Medicine container

Abstract

A drug container is provided that includes at least one sidewall and an extension. The extension may be rigid relative to the sidewall that defines the volume of the container. The extension may extend to a central region of the container substantially within the volume of the container. The container may include one or more ribs formed in the sidewall to provide structural rigidity to the sidewall.

Description

[Technical field]

[0001] The disclosed embodiments relate to medication containers and related methods of use. [Background technology]

[0002] The drug container is used to hold a therapeutic fluid. Such therapeutic fluid may be delivered to a patient via parenteral delivery (e.g., subcutaneous injection, intramuscular injection, intravenous injection), via enteral delivery (e.g., via a gastric or duodenal feeding tube), or by any other suitable route of administration. The drug container may be configured to controllably release the therapeutic fluid for delivery to the patient. A healthcare provider typically specifies a prescribed amount of the drug to be administered to the patient. Summary of the Invention

[0003] In some embodiments, the drug container comprises a sidewall, a spout coupled to the sidewall, and an extension coupled to the spout. The sidewall may at least partially define an interior volume of the drug container. The spout may be configured to allow the drug to flow out of the interior volume of the drug container. The extension may be disposed within the interior volume of the drug container. The sidewall may have a greater flexibility than the extension such that the drug container has a collapsed state when empty and an expanded state when full. The sidewall may be configured to move as the drug flows out of the interior volume of the drug container through the spout. A height of the extension measured along a central axis of the spout may be at least one-quarter of a sidewall height measured along a dimension parallel to the central axis of the spout when the drug container is in an expanded state.

[0004] In some embodiments, the drug container comprises a sidewall, a spout coupled to the sidewall, and an extension coupled to the spout. The sidewall may at least partially define an interior volume of the drug container. The spout may be configured for the drug to flow out of the interior volume of the drug container. The extension may be disposed within the interior volume of the drug container. The sidewall may have greater flexibility than the extension such that the drug container has a collapsed state when empty and an expanded state when full. The sidewall may be configured to move as the drug flows out of the interior volume of the drug container through the spout. The extension may comprise a first end and a second end, the first end being closer to the spout than the second end. A cross-sectional area of ​​the extension measured perpendicular to a central axis of the spout may be greater at the first end than at the second end, and the central axis may be parallel to a direction of flow through the spout.

[0005] It should be appreciated that the foregoing concepts, and additional concepts discussed below, may be arranged in any suitable combination, as the disclosure is not limited in this respect. Moreover, other advantages and novel features of the present disclosure will become apparent from the following detailed description of various non-limiting embodiments when considered in conjunction with the accompanying drawings. [Brief description of the drawings]

[0006] The accompanying drawings are not intended to be drawn to scale. In the drawings, each identical or nearly identical component illustrated in various figures may be represented by a similar numeral. For purposes of clarity, not every component may be numbered in every drawing. In the drawings, [Figure 1] FIG. 2 is a perspective top view of one embodiment of a drug container. [Diagram 2] FIG. 2 is a front view of the drug container of FIG. [Diagram 3] FIG. 13 is a front view of another embodiment of a drug container. [Figure 4] FIG. 13 is a perspective front view of yet another embodiment of a drug container. [Figure 5A]5 is a series of perspective cross-sectional views of the drug container of FIG. 4 taken along lines AA, BB, and CC, respectively. [Figure 5B] 5 is a series of perspective cross-sectional views of the drug container of FIG. 4 taken along lines AA, BB, and CC, respectively. [Figure 5C] 5 is a series of perspective cross-sectional views of the drug container of FIG. 4 taken along lines AA, BB, and CC, respectively. [Figure 6A] FIG. 5 is a cross-sectional view taken along DD of the drug container of FIG. 4. [Figure 6B] FIG. 5 is a right side view of the drug container of FIG. [Figure 7A] FIG. 13 is a perspective top view of yet another embodiment of a drug container. [Figure 7B] FIG. 7B is a front view of the extension of the drug container of FIG. 7A. [Figure 8A] FIG. 13 is a front view of yet another embodiment of a drug container. [Figure 8B] FIG. 8B is a top perspective view of the spout and extension of the drug container of FIG. 8A. [Figure 8C] FIG. 8B is a right side view of the spout and extension of the drug container of FIG. 8A. [Figure 9A] FIG. 13 is a perspective top view of yet another embodiment of a drug container. [Figure 9B] FIG. 9B is a cross-sectional view of the drug container of FIG. 9A taken along FF. [Figure 9C] FIG. 9B is a cross-sectional view of the drug container of FIG. 9A taken along line GG. [Figure 10] FIG. 13 is a perspective top view of yet another embodiment of a drug container. [Figure 11] FIG. 13 is a front view of yet another embodiment of a drug container. [Figure 12] FIG. 13 is a front view of yet another embodiment of a drug container. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0007] It should be understood that aspects are described herein with reference to some exemplary embodiments and drawings. The exemplary embodiments described herein are not necessarily intended to show all aspects, but are rather used to explain some exemplary embodiments. Thus, the aspects are not intended to be narrowly interpreted in view of the exemplary embodiments. In addition, it should be understood that specific features disclosed herein can be used alone or in any suitable combination with other features.

[0008] The drug container may be arranged to transition from an expanded state in which the container is configured to hold fluid to a collapsed state in which at least a portion of the fluid has been withdrawn from the container, in some embodiments, transition between the two states may be enabled by flexibility of the sidewalls of the container.

[0009] In conventional containers with flexible side walls, the flexible side walls (or portions of the side walls) may sometimes collapse before all of the fluid within the container is completely drawn. When the side walls collapse during the drawing of fluid from these conventional containers, it may be difficult to extract the remaining amount of fluid from the container because the fluid may be trapped between or behind the collapsed portions of the container. Premature or undesired collapse of the side walls may result in waste of the medication or fluid remaining within the container. Thus, the inventors have recognized the need for a technique to aid in emptying flexible wall containers and reduce the likelihood of residual fluid remaining within the container after the side walls have collapsed.

[0010] According to one aspect, the drug container can include an extension that extends into the interior volume of the drug container. In some embodiments, the sidewall of the drug container may at least partially define the interior volume of the drug container. The extension can provide structural support to the sidewall(s) of the drug container to help prevent premature collapse. In one embodiment, the extension is a substantially flat body that extends more than a quarter or more than halfway into the container. The extension can extend from a spout through which fluid can flow into and / or out of the container. In some embodiments, both the spout and the extension can include coaxial passages for directing flow into and / or out of the container. In some embodiments, the extension can include grooves distributed on a surface of the extension, for example, to direct fluid flow into the passages. In some embodiments, the container can include ribs extending from the sidewall to prevent premature collapse of the container and to direct fluid toward the spout in a crushed state.

[0011] In some embodiments, the drug container may be configured and arranged to contain a fluid drug or any other fluid in the expanded state. Exemplary fluid drugs contained in the drug container may include one or more therapeutic agents, such as insulin, insulin analogs such as insulin lispro or insulin glargine, insulin derivatives, GLP-1 receptor agonists such as dulaglutide or liraglutide, glucagon, glucagon analogs, glucagon derivatives, gastric inhibitory polypeptide (GIP), GIP analogs, GIP derivatives, combined GIP / GLP-1 agonists such as tirzepatide, oxyntomodulin analogs, oxyntomodulin derivatives, therapeutic antibodies, etc. The therapeutic agents may be formulated with one or more excipients. As the present disclosure is not limited, in some embodiments, the container may contain another suitable fluid or soft material, such as baby food or confectionery products. The spout may be configured and arranged to be in fluid communication with the volume of the drug container.

[0012] In some embodiments, the drug container includes a sidewall and a spout. The sidewall may be more flexible than the extension such that the drug container has a collapsed state when empty and an expanded state when full.

