Breast cancer detection kit or device and detection method

Abstract

To provide breast cancer detection kits or devices and detection methods.SOLUTION: Provided is a breast cancer detection kit or device comprising nucleic acids capable of specifically binding to miRNA in a subject's sample, and methods for detecting breast cancer, comprising measuring the miRNA in vitro.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a kit or device for detecting breast cancer, which contains a nucleic acid that can specifically bind to a specific miRNA and is used for detecting the presence or absence of breast cancer in a subject, and a method for detecting breast cancer, which includes measuring the expression level of the miRNA using the nucleic acid.

Background Art

[0002] The breast is composed of mammary glands that produce breast milk, lobules that branch off from the mammary glands, milk ducts that carry milk and branch off from the lobules, and fat that supports them. Approximately 90% of breast cancers originate from the milk ducts, and approximately 5 to 10% of breast cancers originate from the lobules (Non-Patent Document 1). According to the statistics of cancer death rates by site in Japan in 2011 disclosed by the Cancer Information Center of the National Cancer Center, National Institutes of Biomedical Innovation, the number of breast cancer deaths reached 12,731, and it is said that one in 14 Japanese women is affected, making it the most common cancer site among women. In the United States, it is said that one in eight women develops breast cancer, and the estimated number of breast cancer patients in 2014 exceeded 232,670, of which approximately 40,000 are said to die (Non-Patent Document 1).

[0003] The progression of breast cancer is defined in Non-Patent Document 2 and is classified into stages 0, IA, IB, IIA, IIB, IIIA, IIIB, IIIC, and IV depending on the size of the tumor, invasiveness, lymph node metastasis, distant metastasis, etc. The 5-year relative survival rate of breast cancer greatly depends on the progression of the cancer and is reported to be 100% for stages 0 and 1, 93% for stage 2, 72% for stage 3, and 22% for stage 4 (Non-Patent Document 1). Therefore, for breast cancer ​​​​​​​​​​​​​​ Since early detection leads to improved survival rates, there is a strong desire to provide means to enable early detection.

[0004] The treatment of breast cancer is generally surgical, but depending on the degree of progression, metastasis, general condition, and classification of breast cancer, drug therapy and radiation therapy may be used in combination. In particular, for early breast cancer at stage 1 or 2, breast-conserving therapy may be selected in combination with radiation therapy in some cases (Non-Patent Document 1).

[0005] According to Non-Patent Document 1, primary examinations for breast cancer include, in addition to visual inspection and palpation, imaging examinations such as mammography, which is an X-ray examination dedicated to the breast, and ultrasonic (echo) examination. If findings suspicious of breast cancer are detected in the primary examination, a pathological examination is performed as a secondary examination by inserting a needle into the lesion to collect cells and tissues and examining them under a microscope. In addition, imaging examinations such as CT, MRI, abdominal ultrasound, bone scintigraphy, and PET may be performed as necessary to examine the state and spread of the lesion.

[0006] Tumor markers for breast cancer detection include, for example, CEA, CA-15-3, CA27- 29, etc. It has been reported that these blood tumor markers may increase when breast cancer metastasizes to other organs such as the bone and liver, but there are also some patients in whom they do not increase, and their usefulness is considered limited (Non-Patent Document 1).

[0007] Although still in the research stage, as shown in Patent Documents 1 to 4, by combining the expression level of microRNA (miRNA) in biological samples including blood, or the expression level of miRNA and the expression level of other protein markers, there are reports of detecting breast cancer.

[0008] ​​ Specifically, Patent Document 1 discloses a method for detecting other cancers including prostate cancer and breast cancer by combining hsa-miR-602 and hsa-miR-13 5a-3p in blood with known protein markers.

[0009] Patent Document 2 discloses a method for detecting various cancers including breast cancer by combining hsa-miR-23b-3p and hsa-miR-13 5a-3p in blood or tissues with five or more other miRNAs.

[0010] Patent Document 3 discloses a method for detecting breast cancer using hsa-miR-92a-3p, hsa-miR-92a -2-5p, hsa-miR-92b-5p, etc. in blood cells.

[0011] Patent Document 4 discloses a method for detecting breast cancer using hsa-miR-451a, hsa-miR-296-5p, hsa-miR-16-5p, etc. in tissues.

[0012] Non-Patent Document 3 shows that hsa-miR-760, etc. in blood are significantly expressed in breast cancer patients.

[0013] Non-Patent Document 4 shows that hsa-miR-423-5p, hsa-miR-486- 5p, etc. in blood decrease after breast cancer surgery.

[0014] Non-Patent Document 5 shows that hsa-miR-4257, hsa-miR-1915-3 p, hsa-miR-718, etc. in blood are significantly expressed in breast cancer patients.

[0015] Non-Patent Document 6 shows that hsa-miR-940 in blood is significantly expressed in breast cancer patients.

Prior Art Documents

Patent Documents

[0016]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Non-Patent Documents

[0017]

Non-Patent Document 1

Non-Patent Document 2

Non-Patent Document 3

Non-Patent Document 4

Non-Patent Document 5

Non-Patent Document 6

[0018] An object of the present invention is to find a novel breast cancer tumor marker and provide a method capable of effectively detecting breast cancer using a nucleic acid that can specifically bind to the marker. As described in Non-Patent Document 1 , for the primary examination of breast cancer, in addition to visual inspection and palpation, there are imaging examinations such as mammography, which is an X-ray examination dedicated to the breast, and ultrasonic examination. Mammography examination is considered effective as a breast cancer screening for women aged 40 and over, and the American Cancer Society recommends that women undergo it every year (Non-Patent Document 1). However, it is considered that mammography has limitations in detecting breast cancer existing in dense breasts before menopause and early-stage minute breast cancer (Non-Patent Document 1). In addition, in Japan, the acceptance rate of mammography examination was only 24.3% in 2010, and improving this acceptance rate is considered an issue for improving breast cancer survival rate (Non-Patent Document 7). (Non-Patent Document 1). For tumor markers for breast cancer detection, CEA, CA-15-3, CA27-2 9, etc. as described above are known. However, although these tumor markers may be useful for confirming the treatment effect of recurrent breast cancer, they rarely increase in early-stage breast cancer, so breast cancer

[0019]

[0019] It is considered not useful for the purpose of screening (Non-Patent Document 1). Also, according to Non-Patent Document 8 the specific sensitivities of CEA and CA15-3 are 6.4% and 12 .2% respectively at stage 1, which are hardly useful, and even at stage 4 they only remain at 25.0% and 62.5%. The significance of measuring tumor markers as a preoperative examination is poor. Also, since these blood tumor markers may increase for reasons other than breast cancer, it is difficult to determine the presence or absence of breast cancer. If another cancer is misdiagnosed as breast cancer, the opportunity for appropriate treatment may be missed, or inappropriate medical treatment may be applied, imposing unnecessary economic and physical burdens on the patient.

[0020] Also, although still in the research stage, there are reports of discriminating breast cancer using the expression levels of microRNA (miR NA) in biological samples including blood, but none of them have reached practical application.

[0021] Patent Document 1 shows a method of detecting other cancers including prostate cancer and breast cancer by combining hsa-miR-602 and hsa-miR-135a-3p in blood with known protein markers. However, measuring both miRNA and protein markers brings about an increase in inspection costs and procedural complexity, which is not desirable. Also, this detection method has no description regarding detection performance such as specific accuracy, sensitivity, and specificity for discriminating breast cancer, and has poor industrial practicality.

[0022] In Patent Document 2, hsa-miR-23b-3p and hsa-miR-13 5a-3p in blood or tissue are combined with five or more other miRNAs to detect various cancers including breast cancer. ​​​​Although a method is described, there is no description of the detection performance such as the specific accuracy, sensitivity, and specificity for discriminating breast cancer, and it has poor industrial applicability. There is no description of the detection performance such as the specific accuracy, sensitivity, and specificity for discriminating breast cancer, and it has poor industrial applicability.

[0023] In the method described in Patent Document 3, a method for detecting breast cancer using hsa-miR-92a-3p, hsa-miR-92 a-2-5p, hsa-miR-92b-5p, etc. is described. However, there is no description of the detection performance such as the specific accuracy, sensitivity, and specificity for discriminating breast cancer, and it has poor industrial applicability. Also, since the above miRNA markers have not been verified in an independent sample group, they lack reliability. There is no description of the detection performance such as the specific accuracy, sensitivity, and specificity for discriminating breast cancer, and it has poor industrial applicability. Also, since the above miRNA markers have not been verified in an independent sample group, they lack reliability. There is no description of the detection performance such as the specific accuracy, sensitivity, and specificity for discriminating breast cancer, and it has poor industrial applicability. Also, since the above miRNA markers have not been verified in an independent sample group, they lack reliability.

[0024] Patent Document 4 shows a method for detecting breast cancer using hsa-miR-451a, hsa-miR-296-5p, hsa-miR-16-5p, etc. in tissues. However, this detection method requires tissue resection by surgery to obtain samples, and this process imposes a heavy physical burden on patients, so it is not preferable as a detection method. Also, this detection method has no description of the detection performance such as the specific accuracy, sensitivity, and specificity for discriminating breast cancer, and it has poor industrial applicability. has no description of the detection performance such as the specific accuracy, sensitivity, and specificity for discriminating breast cancer, and it has poor industrial applicability.

[0025] Non-Patent Document 3 shows that hsa-miR-760, etc. in blood is significantly increased in breast cancer patients. However, there is no description of the detection performance such as the accuracy, sensitivity, and specificity for discriminating breast cancer, and also, no specific method for detecting breast cancer is described, so it has poor industrial applicability. also, no specific method for detecting breast cancer is described, so it has poor industrial applicability. also, no specific method for detecting breast cancer is described, so it has poor industrial applicability.

[0026] Non-Patent Document 4 shows that hsa-miR-423-5p, hsa-miR-486- 5p, etc. in blood decrease after breast cancer surgery. However, there is no description of the accuracy, sensitivity for discriminating breast cancer, There is no description of detection performance such as sensitivity and specificity, and no specific method for detecting breast cancer is described, so it has poor industrial applicability.

[0027] Non-Patent Document 5 shows that hsa-miR-4257, hsa-miR-1915-3p, hsa-miR-718, etc. in the blood are significantly expressed in breast cancer patients. However, 240 miRNAs are used to detect breast cancer, which raises concerns about increased test costs and the complexity of the discrimination algorithm, and it is not industrially practical.

[0028] Non-Patent Document 6 shows that hsa-miR-940 in the blood is significantly expressed in breast cancer patients. However, the author concludes that the reproducibility of this marker is poor and finally rejects it. Furthermore, there is no description of detection performance such as the accuracy, sensitivity, and specificity for discriminating breast cancer, and no specific method for detecting breast cancer is described, so it has poor industrial applicability.

[0029] Thus, in the detection of breast cancer, the performance of existing tumor markers is low, and for markers at the research stage, the performance and detection methods are not specifically shown. Therefore, when using these markers, there may be unnecessary additional examinations due to misdetecting healthy individuals as breast cancer patients, or missed treatment opportunities due to overlooking breast cancer patients. In addition, measuring dozens to hundreds of miRNAs increases the test cost, so it is difficult to use in large-scale screenings such as health check-ups. Furthermore, collecting breast tissue to measure tumor markers is highly invasive to patients and not preferable. Therefore, collecting samples with low invasiveness ​​​​​​​​​​​​​​It is possible to detect from blood, and there is a need for a highly accurate breast cancer marker that can correctly distinguish breast cancer patients from breast cancer patients and healthy individuals from healthy individuals. In particular, by detecting and treating breast cancer at an early stage, the risk of recurrence can be dramatically reduced, and breast-conserving therapy can also be made possible. Therefore, there is an urgent need for a breast cancer marker with high sensitivity that can detect even breast cancer with a low degree of progression. Furthermore, it is assumed that providing a simpler breast cancer primary screening test will lead to an improvement in the mammography attendance rate.

Means for Solving the Problems

[0030] 2-5p, miR-3184-5p, miR-6727-5p, miR-6088, mi R-4674, miR-8073, miR-4787-5p, miR-1469, miR -125a-3p, miR-1233-5p, miR-885-3p, miR-6802 -5p, miR-328-5p, miR-6787-5p, miR-8069, miR- <Summary of the Invention>

[0031] That is, the present invention has the following features. (1) Breast cancer markers miR-4783-3p, miR-4730, miR-1 307-3p, miR-4634, miR-663a, miR-4532, miR-77 04, miR-3178, miR-6729-5p, miR-6090, miR-473 2-5p, miR-3184-5p, miR-6727-5p, miR-6088, mi R-4674, miR-8073, miR-4787-5p, miR-1469, miR -125a-3p, miR-1233-5p, miR-885-3p, miR-6802 -5p, miR-328-5p, miR-6787-5p, miR-8069, miR- 6875-5p, miR-1246, miR-4734, miR-6757-5p, mi R-6756-5p, miR-3665, miR-6836-3p, miR-6821- 5p, miR-6805-5p, miR-4728-5p, miR-6726-5p, m iR-197-5p, miR-149-3p, miR-6850-5p, miR-447 6, miR-6858-5p, miR-564, miR-4763-3p, miR-57 5, miR-6771-5p, miR-1231, miR-1908-3p, miR-1 50-3p, miR-3937, miR-887-3p, miR-3940-5p, mi R-4741, miR-6808-5p, miR-6869-5p, miR-5090, miR-615-5p, miR-8072, miR-128-1-5p, miR-123 8-5p, miR-365a-5p, miR-204-3p, miR-4492, miR -6785-5p, miR-6511a-5p, miR-4525, miR-1915- 5p, miR-3180, miR-6879-5p, miR-1199-5p, miR- 6746-5p, miR-711, miR-663b, miR-4707-3p, miR -6893-5p, miR-4675, miR-4638-5p, miR-4651, m iR-6087, miR-4665-5p, miR-4758-5p, miR-6887 -5p, miR-3620-5p, miR-1909-3p, miR-7641, miR -6724-5p, miR-1343-3p, miR-6780b-5p, miR-44 84, miR-4690-5p, miR-4429, miR-1227-5p, miR- 4725-3p, miR-6861-5p, miR-6812-5p, miR-3197 , miR-8059, miR-3185, miR-4706, miR-4497, miR -3131, miR-6806-5p, miR-187-5p, miR-3180-3p , miR-6848-5p, miR-6820-5p, miR-6800-5p, miR -6717-5p, miR-6795-5p, miR-4632-5p, miR-665 , miR-6778-5p, miR-3663-3p, miR-4689, miR-21 1-3p, miR-6511b-5p, miR-4750-5p, miR-6126, m iR-614, miR-7110-5p, miR-744-5p, miR-6769a- 5p, miR-4792, miR-5787, miR-6798-5p, miR-678 1-5p, miR-4419b, miR-4446-3p, miR-4259, miR- 5572, miR-6075, miR-296-3p, miR-6891-5p, miR -4745-5p, miR-6775-5p, miR-6870-5p, miR-920 , miR-4530, miR-6819-5p, miR-6825-5p, miR-78 47-3p, miR-6131, miR-4433-3p, miR-1228-5p, m iR-6743-5p, miR-1268a, miR-3917, miR-6786-5 p, miR-3154, miR-638, miR-6741-5p, miR-6889- 5p, miR-6840-3p, miR-6510-5p, miR-3188, miR- 551b-5p, miR-5001-5p, miR-1268b, miR-7107-5 p, miR-6824-5p, miR-6732-5p, miR-371a-5p, mi R-6794-5p, miR-6779-5p, miR-4271, miR-5195- 3p, miR-6762-5p, miR-939-5p, miR-1247-3p, mi R-6777-5p, miR-6722-3p, miR-3656, miR-4688, miR-3195, miR-6766-5p, miR-4447, miR-4656, m iR-7108-5p, miR-3191-3p, miR-1273g-3p, miR- 4463, miR-2861, miR-3196, miR-6877-5p, miR-3 679-5p, miR-4442, miR-6789-5p, miR-6782-5p, miR-486-3p, miR-6085, miR-4746-3p, miR-619- 5p, miR-937-5p, miR-6803-5p, miR-4298, miR-4 454, miR-4459, miR-7150, miR-6880-5p, miR-44 49, miR-8063, miR-4695-5p, miR-6132, miR-682 9-5p, miR-4486, miR-6805-3p, miR-6826-5p, mi R-4508, miR-1343-5p, miR-7114-5p, miR-3622a -5p, miR-6765-5p, miR-7845-5p, miR-3960, miR -6749-5p, miR-1260b, miR-6799-5p, miR-4723- 5p, miR-6784-5p, miR-5100, miR-6769b-5p, miR -1207-5p, miR-642a-3p, miR-4505, miR-4270, m iR-6721-5p, miR-7111-5p, miR-6791-5p, miR-7 109-5p, miR-4258, miR-6515-3p, miR-6851-5p, miR-6125, miR-4749-5p, miR-4726-5p, miR-451 3, miR-6089, miR-6816-5p, miR-4466, miR-4488 and at least 1 selected from the group consisting of miR-6752-5p and miR-4739 A kit for detecting breast cancer, comprising a nucleic acid capable of specifically binding to at least one polynucleotide selected from the group consisting of miR-6125, miR-4749-5p, miR-4726-5p, miR-451, 3, miR-6089, miR-6816-5p, miR-4466, miR-4488, miR-6752-5p and miR-4739.

