Oral composition

Abstract

To provide an oral cavity composition having an excellent balance between squeezability when squeezed out of a tube container and cushioning property when brushing teeth. [Solution] An oral composition containing an abrasive and a binder, in which, when the maximum pushing stress in a 3 mm push-in test is PF3, and the tensile stresses in a 5 mm tensile test and a 10 mm tensile test are TF5 and TF10, respectively, (PF3)*(TF5) is 50 (gf)^2 or more and less than 5000 (gf)^2, and TF10 is 4.0 gf or more and 50 gf or less.

Description

[Technical field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] A technology for improving the dischargeability of an oral composition from a storage container is described in Patent Document 1 (JP 2021-91654 A). The document describes a dentifrice composition containing one or more water-soluble polyvalent metal salts selected from water-soluble aluminum salts, water-soluble copper salts, and water-soluble zinc salts, xanthan gum, and a cationic polymer compound (Claim 1). According to the document, a dentifrice composition can be provided that has effects such as suppressing hypersensitivity, suppressing bad breath, and tightening gums due to the water-soluble polyvalent metal salt, and is excellent in moldability and easy to apply to a toothbrush, and is inhibited from hardening over time, making it easy to discharge from a storage container even after storage. This dentifrice composition can be formulated into a dentifrice composition that satisfactorily maintains the physical properties of the dentifrice composition, and has a relatively small amount of abrasive or is free of abrasives, ensuring a gentle brushing experience with low irritation, and is particularly useful for suppressing hypersensitivity or bad breath and tightening gums (paragraph 0011). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent Publication No. 2021-91654 DISCLOSURE OF THEINVENTION [Problem to be solved by the invention]

[0004] Through the inventors' research, it became clear that there is room for improvement in the product described in Patent Document 1 above, in terms of improving the ease of squeezing the product out of the tube container while also improving the cushioning effect when brushing teeth.

[0005] The present invention provides an oral composition that has an excellent balance between squeezability when squeezed out of a tube container and cushioning properties when brushing teeth. [Means for solving the problem]

[0006] According to the present invention, the following oral compositions are provided. [1] An oral composition comprising an abrasive and a binder, The maximum pushing stress in the 3 mm push-in test measured by the following method 1 is defined as PF3, and the pulling stress in the 5 mm tensile test and the 10 mm tensile test measured by the following method 2 are defined as TF5 and TF10, respectively. (PF3)*(TF5) is 50(gf)^2 or more and less than 5000(gf)^2, An oral composition having a TF10 of 4.0 gf or more and 50 gf or less. (Method 1) Device name: Rheometer Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Push-in distance: 3mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: The oral composition is filled into the filling container until it is full, and then the container is set in the device. The container is then pushed to the pushing distance at the measuring speed, and the maximum stress during the pushing is measured. The average value of three measurements is taken as the PF3. (Method 2) Device name: Rheometer Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Pull-up distance: 5mm or 10mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: Fill the filling container with the oral composition until it is full, set it in the device, and then pull it up at the measurement speed. Measure the absolute value of the stress at each pull-up distance. Measure three times at each pull-up distance and use the average value as the TF5 or TF10. [2] The oral composition described in [1], wherein the binder contains thickening silica. [3] The oral composition according to [1] or [2], wherein the binder comprises an organic binder. [4] The oral composition described in [3], wherein the organic binder is one or more selected from the group consisting of carboxymethylcellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymers, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan). [5] The oral composition described in any one of [1] to [4], wherein the abrasive contains abrasive silica. [6] An oral composition described in any one of [1] to [5], further comprising a humectant. [7] An oral composition described in any one of [1] to [6], which is a dentifrice composition. [8] An oral composition described in any one of [1] to [7], which is a toothpaste composition. [9] A dentifrice comprising the oral composition described in any one of [1] to [8] filled in a tube container.

[0007] Any combination of these configurations and conversion of the present invention between methods, devices, etc. are also valid aspects of the present invention. Effect of the Invention

[0008] According to the present invention, an oral composition can be obtained that has an excellent balance between the ease of squeezing it out of a tube container and cushioning properties when brushing teeth. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] Hereinafter, an embodiment of the present invention will be described. In this embodiment, the composition may contain each component alone or in combination of two or more kinds. In this specification, the symbol "to" indicating a numerical range means "greater than or equal to" or "less than or equal to," and both end numerical values ​​are included.

