Sterilization / virus inactivation composition

Abstract

To provide a microbicidal and virus-inactivating composition which exhibits excellent microbicidal effect and excellent virus-inactivating effect, e.g., a microbicidal and virus-inactivating composition containing no lower alcohol or a low concentration of lower alcohol which exhibits excellent microbicidal effect and excellent virus-inactivating effect while sufficiently preventing impacts on the appearance of a specific washed object.SOLUTION: A microbicidal and virus-inactivating composition comprises an amine compound with an acid dissociation constant (pKa) of 9.0 or more, and a cationic surfactant.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a bactericidal / virus inactivating composition.

Background Art

[0002] Bacteria such as Staphylococcus aureus and Salmonella are known as causative bacteria of food poisoning. To prevent food poisoning caused by these bacteria, it has been conventionally practiced to sterilize these bacteria using a bactericidal composition such as a lower alcohol or a quaternary ammonium compound.

[0003] In recent years, the occurrence of infectious gastroenteritis or food poisoning caused by viruses such as norovirus has been frequent throughout the year, especially from November to March being the peak of occurrence. In particular, norovirus is an RNA virus without an envelope classified in the family Caliciviridae, genus Norovirus (hereinafter referred to as "norovirus etc."), and has strong resistance to alcohol (ethanol, isopropanol, etc.), heat, acid (gastric acid, etc.), or drying, etc. The incubation period is considered to be 1 to 2 days, and the main symptoms of nausea, vomiting, and diarrhea appear, but it may also be accompanied by abdominal pain, headache, fever, chills, muscle pain, sore throat, fatigue, etc.

[0004] Furthermore, the novel coronavirus infection has occurred in 2020. In order to prevent droplet infection, for example, in stores such as supermarkets, department stores, and restaurants, accommodation facilities, medical facilities, offices, etc., acrylic plates or plastic curtains are installed at cash registers, reception counters, interview counters, windows, etc., and acrylic partitions are installed on tables such as at the counter seats of restaurants and on desks in offices, etc. are increasing.

[0005] As a composition for preventing food poisoning caused by bacteria and viruses, Patent Document 1 discloses a composition containing 40 to 95 wt% of a lower alcohol, 0.01 to 5 wt% of an alkaline substance, and 0.01 to 10 wt% of a cationic surfactant.

Prior Art Documents

Patent Document

[0006]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0007] Under the above circumstances, there is a demand for a composition that exhibits excellent bactericidal and virus-inactivating effects. Here, cationic surfactants can exert bactericidal and enveloped virus-inactivating effects, but they do not have a non-enveloped virus-inactivating effect alone. To inactivate non-enveloped viruses, only sodium hypochlorite, povidone iodine, and some alcohol preparations are currently considered effective means. Increasing the variations of compositions suitably used for such bactericidal and virus-inactivating applications can expand the range of choices when using the composition in various modes for such applications, and has great technical significance. Note that sodium hypochlorite has strong oxidizing power and may have an unfavorable effect on objects to be used such as metals and fibers (objects to be washed). Povidone iodine may also have an unfavorable effect on objects to be washed made of metal. In addition, the composition described in Cited Document 1 contains a high concentration of lower alcohol as an essential component together with an alkaline substance and a cationic surfactant. When such an alcohol preparation is used for an object to be washed made of, for example, plastic, it may damage the object to be washed and impair its appearance.

[0008] The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a bactericidal and virus-inactivating composition that exhibits excellent bactericidal effects and excellent virus-inactivating effects, and that, for example, when the lower alcohol is at a low concentration or not blended, sufficiently prevents the influence on the appearance of specific objects to be washed while exhibiting excellent bactericidal effects and excellent virus-inactivating effects.

Means for Solving the Problems

[0009] That is, the bactericidal and virus-inactivating composition of the present invention is characterized by containing an amine compound having an acid dissociation constant (pKa) of 9.0 or more and a cationic surfactant.

[0010] In the present specification, the "bactericidal and virus-inactivating composition" means a composition used for sterilizing at least one kind of bacterium and / or inactivating at least one kind of virus. For example, when the composition is used for disinfecting an acrylic plate or a plastic curtain for preventing droplet infection, or a toilet bowl, a toilet seat, a floor, a wall, etc. in a toilet, it can be said that the composition is used as a bactericidal and virus-inactivating composition.

[0011] The bactericidal and virus-inactivating composition of the present invention contains an amine compound having an acid dissociation constant (pKa) of 9.0 or more. When such an amine compound is combined with a cationic surfactant, the bactericidal effect and the virus-inactivating effect of the cationic surfactant can be improved. As a result, the bactericidal and virus-inactivating composition of the present invention exhibits an excellent bactericidal effect and an excellent virus-inactivating effect. As described above, the cationic surfactant can exhibit a bactericidal effect and an envelope virus-inactivating effect, but has no non-envelope virus-inactivating effect alone. On the other hand, the bactericidal and virus-inactivating composition of the present invention exhibits a high virus-inactivating effect against norovirus, a non-envelope virus, due to the synergistic effect of a specific amine compound and a cationic surfactant. Examples of the "amine compound" include primary amines, secondary amines, and tertiary amines. The pKa of the amine compound in the present specification means the pKa of the amino group of the amine compound in water at 25°C. An amino group is a monovalent functional group in the form of removing hydrogen from ammonia, a primary amine, or a secondary amine. In addition, with respect to an amine compound having an acid dissociation constant (pKa) of 9.0 or higher, when the amine compound has a plurality of amino groups and there are a plurality of pKa values, the highest pKa can be used as a reference, and it is sufficient that the highest pKa is 9.0 or higher. However, it is preferable that the pKa of all amino groups in the amine compound is 9.0 or higher.

[0012] In the sterilizing / virus inactivating composition of the present invention, the above amine compound is preferably at least one selected from the group consisting of aminoethanol, aminopropanol, aminobutanol, methylethanolamine, ethyethanolamine, butylethanolamine, methylpropanolamine, ethylpropanolamine, dimethylaminoethanol, diethylaminoethanol, ethylmethylaminoethanol, dimethylaminopropanol, diethylaminopropanol, aminomethylpropanol, aminoethylpropanol, aminopropylpropanol, aminobutylpropanol, ethylenediamine, diethylenetriamine, triethylenetetramine, piperidine, pyrrolidine, piperazine, benzylamine, aminomethylbenzylamine, aminoethylbenzylamine, and aminoethoxybenzylamine. These amine compounds have high volatility and are unlikely to leave components after use. Thereby, it is possible to sufficiently prevent a problem that the amine compound stays on the surface of an object to be washed, such as an acrylic plate or a toilet seat, for a long time and damages the object to be washed, impairing the appearance of the object to be washed. In addition, it is possible to sufficiently prevent a problem that the amine compound stays on the surface of the object to be washed for a long time and becomes likely to come into contact with human skin, causing roughness of human skin. Furthermore, these amine compounds can enhance the sterilizing effect and virus inactivating effect of the sterilizing / virus inactivating composition of the present invention.