[0013] In some embodiments, the sidewall comprises a single flexible sheet that is folded or otherwise arranged to form a container capable of containing a fluid in an expanded state, and as the disclosure is not limited thereto, in these embodiments, the peripheral edges of the folded flexible sheet may be joined together using any suitable method, such as heat sealing, welding, or adhesive bonding.

[0014] In some embodiments, the sidewall comprises a plurality of flexible films capable of being reconfigured from an expanded state to a collapsed state while fluid is being extracted from the container through the spout. In some embodiments, the plurality of flexible films are capable of being reconfigured from a collapsed state to an expanded state while fluid is being inserted into the container, for example, through the spout or through a separate inlet. As the disclosure is not limited, in these embodiments, the plurality of flexible films, for example, two flexible films, are joined at the periphery of the container using any suitable method, such as heat sealing, welding, or adhesive bonding. In some embodiments, the sidewall is suitably joined to the spout such that the only outlet for fluid in the container is through the spout. In other words, the sidewall is attached to the spout to prevent fluid transport from the container between the sidewall and the spout. Thus, the extension extends into the container beyond the seam of the periphery of the sidewall. In some embodiments, the extension is substantially inside the interior volume.

[0015] In some embodiments, the spout includes a passageway in fluid communication with the interior volume of the container. In some embodiments, the passageway is a cylindrical opening that extends through a portion of the spout, and the passageway has an interior sidewall that is partially or completely enclosed through the extension. However, in other embodiments, the passageway may be any suitable geometry for fluid communication with the interior volume of the container, as the disclosure is not limited.

[0016] In some embodiments, the drug container further includes an extension coupled to the spout. The extension is disposed within the interior volume of the container. In some embodiments, the extension is configured to prevent the sidewall from prematurely collapsing before the fluid is completely drained from the container. In these embodiments, the extension provides rigid support to opposing sides of the container under crushed or vacuum conditions to keep the sidewalls physically separated. In some embodiments, the physical separation of the sidewalls during emptying allows residual fluid in the container to flow out. In some embodiments, the extension is formed as part of or integral with the spout during the manufacturing process. In other embodiments, the extension is coupled to the spout using any suitable process, including heat sealing, welding, adhesive bonding, or mechanical means, as the present disclosure is not limited.

[0017] In some embodiments, the extension is adequately separated from the sidewall such that there may be fluid flow between the sidewall and the extension. In some embodiments, the extension extends into the interior volume of the container beyond the point where the container is sealed to the spout. In some embodiments, the extension is only connected to the sidewall via the spout in the expanded state of the container.

[0018] In some embodiments, the extension extends substantially into the container. In some embodiments, the extension height measured along the central axis of the passage is greater than one-quarter of the sidewall height measured along the central axis of the passage. In some embodiments, the extension height is greater than half of the sidewall height. In some embodiments, the extension height is less than or equal to one-quarter of the sidewall height, or any other suitable height, as the disclosure is not limited.

[0019] In some embodiments, the shape of the body of the extension provides one or more advantages. For example, in some embodiments, the extension is shaped to help prevent premature collapse of the sidewall under vacuum while minimizing the volume occupied by the extension inside the container, which may reduce the total volume available for fluid. In some embodiments, the extension can include beveled edges and smooth corners. In some embodiments, the smooth corners reduce the possibility of damage to the sidewall when the extension contacts the sidewall. However, it should be understood that other advantages provided by the shape of the extension are possible and the advantages identified above may not necessarily apply, as this aspect is not limiting.

[0020] In some embodiments, the extension includes a first end at the spout and a second end located inside the interior volume of the container distal from the spout. In some embodiments, the cross-sectional area of ​​the extension at the first end taken perpendicular to the central axis of the passageway may be greater than the cross-sectional area of ​​the extension at the second end taken perpendicular to the central axis of the passageway. In some embodiments, the extension is continuously tapered such that the cross-sectional area of ​​the extension along the central axis of the passageway decreases continuously. In other embodiments, the extension includes several portions, and the cross-sectional area of ​​each portion along the central axis of the passageway varies based on the portion. For example, in one embodiment, the extension includes a first portion including the first end and a second portion including the second end. In this embodiment, the cross-sectional area of ​​the first portion is constant along the central axis, while the cross-sectional area of ​​the second portion decreases as it moves distal from the spout along the central axis. It should be understood that in other embodiments, any suitable gradual change in the cross-sectional area of ​​any portion of the extension may be used, as the disclosure is not limited.

[0021] In some embodiments, the cross-sectional shape of the extension is configured to allow the sidewall to conform significantly to the extension when the container is under vacuum. In some embodiments, the extension includes smooth, angled edges. In some embodiments, the cross-sectional shape of the extension does not change along the central axis of the passage, while in other embodiments, the cross-sectional shape of the extension changes along the central axis of the passage. In one embodiment, the cross-sectional shape of the extension is hexagonal at the first end, configured such that a pair of opposing faces are parallel to the sidewall. The remaining four faces are sufficiently angled to allow the sidewall to conform to the extension when the container is under vacuum. In some embodiments, the extension is significantly flat and parallel to the sidewall. For example, in an embodiment where the cross-sectional shape at the first end is hexagonal, the pair of opposing faces parallel to the sidewall are the longest sides of the hexagon. In other embodiments, the cross-sectional shape is elliptical, with the minor axis of the ellipse positioned such that it is perpendicular to the sidewall when the container is in a crushed state. As the present disclosure is not limited, it should be understood that the extension may have any suitable cross-sectional shape, including, but not limited to, a polygonal or lenticular shape.

[0022] In some embodiments, the cross-sectional shape of the extension varies at different portions of the extension. For example, in one embodiment, the extension includes a first portion including a first end and a second portion including a second end. In this example, the cross-sectional shape of the first portion is hexagonal and the cross-sectional shape of the second portion is elliptical. In another example, the cross-sectional shape of the first portion is hexagonal and the cross-sectional shape of the second portion is lenticular, e.g., a pointed elliptical. At the second end, the extension may taper toward the edge. In embodiments where the cross-sectional shapes at the first and second ends are different, the cross-sectional shape of the extension may gradually change from the shape at the first end to the shape at the second end. As the disclosure is not limited, the change in the cross-sectional shape of the extension along the central axis may be linear or non-linear, or a combination of the two. While any portion of the extension may include an abrupt change in either cross-sectional shape or area, in some embodiments, the change in extension geometry may occur smoothly.

[0023] In some embodiments, the extension extends into the container along the central axis of the passage. In other embodiments, the extension is a multi-body extending at various angles to the central axis of the passage, as this disclosure is not limited. In some embodiments, the passage divides the extension into multiple portions. In some cases, this allows for greater outflow of fluid from the spout. In some embodiments, the passage in the extension has a larger cross-sectional area perpendicular to the central axis of the passage in the spout compared to the passage in the spout. As this disclosure is not limited, it should be understood that the extension may be any suitable shape or shapes.

[0024] In some embodiments, the passageway extends directly from the spout to the second end of the extension. In some embodiments, the passageway extends from the spout and is divided into multiple passageways or channels in the extension. The multiple passageways may be arranged at various angles relative to the central axis of the passageway in the spout. The distribution of multiple passageways in the extension can fluidly connect the fluid captured at the edge of the extension with the spout, allowing for more outflow of the fluid from the spout.

