Stroke treatment support system

Abstract

To provide a cerebral infarction treatment support system which can present support information useful for a doctor to specify the type of cerebral infarction when the doctor examines or treats acute cerebral infarction.SOLUTION: A cerebral infarction treatment support system 100 includes: a detector 10 for measuring a biological sample 2 taken from a patient 1 and generating first information 41 as to whether the biological sample 2 has a sensitive gene to cerebral infarction: and a server 50 configured to be communicable with the detector 10, receiving information based on the presence or absence of the sensitive gene, associating the information based on the presence or absence of the sensitive gene and information related to the patient to each other, and managing the information.SELECTED DRAWING: Figure 2

Description

[Technical field]

[0001] The present invention relates to a cerebral infarction treatment support system and a cerebral infarction treatment support method, and more particularly to a cerebral infarction treatment support system that supports the diagnosis and treatment of patients with acute cerebral infarction. [Background technology]

[0002] A device for assisting in the diagnosis and treatment of acute cerebral infarction patients is known. Such a device is disclosed in Japanese Patent No. 4509531.

[0003] The above-mentioned Japanese Patent No. 4509531 discloses an acute cerebral infarction diagnosis and treatment support device incorporated in an X-ray computed tomography device. The acute cerebral infarction diagnosis and treatment support device of the above-mentioned Japanese Patent No. 4509531 provides a contrast-enhanced image obtained by subjecting a CT image obtained by non-contrast CT imaging to threshold processing and clustering processing, and a cerebral blood flow image obtained by processing continuous images obtained by dynamic CT imaging, which quantitatively represents the blood flow dynamics of capillaries in brain tissue, and displays a first ROI identified from the contrast-enhanced image and a second ROI identified from the cerebral blood flow image superimposed on the above-mentioned CT image. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent No. 4509531 Summary of the Invention [Problem to be solved by the invention]

[0005] For patients in the acute phase of cerebral infarction, diagnosis and treatment are typically performed in the following order (1) to (4). (1) A CT (Computed Tomography) image as disclosed in the above-mentioned Japanese Patent No. 4509531 or an MRI (Magnetic Resonance Imaging) image is taken of the patient's head. (2) Based on the images taken, a diagnosis is made, such as determining the type of cerebral infarction and pinpointing the location of the blood clot. (3) Drug treatment such as thrombolytic agents to dissolve the thrombus is attempted. (4) If necessary, thrombus removal will be performed using catheter therapy (endovascular therapy).

[0006] Cerebral infarction is classified into three types: cardiogenic cerebral embolism, lacunar infarction, and atherothrombotic cerebral infarction. There are several types of therapeutic devices used in catheter treatment for cerebral infarction, and the device is selected according to the type of cerebral infarction that has occurred.

[0007] However, conventionally, the type of cerebral infarction is judged by a doctor visually from CT images or MRI images, which requires skill and has the problem that it is difficult to identify the type of cerebral infarction. In addition, the doctor who identifies the type of cerebral infarction may be different from the doctor who performs the catheter treatment. Since the treatment of a cerebral infarction patient is highly urgent, there is no time to prepare documents, etc., and the type of cerebral infarction is likely to be communicated verbally to the doctor who performs the treatment. In addition to the low reliability of verbal communication, there is a problem that there is no way to confirm the type of cerebral infarction again during catheter treatment to select a treatment device.

[0008] Therefore, it is desirable to be able to present support information that will help doctors identify the type of cerebral infarction when diagnosing or treating acute cerebral infarction, separate from image information such as CT or MRI.

[0009] The present invention has been made to solve the above-mentioned problems, and one object of the present invention is to provide a cerebral infarction treatment support system that can present support information useful for doctors to identify the type of cerebral infarction when diagnosing and treating acute cerebral infarction. [Means for solving the problem]

[0010] In order to achieve the above object, the present inventors conducted extensive research and found that the presence or absence of a specific human gene is significantly correlated with a susceptibility gene for identifying the type of cerebral infarction, leading to the invention described below. That is, a cerebral infarction treatment support system in one aspect of the present invention measures a biological sample collected from a patient and generates first information on whether or not the biological sample has a susceptibility gene related to cerebral infarction. At the same time, patient information of the patient is added to the first information. The device comprises a detection device and a management unit configured to be able to communicate with the detection device, receiving information based on the presence or absence of a susceptibility gene, and managing the information based on the presence or absence of the susceptibility gene in association with information linked to the patient.

[0011] In this specification, the second information is information related to cerebral infarction that can be derived from the first information on whether or not a patient has a susceptibility gene for cerebral infarction and medical and scientific knowledge on the susceptibility gene. Effect of the Invention

[0012] In one aspect of the cerebral infarction treatment support system, the above configuration allows information on whether or not a patient has a susceptibility gene for cerebral infarction when treating a patient with acute cerebral infarction to be displayed on a display unit arranged in an image reading room where the type of cerebral infarction is determined and the location of the thrombus is identified. As a result, if information is displayed at the time of diagnosis where the type of cerebral infarction is determined and the location of the thrombus is identified, the doctor can determine the type of cerebral infarction by taking into account information based on the presence or absence of susceptibility genes that cannot be obtained from image information, in addition to conventional image reading using CT images and MRI images. In addition, if information is displayed on a display unit arranged in a catheterization room where a patient with cerebral infarction is treated, the doctor who actually performs the treatment can select a treatment device for catheterization treatment according to the type of cerebral infarction by taking into account information based on the presence or absence of susceptibility genes. As described above, support information useful for doctors to identify the type of cerebral infarction when diagnosing and treating acute cerebral infarction can be presented. [Brief description of the drawings]

[0013] [Figure 1]1 is a schematic diagram showing the overall configuration of a cerebral infarction treatment support system. [Diagram 2] FIG. 2 is a schematic diagram showing a configuration example of a detection device. [Diagram 3] 6A to 6F are diagrams for explaining the detection results of the detection device. [Figure 4] FIG. 11 is a diagram for explaining second information. [Diagram 5] FIG. 1 is a schematic diagram showing types of treatment devices. [Figure 6] FIG. 2 is a diagram showing examples of first information and second information. [Figure 7] FIG. 1 is a diagram illustrating an example of the configuration of a cerebral infarction treatment support system. [Figure 8] FIG. 1 is a flow chart for explaining the treatment process for acute cerebral infarction patients. [Figure 9] FIG. 1 is a flow chart showing a method for supporting cerebral infarction treatment. [Figure 10] 1 is a schematic diagram for explaining information linkage between each server and modality in a cerebral infarction treatment support system. FIG. [Figure 11] 4 is a schematic diagram for explaining a process of transmitting first information and / or second information to an X-ray imaging apparatus. FIG. [Figure 12] FIG. 11 is a flow diagram showing a process of transmitting first information and / or second information. [Figure 13] FIG. 11 is a flow diagram showing a process of deleting the first information. [Figure 14] FIG. 11 is a flow diagram showing a process of transmitting second information and a CT image or an MRI image. [Figure 15] FIG. 1 is a block diagram showing a configuration of an angiography apparatus. [Figure 16] FIG. 1 is a diagram illustrating an example of an angiography apparatus. [Figure 17] FIG. 11 is a diagram for explaining generation of a superimposed image. [Figure 18] FIG. 13 is a diagram for explaining reconstruction of blood vessel image data. [Figure 19] 4 is a flowchart showing the operation of the angiography apparatus. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0014] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings.

[0015] The configuration of a cerebral infarction treatment support system 100 according to one embodiment will be described with reference to FIG.

[0016] The cerebral infarction treatment support system 100 is a system that supports the diagnosis and treatment of acute cerebral infarction patients. The cerebral infarction treatment support system 100 is installed in a medical facility such as a hospital. The cerebral infarction treatment support system 100 is configured to provide doctors and the like with information useful for diagnosis and treatment when diagnosing and treating acute cerebral infarction patients transported to the facility. The cerebral infarction treatment support system 100 can provide doctors and the like with support information different from medical images, separate from medical images (X-ray images, CT images, MRI images, etc.) used in the diagnosis and treatment of acute cerebral infarction patients.

[0017] The cerebral infarction treatment support system 100 includes at least a gene detection device 10 , an image control unit 20 , and a display unit 30 .

[0018] The detection device 10 is configured to measure a biological sample 2 collected from a patient 1 and generate first information 41 indicating whether or not the biological sample 2 contains a susceptibility gene for cerebral infarction. The detection device 10 is installed, for example, in an examination room of a medical facility such as a hospital.

[0019] The biological sample 2 is a liquid collected from the patient 1 and contains at least the genomic DNA of the patient 1. The biological sample 2 includes, for example, specimens such as blood and saliva collected from the patient 1. The blood includes any of whole blood, plasma, and serum. The specimen may be tissues such as hair, nails, skin, and mucous membranes, or cells. In addition to the specimen, the biological sample 2 may include components used in the measurement of the detection device 10. The biological sample 2 may include, for example, a dissolving solution for eluting genes from the specimen, a reaction solution for amplifying genes, and the like. The reaction solution is designed to specifically react with susceptibility genes related to cerebral infarction, which is the detection target. In this specification, the biological sample is a concept that includes not only the specimen itself collected from the patient 1, but also a prepared sample prepared from the specimen and other components.

[0020] A susceptibility gene for cerebral infarction is significantly correlated with the possibility of developing a particular type of cerebral infarction. In other words, the presence of a susceptibility gene for cerebral infarction in the biological sample 2 indicates that the possibility of developing the type of cerebral infarction associated with the susceptibility gene is significantly higher or lower than when the susceptibility gene is not present. The susceptibility gene for cerebral infarction can be a specific genetic mutation or gene polymorphism. The first information 41 indicates whether or not such a genetic mutation or gene polymorphism is present in the DNA in the biological sample 2.

[0021] The first information 41 is information that can determine at least whether or not a susceptibility gene for cerebral infarction is present. The first information 41 can be, for example, binary information indicating either "there is a susceptibility gene for cerebral infarction (positive)" or "there is no susceptibility gene for cerebral infarction (negative)." The first information 41 can be information indicating whether there are two mutations or genetic polymorphisms that are susceptibility genes (mutant homozygous), one (mutant / wild type heterozygous), or none (wild type homozygous).