[0013] In the sterilizing / virus inactivating composition of the present invention, the above amine compound preferably has a vapor pressure of 50 Pa or higher. When the vapor pressure of the amine compound is 50 Pa or more, its volatility is high, so after use, it is difficult for the amine compound to remain on the surface of the object to be washed such as an acrylic plate or a toilet seat. As a result, as described above, the influence on the appearance of the object to be washed can be further prevented. Also, even if it adheres to human skin, it is considered difficult to damage human skin. For example, when the bactericidal and virus-inactivating composition of the present invention is used for a toilet bowl or a toilet seat, it is possible to prevent cracks from occurring in the toilet seat or the like, prevent the influence on the appearance, and the bactericidal and virus-inactivating composition of the present invention remains on the toilet bowl or the toilet seat. Even if the bactericidal and virus-inactivating composition of the present invention adheres to the skin of the person who uses the toilet next, it is difficult to damage the skin of that person. In addition, the vapor pressure of the amine compound in this specification means the vapor pressure at 20°C. Also, in this specification, "vapor pressure" means the value according to the Antoine equation.

[0014] In the bactericidal and virus-inactivating composition of the present invention, the cationic surfactant is preferably a quaternary ammonium compound. Since the cationic surfactant is a quaternary ammonium compound, the bactericidal effect and virus-inactivating effect of the bactericidal and virus-inactivating composition of the present invention can be made higher.

[0015] In the bactericidal and virus-inactivating composition of the present invention, the cationic surfactant preferably contains at least one selected from the group consisting of tetraalkylammonium salts, didecylmethylpolyoxyethylammonium salts, alkylbenzyldimethylammonium salts, cetylpyridinium salts, benzethonium salts, alkyldimethylhydroxyethylammonium salts, and polyhexamethylenebiguanide hydrochloride. The counter ion of the cationic surfactant is not particularly limited, and examples thereof include chloride ions, methyl sulfate ions, carbonate ions, adipate ions, and the like. In the tetraalkylammonium salt, the alkyl groups may be the same or different from each other. Examples of those that are different include didecyldimethylammonium salts, dioctyldimethylammonium salts, didodecyldimethylammonium salts, octyldecyldimethylammonium salts, and the like. These cationic surfactants can exhibit a more excellent bactericidal effect and an excellent virus inactivation effect in the bactericidal and virus-inactivating composition of the present invention.

[0016] In the bactericidal and virus-inactivating composition of the present invention, the total concentration of the anionic surfactant, nonionic surfactant, and zwitterionic surfactant is preferably 2% by mass or less. Thereby, the bactericidal effect and virus inactivation effect of the present invention become more remarkable. Note that the total concentration of the anionic surfactant, nonionic surfactant, and zwitterionic surfactant being 2% by mass or less means that the bactericidal and virus-inactivating composition of the present invention does not contain any of the anionic surfactant, nonionic surfactant, and zwitterionic surfactant, and the total concentration of the anionic surfactant, nonionic surfactant, and zwitterionic surfactant may be 0% by mass.

[0017] In the bactericidal and virus-inactivating composition of the present invention, the pH is preferably 9.0 to 13.0. The bactericidal and virus-inactivating composition of the present invention can exhibit an excellent bactericidal effect and an excellent virus inactivation effect in the weakly alkaline range. In this specification, the pH is a value measured by a method according to JIS Z-8802:2011 "pH Measurement Method" at 25°C using a pH meter F-53 (manufactured by Horiba, Ltd.). Note that the pH can be adjusted by controlling the amounts of additives such as acid agents and alkali agents.

[0018] In the bactericidal and virus-inactivating composition of the present invention, the concentration of the lower alcohol is preferably 20% by mass or less. When the concentration of the lower alcohol is 20% by mass or less, the influence on the resin is particularly small, and it is possible to sufficiently prevent damage to objects to be washed made of plastic, toilet bowls, toilet seats, floors, walls, etc., which are the objects of use, and deterioration of characteristics such as their appearance. In this specification, the lower alcohol refers to an alcohol having 5 or less carbon atoms. The valence of the alcohol is not particularly limited. When a plurality of types of lower alcohols are used, the concentration of the lower alcohol is the total concentration of the plurality of types of lower alcohols. Note that the statement that the concentration of the lower alcohol is 20% by mass or less means that the bactericidal / virus inactivating composition of the present invention may not contain the lower alcohol, and the concentration of the lower alcohol may be 0% by mass.

[0019] The bactericidal / virus inactivating composition of the present invention is preferably a norovirus inactivating composition. The bactericidal / virus inactivating composition of the present invention exhibits a high virus inactivating effect against norovirus. In this specification, the "norovirus inactivating composition" means a virus inactivating composition used against at least one virus selected from the group consisting of feline calicivirus, murine norovirus, and human norovirus. Note that the bactericidal / virus inactivating composition of the present invention also exhibits a high virus inactivating effect against influenza virus and coronavirus, which have lower drug resistance than norovirus.

[0020] The bactericidal / virus inactivating composition of the present invention is preferably used on the surface of a hard material. The hard material is not particularly limited, and examples thereof include resins such as metals, ceramics, plastics, glass, and surface-treated wood.

[0021] The present invention is also a sanitary material characterized by containing the bactericidal / virus inactivating composition of the present invention. The sanitary material of the present invention is characterized by containing the bactericidal / virus inactivating composition of the present invention. Since the bactericidal and virus-inactivating composition of the present invention can fully exhibit bactericidal and virus-inactivating effects, by using hygiene materials containing such a bactericidal and virus-inactivating composition, bacterial infections and virus infections can be fully prevented.