[0025] In some embodiments, the extension is solid. In other embodiments, the extension includes an internal architecture. In these embodiments, the extension can reduce the total volume footprint of the extension while still retaining structural rigidity, especially when the container is in a crushed state. In some embodiments, the extension includes one or more grooves on a surface of the extension. In some embodiments, the one or more grooves are angled with respect to the central axis of the passageway. In any embodiment in which the extension includes a groove, the groove may be in fluid communication with the passageway at the spout. In some embodiments, the grooves function as multiple passageways of the extension. As the disclosure is not limited, in some embodiments, the one or more grooves are angled at any angle between 0 and 90 degrees with respect to the central axis of the passageway, for example, 0°, 15°, 30°, 45°, 60°, 75°, or 90°.

[0026] In some embodiments, the geometry of the groove is configured to prevent the sidewall from collapsing within the groove. For example, the groove may be large enough to allow fluid flow into and out of the passageway, but small enough to prevent the sidewall from getting stuck in the groove and impeding the fluid flow. As the disclosure is not limited, the groove may be any suitable shape that allows fluid flow between the container and the passageway, including but not limited to polygonal or elliptical.

[0027] In some embodiments, the drug container includes one or more ribs formed on the sidewall to prevent the sidewall from prematurely collapsing before fluid has been completely expelled from the container. In some embodiments, the ribs project inwardly into the interior volume of the container. In other embodiments, the ribs project outwardly from the interior volume of the container. In some embodiments, a combination of ribs projecting inwardly into the interior volume and ribs projecting outwardly from the interior volume of the container is provided.

[0028] In some embodiments, the ribs are formed on one surface of the sidewall, while in other embodiments, the ribs are formed on two or more surfaces of the sidewall.

[0029] In some embodiments, the ribs and sidewalls are integrally formed as a single component, such that the single component is formed in one piece at the same time using, for example, hot embossing or molding, although any suitable technique may be used to form the ribs.

[0030] In other embodiments, the ribs and the sidewall are formed separately and then attached to one another. In some embodiments, the ribs are attached to an inner surface of the sidewall such that the ribs are inside the interior volume of the container. In some embodiments, the ribs are attached to an outer surface of the sidewall such that the ribs are outside the interior volume of the container.

[0031] As discussed herein, in some embodiments, the ribs protrude outwardly from the interior volume of the container. In some embodiments, the ribs protrude outwardly from the plane of the sidewall when the container is in a crushed state. In some embodiments, the ribs are solid such that the thickness of the ribs may be greater than the thickness of the sidewall. In some embodiments, the outwardly protruding ribs have a protruding shape with an empty void below so that fluid can flow inside the ribs. For example, the protruding ribs may be hollow or may have no filling material below the protruding shape. In one exemplary embodiment, the cross section of the ribs has an arch shape, and since there is no filling material below the arch, the outer surface of the ribs is convex and the inner surface of the ribs is concave. In some embodiments, during emptying of the container, the sidewalls collapse before the outwardly protruding ribs collapse. In these embodiments, the ribs facilitate the flow of fluid through those empty voids. In some embodiments, the empty voids extend from the distal end of the sidewall to the spout. In some embodiments, the empty voids serve to increase the interior volume of the container.

[0032] As discussed herein, in some embodiments, the ribs project inwardly into the interior volume of the container. In some embodiments, the inwardly projecting ribs are solid such that the thickness of the ribs may be greater than the thickness of the sidewall. In some embodiments, the inwardly projecting ribs include an empty void (e.g., hollow). In some embodiments, during emptying of the container, the sidewall collapses before the inwardly projecting ribs collapse. In these embodiments, the inwardly projecting ribs prevent the sidewall from collapsing to allow fluid flow between the inwardly projecting ribs from the distal end of the sidewall to the spout.

[0033] In some embodiments, the ribs have a greater stiffness than the container sidewall. The stiffness of the ribs compared to the container sidewall allows the ribs to provide structural support for the sidewall during emptying. In some embodiments, the ribs have a greater stiffness than the container sidewall due to their greater thickness. As an example, in some embodiments, the ribs are thicker than the sidewall in the normal direction of the sidewall. In some embodiments, the ribs have a greater stiffness than the container sidewall due to their geometric shape. For example, the ribs are formed as corrugated shapes on the surface of the sidewall, which can collapse at a higher vacuum than the sidewall, and remain stiffer than the sidewall at some pressure in the collapsed state. In some embodiments, the ribs have a greater stiffness than the container sidewall due to material properties. For example, the ribs are formed from a material that has a greater stiffness than the material of the sidewall. The ribs may be formed from any material or combination of materials that have suitable mechanical properties compatible with the fluid and the application of the container. In some embodiments, the ribs have a greater stiffness than the container sidewall due to any combination of the factors above.

[0034] In some embodiments, the sidewall includes a first or major rib located at the center of the sidewall. The major rib may be elongated such that its longest dimension spans the height of the container, as described above. The major rib may be disposed at any angle between 0 and 90 degrees relative to the central axis of the passageway in the spout, such as 0°, 15°, 30°, 45°, 60°, 75°, 90°, but in some embodiments, the longest dimension of the major rib is aligned with the central axis of the passageway in the spout.

[0035] In some embodiments, the container includes a secondary rib or a second rib that extends at any angle between 0° and 90° relative to the main rib, for example, 0°, 15°, 30°, 45°, 60°, 75°, 90°. In some embodiments, the secondary rib is smaller than the main rib. In some embodiments, the container includes multiple secondary ribs and one main rib. In an exemplary embodiment, multiple short secondary ribs are distributed radially around the main rib to redirect the flow of fluid along the main rib and then along the passageway. In another exemplary embodiment, multiple short secondary ribs are arranged parallel to each other and perpendicular to multiple main ribs distributed on the sidewall. Of course, any suitable combination of secondary ribs and main ribs may be used, as the present disclosure is not limited.

[0036] Any ribs may have any suitable shape, including but not limited to polygonal or curved, although in some embodiments the ribs may be substantially curved and smooth. The curvature may help prevent fluid pooling adjacent the rib, which may lead to incomplete drainage of the container. In some embodiments, the ribs have a partially elliptical cross-section taken along the longitudinal axis of the rib. Of course, the ribs may have any suitable cross-sectional shape for directing fluid flow in the collapsed state, as the disclosure is not limited.

[0037] In some embodiments, the sidewall includes one or more portions, at least a first portion includes the spout and a second portion includes the distal-most edge of the sidewall relative to the spout. In these embodiments, the one or more ribs extend between the first and second portions. In some embodiments, the longest dimension of the one or more ribs is greater than one-quarter of the sidewall height. In some embodiments, the longest dimension of the one or more ribs is greater than one-third of the sidewall height. In some embodiments, the longest dimension of the one or more ribs is greater than one-half of the sidewall height. In some embodiments, the longest dimension of the one or more ribs is greater than three-quarters of the sidewall height. It should be understood that the longest dimension of the one or more ribs may be any suitable size, as this disclosure is not limited.

[0038] In some embodiments, the container includes both an extension and one or more ribs. In these embodiments, the one or more ribs are distributed on the sidewall offset from the central axis of the passage at the spout. In one example, the container has an extension extending along the central axis of the passage and a pair of ribs located on either side of the extension. In another example, the container has an extension extending along the central axis of the passage and a pair of ribs disposed perpendicular to the central axis of the passage. Of course, any suitable combination of rib positions or shapes may be combined with any suitable shape of the extension, as the present disclosure is not limited.

[0039] As described herein, in some embodiments, the sidewall is constructed from a material that allows the container to reconfigure from an expanded state to a collapsed state while fluid is extracted from the container through the spout, and allows the container to reconfigure from a collapsed state to an expanded state while fluid is inserted into the container through the spout. As the disclosure is not limited, in some embodiments, the sidewall is constructed from one or more layers of polymer, including, but not limited to, polypropylene (PP), polyethylene (PE), ethylene vinyl alcohol (EVOH), polyamide (PA), polychlorotrifluoroethylene (PCTFE), cyclic olefin copolymer (COC), polycarbonate (PC), ethylene vinyl acetate (EVA), polyvinyl chloride (PVC), polyvinylidene chloride (PVDC), polystyrene (PS), polyethylene terephthalate (PET), thermoplastic elastomer (TPE), polymethyl methacrylate (PMMA), or any other suitable polymer.