[0010] (Oral composition) In this embodiment, the oral composition includes an abrasive and a binder. When the maximum pushing stress in a 3 mm pushing test measured by the following method 1 is PF3, and the pulling stress in a 5 mm tensile test and a 10 mm tensile test measured by the following method 2 are TF5 and TF10, respectively, (PF3)*(TF5) is 50(gf)^2 or more and less than 5000(gf)^2, and TF10 is 4.0gf or more and 50gf or less.

[0011] (Method 1) Device name: Rheometer (e.g. CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Push-in distance: 3mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: Fill the filling container with the oral composition until it is full, set it in the device, and then push it to the pushing distance at the measuring speed to measure the maximum stress during pushing. The average value of three measurements is taken as PF3.

[0012] (Method 2) Device name: Rheometer (e.g. CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Pull-up distance: 5mm or 10mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: Fill the filling container with the oral composition until it is full, set it in the device, and then pull it up at the measurement speed to measure the absolute value of the stress at each pull-up distance. The average value of three measurements at each pull-up distance is TF5 or TF10. In the procedure of Method 2, the numerical value of the stress during pulling is negative, so the recorded value is negative and the absolute value is positive.

[0013] Here, the measurement temperature in Measurement 1 and Measurement 2 is specifically room temperature (25° C.).

[0014] The present inventors have investigated the compositional components and physical properties as design guidelines for improving the balance between the ease of squeezing an oral composition from a tube container when the composition is filled in the tube and the cushioning effect during tooth brushing. As a result, the inventors have newly discovered that by controlling the compositional components of the oral composition and using (PF3)*(TF5) and TF10 as indicators, the oral composition filled in the tube container can be made easy to squeeze out of the tube container, while the oral composition can provide suitable cushioning effect on the surfaces of teeth and gums during tooth brushing, thereby achieving a favorable balance between these effects. That is, in this embodiment, the oral composition contains a combination of an abrasive and a binder, and (PF3)*(TF5) and TF10 are each within a specific range, so that the balance between the squeezeability when squeezed out of the tube container and the cushioning property when brushing teeth is excellent. This also makes it possible to obtain an oral composition that is easy to handle and has a good feel when used in the oral cavity. For example, it is possible to reduce the feeling of excessive hardness when the oral composition is squeezed out of the tube container, and to suitably reduce dripping from the discharge port. It is also possible to improve the controllability of the discharge amount of the oral composition squeezed out of the tube container. For example, when the oral composition is used together with a toothbrush, it is possible to reduce the feeling of irritation while providing a moderate massage with the toothbrush.

[0015] The product of the maximum pushing stress PF3 in the 3 mm pushing test and the pulling stress TF5 in the 5 mm tensile test, i.e., (PF3)*(TF5), is 50(gf)^2 or more, preferably 80(gf)^2 or more, more preferably 100(gf)^2 or more, even more preferably 150(gf)^2 or more, and even more preferably 200(gf)^2 or more. This can reduce the dripping of the oral composition filled in the tube container from the discharge port. In addition, the cushioning property during tooth brushing can be made more preferable. In addition, the massage feeling by the toothbrush can be made more preferable. The product of the stresses (PF3)*(TF5) is less than 5000(gf)^2, preferably 4000(gf)^2 or less, more preferably 3000(gf)^2 or less, even more preferably 2500(gf)^2 or less, even more preferably 2000(gf)^2 or less, and may be 1000(gf)^2 or less. This can reduce the feeling of excessive hardness when squeezing out the oral composition filled in the tube container. In addition, the oral composition can be excellently spread in the oral cavity.

[0016] PF3 is preferably 10 gf or more, more preferably 20 gf or more, even more preferably 30 gf or more, and even more preferably 40 gf or more, which can provide a more preferable sharpness when discharging the oral composition filled in the tube container. Also, PF3 is preferably 130gf or less, more preferably 100gf or less, even more preferably 80gf or less, and even more preferably 60gf or less. This can further improve the ejection property when squeezing out the oral composition filled in the tube container. Also, the usability of the oral composition can be improved.

[0017] TF5 can be a value such that (PF3)*(TF5) is in the above-mentioned range. TF5 may be, for example, 7 g or more, and may be, for example, 40 g or less.