[0022] In the cerebral infarction treatment support system 100, second information 42 related to the diagnosis or treatment of cerebral infarction can be generated based on first information 41 on whether or not a susceptibility gene for cerebral infarction exists. The second information 42 can be, for example, information indicating a type of cerebral infarction significantly associated with a susceptibility gene for cerebral infarction. In addition to this, for example, a patient having a susceptibility gene may exhibit a characteristic (trait) that makes the patient more likely to develop cerebral infarction. The characteristic that makes the patient more likely to develop cerebral infarction is, for example, a tendency for blood vessels in the brain to be thin or a tendency for blood vessel walls to be weak. The second information 42 is secondary information generated by taking into account other medical and scientific findings, with the first information 41 on whether or not a susceptibility gene for cerebral infarction exists as primary information. The second information 42 does not need to be generated by the detection device 10. The second information 42 can be generated by, for example, a computer or a server that can acquire the first information 41 from the detection device 10 via a network.

[0023] The image control unit 20 acquires at least one of the first information 41 generated by the detection device 10 and the second information 42 related to the susceptibility gene generated based on the first information 41. The image control unit 20 controls the display unit 30 to display at least one of the acquired first information 41 and second information 42. The image control unit 20 includes, for example, a computer configured to be able to communicate with the detection device 10 and the display unit 30.

[0024] Specifically, the image control unit 20 includes a receiving unit 21 and a video output unit 22. The receiving unit 21 receives at least one of the first information 41 generated by the detection device 10 and the second information 42 related to the susceptibility gene generated based on the first information 41. The receiving unit 21 can directly communicate with the detection device 10, for example, by wire or wirelessly. The receiving unit 21 can communicate with the detection device 10, for example, via a network. The receiving unit 21 does not need to receive information from the detection device 10, and it is sufficient that the receiving unit 21 can access, via the network, a device that stores the first information 41 generated by the detection device 10 and the second information 42 generated based on the first information 41.

[0025] The video output unit 22 outputs at least one of the received first information 41 and second information 42 to the display unit 30. The video output unit 22 is electrically connected to the display unit 30 by wire or wirelessly. FIG. 1 shows an example in which the image control unit 20 is installed outside the reading room 901 or the catheter room 902. In the example of FIG. 1, the image control unit 20 delivers at least one of the first information 41 and the second information 42 to the display unit 30 installed in the reading room 901 or the catheter room 902.

[0026] The display unit 30 is a monitor that displays information. The display unit 30 is disposed in at least one of a catheter room 902 in which a blood vessel X-ray imaging device is disposed and an image reading room 901 in which an image viewing terminal for radiological diagnostic images or MRI images is disposed. The image control unit 20 outputs the received information (first information 41 and / or second information 42) to the display unit 30. The display unit 30 displays the information (first information 41 and / or second information 42) output from the image control unit 20.

[0027] In the cerebral infarction treatment support system 100, information output from the image control unit 20 (at least one of the first information 41 and the second information 42) is displayed on the display unit 30 at least during treatment or diagnosis of the patient 1.

[0028] For patients with acute cerebral infarction, diagnostic CT images or MRI images are taken by a CT device or MRI device in the hospital, and a diagnosis is made in an image reading room 901 in the hospital. In the cerebral infarction treatment support system 100, for example, when diagnosing a patient 1, information received by the image control unit 20 is output to a display unit 30 installed in the image reading room 901. The image reading room 901 is a room in which an image viewing terminal (PC) for diagnostic images such as a radiation diagnostic device (X-ray device, CT device, etc.) or an MRI is installed.

[0029] After diagnosis, in the stage of treating a cerebral infarction patient, for example, catheter treatment is performed on the infarcted site in the cerebral blood vessel. In the cerebral infarction treatment support system 100, for example, during catheter treatment of a patient 1, information received by the image control unit 20 is output to a display unit 30 installed in a catheter room 902. The catheter room 902 is a room in which an angiography device used during catheter treatment is installed.

[0030] In this way, the display unit 30 is disposed in at least one of the catheter lab 902 and the image reading room 901 in the hospital. The cerebral infarction treatment support system 100 may include other display units in addition to the display units 30 in the catheter lab 902 and the image reading room 901. Such a display unit 30 may be, for example, a display unit of a portable information terminal such as a tablet terminal carried by a doctor or the like.

[0031] (Detection device) The detection device 10 detects a susceptibility gene (detection target gene) for cerebral infarction from a biological sample 2. Detecting a susceptibility gene means detecting a specific base sequence in genomic DNA contained in the biological sample 2. The detection device 10 generates, as a detection result, first information 41 indicating whether or not the biological sample 2 contains a susceptibility gene for cerebral infarction.

[0032] The number of susceptibility genes detected by the detection device 10 is not limited to one (one type). When the presence or absence of susceptibility genes related to multiple types of cerebral infarction significantly correlates with the possibility of developing any one of the types of cerebral infarction, the first information 41 may represent the presence or absence of each of the multiple types of susceptibility genes.

[0033] The detection device 10, for example, amplifies a gene to be detected in the biological sample 2. The detection device 10, for example, binds the gene to be detected with a labeling substance. The detection device 10 detects a susceptibility gene related to cerebral infarction, for example, by detecting the labeling substance bound to the gene to be detected. The labeling substance is not particularly limited as long as it generates a signal detectable by the detection device 10, and includes, for example, a fluorescent substance (fluorescent label). In this case, the detection device 10 irradiates the biological sample 2 with excitation light and detects the fluorescence generated from the labeling substance.

[0034] 2, the detection device 10 is a gene amplification detection device that amplifies and detects a target gene by using a PCR (Polymerase Chain Reaction) method. The detection device 10 includes a container mounting unit 11, a detection unit 12, a temperature adjustment unit 13, and a data processing unit 14.

[0035] The container placement section 11 is configured so that a sample container 3 containing a biological sample 2 can be placed thereon. The sample container 3 is a light-transmitting reaction container, and may be a so-called PCR tube, a well plate, or the like.

[0036] The temperature adjustment unit 13 is configured to heat and / or cool the sample container 3 placed on the container placement unit 11, and adjust the temperature of the biological sample 2. The temperature adjustment unit 13 performs a thermal cycle process that periodically raises and lowers the temperature of the biological sample 2. By the thermal cycle process, the detection target gene (susceptibility gene for cerebral infarction) in the biological sample 2 is amplified.

[0037] The detection unit 12 includes a light source 12a and a photodetector 12b. The light source 12a includes, for example, an LED (light emitting diode) element, and generates excitation light for a fluorescent probe contained in the biological sample 2. The light source 12a irradiates the biological sample 2 in the sample container 3 placed on the container mounting unit 11 with the excitation light. The fluorescent probe contained in the biological sample 2 is excited by the irradiation of the excitation light and generates fluorescence. The photodetector 12b is configured to detect the fluorescence generated from the fluorescent probe contained in the biological sample 2. The photodetector 12b outputs a detection signal according to the intensity of the fluorescence generated from the biological sample 2. The photodetector 12b includes, for example, a photomultiplier tube (PMT) or a photodiode.

[0038] In the configuration example of FIG. 2, the detection device 10 is configured to perform a gene amplification process on a biological sample 2 containing a specimen 2a including blood or saliva collected from a patient 1 and a reaction solution 2c including a component that suppresses the influence of inhibitory substances in the specimen 2a. In other words, the detection device 10 is a direct PCR device that performs a PCR process on a biological sample 2 prepared without performing a purification process for purifying DNA from the specimen 2a. "Direct PCR" means that a PCR process is performed without going through a DNA purification process. The reaction solution 2c including a component that suppresses the influence of inhibitory substances includes a PCR enzyme, a fluorescent probe, a primer, and a component that suppresses the influence of inhibitory substances in the specimen 2a. As the component that suppresses the influence of inhibitory substances, for example, Ampdirect (registered trademark) buffer manufactured by Shimadzu Corporation is preferably used.

[0039] The detection device 10 is also configured to perform a real-time PCR method in which a labeling process is performed using a labeling substance during the gene amplification process. That is, the detection device 10 does not perform a labeling process on the amplified product after gene amplification by PCR, but specifically binds a fluorescent probe to a detection target gene (a susceptibility gene for cerebral infarction) during the gene amplification process by PCR.

[0040] In the configuration example of FIG. 2, first, a specimen 2a collected from a patient 1 is mixed with a cell lysis solution 2b. The mixture of the specimen 2a and the cell lysis solution 2b is mixed with a reaction solution 2c in a sample container 3. The reaction solution 2c contains a PCR enzyme, a fluorescent probe, a primer, and a component that suppresses the effects of inhibitory substances in the specimen 2a. In this way, a biological sample 2 is prepared. The component that suppresses the effects of inhibitory substances allows PCR processing to be performed without a DNA (deoxyribonucleic acid) purification process. The detection unit 12 detects fluorescence indicating the presence of the target gene during gene amplification by real-time PCR processing, and outputs a detection signal according to the fluorescence intensity to a data processing unit 14.

[0041] The data processing unit 14 is configured by a computer including a processor 14a such as a CPU (Central Processing Unit), a storage unit 14b storing a program 15 for gene analysis, and a communication unit 14c. The storage unit 14b includes a volatile and / or non-volatile storage device. The communication unit 14c includes a communication interface that can be connected to a network of a medical facility such as a hospital.

[0042] The processor 14a acquires a detection signal output from the detector 12. The processor 14a executes the program 15 stored in the memory 14b to analyze the detection signal. The processor 14a generates, through the analysis, first information 41 indicating whether or not the biological sample 2 has a susceptibility gene for cerebral infarction. The processor 14a causes the communication unit 14c to transmit the first information 41 to the server 50 via the network. The first information 41 may be transmitted directly to the image controller 20.

[0043] The biological sample 2 collected from the patient 1 is assigned patient information 45. The patient information 45 includes unique identification information for identifying the patient 1. The detection device 10 assigns, for example, the patient information 45 of the patient 1 from whom the biological sample 2 was collected to the first information 41.

[0044] 2 shows an example in which a prepared sample in which the specimen 2a, the cell lysis solution 2b, and the reaction solution 2c are mixed is supplied to the detection device 10 as the biological sample 2, but instead, for example, a biological sample 2 containing only the specimen 2a may be supplied to the detection device 10. In this case, the detection device 10 may be configured to include a mechanism for dispensing the cell lysis solution 2b and the reaction solution 2c into the sample container 3 containing the biological sample 2, and to prepare a sample for measurement within the detection device 10.

