Blood separation device

Abstract

To provide a blood separation tool that can prevent a broken piece of a component from mixing in a blood sample by a simple structure.SOLUTION: A blood separation tool 1 includes a container body 10, a blood separation cylinder 30, and a lid member 50. When the lid member 50 is pushed in, the lid member 50 pushes the blood separation cylinder 30 to a first position while the relative positional relation between a core bar 57 and the blood separation cylinder 30 in the axial direction is maintained. When the lid member 50 is pushed deeper, a stopper piece 35 is plastically deformed and the core bar 57 becomes capable of moving to the back of the blood separation cylinder 30. When the lid member 50 is pushed to a fixation position, a sealing plug 59 is engaged with a through-hole 31h in the blood separation cylinder 30 and the through-hole 31h is closed.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a blood separation device, and more particularly to a blood separation device which has a simple structure and is capable of preventing broken pieces of components from being mixed into a blood sample. [Background technology]

[0002] Conventionally, a biological sample separation instrument capable of separating blood collected from a subject without using a centrifuge has been known (see, for example, Patent Document 1). The biological sample separation instrument of Patent Document 1 has a blood collection container and a cylinder inserted into the blood collection container, and the cylinder is provided with a separation membrane for separating the blood. By placing blood collected from the subject in the blood collection container and inserting the cylinder into the blood collection container, the blood passes through the separation membrane and is separated into blood cell components and serum or plasma. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2003-270239 A Summary of the Invention [Problem to be solved by the invention]

[0004] The biological sample separation instrument of Patent Document 1 is configured so that a thin-walled portion of the cylindrical body breaks while the cylindrical body is being inserted into the blood collection container so that the cylindrical body can be moved to the back of the blood collection container. However, the thin-walled portion is a disk-shaped area that expands in the radial direction of the cylindrical body, and in Patent Document 1, this thin-walled portion is broken by twisting it off, so the manner in which the thin-walled portion breaks varies depending on the strength with which the user turns the knob, and in some cases, broken pieces may get mixed into the cylindrical body.

[0005] Therefore, the present invention has been made in view of these points, and relates to a blood separation device capable of separating blood without using a centrifuge, and aims to provide a blood separation device having a simple structure and capable of preventing fragments of parts from being mixed into a blood sample.

Means for Solving the Problems

[0006] The blood separation device of the present invention includes a container body having a housing portion for housing blood collected from a subject, a blood separation cylinder that is formed in a cylindrical shape, has a filtering material for separating blood provided therein, and is inserted into the housing portion from above, a lid member that is attached to the upper end portion of the container body by screwing in a state where the blood separation cylinder is inserted into the housing portion, a blood separation device in which blood is separated by the filtering material while the lid member is screwed in and the blood separation cylinder is inserted into the housing portion by being pushed by the lid member, the lid member has a core rod with a sealing plug attached to the tip, the blood separation cylinder has a stopper piece that abuts against the lid member when the lid member is screwed in, when the lid member is screwed in, the blood separation cylinder is pushed by the lid member and inserted to a first position while maintaining the relative positional relationship in the axial direction between the core rod and the blood separation cylinder, when the lid member is further screwed in, the stopper piece is plastically deformed, so that the core rod can move to the back side of the blood separation cylinder, and when the lid member is screwed to a fixed position, the sealing plug fits into a through hole in the blood separation cylinder and the through hole is closed.

[0007] In one embodiment of the present invention, the blood separation cylinder has a cylindrical shape, and the stopper piece is formed to protrude from the upper end portion of the blood separation cylinder toward the lid member side.

[0008] In one embodiment of the present invention, a pair of said stopper pieces are provided, and the first stopper piece and the second stopper piece are formed at intervals of 180° in the circumferential direction of the blood separation cylinder.

[0009] In one embodiment of the present invention, the stopper piece has a protruding portion which is a portion that contacts the lid member, and a support portion that connects the protruding portion and the cylindrical portion of the blood separation cylinder and is formed so as to be preferentially deformed when the stopper piece is plastically deformed.

[0010] In one embodiment of the present invention, the protruding portion of the stopper piece is configured to fall inward in the radial direction of the blood separation cylinder while the lid member is being screwed toward the fixed position.