[0032] (2) miR-4783-3p is hsa-miR-4783-3p, miR-47 30 is hsa-miR-4730, miR-1307-3p is hsa-miR-1 307-3p, miR-4634 is hsa-miR-4634, miR-6 63a is hsa-miR-663a, miR-4532 is hsa-miR-453 2, miR-7704 is hsa-miR-7704, miR-3178 is h sa-miR-3178, miR-6729-5p is hsa-miR-6729- 5p, miR-6090 is hsa-miR-6090, miR-4732- 5p is hsa-miR-4732-5p, miR-3184-5p is hsa-mi R-3184-5p, miR-6727-5p is hsa-miR-6727-5p and miR-6088 is hsa-miR-6088, miR-4674 is hs a-miR-4674, miR-8073 is hsa-miR-8073, m iR-4787-5p is hsa-miR-4787-5p, miR-1469 is h sa-miR-1469, miR-125a-3p is hsa-miR-125a- 3p, miR-1233-5p is hsa-miR-1233-5p, miR -885-3p is hsa-miR-885-3p, and miR-6802-5p is hs a-miR-6802-5p, and miR-328-5p is hsa-miR-328- 5p, and miR-6787-5p is hsa-miR-6787-5p, and miR -8069 is hsa-miR-8069, and miR-6875-5p is hsa-mi R-6875-5p, and miR-1246 is hsa-miR-1246, and mi R-4734 is hsa-miR-4734, and miR-6757-5p is hsa-m iR-6757-5p, and miR-6756-5p is hsa-miR-6756-5 p, and miR-3665 is hsa-miR-3665, and miR-6836-3 p is hsa-miR-6836-3p, and miR-6821-5p is hsa-miR -6821-5p, and miR-6805-5p is hsa-miR-6805-5p, and miR-4728-5p is hsa-miR-4728-5p, and miR-67 26-5p is hsa-miR-6726-5p, and miR-197-5p is hsa- miR-197-5p, and miR-149-3p is hsa-miR-149-3p, and miR-6850-5p is hsa-miR-6850-5p, and miR-44 76 is hsa-miR-4476, and miR-6858-5p is hsa-miR-6 858-5p, and miR-564 is hsa-miR-564, and miR-476 3-3p is hsa-miR-4763-3p, and miR-575 is hsa-miR- 575, and miR-6771-5p is hsa-miR-6771-5p, and mi R-1231 is hsa-miR-1231, and miR-1908-3p is hsa-m iR-1908-3p, where miR-150-3p is hsa-miR-150-3p and miR-3937 is hsa-miR-3937, and miR-887-3p is h sa-miR-887-3p, and miR-3940-5p is hsa-miR-394 0-5p, and miR-4741 is hsa-miR-4741, and miR-680 8-5p is hsa-miR-6808-5p, and miR-6869-5p is hsa- miR-6869-5p, and miR-5090 is hsa-miR-5090, and miR-615-5p is hsa-miR-615-5p, and miR-8072 is hs a-miR-8072, and miR-128-1-5p is hsa-miR-128-1 -5p, and miR-1238-5p is hsa-miR-1238-5p, and mi R-365a-5p is hsa-miR-365a-5p, and miR-204-3p is hsa-miR-204-3p, and miR-4492 is hsa-miR-4492 and miR-6785-5p is hsa-miR-6785-5p, and miR-65 11a-5p is hsa-miR-6511a-5p, and miR-4525 is hsa- miR-4525, and miR-1915-5p is hsa-miR-1915-5p and miR-3180 is hsa-miR-3180, and miR-6879-5p is hsa-miR-6879-5p, and miR-1199-5p is hsa-miR-1 199-5p, and miR-6746-5p is hsa-miR-6746-5p and miR-711 is hsa-miR-711, and miR-663b is hsa-miR -663b, where miR-4707-3p is hsa-miR-4707-3p, miR-6893-5p is hsa-miR-6893-5p, and miR-4675 is hsa-miR-4675, miR-4638-5p is hsa-miR-4638 -5p, miR-4651 is hsa-miR-4651, miR-6087 is hsa-miR-6087, miR-4665-5p is hsa-miR-466 5-5p, miR-4758-5p is hsa-miR-4758-5p, m iR-6887-5p is hsa-miR-6887-5p, miR-3620-5 p is hsa-miR-3620-5p, miR-1909-3p is hsa-miR -1909-3p, miR-7641 is hsa-miR-7641, miR -6724-5p is hsa-miR-6724-5p, miR-1343-3p is hsa-miR-1343-3p, miR-6780b-5p is hsa-miR- 6780b-5p, miR-4484 is hsa-miR-4484, miR -4690-5p is hsa-miR-4690-5p, miR-4429 is hsa -miR-4429, miR-1227-5p is hsa-miR-1227-5p and miR-4725-3p is hsa-miR-4725-3p, miR-6 861-5p is hsa-miR-6861-5p, miR-6812-5p is hs a-miR-6812-5p, miR-3197 is hsa-miR-3197 and miR-8059 is hsa-miR-8059, miR-3185 is hsa- miR-3185, miR-4706 is hsa-miR-4706, miR -4497 is hsa-miR-4497, miR-3131 is hsa-miR-3 131, miR-6806-5p is hsa-miR-6806-5p, mi R-187-5p is hsa-miR-187-5p, miR-3180-3p is h sa-miR-3180-3p, miR-6848-5p is hsa-miR-68 48-5p, miR-6820-5p is hsa-miR-6820-5p, miR-6800-5p is hsa-miR-6800-5p, miR-6717- 5p is hsa-miR-6717-5p, miR-6795-5p is hsa-mi R-6795-5p, miR-4632-5p is hsa-miR-4632-5p miR-665 is hsa-miR-665, miR-6778-5p is h sa-miR-6778-5p, miR-3663-3p is hsa-miR-36 63-3p, miR-4689 is hsa-miR-4689, miR-21 1-3p is hsa-miR-211-3p, miR-6511b-5p is hsa- miR-6511b-5p, miR-4750-5p is hsa-miR-4750 -5p, miR-6126 is hsa-miR-6126, miR-614 is hsa-miR-614, miR-7110-5p is hsa-miR-7110- 5p, miR-744-5p is hsa-miR-744-5p, miR-6 769a-5p is hsa-miR-6769a-5p, miR-4792 is hsa -miR-4792, miR-5787 is hsa-miR-5787, mi R-6798-5p is hsa-miR-6798-5p, miR-6781-5p is hsa-miR-6781-5p, miR-4419b is hsa-miR-4419b, miR-4446-3p R-4259 is hsa-miR-4259, miR-5572 is hsa-miR-5572, miR-6075 -3p is hsa-miR-296-3p, miR-6891-5p is hsa-miR-6891-5p, miR-4745-5p is hsa-miR-4745-5p, miR-6775-5p is hsa-miR-6775-5p, miR-6870-5p is hsa-miR-920, miR-4530 -5p is hsa-miR-6819-5p, miR-6825-5p is hsa-miR-6825-5p, miR-7847-3p is hsa-miR-7847-3p, miR-6131 -3p is hsa-miR-4433-3p, miR-1228-5p is hsa-miR-1228-5p, miR-6743-5p is hsa-miR-6743-5p, miR-1268a is hsa-miR-3917, miR-6786-5p is hsa-miR-6786-5p, miR-3154 is hsa-miR-638, miR-6741-5p -5p, where miR-6889-5p is hsa-miR-6889-5p, and mi R-6840-3p is hsa-miR-6840-3p, and miR-6510-5p is hsa-miR-6510-5p, and miR-3188 is hsa-miR-318 8, and miR-551b-5p is hsa-miR-551b-5p, and miR- 5001-5p is hsa-miR-5001-5p, and miR-1268b is hsa -miR-1268b, and miR-7107-5p is hsa-miR-7107-5 p, and miR-6824-5p is hsa-miR-6824-5p, and miR- 6732-5p is hsa-miR-6732-5p, and miR-371a-5p is h sa-miR-371a-5p, and miR-6794-5p is hsa-miR-67 94-5p, and miR-6779-5p is hsa-miR-6779-5p, and miR-4271 is hsa-miR-4271, and miR-5195-3p is hsa -miR-5195-3p, and miR-6762-5p is hsa-miR-6762 -5p, and miR-939-5p is hsa-miR-939-5p, and miR- 1247-3p is hsa-miR-1247-3p, and miR-6777-5p is h sa-miR-6777-5p, and miR-6722-3p is hsa-miR-67 22-3p, and miR-3656 is hsa-miR-3656, and miR-46 88 is hsa-miR-4688, and miR-3195 is hsa-miR-3195 and miR-6766-5p is hsa-miR-6766-5p, and miR-4 447 is hsa-miR-4447, miR-4656 is hsa-miR-465 6, miR-7108-5p is hsa-miR-7108-5p, miR- 3191-3p is hsa-miR-3191-3p, miR-1273g-3p is hsa-miR-1273g-3p, miR-4463 is hsa-miR-446 3, miR-2861 is hsa-miR-2861, miR-3196 is h sa-miR-3196, miR-6877-5p is hsa-miR-6877- 5p, miR-3679-5p is hsa-miR-3679-5p, miR -4442 is hsa-miR-4442, miR-6789-5p is hsa-mi R-6789-5p, miR-6782-5p is hsa-miR-6782-5p , miR-486-3p is hsa-miR-486-3p, miR-608 5 is hsa-miR-6085, miR-4746-3p is hsa-miR-47 46-3p, miR-619-5p is hsa-miR-619-5p, mi R-937-5p is hsa-miR-937-5p, miR-6803-5p is h sa-miR-6803-5p, miR-4298 is hsa-miR-4298 , miR-4454 is hsa-miR-4454, miR-4459 is hsa -miR-4459, miR-7150 is hsa-miR-7150, mi R-6880-5p is hsa-miR-6880-5p, miR-4449 is hs a-miR-4449, miR-8063 is hsa-miR-8063, m iR-4695-5p is hsa-miR-4695-5p, miR-6132 is h sa-miR-6132, where miR-6829-5p is hsa-miR-6829- 5p, miR-4486 is hsa-miR-4486, miR-6805- 3p is hsa-miR-6805-3p, miR-6826-5p is hsa-mi R-6826-5p, miR-4508 is hsa-miR-4508, mi R-1343-5p is hsa-miR-1343-5p, miR-7114-5p is hsa-miR-7114-5p, miR-3622a-5p is hsa-miR -3622a-5p, miR-6765-5p is hsa-miR-6765-5p , miR-7845-5p is hsa-miR-7845-5p, miR-3 960 is hsa-miR-3960, miR-6749-5p is hsa-miR- 6749-5p, miR-1260b is hsa-miR-1260b, mi R-6799-5p is hsa-miR-6799-5p, miR-4723-5p is hsa-miR-4723-5p, miR-6784-5p is hsa-miR- 6784-5p, miR-5100 is hsa-miR-5100, miR- 6769b-5p is hsa-miR-6769b-5p, miR-1207-5p is hsa-miR-1207-5p, miR-642a-3p is hsa-miR- 642a-3p, miR-4505 is hsa-miR-4505, miR- 4270 is hsa-miR-4270, miR-6721-5p is hsa-miR -6721-5p, miR-7111-5p is hsa-miR-7111-5p, de Yes, miR-6791-5p is hsa-miR-6791-5p, miR-71 09-5p is hsa-miR-7109-5p, miR-4258 is hsa-mi R-4258, miR-6515-3p is hsa-miR-6515-3p , miR-6851-5p is hsa-miR-6851-5p, miR-6125 is hsa-miR-6125, miR-4749-5p is hsa-miR-474 9-5p, miR-4726-5p is hsa-miR-4726-5p, m iR-4513 is hsa-miR-4513, miR-6089 is hsa-miR -6089, miR-6816-5p is hsa-miR-6816-5p, miR-4466 is hsa-miR-4466, miR-4488 is hsa-mi R-4488, miR-6752-5p is hsa-miR-6752-5p , and miR-4739 is hsa-miR-4739, the kit according to (1).

[0033] (3) The nucleic acid is a polynucleotide represented by any of the following (a) to (e): (a) A polynucleotide consisting of a base sequence represented by any of SEQ ID NOs: 1 to 235 and 851 to 856 or a base sequence in which u is t in the base sequence, a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, (b) A polynucleotide containing a base sequence represented by any of SEQ ID NOs: 1 to 235 and 851 to 856 or a base sequence in which u is t in the base sequence, (c) A polynucleotide consisting of a base sequence complementary to a base sequence represented by any of SEQ ID NOs: 1 to 235 and 851 to 856 or a base sequence in which u is t in the base sequence (d) A polynucleotide containing a base sequence complementary to a base sequence represented by any of SEQ ID NOs: 1 to 235 and 851 to 856 or a base sequence in which u is t in the base sequence, (e) A polynucleotide containing a base sequence complementary to a base sequence represented by any of SEQ ID NOs: 1 to 235 and 851 to 856 or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases, , its variant, its derivative, or a fragment thereof containing 15 or more consecutive bases, (d) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 1 to 235 and 851 to 856, or a base sequence complementary to the base sequence in which u is t in the said base sequence, and (e) a polynucleotide that hybridizes under stringent conditions with any of the polynucleotides of (a) to (d) above, The kit according to (1) or (2), which is a polynucleotide selected from the group consisting of .

[0034] (4) The kit further comprises a nucleic acid that can specifically bind to at least one polynucleotide selected from the group consisting of miR-760, miR-602, miR R-423-5p, miR-92a-2-5p, miR-16-5p, miR-451a , miR-135a-3p, miR-486-5p, miR-4257, miR-92b -5p, miR-1915-3p, miR-718, miR-940, miR-296- 5p, miR-23b-3p, and miR-92a-3p, which are another breast cancer marker. The kit according to any of (1) to (3).