[0045] The susceptibility gene for cerebral infarction may be a single nucleotide polymorphism (SNP) in the base sequence of a specific gene. The detection method of SNP may be, for example, RFLP (restriction fragment length polymorphism), PCR-SSCP (single-stranded DNA conformation polymorphism analysis), ASO (allele specific oligonucleotide) hybridization, sequencing, ARMS (amplification refracting mutation system), denaturing gradient gel electrophoresis, RNAseA cleavage, DOL (dye-labeled oligonucleotide ligation), TaqMan PCR, primer extension, or invader. The detection device 10 may be a device capable of implementing any of the above detection methods, in addition to the configuration example shown in FIG. 2.

[0046] (Susceptibility genes for cerebral infarction) Susceptibility genes for cerebral infarction include, for example, the RNF213p.R4810K gene polymorphism.

[0047] RNF213 (Ring finger protein 213) (GenBank accession number NM_001256071.1) is located in the human chromosome region 17q25.3.

[0048] The RNF213 p.R4810K gene polymorphism is a single nucleotide polymorphism (SNP) of 73097 G>A in the nucleotide sequence represented by SEQ ID NO: 2. The detection device 10 detects the SNP of 73097 G>A in the biological sample 2.

[0049] Sequence number 2 is a partial nucleotide sequence of human chromosome 17 DNA containing the mysterin gene and genes in its surrounding region [FLJ3520, NPTX1, CARD14, and Raptor (KIAA1303)], and corresponds to nucleotides 43560001 to 43795000 of Contig #NT010783.15 registered in NCBI.

[0050] In the nucleotide sequence represented by SEQ ID NO:2, in addition to the SNP at position 73097 (73097 G>A), which is G or A, there may also be a SNP at position 4766 (4766 T>C), which is T or C, a SNP at position 120764 (120764 G>A), which is G or A, a SNP at position 152917 (152917 G>A), which is G or A, and a SNP at position 232102 (232102 G>A), which is G or A.

[0051] In this specification, the position of an SNP is described based on the position of the nucleotide in the nucleotide sequence shown in SEQ ID NO: 2. For example, "SNP at position 73097" means an SNP at the nucleotide at position 73097 in the nucleotide sequence shown in SEQ ID NO: 2. When describing "73097 G>A", the major allele base (G in this case) is described before the ">" symbol, and the minor allele base (A in this case) is described after it.

[0052] In addition, nucleotide sequences in this specification are described as DNA sequences unless otherwise specified, but when the polynucleotide is RNA (ribonucleic acid), thymine (T) should be read as uracil (U) as appropriate. A polynucleotide may contain any additional sequence in addition to a continuous partial sequence of the nucleotide sequence shown in SEQ ID NO: 2 or its complementary sequence.

[0053] Research by the present inventors has revealed that the RNF213 p.R4810K polymorphism increases the risk of ischemic stroke (i.e., atherothrombotic cerebral infarction) due to aortic atherosclerosis. The present inventors have filed a patent application based on this finding. The patent application numbers of the present inventors are Japanese Patent Application No. 2018-233549 and PCT / JP2018 / 045915, and the present specification incorporates the entire disclosure contents of these applications by reference.

[0054] 3(A) to 3(F) show examples of detection results of the RNF213 p.R4810K genetic polymorphism using the detection device 10. In each of the graphs in Fig. 3(A) to 3(F), the vertical axis indicates the signal intensity (fluorescence intensity) of the detection signal from the detection device 10, and the horizontal axis indicates the number of cycles of the PCR process in the detection device 10.

[0055] FIG. 3(A) shows the detection result of the wild-type positive control of the RNF213 gene. FIG. 3(B) shows the detection result of the mutant positive control of the RNF213 gene. The wild-type means a base sequence in which the p.R4810K gene polymorphism does not exist, and the mutant means a base sequence in which the p.R4810K gene polymorphism exists. The positive control is a synthesis of DNA having each of the wild-type and mutant sequences. FIG. 3(C) shows the detection result of a heterozygote positive control in which one allele of RNF213 is wild-type and the other is mutant. FIG. 3(D) shows the detection result using blood collected from a subject. FIG. 3(E) shows the detection result using saliva collected from a subject. FIG. 3(F) shows the detection result of a negative control for verifying the determination result of the detection device 10. The negative control is a sample that does not contain either the wild-type or mutant type of the RNF213 gene.

[0056] In FIG. 3(A), the intensity of the fluorescent signal (referred to as wild-type signal 16) generated from the fluorescent probe that specifically binds to the wild-type of the RNF213 gene increases, while the intensity of the fluorescent signal (referred to as mutant signal 17) generated from the fluorescent probe that specifically binds to the mutation of the RNF213 gene does not change. In FIG. 3(B), the intensity of the wild-type signal 16 does not change, and the intensity of the mutant signal 17 increases. In FIG. 3(C), the intensities of both the wild-type signal 16 and the mutant signal 17 increase. For this reason, it is possible to determine the presence or absence of the RNF213 p.R4810K gene polymorphism based on the change in intensity of the mutant signal 17 from the detection results of the detection device 10.

[0057] Figures 3(D) and 3(E) confirmed that the blood and saliva samples actually collected from the subjects also showed changes in signal intensity similar to those of the positive control. Figure 3(F) confirmed that there was no nonspecific amplification, and that specific amplification and labeling of the target gene was achieved.

[0058] From the above, the data processing unit 14 shown in FIG. 2 discriminates the presence or absence of a susceptibility gene for cerebral infarction (RNF213 p.R4810K gene polymorphism) based on the intensity change of the mutant signal 17. The data processing unit 14 creates first information 41 according to the discrimination result. That is, the data processing unit 14 generates the first information 41 indicating the presence of a susceptibility gene for cerebral infarction when the intensity of a signal (mutant signal 17) derived from a marker substance for a susceptibility gene for cerebral infarction increases in the detection result. The data processing unit 14 generates the first information 41 indicating the absence of a susceptibility gene for cerebral infarction when the intensity of a signal (mutant signal 17) derived from a marker substance for a susceptibility gene for cerebral infarction does not increase in the detection result.

[0059] As a criterion for determining whether or not a susceptibility gene is present in the detection result, for example, a threshold value is set for the signal intensity. The data processing unit 14 obtains, for example, a difference value between the signal intensity at the start of the PCR process and the signal intensity at the end of the PCR process, and determines that a susceptibility gene is present when the obtained difference value exceeds the threshold. Alternatively, it may be simply determined that a susceptibility gene is present when the signal intensity of the mutant signal 17 exceeds the threshold.

[0060] The susceptibility gene for cerebral infarction may be other than the RNF213 p.R4810K gene polymorphism. Recent genetic research suggests a correlation between cardiogenic cerebral infarction and related genes PITX2 (human chromosome region 4q25) and ZFHX3 (human chromosome region 16q22). A correlation between lacunar infarction and related genes such as ALDH2 (human chromosome region 12q24) has been suggested. The susceptibility gene for cerebral infarction may include one or more of these genes. The susceptibility gene for cerebral infarction may be any gene that shows a significant correlation with a specific cerebral infarction, and is not limited to the above-mentioned ones.

[0061] (Second information) Next, the second information 42 will be described. In the example shown in Fig. 4, the second information 42 includes at least one of information 42a on the type of cerebral infarction, information 42b on the cerebral blood vessels of the patient 1, and information 42c (hereinafter referred to as "device information 42c") indicating a treatment device whose use is recommended or not recommended in cerebral infarction catheter treatment of the patient 1. The second information 42 is generated, for example, in the form of a message (text) for the user.

[0062] The information 42a on the type of cerebral infarction is information indicating the type of cerebral infarction that is significantly correlated with the susceptibility gene whose presence or absence is detected by the first information 41. The types of cerebral infarction are classified into three types: cardiogenic cerebral embolism, lacunar infarction, and atherothrombotic cerebral infarction. The presence of a susceptibility gene indicates, for example, that the likelihood of developing any type of cerebral infarction is significantly high or low. The information 42a on the type of cerebral infarction can be a message indicating the type of cerebral infarction that is significantly high or low in likelihood of developing.

[0063] The information 42b on the cerebral blood vessels of the patient 1 is information on the form or properties of the cerebral blood vessels of the patient 1 that is inferred based on the presence or absence of a susceptibility gene. The information 42b on the cerebral blood vessels of the patient 1 may be, for example, a message indicating that the cerebral blood vessels tend to be thick or thin when the patient has a susceptibility gene. The information 42b on the cerebral blood vessels of the patient 1 may be, for example, a message indicating that the cerebral blood vessels tend to be strong (resistant to injury) or weak (easily injured) when the patient has a susceptibility gene.

[0064] The device information 42c is information that indicates the type or shape of a treatment device that is an option for catheter treatment.

[0065] Therapeutic devices used in catheter treatment of cerebral infarction include a thrombus retrieval device 5a, a thrombus suction device 5b, and a percutaneous transluminal angioplasty device 5c, all of which are shown in Fig. 5. The thrombus retrieval device 5a has a coiled wire for entangling and retrieving a thrombus. The thrombus suction device 5b is hollow tubular and is configured to be able to remove a thrombus by suctioning it into the inside. The percutaneous transluminal angioplasty device 5c includes a balloon catheter and a stent.

[0066] The device information 42c may be, for example, a message indicating a therapeutic device whose use is recommended or not recommended, among the thrombectomy device 5a, the thrombectomy device 5b, and the percutaneous transluminal angioplasty device 5c.

[0067] For example, the presence of the RNF213 p.R4810K gene polymorphism significantly increases the likelihood of developing atherothrombotic cerebral infarction. In addition, in individuals with this gene polymorphism, the relatively large blood vessels in the brain, which are the site of infarction due to atherothrombotic cerebral infarction, tend to be thinner than the same site in individuals without this gene polymorphism. Furthermore, since the relatively large blood vessels in the brain tend to be thinner than normal, the use of a thrombus retrieval device that is likely to come into contact with blood vessels may cause re-occlusion due to endothelial damage in the occluded blood vessels.

[0068] Therefore, as an example, as shown in FIG. 6, when the first information 41 indicates the presence of the RNF213 p.R4810K gene polymorphism, the information 42a on the type of cerebral infarction includes a message indicating that the type of cerebral infarction suffered by the patient 1 from whom the biological sample 2 was collected is "highly likely to be atherothrombotic cerebral infarction." The information 42b on the cerebral blood vessels of the patient 1 includes a message indicating that the cerebral blood vessels of the patient 1 from whom the biological sample 2 was collected "tend to be thin." The device information 42c includes a message indicating that "use of the thrombus retrieval device 5a is not recommended" and / or a message indicating that "use of the thrombus aspiration device 5b or the percutaneous transluminal angioplasty device 5c is recommended." The device information 42c may include a message indicating that "use of a treatment device with a smaller diameter than usual is recommended."