[0011] In one embodiment of the present invention, the support portion is configured to break while the lid member is being screwed toward the fixed position, whereby the protruding amount of the protruding portion is reduced and the mandrel can move toward the back side of the blood separation cylinder.

[0012] In one embodiment of the present invention, the top of the protruding portion is formed in a semi-circular shape.

[0013] In one embodiment of the present invention, the screw connection between the screw portion of the container body and the screw portion of the lid member is configured such that the lid member needs to be rotated by 1440° or more from when the screw portions mesh with each other until the lid member is screwed to the fixed position.

[0014] In one embodiment of the present invention, the sealing plug is configured to be detached from the mandrel when the lid member is rotated to pull out the mandrel after the sealing plug is once fitted into the through hole.

[0015] (Explanation of terms) When separating blood, depending on the purpose of the test, blood may be separated into blood cell components and plasma, or into blood cell components and serum. In this specification, these are not distinguished in detail and may be expressed, for example, as "separating into blood cell components and plasma or the like".

Advantages of the Invention

[0016] According to the present invention, there is provided a blood separation device capable of separating blood without using a centrifuge, having a simple structure, and capable of preventing fragments of parts from mixing into a blood sample.

Brief Description of the Drawings

[0017]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Modes for Carrying Out the Invention

[0018] Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. FIG. 1 is a diagram showing the components of the blood separation device separated. FIG. 2 is a diagram showing the container body, where FIG. 2(a) is a front view and FIG. 2(b) is a bottom view. FIG. 3 is a diagram showing the blood separation cylinder, where FIG. 3(a) is a plan view and FIG. 3(b) is a front view. FIG. 4 is a cross-sectional view of the liquid separation cylinder. In the following description, terms indicating directions such as "up and down" and "left and right" are used corresponding to the directions of the components depicted in the drawings.

[0019] As shown in FIG. 1, the blood separation device 1 of the present embodiment includes a container body 10, a blood separation cylinder 30, and a lid member 50. The blood separation device 1 has a function of separating the blood collected from the subject and a function of storing and holding the separated blood. In FIG. 1, the symbol Ax indicates the axis of the container body 10, the blood separation cylinder 30, and the lid member 50. As understood from FIG. 1, in the present embodiment, in the assembled state, the container body 10, the blood separation cylinder 30, and the lid member 50 are configured to be coaxial.

[0020] As shown in FIGS. 1 and 2, the container body 10 is formed in a cylindrical shape as a whole and has an accommodation portion 15 provided inside. The container body 10 is formed of a resin material as an example. In the present embodiment, the resin material is transparent. The accommodation portion 15 is a substantially cylindrical space. A partition wall 17 is formed inside the accommodation portion 15, and this partition wall 17 constitutes the bottom surface of the accommodation portion 15. In the present embodiment, the partition wall 17 is not in a flat plate shape but is formed in a gently curved concave shape.

[0021] The inner diameter of the accommodation portion 15 may be constant, but in the present embodiment, the inner wall of the accommodation portion 15 is formed in a slightly tapered shape so that the inner diameter of the accommodation portion 15 gradually decreases as it approaches the partition wall 17. The blood collected from the subject is accommodated in the accommodation portion 15. A predetermined amount of buffer solution may be accommodated in the accommodation portion 15 in advance.

[0022] The upper end of the accommodating portion 15 is open, and a threaded portion 13 having a spiral thread is formed on the outer periphery of the upper end of the container body 10. This threaded portion 13 is formed so as to be screwed with a threaded portion (detailed illustration is omitted) of a lid member 50 described later, whereby the lid member 50 can be screwed and attached to the container body 10.

[0023] Inside the container body 10, a rib 19 is formed below the partition wall 17, whereby the partition wall 17 is reinforced. The rib 19 is not limited to a specific shape, and for example, it may be formed in a shape like a ten o'clock shape.

[0024] The blood separation cylinder 30 is a member inserted into the container body 10, and as shown in FIGS. 3 and 4, it is formed in an overall elongated cylindrical shape. Inside the internal space 31 of the blood separation cylinder 30, a liquid component accommodating portion 32, a filter medium accommodating portion 33, and a through hole 31h are provided.