[0035] (5) miR-760 is hsa-miR-760, miR-602 is hsa-mi R-602, miR-423-5p is hsa-miR-423-5p, miR R-92a-2-5p is hsa-miR-92a-2-5p, miR-16-5p is hsa-miR-16-5p, miR-451a is hsa-miR-451a where, miR-135a-3p is hsa-miR-135a-3p, miR-48 6-5p is hsa-miR-486-5p, miR-4257 is hsa-miR- 4257, miR-92b-5p is hsa-miR-92b-5p, miR -1915-3p is hsa-miR-1915-3p, miR-718 is hsa- miR-718, miR-940 is hsa-miR-940, miR-29 6-5p is hsa-miR-296-5p, miR-23b-3p is hsa-mi R-23b-3p, and miR-92a-3p is hsa-miR-92a-3p as described in (4). The kit according to (4).

[0036] (6) The nucleic acid is a polynucleotide represented by any of the following (f) to (j): (f) A polynucleotide consisting of a base sequence represented by any of SEQ ID NOs: 236 to 251 or a base sequence in which u is t in the base sequence, a variant thereof, a derivative thereof, or a fragment thereof containing 1 5 or more consecutive bases, (g) A polynucleotide containing a base sequence represented by any of SEQ ID NOs: 236 to 251,(h) A polynucleotide consisting of a base sequence complementary to the base sequence represented by any of SEQ ID NOs: 236 to 251 or a base sequence in which u is t in the base sequence, a variant thereof, (i) A polynucleotide containing a base sequence complementary to the base sequence represented by any of SEQ ID NOs: 236 to 251 or a base sequence in which u is t in the base sequence, and (j) A polynucleotide that hybridizes with any of the polynucleotides of (f) to (i) under stringent conditions, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, (i) A polynucleotide containing a base sequence complementary to the base sequence represented by any of SEQ ID NOs: 236 to 251 or a base sequence in which u is t in the base sequence, and (j) A polynucleotide that hybridizes with any of the polynucleotides of (f) to (i) under stringent conditions,(j) A polynucleotide that hybridizes with any of the polynucleotides of (f) to (i) under stringent conditions, The kit according to (4) or (5), which is a polynucleotide selected from the group consisting of

[0037] ​ (7) The kit is miR-658, miR-6842-5p, which are other breast cancer markers p, miR-6124, miR-6765-3p, miR-7106-5p, miR-4 534, miR-92b-3p, miR-3135b, miR-4687-3p, miR -762, miR-3619-3p, miR-4467, miR-557, miR-12 37-5p, miR-1908-5p, miR-4286, miR-6885-5p, and at least one polynucleotide selected from the group consisting of miR-6763-5p, and a nucleic acid that can specifically bind thereto, the kit according to any one of (1) to (6).

[0038] (8) miR-658 is hsa-miR-658, miR-6842-5p is hs a-miR-6842-5p, miR-6124 is hsa-miR-6124 and, miR-6765-3p is hsa-miR-6765-3p, miR-710 6-5p is hsa-miR-7106-5p, miR-4534 is hsa-miR -4534, miR-92b-3p is hsa-miR-92b-3p, mi R-3135b is hsa-miR-3135b, miR-4687-3p is hsa -miR-4687-3p, miR-762 is hsa-miR-762, m iR-3619-3p is hsa-miR-3619-3p, miR-4467 is h sa-miR-4467, miR-557 is hsa-miR-557, mi R-1237-5p is hsa-miR-1237-5p, miR-1908-5p is hsa-miR-1908-5p, miR-4286 is hsa-miR-428 is 6, miR-6885-5p is hsa-miR-6885-5p, and m iR-6763-5p is hsa-miR-6763-5p, the kit according to (7) .

[0039] (9) The nucleic acid is a polynucleotide represented by the following (k) to (o): (k) A polynucleotide consisting of a base sequence represented by any of SEQ ID NOs: 252 to 269 or a base sequence in which u is t in the base sequence, a variant thereof, a derivative thereof, or a fragment thereof containing 1 5 or more consecutive bases, (l) A polynucleotide containing a base sequence represented by any of SEQ ID NOs: 252 to 269, (m) A polynucleotide consisting of a base sequence complementary to the base sequence represented by any of SEQ ID NOs: 252 to 269 or a base sequence in which u is t in the base sequence, a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, (n) A polynucleotide containing a base sequence complementary to the base sequence represented by any of SEQ ID NOs: 252 to 269 or a base sequence in which u is t in the base sequence, and (o) A polynucleotide that hybridizes with any of the polynucleotides of (k) to (n) under stringent conditions, The kit according to (7) or (8), which is a polynucleotide selected from the group consisting of . (10) The kit is capable of specifically binding to each of at least two polynucleotides selected from the group consisting of all the breast cancer markers described in (1) or (2). The kit according to any of (1) to (9), which contains at least two nucleic acids.

[0040] (10) The kit contains at least two nucleic acids that can specifically bind to each of at least two polynucleotides selected from the group consisting of all the breast cancer markers described in (1) or (2). The kit according to any of (1) to (9).

[0041] ​(11) miR-4783-3p, miR-4730, miR- 1307-3p, miR-4634, miR-663a, miR-4532, miR-7 704, miR-3178, miR-6729-5p, miR-6090, miR-47 32-5p, miR-3184-5p, miR-6727-5p, miR-6088, m iR-4674, miR-8073, miR-4787-5p, miR-1469, mi R-125a-3p, miR-1233-5p, miR-885-3p, miR-680 2-5p, miR-328-5p, miR-6787-5p, miR-8069, miR -6875-5p, miR-1246, miR-4734, miR-6757-5p, m iR-6756-5p, miR-3665, miR-6836-3p, miR-6821 -5p, miR-6805-5p, miR-4728-5p, miR-6726-5p, miR-197-5p, miR-149-3p, miR-6850-5p, miR-44 76, miR-6858-5p, miR-564, miR-4763-3p, miR-5 75, miR-6771-5p, miR-1231, miR-1908-3p, miR- 150-3p, miR-3937, miR-887-3p, miR-3940-5p, m iR-4741, miR-6808-5p, miR-6869-5p, miR-5090 , miR-615-5p, miR-8072, miR-128-1-5p, miR-12 38-5p, miR-365a-5p, miR-204-3p, miR-4492, mi R-6785-5p, miR-6511a-5p, miR-4525, miR-1915 -5p, miR-3180, miR-6879-5p, miR-1199-5p, miR -6746-5p, miR-711, miR-663b, miR-4707-3p, mi R-6893-5p, miR-4675, miR-4638-5p, miR-4651, miR-6087, miR-4665-5p, miR-4758-5p, miR-688 7-5p, miR-3620-5p, miR-1909-3p, miR-7641, mi R-6724-5p, miR-1343-3p, miR-6780b-5p, miR-4 484, miR-4690-5p, miR-4429, miR-1227-5p, miR -4725-3p, miR-6861-5p, miR-6812-5p, miR-319 7, miR-8059, miR-3185, miR-4706, miR-4497, mi R-3131, miR-6806-5p, miR-187-5p, miR-3180-3 p, miR-6848-5p, miR-6820-5p, miR-6800-5p, mi R-6717-5p, miR-6795-5p, miR-4632-5p, miR-66 5, miR-6778-5p, miR-3663-3p, miR-4689, miR-2 11-3p, miR-6511b-5p, miR-4750-5p, miR-6126, miR-614, miR-7110-5p, miR-744-5p, miR-6769a -5p, miR-4792, miR-5787, miR-6798-5p, miR-67 81-5p, miR-4419b, miR-4446-3p, miR-4259, miR -5572, miR-6075, miR-296-3p, miR-6891-5p, mi R-4745-5p, miR-6775-5p, miR-6870-5p, miR-92 0, miR-4530, miR-6819-5p, miR-6825-5p, miR-7 847-3p, miR-6131, miR-4433-3p, miR-1228-5p, miR-6743-5p, miR-1268a, miR-3917, miR-6786- 5p, miR-3154, miR-638, miR-6741-5p, miR-6889 -5p, miR-6840-3p, miR-6510-5p, miR-3188, miR -551b-5p, miR-5001-5p, miR-1268b, miR-7107- 5p, miR-6824-5p, miR-6732-5p, miR-371a-5p, m iR-6794-5p, miR-6779-5p, miR-4271, miR-5195 -3p, miR-6762-5p, miR-939-5p, miR-1247-3p, m iR-6777-5p, miR-6722-3p, miR-3656, miR-4688 , miR-3195, miR-6766-5p, miR-4447, miR-4656, miR-7108-5p, miR-3191-3p, miR-1273g-3p, miR -4463, miR-2861, miR-3196, miR-6877-5p, miR- 3679-5p, miR-4442, miR-6789-5p, miR-6782-5p , miR-486-3p, miR-6085, miR-4746-3p, miR-619 -5p, miR-937-5p, miR-6803-5p, miR-4298, miR- 4454, miR-4459, miR-7150, miR-6880-5p, miR-4 449, miR-8063, miR-4695-5p, miR-6132, miR-68 29-5p, miR-4486, miR-6805-3p, miR-6826-5p, m iR-4508, miR-1343-5p, miR-7114-5p, miR-3622 a-5p, miR-6765-5p, miR-7845-5p, miR-3960, mi R-6749-5p, miR-1260b, miR-6799-5p, miR-4723 -5p, miR-6784-5p, miR-5100, miR-6769b-5p, mi R-1207-5p, miR-642a-3p, miR-4505, miR-4270, miR-6721-5p, miR-7111-5p, miR-6791-5p, miR- 7109-5p, miR-4258, miR-6515-3p, miR-6851-5p , miR-6125, miR-4749-5p, miR-4726-5p, miR-45 13, miR-6089, miR-6816-5p, miR-4466, miR-448 8. At least one selected from the group consisting of miR-6752-5p and miR-4739 A device for detecting breast cancer, comprising a nucleic acid capable of specifically binding to one polynucleotide.