[0069] 2, the cerebral infarction treatment support system 100 includes a server 50 that is communicably connected to the detection device 10 and the image control unit 20 and stores the first information 41. The server 50 is configured to generate the second information 42 based on the first information 41, as shown in FIG.

[0070] As described above, the server 50 has a second information generation table 51 for generating the second information 42 according to the content of the first information 41 (presence / absence of a susceptibility gene). The second information generation table 51 is a data table in which the presence or absence of a specific susceptibility gene and the content of the second information 42 to be generated corresponding to the presence or absence of the susceptibility gene are recorded in association with each other. When the server 50 acquires the first information 41 from the detection device 10, the server 50 generates the second information 42 by referring to the second information 42 corresponding to the content of the first information 41 from the second information generation table 51. The second information 42 is associated with the first information 41 or the patient information 45 assigned to the first information 41. The patient information 45 assigned to the first information 41 may also be assigned to the second information 42.

[0071] The second information 42 may be generated by a server 50 in the hospital or may be generated by a cloud server via the Internet. The detection device 10 may generate the second information 42 together with the first information 41. The server 50 includes, for example, at least one of a radiology information system server and a medical image management system server connected to a network in the hospital. Here, the radiology information system server is called a RIS (Radiology Information Systems) server 52 (see FIG. 7), and is a server that executes processing of a system that mainly performs examinations using radiation equipment and manages examination results. The medical image management system server is a server that collects and records medical image data, and is also called a DICOM server 53 (see FIG. 7) because it handles medical image data that conforms to the DICOM standard, which is a standard.

[0072] The image control unit 20 (see FIG. 1 ) is configured to receive at least the second information 42 from the server 50, for example. The image control unit 20 outputs at least the received second information 42 to the display unit 30 for display. The image control unit 20 may receive both the first information 41 and the second information 42 and display them on the display unit 30. The image control unit 20 may display only the first information 41 on the display unit 30, in which case the cerebral infarction treatment support system 100 does not need to generate the second information 42.

[0073] (Example of the configuration of a cerebral infarction treatment support system) 7 shows a more specific example of the configuration of the cerebral infarction treatment support system 100. The cerebral infarction treatment support system 100 can be configured as a part or the whole of an intra-hospital network.

[0074] Radiation devices such as a CT device 101 and an MRI device 102 and a detection device 10 are connected to the intra-hospital network. Various portable terminals 103 such as a tablet type information terminal, and various servers such as a RIS server 52 and a DICOM server 53 are connected to the intra-hospital network. In addition, a blood vessel X-ray imaging device 70 installed in a catheterization room 902 and an image viewing terminal 80 installed in an image reading room 901 are connected to the intra-hospital network.

[0075] In the catheter room 902, a blood vessel X-ray imaging device 70, a catheter device 104, etc. are installed. A treatment device 5 to be used during treatment is prepared. The blood vessel X-ray imaging device 70 is an angiography device that performs fluoroscopic imaging of blood vessels. The blood vessel X-ray imaging device 70 detects X-rays irradiated from an X-ray source with an X-ray detector and creates an image. The blood vessel X-ray imaging device 70 includes a first control device 71 that performs control processing of the device, and a first display unit 72 that displays the captured X-ray image. The blood vessel X-ray imaging device 70 performs fluoroscopic imaging of the catheter introduced into the blood vessel during catheter treatment in a moving image format, and displays the image on the first display unit 72. The blood vessel X-ray imaging device 70 will be described in detail later.

[0076] The image viewing terminal 80 installed in the image reading room 901 is, for example, a PC (personal computer), and includes a second control device 81 constituting the PC main body, and a second display unit 82. In the image reading room 901, a doctor or the like uses the image viewing terminal 80 to view medical images of the patient 1, identify the site of the thrombus in the cerebral infarction patient 1, and determine the diagnosis and treatment plan. The medical images include CT images taken by a CT device 101 and MRI images taken by an MRI device.

[0077] 7, the image control unit 20 includes a first control device 71 provided in the angiographic X-ray apparatus 70 installed in the catheter room 902. The first control device 71 includes a receiving unit 21 and a video output unit 22. The display unit 30 includes a first display unit 72 installed in the catheter room 902 and displaying an X-ray image 73 of the angiographic X-ray apparatus 70.

[0078] Specifically, the first control device 71 is configured to output at least one of the received first information 41 and second information 42 and an X-ray image 73 of the patient 1 taken by the angiographic X-ray device 70 to the first display unit 72 during catheter treatment of the patient 1 in the catheter laboratory 902. As a result, during treatment of the patient 1 in the catheter laboratory 902, the information received by the image control unit 20 (at least one of the first information 41 and second information 42) is displayed.

[0079] 7, the image control unit 20 includes a second control device 81 provided in the image viewing terminal 80 installed in the reading room 901. The second control device 81 includes a receiving unit 21 and a video output unit 22. The display unit 30 includes a second display unit 82 installed in the reading room 901 and performing screen display of the image viewing terminal 80.

[0080] Specifically, the second control device 81 is configured to receive at least one of the first information 41 and the second information 42 and the CT image 6 or the MRI image 7 of the patient 1 during diagnosis of the patient 1 in the reading room 901, and output them to the second display unit 82. As a result, during diagnosis of the patient 1 in the reading room 901, the information received by the image control unit 20 (at least one of the first information 41 and the second information 42) is displayed.

[0081] As described above, the first information 41 and the second information 42 are either assigned with the patient information 45 or are recorded in the server 50 (RIS server 52 or DICOM server 53) in association with the patient information 45. Furthermore, the patient information 45 is assigned to the X-ray image 73, CT image 6, and MRI image 7 taken by the angiographic X-ray apparatus 70 at the time of capture. These images and the first information 41 and second information 42 can be identified as having been obtained from the same patient 1 based on the patient information 45.

[0082] Therefore, in the above configuration example, the image control unit 20 receives an image of the patient 1 to which the patient information 45 has been assigned, and outputs the image having the same patient information 45 and at least one of the first information 41 and the second information 42 to the display unit 30. The image of the patient 1 includes any one of the X-ray image 73 obtained by the angiographic X-ray device 70, the CT image 6, and the MRI image 7, and may also include other medical images.

[0083] The cerebral infarction treatment support system 100 may be configured to provide at least one of the first information 41 and the second information 42 to a doctor or the like after treatment of the cerebral infarction patient 1, even during postoperative evaluation or confirmation of the progress of treatment.

[0084] (Patient treatment flow) Next, the flow of treatment for the acute cerebral infarction patient 1 will be briefly described with reference to FIG.

[0085] First, Patient 1, who is suspected to have suffered a cerebral infarction, is brought to the hospital as an emergency patient.

[0086] After the patient is carried in, patient information 45 and triage information are input to the hospital network system. The triage information is information indicating the priority of the treatment order determined based on the severity of the patient 1. In addition, a specimen 2a is obtained from the patient 1.

[0087] In an imaging room, a CT image 6 or an MRI image 7 of a patient 1 is taken by a CT device 101 or an MRI device 102. In parallel with the imaging of the patient 1, a biological sample 2 is prepared from a specimen 2a and supplied to a detection device 10. In parallel with the imaging of the patient 1, the cerebral infarction treatment support system 100 detects susceptibility genes by the detection device 10.

[0088] Next, in the image reading room 901, a diagnosis is made on the patient 1 based on the captured CT image 6 or MRI image 7. The image control unit 20 displays at least one of the first information 41 and the second information 42 together with an image of the patient 1 based on the patient information 45 (see FIG. 6). Based on the provided information, a doctor or the like diagnoses that the patient 1 has developed cerebral infarction, identifies the site of the thrombus, and determines a treatment plan.

[0089] For example, a first procedure is performed according to the treatment plan. The first procedure is administration of a thrombolytic agent to the patient 1. If the administration of the thrombolytic agent does not sufficiently improve the blood flow in the cerebral blood vessels, a second procedure is performed as necessary. The second procedure is catheter treatment.

[0090] During catheter treatment, the image control unit 20 displays at least one of the first information 41 and the second information 42 together with an X-ray image 73 (see FIG. 7) of the patient 1 based on the patient information 45. The doctor in charge of treatment selects a treatment device 5 with reference to the provided information, and performs catheter treatment while referring to the X-ray image 73 inside the blood vessel.

[0091] (Operation of cerebral infarction treatment support system) Next, the operation of the cerebral infarction treatment support system 100 will be described with reference to Fig. 9. The cerebral infarction treatment support method of this embodiment is carried out by the cerebral infarction treatment support system 100. Note that Fig. 2 is to be referred to for the detection device 10, and Figs. 4 and 6 are to be referred to for the first information 41, the second information 42, and the patient information 45.

[0092] In step 91, the detection device 10 measures the biological sample 2 collected from the patient 1, and generates first information 41 on whether or not the biological sample 2 contains a susceptibility gene for cerebral infarction.

[0093] In step 92, the detection device 10 assigns the patient information 45 of the patient 1 to the first information 41 generated from the biological sample 2 collected from the patient 1 who has been admitted as an emergency patient.

[0094] In step 93, the second information 42 may be generated based on the first information 41. If the second information 42 is not to be displayed, step 93 is unnecessary.

[0095] In step 94, the receiving unit 21 (see FIGS. 1 and 7) of the image control unit 20 receives at least one of the first information 41 and the second information 42.

[0096] In step 95, the video output unit 22 (see FIGS. 1 and 7) of the image control unit 20 outputs at least one of the first information 41 and the second information 42 received by the image control unit 20 to the display unit 30 for display. The image control unit 20 receives the first information 41 of the patient 1 from whom the biological sample 2 was collected based on the patient information 45, and outputs it to the display unit 30 (see FIGS. 1 and 7).

[0097] The first information 41 and / or the second information 42 may be displayed only at the time of treatment or diagnosis of the patient 1. In particular, treatment of the acute cerebral infarction patient 1 needs to be performed within a short period of time. Therefore, if it takes time to detect a susceptibility gene, generation of the first information 41 may not be completed at the time of diagnosis of the patient 1. Even in this case, in this embodiment, the received information is displayed on the display unit 30 together with the patient information 45 at least until the time of treatment of the patient 1. The treating doctor can select the treatment device 5 with reference to the first information 41 and / or the second information 42.