[0025] The liquid component accommodating portion 32 is a cylindrical space provided inside the cylinder of the blood separation cylinder 30, and as shown in FIG. 4, it has a first space 32a and a second space 32b formed below it with a relatively small inner diameter.

[0026] The through hole 31h is formed at an annular protrusion 34 formed inside the cylinder of the blood separation cylinder 30. The annular protrusion 34 is a portion formed so as to project radially inward from the inner peripheral surface inside the cylinder of the blood separation cylinder 30. The through hole 31h is a hole with a circular contour as shown in FIG. 3(b). The position of the center of the through hole 31h coincides with the axis Ax of the cylinder of the blood separation cylinder 30. The annular protrusion 34 is a structural portion to which a sealing plug 59 provided at the tip of the mandrel 57 of the lid member 50 is pressed as described later. In order to enhance the sealing performance by the sealing plug 59, an inverted frustoconical tapered surface 34s may be formed on the annular protrusion 34.

[0027] The filter medium housing portion 33 is formed at the lower end inside the cylinder of the blood separation cylinder 30. The filter medium housing portion 33 is a cylindrical space and communicates with the liquid component housing portion 32 through the through hole 31h. The filter medium 21 disposed in the filter medium housing portion 33 is made of a material that allows the passage of plasma or serum in the blood but does not allow the passage of blood cell components. The filter medium 21 may be, for example, a separation membrane.

[0028] As shown in FIG. 4, a rubber gasket 42 is attached to the outer periphery of the lower end of the blood separation cylinder 30. The gasket 42 is a member for preventing blood from leaking through the space between the outer peripheral surface of the blood separation cylinder 30 and the inner peripheral surface of the container body 10 when the blood separation cylinder 30 is inserted into the container body 10. The cross-sectional shape of the gasket 42 itself is not particularly limited, and for example, an annular protrusion in the shape of a rib may be appropriately provided on the outer peripheral surface.

[0029] Subsequently, the structural portions provided on the outer periphery and the upper end of the blood separation cylinder 30 will be described.

[0030] One or more flange portions 38 (see FIG. 3) are formed on the outer periphery of the blood separation cylinder 30. In this example, a first flange portion 38a and a second flange 38b are formed. The first flange portion 38a located below abuts against the upper end portion of the peripheral wall of the container body 10 when the blood separation cylinder 30 is inserted into the container body 10, and has a function of restricting the relative movement in the axial direction between the blood separation cylinder 30 and the container body 10.

[0031] At the upper end of the blood separation cylinder 30, a pair of stopper pieces 35-1 and 35-2 (also simply referred to as stopper piece 35) are formed. Each of the stopper pieces 35-1 and 35-2 protrudes in the direction toward the lid member 50 side during the assembly of the blood separation device 1. As shown in Fig. 3(b), in this example, the pair of stopper pieces 35-1 and 35-2 are formed at intervals of 180° along the circumferential direction of the blood separation cylinder. In other words, the two stopper pieces 35-1 and 35-2 are formed at equal intervals in the circumferential direction. The stopper piece 35 prevents the sealing plug 59, which will be described later, from being inserted into the through-hole 35h until the final stage of blood separation, and plays a role of keeping the separated plasma or the like in a state where it can flow into the liquid component storage part 32 during blood separation. The pair of stopper pieces 35-1 and 35-2 have the same shape in this example.

[0032] More specifically, as shown in Fig. 3(b), the stopper piece 35 has a protruding part 35a that protrudes upward from the upper end of the blood separation cylinder 30, and a support part 35b that connects the protruding part 35a and the cylindrical part of the blood separation cylinder 30. The protruding part 35a is formed in a plate shape, and its upper end is a semi-circular R part.

[0033] The upper end part of the protruding part 35a is a part that moves while rubbing against the inner surface of the lid member 50 as will be described later. Therefore, it is preferable that such an R part is formed so as to slide smoothly. In the case of such a shape, the top of the protruding part 35a comes into point contact with the inner surface of the lid member 50, so smooth sliding is realized. As shown in the cross-sectional view of Fig. 4, an R part 35r may be formed at the top of the stopper piece 35.