Effects of the Invention

[0022] The bactericidal and virus-inactivating composition of the present invention exhibits excellent bactericidal effects and excellent virus-inactivating effects. For example, when the concentration of a lower alcohol is low or not blended, it exhibits excellent bactericidal effects and excellent virus-inactivating effects while sufficiently preventing the influence on the appearance of specific objects to be washed.

Modes for Carrying Out the Invention

[0023] Hereinafter, the bactericidal and virus-inactivating composition of the present invention will be described while showing specific embodiments. However, the present invention is not limited to the following embodiments, and can be appropriately modified and applied within the scope of not changing the gist of the present invention.

[0024] The bactericidal and virus-inactivating composition of the present invention is characterized by containing an amine compound having an acid dissociation constant (pKa) of 9.0 or more and a cationic surfactant. Each component of the bactericidal and virus-inactivating composition of the present invention will be described below.

[0025] (Amine Compound) In the bactericidal and virus-inactivating composition of the present invention, the pKa of the amine compound is 9.0 or more. Further, the pKa of the amine compound is preferably 9.15 or more, and more preferably 9.3 or more. When the pKa of the amine compound is 9.0 or more, the amine compound can improve the bactericidal effect and virus-inactivating effect of the cationic surfactant by being combined with the cationic surfactant. The upper limit value of the pKa of the amine compound is not particularly limited, but is usually 14.0 or less.

[0026] In the sterilizing / virus inactivating composition of the present invention, the amine compound preferably has a vapor pressure of 50 Pa or more, more preferably 60 Pa or more, still more preferably 90 Pa or more, and particularly preferably 100 Pa or more. When the vapor pressure of the amine compound is 50 Pa or more, its volatility is high, so it is difficult for the components to remain after use. The upper limit of the vapor pressure of the amine compound is not particularly limited, but is usually 50,000 Pa or less.

[0027] In the sterilizing / virus inactivating composition of the present invention, the amine compound is preferably at least one selected from the group consisting of aminoethanol, aminopropanol, aminobutanol, methylethanolamine, ethylethanolamine, butylethanolamine, methylpropanolamine, ethylpropanolamine, dimethylaminoethanol, diethylaminoethanol, ethylmethylaminoethanol, dimethylaminopropanol, diethylaminopropanol, aminomethylpropanol, aminoethylpropanol, aminopropylpropanol, aminobutylpropanol, ethylenediamine, diethylenetriamine, triethylenetetramine, piperidine, pyrrolidine, piperazine, benzylamine, aminomethylbenzylamine, aminoethylbenzylamine, and aminoethoxybenzylamine. Note that the sterilizing / virus inactivating composition of the present invention may contain only one kind of amine compound, or may contain two or more kinds of amine compounds.

[0028] In the sterilizing / virus inactivating composition of the present invention, the concentration of the amine compound is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, still more preferably 0.5% by mass or more, even more preferably 0.8% by mass or more, and particularly preferably 1% by mass or more. Also, in the sterilizing / virus inactivating composition of the present invention, the concentration of the amine compound is preferably 10% by mass or less, and more preferably 5% by mass or less. When the concentration of the amine compound is 0.2% by mass or more, the bactericidal effect and the virus inactivation effect become more excellent. When the concentration of the amine compound is 10% by mass or less, it becomes difficult for the amine compound to remain on the object to be washed after using the bactericidal / virus inactivating composition of the present invention.

[0029] (Cationic surfactant) The bactericidal / virus inactivating composition of the present invention contains a cationic surfactant. By bringing the cationic surfactant into contact with bacteria or viruses, sterilization and virus inactivation can be performed. In particular, since the cationic surfactant exhibits a bactericidal effect even in a small amount, the bactericidal effect of the bactericidal / virus inactivating composition of the present invention is less likely to decrease even if it is diluted by water in the environment.

[0030] In the bactericidal / virus inactivating composition of the present invention, the cationic surfactant is not particularly limited, and examples thereof include amine compounds and quaternary ammonium compounds, and among them, quaternary ammonium compounds are preferable.

[0031] Further, in the bactericidal / virus inactivating composition of the present invention, the cationic surfactant is preferably at least one selected from the group consisting of didecyldimethylammonium chloride, didecyldimethylammonium methosulfate, didecylmethylpolyoxyethylammonium propionate, dioctyldimethylammonium chloride, alkylbenzyldimethylammonium chloride, cetylpyridinium chloride, benzethonium chloride, alkyldimethylhydroxyethylammonium chloride, tetraalkylammonium adipate, polyhexamethylenebiguanide hydrochloride, didecyldimethylammonium carbonate, and octyldecyldimethylammonium chloride. Among these cationic surfactants, quaternary ammonium compounds are more preferred. In particular, didecyldimethylammonium methosulfate, didecylmethylpolyoxyethylammonium propionate, alkylbenzyldimethylammonium chloride, dioctyldimethylammonium chloride, alkyldimethylhydroxyethylammonium chloride, and octyldecyldimethylammonium chloride are even more preferred. In the bactericidal / virus-inactivating composition of the present invention, these cationic surfactants may be contained alone or in plurality.

[0032] In the bactericidal / virus-inactivating composition of the present invention, the concentration of the cationic surfactant is preferably 0.006% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.03% by mass or more, and particularly preferably 0.05% by mass or more. When the concentration of the cationic surfactant is this high, the virus-inactivating effect by the cationic surfactant can be made more excellent. Also, the concentration of the cationic surfactant is preferably 2% by mass or less, more preferably 1.4% by mass or less, even more preferably 1.2% by mass or less, still more preferably 1% by mass or less, and particularly preferably 0.9% by mass or less. Even when the concentration of the cationic surfactant is this low, the virus-inactivating effect can be made more excellent.

[0033] (Other components) In the bactericidal / virus-inactivating composition of the present invention, in addition to the above components, surfactants, chelating agents, lower alcohols, other solvents, solubilizers, thickeners, enzymes, fragrances, coloring dyes, etc. may be contained.