[0018] The tensile stress TF10 in a 10 mm tensile test is 4.0 gf or more, preferably 5.0 gf or more, and more preferably 6.0 gf or more. This improves the cushioning effect when brushing teeth. Also, the massage feeling when brushing teeth can be more preferable. Also, TF10 is 50gf or less, preferably 40gf or less, more preferably 35gf or less, even more preferably 30gf or less, even more preferably 25gf or less, and even more preferably 20gf or less. This can improve the cushioning property when brushing teeth. Also, when the oral cavity composition is used together with a toothbrush, the irritation caused by the toothbrush can be reduced.

[0019] Next, the components of the oral composition will be described. The oral composition includes an abrasive and a binder as described above.

[0020] (Abrasive) Examples of the abrasives include one or more selected from the group consisting of abrasive silica such as hydrous silicic acid (e.g., gel-processed silica, precipitated silica), anhydrous silicic acid, silica gel, and aluminosilicate; zeolites; calcium phosphate-based abrasives such as calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, and calcium pyrophosphate; calcium carbonate-based abrasives such as calcium carbonate; and other inorganic abrasives such as aluminum hydroxide, alumina, magnesium carbonate, magnesium triphosphate, zirconium silicate, calcium triphosphate, hydroxyapatite, and calcium quaternary phosphate; and organic abrasives such as synthetic resin-based abrasives.

[0021] The abrasive preferably contains abrasive silica, more preferably contains hydrated silicic acid. It is also preferable that the abrasive contains anhydrous silicic acid. This makes it possible to more stably improve the balance between the ease of squeezing the powder from the tube container and the cushioning effect during tooth brushing. The abrasive silica may be either crystalline silica or amorphous silica, or may be wet silica.

[0022] The average particle size of the abrasive silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 3 μm or more, even more preferably 5 μm or more, and even more preferably 8 μm or more, so that the stains on the tooth surface can be efficiently removed. The average particle size of the abrasive silica is preferably 50 μm or less, more preferably 30 μm or less, and even more preferably 20 μm or less, thereby making it possible to obtain an oral composition that is smooth to the touch.

[0023] Here, the average particle size of the abrasive silica and the thickening silica described below is determined by measuring the particle size distribution of the particles on a volume basis using a commercially available laser diffraction / scattering type particle size distribution measuring device. 50 It can be said that:

[0024] It is also preferable that the abrasive is substantially free of calcium carbonate, which makes it possible to more stably improve the balance between the ease of squeezing the powder from the tube container and the cushioning effect during tooth brushing. Here, the oral composition not containing calcium carbonate specifically means that calcium carbonate is not intentionally blended into the oral composition, and more specifically means that the calcium carbonate content is 0.001 mass% or less based on the entire oral composition.

[0025] The content of the abrasive in the oral composition is preferably 5% by mass or more, more preferably more than 5% by mass, even more preferably more than 10% by mass, even more preferably more than 10% by mass, even more preferably more than 11% by mass, and even more preferably more than 13% by mass, based on the total amount of the oral composition. This allows for efficient removal of stains on the tooth surface. The content of the abrasive in the oral composition is preferably 30% by mass or less, more preferably less than 30% by mass, even more preferably 25% by mass or less, and even more preferably 20% by mass or less, based on the total amount of the oral composition. This makes it possible to obtain an oral composition that is excellent in smoothness when used.

[0026] (Binding agent) Examples of the binder include at least one selected from the group consisting of thickening silica such as hydrated silicic acid (e.g., gel-processed silica and precipitated silica) and anhydrous silicic acid (e.g., gel-processed silica, precipitated silica, and dry silica); other inorganic binders such as bentonite; and organic binders such as pullulan, gelatin, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts thereof, carrageenan, alginic acid and salts thereof, xanthan gum, polyacrylic acid and salts thereof, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, and carboxyvinyl polymers. Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts.

[0027] The binder preferably contains an inorganic binder, and more preferably contains thickening silica, which can more stably improve the balance between the squeezability when squeezed out of the tube container and the cushioning property when brushing teeth.

[0028] The thickening silica may be either crystalline silica or amorphous silica, and may be either dry silica or wet silica. The average particle size of the thickening silica is, for example, preferably 1 μm or more, more preferably 2 μm or more, even more preferably 5 μm or more, and even more preferably 10 μm or more, which allows the viscosity of the oral composition to be more efficiently maintained. The average particle size of the thickening silica is preferably 60 μm or less, more preferably 50 μm or less, and further preferably 40 μm or less, thereby making it possible to obtain an oral composition that is excellent in smoothness when used.