[0034] The function of the support portion 35b is such that when a force equal to or greater than a predetermined value is applied vertically downward (downward in the axial direction of the blood separation cylinder 30) to the protruding portion 35a, this portion preferentially undergoes plastic deformation, causing the stopper pieces 35-1 and 35-2 to deform radially inward. As long as it has such a function, the support portion 35b can have any shape. In the example of Fig. 3(a), an opening 37 is formed below the protruding portion 35a, the protruding portion 35a is located above it, and the protruding portion 35a is connected to the cylindrical portion of the blood separation cylinder 30 by two support portions 35b on both the left and right sides. The height by which the protruding portion 35a protrudes from the upper surface of the cylindrical portion of the blood separation cylinder 30 depends on the size of the entire product, etc., but is preferably within the range of, for example, 1 mm to 10 mm (1 mm or more and 10 mm or less), and particularly preferably within the range of 2 mm to 5 mm.

[0035] As shown in Fig. 1, the lid member 50 has a lid body 55, a mandrel 57, and a sealing plug 59.

[0036] The lid body 55 is a member that closes the upper end opening of the blood separation cylinder 30, and has an upper surface portion 51, a cylindrical peripheral wall portion 52 formed downward from the upper surface, and a support portion 53 that supports the mandrel 57. A screw portion (detailed illustration is omitted) is formed on the inner peripheral surface of the peripheral wall portion 52, and this screw portion is screwed into the screw portion 13 of the blood separation cylinder 30.

[0037] The inner surface 51a of the upper surface portion 51 is formed as a flat surface. Although not shown, the inner surface 51a is formed in an annular shape when the lid body 55 is viewed from the lower surface side. As will be described later, the inner surface 51a is the surface on which the tip of the protruding portion 35a (see Fig. 3) slides when the lid member 50 is attached to the blood separation cylinder 30.

[0038] The mandrel 57 extends straight along the direction of the axis Ax of the lid member 50. Although not limited, the mandrel 57 may be formed separately from the lid body 55 and held by the support portion 53. Alternatively, the mandrel 57 may be provided as a part of the lid member 50.

[0039] A sealing plug 59 is attached to the tip of the mandrel 57. The sealing plug 59 is formed of, for example, an elastic resin material. The sealing plug 59 is a member that is inserted into the through-hole 31h to block the hole.

[0040] The mandrel 57 and the sealing plug 59 may be connected, for example, by inserting the tip of the mandrel 57 into a cylindrical hole formed in the sealing plug 59. On the other hand, after the sealing plug 59 is inserted into the through-hole 31h, if the mandrel 57 is pulled out, the sealing plug 59 may be formed so as not to come off from the through-hole 31h and the tip of the mandrel 57 can come out of the hole of the sealing plug 59. Thereby, it becomes possible to use the subject's blood for inspection while keeping it separated.

[0041] (Procedure for using the blood separation device) The procedure for using the blood separation device 1 configured as described above will be described below with reference to FIGS. 5 to 8. FIG. 5 is a flowchart showing the procedure for using the blood separation device 1. Hereinafter, the procedure for the user to collect their own blood and store it in the blood separation device 1 will be described. In the state before use, it is assumed that a lancet and a microvolume blood sampler (not shown) are prepared. Note that the device for collection does not need to be limited to a specific one, but for example, a microvolume blood sampler such as Japanese Patent No. 5909470 may be used.

[0042] First, in step S1, the user pricks the fingertip with a micro needle using a lancet to let the blood flow out and collects it with the above-described microvolume blood sampler. The user transfers the collected blood to the container body 10 and mixes it with the buffer solution by pressing the spout portion at the tip of the microvolume blood sampler.

[0043] Next, in Step 2, the user inserts a mandrel 57 having a sealing plug 59 at its tip into the blood separation cylinder 30, and inserts the blood separation cylinder 30 together with the lid member 50 into the container body 10. Until the blood separation cylinder 30 is inserted to a certain position within the container body 10, the threaded portion (not shown) of the lid member 50 and the threaded portion 13 of the container body 10 do not engage with each other. Therefore, the user presses the lid member 50 by hand and pushes the blood separation cylinder 30 into the container body 10.

[0044] FIG. 6(a) shows a state where the top of the stopper piece 35 is in contact with the inner surface 51a of the lid member 50, but the sealing plug 59 has not yet closed the through hole 31h. The blood separation cylinder 30 and the lid member 50 are pushed down until the threaded portion (not shown) of the lid member 50 engages with the threaded portion 13 of the container body 10.