[0034] The above surfactant is not particularly limited as long as it is a surfactant other than the cationic surfactant, and anionic surfactants, nonionic surfactants, amphoteric surfactants, etc. can be used. Examples of nonionic surfactants include polyoxyalkylene alkyl ethers, Pluronic type block polymers, reverse Pluronic type block polymers, Tetronic type block polymers, reverse Tetronic type block polymers, polyoxyalkylene alkyl phenyl ethers, fatty acid alkanolamides, polyoxyalkylene fatty acid alkanolamides, polyoxyalkylene fatty acid esters, polyoxyalkylene sorbitan fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, sucrose fatty acid esters, alkyl polyglycosides, polyoxyethylene methyl ether fatty acid esters, polyoxyalkylene alkyl amines, and the like. Examples of anionic surfactants include fatty acid salts, alkyl ether carboxylates, alkane sulfonates, α-olefin sulfonates, α-sulfomethyl ester salts, alkyl benzene sulfonates, alkyl succinates, alkyl sulfate esters, alkyl ether sulfate esters, and the like. Examples of amphoteric surfactants include alkyl betaines, alkyl amino betaines, alkyl amidopropyl betaines, alkyl hydroxy sulfobetaines, alkyl amine oxides, and the like.

[0035] As described above, in the bactericidal / virus inactivating composition of the present invention, the total concentration of the anionic surfactant, nonionic surfactant, and zwitterionic surfactant is preferably 2% by mass or less. The total concentration of the anionic surfactant, nonionic surfactant, and zwitterionic surfactant is more preferably 1.2% by mass or less, and even more preferably 1% by mass or less.

[0036] Chelating agents are not particularly limited, and examples thereof include trisodium nitrilotriacetate, tetrasodium ethylenediaminetetraacetate, disodium ethylenediaminetetraacetate, sodium methylglycinediacetate, sodium ethylenediaminetetramethylenephosphonate, sodium phosphonobutane tricarboxylate, sodium citrate, and the like. In addition, the sterilizing / virus inactivating composition of the present invention may contain only one of these chelating agents or may contain a plurality of types of chelating agents. When the sterilizing / virus inactivating composition of the present invention contains a chelating agent, the mass concentration of the chelating agent in the sterilizing / virus inactivating composition of the present invention is preferably 0.01 to 5% by mass, more preferably 0.05 to 2% by mass.

[0037] The sterilizing / virus inactivating composition of the present invention may contain a lower alcohol. However, from the viewpoint of further reducing the influence on an object to be washed made of plastic, as described above, in the sterilizing / virus inactivating composition of the present invention, the concentration of the lower alcohol is preferably 20% by mass or less. The concentration of the lower alcohol is more preferably 10% by mass or less, still more preferably 5% by mass or less, particularly preferably 1% by mass or less, and most preferably 0% by mass. Even when the sterilizing / virus inactivating composition of the present invention has a low concentration of the lower alcohol or does not contain the lower alcohol, it can exhibit an excellent sterilizing effect and an excellent virus inactivating effect.

[0038] In addition, in the sterilizing / virus inactivating composition of the present invention, the concentration of the alcohol containing the lower alcohol and the higher alcohol is preferably 20% by mass or less. The concentration of the alcohol is more preferably 10% by mass or less, still more preferably 5% by mass or less, particularly preferably 1% by mass or less, and most preferably 0% by mass. Since the concentration of the alcohol is thus low, it is possible to more sufficiently prevent an object to be washed made of plastic from being damaged and impairing the characteristics such as its appearance. In the present specification, alcohol refers to an alcohol having an unlimited number of carbon atoms. In addition, the valence of the alcohol is not particularly limited. When a plurality of types of alcohols are used, the concentration of the alcohol is the total concentration of the plurality of types of alcohols. In addition, when the alcohol concentration is 20% by mass or less, the sterilizing / virus inactivating composition of the present invention may not contain alcohol, and the alcohol concentration may be 0% by mass. It may not contain alcohol, and the alcohol concentration may be 0% by mass.

[0039] Furthermore, in the sterilizing / virus inactivating composition of the present invention, the concentration of the solvent (organic solvent) is preferably less than 20% by mass. The concentration of the above solvent is more preferably 10% by mass or less, still more preferably 5% by mass or less, particularly preferably 1% by mass or less, and most preferably 0% by mass. When the concentration of the solvent is this low, it is possible to more sufficiently prevent the object to be washed made of plastic from being damaged and its properties such as appearance from being impaired. In this specification, the solvent refers to an organic solvent. When a plurality of types of solvents are used, the concentration of the solvent is the total concentration of the plurality of types of solvents. In addition, when the concentration of the solvent is less than 20% by mass, the sterilizing / virus inactivating composition of the present invention may not contain the solvent, and the concentration of the solvent may be 0% by mass.

[0040] The sterilizing / virus inactivating composition of the present invention preferably further contains water. Water is blended as the remainder other than the other components, and its content is not particularly limited. Although water is not particularly limited, for example, tap water, distilled water, purified water, pure water, ion-exchanged water, etc. can be mentioned, and one or more of these can be used. In the sterilizing / virus inactivating composition of the present invention, the mass concentration of water is preferably 10.00 to 99.90% by mass, more preferably 40.00 to 99.80% by mass, still more preferably 70.00 to 99.60% by mass, and particularly preferably 90.00 to 99.50% by mass.

[0041] The sterilizing / virus inactivating composition of the present invention preferably has a pH of 9.0 to 13.0. The pH is more preferably 10.0 or higher. At such a pH, the virus inactivation effect is improved. In addition, since the pH of the sterilizing / virus inactivating composition is 13.0 or lower, it is possible to further prevent rough handling and easier deterioration of the object to be washed. As described above, the pH can be adjusted by controlling the amounts of acid agents such as sulfuric acid, hydrochloric acid, sulfamic acid, etc., and alkali agents such as sodium hydroxide, potassium hydroxide, sodium silicate, potassium silicate, etc.

[0042] Next, the use of the sterilizing / virus inactivating composition of the present invention will be described. As described above, the sterilizing / virus inactivating composition of the present invention is preferably a norovirus inactivating composition. Among them, the sterilizing / virus inactivating composition of the present invention is preferably a human norovirus inactivating composition. As shown in the examples described later, the sterilizing / virus inactivating composition of the present invention can exhibit an inactivating effect on both feline calicivirus and murine norovirus, and is applicable to the inactivation of human norovirus. Thus, in order to claim the effect on human norovirus, it is desirable that the inactivating effect on both feline calicivirus and murine norovirus has been demonstrated. In addition, the sterilizing / virus inactivating composition of the present invention also shows a high virus inactivating effect on influenza virus and coronavirus, which have lower drug resistance than norovirus.