[0029] The oil absorption of the thickening silica, which is determined by the amount of boiled linseed oil absorbed according to the method described in JIS K 5101-13-2 (2004), is, for example, 0.1 mL / g or more, preferably 0.2 mL / g or more, and, for example, 5 mL / g or less, preferably 4 mL / g or less.

[0030] The content of the inorganic binder in the oral composition is preferably 2% by mass or more, more preferably 2.5% by mass or more, even more preferably 3% by mass or more, and even more preferably 4% by mass or more, based on the total oral composition. This makes it possible to obtain an oral composition with better cushioning properties when brushing teeth. This also reduces irritation caused by the contact of the toothbrush with the teeth, gums, etc. The content of the inorganic binder in the oral composition is preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 20% by mass or less, and even more preferably 15% by mass or less, based on the total amount of the oral composition, thereby making it possible to obtain an oral composition having excellent surface smoothness.

[0031] The binder preferably contains an organic binder. When the binder contains thickening silica, it is preferable that the binder further contains an organic binder. This makes it possible to more stably improve the balance between the squeezability when squeezing the powder from the tube container and the cushioning effect when brushing teeth.

[0032] In view of the above, the organic binder preferably comprises one or more selected from the group consisting of carboxymethylcellulose and its salts (e.g., sodium carboxymethylcellulose), xanthan gum, alginic acid and its salts (e.g., sodium alginate), polyacrylic acid and its salts, carboxyvinyl polymers, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (preferably excluding κ-carrageenan, e.g., ι-carrageenan); More preferably, it contains one or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose and xanthan gum; More preferably, it contains two or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; Even more preferably, it comprises sodium alginate or sodium carboxymethylcellulose and xanthan gum; Even more preferably, it contains sodium alginate and xanthan gum. Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts.

[0033] On the other hand, in terms of facilitating rinsing the oral cavity, it is also preferable that the oral composition does not contain xanthan gum. Specifically, the oral composition does not contain xanthan gum means that xanthan gum is not intentionally blended into the oral composition, and more specifically, the content of xanthan gum is 0.001% by mass or less based on the entire oral composition.

[0034] The content of the organic binder in the oral composition is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, and even more preferably 1% by mass or more, based on the total amount of the oral composition, which allows the oral composition to have an appropriate viscosity. The content of the organic binder in the oral composition is preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total oral composition, which allows for an oral composition that is easy to squeeze out of a tube container.

[0035] The mass ratio of the organic binder content to the inorganic binder content in the oral cavity composition (organic binder / inorganic binder) is preferably 0.05 or more, more preferably 0.1 or more, and even more preferably 0.2 or more, thereby making it possible to obtain an oral cavity composition that is smooth to the touch and has an excellent usability. Moreover, the mass ratio (organic binder / inorganic binder) is preferably 2.0 or less, more preferably 1.75 or less, even more preferably 1.5 or less, even more preferably 1.25 or less, and even more preferably 0.9 or less, whereby an oral composition that is excellent in sharpness when taken out of a tube container onto a toothbrush or the like can be obtained. The total content of the binder in the oral composition is preferably 2% by mass or more, more preferably 3% by mass or more, and even more preferably 5% by mass or more, based on the total oral composition, which allows the oral composition to have an appropriate viscosity. The total content of the binder in the oral composition is, for example, 45% by mass or less, preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the entire oral composition. This makes it possible to obtain an oral composition that is more compatible with saliva during tooth brushing. Also, excessive thickening of the oral composition can be suppressed.

[0036] The total content of silica in the oral composition is preferably 10% by mass or more, more preferably 15% by mass or more, and even more preferably 20% by mass or more, based on the total oral composition, which can appropriately suppress the fluidity of the oral composition. The total content of silica in the oral composition is, for example, 60% by mass or less, preferably 30% by mass or less, more preferably 27.5% by mass or less, and even more preferably 25% by mass or less, based on the total oral composition. This makes it possible to obtain an oral composition that is more compatible with saliva in the oral cavity, for example, when brushing teeth.