[0045] Next, in Step 3, the lid member 50 is screwed in to insert the blood separation cylinder 30 into the container body 10. Specifically, when the lid member 50 is screwed into the threaded portion 13 of the container body 10, the blood separation cylinder 30 is pushed by the lid member 50 and slowly pushed downward. At this time, the blood separation cylinder 30 moves only downward without rotating around the axis Ax. On the other hand, since the lid member 50 rotates around the axis Ax, the top of the stopper piece 35 and the inner surface 51a of the lid member 50 rotate relative to each other while rubbing against each other.

[0046] When the blood separation cylinder 30 is slowly pushed downward, the mixture of blood and buffer solution contained in the container body 10 passes through the filter medium 21. Among the mixture, the liquid components, plasma or serum, pass through the filter medium 21 and gradually flow into the blood separation cylinder 30 through the through hole 31h. The blood cell components are blocked from moving by the filter medium 21 and remain between the tip of the blood separation cylinder 30 and the accommodating portion 15 of the container body 10. For example, unlike a configuration where the user pushes the blood separation cylinder 30 into the container body 10 by hand, a substantially uniform pressure is applied to the mixed liquid during blood separation, thus preventing the occurrence of hemolysis.

[0047] The moving speed of the blood separation cylinder 30 corresponds to the speed at which the mixture passes through the filter medium 21. If, without using a screw connection, the user simply inserts the blood separation cylinder 30 by hand-pushing it, there is a possibility that the moving speed of the blood separation cylinder 30 becomes too fast and hemolysis may occur. In contrast, in the configuration of the present embodiment, since the screw connection between the lid member 50 and the screw portion 13 of the container body 10 is used to slowly push in the blood separation cylinder 30, blood can be separated well without causing the problem of hemolysis.

[0048] The insertion step of step S3 is performed until the blood separation cylinder 30 moves to the first position within the container body 10. Here, the "first position" is a state in which the flange portion 38a on the outer periphery of the blood separation cylinder 30 abuts against the upper end of the screw portion 13 of the container body 10 and the blood separation cylinder 30 cannot be pushed further into the container body 10.

[0049] Next, in step 4, the lid member 50 is further screwed in from the above state. In this state, since the movement of the blood separation cylinder 30 is restricted by the flange portion 38, as the lid member 50 rotates, the lid member 50 is strongly pressed against the blood separation cylinder 30.

[0050] When the lid member 50 is screwed in, as shown in FIG. 6(b), the inner surface 51a of the lid member 50 abuts against the stopper piece 35, and the stopper piece 35 is gradually plastically deformed. Specifically, as shown in FIG. 7, the stopper piece 35 is deformed such that a pair of protruding portions 35a fall inward in the radial direction (toward the center of the cylinder). Due to this deformation, the overall length of the blood separation cylinder 30 is shortened by the dimension h. Therefore, it becomes possible to move the lid member 50 toward the container body 10 by the dimension h (FIG. 7 shows a state where the stopper piece 35 has fallen halfway for easy understanding of the deformation. Finally, the stopper piece 35 may be configured to fall until it is almost at a right angle. In this case, it becomes possible to move the lid member 50 by a dimension h that is approximately the same as the height of the stopper piece 35).

[0051] In addition, the deformation of the stopper piece 35 may specifically be a mode in which only the support portion 35b is plastically deformed and the protruding portion 35a moves inward in the radial direction (the shape of the protruding portion 35a itself does not change), or a mode in which the stopper piece 35 gradually deforms while the protruding portion 35a itself also deforms (for example, the protruding portion 35a deforms so as to gradually bend inward in the radial direction from the top side). As the principle for the protruding portion 35a to fall inward in the radial direction, for example, it may be due to the top of the protruding portion 35a being pressed against the inner surface of the side wall of the lid member 50 and deforming. In addition, as the present invention, after the stopper piece 35 is pressed against the inner surface 51a of the lid member 50, one or both of the support portions 35b may be broken, and the protruding portion 35a may be crushed downward as it is. Specifically, the protruding portion 35a moves downward so as to enter the opening 37.