[0040] As described herein, in some embodiments, the spout or extension is constructed from a material that is less flexible than the sidewall, such that the spout and extension do not move or otherwise reconfigure while fluid is being extracted from or inserted into the container through the spout. As this disclosure is not limited, in some embodiments, the spout is constructed from one or more polymers, including, but not limited to, polypropylene (PP), cyclic olefin copolymer (COC), polymethyl methacrylate (PMMA), copolyester (PCTG), polyethylene terephthalate (PET), polycarbonate (PC), polystyrene (PS), high density polyethylene (HDPE), or any other suitable polymer. In some embodiments, the spout is constructed from a composite material.

[0041] With reference to the drawings, certain non-limiting embodiments are described in further detail. It should be understood that the present disclosure is not limited to only the specific embodiments described herein, and therefore the various systems, components, features, and methods described with respect to these embodiments may be used individually and / or in any desired combination. For example, although all embodiments described herein refer to a pharmaceutical container, the container may be configured to contain any suitable fluid, such as a beverage, as the present disclosure is not limited.

[0042] 1, the drug container 100 includes a sidewall 110 and a spout 120. The sidewall 110 at least partially defines an interior volume V configured to contain a drug or any other fluid when the drug container is in an expanded state. The spout 120 is in fluid communication with the interior volume of the drug container 100.

[0043] 1, the sidewall 110 is constructed from two flexible sheets joined together at their periphery by a seam 112. In other embodiments, the sidewall may be made from a single flexible sheet, or three or more flexible sheets, or any other suitable configuration, folded or otherwise arranged to form a container capable of containing a fluid in an expanded state.

[0044] As this disclosure is not limited, the periphery of the sidewalls may be joined together at seam 112 using any suitable method, such as heat sealing, welding, or adhesive bonding. In some embodiments, the sidewalls are further joined to the spout to prevent fluid transfer from the container between the sidewalls and the spout. As this disclosure is not limited, the sidewalls may be joined to the spout using any suitable method, such as heat sealing, welding, or adhesive bonding.

[0045] The spout 120 illustratively includes a passageway 140 that is fluidly connected to the interior volume of the drug container 100. In the illustrative embodiment shown in Figure 1, the passageway 140 is a cylindrical opening that extends through a completely enclosed portion of the sidewall of the spout.

[0046] The drug container 100 further includes an extension 130 connected to the spout 120. The extension 130 is disposed within the container 100 between the sidewall 110 or sidewalls. As described herein, in some embodiments, the extension 130 is separate from the sidewall 110 such that fluid can exist and flow between the sidewall 110 and the extension 130 when the container 100 is in an expanded state. As shown in FIG. 1, the extension 130 extends into the container 100 beyond the seam 112 around the spout 120. In some embodiments, the extension 130 is substantially inside the interior volume V. In the illustrated embodiment of FIG. 1, the extension 130 extends to a central region of the volume of the container 100 such that its distal end is centered along the width and height of the container 100. In some embodiments, the extension 130 is configured to prevent the sidewall 110 from prematurely collapsing before fluid has been completely drained from the container 100. In these embodiments, extension 130 provides rigid support to opposing sides of container 100 under crushed or vacuum conditions to keep sidewalls 110 physically separated. In some embodiments, physical separation of sidewalls 110 during emptying allows residual fluid within container 100 to escape. As shown in FIG. 1, in some embodiments, extension 130 is formed as part of spout 120 during the manufacturing process. As this disclosure is not limited, in other embodiments, extension 130 is bonded to the spout using any suitable process, including heat sealing, welding, adhesive bonding, or mechanical means.

[0047] As shown in Figures 2 and 3, the extension 130 extends into the interior volume V of the container 100. In some embodiments, the extension height H1 (see Figure 2) measured along the central axis AX of the passageway 140 is at least one-quarter of the sidewall height H2 measured along the central axis AX of the passageway. In an exemplary embodiment, as shown in Figure 2, the extension height H1 is about one-half of the sidewall height H2. In some embodiments, the extension height H1 is greater than one-half of the sidewall height H2. In an exemplary embodiment, as shown in Figure 3, the extension height H1 is about two-thirds of the sidewall height H2. In some embodiments, the extension height H1 is less than one-tenth, one-ninth, one-eighth, one-seventh, one-sixth, one-fifth, one-quarter, two-fifths, one-half, one-third, one-half, three-fifths, three-quarters, or four-fifths of the sidewall height H2. As the disclosure is not limited, in some embodiments, the extension height H1 is at least one-tenth, one-ninth, one-eighth, one-seventh, one-sixth, one-fifth, one-quarter, two-fifths, one-third, one-half, three-fifths, three-quarters, or four-fifths, or any other suitable height, of the sidewall height H2. In some embodiments, the extension height H1 is approximately equal to the sidewall height H2. Combinations of the above ranges are also possible. For example, in some embodiments, the extension height H1 is one-tenth, one-fifth, one-tenth to one-half, one-eighth to three-quarters, one-fifth to four-fifths, one-third to two-thirds, or one-half to four-fifths of the sidewall height H2. As the disclosure is not limited, it should be understood that the extension height H1 may be any suitable height relative to the sidewall height H2.

[0048] In some embodiments, the extension 130 includes smooth corners 130C, as shown in Figure 3. Such a feature can help prevent substantial damage to the container sidewall when the sidewall contacts the extension 130.

[0049] As shown in Figure 4, the extension 130 includes a first end 130A at the spout 120 and a second end 130B located inside the interior volume V of the container 100 distal from the spout 120. As shown in Figures 5A-5B, a first cross-sectional area 135A (see Figure 2) of a first portion 132 of the extension taken perpendicular to the central axis AX of the passageway 140 is greater than a second cross-sectional area 135C (see Figure 2) of a second portion 133 of the extension taken perpendicular to the central axis AX of the passageway 140. In some embodiments, the extension is continuously tapered such that the cross-sectional area of ​​the extension along the central axis of the passageway continuously decreases. For example, in the embodiment shown in Figures 4-5C, intermediate cross-sectional area 135B (Figure 5B) is located between first cross-sectional area 135A (Figure 5A) and second cross-sectional area 135C (Figure 5C), and intermediate cross-sectional area 135B is smaller than first cross-sectional area 135A and larger than second cross-sectional area 135C. In other embodiments, the extension includes several integrated portions or regions, and the cross-sectional area of ​​each portion along central axis AX of passageway 140 varies from region to region. For example, in the embodiment shown in Figure 6A, the extension includes first portion 132 including first end 130A and second portion 133 including second end 130B. In this embodiment, the cross-sectional area of ​​first portion 132 is constant along central axis AX, while the cross-sectional area of ​​second portion 133 decreases distally from spout 120 along central axis AX. It should be understood that any suitable gradation in cross-sectional area of ​​any portion of extension 130 may be used, as this disclosure is not limited thereto.

[0050] In some embodiments, the passageway 140 is formed by a completely enclosed interior sidewall 130E that passes through the extension 130. In these embodiments, the passageway 140 is completely enclosed except for openings at the inlet and outlet ends of the passageway 140. As shown in Figures 5A and 5B, the interior sidewall 130E of the extension 130 completely surrounds the passageway 140. The interior sidewall 130E allows for fluid flow between the interior volume V and the spout 120 for fluid transport in and out of the interior volume V.