[0037] (Other ingredients) The oral composition may further contain ingredients other than those mentioned above, such as medicinal ingredients, thickeners, surfactants, humectants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, detergents, adsorbents, etc., which may be appropriately selected depending on the dosage form.

[0038] Examples of the medicinal ingredient include one or more selected from the group consisting of bactericides, anti-inflammatory agents, blood circulation promoters, tartar deposition inhibitors, stain removers, hypersensitivity inhibitors, vitamins, and plaque decomposing enzymes. There is no limitation on these medicinal ingredients as long as they can be used in medicines, etc.

[0039] Among the medicinal ingredients, examples of the bactericide include one or more selected from the group consisting of isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroyl sarcosine, and triclosan.

[0040] Examples of the anti-inflammatory agent include one or more selected from the group consisting of tranexamic acid, β-glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizinic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, stearyl glycyrrhetinate, ε-aminocaproic acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterol, dihydrocholesterol, and lysozyme hydrochloride.

[0041] Examples of the blood circulation promoter include one or more selected from the group consisting of sodium chloride, tocopherol acetate, sodium bicarbonate, sodium hydrogen carbonate, and tocopherol nicotinate.

[0042] Examples of tartar deposit inhibitors include one or more selected from the group consisting of disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, sodium hydrogen phosphate hydrate, disodium hydrogen phosphate (crystalline), trisodium phosphate, and sodium polyphosphate.

[0043] Examples of stain removers include one or more selected from the group consisting of macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000, etc.), sodium polyphosphate, and polyvinylpyrrolidone.

[0044] The dentin hypersensitivity suppressant may, for example, be at least one selected from the group consisting of potassium nitrate and water-soluble aluminum salts.

[0045] Examples of vitamin preparations include one or more selected from the group consisting of vitamin C and derivatives thereof, such as ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, magnesium L-ascorbyl phosphate, pyridoxine hydrochloride, L-ascorbic acid 2-glucoside, ascorbyl tetra-2-hexyldecanoate, trisodium ascorbyl palmitate phosphate, 3-O-ethyl ascorbic acid, tocopherol, disodium isostearyl ascorbyl phosphate, and caprylyl 2-glyceryl ascorbate; and vitamin E and derivatives thereof, such as DL-α-tocopherol acetate, tocopherol acetate, dl-α-tocopherol nicotinate, and tocopherol nicotinate.

[0046] An example of a plaque decomposing enzyme is dextranase.

[0047] The thickening agent may be, for example, one commercially available as a pharmaceutical, food, or cosmetic raw material. The thickening agent may, for example, be one or more selected from the group consisting of polyhydric alcohols, more specifically sorbitol (sorbitol), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, trehalose, sodium hyaluronate, and hydrolyzed collagen.

[0048] Examples of the surfactant include anionic surfactants such as N-acylamino acid salts, α-olefin sulfonates, N-acylsulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters; Nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and glycerin fatty acid esters; and Examples of the surfactant include one or more selected from the group consisting of amphoteric surfactants such as alkyl betaine surfactants (e.g., coconut oil fatty acid amido alkyl betaine), amine oxide surfactants, and imidazolinium betaine surfactants (e.g., 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine). The surfactant may be a foaming agent.

[0049] The content of the surfactant in the oral composition is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and even more preferably 1% by mass or more, based on the total amount of the oral composition, thereby making it possible to obtain an oral composition that foams appropriately when brushing teeth. The content of the surfactant in the oral composition is preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less, based on the total amount of the oral composition. This makes it possible to obtain an oral composition with a cleaning power that does not remove too much oil from the oral cavity.

[0050] It is preferable that the oral composition further contains a humectant, which can provide the oral composition with better manufacturing stability. The humectant may be any one that is commercially available as a pharmaceutical, food, or cosmetic ingredient, such as a polyhydric alcohol, and more specifically, one or more selected from the group consisting of sorbitol, glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, sodium hyaluronate, and hydrolyzed collagen.

[0051] From the viewpoint of reducing irritation to the oral cavity, the humectant is preferably at least one selected from the group consisting of sorbitol, concentrated glycerin, and propylene glycol, and more preferably sorbitol or concentrated glycerin.