[0042] (12) miR-4783-3p is hsa-miR-4783-3p, and miR-4 730 is hsa-miR-4730, and miR-1307-3p is hsa-miR- 1307-3p, miR-4634 is hsa-miR-4634, and miR- 663a is hsa-miR-663a and miR-4532 is hsa-miR-45 32, miR-7704 is hsa-miR-7704, and miR-3178 is hsa-miR-3178 and miR-6729-5p are hsa-miR-6729 -5p, miR-6090 is hsa-miR-6090, and miR-4732 -5p is hsa-miR-4732-5p, miR-3184-5p is hsa-m iR-3184-5p, miR-6727-5p is hsa-miR-6727-5 p, miR-6088 is hsa-miR-6088, miR-4674 is h sa-miR-4674, miR-8073 is hsa-miR-8073, miR-4787-5p is hsa-miR-4787-5p, miR-1469 is hsa-miR-1469, miR-125a-3p is hsa-miR-125a -3p, miR-1233-5p is hsa-miR-1233-5p, mi R-885-3p is hsa-miR-885-3p, miR-6802-5p is h sa-miR-6802-5p, miR-328-5p is hsa-miR-328 -5p, miR-6787-5p is hsa-miR-6787-5p, mi R-8069 is hsa-miR-8069, miR-6875-5p is hsa-m iR-6875-5p, miR-1246 is hsa-miR-1246, m iR-4734 is hsa-miR-4734, miR-6757-5p is hsa- miR-6757-5p, miR-6756-5p is hsa-miR-6756- 5p, miR-3665 is hsa-miR-3665, miR-6836- 3p is hsa-miR-6836-3p, miR-6821-5p is hsa-mi R-6821-5p, miR-6805-5p is hsa-miR-6805-5p , miR-4728-5p is hsa-miR-4728-5p, miR-6 726-5p is hsa-miR-6726-5p, miR-197-5p is hsa -miR-197-5p, where miR-149-3p is hsa-miR-149-3p where miR-6850-5p is hsa-miR-6850-5p, and miR-4 476 is hsa-miR-4476, and miR-6858-5p is hsa- 6858-5p, miR-564 is hsa-miR-564, and miR-47 63-3p is hsa-miR-4763-3p, and miR-575 is hsa-miR -575, miR-6771-5p is hsa-miR-6771-5p, and m iR-1231 is hsa-miR-1231, and miR-1908-3p is hsa- miR-1908-3p, miR-150-3p is hsa-miR-150-3p where miR-3937 is hsa-miR-3937, and miR-887-3p is hsa-miR-887-3p, and miR-3940-5p is hsa-miR-39 40-5p, miR-4741 is hsa-miR-4741, and miR-68 08-5p is hsa-miR-6808-5p, and miR-6869-5p is hsa -miR-6869-5p, miR-5090 is hsa-miR-5090, and miR-615-5p is hsa-miR-615-5p, and miR-8072 is h sa-miR-8072, miR-128-1-5p is hsa-miR-128- 1-5p, miR-1238-5p is hsa-miR-1238-5p, and m iR-365a-5p is hsa-miR-365a-5p, and miR-204-3p is hsa-miR-204-3p, and miR-4492 is hsa-miR-4492 and miR-6785-5p is hsa-miR-6785-5p, miR-6 511a-5p is hsa-miR-6511a-5p, miR-4525 is hsa -miR-4525, miR-1915-5p is hsa-miR-1915-5p and miR-3180 is hsa-miR-3180, miR-6879-5p is hsa-miR-6879-5p, miR-1199-5p is hsa-miR- 1199-5p, miR-6746-5p is hsa-miR-6746-5p and miR-711 is hsa-miR-711, miR-663b is hsa-mi R-663b, miR-4707-3p is hsa-miR-4707-3p and miR-6893-5p is hsa-miR-6893-5p, miR-4675 is hsa-miR-4675, miR-4638-5p is hsa-miR-463 8-5p, miR-4651 is hsa-miR-4651, miR-608 7 is hsa-miR-6087, miR-4665-5p is hsa-miR-46 65-5p, miR-4758-5p is hsa-miR-4758-5p, miR-6887-5p is hsa-miR-6887-5p, miR-3620- 5p is hsa-miR-3620-5p, miR-1909-3p is hsa-mi R-1909-3p, miR-7641 is hsa-miR-7641, mi R-6724-5p is hsa-miR-6724-5p, miR-1343-3p is hsa-miR-1343-3p, miR-6780b-5p is hsa-miR -6780b-5p, miR-4484 is hsa-miR-4484, mi R-4690-5p is hsa-miR-4690-5p, and miR-4429 is hs a-miR-4429, and miR-1227-5p is hsa-miR-1227-5 p, and miR-4725-3p is hsa-miR-4725-3p, and miR- 6861-5p is hsa-miR-6861-5p, and miR-6812-5p is h sa-miR-6812-5p, and miR-3197 is hsa-miR-3197 and miR-8059 is hsa-miR-8059, and miR-3185 is hsa -miR-3185, and miR-4706 is hsa-miR-4706, and mi R-4497 is hsa-miR-4497, and miR-3131 is hsa-miR- 3131, and miR-6806-5p is hsa-miR-6806-5p, and m iR-187-5p is hsa-miR-187-5p, and miR-3180-3p is hsa-miR-3180-3p, and miR-6848-5p is hsa-miR-6 848-5p, and miR-6820-5p is hsa-miR-6820-5p and miR-6800-5p is hsa-miR-6800-5p, and miR-6717 -5p is hsa-miR-6717-5p, and miR-6795-5p is hsa-m iR-6795-5p, and miR-4632-5p is hsa-miR-4632-5 p, and miR-665 is hsa-miR-665, and miR-6778-5p is hsa-miR-6778-5p, and miR-3663-3p is hsa-miR-3 663-3p, and miR-4689 is hsa-miR-4689, and miR-2 11 - 3p is hsa - miR - 211 - 3p, miR - 6511b - 5p is hsa - miR - 6511b - 5p, miR - 4750 - 5p is hsa - miR - 475 0 - 5p, miR - 6126 is hsa - miR - 6126, miR - 614 is hsa - miR - 614, miR - 7110 - 5p is hsa - miR - 7110 - 5p, miR - 744 - 5p is hsa - miR - 744 - 5p, miR - 6769a - 5p is hsa - miR - 6769a - 5p, miR - 4792 is hs a - miR - 4792, miR - 5787 is hsa - miR - 5787, m iR - 6798 - 5p is hsa - miR - 6798 - 5p, miR - 6781 - 5 p is hsa - miR - 6781 - 5p, miR - 4419b is hsa - miR - 4 419b, miR - 4446 - 3p is hsa - miR - 4446 - 3p, m iR - 4259 is hsa - miR - 4259, miR - 5572 is hsa - miR - 5572, miR - 6075 is hsa - miR - 6075, miR - 29 6 - 3p is hsa - miR - 296 - 3p, miR - 6891 - 5p is hsa - m iR - 6891 - 5p, miR - 4745 - 5p is hsa - miR - 4745 - 5 p, miR - 6775 - 5p is hsa - miR - 6775 - 5p, miR - 6870 - 5p is hsa - miR - 6870 - 5p, miR - 920 is hsa - m iR - 920, miR - 4530 is hsa - miR - 4530, miR - 6 819 - 5p is hsa - miR - 6819 - 5p, miR - 6825 - 5p is hs a - miR - 6825 - 5p, miR - 7847 - 3p is hsa - miR - 784 It is 7-3p, miR-6131 is hsa-miR-6131, and miR-443 3-3p is hsa-miR-4433-3p, and miR-1228-5p is hsa- miR-1228-5p, and miR-6743-5p is hsa-miR-6743- 5p, miR-1268a is hsa-miR-1268a, and miR-391 7 is hsa-miR-3917, and miR-6786-5p is hsa-miR-67 86-5p, miR-3154 is hsa-miR-3154, and miR-63 8 is hsa-miR-638, and miR-6741-5p is hsa-miR-674 1-5p, miR-6889-5p is hsa-miR-6889-5p, and m iR-6840-3p is hsa-miR-6840-3p, and miR-6510-5 p is hsa-miR-6510-5p, miR-3188 is hsa-miR-31 88, miR-551b-5p is hsa-miR-551b-5p, and miR -5001-5p is hsa-miR-5001-5p, and miR-1268b is hs a-miR-1268b, and miR-7107-5p is hsa-miR-7107- 5p, miR-6824-5p is hsa-miR-6824-5p, and miR -6732-5p is hsa-miR-6732-5p, and miR-371a-5p is hsa-miR-371a-5p, and miR-6794-5p is hsa-miR-6 794-5p, miR-6779-5p is hsa-miR-6779-5p, and miR-4271 is hsa-miR-4271, and miR-5195-3p is hs a-miR-5195-3p, and miR-6762-5p is hsa-miR-676 2-5p, miR-939-5p is hsa-miR-939-5p, and miR -1247-3p is hsa-miR-1247-3p, and miR-6777-5p is hsa-miR-6777-5p, miR-6722-3p is hsa-miR-6 722-3p, miR-3656 is hsa-miR-3656, and miR-4 688 is hsa-miR-4688, and miR-3195 is hsa-miR-319 5, miR-6766-5p is hsa-miR-6766-5p, and miR- 4447 is hsa-miR-4447, miR-4656 is hsa-miR-46 56, miR-7108-5p is hsa-miR-7108-5p, and miR -3191-3p is hsa-miR-3191-3p, and miR-1273g-3p is hsa-miR-1273g-3p, miR-4463 is hsa-miR-44 63, miR-2861 is hsa-miR-2861, and miR-3196 is hsa-miR-3196, miR-6877-5p is hsa-miR-6877 -5p, miR-3679-5p is hsa-miR-3679-5p, and mi R-4442 is hsa-miR-4442, and miR-6789-5p is hsa-m iR-6789-5p, miR-6782-5p is hsa-miR-6782-5 p, miR-486-3p is hsa-miR-486-3p, and miR-60 85 is hsa-miR-6085, and miR-4746-3p is hsa-miR-4 746-3p, miR-619-5p is hsa-miR-619-5p, and m iR-937-5p is hsa-miR-937-5p, and miR-6803-5p is hsa-miR-6803-5p, and miR-4298 is hsa-miR-4298 and miR-4454 is hsa-miR-4454, and miR-4459 is hs a-miR-4459, and miR-7150 is hsa-miR-7150, and m iR-6880-5p is hsa-miR-6880-5p, and miR-4449 is h sa-miR-4449, and miR-8063 is hsa-miR-8063, and miR-4695-5p is hsa-miR-4695-5p, and miR-6132 is hsa-miR-6132, and miR-6829-5p is hsa-miR-6829 -5p, and miR-4486 is hsa-miR-4486, and miR-6805 -3p is hsa-miR-6805-3p, and miR-6826-5p is hsa-m iR-6826-5p, and miR-4508 is hsa-miR-4508, and m iR-1343-5p is hsa-miR-1343-5p, and miR-7114-5 p is hsa-miR-7114-5p, and miR-3622a-5p is hsa-mi R-3622a-5p, and miR-6765-5p is hsa-miR-6765-5 p, and miR-7845-5p is hsa-miR-7845-5p, and miR- 3960 is hsa-miR-3960, and miR-6749-5p is hsa-miR -6749-5p, and miR-1260b is hsa-miR-1260b, and m iR-6799-5p is hsa-miR-6799-5p, and miR-4723-5 p is hsa-miR-4723-5p, miR-6784-5p is hsa-miR -6784-5p, miR-5100 is hsa-miR-5100, miR -6769b-5p is hsa-miR-6769b-5p, miR-1207-5 p is hsa-miR-1207-5p, miR-642a-3p is hsa-miR -642a-3p, miR-4505 is hsa-miR-4505, miR -4270 is hsa-miR-4270, miR-6721-5p is hsa-mi R-6721-5p, miR-7111-5p is hsa-miR-7111-5p and miR-6791-5p is hsa-miR-6791-5p, miR-7 109-5p is hsa-miR-7109-5p, miR-4258 is hsa-m iR-4258, miR-6515-3p is hsa-miR-6515-3p and miR-6851-5p is hsa-miR-6851-5p, miR-612 5 is hsa-miR-6125, miR-4749-5p is hsa-miR-47 49-5p, miR-4726-5p is hsa-miR-4726-5p, and miR-4513 is hsa-miR-4513, miR-6089 is hsa-mi R-6089, miR-6816-5p is hsa-miR-6816-5p and miR-4466 is hsa-miR-4466, miR-4488 is hsa-m iR-4488, miR-6752-5p is hsa-miR-6752-5p and miR-4739 is hsa-miR-4739, the device according to (11).

[0043] ​(13) The nucleic acid is a polynucleotide represented by any one of the following (a) to (e): (a) A polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856, or a base sequence in which u is t in the base sequence, its variant, its derivative, or a fragment thereof containing 15 or more consecutive bases, (b) A polynucleotide containing a base sequence complementary to the base sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856, or a base sequence in which u is t in the base sequence, (c) A polynucleotide consisting of a base sequence complementary to the base sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856, or a base sequence in which u is t in the base sequence, its variant, its derivative, or a fragment thereof containing 15 or more consecutive bases, (d) A polynucleotide containing a base sequence complementary to the base sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856, or a base sequence in which u is t in the base sequence, and (e) A polynucleotide that hybridizes under stringent conditions with any one of the polynucleotides of (a) to (d) above, The device according to (11) or (12) is a polynucleotide selected from the group consisting of .

[0044] (14) The device is miR-760, miR-602, which are another breast cancer marker, miR-423-5p, miR-92a-2-5p, miR-16-5p, miR-4 51a, miR-135a-3p, miR-486-5p, miR-4257, miR- 92b-5p, miR-1915-3p, miR-718, miR-940, miR-2 96-5p, miR-23b-3p, and miR-92a-3p, selected from the group consisting of​​​​​ A nucleic acid that can specifically bind to at least one polynucleotide, further comprising the device according to any one of (11) to (13).

[0045] (15) miR-760 is hsa-miR-760, miR-602 is hsa-m iR-602, miR-423-5p is hsa-miR-423-5p, m iR-92a-2-5p is hsa-miR-92a-2-5p, miR-16-5 p is hsa-miR-16-5p, miR-451a is hsa-miR-451a and miR-135a-3p is hsa-miR-135a-3p, miR-4 86-5p is hsa-miR-486-5p, miR-4257 is hsa-miR -4257, miR-92b-5p is hsa-miR-92b-5p, mi R-1915-3p is hsa-miR-1915-3p, miR-718 is hsa -miR-718, miR-940 is hsa-miR-940, miR-2 96-5p is hsa-miR-296-5p, miR-23b-3p is hsa-m iR-23b-3p, and miR-92a-3p is hsa-miR-92a-3 p, the device according to (14).

[0046] (16) The nucleic acid is a polynucleotide represented by any of the following (f) to (j): (f) A polynucleotide consisting of a base sequence represented by any of SEQ ID NOs: 236 to 251 or a base sequence in which u is t in the base sequence, a variant thereof, a derivative thereof, or a fragment thereof containing 1 5 or more consecutive bases, 5 or more consecutive bases, (g) A polynucleotide containing a base sequence represented by any of SEQ ID NOs: 236 to 251, (h) A polynucleotide consisting of a base sequence represented by any of SEQ ID NOs: 236 to 251 or a base sequence complementary to the base sequence in which u is t in the base sequence, a variant thereof, its derivative, or a fragment thereof containing 15 or more consecutive bases, (i) A polynucleotide containing a base sequence represented by any of SEQ ID NOs: 236 to 251 or a base sequence complementary to the base sequence in which u is t in the base sequence, and (j) A polynucleotide that hybridizes under stringent conditions with any of the polynucleotides of (f) to (i) above, The polynucleotide is selected from the group consisting of polynucleotides described in (14) or (15).

[0047] (17) The device further comprises a nucleic acid that can specifically bind to at least one polynucleotide selected from the group consisting of miR-658, miR-684 2-5p, miR-6124, miR-6765-3p, miR-7106-5p, mi R-4534, miR-92b-3p, miR-3135b, miR-4687-3p, miR-762, miR-3619-3p, miR-4467, miR-557, miR -1237-5p, miR-1908-5p, miR-4286, miR-6885-5 p, and miR-6763-5p, and is the device described in any of (11) to (16).

[0048] (18) miR-658 is hsa-miR-658, miR-6842-5p is h sa-miR-6842-5p, miR-6124 is hsa-miR-6124 and miR-6765-3p is hsa-miR-6765-3p, miR-71 06-5p is hsa-miR-7106-5p, miR-4534 is hsa-mi R-4534, miR-92b-3p is hsa-miR-92b-3p, m iR-3135b is hsa-miR-3135b, miR-4687-3p is hs a-miR-4687-3p, miR-762 is hsa-miR-762, miR-3619-3p is hsa-miR-3619-3p, miR-4467 is hsa-miR-4467, miR-557 is hsa-miR-557, m iR-1237-5p is hsa-miR-1237-5p, miR-1908-5 p is hsa-miR-1908-5p, miR-4286 is hsa-miR-42 86, miR-6885-5p is hsa-miR-6885-5p, and miR-6763-5p is hsa-miR-6763-5p, the device according to (17). vice.

[0049] (19) The nucleic acid is a polynucleotide represented by any of the following (k) to (o): (k) A polynucleotide consisting of a base sequence represented by any of SEQ ID NOs: 252 to 269 or a base sequence in which u is t in the base sequence, a variant thereof, a derivative thereof, or a fragment thereof containing 1 5 or more consecutive bases, 5 or more consecutive bases, (l) A polynucleotide containing a base sequence represented by any of SEQ ID NOs: 252 to 269, (m) A polynucleotide consisting of a base sequence represented by any of SEQ ID NOs: 252 to 269 or a base sequence complementary to the base sequence in which u is t in the base sequence, a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, (n) A base sequence represented by any of SEQ ID NOs: 252 to 269 or a base sequence in which u is t in the base sequence, or a polynucleotide consisting of a base sequence complementary to the base sequence, a variant thereof, A polynucleotide comprising a nucleotide sequence complementary to the nucleotide sequence in which u is t, and (o) a polynucleotide that hybridizes with any one of the polynucleotides of (k) to (n) under stringent conditions A polynucleotide selected from the group consisting of The device according to (17) or (18), which is a polynucleotide selected from the group consisting of .

[0050] (20) The device according to any one of (11) to (19), wherein the device is for measurement by hybridization technology.

[0051] (21) The device according to (20), wherein the hybridization technology is nucleic acid array technology.

[0052] (22) The device according to any one of (11) to (21), wherein the device comprises at least two nucleic acids capable of specifically binding to each of at least two polynucleotides selected from all breast cancer markers described in (11) or (12).

[0053] (23) Measuring the expression level of a target nucleic acid in a specimen of a subject using the kit according to any one of (1) to (10) or the device according to any one of (11) to (22), and using the measured expression level and the control expression level of a healthy subject measured in the same manner to evaluate in vitro whether the subject has breast cancer or does not have breast cancer. A method for detecting breast cancer, comprising

[0054] (24) The method according to (23), wherein the subject is a human.

[0055] (25) The method according to (23) or (24), wherein the specimen is blood, serum or plasma.

[0056] <Definition of Terms> The terms used in this specification have the following definitions. The representations by abbreviations such as nucleotide, polynucleotide, DNA, RNA, etc. shall follow the "Guidelines for the Preparation of Specifications, etc. Containing Base Sequences or Amino Acid Sequences" (edited by the Japan Patent Office) and the common practice in the art.

[0057] As used herein, the term "polynucleotide" is used for nucleic acids including any of RNA, DNA, and RNA / DNA ( chimeric). The above DNA includes cDNA, genomic DNA, and synthetic DNA. The above RNA includes total RNA, mRNA, rRNA, miRNA, siRNA, snoRNA, snRNA, non-coding RNA, and synthetic RNA. As used herein, "synthetic DNA" and "synthetic RNA" are DNAs and RNAs artificially produced, for example, using an automatic nucleic acid synthesizer, based on a predetermined base sequence (which may be either a natural sequence or an unnatural sequence). As used herein, the term "unnatural sequence" is intended to be used in a broad sense and includes sequences different from the natural sequence, such as sequences containing substitutions, deletions, insertions, and / or additions of one or more nucleotides (i.e., mutant sequences), sequences containing one or more modified nucleotides (i.e., modified sequences), etc. Also, in this specification, polynucleotides are used interchangeably with nucleic acids.

[0058] As used herein, the term "fragment" refers to a polynucleotide (including oligonucleotides) having a base sequence of a continuous part of a polynucleotide, which is 15 bases or more, preferably 1 ​ It is desirable to have a length of 7 bases or more, more preferably 19 bases or more.