[0043] The sterilizing / virus inactivating composition of the present invention can be used on the surfaces of hard materials and soft materials, but as described above, it is preferably used on the surface of hard materials. As shown in the examples described later, the sterilizing / virus inactivating composition of the present invention can exhibit a sterilizing effect and a virus inactivating effect with a contact time (action time) of only 30 seconds, and is applicable to the cleaning and disinfection of hard surfaces. Thus, when assuming cleaning and disinfection of hard surfaces, the contact time needs to be effective for 30 seconds. As the hard materials, as described above, for example, resins such as metal, ceramic, plastic, etc., glass, surface-treated wood, etc. can be mentioned. For example, plastic plates such as acrylic plates, resin toilets and toilet seats, etc. are particularly preferred. For example, the bactericidal and virus-inactivating composition of the present invention is preferably used in toilets. Especially in places where the toilet seat and the like are likely to crack due to detergents, a composition with little influence on resins such as the bactericidal and virus-inactivating composition of the present invention is suitable. In addition, in this specification, "used in toilets" means used for things existing in toilets, such as toilet bowls, toilet seats, floors, walls, etc.

[0044] Also, the bactericidal and virus-inactivating composition of the present invention may be used for sanitary materials. Since the bactericidal and virus-inactivating composition of the present invention exhibits excellent bactericidal effects and excellent virus-inactivating effects, by using sanitary materials containing such a bactericidal and virus-inactivating composition, bacterial infections and virus infections can be sufficiently prevented.

[0045] The sanitary materials are not particularly limited, but examples include masks, disposable gloves, disposable dishcloths, tissue papers, wet tissues, etc.

[0046] In addition, the bactericidal and virus-inactivating composition of the present invention may be added to hand wash liquids, neutral detergents, deodorants, etc. The bactericidal and virus-inactivating composition of the present invention, hand wash liquids, neutral detergents, deodorants, etc. containing the bactericidal and virus-inactivating composition of the present invention may be filled in pump bottles or spray bottles.

[0047] The bactericidal and virus-inactivating composition of the present invention exhibits excellent bactericidal effects and excellent virus-inactivating effects. In addition, when the lower alcohol concentration of the sterilizing / virus inactivating composition of the present invention is low (for example, 20% by mass or less), it is less likely to damage the object to be washed when the object to be washed is made of a resin such as plastic or is resin-coated. Of course, when the object to be washed is metal, ceramic, glass, surface-treated wood, etc., it is less likely to damage the object to be washed regardless of the lower alcohol concentration or the like. Further, even if it adheres to human skin, it is less likely to damage human skin. Furthermore, in the sterilizing / virus inactivating composition of the present invention, when the vapor pressure of the amine compound is 50 Pa or more, since the volatility is high, the components are less likely to remain after use. Therefore, when the sterilizing / virus inactivating composition of the present invention is used, even if a part of the sterilizing / virus inactivating composition of the present invention remains on the object to be washed and then a part of the sterilizing / virus inactivating composition of the present invention adheres to the skin of a person who touches the object to be washed, it is less likely to damage the skin of that person.

Examples

[0048] Examples for more specifically explaining the present invention are shown below, but the present invention is not limited to these examples. In the examples, unless otherwise specified, “%” means “% by mass”.

[0049] (Examples 1 to 25) and (Comparative Examples 1 to 14) Sterilizing / virus inactivating compositions according to Examples 1 to 25 and Comparative Examples 1 to 14 were prepared according to the formulations shown in Tables 1 to 3. In Tables 1 to 3, the manufacturers of the compounds, etc. are as follows. (Cationic surfactant) Benzyl dodecyl dimethyl ammonium chloride: Benzyl dimethyl alkyl ammonium chloride manufactured by Tokyo Chemical Industry Co., Ltd. Didecyl dimethyl ammonium methosulfate: Lipocard 210-80MSPG didecyl dimethyl ammonium methosulfate manufactured by Lion Specialty Chemicals Co., Ltd. Dioctyl dimethyl ammonium chloride: Bardac LF-80 dioctyl dimethyl ammonium chloride manufactured by Lonza Japan Co., Ltd. Alkyldimethylhydroxyethylammonium chloride: PRAEPAGEN HY manufactured by Clariant Japan K.K., alkyldimethylhydroxyethylammonium chloride with alkyl (C12-14) Didodecylmethylpolyoxyethylammonium propionate: Bardap26 manufactured by Lonza Japan K.K., didodecylmethylpoly(1-2)oxyethylammonium propionate

[0050] (Other surfactants) Alkylamine oxide: Cadenas DM12D-W manufactured by Lion Specialty Chemicals Co., Ltd., lauryldimethylamine oxide Polyoxyethylene alkyl ether: Fine Surf TD-90 manufactured by Aoki Yushi Kogyo Co., Ltd., polyoxyethylene(9)tridecyl ether Polyoxyalkylene alkyl ether: Neugen LP-100 manufactured by Daiichi Kogyo Seiyaku Co., Ltd., polyoxyalkylene lauryl ether Alkyl glucoside: Plantacare 1200UP manufactured by BASF Co., Ltd., lauryl glucoside Alkyl betaine: Obazoline LB manufactured by Toho Chemical Industry Co., Ltd., lauryl betaine Alkylamidopropyl betaine: Genagen CAB 818J manufactured by Clariant Japan K.K., coconut fatty acid amidopropyl betaine Alkyl alkanolamide: Aminon C11-S manufactured by Kao Corporation, coconut fatty acid N-methylethanolamide

[0051] (Chelating agent) Trisodium methylglycine diacetate: Trilon M manufactured by BASF Co., Ltd. Tetrasodium ethylenediaminetetraacetate: Trilon BX Powder manufactured by BASF Co., Ltd. Sodium citrate: Trisodium citrate dihydrate manufactured by Hayashi Junyaku Kogyo Co., Ltd.

[0052] (Other components) 72% dilute sulfuric acid: manufactured by Toagosei Co., Ltd. Ethyl alcohol: Ethanol (99.5) manufactured by FUJIFILM Wako Pure Chemical Corporation Isopropyl alcohol: 2-Propanol manufactured by FUJIFILM Wako Pure Chemical Corporation n-Propyl alcohol: 1-Propanol manufactured by FUJIFILM Wako Pure Chemical Corporation Potassium hydroxide: Manufactured by FUJIFILM Wako Pure Chemical Corporation Tripotassium phosphate: Manufactured by FUJIFILM Wako Pure Chemical Corporation Sodium hydrogen carbonate: Manufactured by FUJIFILM Wako Pure Chemical Corporation In Tables 1 to 3, the compounds listed as amine compounds are manufactured by Tokyo Chemical Industry Co., Ltd. The numerical values of the compositions in Tables 1 to 3 are the percentages by mass of the pure components of each component in the bactericidal / virus inactivating composition.