[0052] The content of the humectant in the oral composition is preferably 5% by mass or more, more preferably 10% by mass or more, and even more preferably 20% by mass or more, based on the total amount of the oral composition, thereby making it possible to obtain an oral composition having excellent moisturizing power in the oral cavity. The content of the humectant in the oral composition is preferably 50% by mass or less, more preferably 45% by mass or less, and even more preferably 40% by mass or less, based on the total oral composition. This makes it possible to obtain an oral composition that is easy to rinse with gargle.

[0053] Examples of flavoring agents include one or more selected from the group consisting of sodium L-glutamate, saccharin, saccharin sodium, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, inositol, D-sorbitol, D-mannitol, arabitol, raffinose, lactulose, lactitol, xylitol, erythritol, reduced palatinose, palatinose, Palatinit (registered trademark), acesulfame K, trehalose, maltose, maltosyl trehalose or maltitol, neohesperidin dihydrochalcone, perillartine, p-methoxycinnamic aldehyde, and thaumatin.

[0054] The flavoring agent is preferably at least one selected from the group consisting of xylitol, sodium saccharin, and saccharin, and more preferably at least one selected from the group consisting of xylitol and sodium saccharin, because it has a strong sweetness and can be used to adjust the taste even in small amounts.

[0055] Examples of preservatives include one or more selected from the group consisting of paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol; sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, alkyldiaminoethylglycine hydrochloride, and ethylhexylglycerin. Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts; and alkaline earth metal salts such as calcium salts and magnesium salts.

[0056] The flavoring agent may, for example, be one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavorings, and peppermint oil.

[0057] Examples of colorants include one or more selected from the group consisting of natural colorants such as safflower red colorant, gardenia yellow colorant, gardenia blue colorant, perilla colorant, red koji colorant, red cabbage colorant, carrot colorant, hibiscus colorant, cacao colorant, spirulina blue colorant, and coumarind colorant; legal colorants such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1; riboflavin, and titanium dioxide.

[0058] Examples of pH adjusters include one or more selected from the group consisting of acids and alkalis and buffers, such as acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate.

[0059] Solvents include water; and lower alcohols such as ethanol, propanol, etc. The solvent may be a liquid base.

[0060] The content of water in the oral composition can be, for example, the remainder after removing the components other than water from the oral composition. The content of water in the oral composition can be, for example, 30 to 80% by mass, and preferably 32 to 70% by mass, based on the entire oral composition. It is also preferable that the oral composition does not contain ethanol, i.e., the ethanol content is 0% by mass, or the oral composition contains ethanol but the ethanol content is 5% by mass or less, which can suppress strong irritation in the oral cavity.

[0061] A solubilizer may be added to promote dissolution of the additives and medicinal ingredients in water. Examples of such solubilizers include polyhydric alcohols such as dipropylene glycol.

[0062] Other bases include, for example, sodium bicarbonate.

[0063] Detergents include, for example, sodium polyphosphate.

[0064] The adsorbent may, for example, be β-cyclodextrin.

[0065] Furthermore, in addition to the above-mentioned components, components generally suitable for use in oral compositions can also be appropriately blended within the scope of the present invention.

[0066] (Dosage form, etc.) Specific examples of oral compositions include dentifrices such as toothpaste. In addition, the oral composition is preferably a dentifrice composition, more preferably a toothpaste composition, which can further improve the ease of handling of the oral composition. From the same viewpoint, the oral composition is preferably in a paste or gel form.

[0067] The oral composition is preferably applied to the oral cavity by being placed on a toothbrush. The toothbrush to be used with the oral composition may be, for example, a known one. The toothbrush to be used with the oral composition may be a typical commercially available toothbrush.

[0068] (Manufacturing method) In this embodiment, the oral composition includes a step of blending, for example, an abrasive, a binder, and other ingredients as appropriate. Here, in order to obtain an oral composition in which (PF3)*(TF5) and TF10 are each within a specific range, it is important to appropriately select, for example, the components contained in the oral composition and their blending ratios, as well as to appropriately select the manufacturing process for the oral composition. For example, it is important to appropriately select and combine the types and amounts of abrasives and binders contained in the oral composition to design the composition, and it is preferable to use a combination of abrasive silica and an inorganic binder, and more preferable to use a combination of abrasive silica and a thickening silica. It is also preferable to further add an organic binder to the oral composition. It is also preferable to further add a humectant to the oral composition. It is also preferable to carry out the manufacturing process of the oral composition under vacuum. For example, when the oral composition contains thickening silica, an organic binder, a humectant, and water, it is preferable to add thickening silica, an abrasive, and other components as appropriate during or after mixing the humectant, the organic binder, and the water, and stir and mix until uniform. It is also preferable to prepare a mixture of a part of the humectant and the organic binder in advance, add the mixture at the stage where the mixture is homogenized, and stir until further homogenized. It is more preferable to carry out these steps under vacuum.