[0059] As used herein, the term "gene" is intended to include not only RNA and double-stranded DNA, but also single-stranded DNA such as the positive strand (or sense strand) or complementary strand (or antisense strand) that constitutes them. It is not particularly limited by its length. Accordingly, unless otherwise specified, the "gene" as used herein includes double-stranded DNA containing human genomic DNA, single-stranded DNA (positive strand) containing cDNA, single-stranded DNA (complementary strand) having a sequence complementary to the positive strand, microRNA (miRNA), and fragments thereof, transcripts thereof, and any of these. The "gene" includes not only the "gene" represented by a specific nucleotide sequence (or SEQ ID NO.), but also RNA having the same biological function as the RNA encoded by the gene, for example, homologs (i.e., homologs or orthologs), mutants such as gene polymorphisms, and "nucleic acids" encoding derivatives. Specific examples of the "nucleic acid" encoding such a homolog, mutant, or derivative include a nucleotide sequence that hybridizes under the stringent conditions described below to the nucleotide sequence represented by any of SEQ ID NOs: 1 to 871, or a nucleotide sequence in which u is t in the nucleotide sequence, or a complementary sequence thereof. The "gene" is not limited by the distinction of functional regions and can include, for example, an expression control region, a coding region, an exon, or an intron. The "gene" may be contained in a cell, may exist alone extracellularly, or may be encapsulated in a vesicle called an exosome. It is not particularly limited by its length. Therefore, unless otherwise specified, the "gene" as used herein includes double-stranded DNA containing human genomic DNA, single-stranded DNA (positive strand) containing cDNA, single-stranded DNA (complementary strand) having a sequence complementary to the positive strand, microRNA (miRNA), and fragments thereof, transcripts thereof, and any of these. The "gene" includes not only the "gene" represented by a specific nucleotide sequence (or SEQ ID NO.), but also RNA having the same biological function as the RNA encoded by the gene, for example, homologs (i.e., homologs or orthologs), mutants such as gene polymorphisms, and "nucleic acids" encoding derivatives. Specific examples of the "nucleic acid" encoding such a homolog, mutant, or derivative include a nucleotide sequence that hybridizes under the stringent conditions described below to the nucleotide sequence represented by any of SEQ ID NOs: 1 to 871, or a nucleotide sequence in which u is t in the nucleotide sequence, or a complementary sequence thereof. The "gene" is not limited by the distinction of functional regions and can include, for example, an expression control region, a coding region, an exon, or an intron. The "gene" may be contained in a cell, may exist alone extracellularly, or may be encapsulated in a vesicle called an exosome. It is not particularly limited by its length. Therefore, unless otherwise specified, the "gene" as used herein includes double-stranded DNA containing human genomic DNA, single-stranded DNA (positive strand) containing cDNA, single-stranded DNA (complementary strand) having a sequence complementary to the positive strand, microRNA (miRNA), and fragments thereof, transcripts thereof, and any of these. The "gene" includes not only the "gene" represented by a specific nucleotide sequence (or SEQ ID NO.), but also RNA having the same biological function as the RNA encoded by the gene, for example, homologs (i.e., homologs or orthologs), mutants such as gene polymorphisms, and "nucleic acids" encoding derivatives. Specific examples of the "nucleic acid" encoding such a homolog, mutant, or derivative include a nucleotide sequence that hybridizes under the stringent conditions described below to the nucleotide sequence represented by any of SEQ ID NOs: 1 to 871, or a nucleotide sequence in which u is t in the nucleotide sequence, or a complementary sequence thereof. The "gene" is not limited by the distinction of functional regions and can include, for example, an expression control region, a coding region, an exon, or an intron. The "gene" may be contained in a cell, may exist alone extracellularly, or may be encapsulated in a vesicle called an exosome. It is not particularly limited by its length. Therefore, unless otherwise specified, the "gene" as used herein includes double-stranded DNA containing human genomic DNA, single-stranded DNA (positive strand) containing cDNA, single-stranded DNA (complementary strand) having a sequence complementary to the positive strand, microRNA (miRNA), and fragments thereof, transcripts thereof, and any of these. The "gene" includes not only the "gene" represented by a specific nucleotide sequence (or SEQ ID NO.), but also RNA having the same biological function as the RNA encoded by the gene, for example, homologs (i.e., homologs or orthologs), mutants such as gene polymorphisms, and "nucleic acids" encoding derivatives. Specific examples of the "nucleic acid" encoding such a homolog, mutant, or derivative include a nucleotide sequence that hybridizes under the stringent conditions described below to the nucleotide sequence represented by any of SEQ ID NOs: 1 to 871, or a nucleotide sequence in which u is t in the nucleotide sequence, or a complementary sequence thereof. The "gene" is not limited by the distinction of functional regions and can include, for example, an expression control region, a coding region, an exon, or an intron. The "gene" may be contained in a cell, may exist alone extracellularly, or may be encapsulated in a vesicle called an exosome. It is not particularly limited by its length. Therefore, unless otherwise specified, the "gene" as used herein includes double-stranded DNA containing human genomic DNA, single-stranded DNA (positive strand) containing cDNA, single-stranded DNA (complementary strand) having a sequence complementary to the positive strand, microRNA (miRNA), and fragments thereof, transcripts thereof, and any of these. The "gene" includes not only the "gene" represented by a specific nucleotide sequence (or SEQ ID NO.), but also RNA having the same biological function as the RNA encoded by the gene, for example, homologs (i.e., homologs or orthologs), mutants such as gene polymorphisms, and "nucleic acids" encoding derivatives. Specific examples of the "nucleic acid" encoding such a homolog, mutant, or derivative include a nucleotide sequence that hybridizes under the stringent conditions described below to the nucleotide sequence represented by any of SEQ ID NOs: 1 to 871, or a nucleotide sequence in which u is t in the nucleotide sequence, or a complementary sequence thereof. The "gene" is not limited by the distinction of functional regions and can include, for example, an expression control region, a coding region, an exon, or an intron. The "gene" may be contained in a cell, may exist alone extracellularly, or may be encapsulated in a vesicle called an exosome. It is not particularly limited by its length. Therefore, unless otherwise specified, the "gene" as used herein includes double-stranded DNA containing human genomic DNA, single-stranded DNA (positive strand) containing cDNA, single-stranded DNA (complementary strand) having a sequence complementary to the positive strand, microRNA (miRNA), and fragments thereof, transcripts thereof, and any of these. The "gene" includes not only the "gene" represented by a specific nucleotide sequence (or SEQ ID NO.), but also RNA having the same biological function as the RNA encoded by the gene, for example, homologs (i.e., homologs or orthologs), mutants such as gene polymorphisms, and "nucleic acids" encoding derivatives. Specific examples of the "nucleic acid" encoding such a homolog, mutant, or derivative include a nucleotide sequence that hybridizes under the stringent conditions described below to the nucleotide sequence represented by any of SEQ ID NOs: 1 to 871, or a nucleotide sequence in which u is t in the nucleotide sequence, or a complementary sequence thereof. The "gene" is not limited by the distinction of functional regions and can include, for example, an expression control region, a coding region, an exon, or an intron. The "gene" may be contained in a cell, may exist alone extracellularly, or may be encapsulated in a vesicle called an exosome. It is not particularly limited by its length. Therefore, unless otherwise specified, the "gene" as used herein includes double-stranded DNA containing human genomic DNA, single-stranded DNA (positive strand) containing cDNA, single-stranded DNA (complementary strand) having a sequence complementary to the positive strand, microRNA (miRNA), and fragments thereof, transcripts thereof, and any of these. The "gene" includes not only the "gene" represented by a specific nucleotide sequence (or SEQ ID NO.), but also RNA having the same biological function as the RNA encoded by the gene, for example, homologs (i.e., homologs or orthologs), mutants such as gene polymorphisms, and "nucleic acids" encoding derivatives. Specific examples of the "nucleic acid" encoding such a homolog, mutant, or derivative include a nucleotide sequence that hybridizes under the stringent conditions described below to the nucleotide sequence represented by any of SEQ ID NOs: 1 to 871, or a nucleotide sequence in which u is t in the nucleotide sequence, or a complementary sequence thereof. The "gene" is not limited by the distinction of functional regions and can include, for example, an expression control region, a coding region, an exon, or an intron. The "gene" may be contained in a cell, may exist alone extracellularly, or may be encapsulated in a vesicle called an exosome. It is not particularly limited by its length. Therefore, unless otherwise specified, the "gene" as used herein includes double-stranded DNA containing human genomic DNA, single-stranded DNA (positive strand) containing cDNA, single-stranded DNA (complementary strand) having a sequence complementary to the positive strand, microRNA (miRNA), and fragments thereof, transcripts thereof, and any of these. The "gene" includes not only the "gene" represented by a specific nucleotide sequence (or SEQ ID NO.), but also RNA having the same biological function as the RNA encoded by the gene, for example, homologs (i.e., homologs or orthologs), mutants such as gene polymorphisms, and "nucleic acids" encoding derivatives. Specific examples of the "nucleic acid" encoding such a homolog, mutant, or derivative include a nucleotide sequence that hybridizes under the stringent conditions described below to the nucleotide sequence represented by any of SEQ ID NOs: 1 to 871, or a nucleotide sequence in which u is t in the nucleotide sequence, or a complementary sequence thereof. The "gene" is not limited by the distinction of functional regions and can include, for example, an expression control region, a coding region, an exon, or an intron. The "gene" may be contained in a cell, may exist alone extracellularly, or may be encapsulated in a vesicle called an exosome. It is not particularly limited by its length.

[0060] In this specification, "exosome" (also known as "exosome") refers to a vesicle enclosed by a lipid bilayer membrane secreted from cells. Exosomes are derived from multivesicular endosomes and may contain biological substances such as "genes" like RNA and DNA, and proteins when released into the extracellular environment. Exosomes are known to be contained in body fluids such as blood, serum, plasma, serum, and lymph.

[0061] In this specification, "transcript" refers to RNA synthesized using the DNA sequence of a gene as a template. RNA polymerase binds to a site called a promoter upstream of the gene, and RNA is synthesized in a form where ribonucleotides are bound to the 3' end to be complementary to the base sequence of DNA. This RNA contains not only the gene itself, but also all sequences from the transcription start point including expression control regions, coding regions, exons or introns to the end of the polyA sequence.

[0062] Also, in this specification, "microRNA (miRNA)" is, unless otherwise specified, transcribed as an RNA precursor with a hairpin-like structure, cleaved by a dsRNA cleaving enzyme having RNase III cleavage activity, incorporated into a protein complex called RISC, and used to intend a non-coding RNA of 15 to 25 bases involved in translational repression of mRNA. Also, "miRNA" used in this specification is not only the "miRNA" represented by a specific base sequence (or SEQ ID NO), but also the precursor of the "miRNA" (pre-miRNA, pri-miRNA), miRNAs having biological functions equivalent to these, such as homologs (i.e., homologs or orthologs), variants such as gene polymorphisms, and derivatives. ​ It exists. Specific examples of such precursors, homologs, variants or derivatives include miRBase release 20 (http: / / www.mirbase.org / ) for identification and, under the stringent conditions described later, have a base sequence that hybridizes with the complementary sequence of any of the specific base sequences represented by any of SEQ ID NOS: 1 to 871 The "miRNA" can be mentioned. Furthermore, the "miRNA" used in the present specification may be a gene product of an miR gene, and such a gene product is a mature miR NA (for example, 15 to 25 bases or 19 to 25 bases of non-coding RNA involved in translational repression of mRNA as described above) or an miRNA precursor (for example, pr e-miRNA or pri-miRNA as described above).

[0063] In the present specification, the "probe" refers to a polynucleotide used for specifically detecting an RNA generated by gene expression or a polynucleotide derived therefrom and / or a polynucleotide complementary thereto.

[0064] In the present specification, the "primer" refers to a polynucleotide that specifically recognizes and amplifies an RNA generated by gene expression or a polynucleotide derived therefrom and / or a polynucleotide complementary thereto. Here, the "complementary polynucleotide (complementary strand, reverse strand)" refers to the full-length sequence of a polynucleotide consisting of a base sequence defined by any of SEQ ID NOS: 1 to 871 or a base sequence in which u is t in the said base sequence, or a partial sequence thereof (here, for convenience, this is referred to as the sense strand), and A:T(U), G:C with respect to it ​​​​Means a polynucleotide that is in a base complementary relationship based on the base pair relationship described above. . However, such a complementary strand is not limited to the case where it forms a completely complementary sequence with the base sequence of the target sense strand, but may also have a complementary relationship such that it can hybridize with the target sense strand under stringent conditions.

[0065] As used herein, "stringent conditions" refers to conditions under which a nucleic acid probe hybridizes to its target sequence to a greater extent (e.g., a measurement value of the average of the background measurement value + 2 times the standard error of the background measurement value or more) than to other sequences. Stringent conditions are sequence-dependent and vary depending on the environment in which hybridization is performed. By controlling the stringency of hybridization and / or washing conditions, a target sequence that is 100% complementary to the nucleic acid probe can be identified. Specific examples of "stringent conditions" are described below.

[0066] As used herein, "Tm value" means the temperature at which the double-stranded portion of a polynucleotide denatures into single strands and the double strands and single strands are present in a 1:1 ratio.

[0067] As used herein, "variant" in the case of nucleic acids refers to a natural variant resulting from polymorphism, mutation, etc., or the base sequence of any one of SEQ ID NOs: 1 to 871, or a base sequence in which u is t in said base sequence, or a variant containing a deletion, substitution, addition, or insertion of one or more bases in a partial sequence thereof, or a variant showing about 90% or more, about 95% or more, about 97% or more, about 98% or more, about 99% or more sequence identity with each of said base sequences or a partial sequence thereof. or a polynucleotide or oligonucleotide containing said base sequence or a partial sequence thereof. The term "hybridizable nucleic acid" refers to a nucleic acid that hybridizes to the nucleic acid under stringent conditions as defined above.

[0068] As used herein, "multiple" refers to an integer of about 10, 9, 8, 7, 6, 5, 4, 3, or 2. It means a number.

[0069] In the present specification, the term "mutant" refers to a mutant that has been produced by site-directed mutagenesis or PCR. These can be produced using well-known techniques such as natural mutagenesis.

[0070] As used herein, "% identity" refers to the percentage of identity between proteins or using a gene search system, with or without introducing gaps, (Zheng Zhang et al., 2000, J. Comput. B iol., vol. 7, p. 203-214; Altschul, SF et al., 1990, Jo Journal of Molecular Biology, Vol. 215, p403-41 0; Pearson, WR et al., 1988, Proc. Natl. Acad. Sci. .USA, Vol. 85, p2444-2448).

[0071] As used herein, a "derivative" refers to a modified nucleic acid, including, but not limited to, a modified nucleic acid, such as a nucleic acid that is fused to a fluorophore. Labeled derivatives, modified nucleotides (e.g. halogen, alkyl such as methyl, methoxy Reconstruction of nucleotides and bases containing alkoxy, thio, carboxymethyl, etc. groups Nucleotides that have undergone synthesis, double bond saturation, deamination, and substitution of oxygen molecules with sulfur molecules. Derivatives including PNA (peptide nucleic acid; Niel Sen, P. E. et al., 1991, Science, Vol. 254, p1497-500), LNA (locked nucleic acid; Obika, S. et al., 1998, Tetrahedron Lett., Vol. 39, p5401-5404), etc. means including the like.