[0053]

Table 1

[0054]

Table 2

[0055]

Table 3

[0056] <Volatility test> Four Pro Wipe Soft Micro Wipers (manufactured by Oji Paper Co., Ltd.) were stacked and cross-folded 16 times, and 2 mL of the bactericidal / virus inactivating composition of each example and each comparative example was dropped. Using this, a 50×20 mm glass was wiped back and forth twice, and the time until it dried was measured. The evaluation criteria are as follows. The results are shown in Tables 1 to 3. ○: Dries within 30 seconds △: Dries in 30 to 45 seconds ×: Dries in 45 seconds or more If the evaluation is △ or higher, the volatility is good.

[0057] <Test on the effect on resin> Evaluation was carried out by the 1 / 4 ellipse method (described on page 482, No. 10, Volume 26 (2014) of Molding Process, published by the Plastic Molding Processing Society). A test piece (127 mm × 10 mm × thickness 1.6 mm, manufactured by Nippon Test Panel Co., Ltd.) made of ABS resin or acrylic resin was fixed along the circumference of an elliptical jig (major axis 127 mm, minor axis 38.1 mm). Two four-folded Prowipe Soft Micro Wipers (manufactured by Oji Paper Co., Ltd.) were stacked on it, 5 mL of the sterilization / virus inactivation composition of each example and each comparative example was dropped, and it was left standing for 84 hours in an environment of room temperature 20 °C and humidity 50%. The presence or absence of crack generation in the test piece was visually observed, the distance from the end of the test piece on the minor axis side of the 1 / 4 elliptical jig to the crack generation position was measured, and the critical strain was calculated. ○: No crack generation △: Cracks occurred and the critical strain was 0.6% or more ×: Cracks occurred and the critical strain was less than 0.6% In addition, if the evaluation is △ or more, the influence on the resin is sufficiently small and it is good. Also, even if the evaluation is ×, if the results of the sterilization test and virus inactivation test described later are good, it is good as a sterilization / virus inactivation composition.

[0058] <Sterilization test> (1) Escherichia coli (Escherichia coli NBRC3972), Staphylococcus aureus (Staphylococcus aureus NBRC12732), and Pseudomonas aeruginosa (Pseudomonas aeruginosa NBRC13275) were each inoculated into a normal broth medium and cultured at 35 °C for 24 hours to obtain a bacterial solution.

[0059] (2) The sterilization / virus inactivation composition of each example and each comparative example and the bacterial solution were mixed at a ratio (by volume) of 99:1. After 30 seconds at room temperature, one platinum loop was transplanted into SCDLP medium and cultured at 35 °C for 48 hours, and then the life and death of the bacteria were determined.

[0060] (3) When turbidity was observed in the SCDLP medium, it was judged that the bacteria did not die, and when no turbidity was observed, it was judged that the bacteria died.

[0061] Also, using the sterilizing / virus inactivating compositions of each example and each comparative example diluted 10-fold, the same operations as in (1) to (3) above were repeated to determine the viability of the bacteria.

[0062] The evaluation criteria are as follows. The results are shown in Tables 1 to 3. [Regarding Escherichia coli] ○: Escherichia coli was killed. ×: Escherichia coli was not killed. [Regarding Staphylococcus aureus] ○: Staphylococcus aureus was killed. ×: Staphylococcus aureus was not killed. [Regarding Pseudomonas aeruginosa] ○: Pseudomonas aeruginosa was killed. ×: Pseudomonas aeruginosa was not killed.

[0063] (Virus Inactivation Test) (Effect of Inactivating Feline Calicivirus) (1) Feline calicivirus was infected into CRFK cells (ATCC CCL-94), which are feline kidney-derived established cells, and the cells were cultured. (2) Next, whether the cells were infected with feline calicivirus was confirmed by the cytopathic effect (CPE). After confirming the cytopathic effect, the cultured cells were disrupted by repeating the freeze-thaw cycle of the cultured cells. (3) The disrupted solution of the cultured cells was centrifuged, and the supernatant was collected to obtain a virus solution. (4) The sterilizing / virus inactivating compositions according to each example and each comparative example were mixed with the virus solution at a ratio of 9:1 (by volume), and after 30 seconds at room temperature, the mixture was diluted 100-fold with OPTI-MEM medium to stop the action of each sterilizing / virus inactivating composition on the virus. The solution obtained by this step was designated as the virus solution after the action of the sterilizing / virus inactivating composition for 30 seconds. (5) Immediately after mixing OPTI-MEM medium and the virus solution at a ratio of 9:1 (by volume), the resulting solution was diluted 100-fold with OPTI-MEM medium to obtain a virus solution of the sterilization / virus inactivation composition with 0-second action. (6) The virus solution of the sterilization / virus inactivation composition with 0-second action and the virus solution of the sterilization / virus inactivation composition with 30-second action were each serially diluted 10-fold with OPTI-MEM medium. The medium in the 96-well microplate in which CRFK cells were cultured was discarded, and 100 μL of each serial dilution was added. (7) The CRFK cells to which the serial dilutions of the virus solution of the sterilization / virus inactivation composition with 0-second action and the virus solution of the sterilization / virus inactivation composition with 30-second action were added were cultured at 37 °C under 5% CO2 for 4 days. (8) Using the CPE of the cultured CRFK cells as an index, the viral infectivity titer (logarithm) of each virus solution was quantified by TCID50 (Tissue Culture Infectious Dose 50%). (9) The steps (1) to (8) above were independently performed 3 times. The average value of the viral infectivity titer calculated using the virus solution of the sterilization / virus inactivation composition with 0-second action was taken as the viral infectivity titer at 0 seconds of action time, and the average value of the viral infectivity titer calculated using the virus solution of the sterilization / virus inactivation composition with 30-second action was taken as the value of the viral infectivity titer at 30 seconds of action time. The evaluation criteria are as follows. The results are shown in Tables 1 to 3. ○: Decrease in infectivity titer of 3.0 or more △: Decrease in infectivity titer of 2.0 or more and less than 3.0 ×: Decrease in infectivity titer of less than 2.0 If the decrease in infectivity titer is 2.0 or more (evaluation of △ or more), the inactivation effect of feline calicivirus is good.