[0052] When the lid member 50 is screwed in while deforming the stopper piece 35 in this way, as shown in FIG. 7(b), the sealing plug 59 at the tip of the mandrel 57 moves to the through hole 31h, and finally, the sealing plug 59 is press-fitted into the through hole 31h, and the through hole 31h is closed (step S5, this position is referred to as the "second position"). By the steps up to this point, the separation and encapsulation of blood are completed.

[0053] In addition, in the configuration of the present embodiment, as described above, the partition wall 17 of the container body 10 is formed in a gently curved concave shape. Therefore, the amount (dead volume) of blood and buffer remaining in the separation membrane between the inner surface of the partition wall 17 and the filter material 21 at the tip of the cylinder 30 is reduced.

[0054] Next, in step S6, the blood separation device 1 is transported to an inspection center or the like. Then, in step S7, a medical staff member turns and removes the lid member 50 of the blood separation device 1. At this time, since the sealing plug 59 at the tip of the mandrel 57 is detached from the mandrel 57 and the state where the through hole 31h is closed is maintained, the blood remains separated. Thereafter, the blood cell components and the plasma or serum are analyzed using predetermined analytical instruments, respectively.

[0055] In the blood separation device 1 of the present embodiment described above, the stopper piece 35 formed at the upper end of the blood separation cylinder 30 has the function of (i) positioning the sealing plug 59 in front of the through hole 31h until the final stage of blood separation, and (ii) enabling the sealing plug 59 to move after blood separation and closing the through hole 31h. When the stopper piece 35 is plastically deformed, the through hole 31h can be closed by the sealing plug 59. However, since the stopper piece 35 is deformed slowly under the axial force from the lid member 50, fragments of the stopper piece 35 are less likely to occur. As a result, it is possible to prevent the fragments from mixing into the blood sample.

[0056] Further, since the stopper piece 35 is integrally formed on the upper end portion of the peripheral wall of the blood separation cylinder 30, the above-described functions can be realized with a simple structure.

[0057] In addition, due to the above structure, the blood separation cylinder of the present embodiment is relatively inexpensive, the operation of the user is simple, and the effect that the required amount of serum for inspection can be secured for a predetermined period with almost no individual differences can be obtained.

[0058] The present invention is not limited to the above-described embodiments and can be variously modified. For example, although there are only two stopper pieces 35 in the above embodiment, three or more stopper pieces 35 may be formed.

[0059] The shape of the top of the stopper piece 35 (see FIG. 3(b)) is not limited to a semicircular shape, and other shapes in which the width dimension gradually decreases as approaching the tip side may be used. For example, it may be triangular. Regarding the thickness of the stopper piece 35, for example, the thickness of the protruding portion 35a may be constant throughout, but it is not limited thereto. For example, the tip side of the protruding portion 35a may be formed to be thinner so that the tip side is more easily deformed.

[0060] The screw connection between the screw portion 13 of the container body 10 and the screw portion (not shown) of the lid member 50 may be configured such that, for example, the lid member 50 needs to be rotated four or more times (or 4.5 or more times) until the screw portions mesh and the lid member 50 is screwed to the fixed position. Also, although the pitch of the thread can be appropriately set according to the overall size of the product, it may be in the range of, for example, 0.5 mm to 1.5 mm. With such a configuration, when the lid member 50 is rotated, the blood separation cylinder 30 can be slowly advanced. Further, even if the lid member 50 becomes loose from the fixed position and rotates slightly for some reason, there is no possibility of leakage because a sufficient stroke is ensured until the position where the contents leak.

[0061] As described above, the present invention has been described using the embodiments. However, the technical scope of the present invention is not limited to the scope described in the above embodiments, and various modifications and changes are possible within the scope of the gist. For example, all or part of the device can be configured by functionally or physically dispersing and integrating it in any unit. Also, new embodiments generated by any combination of a plurality of embodiments are also included in the embodiments of the present invention. The effects of the new embodiments generated by the combination have the effects of the original embodiments combined.

