are expressed as mass% relative to the total amount of the cosmetic unless otherwise specified. Before describing each example in detail, the evaluation methods and molecular weight measurement methods used will be described.

[0036] <Evaluation of usability> A panel of 10 experts applied the samples to their faces and evaluated them for usability (freshness during application, non-stickiness of skin after application, and moisturization of skin after application). Based on the evaluations of each expert panel, the samples were rated according to the following criteria.

[0037] (1) Freshness during application AAA: All 10 panelists answered that it felt fresh and moist. AA: Nine out of ten panelists said it felt fresh and moist. A: Between 7 and 9 out of 10 panelists answered that it felt fresh. B: Of the 10 panelists, between 5 and 7 answered that it felt fresh. C: Of the 10 panelists, between 3 and 5 answered that it felt fresh. D: Between 1 and 3 out of 10 panelists answered that it felt fresh. E: All 10 panelists answered that it lacked a fresh feel.

[0038] (2) No sticky feeling on the skin after application AAA: All 10 panelists answered that it was not sticky. AA: 9 out of 10 panelists said it was not sticky. A: Between 7 and 9 out of 10 panelists answered that it was not sticky. B: Between 5 and 7 out of 10 panelists answered that it was not sticky. C: Between 3 and 5 out of 10 panelists answered that it was not sticky. D: Between 1 and 3 out of 10 panelists answered that it was not sticky. E: All 10 panelists answered that it felt sticky.

[0039] (3) Moisturizing skin after application AAA: All 10 panelists answered that it made their skin feel moisturized. AA: 9 out of 10 panelists answered that it made their skin feel moisturized. A: Between 7 and 9 out of 10 panelists answered that it made their skin feel moisturized. B: Between 5 and 7 out of 10 panelists answered that the product made their skin feel moisturized. C: Between 3 and 5 out of 10 panelists answered that the product made their skin feel moisturized. D: Between 1 and 3 out of 10 panelists answered that the product made their skin feel moisturized. E: All 10 panelists answered that the product lacked moisture on the skin.

[0040] <Molecular weight measurement> The molecular weight of the sodium polyacrylate used was measured by GPC analysis under the following conditions. Guard column: Showdex OHpak SB-G, 1 piece (Showa Denko K.K.), Column: Shodex OHpak SB-804HQ, 2 pieces (Showa Denko K.K.), Column temperature: 40°C, Column oven: CTO-10ASVP (Shimadzu Corporation), Degassing device: ERC-3215α (manufactured by ERC Co., Ltd.), Pump: DP-8020 dual pump (manufactured by Tosoh Corporation), Refractive index detector: RI-8020 differential refractometer (manufactured by Tosoh Corporation), Elution solvent: 5 mM phosphate buffer (pH 8.0) + 90% acetonitrile Flow rate: 0.6ml / min, Injection volume: 10μl, Molecular weight standards: Standard sodium polystyrene sulfonate.

[0041] [Examples 1 to 15 and Comparative Examples 1 to 4] Aqueous cosmetic compositions having the compositions shown in Tables 1 and 2 below were prepared by standard methods and evaluated for the above items (1) to (3).

[0042] [Table 1]

[0043] [Table 2] *1: Sodium polyacrylate with a weight-average molecular weight of 2 million and a content of macromolecules with a molecular weight of 10 million or more of 10% by mass or less *2: Aronvis (registered trademark) SX (manufactured by Toagosei Co., Ltd.)

[0044] As shown in Tables 1 and 2, a cosmetic composition containing nicotinamide but not polyacrylic acid or its salt did not achieve sufficient results in any of the evaluation items (Comparative Example 1). In addition, when sodium polyacrylate (Aronvis (registered trademark) SX) having a weight-average molecular weight of 4 million to 5 million and containing more than 10 mass% of macromolecules with a molecular weight of 10 million or more was blended into this cosmetic composition, the moist feeling after application was slightly improved, but the stickiness was worsened (Comparative Example 2).

[0045] On the other hand, when sodium polyacrylate having a weight-average molecular weight of 2 million and a molecular weight controlled so that the content of macromolecules having a molecular weight of 10 million or more is 10 mass% or less was added, excellent results were obtained in all evaluation items (Examples 1 to 8). It was also confirmed that the feeling of use was significantly improved by further blending diglycerin or sugar alcohol (Examples 9 to 13). This significant improvement was not observed when diglycerin was replaced with simple glycerin (Comparison between Example 9 and Example 14) or when sugar alcohol was replaced with glucose, a simple sugar (Comparison between Examples 11 and 12 and Example 15), and is therefore considered to be an effect that is specific to diglycerin or sugar alcohol.

[0046] Furthermore, when ascorbyl glucoside, which is known to cause stickiness, was used instead of nicotinamide, no suppression of stickiness was observed, and no improvement was observed in moisturizing or freshness after application (Comparative Examples 3 and 4). From this, it is considered that the effect of improving stickiness, etc. by polyacrylic acid or its salt is specifically expressed by nicotinamide.

Claims

1. (A) nicotinamide, (B) polyacrylic acid or a salt thereof having a weight average molecular weight of 500,000 to 8,000,000 and a content of a compound having a molecular weight of 10,000,000 or more of 10% by mass or less; and (D) a sugar alcohol selected from maltitol and xylitol Including, The blending amount of the (D) component is 0.5 to 2% by mass based on the total amount of the cosmetic. Cosmetics.

2. The cosmetic according to claim 1, wherein the blending amount of the component (A) is 0.5 to 10% by mass based on the total amount of the cosmetic.

3. The cosmetic according to claim 1 or 2, wherein the blending amount of the component (B) is 0.001 to 0.5% by mass based on the total amount of the cosmetic.

4. The cosmetic preparation according to any one of claims 1 to 3, further comprising (C) diglycerin.

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