[0098] (Another example of the configuration of the cerebral infarction support system) Next, a cerebral infarction treatment support system 200 according to another configuration example will be described with reference to Figures 10 and 11. The cerebral infarction treatment support system 200 executes the cerebral infarction treatment support method of this embodiment.

[0099] 10, the cerebral infarction treatment assistance system 200 includes a detection device 210, a server 250, and a modality 105. The server 250 is an example of the "management unit" in the claims.

[0100] The server 250 includes a RIS server 252, a DICOM server 253, and a hospital information system server connected to the network in the hospital. Here, the hospital information system server is called a HIS (Hospital Information Systems) server 254, and includes, for example, an automatic reception system, an electronic medical record management system, a medical accounting system, a medical appointment system, a pharmacy management system, and the like. The HIS server 254 is configured to store patient information 245. Note that the RIS server 252 and the DICOM server 253 have the same configuration as the RIS server 52 (see FIG. 7) and the DICOM server 53 (see FIG. 7), respectively, and therefore detailed description thereof will be omitted.

[0101] Modality 105 includes angiography X-ray apparatus 270 (see FIG. 11), image viewing terminal 80 (see FIG. 11), CT apparatus 101 (see FIG. 7), and MRI apparatus 102 (see FIG. 7). In this specification, "modality" refers collectively to these medical imaging devices. Since angiography X-ray apparatus 270 has a similar configuration to angiography X-ray apparatus 70, a detailed description thereof will be omitted. Furthermore, angiography X-ray apparatus 270 is an example of "apparatus used in treating a patient" in the claims.

[0102] (Gene-related information) The detection device 210 measures a biological sample 2 collected from a patient 1, and generates gene-related information 240 related to susceptibility genes for cerebral infarction. The gene-related information 240 includes first information 241 indicating whether the biological sample 2 has a susceptibility gene for cerebral infarction or not, and second information 242 related to the susceptibility gene generated based on the first information 241.

[0103] (First and second information) The server 250 is configured to generate second information 242 related to susceptibility genes based on the first information 241 included in the gene-related information 240 generated by the detection device 210. The first information 241 is similar to the first information 41 (see FIG. 4). That is, the first information 241 includes patient information 245 and information on the presence / absence of gene polymorphism. The patient information 245 is similar to the patient information 45 (see FIG. 4) and includes identification information 245a. The identification information 245a is unique information that can identify the patient 1. The identification information 245a includes, for example, a patient identification number. The second information 242 is similar to the second information 42 (see FIG. 4). That is, the second information 242 includes at least one of information 42a related to the type of cerebral infarction, information 42b related to the cerebral blood vessels of the patient 1, and information 42c indicating a treatment device whose use is recommended or not recommended in the cerebral infarction catheter treatment of the patient 1.

[0104] 10, the HIS server 254 transmits an examination request 201 to the detection device 210. When transmitting the examination request 201, the HIS server 254 also transmits identification information 245a of the patient 1 to be examined.

[0105] The detecting device 210 that receives the inspection request 201 performs the inspection and generates first information 241. The detecting device 210 also links the generated first information 241 to the identification information 245a transmitted together with the inspection request 201. The detecting device 210 transmits the first information 241 linked with the identification information 245a to the HIS server 254.

[0106] The HIS server 254 manages the first information 241 transmitted from the detection device 210. Note that managing the first information 241 includes storing the first information 241 in the HIS server 254. Also, managing the first information 241 includes transmitting the first information 241 to the blood vessel X-ray imaging device 270 and the like.

[0107] The server 250 is configured to generate second information 242 related to susceptibility genes based on first information 241 included in the gene-related information 240 generated by the detection device 210.

[0108] In this embodiment, the server 250 is configured to store the identification information 245a of the patient 1. The server 250 is communicably connected to the detection device 210. The server 250 is configured to associate the set identification information 245a of the patient 1 with the stored identification information 245a of the patient 1, and to associate and manage at least one of the stored identification information 245a of the patient 1 or the patient information 245 of the patient 1 related to the identification information 245a of the patient 1 with the gene-related information 240. In this embodiment, the process of setting the identification information 245a of the patient 1 in the gene-related information 240 is executed by the detection device 210 that generates the gene-related information 240.

[0109] In this embodiment, the server 250 is configured to associate at least one of the first information 241 and the second information 242 with identification information 245a that identifies the patient 1 (see FIG. 1 ), thereby associating and managing at least one of the first information 241 and the second information 242 with patient information 245 of the patient 1. In this embodiment, the HIS server 254 is configured to associate the second information 242 with the patient information 245. In addition, the HIS server 254 is configured to store the second information 242 in a state of being associated with the patient information 245.

[0110] Moreover, the HIS server 254 transmits an imaging request 202 for the patient 1 to the RIS server 252. The RIS server 252 transmits the imaging request 202 to the modality 105 based on the received imaging request 202. Specifically, when a request to acquire a CT image 6 for the patient 1 is transmitted, the RIS server 252 transmits the imaging request 202 to the CT device 101. Moreover, when a request to acquire an MRI image 7 for the patient 1 is transmitted, the RIS server 252 transmits the imaging request 202 to the MRI device 102. Here, the imaging request 202 may include patient information 245.

[0111] The modality 105 (here, the CT apparatus 101 or the MRI apparatus 102) that has received the imaging request 202 performs imaging of the patient 1. After the imaging is completed, the modality 105 transmits the acquired image (the CT image 6 or the MRI image 7) to the DICOM server 253.

[0112] The DICOM server 253 stores the transmitted image (CT image 6 or MRI image 7). Here, by associating the patient information 245 included in the imaging request 202 with the patient information 245 stored in the HIS server 254, at least one of the first information 241 and the second information 242 stored in the HIS server 254 and the patient information 245 can be stored in the header of the transmitted image. In addition, the DICOM server 253 transmits imaging completion information 203 indicating that imaging of the image (CT image 6 or MRI image 7) has been completed to the HIS server 254.

[0113] The HIS server 254 that has received the imaging completion information 203 stores the fact that imaging in the transmitted imaging request 202 has been completed.

[0114] Moreover, the modality 105 transmits requests (requests 204, 206, and 207) to the server 250 to obtain the first information 241, the second information 242, and an image (the CT image 6 or the MRI image 7).

[0115] Specifically, when diagnosing cerebral infarction, image viewing terminal 80 is configured to acquire an image (CT image 6 or MRI image 7) from DICOM server 253 by being operated by a doctor or the like. Image viewing terminal 80 transmits an image transmission request 204 to DICOM server 253 by being operated by a doctor or the like. DICOM server 253 receiving image transmission request 204 transmits an image (CT image 6 or MRI image 7) to image viewing terminal 80. For example, the doctor or the like creates diagnostic report 205 regarding a stenosis site or the like based on the image (CT image 6 or MRI image 7) transmitted to image viewing terminal 80. The created diagnostic report 205 is transmitted to DICOM server 253, for example. DICOM server 253 stores the transmitted diagnostic report 205.

[0116] Furthermore, when treating cerebral infarction, the blood vessel X-ray imaging device 270 transmits requests 206 and 207 to the server 250 in order to obtain at least one of the first information 241 and the second information 242, and an image (a CT image 6 or an MRI image 7). The blood vessel X-ray imaging device 270 obtains the information and images transmitted from the server 250 in response to requests 206 and 207.

[0117] Now, with reference to FIG. 11, a configuration in which server 250 transmits at least one of first information 241 and second information 242, and an image (CT image 6 or MRI image 7) to angiographic apparatus 270 will be described.

[0118] 11, the blood vessel X-ray imaging apparatus 270 is configured to be operated by a doctor or the like to transmit a request 206 to the RIS server 252 to acquire at least one of the first information 241 and the second information 242. When transmitting the transmission request 206, the blood vessel X-ray imaging apparatus 270 also transmits the identification information 245a.

[0119] The RIS server 252 that receives the request 206 transmits the request 206 and the identification information 245 a to the HIS server 254 .

[0120] The HIS server 254 that has received the request 206 transmits, to the RIS server 252, at least one of the first information 241 and the second information 242 linked to the identification information 245a, based on the received identification information 245a.

[0121] The RIS server 252 transmits at least one of the received first information 241 and second information 242 to the angiography apparatus 270.

[0122] Furthermore, the blood vessel X-ray imaging apparatus 270 transmits a transmission request 207 for an image (CT image 6 or MRI image 7) to the DICOM server 253 based on an operation by a doctor or the like. When transmitting the transmission request 207, the blood vessel X-ray imaging apparatus 270 also transmits the identification information 245a.

[0123] The DICOM server 253, which has received the transmission request 207, identifies an image of the patient 1 (CT image 6 or MRI image 7) from among the multiple stored images (CT image 6 or MRI image 7) based on the identification information 245a. The DICOM server 253 transmits the identified image (CT image 6 or MRI image 7) to the angiography apparatus 270 via the RIS server 252.

[0124] That is, the server 250 is configured to associate the second information 242 with the CT image 6 or the MRI image 7 of the patient 1 by using the identification information 245a. The server 250 is also configured to transmit at least one of the first information 241 and the second information 242 to the blood vessel X-ray imaging device 270. In this embodiment, the server 250 is configured to transmit the CT image 6 or the MRI image 7 of the patient 1 and the second information 242 to the blood vessel X-ray imaging device 270 based on the request 206 and the request 207 from the blood vessel X-ray imaging device 270.

[0125] In this embodiment, the RIS server 252 transmits at least one of the first information 241 and the second information 242 to the angiographic X-ray apparatus 270, but if at least one of the first information 241 and the second information 242 is stored in the CT image 6 or the MRI image 7 of the patient 1 stored in the DICOM server 253, it is not necessary for the RIS server 252 to transmit at least one of the first information 241 and the second information 242. In this case, at least one of the first information 241 and the second information 242 can be stored in the header of the CT image 6 or the MRI image 7 of the patient 1.

[0126] (Transmission process of the first information and / or the second information) Next, a process in which the server 250 generates the first information 241 and the second information 242 will be described with reference to FIG.

[0127] In step 301, the detection device 210 measures a biological sample 2 collected from a patient 1, and generates gene-related information 240 related to susceptibility genes for cerebral infarction. The detection device 210 transmits the generated gene-related information 240 to the server 250.

[0128] In step 302, the detection device 210 sets the identification information 245a of the patient 1 in the gene-related information 240.

[0129] In step 303, the server 250 associates the set identification information 245a of the patient 1 with the patient identification information 245a stored in the server 250.