[0069] (Toothpaste) In this embodiment, the dentifrice is the above-mentioned oral composition filled in a tube container, and preferably is a toothpaste composition filled in a tube container. In this embodiment, the oral composition has an excellent balance between the ease of squeezing it out of a tube container and the cushioning effect during tooth brushing, and by filling this into a tube container to prepare a dentifrice, it is possible to obtain excellent squeezing properties from the tube container. Furthermore, the squeezed dentifrice provides a pleasant cushioning effect in the oral cavity.

[0070] Oral compositions such as toothpaste compositions are preferably used by squeezing them out of a tube container. As the tube container, for example, a known container can be used. The material of the tube container may be one or more selected from the group consisting of resin materials such as polyethylene, polypropylene, polyethylene terephthalate, nylon, and metal materials such as aluminum. For example, the tube container may be a single-layer or multi-layer container made of these materials. The material of the innermost layer of the container is preferably one or more selected from the group consisting of polyethylene, polypropylene, and polyethylene terephthalate. For example, an aluminum laminated tube container may be used in which the material of the innermost layer of the container is polyethylene and further includes an aluminum layer.

[0071] The inner diameter of the discharge port of the tube container is preferably 1 mm or more, more preferably 2 mm or more, and further preferably 3 mm or more, which makes it possible to more stably reduce the excessive force required to discharge the oral composition. The inner diameter of the discharge port of the tube container is preferably 11 mm or less, more preferably 10 mm or less, and further preferably 9 mm or less, which can efficiently prevent dripping. The length of the tube container excluding the discharge port may be about 50 to 160 mm, and the outer circumferential length in the width direction of the tube container may be about 20 to 120 mm.

[0072] Although the embodiments of the present invention have been described above, these are merely examples of the present invention, and various configurations other than those described above can also be adopted. EXAMPLES

[0073] The present embodiment will be specifically described below with reference to examples and comparative examples, but the present embodiment is not limited to these examples.

[0074] (Examples 1 to 15, Comparative Examples 1 to 3) In this example, oral compositions, which are toothpaste compositions, were prepared and evaluated. The formulations, measurements, and evaluation results of each example are shown in Tables 1 to 3. The formulations of each component in these tables are in mass %, and the particle size of silica is the average particle size. Details of the components listed in Tables 1 to 3 are shown below. Sorbitol Kao: 70% sorbitol liquid, manufactured by Kao Corporation Concentrated glycerin for cosmetics: Concentrated glycerin, manufactured by Sakamoto Pharmaceutical Co., Ltd. Sodium alginate SHG: Sodium alginate, manufactured by Kohara Co., Ltd. NIKKOL SLS: Sodium lauryl sulfate, manufactured by Nikko Chemicals Caustic soda (48%): Sodium hydroxide solution, manufactured by Tatsumi Synthetic Chemical Co., Ltd.

[0075] (Preparation of oral composition) Sorbitol or glycerin and purified water were weighed into a beaker, and the organic binder was gradually added while stirring at 2500 rpm at 80°C using an emulsifying and dispersing device (Labo-lution, Primix) and a stirring section (Homodisper 2.5, Primix). After stirring and mixing for 3 minutes, abrasive silica, thickening silica (oil absorption 2.5 mL / g), sodium lauryl sulfate, and caustic soda were added in that order, stirring and mixing with a rubber spatula each time until the mixture was uniform.

[0076] (Rheometer push test) PF3 was measured at 25°C using Method 1 described above. Equipment name: Rheometer (CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Push-in distance: 3mm Filling container: 30mL plastic jar (diameter 43mm) The maximum stress during indentation was measured three times and the average value was calculated.

[0077] (Rheometer pull test) TF5 and TF10 were measured at 25°C using Method 2 described above. Device name: Rheometer (CR-3000EX-S, Sun Scientific, detection limit: 0.1 gf) Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Pull-up distance: 5mm or 10mm Filling container: 30mL plastic jar (diameter 43mm) The stress at each pulling distance was measured three times and the average was calculated. Although the measured values ​​were negative, the absolute values ​​(positive values) were used to compare the magnitude of the force.