[0051] In the exemplary embodiment of Figures 4-5C, the interior sidewall 130E spans at least from the first end 130A to the second end 130B. It should be understood that the interior sidewall 130E may traverse any suitable path through the extension 130 to enable fluid transport from the interior volume V to the spout 120. In some embodiments, the passageway 140 at the first end 130A exhibits similar geometric characteristics (e.g., cross-sectional shape) as the portion of the passageway that extends through the spout 120 to reduce the likelihood of substantial pressure build-up between the extension 130 and the spout 120 during fluid transport.

[0052] In some embodiments, the end of the passageway 140 has an opening 130F that is cut or scored into the extension 130, as shown in FIG. 4. The passageway 140 in FIG. 4 illustratively includes an opening 130F that is cut into the extension 130 in a V-shape such that the second end 130B is bifurcated into two parts. Due to the bifurcated shape, the interior sidewall 130E is only partially enclosed at the second end 130B, as shown in FIGS. 4 and 5C. The opening 130F may extend any suitable distance from the distal end 130B toward the spout 120. It should be understood that any degree of encirclement of the passageway 140 by the interior sidewall 130E may be used, as this disclosure is not limited. The opening of the passageway 140 with the cut opening 130F may allow more fluid flow from the interior volume V into the passageway 140 and to the spout 120. It should be understood that any shape for the opening 130F of the passageway 140 may be used, as this disclosure is not limited.

[0053] 6A, the extension 130 includes edges 131A, 131B spaced apart from the passageway 140. The edges are on either side of the central axis AX, such that the first edge 131A is on one side of the central axis AX and the second edge 131B is on the opposite side of the central axis. Illustratively, a portion of the edges 131A, 131B are angled relative to the central axis AX and a portion of the edges 131A, 131B are parallel to the central axis AX. In particular, as shown in FIG. 6A, the edges 131A, 131B of the first portion 132 are parallel to the central axis AX, and the edges 131A, 131B of the second portion 133 are angled relative to the central axis AX, such that the second portion 133 has a tapered width W1. In some embodiments, the tapered width W1 of the second portion 133 causes the cross-sectional area of ​​the second portion 133 to change along the central axis AX. In other embodiments, the edges of the extension are parallel to the central axis AX along the entire length of the extension. As this disclosure is not limited, it should be understood that any angle between 0° and 90° of the edges 131A, 131B relative to the central axis AX may be used, including, for example, 0°, 15°, 30°, 45°, 60°, 75°, or 90°. In some embodiments, the edges 131A, 131B may be mirrored along the central axis AX (e.g., the extension may be symmetrical about the central axis AX), while in other embodiments, the edges 131A, 131B may be asymmetrical about the central axis AX.

[0054] 1-6B, the extension 130 may be centrally located with respect to the sidewall width W2. In other words, the central axis AX of the container may extend through the length of the extension, illustratively through the center of the extension.

[0055] As shown in FIGS. 1-6B, the extension 130 is centered along the central axis AX. In embodiments where the central axis AX is located halfway across the sidewall width W2, as shown in FIG. 6A, the second end 130B may also be located approximately halfway along the sidewall width W2 and thus aligned along the axis AX. Thus, in some embodiments, the container 100, including the sidewall 110, the spout 120, and the extension 130, may be mirrored with respect to the central axis AX. When the extension 130 is located midway along the sidewall width W2, the edges 131A, 131B are equidistant from the periphery of the sidewall 110. As the disclosure is not limited, in some embodiments, the extension 130 is centered across the sidewall width W2, but the extension 130 may be located anywhere along the sidewall width W2 or may be offset from the axis AX.

[0056] In FIG. 6A, the extension width W1 at the first end 130A is smaller than the sidewall width W2. Illustratively, the extension width W1 is about one-third of the sidewall width W2. In other embodiments, the extension width W1 is about half of the sidewall width W2. In other embodiments, the extension width W1 is at least one-fifth, one-quarter, one-third, two-fifths, one-half, three-fifths, two-thirds, or three-quarters of the sidewall width W2. In some embodiments, the extension width W1 may be less than one-fifth of the sidewall width W2. Combinations of the above ranges are also possible. For example, the extension width W1 may be one-fifth to three-quarters, one-quarter to two-thirds, one-third to two-thirds, one-third to one-half, or one-fifth to three-fifths of the sidewall width W2. It should be understood that the extension width W1 may be any width relative to the sidewall width W2, as the present disclosure is not limited.

[0057] In the exemplary embodiment of FIG. 6A, the extension width W1 is less than the spout width W3. In some embodiments, the extension width W1 at the first end 130A is at least two-thirds of the spout width W3. In some embodiments, the extension width W1 is at least one-fifth, one-quarter, one-third, two-fifths, one-half, three-fifths, two-thirds, or three-quarters of the spout width W3. In some embodiments, the extension width W1 is less than three-quarters, two-thirds, three-fifths, one-half, two-fifths, one-third, one-quarter, or one-fifth of the spout width W3. Combinations of the above ranges are also possible. For example, the extension width W1 may be one-fifth to three-quarters, one-quarter to two-thirds, one-third to two-thirds, one-third to one-half, or one-fifth to three-fifths of the spout width W3. In some embodiments, the extension width W1 is approximately equal to the spout width W3. It should be understood that the extension width W1 may be any width relative to the spout width W3 as this disclosure is not limited.

[0058] In other embodiments, the extension width W1 may be greater than the spout width W3. For example, the spout width W3 may be at least one-fifth, one-quarter, one-third, two-fifths, one-half, three-fifths, two-thirds, or three-quarters of the extension width W1. In some embodiments, the spout width W3 may be less than one-fifth, one-quarter, one-third, two-fifths, one-half, three-fifths, two-thirds, or three-quarters of the extension width W1. Combinations of the above ranges are also possible. For example, the spout width W3 may be one-fifth to three-quarters, one-quarter to two-thirds, one-third to two-thirds, one-third to one-half, or one-fifth to three-fifths of the extension width W1. It should be understood that the spout width W3 may be any width relative to the extension width W1, as the present disclosure is not limited.

[0059] In some embodiments, the change in cross-sectional area of ​​the extension 130 along the central axis AX may be due in whole or in part to a decrease in the thickness of the extension 130 in a direction T perpendicular to the sidewall 110, as shown in FIG. 6B. In the illustrated embodiment, the thickness of the first end 130A is approximately equal to the thickness of the spout 120, and the thickness of the first portion 132 of the extension 130 is greater than the thickness of the second portion 133. In FIG. 6B, the thickness of the first portion 132 is constant along the central axis AX. However, in other embodiments, the thickness of the first portion 132 may decrease in a distal direction of the spout 120 along the central axis AX. In the illustrated embodiment, the thickness of the second portion 133 varies along the central axis AX, specifically, illustratively decreases in a distal direction of the spout 120 along the central axis AX. It should be understood that the thickness profile of the extension 130 may be any suitable shape, as the present disclosure is not limited thereto.

[0060] It should be appreciated that the change in cross-sectional area of ​​extension 130 may be due to any combination of taper width W1 and taper thickness T, as shown in Figures 6A and 6B.

[0061] In the illustrated embodiment, the cross-sectional shape of the extension 130 is configured to allow the sidewall 110 to conform significantly to the extension 130 when the container 100 is crushed or under vacuum. In some embodiments, the cross-sectional shape of the extension 130 may not change along the central axis AX of the passage, while in other embodiments, the cross-sectional shape of the extension 130 may change along the central axis AX of the passage. In one embodiment shown in Figures 5A-5C, the cross-sectional shape 135A of the first portion 132 of the extension 130 is hexagonal and configured such that a pair of opposing faces are parallel to the sidewall 110. The first portion 132 may include a pair of faces 130D (only one face is visible in Figure 5C) that are parallel to the central axis AX. The remaining four faces may be sufficiently angled relative to the parallel faces 130D to allow the sidewall 110 to conform to the extension when the container 100 is under vacuum. In some embodiments, the extension 130 may be substantially flat and parallel to the sidewall 110. For example, in an embodiment in which the cross-sectional shape 135A of the first portion 132 is hexagonal, the pair of faces 130D parallel to the sidewalls are the longest sides of the hexagon, as shown in FIG. 5A. In other embodiments, the cross-sectional shape may be elliptical, with the minor axis of the ellipse oriented so as to be perpendicular to the sidewalls when the container is in a crushed state. As the disclosure is not limited, any cross-sectional shape of the extension may have any suitable shape, including, but not limited to, polygonal or lenticular.