[0130] In step 304, the server 250 manages at least one of the identification information 245a of the patient 1 stored in the server 250 and the patient information 245 of the patient 1 related to the identification information 245a of the patient 1 in association with the gene-related information 240. The gene-related information 240 includes first information 241 indicating whether the biological sample 2 has a susceptibility gene for cerebral infarction or not, and second information 242 related to the susceptibility gene generated based on the first information 241. In this embodiment, the server 250 manages at least one of the identification information 245a of the patient 1 stored in the server 250 and the patient information 245 of the patient 1 related to the identification information 245a of the patient 1 in association with at least one of the first information 241 and the second information 242. Specifically, the server 250 manages the second information 242 in association with the patient information 245.

[0131] In step 305, the server 250 determines whether or not there is a request 206 to transmit the first information 241 and / or the second information 242 from the blood vessel X-ray imaging apparatus 270. If there is a request 206, the process proceeds to step 306. If there is no request 206, the process ends.

[0132] In step 306, the server 250 transmits at least one of the first information 241 and the second information 242 to the blood vessel X-ray imaging apparatus 270. Then, the process ends.

[0133] (Deletion of first information) In this embodiment, the HIS server 254 is configured to delete the first information 241 immediately after associating the second information 242 with the patient information 245, or after a preset period has elapsed, or based on information 208 (see FIG. 10 ) indicating the end of treatment from the blood vessel X-ray imaging device 270, and to store the second information 242 in a state associated with the patient information 245. In this embodiment, the HIS server 254 is configured to delete the first information 241 based on information 208 indicating the end of treatment from the blood vessel X-ray imaging device 270, after associating the second information 242 with the patient information 245.

[0134] Next, with reference to FIG. 13, a deletion process of the first information 241 in the case where the first information 241 is deleted based on the information 208 (see FIG. 10) indicating the end of treatment will be described.

[0135] In step 401, the server 250 determines whether or not information 208 indicating the end of treatment has been transmitted from the blood vessel X-ray imaging apparatus 270. If the server 250 receives information 208 indicating the end of treatment from the blood vessel X-ray imaging apparatus 270, the process proceeds to step 402. If the server 250 does not receive information 208 indicating the end of treatment from the blood vessel X-ray imaging apparatus 270, the server 250 repeats the process of step 401.

[0136] In step 402, the server 250 deletes the first information 241. Then, the process ends.

[0137] (Transmission of second information and CT or MRI images) Next, a process in which the server 250 transmits the second information 242 and the CT image 6 or the MRI image 7 of the patient 1 to the angiographic X-ray apparatus 270 will be described with reference to FIG.

[0138] In step 410, the DICOM server 253 determines whether or not there is a transmission request 207 for an image (CT image 6 or MRI image 7) from the blood vessel X-ray imaging device 270. If there is a transmission request for an image, the process proceeds to step 411. If there is no transmission request for an image, the process of step 410 is repeated. When the transmission request 207 is transmitted from the blood vessel X-ray imaging device 270, the identification information 245a is also transmitted.

[0139] Next, in step 411, the DICOM server 253 (server 250) associates the second information 242 with the CT image 6 or MRI image 7 of the patient 1 using the identification information 245a. Specifically, upon receiving the transmission request 207, the DICOM server 253 identifies the image of the patient 1 (CT image 6 or MRI image 7) from among the multiple stored images (CT image 6 or MRI image 7) based on the identification information 245a, thereby associating the second information 242 with the image (CT image 6 or MRI image 7).

[0140] Next, in step 412, the DICOM server 253 (server 250) transmits the specified image (CT image 6 or MRI image 7) to the blood vessel X-ray imaging apparatus 270 via the RIS server 252. That is, the DICOM server 253 (server 250) transmits the CT image 6 or MRI image 7 of the patient 1 and the second information 242 to the blood vessel X-ray imaging apparatus 270 based on the request 206 and the request 207 from the blood vessel X-ray imaging apparatus 270. Thereafter, the process ends.

[0141] (Angiography equipment) The angiography apparatus 270 (see FIG. 11) installed in the catheter room 902 is, for example, the angiography apparatus 500 shown in FIG 15. An example of the configuration of the angiography apparatus 500 will be described in detail below.

[0142] (Configuration of the angiography device) As shown in Figures 15 and 16, the angiography apparatus 500 of this embodiment includes a tabletop 501 on which a patient 1 rests, an imaging unit 502 including an X-ray source 521 and a detection unit 522, an image processing unit 503, a control unit 504, and a display unit 505.

[0143] The top board 501 is formed in a rectangular flat plate shape in a plan view. The top board 501 is placed on the top board so that the head-foot direction of the patient 1 is along the long side of the rectangle and the left-right direction of the patient 1 is along the short side of the rectangle. In this specification, the head-foot direction of the patient 1 is defined as the X direction, the left-right direction of the patient 1 is defined as the Z direction, and the direction perpendicular to the X direction and the Z direction is defined as the Y direction.

[0144] The imaging section 502 is configured to irradiate the patient 1 with X-rays from an X-ray source 521 and to detect the X-rays that have passed through the patient 1 in a detection section 522 .

[0145] 16(b), the X-ray source 521 is attached to one end of a C-shaped holding part 523. The X-ray source 521 is capable of irradiating the patient 1 with X-rays by applying a voltage thereto by an X-ray tube driving part (not shown). The X-ray source 521 has a collimator capable of adjusting the X-ray irradiation field, which is the irradiation range of the X-rays.

[0146] The detector 522 is attached to the other end of the holder 523. That is, the detector 522 is disposed on the opposite side of the top plate 501 from the X-ray source 521. The detector 522 is disposed to face the X-ray source 521, and is configured to be able to detect X-rays that have passed through the patient 1. The detector 522 includes, for example, an FPD (flat panel detector).

[0147] 15, the image processing unit 503 is a computer including a processor such as a GPU (Graphics Processing Unit) or an FPGA (Field-Programmable Gate Array) configured for image processing. The image processing unit functions as an image processing device by executing an image processing program.

[0148] The image processor 503 is configured to generate a perspective image 520 (see FIG. 17) of the patient 1 based on the detection signal output from the detector 522.

[0149] The control unit 504 is a computer including a CPU (Central Processing Unit), a ROM (Read Only Memory), a RAM (Random Access Memory), and the like.

[0150] The control unit 504 is configured to acquire the CT image 6 or the MRI image 7 from the server 506. The server 506 has a similar configuration to the server 250 (see FIGS. 10 and 11), and therefore a detailed description thereof will be omitted.

[0151] As shown in FIG. 15, the control unit 504 is configured to acquire a CT image 6 or an MRI image 7 of the patient 1 undergoing fluoroscopy from the server 506 based on patient information 545 of the patient 1 undergoing fluoroscopy.

[0152] The control unit 504 is configured to select, from among the CT images 6 or MRI images 7 of the patient 1 undergoing fluoroscopic imaging, a CT image 6 or an MRI image 7 having the same spatial coordinates as the fluoroscopic image 520 generated by the image processing unit 503. Fig. 17 is a schematic diagram showing a process of generating a superimposed image 530 of the head 550 of the patient 1. The control unit 504 is configured to perform control to superimpose (layer) the fluoroscopic image 520 on the acquired CT image 6 or MRI image 7 and display it on the display unit 505.

[0153] 17, when a treatment position (thrombus site) 511 is associated with a CT image 6 or an MRI image 7, the control unit 504 is configured to perform control to display the treatment position 511 on the display unit 505 together with a superimposed image 530. In Fig. 17, a mark 531 is attached to the treatment position 511. The mark 531 may be a figure surrounding the treatment position 511, or an arrow may be displayed.

[0154] The control unit 504 is configured to control the acquisition of genetic information 540, which coincides with patient information 545 of the patient 1 undergoing fluoroscopic imaging, from the server 506. The genetic information 540 includes at least one of the first information 541 and the second information 542. The first information 541 is the same as the first information 41 (see FIG. 4). That is, the first information 541 includes patient information 545 and information on the presence / absence of genetic polymorphism. The second information 542 is the same as the second information 42 (see FIG. 4). That is, the second information 542 includes at least one of information 42a on the type of cerebral infarction, information 42b on the cerebral blood vessels of the patient 1, and information 42c indicating a treatment device whose use is recommended or not recommended in the cerebral infarction catheter treatment of the patient 1.

[0155] The control unit 504 is configured to perform control to display genetic information 540 on an image in which the fluoroscopic image 520 and the CT image 6 or the MRI image 7 are superimposed on the display unit 505. The control unit 504 is configured to perform control to display the genetic information 540 at a position that does not overlap the treatment position 511. As shown in Fig. 17, when a mark 531 indicating the treatment position 511 is displayed, the position that does not overlap the mark 531 is a position that does not overlap the mark 531.

[0156] The display unit 505 is a monitor attached to the angiography device 500. As shown in FIG. 17, the catheter 512 is clearly captured in the fluoroscopic image 520, but the blood vessel 513 is not clear. Therefore, by superimposing the CT image 6 or the MRI image 7, a superimposed image 530 in which the catheter 512 and the blood vessel 513 are superimposed is generated. As shown in FIG. 17, in the superimposed image 530, the pixel value of the blood vessel 513 is inverted to make the catheter 512 clear. In FIG. 17, the pixel value of the blood vessel 513 is white to indicate that it has been inverted. In addition, the pixel value of the catheter 512 may be inverted. In addition, a mark 531 indicating the treatment position 511 and genetic information 540 are displayed on the superimposed image. In FIG. 17, the genetic information 540 is expressed by characters. The superimposed image 530, the treatment position 511, and the genetic information 540 are displayed on the display unit 505 attached to the angiography device 500, so that a doctor or the like can check them during treatment. The displayed genetic information 540 is at least one of first information 541 and second information 542.

[0157] (Flow of diagnosis by doctor, etc.) When a patient 1 suffering from cerebral infarction is transported to a hospital, a doctor or the like takes a CT image 6 or an MRI image 7.

[0158] In CT imaging, a patient is imaged from multiple directions while rotating and moving the imaging unit. As shown in FIG. 18(a), multiple two-dimensional image data are generated in CT imaging. FIG. 18(a) shows an image captured while moving in the head-to-foot direction (X direction). Then, as shown in FIG. 18(b), multiple two-dimensional CT images 6 captured continuously are reconstructed to generate three-dimensional image data. A desired CT image 6 can be obtained by cutting the three-dimensional data in any direction. For example, when a blood vessel 513 extends along the head-to-foot direction, the reconstructed three-dimensional image data may be cut in a direction parallel to the head-to-foot direction (X direction) as shown in FIG. 18(c).