[0064] (Inactivation effect on murine norovirus) (1) Murine norovirus was infected into RAW 264.7 cells (ATCC TIB-71), a macrophage-derived cell line of mice, and the cells were cultured. (2) Next, it was confirmed whether the mouse norovirus had infected by the cytopathic effect (CPE). After confirming the cytopathic effect, the cultured cells were disrupted by repeating the freeze-thaw cycle of the cultured cells. (3) The disrupted solution of the cultured cells was centrifuged, and the supernatant was collected to obtain a virus solution. (4) The bactericidal / virus inactivating composition according to each example and each comparative example was mixed with the virus solution at a ratio (volume) of 9:1, and after 30 seconds at room temperature, it was diluted 100-fold with DMEM medium containing 10% fetal bovine serum to stop the action of each bactericidal / virus inactivating composition on the virus. The solution obtained by this step was used as a virus solution with the bactericidal / virus inactivating composition acting for 30 seconds. (5) Immediately after mixing the DMEM medium containing 10% fetal bovine serum and the virus solution at a ratio (volume) of 9:1, the obtained solution was diluted 100-fold with DMEM medium containing 10% fetal bovine serum to obtain a virus solution with the bactericidal / virus inactivating composition acting for 0 seconds. (6) The virus solution with the bactericidal / virus inactivating composition acting for 0 seconds and the virus solution with the bactericidal / virus inactivating composition acting for 30 seconds were each serially diluted 10-fold with DMEM medium containing 10% fetal bovine serum. 50 μL of each serial dilution was added to a 96-well microplate into which 50 μL of RAW 264.7 cells had been dispensed per well. (7) The RAW 264.7 cells to which the serial dilutions of the virus solution with the bactericidal / virus inactivating composition acting for 0 seconds and the virus solution with the bactericidal / virus inactivating composition acting for 30 seconds had been added were cultured at 37 °C and 5% CO2 for 4 days. (8) Using the CPE of the cultured RAW 264.7 cells as an index, the virus infectivity titer (logarithm) of each virus solution was quantified by TCID 50 (Tissue Culture Infectious Dose 50%). (9) The steps (1) to (8) above were performed independently three times, and the average value of the viral infectivity titer calculated using the virus solution with 0-second action of the sterilization / virus inactivation composition was taken as the viral infectivity titer at the action time of 0 seconds, and the average value of the viral infectivity titer calculated using the virus solution with 30-second action of the sterilization / virus inactivation composition was taken as the value of the viral infectivity titer at the action time of 30 seconds. The evaluation criteria are as follows. The results are shown in Tables 1 to 3. ○: Decrease in infectivity titer of 3.0 or more △: Decrease in infectivity titer of 2.0 or more and less than 3.0 ×: Decrease in infectivity titer of less than 2.0 In addition, if the decrease in infectivity titer is 2.0 or more (evaluation is △ or more), the inactivation effect of murine norovirus is good.

[0065] (Influenza virus inactivation effect) (1) Influenza virus was infected into MDCK cells, which are immortalized cells derived from canine renal tubular epithelial cells, and the cells were cultured. (2) Next, whether the cells were infected with influenza virus was confirmed by the cytopathic effect (CPE). After confirming the cytopathic effect, the cultured cells were disrupted by repeating the freeze-thaw of the cultured cells. (3) The disrupted solution of the cultured cells was centrifuged, and the supernatant was collected to obtain a virus solution. (4) The sterilization / virus inactivation composition according to each example and each comparative example and the virus solution were mixed at a ratio (by volume) of 9:1, and after 30 seconds at room temperature, they were diluted 100-fold with EMEM medium containing 2 μg / mL trypsin (crystalline from bovine spleen) (hereinafter referred to as trypsin-containing EMEM medium) to stop the action of each sterilization / virus inactivation composition on the virus. The solution obtained by this step was used as the virus solution with 30-second action of the sterilization / virus inactivation composition. (5) Immediately after mixing trypsin-containing EMEM medium and the virus solution at a ratio of 9:1 (by volume), the resulting solution was diluted 100-fold with trypsin-containing EMEM medium to obtain a virus solution of the sterilized and virus-inactivated composition with 0-second action. (6) The virus solution of the sterilized and virus-inactivated composition with 0-second action and the virus solution of the sterilized and virus-inactivated composition with 30-second action were each serially diluted 10-fold with trypsin-containing EMEM medium. The medium in the 96-well microplate in which MDCK cells were cultured was discarded, and 100 μL of each serial dilution was added. (7) The MDCK cells to which the serial dilutions of the virus solution of the sterilized and virus-inactivated composition with 0-second action and the virus solution of the sterilized and virus-inactivated composition with 30-second action were added were cultured at 37 °C under 5% CO2 for 4 days. (8) Using the CPE of the cultured MDCK cells as an index, the viral infectivity titer (logarithm) of each virus solution was quantified by TCID 50 (Tissue Culture Infectious Dose 50%). (9) The steps (1) to (8) above were independently performed 3 times. The average value of the viral infectivity titer calculated using the virus solution of the sterilized and virus-inactivated composition with 0-second action was taken as the viral infectivity titer at 0 seconds of action time, and the average value of the viral infectivity titer calculated using the virus solution of the sterilized and virus-inactivated composition with 30-second action was taken as the value of the viral infectivity titer at 30 seconds of action time. The evaluation criteria are as follows. The results are shown in Tables 1 to 3. ○: Decrease in infectivity titer of 3.0 or more △: Decrease in infectivity titer of 2.0 or more and less than 3.0 ×: Decrease in infectivity titer of less than 2.0 If the decrease in infectivity titer is 2.0 or more (evaluation is △ or more), the influenza virus inactivation effect is good.