[0062] In some embodiments, the cross-sectional shape of the extension may vary at different portions of the extension 130. For example, in one embodiment shown in Figures 4-6B, the extension 130 includes a first portion 132 including a first end 130A and a second portion 133 including a second end 130B. In this example, the cross-sectional shape 135A of the first portion 132 is hexagonal as shown in Figure 5A, and the cross-sectional shape 135C of the second portion 133 is lenticular, e.g., a pointed elliptical, as shown in Figure 5C. In another example, the cross-sectional shape of the first portion 132 is hexagonal and the cross-sectional shape of the second portion 133 is elliptical. As shown in Figure 4, the extension may taper toward the edge of the second end 130B. In embodiments in which the cross-sectional shapes at the first end 130A and the second end 130B are different, the cross-sectional shape of the extension 130 may gradually transition from the shape at the first end to the shape at the second end, as shown in Figures 5A-5C. As this disclosure is not limited, the change in cross-sectional shape of the extension 130 along the central axis AX may be linear, non-linear, or a combination of the two. The extension 130 may include a step and / or gradual change in cross-sectional area.

[0063] 7A and 7B show another exemplary embodiment of a container 200 having a spout 220 and an extension 230. As shown in FIGS. 7A and 7B, the extension 230 extends into the interior volume V of the container 200 along a central axis AX of a passage 240. The passage 240 may divide the extension 230 into multiple portions. The extension 230 in the embodiment shown in FIG. 7A includes a first half positioned on one side of the central axis AX and a second half positioned on the opposite side of the central axis, each half extending distally from the spout 220 into the container. Illustratively, the passage 240 is not completely enclosed along the height of the extension 230. Rather, the interior sidewall 230E of the extension 230 only partially surrounds the passage 240, and the passage 240 opens into the volume of the container along the height of the extension 230 (FIG. 7A). Thus, the passageway 240 is in fluid communication with the interior volume V at several points along the height of the extension 230. In some embodiments, the open passageway 240 serves to allow greater egress of fluid from the interior through the spout 220. In these embodiments, the passageway 240 in the extension 230 may have a larger cross-sectional area (perpendicular to the central axis AX) than the passageway through the spout 220 due to the partial enclosure of the passageway 240. It should be understood that the passageway 240 may be of any suitable shape or shapes as the disclosure is not limited.

[0064] In the embodiment of Figures 7A and 7B, the extension 230 includes multiple grooves 245A, 245B formed along the height of the extension 230. In this embodiment, the extension 230 reduces the total volume footprint of the extension 230 while still providing structural support to the container sidewall(s) 110 upon crushing. The grooves 245A, 245B are formed in the surface of the extension 230. In some embodiments, the grooves 245A, 245B are in fluid communication with the passageway 240. The grooves 245A, 245B may function as multiple additional passageways of the extension 230 that each flow into the main passageway 240. As this disclosure is not limited, in some embodiments, one or more of grooves 245A, 245B may be at any angle between 0 and 90 degrees relative to the central axis AX of the passage 240, including, for example, 0°, 15°, 30°, 45° (similar to groove 245A in FIG. 7B), 60°, 75°, or 90° (similar to groove 245B in FIG. 7B).

[0065] In some embodiments, the extension height H1 may be less than half the sidewall height. For example, an alternative embodiment of a drug container 300, spout 320, and extension 330 is shown in Figures 8A-8C in which the extension has a reduced height, thereby increasing the available space within the interior volume V of the drug container 300 for fluid containment. The reduced height extension provides rigid support for the opposing surface of the container when in a collapsed state or under vacuum, as previously described for other embodiments of the extension.

[0066] The height of the extension in FIG. 8A-FIG. 8C is less than one-quarter of the sidewall height H2. In particular, the extension height H1 in FIG. 8A is about one-tenth of the sidewall height H2. In other embodiments, the extension height H1 may be less than two-fifths, one-third, one-quarter, one-fifth, one-sixth, one-seventh, one-eighth, one-ninth, or one-tenth of the sidewall height H2. Combinations of the above ranges are also possible. For example, the extension height H1 may be one-tenth to three-quarters, one-eighth to two-thirds, one-third to two-thirds, one-third to one-half, or one-fifth to three-fifths of the sidewall height H2. It should be understood that the extension height H1 may be any width relative to the sidewall height H2, as the present disclosure is not limited.

[0067] As shown in FIG. 8A, in some embodiments, the extension height H1 may be less than the extension width W1. In some embodiments, the extension height H1 may be at least one-tenth, one-ninth, one-eighth, one-seventh, one-sixth, one-fifth, one-quarter, one-third, two-fifths, one-half, one-fifth, two-thirds, or three-quarters of the extension width W1. In some embodiments, the extension height H1 may be less than three-quarters, two-thirds, three-fifths, one-half, two-fifths, one-third, one-quarter, one-fifth, one-sixth, one-seventh, one-eighth, one-ninth, or one-tenth of the extension width W1. Combinations of the above ranges are also possible. For example, the extension height H1 may be one-tenth to three-quarters, one-eighth to two-thirds, one-third to two-thirds, one-third to one-half, or one-fifth to three-fifths of the extension width W1. It should be understood that the extension height H1 may be any width relative to the extension width W1, as this disclosure is not limited.

[0068] In other embodiments, the extension height H1 may be approximately equal to the extension width W1. In yet other embodiments, the extension height H1 may be greater than the extension width W1, as shown in Figures 1-7B. In some embodiments, the extension width W1 may be at least one-tenth, one-ninth, one-eighth, one-seventh, one-sixth, one-fifth, one-quarter, one-third, two-fifths, one-half, one-fifth, two-thirds, or three-quarters of the extension height H1. In some embodiments, the extension width W1 may be less than three-quarters, two-thirds, three-fifths, one-half, two-fifths, one-third, one-quarter, one-fifth, one-sixth, one-seventh, one-eighth, one-ninth, or one-tenth of the extension height H1. Combinations of the above ranges are also possible. For example, extension width W1 may be one-tenth to three-quarters, one-eighth to two-thirds, one-third to two-thirds, one-third to one-half, or one-fifth to three-fifths of extension width H1. In some embodiments, extension width W1 is one-third of extension height H1. It should be understood that extension height H1 may be any width relative to extension width W1, as the present disclosure is not limited.

[0069] 8A-8C, the extension 330 includes edges 331A, 331B spaced apart from the passageway 340. The edges are on either side of the central axis AX such that the first edge 331A is on one side of the central axis AX and the second edge 331B is on the opposite side of the central axis. In some embodiments, a substantial portion of the edges 331A, 331B may be angled relative to the central axis AX, as shown in FIG. 8A. In other embodiments, as previously discussed, portions of the edges 331A, 331B may be angled relative to the central axis AX, and portions of the edges 331A, 331B may be parallel to the central axis AX or at a different angle. Any angled portions of the edges 331A, 331B may be angled relative to the central axis AX such that the extension 330 has a tapered width W1. It should be understood that any angle between 0° and 90° of the edges 331A, 331B relative to the central axis AX may be used, including, for example, 0°, 15°, 30°, 45°, 60°, 75°, or 90°, as this disclosure is not limited. In some embodiments, the edges 331A, 331B may be mirrored across the central axis AX (e.g., the extensions may be symmetric about the central axis AX), while in other embodiments, the edges 331A, 331B may not be mirrored across the central axis AX (e.g., the extensions may be asymmetric about the central axis AX).