[0159] In addition, three-dimensional image data can be generated by reconstructing the MRI image 7. An image of the blood vessel 513 can be generated by cutting the generated three-dimensional image data in the direction in which the blood vessel extends.

[0160] The doctor or the like confirms the treatment position 511, which is the treatment position, from the CT image 6 or MRI image 7 taken in the image reading room 901. The doctor or the like selects the treatment position 511 of the CT image 6 or MRI image 7, whereby the treatment position 511 is marked and the treatment position 511 and the CT image 6 or MRI image 7 are associated with each other.

[0161] In the case of CT image 6, a doctor or the like can identify treatment position 511 based on the CT value, which is the absorption value of X-rays. In the case of cerebral infarction, a blood vessel 513 at treatment position 511 has a thrombus. A thrombus absorbs X-rays more than a blood vessel to which a contrast agent has been administered, and therefore has a higher CT value, and is displayed as black compared to blood vessels without a thrombus. A doctor or the like can identify treatment position 511 based on the difference in CT value.

[0162] In the case of the MRI image 7, a doctor or the like can identify the treatment position 511 by the detection signal. Since the detection signal is strong where the blood flow is fast and weak where the blood flow is slow, blood vessels with slow blood flow (where cerebral infarction has occurred) are displayed darker than other blood vessels. Therefore, a doctor or the like can identify the treatment position 511.

[0163] After taking the CT image 6 and the MRI image 7 of the patient 1, the doctor starts treatment to remove the thrombus. As shown in FIG. 17, when the doctor starts fluoroscopic imaging for treatment, a superimposed image 530 in which the fluoroscopic image 520 and the CT image 6 or the MRI image 7 are superimposed, and genetic information 540 are displayed on the display unit 505. As shown in FIG. 17, a mark 531 is placed on the treatment position 511 of the CT image 6 or the MRI image 7, so that the doctor performing the treatment and the doctor performing the diagnosis in the image reading room 901 can confirm the treatment position 511. Since the superimposed image 530 and the genetic information 540 are displayed on the display unit 505, the doctor can perform the surgery smoothly.

[0164] Next, the operation of fluoroscopic imaging by the angiography apparatus 500 will be described with reference to FIG.

[0165] In step 601, the angiography apparatus 500 starts fluoroscopic imaging of angiography by receiving an input from the user. When fluoroscopic imaging of angiography starts, the angiography apparatus 500 irradiates X-rays from the X-ray source 521 to the patient 1. The detection unit 522 detects the X-rays that have passed through the patient 1, and outputs a detection signal.

[0166] In step 602, the image processor 503 generates a perspective image 520 based on the detection signal.

[0167] In step 603 , the control unit 504 performs control to acquire, from the server 506 , the CT image 6 or the MRI image 7 having the same spatial position coordinates as the fluoroscopic image 520 generated in step 602 .

[0168] In step 604, the control unit 504 performs control to superimpose the fluoroscopic image 520 on the acquired CT image 6 or MRI image 7 and display it on the display unit 505.

[0169] In step 605, the control unit 504 performs control to acquire genetic information 540 that matches the patient information 545 from the server.

[0170] In step 606, the control unit 504 controls the display unit 505 to display the acquired genetic information 540, the superimposed image 530 in which the CT image 6 or MRI image 7 and the fluoroscopic image 520 are superimposed.

[0171] (Effects of this embodiment) In this embodiment, the following effects can be obtained.

[0172] As described above, the cerebral infarction treatment support system 100 of this embodiment includes a detection device 10 that measures a biological sample 2 collected from a patient 1 and generates first information 41 indicating whether or not the biological sample 2 has a susceptibility gene for cerebral infarction, a display unit 30 that is arranged in at least one of a catheter room 902 in which a vascular X-ray imaging device 70 is arranged, and a reading room 901 in which an image viewing terminal 80 for radiological diagnostic images or MRI images is arranged, and an image control unit 20 that controls the display unit 30. The image control unit 20 includes a receiving unit 21 that receives at least one of the first information 41 generated by the detection device 10 and second information 42 related to the susceptibility gene generated based on the first information 41, and a video output unit 22 that outputs at least one of the received first information 41 and second information 42 to the display unit 30.

[0173] Furthermore, as described above, the cerebral infarction treatment support method of this embodiment includes the steps of measuring a biological sample 2 collected from a patient 1 and generating first information 41 indicating whether or not the biological sample 2 has a susceptibility gene for cerebral infarction, receiving at least one of the generated first information 41 and second information 42 related to the susceptibility gene generated based on the first information 41, and outputting at least one of the received first information 41 and second information 42 to a display unit 30, the display unit 30 being arranged in at least one of a catheter room 902 in which a vascular X-ray imaging device 70 is arranged and a reading room 901 in which an image viewing terminal 80 for radiological diagnostic images or MRI images is arranged.

[0174] In the cerebral infarction treatment support system 100 and the cerebral infarction treatment support method of this embodiment, by the above configuration, when treating a cerebral infarction patient 1 in the acute phase, at least one of the first information 41 indicating whether the patient 1 has a susceptibility gene related to cerebral infarction or not and the second information 42 generated based on the first information 41 can be displayed on the display unit 30 (second display unit 82) arranged in the image reading room 901 where the type of cerebral infarction is determined, the location of the thrombus is specified, etc. In this way, if at least one of the first information 41 and the second information 42 is displayed at the time of diagnosis where the type of cerebral infarction is determined, the location of the thrombus is specified, etc., the doctor can determine the type of cerebral infarction in consideration of information based on the presence or absence of susceptibility genes that cannot be obtained from image information, in addition to the conventional interpretation of the CT image 6 or MRI image 7. Furthermore, if at least one of the first information 41 and the second information 42 is displayed during treatment on the display unit 30 (first display unit 72) arranged in the catheterization room 902 where treatment is performed for the patient 1 who has developed cerebral infarction, the doctor actually performing the treatment can select a treatment device for catheter treatment according to the type of cerebral infarction, taking into consideration the information based on the presence or absence of susceptibility genes. As described above, support information useful for doctors to identify the type of cerebral infarction during diagnosis and treatment of acute cerebral infarction can be presented.

[0175] In the above embodiment, further advantages can be obtained by configuring as follows.

[0176] That is, in the above embodiment, the image control unit 20 is configured to receive at least the second information 42 and output it to the display unit 30, and the second information 42 includes at least one of information 42a on the type of cerebral infarction, information 42b on the cerebral blood vessels of the patient 1, and information 42c indicating a treatment device whose use is recommended or not recommended in cerebral infarction catheter treatment of the patient 1. With this configuration, it is possible to present particularly useful support information to doctors involved in the diagnosis and treatment of acute cerebral infarction as the second information 42 derived based on the first information 41 on whether or not a susceptibility gene for cerebral infarction is present.

[0177] In the above embodiment, the detection device 10 assigns the patient information 45 of the patient 1 from whom the biological sample 2 was collected to the first information 41, and the image control unit 20 receives an image of the patient 1 to which the patient information 45 has been assigned, and outputs the image having the same patient information 45 and at least one of the first information 41 and the second information 42 to the display unit 30. With this configuration, it is possible to link the image used for treatment or diagnosis with the first information 41 and / or the second information 42 via the patient information 45. Therefore, even in an emergency such as treatment or diagnosis of the patient 1 with acute cerebral infarction, these images and information can be collected and reliably provided to the doctor without relying on unreliable means of communication such as oral communication.

[0178] Furthermore, in the above embodiment, the image control unit 20 includes a first control device 71 provided in the angiographic X-ray apparatus 70 installed in the catheter room 902, and the display unit 30 includes a first display unit 72 installed in the catheter room 902 and displaying an X-ray image 73 of the angiographic X-ray apparatus 70. With this configuration, the first information 41 and / or the second information 42 can be received by the angiographic X-ray apparatus 70 used when performing catheter treatment and displayed on the display unit 30. Therefore, there is no need to provide a dedicated device for displaying the first information 41 and / or the second information 42, and the system configuration can be simplified.

[0179] Furthermore, in the above embodiment, the first control device 71 is configured to output at least one of the received first information 41 and second information 42 and an X-ray image 73 of the patient 1 taken by the angiographic X-ray device 70 to the first display unit 72 during catheter treatment of the patient 1 in the catheter room 902. With this configuration, the first information 41 and / or the second information 42 can be displayed together with the X-ray image 73 of the catheter during the catheter treatment. Therefore, the first information 41 and / or the second information 42 can be reliably presented to the doctor actually performing the catheter treatment.

[0180] In the above embodiment, the image control unit 20 includes a second control device 81 provided in the image viewing terminal 80 installed in the image reading room 901, and the display unit 30 includes a second display unit 82 installed in the image reading room 901 and performing screen display of the image viewing terminal 80. With this configuration, the first information 41 and / or the second information 42 can be received by the image viewing terminal 80 in the image reading room 901 used in diagnosing the patient 1 who has developed cerebral infarction, and displayed on the display unit 30. Therefore, there is no need to provide a dedicated device for displaying the first information 41 and / or the second information 42, and the system configuration can be simplified.

[0181] In the above embodiment, the second control device 81 is configured to receive at least one of the first information 41 and the second information 42 and the CT image 6 or the MRI image 7 of the patient 1 at the time of diagnosis of the patient 1 in the reading room 901, and output them to the second display unit 82. With this configuration, at the time of diagnosis of the patient 1 who has developed cerebral infarction, the first information 41 and / or the second information 42 can be displayed together with the CT image 6 or the MRI image 7 used for diagnosis. Therefore, the first information 41 and / or the second information 42 can be reliably presented to a doctor who actually identifies the type of cerebral infarction.

[0182] In the above embodiment, the system further includes a server 50 that is communicatively connected to the detection device 10 and the image control unit 20 and stores the first information 41, the server 50 generates the second information 42 based on the first information 41, and the image control unit 20 receives at least the second information 42 from the server 50. With this configuration, the second information 42 can be automatically generated based on the first information 41 generated by the detection device 10 and presented to a doctor or the like during treatment or diagnosis. Therefore, even in an emergency such as during treatment or diagnosis of a patient 1 with acute cerebral infarction, useful support information can be reliably presented to a doctor involved in diagnosis or treatment.