Explanation of Reference Numerals

[0062] 1 Blood separation instrument 10 Container body 13 Screw portion 15 Accommodating portion 17 Partition wall 19 Rib 21 Filter material 30 Blood separation cylinder 31 Internal space 31h Through hole 32 Liquid component accommodating portion 33 Filter material accommodating portion 34 Annular protruding portion 34s Tapered surface 35 Stopper piece 35a Protrusion 35b Support portion 35h Through hole 37 Opening 38 Flange portion 42 Gasket 50 Cover member 51 Upper surface portion 51a Inner surface 52 Peripheral wall portion 53 Support portion 55 Cover body 55h Through hole 57 Mandrel 59 Sealing plug

Claims

1. A container body having a housing portion for housing blood collected from a subject, a blood separation cylinder that is formed in a cylindrical shape and has a filter material for separating blood provided therein, and is inserted into the housing portion from above, a lid member that is attached to the upper end portion of the container body by screwing in a state where the blood separation cylinder is inserted into the housing portion, and a blood separation device in which blood is separated by the filter material while the lid member is screwed in and the blood separation cylinder is inserted into the housing portion by being pushed by the lid member, wherein the lid member has a core rod with a sealing plug attached to the tip, the blood separation cylinder has a stopper piece that contacts the lid member when the lid member is screwed in, when the lid member is screwed in, the blood separation cylinder is inserted to a first position while being pushed by the lid member while maintaining the relative positional relationship in the axial direction between the core rod and the blood separation cylinder, when the lid member is further screwed in, the stopper piece plastically deforms, so that the core rod can move toward the inner side of the blood separation cylinder, and when the lid member is screwed to a fixed position, the sealing plug fits into a through hole in the blood separation cylinder and the through hole is configured to be closed, the stopper piece, a plate-like protruding portion that is a portion contacting the lid member, a support portion that connects the protruding portion and the cylindrical portion of the blood separation cylinder and is formed so as to preferentially deform when the stopper piece plastically deforms, and has, the top of the protruding portion is formed in a semi-circular shape when viewed in the thickness direction of the protruding portion, a blood separation device.

2. the blood separation cylinder has a cylindrical shape, the stopper piece is formed so as to protrude from the upper end portion of the blood separation cylinder toward the lid member side, The blood separation device according to claim 1.

3. a pair of the stopper pieces are provided, the first stopper piece and the second stopper piece are formed at intervals of 180° in the circumferential direction of the blood separation cylinder, The blood separation device according to claim 2.

4. the protruding portion of the stopper piece is configured to fall toward the inner side in the radial direction of the blood separation cylinder while the lid member is being screwed toward the fixed position, The blood separation device according to any one of claims 1 to 3.

5. The support portion is configured to break during the screwing of the lid member toward the fixed position, whereby the protruding amount of the protruding portion is reduced and the mandrel can move toward the inner side of the blood separation cylinder. The blood separation device according to any one of claims 1 to 3.

6. The screw connection between the screw portion of the container body and the screw portion of the lid member is configured such that the lid member needs to be rotated four or more times from when the screw portions engage until the lid member is screwed to the fixed position. The blood separation device according to any one of claims 1 to 5.

7. The sealing plug is configured to be disengaged from the mandrel when the lid member is rotated to pull out the mandrel after the sealing plug is once fitted into the through hole. The blood separation device according to any one of claims 1 to 6.

8. A container body having a storage portion for storing blood collected from a subject, A blood separation cylinder formed in a cylindrical shape, having a filtering material for separating blood provided therein, and inserted into the storage portion from above, A lid member attached to the upper end portion of the container body by screwing in a state where the blood separation cylinder is inserted into the storage portion, A blood separation device in which blood is separated by the filtering material while the blood separation cylinder is inserted into the storage portion by being pushed by the lid member as the lid member is screwed in, The lid member has a mandrel with a sealing plug attached to the tip, The blood separation cylinder has a stopper piece that abuts against the lid member when the lid member is screwed in, When the lid member is screwed in, the blood separation cylinder is inserted to the first position while being pushed by the lid member while maintaining the relative positional relationship in the axial direction between the mandrel and the blood separation cylinder, When the lid member is further screwed in, the stopper piece is plastically deformed, whereby the mandrel can move toward the inner side of the blood separation cylinder. When the lid member is screwed to the fixed position, the sealing plug is fitted into the through hole in the blood separation cylinder and the through hole is closed. The protruding portion of the stopper piece is configured to fall toward the inner side in the radial direction of the blood separation cylinder during the screwing of the lid member toward the fixed position. Blood separation device.

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