[0072] In this specification, the "nucleic acid" that can specifically bind to a polynucleotide selected from the miRNA that is the above-mentioned breast cancer marker is a synthesized or prepared nucleic acid, specifically including a "nucleic acid probe" or a "primer", and is used directly or indirectly for detecting the presence or absence of breast cancer in a subject, or for diagnosing the presence or absence of breast cancer, the degree of disease, the presence or absence and degree of improvement of breast cancer, the sensitivity to treatment of breast cancer, or for screening candidate substances useful for the prevention, improvement or treatment of breast cancer. These include nucleotides, oligonucleotides and polynucleotides that can specifically recognize and bind to the transcript represented by any of SEQ ID NOs: 1 to 871 or its cDNA synthetic nucleic acid in a sample such as a biological sample, particularly body fluids such as blood and urine, in relation to the development of breast cancer. These nucleotides, oligonucleotides and polynucleotides can be effectively used as a probe for detecting the above-mentioned gene expressed in vivo, such as in tissues and cells, and as a primer for amplifying the above-mentioned gene expressed in vivo. In this specification, the term "detection" can be replaced with terms such as inspection, measurement, detection or assistance in determination. Also, in this specification, the term "evaluation" is used in the sense of including assisting in diagnosis or evaluation based on inspection results or measurement results. for detecting the presence or absence of breast cancer in a subject, or for diagnosing the presence or absence of breast cancer, the degree of disease, the presence or absence and degree of improvement of breast cancer, the sensitivity to treatment of breast cancer, or for screening candidate substances useful for the prevention, improvement or treatment of breast cancer. These include nucleotides, oligonucleotides and polynucleotides that can specifically recognize and bind to the transcript represented by any of SEQ ID NOs: 1 to 871 or its cDNA synthetic nucleic acid in a sample such as a biological sample, particularly body fluids such as blood and urine, in relation to the development of breast cancer. These nucleotides, oligonucleotides and polynucleotides can be effectively used as a probe for detecting the above-mentioned gene expressed in vivo, such as in tissues and cells, and as a primer for amplifying the above-mentioned gene expressed in vivo. In this specification, the term "detection" can be replaced with terms such as inspection, measurement, detection or assistance in determination. Also, in this specification, the term "evaluation" is used in the sense of including assisting in diagnosis or evaluation based on inspection results or measurement results. These nucleotides, oligonucleotides and polynucleotides can be effectively used as a probe for detecting the above-mentioned gene expressed in vivo, such as in tissues and cells, and as a primer for amplifying the above-mentioned gene expressed in vivo. These nucleotides, oligonucleotides and polynucleotides can be effectively used as a probe for detecting the above-mentioned gene expressed in vivo, such as in tissues and cells, and as a primer for amplifying the above-mentioned gene expressed in vivo. These nucleotides, oligonucleotides and polynucleotides can be effectively used as a probe for detecting the above-mentioned gene expressed in vivo, such as in tissues and cells, and as a primer for amplifying the above-mentioned gene expressed in vivo. These nucleotides, oligonucleotides and polynucleotides can be effectively used as a probe for detecting the above-mentioned gene expressed in vivo, such as in tissues and cells, and as a primer for amplifying the above-mentioned gene expressed in vivo.

[0073] In this specification, the term "detection" can be replaced with terms such as inspection, measurement, detection or assistance in determination. Also, in this specification, the term "evaluation" is used in the sense of including assisting in diagnosis or evaluation based on inspection results or measurement results. In this specification, the term "evaluation" is used in the sense of including assisting in diagnosis or evaluation based on inspection results or measurement results.

[0074] As used herein, the "subject" means mammals such as humans, primates including chimpanzees, dogs, cats, any pet animals, livestock animals such as cows, horses, sheep, goats, and rodents such as mice and rats. Also, "healthy subject" also means such a mammal that is not suffering from the cancer to be detected.

[0075] As used herein, "P" or "P-value" refers to the probability that a statistic more extreme than the statistic actually calculated from the data is observed under the null hypothesis in a statistical test. Thus, the smaller the "P" or "P-value", the more likely there is a significant difference between the comparison subjects.

[0076] In this specification, "sensitivity" means the value of (number of true positives) / (number of true positives + number of false negatives). If the sensitivity is high, it becomes possible to detect breast cancer at an early stage, leading to complete excision of the cancerous part and a reduction in the recurrence rate.

[0077] In this specification, "specificity" means (number of true negatives) / (number of true negatives + number of false positives). If the specificity is high, it prevents the unnecessary additional examinations due to misclassifying healthy subjects as breast cancer patients, leading to a reduction in the burden on patients and medical costs.

[0078] In this specification, "accuracy" means the value of (number of true positives + number of true negatives) / (total number of cases). Accuracy indicates the proportion of correct discrimination results for all specimens and is the first index for evaluating the detection performance.

[0079] As used herein, the "specimen" to be determined, detected, or diagnosed means the occurrence of breast cancer, the development of breast cancer ​​​​​​​​​​​The gene of the present invention exhibits changes in expression along with the progression of cancer and the exertion of therapeutic effects against breast cancer. Refers to tissues and biological materials. Specifically, breast tissue and its surrounding blood vessels, lymph nodes, and organs, as well as organs suspected of metastasis, skin, and body fluids such as blood, urine, saliva, sweat, and tissue exudates, sera, plasma prepared from blood, and others, feces, hair, etc. Furthermore, biological samples extracted from these, specifically genes such as RNA and miRNA.

[0080] As used herein, the term "hsa-miR-4783-3p gene" or "hsa-miR-4783-3p" refers to the hsa-miR-4783-3p gene (miRBase Accession No. MIMAT0019947) described in SEQ ID NO: 1, and also includes homologs or orthologs of other species. The hsa-miR-4783-3p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71, p 78-86. Also, "hsa-miR-4783-3p" has a hairpin-like structure as its precursor, "hsa-mir-4783" (miRBase Accession No. MI0017428, SEQ ID NO: 270) is known.

[0081] As used herein, the term "hsa-miR-4730 gene" or "hsa-miR-4730" refers to the hsa-miR-4730 gene (miRBase Accession No. MIMAT0019852) described in SEQ ID NO: 2 and homologs or orthologs of other species. The hsa-miR-4730 gene is described in Persson H et al., 2011, Cancer Res, 71, p78-86 ​ It can be obtained by a method. Also, "hsa-miR-4730" has, as its precursor, "hsa-mir-4730" (miRBase Access ion No.MI0017367, SEQ ID NO: 271) which takes a hairpin-like structure.

[0082] As used herein, the term "hsa-miR-1307-3p gene" or "hsa-mi R-1307-3p" includes the hsa-miR-1307-3 p gene (miRBase Accession No.MIMAT0005951) described in SEQ ID NO: 3, as well as other species homologs or orthologs, etc. The hsa-miR-1307- 3p gene can be obtained by the method described in Morin RD et al., 2008, Genome Res, 18, p6 10-621. Also, "hsa-miR-1 307-3p" has, as its precursor, "hsa-mir-1307" which takes a hairpin-like structure (miRBase Accession No.MI0006444, SEQ ID NO: 272 ).

[0083] As used herein, the term "hsa-miR-4634 gene" or "hsa-miR-4 634" includes the hsa-miR-4634 gene (miRB ase Accession No.MIMAT0019691) described in SEQ ID NO: 4 and other species homolog s or orthologs, etc. The hsa-miR-4634 gene can be obtained by the method described in Perss on H et al., 2011, Cancer Res, 71, p78-86. Also, "hsa-miR-4634" has, as its precursor, "hsa-mir-4634" which has a hairpin-like structure (miRBase Access ion No.MI0017261, SEQ ID NO: 273) is known.

[0084] As used herein, the term "hsa-miR-663a gene" or "hsa-miR-6 63a" refers to the hsa-miR-663a gene described in SEQ ID NO: 5 (miRB ase Accession No.MIMAT0003326) and other homologs or orthologs of other species. The hsa-miR-663a gene can be obtained by the method described in Cummi ns JM et al., 2006, Proc Natl Acad Sci U S A, 10 3, p3687-3692. Also, "hs a-miR-663a" has, as its precursor, "hsa-mir- 663a" which has a hairpin-like structure (miRBase Accession No.MI0003672, SEQ ID NO number 274) is known.

[0085] As used herein, the term "hsa-miR-4532 gene" or "hsa-miR-4 532" refers to the hsa-miR-4532 gene described in SEQ ID NO: 6 (miRB ase Accession No.MIMAT0019071) and other homologs or orthologs of other species. The hsa-miR-4532 gene can be obtained by the method described in Jima DD et al., 2010, Blood, 116, e118-e127. Also, "hsa-miR-4532" has, as its precursor, a hair pin-like structure "hsa-mir-4532" (miRBase Accession No.MI0016899, SEQ ID NO: 275) is known. ​​​

[0086] As used herein, the term "hsa-miR-7704 gene" or "hsa-miR-7 704" includes the hsa-miR-7704 gene (miRBase Accession No. MIMAT0030019) described in SEQ ID NO: 7, as well as homologs or orthologs of other species. The hsa-miR-7704 gene can be obtained by the method described in Swaminathan S et al., 2013, Biochem Biophys Res Commun, 434, p228-234. Also, "hsa-miR-7704" is known to have a hairpin-like structure as its precursor, "hsa-m ir-7704" (miRBase Accession No. MI0025240, SEQ ID NO: 276). As used herein, the term "hsa-miR-3178 gene" or "hsa-miR-3 178" includes the hsa-miR-3178 gene (miRBase Accession No. MIMAT0015055) described in SEQ ID NO: 8, as well as homologs or orthologs of other species. The hsa-miR-3178 gene can be obtained by the method described in Stark MS et al., 2010, PLoS One, 5, e9685. Also, "hsa-miR-3178" is known to have a hairpin -like structure as its precursor, "hsa-mir-3178" (miRBase Accession N o. MI0014212, SEQ ID NO: 277).

[0087] As used herein, the term "hsa-miR-6729-5p gene" or "hsa-mi 6729-5p" includes the hsa-miR-6729-5p gene (miRBase Accession No. MIMAT0030020) described in SEQ ID NO: 9, as well as homologs or orthologs of other species. The hsa-miR-6729-5p gene can be obtained by the method described in Swaminathan S et al., 2013, Biochem Biophys Res Commun, 434, p228-234. Also, "hsa-miR-6729-5p" is known to have a hairpin-like structure as its precursor, "hsa-m ir-6729-5p" (miRBase Accession No. MI0025241, SEQ ID NO: 278). Also, "hsa-miR-6729-5p" is known to have a hairpin -like structure as its precursor, "hsa-mir-6729-5p" (miRBase Accession N o. MI0025241, SEQ ID NO: 278).

[0088] As used herein, the term "hsa-miR-6729-5p gene" or "hsa-mi The term "R-6729-5p" refers to hsa-miR-6729-5 described in SEQ ID NO: 9 p gene (miRBase Accession No. MIMAT0027359), and also includes other species homologs or orthologs, etc. The hsa-miR-6729- 5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p 1634-1645. Also, "hsa-mi R-6729-5p" has a hairpin-like structure as its precursor, "hsa-mir-6 729" (miRBase Accession No. MI0022574, SEQ ID NO: 278) is known.

[0089] As used herein, the term "hsa-miR-6090 gene" or "hsa-miR-6 090" refers to the hsa-miR-6090 gene described in SEQ ID NO: 10 (miR Base Accession No. MIMAT0023715) and other species homologs or orthologs, etc. The hsa-miR-6090 gene can be obtained by the method described in Yoo JK et al., 2012, Stem Cells Dev, 21, p2049-2057. Also, "hsa-miR-6090" has a hairpin-like structure as its precursor, "hsa-mir-6090" (miRBase Accession No. MI0020367, SEQ ID NO: 279) is known.

[0090] As used herein, the term "hsa-miR-4732-5p gene" or "hsa-mi R-4732-5p" refers to hsa-miR-4732- described in SEQ ID NO: 11 5p gene (miRBase Accession No. MIMAT0019855) and also includes other species homologs or orthologs, etc. hsa-miR-4732 -5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71, pp. 78 - 86. Also, "hsa-miR-4 732-5p" has a hairpin-like structure as its precursor, "hsa-mir-4732 " (miRBase Accession No. MI0017369, SEQ ID NO: 280 ).

[0091] As used herein, the term "hsa-miR-3184-5p gene" or "hsa-mi R-3184-5p" refers to the hsa-miR-3184- 5p gene (miRBase Accession No. MIMAT0015064) described in SEQ ID NO: 12 and also includes other species homologs or orthologs, etc. hsa-miR-3184 -5p gene can be obtained by the method described in Stark MS et al., 2010, PLoS One, 5, e9685. Also, "hsa-miR-3184-5 p" has a hairpin-like structure as its precursor, "hsa-mir-3184" (miR Base Accession No. MI0014226, SEQ ID NO: 281) is known .

[0092] As used herein, the term "hsa-miR-6727-5p gene" or "hsa-mi R-6727-5p" refers to the hsa-miR-6727- 5p gene (miRBase Accession No. MIMAT0027355) described in SEQ ID NO: 13 It includes other species homologs or orthologs, etc. hsa-miR-6727 The -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, pp. 1634-1645. Also, "hsa-m iR-6727-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6727" (miRBase Accession No. MI0022572, SEQ ID No. 282) is known.

[0093] As used herein, the term "hsa-miR-6088 gene" or "hsa-miR-6 088" refers to the hsa-miR-6088 gene described in SEQ ID NO: 14 (miR Base Accession No. MIMAT0023713) and other species homologs or orthologs, etc. The hsa-miR-6088 gene can be obtained by the method described in Yoo JK et al., 2012, Stem Cells Dev, 21, pp. 2049-2057. Also, "hsa-miR-6088" has a hairpin-like structure as its precursor, "hsa-mir-6088" (miRBase Accession No. MI0020365, SEQ ID NO: 283) is known.

[0094] As used herein, the term "hsa-miR-4674 gene" or "hsa-miR-4 674" refers to the hsa-miR-4674 gene described in SEQ ID NO: 15 (miR Base Accession No. MIMAT0019756) and other species homologs or orthologs, etc. The hsa-miR-4674 gene is from Pers ​Son H et al., 2011, Cancer Res, Vol. 71, p78 - 86 can be obtained by the method described in In addition, "hsa - miR - 4674" has a hairpin - like structure as its precursor, "hsa - mir - 4674" (miRBase Acces sion No. MI0017305, SEQ ID NO: 284) is known.

[0095] As used herein, the term "hsa - miR - 8073 gene" or "hsa - miR - 8 073" includes the hsa - miR - 8073 gene described in SEQ ID NO: 16 (miR Base Accession No. MIMAT0031000) and other homologs or orthologs of other species. The hsa - miR - 8073 gene can be obtained by the method described in Wang HJ et al., 2013, Shock, Vol. 39, p480 - 487. In addition, "hsa - miR - 8073" has a hairpin - like structure as its precursor, "hsa - mir - 8073" (miRBase Accession No. MI0025909, SEQ ID NO: 285) is known. As used herein, the term "hsa - miR - 4787 - 5p gene" or "hsa - miR R - 4787 - 5p" includes the hsa - miR - 4787 - 5p gene described in SEQ ID NO: 17 (miRBase Accession No. MIMAT0019956)

[0096] and other homologs or orthologs of other species. The hsa - miR - 4787 - 5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, Vol. 71, p78 - 86. In addition, "hsa - miR - 4 As used herein, the term "hsa - miR - 4787 - 5p gene" or "hsa - miR - 4787 - 5p" includes the hsa - miR - 4787 - 5p gene described in SEQ ID NO: 17 (miRBase Accession No. MIMAT0019956) and other homologs or orthologs of other species. The hsa - miR - 4787 - 5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, Vol. 71, p78 - 86. In addition, "hsa - miR - 4 - 5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, Vol. 71, p78 - 86. Also, "hsa - miR - 4 "787-5p" has a hairpin-like structure as its precursor, "hsa-mir-4787" "(miRBase Accession No. MI0017434, SEQ ID NO: 286 ) is known."

[0097] As used herein, the term "hsa-miR-1469 gene" or "hsa-miR-1 469" refers to the hsa-miR-1469 gene described in SEQ ID NO: 18 (miR Base Accession No. MIMAT0007347) and other homologs or orthologs of other species. The hsa-miR-1469 gene can be obtained by the method described by Kawa ji H et al., 2008, BMC Genomics, Vol. 9, p157 . Also, "hsa-miR-1469" has, as its precursor, a hairpin-like structure, "hsa-mir-1469" (miRBase Accessi on No. MI0007074, SEQ ID NO: 287) is known."

[0098] As used herein, the term "hsa-miR-125a-3p gene" or "hsa-mi R-125a-3p" refers to the hsa-miR-125a- 3p gene described in SEQ ID NO: 19 (miRBase Accession No. MIMAT0004602) and other homologs or orthologs of other species. The hsa-miR-125a -3p gene can be obtained by the method described by Lagos-Quintana M et al., 2002, Curr Bio l, Vol. 12, pp735-739. Also, "h sa-miR-125a-3p" has, as its precursor, a hairpin-like structure, "hsa- ​"mir-125a" (miRBase Accession No. MI0000469 , SEQ ID NO: 288) is known.