[0070] As shown in Figure 8B, the extension 330 includes a pair of opposing curved surfaces 336 extending from the spout 320. In the embodiment shown in Figure 8B, the curved surfaces 336 of the extension 330 include a concave surface at a first end 330A to generally match the shape of the spout 320. The extension 330 includes a generally cylindrical interior sidewall 330E that forms a passageway 340.

[0071] The extension 330 also includes a pair of opposing flat surfaces 337, as shown in Figures 8B and 8C. In some embodiments, the flat surfaces 337 may extend from the first end 330A to the second end 330B of the extension 330, while in other embodiments, the flat surfaces 337 may extend only partially between the first end 330A and the second end 330B.

[0072] In some embodiments, the extension 330 may have a thickness T that decreases in a direction away from the spout 320 along the central axis AX, as shown in the side view of FIG. 8C. In some embodiments, the thickness of the first end 330A may be approximately equal to the thickness of the spout 320. In some embodiments, the thickness of the second end 330B may be equal to or less than the thickness of the first end 330A. In some embodiments, the thickness T of the portion of the extension 330 may decrease linearly along the central axis AX, forming a tapered end. As an example, in some embodiments, the extension 330 may include a flat surface 337 as described above, where the flat surface 337 is angled with respect to the central axis AX to form a linearly decreasing thickness. For example, the flat surface 337 may be angled at an angle EA with respect to the central axis AX, as shown in FIG. 8C, where the angle EA may be any angle between 0° and 90°, including, for example, 0°, 15°, 30°, 45°, 60°, 75°, or 90°.

[0073] In other embodiments, the thickness T of the portion of extension 330 may decrease non-linearly along the central axis AX. In yet other embodiments, the thickness T of extension 330 may remain constant throughout extension 330. For example, planes 337 may be parallel to the central axis AX and may be parallel to each other.

[0074] In some embodiments, the thickness T of the extension 330 may vary both linearly and non-linearly along the central axis AX. In some embodiments, the thickness of the extension 330 may decrease along the central axis AX such that the second end 330B is an edge, as shown in FIG. 8C. In these embodiments, the opposing surfaces of the sidewall 310 may contact each other near the second end 330B during emptying of the container 300.

[0075] In some embodiments, any combination of flat surfaces 337 or curved surfaces 336 may include radial, chamfered, or any other smooth corners to prevent damage to sidewall 310 when extension 330 contacts sidewall 310.

[0076] In some embodiments, the extension 330 may be symmetric about the central axis AX. In other embodiments, the extension 330 may be asymmetric about the central axis AX. In embodiments where the extension 330 is asymmetric about the central axis AX, there may be two separate extension angles that define an angle between the central axis AX and the opposing faces of the extension 330. As the disclosure is not limited, it should be understood that in these embodiments, any face of the extension 330 relative to the central axis AX may be angled any angle between 0 and 90 degrees, including, for example, 0 degrees, 15 degrees, 30 degrees, 45 degrees, 60 degrees, 75 degrees, or 90 degrees. As shown in FIG. 8C, the second end 330B may be smooth for manufacturing or operational purposes.

[0077] 8A and 8B, the passageway 340 may have an opening 330F cut or cut into the extension 330. For example, the opening 330F may be an inverted U-shape. The widening of the passageway 340 by the opening 330F may allow for more fluid flow from the interior volume V to the spout 120, as previously described. It should be understood that any shape for the opening 330F or interior sidewall 330E of the passageway 340 may be used, as this disclosure is not limited. It should be understood that any degree of encirclement of the passageway 340 by the extension 330 may be used, as this disclosure is not limited.

[0078] In some embodiments, the drug container includes one or more ribs that reduce the likelihood of premature collapse of the container sidewall before the container is emptied. The ribs can provide rigid support to opposing sides of the container 100 under crushed or vacuum conditions to keep the sidewalls physically separated until the container is emptied. In some embodiments, the physical separation of the sidewall and the ribs during emptying can allow residual fluid in the container to escape. In some embodiments, the ribs can be distributed at various locations around the container. In some embodiments, the ribs can be located distal to the spout so that premature collapse of the container prior to the escape of residual fluid is reduced. In some embodiments, the ribs can be formed to direct residual fluid flow from a distal location in the interior volume V toward the spout.

[0079] For example, in the exemplary embodiment shown in FIG. 9A, the drug container 400 includes one or more major ribs 415A formed on the sidewall 410. In some embodiments, the major ribs 415A project into the interior volume of the container 400. In other embodiments, the major ribs 415A project from the container 400. In some embodiments, a combination of major ribs 415A projecting into and out of the container may be used. In some embodiments, the major ribs 415A may be formed on one surface of the sidewall 410. The major ribs 415A may be formed as part of or integral with the sidewall 410, for example, using hot embossing or molding means, although any suitable technique may be used to form the major ribs 415A.

[0080] In some embodiments, the sidewall 410 can include at least a major rib 410 located at the center of the sidewall 415A. The major rib 415A can be elongated such that its longest dimension spans the container height, as described above and shown in FIG. 9A. The major rib 415A can be disposed at any angle between 0 and 90 degrees, such as 0, 15, 30, 45, 60, 75, or 90 degrees, relative to the central axis AX of the passageway in the spout 420, but in some embodiments, the longest dimension of the major rib 415A can be aligned with the central axis AX of the passageway in the spout 420.

[0081] In some embodiments, the container 400 may include at least one auxiliary or second rib 415B arranged at an angle between 0 and 90 degrees relative to the main rib 415A, such as 0°, 15°, 30°, 45°, 60°, 75°, or 90° (as shown in FIG. 10). In some embodiments, the auxiliary rib 415B is smaller than the main rib 415A. In some embodiments, the container 400 may include multiple auxiliary ribs 415B and multiple main ribs 415A. In the exemplary embodiment shown in FIG. 10, multiple short auxiliary ribs 415B are arranged parallel to each other and perpendicular to multiple main ribs 415A distributed on the sidewall 410. Of course, any suitable combination of auxiliary ribs 415B and main ribs 415A may be used, as the present disclosure is not limited.

[0082] In some embodiments, the primary ribs 415A or the secondary ribs 415B may protrude either into or out of the interior volume of the vessel 400. As described herein, in some embodiments, the primary ribs 415A or the secondary ribs 415B may be hollow such that the ribs protruding from the vessel 400 allow for fluid flow through the ribs 415A, 415B.

[0083] The ribs may have any suitable shape, including but not limited to polygonal or curved, although in some embodiments the ribs are substantially curved and smooth. In some embodiments, the primary rib 415A or secondary rib 415B may have a partially elliptical cross-section along its longitudinal axis (e.g., its longest dimension), as seen in FIG. 9B. In some embodiments, the rib may have a semicircular cross-section along its lateral dimension, as seen in FIG. 9C. Of course, the ribs 415A, 415B may have any suitable cross-sectional shape for directing fluid flow in the collapsed state, as this disclosure is not limited.