[0183] In the above embodiment, the server 50 includes at least one of a radiology information system server (RIS server 52) and a medical image management system server (DICOM server 53) connected to a network in the hospital. With this configuration, the second information 42 can be generated by the server (52 or 53) of the existing network constructed in the hospital. Since each of the above servers (52 or 53) handles radiological images or medical images, the images (CT images 6, MRI images 7, X-ray images 73 during treatment) referred to by a doctor during treatment or diagnosis of a patient 1 with cerebral infarction can be easily linked to the second information 42, and managed and provided.

[0184] In the above embodiment, the susceptibility gene for cerebral infarction includes the RNF213p.R4810K gene polymorphism. With this configuration, the first information 41 on whether or not the patient 1 has the RNF213p.R4810K gene polymorphism can be presented to a doctor. Based on this first information 41, the doctor or the like can obtain knowledge useful for treatment and diagnosis, such as that the type of cerebral infarction suffered by the patient 1 is significantly more likely to be atherothrombotic cerebral infarction, that the diameter of the main cerebral blood vessels tends to be small, and as a result, caution is required when using a thrombus retrieval device during catheter treatment, and even if a thrombus retrieval device is used, it is preferable to use a thrombus retrieval device with a smaller diameter than usual.

[0185] In the above embodiment, the detection device 10 includes a gene amplification detection device configured to perform a gene amplification process on a biological sample 2 containing a specimen 2a containing blood or saliva collected from a patient 1 and a reaction solution 2c containing a component that suppresses the effect of an inhibitory substance in the specimen 2a. With this configuration, the detection device 10 can directly measure the biological sample 2 collected from the patient 1 and generate the first information 41 without a purification process for removing inhibitors in the biological sample 2 and purifying the genes. Therefore, compared to the case where a purification process is performed, a part of the pre-processing (purification process) for the measurement by the detection device 10 is not required, so that the first information 41 can be generated quickly. Therefore, the above configuration is particularly useful in that the first information 41 can be provided to a doctor as early as possible in an emergency such as treatment or diagnosis of a patient 1 with acute cerebral infarction.

[0186] In the above embodiment, the detection device 10 includes a gene amplification detection device that performs a real-time PCR method in which a labeling process is performed using a labeling substance during the gene amplification process. With this configuration, the first information 41 can be generated more quickly than with a normal (non-real-time) PCR method in which amplification is performed and then a labeling process is performed. Therefore, the above configuration is particularly useful in that the first information 41 can be provided to a doctor as early as possible in an emergency such as treatment or diagnosis of a patient 1 with acute cerebral infarction.

[0187] Furthermore, the above embodiment further includes a step of adding patient information 45 of patient 1 to the first information 41 generated from the biological sample 2 collected from patient 1 brought in as an emergency patient, and at least one of the received first information 41 and second information 42 is displayed on the display unit 30 together with the patient information 45 at least until the time of treatment of patient 1. With this configuration, even in an emergency such as treatment of patient 1 with acute cerebral infarction, it is possible to identify patient 1 based on the patient information 45 and reliably present the first information 41 together with the patient information 45 to a doctor.

[0188] [Example] The present inventors have examined the presence or absence of the RNF213 p.R4810K polymorphism in patients who have developed cerebral infarction. The results (cases) will be described.

[0189] The inventors of the present application took MRI images and MRA (Magnetic Resonance Angiography) images of one patient who had been rushed to the hospital, and confirmed that the patient had developed cerebral infarction in a major cerebral artery.

[0190] The present inventor performed a treatment to remove a thrombus from a blood vessel on the patient using a thrombus aspiration device 5b (cerebral infarction treatment 1). After performing cerebral infarction treatment 1, re-occlusion was observed in the patient's blood vessel. The present inventor then performed a treatment to dilate the blood vessel using a percutaneous transluminal angioplasty device 5c (cerebral infarction treatment 2). After performing cerebral infarction treatment 2, re-occlusion was observed in the patient's blood vessel, so the present inventor performed a treatment to dilate the blood vessel again using a percutaneous transluminal angioplasty device 5c (cerebral infarction treatment 3). In addition, a test was performed to determine whether the patient had the RNF213 p.R4810K genetic polymorphism. As a result, the patient had the RNF213 p.R4810K genetic polymorphism.

[0191] It is known that the cause of vascular reocclusion is related to intracranial arterial stenosis, which narrows the blood vessels, but in this case, intracranial arterial stenosis was not clear. As a result of the study by the present inventor, it was concluded that patients with the RNF213 p.R4810K genetic polymorphism tend to have narrower blood vessels (intracranial vascular endothelial fragility) compared to patients without this genetic polymorphism, and therefore endothelial damage of the blood vessels may have occurred due to physical stimulation during thrombus removal with a stent, resulting in vascular reocclusion. Thus, it was confirmed that patients with the RNF213 p.R4810K genetic polymorphism and fragile vascular endothelium have a relatively high risk of vascular reocclusion.

[0192] Therefore, if information on whether or not a patient has the RNF213 p.R4810K polymorphism is provided beforehand before treatment as in the above embodiment, it is possible to make the doctor understand that it is necessary to avoid a treatment device that directly contacts the blood vessel, and to pay attention not to give physical stimulation to the blood vessel even if a treatment device that does not contact the blood vessel is used. Furthermore, the above results suggest that genetic information may also be useful in evaluating the risk of reocclusion after surgery.

[0193] [Variations] The embodiments disclosed herein should be considered to be illustrative and not restrictive in all respects. The scope of the present invention is indicated by the claims, not by the description of the embodiments above, and further includes all modifications (variations) within the meaning and scope of the claims.

[0194] For example, in the above embodiment, the second information 42 includes at least one of the information 42a on the type of cerebral infarction, the information 42b on the cerebrovascular system, and the device information 42c, but the present invention is not limited to this. The second information 42 may include information other than the above information as long as it is information derived from the first information 41.

[0195] In the above embodiment, the patient information 45 is added to the first information 41, but the present invention is not limited to this. In the present invention, the patient information 45 does not have to be added to the first information 41.

[0196] In the above embodiment, an example has been shown in which an image such as a CT image 6, an MRI image 7, or an X-ray image 73 and at least one of the first information 41 and the second information 42 are displayed on the display unit 30, but the present invention is not limited to this. At least one of the first information 41 and the second information 42 may be displayed on the display unit 30 without displaying an image.

[0197] In the above embodiment, the detection device 10 is a PCR device, but the present invention is not limited to this. The detection device 10 may perform a PCR process on a biological sample 2 that has been prepared by performing a purification process to purify DNA from a specimen 2a.

[0198] In the above embodiment, the detection device 10 performs real-time PCR, but the present invention is not limited to this. The detection device 10 may be configured to perform non-real-time PCR.

[0199] [Aspects] It will be appreciated by those skilled in the art that the exemplary embodiments described above are examples of the following aspects.

[0200] (Item 1) A detection device that measures a biological sample collected from a patient and generates first information on whether the biological sample contains a susceptibility gene related to cerebral infarction; A cerebral infarction treatment support system comprising: a management unit configured to communicate with the detection device, receiving information based on the presence or absence of the susceptibility gene, and associating and managing the information based on the presence or absence of the susceptibility gene with information linked to the patient.

[0201] (Item 2) The management unit includes a RIS / HIS server, 2. The cerebral infarction treatment support system according to item 1, wherein the information linked to the patient includes a patient name managed by the RIS / HIS server.

[0202] (Item 3) The management unit includes a DICOM server, 3. The cerebral infarction treatment support system according to item 1 or 2, wherein the information linked to the patient includes a radiological diagnostic image or an MRI image obtained in advance.

[0203] (Item 4) 4. The cerebral infarction treatment support system according to any one of items 1 to 3, wherein the susceptibility gene for cerebral infarction includes a gene polymorphism of RNF213 p.R4810K.

[0204] (Item 5) 5. The cerebral infarction treatment support system according to any one of items 1 to 4, wherein the detection device includes a gene amplification detection device configured to perform a gene amplification process on the biological sample containing a specimen including blood or saliva collected from the patient and a reaction solution including a component that suppresses the effect of an inhibitory substance in the specimen.

[0205] (Item 6) 6. The cerebral infarction treatment support system according to any one of items 1 to 5, wherein the detection device includes a gene amplification detection device that performs a real-time PCR method in which labeling treatment is performed with a labeling substance during the gene amplification process. [Explanation of symbols]

[0206] 1 patient 2. Biological samples 2a Sample 2c Reaction solution 5. Treatment Devices 6 CT images 7. MRI images 10. Detection Device 20 Image control section 21 Receiving section 22 Video output section 30 Display section 41 1st information 42 Second information 42a Information on types of cerebral infarction 42b Patient's cerebrovascular information 42c Device information (information indicating the treatment device) 45 Patient Information 50 Servers 52 Server 52 RIS Server (Radiology Information System Server) 53 DICOM Server (Medical Image Management System Server) 70 Vascular X-ray Equipment 71 First control device 72 1st display section 73 X-ray image 80 Image viewing terminal 81 Second control device 82 2nd display section 100 Stroke Treatment Support System 901 Reading Room 902 Catheterization Lab

Claims

1. a detection device that measures a biological sample collected from a patient, generates first information on whether the biological sample contains a susceptibility gene for cerebral infarction, and adds patient information of the patient to the first information; A cerebral infarction treatment support system comprising: a management unit configured to communicate with the detection device, receiving information based on the presence or absence of the susceptibility gene, and associating and managing the information based on the presence or absence of the susceptibility gene with information linked to the patient.

2. The management unit includes a RIS / HIS server; The cerebral infarction treatment support system according to claim 1 , wherein the information linked to the patient includes a patient name managed by the RIS / HIS server.

3. The management unit includes a DICOM server, The cerebral infarction treatment support system according to claim 1 , wherein the information linked to the patient includes a radiological diagnostic image or an MRI image acquired in advance.

4. The cerebral infarction treatment support system according to claim 1 , wherein the susceptibility gene for cerebral infarction includes a gene polymorphism of RNF213 p.R4810K.

5. 2. The cerebral infarction treatment support system according to claim 1, wherein the detection device includes a gene amplification detection device configured to perform a gene amplification process on the biological sample containing a specimen including blood or saliva collected from the patient and a reaction solution including a component that suppresses the effects of inhibitors in the specimen.

6. 2. The cerebral infarction treatment support system according to claim 1, wherein the detection device includes a gene amplification detection device that performs a real-time PCR method in which labeling treatment is performed with a labeling substance during the gene amplification process.

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