[0099] As used herein, the term "hsa-miR-1233-5p gene" or "hsa-mi R-1233-5p" refers to the hsa-miR-1233- 5p gene (miRBase Accession No. MIMAT0022943) described in SEQ ID NO: 20 and also includes other species homologs or orthologs, etc. The hsa-miR-1233 -5p gene can be obtained by the method described in Berezikov E et al., 2007, Mol Cell, Vol. 28, pp328-336. Also, "hsa-miR -1233-5p" has a hairpin-like structure as its precursor, "hsa-mir-12 33-1, hsa-mir-1233-2" (miRBase Accession N o. MI0006323, MI0015973, SEQ ID NOs: 289, 290) is known.

[0100] As used herein, the term "hsa-miR-885-3p gene" or "hsa-miR -885-3p" refers to the hsa-miR-885-3p gene described in SEQ ID NO: 21 (miRBase Accession No. MIMAT0004948) and its other species homologs or orthologs, etc. The hsa-miR-885-3p gene can be obtained by the method described in Berezikov E et al., 2006, Genome Res, Vol. 16, p1 289-1298. Also, "hsa-miR -885-3p" has a hairpin-like structure as its precursor, "hsa-mir-885 ​」(miRBase Accession No. MI0005560, SEQ ID NO: 291 ) is known.

[0101] As used herein, the term "hsa-miR-6802-5p gene" or "hsa-mi R-6802-5p" refers to the hsa-miR-6802- 5p gene (miRBase Accession No. MIMAT0027504) described in SEQ ID NO: 22 and includes other species homologs or orthologs, etc. The hsa-miR-6802 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-m iR-6802-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6802" (miRBase Accession No. MI0022647, SEQ ID NO: 292) is known.

[0102] As used herein, the term "hsa-miR-328-5p gene" or "hsa-miR -328-5p" refers to the hsa-miR-328-5p gene described in SEQ ID NO: 23 (miRBase Accession No. MIMAT0026486) and its other species homologs or orthologs, etc. The hsa-miR-328-5p gene can be obtained by the method described in Kim J et al., 2004, Proc Natl Acad Sci US A, 101, p360-365. Also, " hsa-miR-328-5p" has a hairpin-like structure as its precursor, "hsa- mir-328" (miRBase Accession No. MI0000804, The sequence number 293) is known.

[0103] As used herein, the term "hsa-miR-6787-5p gene" or "hsa-mi R-6787-5p" refers to the hsa-miR-6787- 5p gene (miRBase Accession No. MIMAT0027474) described in SEQ ID NO: 24 and also includes other species homologs or orthologs, etc. The hsa-miR-6787 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634 - 1645. Also, "hsa-m iR-6787-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6787" (miRBase Accession No. MI0022632, SEQ ID NO: 294) is known.

[0104] As used herein, the term "hsa-miR-8069 gene" or "hsa-miR-8 069" refers to the hsa-miR-8069 gene (miR Base Accession No. MIMAT0030996) described in SEQ ID NO: 25 and also includes other species homo logs or orthologs, etc. The hsa-miR-8069 gene can be obtained by the method described in Wang HJ et al., 2013, Shock, 39, p480 - 487. Also, "hsa-miR-8069" has a hairpin -like structure as its precursor, "hsa-mir-8069" (miRBase Accession No. MI0025905, SEQ ID NO: 295) is known.

[0105] ​As used herein, the term "hsa-miR-6875-5p gene" or "hsa-mi R-6875-5p" includes the hsa-miR-6875- 5p gene (miRBase Accession No. MIMAT0027650) described in SEQ ID NO: 26 and other homologs or orthologs of other species. The hsa-miR-6875 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-m iR-6875-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6875" (miRBase Accession No. MI0022722, SEQ ID NO 296) is known.

[0106] As used herein, the term "hsa-miR-1246 gene" or "hsa-miR-1 246" includes the hsa-miR-1246 gene (miR Base Accession No. MIMAT0005898) described in SEQ ID NO: 27 and other homologs or orthologs of other species. The hsa-miR-1246 gene can be obtained by the method described in Mori n RD et al., 2008, Genome Res, 18, p610-621 . Also, "hsa-miR-1246" has a hairpin-like structure as its precursor "hsa-mir-1246" (miRBase Acce ssion No. MI0006381, SEQ ID NO: 297) is known.

[0107] As used herein, the term "hsa-miR-4734 gene" or "hsa-miR-4 The term "734" refers to the hsa-miR-4734 gene described in SEQ ID NO: 28 (miR Base Accession No. MIMAT0019859) and homologs or orthologs of other species. The hsa-miR-4734 gene can be obtained by the method described by Pers son H et al., 2011, Cancer Res, Vol. 71, p78-86. Also, "hsa-miR-4734" has a precursor that forms a hairpin-like structure, namely "hsa-mir-4734" (miRBase Acces sion No. MI0017371, SEQ ID NO: 298). The term "hsa-miR-6757-5p gene" or "hsa-mi R-6757-5p" as used herein refers to the hsa-miR-6757-

[0108] 5p gene described in SEQ ID NO: 29 (miRBase Accession No. MIMAT0027414) and homologs or orthologs of other species. The hsa-miR-6757 -5p gene can be obtained by the method described by Ladewig E et al., 2012, Genome Res, Vol. 22, p1634-1645. Also, "hsa-m iR-6757-5p" has a precursor that forms a hairpin-like structure, namely "hsa-mir- 6757" (miRBase Accession No. MI0022602, SEQ ID NO umber 299). The term "hsa-miR-6756-5p gene" or "hsa-mi R-6756-5p" as used herein refers to the hsa-miR-6756-

[0109] 5p gene described in SEQ ID NO: 30 and homologs or orthologs of other species 5p gene (miRBase Accession No. MIMAT0027412) and other homologs or orthologs of other species are included. hsa-miR-6756 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-m iR-6756-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6756" (miRBase Accession No. MI0022601, SEQ ID No. 300) is known.

[0110] As used herein, the term "hsa-miR-3665 gene" or "hsa-miR-3 665" refers to the hsa-miR-3665 gene described in SEQ ID NO: 31 (miR Base Accession No. MIMAT0018087) and other homologs or orthologs of other species. The hsa-miR-3665 gene can be obtained by the method described in Xie X et al., 2005, Nature, 434, p338-345. Also, "hsa-miR-3665" has a hairpin -like structure as its precursor, "hsa-mir-3665" (miRBase Accession No. MI0016066, SEQ ID NO: 301) is known. No.MI0016066, SEQ ID NO: 301) is known.

[0111] As used herein, the term "hsa-miR-6836-3p gene" or "hsa-mi R-6836-3p" refers to the hsa-miR-6836- 3p gene described in SEQ ID NO: 32 (miRBase Accession No. MIMAT0027575) It includes other species homologs or orthologs, etc. hsa-miR-6836 The -3p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, pp. 1634-1645. Also, "hsa-m iR-6836-3p" has a hairpin-like structure as its precursor, "hsa-mir- 6836" (miRBase Accession No. MI0022682, SEQ ID No. 302) is known.

[0112] As used herein, the term "hsa-miR-6821-5p gene" or "hsa-mi R-6821-5p" refers to the hsa-miR-6821- 5p gene (miRBase Accession No. MIMAT0027542) described in SEQ ID NO: 33 and includes other species homologs or orthologs, etc. hsa-miR-6821 The -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, pp. 1634-1645. Also, "hsa-m iR-6821-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6821" (miRBase Accession No. MI0022666, SEQ ID No. 303) is known.

[0113] As used herein, the term "hsa-miR-6805-5p gene" or "hsa-mi R-6805-5p" refers to the hsa-miR-6805- 5p gene (miRBase Accession No. MIMAT0027510) described in SEQ ID NO: 34 and includes other species homologs or orthologs, etc. hsa-miR-6805 The -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-m iR-6805-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6805" (miRBase Accession No. MI0022650, SEQ ID No. 304) is known.

[0114] As used herein, the term "hsa-miR-4728-5p gene" or "hsa-mi R-4728-5p" refers to the hsa-miR-4728- 5p gene (miRBase Accession No. MIMAT0019849) described in SEQ ID NO: 35 and also includes homologs or orthologs of other species. The hsa-miR-4728 -5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71, p78-86. Also, "hsa-miR-4 728-5p" has a hairpin-like structure as its precursor, "hsa-mir-4728 " (miRBase Accession No. MI0017365, SEQ ID NO: 305 ) is known.

[0115] As used herein, the term "hsa-miR-6726-5p gene" or "hsa-mi R-6726-5p" refers to the hsa-miR-6726- 5p gene (miRBase Accession No. MIMAT0027353) described in SEQ ID NO: 36 and also includes homologs or orthologs of other species. The hsa-miR-6726 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, It can be obtained by the method described in p1634-1645. Also, "hsa-m iR-6726-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6726" (miRBase Accession No. MI0022571, SEQ ID NO: 306) is known.

[0116] As used herein, the term "hsa-miR-197-5p gene" or "hsa-miR -197-5p" includes the hsa-miR-197-5p gene (miRBase Accession No. MIMAT0022691) described in SEQ ID NO: 37, and its homologs or orthologs in other species. The hsa-miR-197-5p gene can be obtained by the method described in Lagos-Quintana M et al., 2003, RNA, 9, p175- 179. Also, "hsa-miR-197- 5p" has a hairpin-like structure as its precursor, "hsa-mir-197" (miR Base Accession No. MI0000239, SEQ ID NO: 307) is known and is. te. ing.

[0117] As used herein, the term "hsa-miR-149-3p gene" or "hsa-miR -149-3p" includes the hsa-miR-149-3p gene (miRBase Accession No. MIMAT0004609) described in SEQ ID NO: 38, and its homologs or orthologs in other species. The hsa-miR-149-3p gene can be obtained by the method described in Lagos-Quintana M et al., 2002, Curr Biol, 12 vol., p735-739. Also, "hsa-m iR-149-3p" has a hairpin-like structure as its precursor, "hsa-mir-149" (miR Base Accession No. MI0000114, SEQ ID NO: 308) is known "iR-149-3p" has a hairpin-like structure as its precursor, "hsa-mir-1" 49" (miRBase Accession No. MI0000478, SEQ ID NO: 3 08) is known.

[0118] As used herein, the term "hsa-miR-6850-5p gene" or "hsa-mi R-6850-5p" refers to the hsa-miR-6850- 5p gene (miRBase Accession No. MIMAT0027600) described in SEQ ID NO: 39 and also includes other species homologs or orthologs, etc. The hsa-miR-6850 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-m iR-6850-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6850" (miRBase Accession No. MI0022696, SEQ ID NO 309) is known.

[0119] As used herein, the term "hsa-miR-4476 gene" or "hsa-miR-4 476" refers to the hsa-miR-4476 gene (miR Base Accession No. MIMAT0019003) described in SEQ ID NO: 40 and also includes other species homo logs or orthologs, etc. The hsa-miR-4476 gene can be obtained by the method described in Jima DD et al., 2010, Blood, 116, e118-e127. Also, "hsa-miR-4476" has a hairpin-like structure as its pre cursor, "hsa-mir-4476" (miRBase Accessio n No. MI0019003) n No.MI0016828, SEQ ID NO: 310) is known.

[0120] As used herein, the term "hsa-miR-6858-5p gene" or "hsa-mi R-6858-5p" refers to the hsa-miR-6858- 5p gene (miRBase Accession No.MIMAT0027616) described in SEQ ID NO: 41 and also includes other species homologs or orthologs, etc. The hsa-miR-6858 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-m iR-6858-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6858" (miRBase Accession No.MI0022704, SEQ ID NO: 311) is known.

[0121] As used herein, the term "hsa-miR-564 gene" or "hsa-miR-56 4" refers to the hsa-miR-564 gene (miRBase Accession No.MIMAT0003228) described in SEQ ID NO: 42 and also includes other species homologs or orthologs, etc. The hsa-miR-564 gene can be obtained by the method described in Cummins JM et al., 2006, Proc Natl Acad Sci U S A, 103, p3687-3692. Also, "hsa-m iR-564" has a hairpin-like structure as its precursor, "hsa-mir-564" (miRBase Accession No.MI0003570, SEQ ID NO: 312) is known. (miRBase Accession No.MI0003570, SEQ ID NO: 312) is known.

[0122] As used herein, the term "hsa-miR-4763-3p gene" or "hsa-mi R-4763-3p" refers to the hsa-miR-4763- 3p gene (miRBase Accession No. MIMAT0019913) described in SEQ ID NO: 43 and includes other species homologs or orthologs, etc. The hsa-miR-4763 -3p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71, pp78-86. Also, "hsa-miR-4 763-3p" has a hairpin-like structure as its precursor, "hsa-mir-4763 " (miRBase Accession No. MI0017404, SEQ ID NO: 313 ).

[0123] As used herein, the term "hsa-miR-575 gene" or "hsa-miR-57 5" refers to the hsa-miR-575 gene (miRBas e Accession No. MIMAT0003240) described in SEQ ID NO: 44 and other species homologs or orthologs, etc. The hsa-miR-575 gene can be obtained by the method described in Cummins JM et al., 2006, Proc Natl Acad Sci U S A, 103, pp3687-3692. Also, "hsa-m iR-575" has a hairpin-like structure as its precursor, "hsa-mir-575" (miRBase Accession No. MI0003582, SEQ ID NO: 314) is known.

[0124] As used herein, the term "hsa-miR-6771-5p gene" or "hsa-mi The term "R-6771-5p" refers to the hsa-miR-6771- 5p gene (miRBase Accession No. MIMAT0027442) and includes other species homologs or orthologs, etc. The hsa-miR-6771 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, pp1634-1645. Also, "hsa-m iR-6771-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6771" (miRBase Accession No. MI0022616, SEQ ID No. 315) is known.

[0125] As used herein, the term "hsa-miR-1231 gene" or "hsa-miR-1 231" refers to the hsa-miR-1231 gene (miR Base Accession No. MIMAT0005586) described in SEQ ID NO: 46 and includes other species homo logs or orthologs, etc. The hsa-miR-1231 gene can be obtained by the method described in Bere zikov E et al., 2007, Mol Cell, 28, pp328-336. Also, "hsa-miR-1231" has a hairpin-like structure as its precursor, "hsa-mir-1231" (miRBase Acc ession No. MI0006321, SEQ ID NO: 316) is known.

[0126] As used herein, the term "hsa-miR-1908-3p gene" or "hsa-mi R-1908-3p" refers to the hsa-miR-1908- 3p gene (miRBase Accession No. MIMAT0026916) and other species homologs or orthologs, etc. are included. hsa-miR-1908 -3p gene can be obtained by the method described by Bar M et al., 2008, Stem Cells, Vol. 26, p249 6-2505. Also, "hsa-miR-1 908-3p" has a hairpin-like structure as its precursor, "hsa-mir-1908 " (miRBase Accession No. MI0008329, SEQ ID NO: 317 ) is known.

[0127] As used herein, the term "hsa-miR-150-3p gene" or "hsa-miR -150-3p" includes the hsa-miR-150-3p gene described in SEQ ID NO: 48 (miRBase Accession No. MIMAT0004610) and its other species homologs or orthologs, etc. The hsa-miR-150-3p gene can be obtained by the method described by Lagos-Quintana M et al., 2002, Curr Biol, 12 Vol., p735-739. Also, "hsa-m iR-150-3p" has a hairpin-like structure as its precursor, "hsa-mir-1 50" (miRBase Accession No. MI0000479, SEQ ID NO: 3 18) is known.