[0084] In some embodiments, the container 400 may include one or more portions or regions including at least a first portion 450 including the spout 420 and a second portion 460 including the distal-most edge of the sidewall 410 away from the spout 420. In these embodiments, one or more ribs 415A may span between the first and second portions. In some embodiments, the longest dimension H3 of the one or more ribs may be greater than one-quarter of the sidewall height H2. In some embodiments, the longest dimension H3 of the one or more ribs may be greater than one-third of the sidewall height H2. In some embodiments, the longest dimension H3 of the one or more ribs may be greater than one-half of the sidewall height H2. In some embodiments, the longest dimension H3 of the one or more ribs may be greater than three-quarters of the sidewall height H2. As the disclosure is not limited, in any embodiment, the longest dimension of the one or more ribs H3 may be any suitable size.

[0085] As shown in FIG. 11, in some embodiments, the container 500 may include both an extension 530 and one or more primary ribs 515A. In these embodiments, the one or more primary ribs 515A may be positioned on the sidewall 510 offset from the central axis AX of the passage at the spout 520. In one example, the container 500 has an extension 530 extending in a direction along the central axis AX and a pair of primary ribs 515A located on either side of the extension 530, the primary ribs 515A extending in a direction parallel to the central axis AX. In another example, as shown in FIG. 12, the container 500 has an extension 530 extending in a direction along the central axis AX and a pair of secondary ribs 515B extending in a direction perpendicular to the central axis AX of the passage. In another example, the ribs may be angled toward the entrance of the passage at the extension 530 to direct the flow of fluid into the passage. Of course, any suitable combination of rib positions or shapes may be combined with any suitable shape of the extension, as this disclosure is not limited.

[0086] Various aspects of the disclosure may be used alone, in combination, or in various arrangements not specifically described in the foregoing embodiments, and therefore are not limited in their application to the details and arrangements of components set forth in the foregoing description or illustrated in the drawings. For example, aspects described in one embodiment may be combined in any manner with aspects described in other embodiments.

[0087] Although the present teachings have been described in conjunction with various embodiments and examples, it is not intended that the present teachings be limited to such embodiments or examples. On the contrary, the teachings of the present invention encompass various alternatives, modifications, and equivalents, as will be understood by those skilled in the art. Therefore, it should also be understood that the invention of the present disclosure is not limited to any particular embodiment having any particular feature, and that features described herein as part of one or more embodiments may be combined with or removed from other embodiments. Therefore, the foregoing description and drawings are by way of example only.

Claims

1. A pharmaceutical container comprising: a sidewall at least partially defining an interior volume of the medicament container; a spout coupled to the side wall for pouring a medicament from the interior volume of the medicament container; an extension coupled to the spout, the extension having a pair of opposing surfaces, the extension being disposed inside the interior volume of the medicament container and including a passageway in fluid communication with the interior volume of the medicament container and the spout, the sidewall having a greater flexibility than the extension such that the medicament container has a collapsed state when empty and an expanded state when full; the sidewall is configured to move as medicament flows out of the interior volume of the medicament container through the spout; the extension has a first end adjacent the spout and a second end opposite the first end, the pair of opposing faces of the extension tapering toward an edge at the second end; The edge extends between a pair of corners of the extension at the second end, a height of the extension measured from the first end to the second end along a central axis of the spout is at least one-quarter of a sidewall height, the sidewall height being measured along a dimension parallel to the central axis of the spout when the drug container is in the expanded state.

2. The extension extends centrally along the central axis of the spout; The drug container of claim 1 , wherein the pair of opposing surfaces are parallel to the side walls when the container is in a crushed state.

3. The extension portion has a cross section, 2. The drug container of claim 1, wherein the cross-sectional dimension parallel to the side wall is greater than the cross-sectional dimension perpendicular to the side wall when the container is in a collapsed state.

4. 2. The drug container of claim 1, wherein the passageway extends through the extension from the second end to the first end and has a scored or cut opening at the second end.

5. 10. The drug container of claim 1, wherein the passageway has a completely enclosed interior sidewall.

6. 6. The drug container of claim 5, wherein the interior sidewall includes at least one opening disposed between the first end and the second end of the extension, the interior sidewall being in fluid communication with the interior volume of the drug container through the at least one opening.

7. A drug container as described in claim 1, wherein the edges and corners of the extension are smooth.

8. The medicament container of any one of claims 1 to 7, wherein the side wall of the medicament container comprises a first rib that projects into the interior volume of the medicament container.

9. The drug container of any one of claims 1 to 7, wherein the side wall of the drug container comprises a first rib protruding from the drug container.

10. 9. The drug container of claim 8, wherein the first rib extends parallel to a direction of flow through the spout.

11. The drug container according to claim 8, further comprising a second rib, the second rib extending in a direction at an angle of 0 degrees to 90 degrees with respect to an extension direction of the first rib.

12. 9. The drug container of claim 8, wherein a cross-section of the first rib taken along a longitudinal axis of the first rib is elliptical.

13. A pharmaceutical container comprising: a sidewall at least partially defining an interior volume of the medicament container; a spout coupled to the side wall for pouring a medicament from the interior volume of the medicament container; an extension coupled to the spout, the extension being disposed inside the interior volume of the medicament container and including a passageway in fluid communication with the interior volume of the medicament container and the spout, the sidewall having a greater flexibility than the extension such that the medicament container has a collapsed state when empty and an expanded state when full; the sidewall is configured to move as medicament flows out of the interior volume of the medicament container through the spout; the extension comprises a first portion having a first end and a second portion having a second end, the first end being closer to the spout than the second end, and the passageway having an opening at the second end; a cross-sectional area of ​​the extension measured perpendicular to a central axis of the spout is greater at the first portion than at the second portion, the cross-sectional area of ​​the first portion being constant and the cross-sectional area of ​​the second portion decreasing away from the spout along the central axis such that the extension tapers towards the second end, the central axis being parallel to a direction of flow through the spout; the extension has a first edge and a second edge, each edge being away from the passageway, the first edge being disposed on one side of the central axis and the second edge being disposed on an opposite side of the central axis, the first edge and the second edge extending continuously along the first and second portions of the extension.

14. 14. The drug container of claim 13, wherein a height of the extension measured along the central axis of the spout is at least one-quarter of a sidewall height, the sidewall height being measured along a dimension parallel to the central axis of the spout when the drug container is in the expanded state.

15. 14. The drug container of claim 13, wherein the extension extends centrally along the central axis of the spout.

16. 14. The drug container of claim 13, wherein the cross-sectional area of ​​the second portion of the extension decreases continuously such that the extension tapers toward an edge at the second end of the extension.

17. 14. The drug container of claim 13, wherein a cross-sectional area of ​​the second portion of the extension tapers in width and thickness toward the second end of the extension.

18. 14. The drug container of claim 13, wherein a cross section of the extension perpendicular to the central axis of the spout is hexagonal at the first end.

19. 14. The drug container of claim 13, wherein a cross-section of the extension perpendicular to the central axis of the spout is lenticular adjacent the second end.

20. The drug container of claim 13, wherein the first edge and the second edge of the first portion of the extension are parallel to the central axis of the spout.

21. The drug container of claim 13, wherein the first edge and the second edge of the second portion of the extension are angled at an angle of 15 to 75 degrees relative to the central axis of the spout such that the second portion has a tapered width.

22. A medicament container according to any one of claims 13 to 21, wherein the side wall of the medicament container comprises a first rib that projects into the interior volume of the medicament container.

23. A medicament container according to any one of claims 13 to 21, wherein the side wall of the medicament container comprises a first rib protruding from the medicament container.

24. 23. The drug container of claim 22, wherein the first rib extends parallel to a direction of flow through the spout.

25. The drug container of claim 22, further comprising a second rib, the second rib extending in a direction at an angle of 0 degrees to 90 degrees with respect to an extension direction of the first rib.

26. 23. The drug container of claim 22, wherein a cross-section of the first rib taken along a longitudinal axis of the first rib is elliptical.

27. 14. The drug container of claim 13, wherein the opening of the passageway at the second end of the extension is scored or cut into the extension.

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