[0066] (Human coronavirus inactivation effect) (1) Human coronavirus was infected into MRC-5 cells, which are human normal diploid fibroblasts, and the cells were cultured. (2) Next, it was confirmed whether the cells were infected with human coronavirus by the cytopathic effect (CPE). After confirming the cytopathic effect, the cultured cells were disrupted by repeating the freeze-thaw cycle of the cultured cells. (3) The culture cell lysate was centrifuged, and the supernatant was collected to obtain a virus solution. (4) The sterilizing / virus inactivating composition according to each example and each comparative example was mixed with the virus solution at a ratio (by volume) of 9:1. After 30 seconds at room temperature, it was diluted 100-fold with MEM medium containing 5% FBS (fetal bovine serum) (hereinafter referred to as FBS-containing MEM medium) to stop the action of each sterilizing / virus inactivating composition on the virus. The solution obtained by this step was used as the virus solution after the sterilizing / virus inactivating composition had acted for 30 seconds. (5) Immediately after mixing the FBS-containing MEM medium and the virus solution at a ratio (by volume) of 9:1, the resulting solution was diluted 100-fold with the FBS-containing MEM medium to obtain a virus solution after the sterilizing / virus inactivating composition had acted for 0 seconds. (6) The virus solution after the sterilizing / virus inactivating composition had acted for 0 seconds and the virus solution after the sterilizing / virus inactivating composition had acted for 30 seconds were each serially diluted 10-fold with the FBS-containing MEM medium. The medium in the 96-well microplate in which MRC-5 cells were cultured was discarded, and 100 μL of each serial dilution was added. (7) The MRC-5 cells to which the serial dilutions of the virus solution after the sterilizing / virus inactivating composition had acted for 0 seconds and the virus solution after the sterilizing / virus inactivating composition had acted for 30 seconds were added were cultured under the conditions of 35 °C and 5% CO2 for 5 days. (8) Using the CPE of the cultured MRC-5 cells as an index, the virus infectivity titer (logarithm) of each virus solution was quantified by TCID 50 (Tissue Culture Infectious Dose 50%). (9) The steps (1) to (8) above were independently performed three times. The average value of the viral infectivity titer calculated using the virus solution with the sterilizing / virus inactivating composition acting for 0 seconds was taken as the viral infectivity titer at the action time of 0 seconds, and the average value of the viral infectivity titer calculated using the virus solution with the sterilizing / virus inactivating composition acting for 30 seconds was taken as the value of the viral infectivity titer at the action time of 30 seconds. The evaluation criteria are as follows. The results are shown in Tables 1 to 3. ○: A decrease in infectivity titer of 3.0 or more △: A decrease in infectivity titer of 2.0 or more and less than 3.0 ×: A decrease in infectivity titer of less than 2.0 In addition, if the decrease in infectivity titer is 2.0 or more (the evaluation is △ or more), the inactivation effect on human coronavirus is good.

[0067] From Tables 1 to 3, it was found that the sterilizing / virus inactivating composition according to the examples exhibits excellent sterilizing effects and excellent virus inactivating effects. In addition, it was found that even when the sterilizing / virus inactivating composition is diluted with water, it exhibits sufficient sterilizing effects. In addition, the sterilizing / virus inactivating composition according to the examples exhibits the above-described excellent sterilizing effect and excellent virus inactivating effect without blending a lower alcohol (alcohol). Since the sterilizing / virus inactivating compositions according to Examples 1 to 19, 24, and 25 do not contain a lower alcohol (alcohol) or contain a very low concentration of a lower alcohol, even when used for an object to be washed made of a material such as an ABS resin or an acrylic resin, the object to be washed can be prevented from being damaged and its appearance can be prevented from being impaired, and the effect is remarkable. Further, since the sterilizing / virus inactivating compositions according to Examples 20 and 21 contain a lower alcohol but at a low concentration, even when used for an object to be washed made of a material such as an ABS resin or an acrylic resin, it is possible to sufficiently prevent the appearance from being impaired. The sterilizing / virus inactivating compositions according to Examples 22 and 23 contain a certain amount of a lower alcohol, and when used for an object to be washed made of a material such as an ABS resin or an acrylic resin, there is a risk of damaging the object to be washed. However, similar to the sterilizing / virus inactivating compositions according to other examples, they can exhibit an excellent sterilizing effect and an excellent virus inactivating effect, and can sufficiently prevent infectious diseases caused by bacteria and viruses. Note that a sanitary material containing such a sterilizing / virus inactivating composition according to the examples can exhibit an excellent sterilizing effect and an excellent virus inactivating effect, and can sufficiently prevent infectious diseases caused by bacteria and viruses.

Claims

1. An amine compound having an acid dissociation constant (pKa) of 9.0 or more, and a cationic surfactant, and the amine compound is at least one selected from the group consisting of monoisopropanolamine, aminobutanol, methylethanolamine, ethyethanolamine, butylethanolamine, methylpropanolamine, ethylpropanolamine, dimethylaminoethanol, diethylaminoethanol, ethylmethylaminoethanol, dimethylaminopropanol, diethylaminopropanol, aminomethylpropanol, aminoethylpropanol, aminopropylpropanol, aminobutylpropanol, ethylenediamine, triethylenetetramine, piperidine, pyrrolidine, aminomethylbenzylamine, aminoethylbenzylamine, and aminoethoxybenzylamine. A sterilizing / virus inactivating composition characterized by the above.

2. The sterilizing / virus inactivating composition according to claim 1, wherein the amine compound has a vapor pressure of 50 Pa or more.

3. The sterilizing / virus inactivating composition according to claim 1 or 2, wherein the cationic surfactant is a quaternary ammonium compound.

4. The sterilizing / virus inactivating composition according to any one of claims 1 to 3, wherein the cationic surfactant contains at least one selected from the group consisting of tetraalkylammonium salts, didecylmethylpolyoxyethylammonium salts, alkylbenzyldimethylammonium salts, cetylpyridinium salts, benzethonium salts, alkyldimethylhydroxyethylammonium salts, and polyhexamethylenebiguanide hydrochloride.

5. The sterilizing / virus inactivating composition according to any one of claims 1 to 4, wherein the total concentration of anionic surfactant, nonionic surfactant, and zwitterionic surfactant in the sterilizing / virus inactivating composition is 2% by mass or less.

6. The sterilizing / virus inactivating composition according to any one of claims 1 to 5, wherein the pH is 9.0 to 13.

0.

7. The sterilizing / virus inactivating composition according to any one of claims 1 to 6, wherein the concentration of the lower alcohol in the sterilizing / virus inactivating composition is 20% by mass or less.

8. The sterilizing / virus inactivating composition according to any one of claims 1 to 7, which is a norovirus inactivating composition.

9. The sterilizing / virus inactivating composition according to any one of claims 1 to 8, which is used on the surface of a hard material.

10. A sanitary material comprising the sterilizing / virus inactivating composition according to any one of claims 1 to 9.

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