[0078] (Evaluation method) (Easy to squeeze out) The toothpaste composition of each example was evaluated for ease of squeezing out of the tube container according to the following criteria, with A to C being deemed acceptable. A laminated tube (40Φ One-touch Tube-124.6, Takemoto Container Co., Ltd.) made of low-density polyethylene (LDPE), with a diameter of 19 mm and a size of 40Φ×130H, was used as the tube container. A one-touch cap (T-40Φ One-touch CAPII, Takemoto Container Co., Ltd.) made of polypropylene, with a diameter of 6 mm and a size of 39Φ×24H, was used as the cap. This was placed on a horizontal surface at room temperature (25° C.), and one evaluator slowly pressed the center of the tube container with the pads of his index finger and middle finger to discharge the composition, and the ease of squeezing was evaluated. A: Moderate pressure and easy to squeeze B: A little loose, but no problem with use C: Loose and prone to dripping from the mouth, but usable D: Hard and difficult to squeeze out

[0079] (Cushioning) The toothpaste composition of each example was filled into a tube container used for the evaluation of ease of squeezing. A toothbrush (manufactured by Lion Corporation) with a head size of 18 mm and bristles made of saturated polyester resin was used to take a 1.5 cm length of each toothpaste composition, and three evaluators applied it to the entire teeth. When applying, the softness of the toothbrush on the gums and tooth surface was evaluated by consensus according to the following criteria, with A to C being considered as passing. A: It feels soft to the touch. B: Feels a little soft C: I feel a slight change in the feel D: I don't feel any softness at all

[0080] [Table 1]

[0081] [Table 2]

[0082] [Table 3]

Claims

1. An oral composition comprising an abrasive, a binder and a humectant, the abrasive comprises abrasive silica; The binder comprises at least one selected from the group consisting of xanthan gum, sodium alginate, and thickening silica; The humectant comprises at least one selected from the group consisting of sorbitol and glycerin; The maximum pushing stress in the 3 mm pushing test measured by the following method 1 is defined as PF3, and the pulling stress in the 5 mm tensile test and the 10 mm tensile test measured by the following method 2 are defined as TF5 and TF10, respectively. (PF3) * (TF5) is equal to or greater than 50 (gf)^2 and less than 5000 (gf)^2, An oral composition having a TF10 of 4.0 gf or more and 50 gf or less. (Method 1) Device name: Rheometer Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20 mm) Measurement speed: 60mm / min Push-in distance: 3 mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: The oral composition is filled into the filling container until it is full, and then the container is set in the device. The container is then pushed to the pushing distance at the measuring speed, and the maximum stress during the pushing is measured. The average value of three measurements is taken as the PF3. (Method 2) Device name: Rheometer Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20 mm) Measurement speed: 60mm / min Pull-up distance: 5mm or 10mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: The oral composition is filled into the filling container until it is full, and then the container is set in the device. The container is pulled up at the measurement speed, and the absolute value of the stress at each pulling distance is measured. The average value of three measurements at each pulling distance is designated as TF5 or TF10.

2. An oral composition as described in claim 1, wherein the content of the binder in the oral composition is 2% by mass or more and 45% by mass or less relative to the entire oral composition.

3. The oral composition of claim 1 or 2, wherein the binder comprises an organic binder.

4. An oral composition as described in claim 3, wherein the content of the organic binder in the oral composition is 0.2 mass% or more and 15 mass% or less with respect to the entire oral composition.

5. An oral composition as described in claim 1 or 2, wherein the content of the abrasive in the oral composition is 5% by mass or more and 30% by mass or less relative to the entire oral composition.

6. An oral composition as described in claim 1 or 2, wherein the content of the humectant in the oral composition is 5% by mass or more and 50% by mass or less relative to the entire oral composition.

7. 3. The oral composition according to claim 1 or 2, which is a dentifrice composition.

8. 3. The oral composition according to claim 1, which is a toothpaste composition.

9. An oral composition as described in claim 1 or 2, wherein PF3 is 10 gf or more and 130 gf or less.

10. A dentifrice comprising the oral composition according to claim 8 packed in a tube container.

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