[0128] As used herein, the term "hsa-miR-3937 gene" or "hsa-miR-3 937" includes the hsa-miR-3937 gene described in SEQ ID NO: 49 (miR Base Accession No. MIMAT0018352) and other species homologs ​Includes logs or orthologs, etc. The hsa-miR-3937 gene was described by Liao JY et al. in 2010 in PLoS One, Volume 5, e10563 by the method described therein. Also, "hsa-miR-3937" has a hairpin-like structure as its precursor, "hsa-mir-3937" (miRBase Accession No. MI0016593, SEQ ID NO: 319) is known.

[0129] As used herein, the term "hsa-miR-887-3p gene" or "hsa-miR -887-3p" includes the hsa-miR-887-3p gene (miRBase Accession No. MIMAT0004951) described in SEQ ID NO: 50 and its homologs or orthologs of other species, etc. The hsa-miR-887-3p gene can be obtained by the method described by Berezikov E et al. in 2006 in Genome Res, Volume 16, p1 289-1298. Also, "hsa-miR -887-3p" has a hairpin-like structure as its precursor, "hsa-mir-887 " (miRBase Accession No. MI0005562, SEQ ID NO: 320 ) is known.

[0130] As used herein, the term "hsa-miR-3940-5p gene" or "hsa-mi R-3940-5p" includes the hsa-miR-3940- 5p gene (miRBase Accession No. MIMAT0019229) described in SEQ ID NO: 51 and homologs or orthologs of other species, etc. The hsa-miR-3940 -5p gene was described by Liao JY et al. in 2010 in PLoS One, Volume 5, e1056​​ It can be obtained by the method described in 3. Also, "hsa-miR-3940-5 p" has a hairpin-like structure as its precursor, "hsa-mir-3940" (miR Base Accession No. MI0016597, SEQ ID NO: 321) is known to be.

[0131] As used herein, the term "hsa-miR-4741 gene" or "hsa-miR-4 741" refers to the hsa-miR-4741 gene described in SEQ ID NO: 52 (miR Base Accession No. MIMAT0019871) and other homologs or orthologs of other species. The hsa-miR-4741 gene can be obtained by the method described in Pers son H et al., 2011, Cancer Res, 71, p78-86. Also, "hsa-miR-4741" has a hairpin-like structure as its precursor, "hsa-mir-4741" (miRBase Acces sion No. MI0017379, SEQ ID NO: 322) is known.

[0132] As used herein, the term "hsa-miR-6808-5p gene" or "hsa-mi R-6808-5p" refers to the hsa-miR-6808- 5p gene described in SEQ ID NO: 53 (miRBase Accession No. MIMAT0027516) and other homologs or orthologs of other species. The hsa-miR-6808 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-m "iR-6808-5p" has, as its precursor, "hsa-mir- 6808" (miRBase Accession No. MI0022653, SEQ ID NO: 323) which is known.

[0133] As used herein, the term "hsa-miR-6869-5p gene" or "hsa-mi R-6869-5p" refers to the hsa-miR-6869- 5p gene (miRBase Accession No. MIMAT0027638) described in SEQ ID NO: 54 and includes other species homologs or orthologs, etc. The hsa-miR-6869 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, pp1634-1645. Also, "hsa-m iR-6869-5p" has, as its precursor, "hsa-mir- 6869" (miRBase Accession No. MI0022716, SEQ ID NO: 324) which is known.

[0134] As used herein, the term "hsa-miR-5090 gene" or "hsa-miR-5 090" refers to the hsa-miR-5090 gene (miR Base Accession No. MIMAT0021082) described in SEQ ID NO: 55 and includes other species homologs or orthologs, etc. The hsa-miR-5090 gene can be obtained by the method described in Ding N et al., 2011, J Radiat Res, 52, pp425-432 and "hsa-miR-5090" has, as its precursor, "hsa-mir-5090" which has a hairpin-like structure (miRBase Acce ssion No. MI0017979, SEQ ID NO: 325) is known.

[0135] As used herein, the term "hsa-miR-615-5p gene" or "hsa-miR -615-5p" includes the hsa-miR-615-5p gene (miRBase Accession No. MIMAT0004804) described in SEQ ID NO: 56 and its homologs or orthologs in other species. The hsa-miR-615-5p gene can be obtained by the method described in Cummins JM et al., 2006, Proc Natl Acad Sci USA, Vol. 103, p3687-3692. Also, "hsa-miR-615-5p" has a hairpin-like structure as its precursor "hsa-mir-615" (miRBase Accession No. MI0 003628, SEQ ID NO: 326) is known.

[0136] As used herein, the term "hsa-miR-8072 gene" or "hsa-miR-8 072" includes the hsa-miR-8072 gene (miR Base Accession No. MIMAT0030999) described in SEQ ID NO: 57 and its homologs or orthologs in other species. The hsa-miR-8072 gene can be obtained by the method described in Wang HJ et al., 2013, Shock, Vol. 39, p480-487. Also, "hsa-miR-8072" has a hairpin -like structure as its precursor "hsa-mir-8072" (miRBase Accession No. MI0025908, SEQ ID NO: 327) is known.

[0137] As used herein, the term "hsa-miR-128-1-5p gene" or "hsa-m iR-128-1-5p" includes the hsa-miR-128 -1-5p gene (miRBase Accession No. MIMAT00264 77) described in SEQ ID NO: 58, as well as homologs or orthologs of other species. The hsa-miR-1 28-1-5p gene can be obtained by the method described in Lagos-Quintana M et al., 2002, Curr Biol, Vol. 12, p735-739. Also, "hsa-miR-128-1-5p" takes a hairpin-like structure as its precursor "hsa-mir-128-1" (miRBase Accession No. MI0 000447, SEQ ID NO: 328) is known.

[0138] As used herein, the term "hsa-miR-1238-5p gene" or "hsa-mi R-1238-5p" includes the hsa-miR-1238- 5p gene (miRBase Accession No. MIMAT0022947) and homologs or orthologs of other species. The hsa-miR-1238 -5p gene can be obtained by the method described in Berezikov E et al., 2007, Mol Cell, Vol. 28, p328-336. Also, "hsa-miR -1238-5p" takes a hairpin-like structure as its precursor "hsa-mir-12 38" (miRBase Accession No. MI0006328, SEQ ID NO: 3 29) is known.

[0139] As used herein, the term "hsa-miR-365a-5p gene" or "hsa-mi The term "R-365a-5p" includes the hsa-miR-365a- 5p gene (miRBase Accession No. MIMAT0009199) described in SEQ ID NO: 60 and other homologs or orthologs of other species. The hsa-miR-365a -5p gene can be obtained by the method described in Xie X et al., 2005, Nature, 434, p338-34 5. Also, "hsa-miR-365a-5 p" has a hairpin-like structure as its precursor, "hsa-mir-365a" (miR Base Accession No. MI0000767, SEQ ID NO: 330) is known to exist.

[0140] As used herein, the term "hsa-miR-204-3p gene" or "hsa-miR -204-3p" includes the hsa-miR-204-3p gene (miRBase Accession No. MIMAT0022693) described in SEQ ID NO: 61 and other homologs or orthologs of other species. The hsa-miR-204-3p gene can be obtained by the method described in Lim LP et al., 2003, Science, 299, p1540 Also, "hsa-miR-204-3p" has a hairpin-like structure as its precursor, "hsa-mir-204" (miRBase Ac cession No. MI0000284, SEQ ID NO: 331) is known. As used herein, the term "hsa-miR-4492 gene" or "hsa-miR-4 492" includes the hsa-miR-4492 gene (miR

[0141] described in SEQ ID NO: 62 and miR Base Accession No. (MIMAT0019027) and other homologs of the species including logs or orthologs, etc. The hsa-miR-4492 gene was obtained by the method described by Jima DD et al., 2010, Blood, Vol. 116, pp. e118 - e127. Also, "hsa-miR-4492" has a hairpin-like structure as its precursor, "hsa-mir-4492" (miRBase Accession No. MI0016854, SEQ ID NO: 332) is known.

[0142] As used herein, the term "hsa-miR-6785-5p gene" or "hsa-miR-6785-5p" refers to the hsa-miR-6785-5p gene (miRBase Accession No. MIMAT0027470) described in SEQ ID NO: 63 and includes other homologs or orthologs of the species. The hsa-miR-6785-5p gene can be obtained by the method described by Ladewig E et al., 2012, Genome Res, Vol. 22, pp. 1634 - 1645. Also, "hsa-miR-6785-5p" has a hairpin-like structure as its precursor, "hsa-mir-6785" (miRBase Accession No. MI0022630, SEQ ID NO: 333) is known.

[0143] As used herein, the term "hsa-miR-6511a-5p gene" or "hsa-miR-6511a-5p" refers to the hsa-miR-6511a-5p gene (miRBase Accession No. MIMAT00254) described in SEQ ID NO: 64 78) and also includes other species homologs or orthologs, etc. hsa-miR-6 The 511a-5p gene can be obtained by the method described by Joyce CE et al., 2011, Hum Mol Gene t, 20 volumes, p4025 - 4040. Also, "hsa-miR-6511a-5p" has a hairpin-like structure as its precursor, "h sa-mir-6511a-1, hsa-mir-6511a-2, hsa-mir-6 511a-3, hsa-mir-6511a-4" (miRBase Accessio n No.MI0022223, MI0023564, MI0023565, MI002 3566, SEQ ID NO: 334, 335, 336, 337) are known.

[0144] As used herein, the term "hsa-miR-4525 gene" or "hsa-miR-4 525" includes the hsa-miR-4525 gene (miR Base Accession No.MIMAT0019064) described in SEQ ID NO: 65 and other species homo logs or orthologs, etc. The hsa-miR-4525 gene can be obtained by the method described by Jima DD et al., 2010, Blood, 116 volumes, e118 - e127 by. Also, "hsa-miR-4525" has a he as a precursor, a pin-like structure, "hsa-mir-4525" (miRBase Accessio n No.MI0016892, SEQ ID NO: 338) is known.

[0145] As used herein, the term "hsa-miR-1915-5p gene" or "hsa-mi R-1915-5p" includes the hsa-miR-1915- 5p gene (miRBase Accession No. MIMAT0007891) and includes other species homologs or orthologs, etc. hsa-miR-1915 -5p gene can be obtained by the method described by Bar M et al., 2008, Stem Cells, Vol. 26, p249 6-2505. Also, "hsa-miR-1 915-5p" has a hairpin-like structure as its precursor, "hsa-mir-1915 " (miRBase Accession No. MI0008336, SEQ ID NO: 339 ) is known.

[0146] As used herein, the term "hsa-miR-3180 gene" or "hsa-miR-3 180" refers to the hsa-miR-3180 gene described in SEQ ID NO: 67 (miR Base Accession No. MIMAT0018178) and includes other species homo logs or orthologs, etc. The hsa-miR-3180 gene can be obtained by the method described by Creighton CJ et al., 2010, PLoS One, Vol. 5, e9637 . Also, "hsa-miR-3180" has a hairpin-like structure as its precursor "hsa-mir-3180-4, hsa-mir-3180- 5" (miRBase Accession No. MI0016408, MI0016 409, SEQ ID NO: 340, 341) is known.

[0147] As used herein, the term "hsa-miR-6879-5p gene" or "hsa-mi R-6879-5p" refers to the hsa-miR-6879- 5p gene described in SEQ ID NO: 68 (miRBase Accession No. MIMAT0027658) It includes hsa-miR-6879 and other species homologs or orthologs, etc. The -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, pp. 1634-1645. Also, "hsa-m iR-6879-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6879" (miRBase Accession No. MI0022726, SEQ ID No. 342) is known.

[0148] As used herein, the term "hsa-miR-1199-5p gene" or "hsa-mi R-1199-5p" refers to the hsa-miR-1199- 5p gene described in SEQ ID NO: 69 (miRBase Accession No. MIMAT0031119) and includes other species homologs or orthologs, etc. hsa-miR-1199 The -5p gene can be obtained by the method described in Salvi A et al., 2013, Int J Oncol, 42, p 391-402. Also, "hsa-miR- 1199-5p" has a hairpin-like structure as its precursor, "hsa-mir-119 9" (miRBase Accession No. MI0020340, SEQ ID No. 343) is known.

[0149] As used herein, the term "hsa-miR-6746-5p gene" or "hsa-mi R-6746-5p" refers to the hsa-miR-6746- 5p gene described in SEQ ID NO: 70 (miRBase Accession No. MIMAT0027392) and includes other species homologs or orthologs, etc. hsa-miR-6746 The -5p gene can be obtained by the method described by Ladewig E et al., 2012, Genome Res, 22, pp1634 - 1645. Also, "hsa-m iR-6746-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6746" (miRBase Accession No. MI0022591, SEQ ID No. 344) is known.

[0150] As used herein, the term "hsa-miR-711 gene" or "hsa-miR-71 1" includes the hsa-miR-711 gene described in SEQ ID NO: 71 (miRBas e Accession No. MIMAT0012734) and other species homologs or orthologs, etc. The hsa-miR-711 gene can be obtained by the method described by Artzi S et al., 2008, BMC Bioinformatics, 9, p39 . Also, "hsa-miR-711" has a he re hairpin-like structure as its precursor, "hsa-mir-711" (miRBase Accession No. MI0012488, SEQ ID NO: 345) is known.

[0151] As used herein, the term "hsa-miR-663b gene" or "hsa-miR-6 63b" includes the hsa-miR-663b gene described in SEQ ID NO: 72 (miR Base Accession No. MIMAT0005867) and other species homologs or orthologs, etc. The hsa-miR-663b gene was described by Taka da S et al., 2008, Leukemia, 22, pp1274 - 1278 It can be obtained by the method. Also, "hsa-miR-663b" is its precursor "hsa-mir-663b" (miRBase Accession No.MI0006336, SEQ ID NO: 346) which has a hairpin-like structure as is known.

[0152] As used herein, the term "hsa-miR-4707-3p gene" or "hsa-mi R-4707-3p" refers to the hsa-miR-4707- 3p gene (miRBase Accession No.MIMAT0019808) described in SEQ ID NO: 73 and also includes other species homologs or orthologs, etc. The hsa-miR-4707 -3p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, Vol. 71, pp78-86. Also, "hsa-miR-4 707-3p" has a hairpin-like structure as its precursor "hsa-mir-4707 " (miRBase Accession No.MI0017340, SEQ ID NO: 347 ) is known.

[0153] As used herein, the term "hsa-miR-6893-5p gene" or "hsa-mi R-6893-5p" refers to the hsa-miR-6893- 5p gene (miRBase Accession No.MIMAT0027686) described in SEQ ID NO: 74 and also includes other species homologs or orthologs, etc. The hsa-miR-6893 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22, pp1634-1645. Also, "hsa-m "iR-6893-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6893" (miRBase Accession No. MI0022740, SEQ ID NO: 348) is known.

[0154] As used herein, the term "hsa-miR-4675 gene" or "hsa-miR-4 675" refers to the hsa-miR-4675 gene described in SEQ ID NO: 75 (miR Base Accession No. MIMAT0019757) and other homologs or orthologs of other species. The hsa-miR-4675 gene can be obtained by the method described by Pers son H et al., 2011, Cancer Res, 71, p78-86. Also, "hsa-miR-4675" has a hairpin-like structure as its precursor, "hsa-mir-4675" (miRBase Acces sion No. MI0017306, SEQ ID NO: 349) is known. sion No. MI0017306, SEQ ID NO: 349) is known.

[0155] As used herein, the term "hsa-miR-4638-5p gene" or "hsa-mi R-4638-5p" refers to the hsa-miR-4638- 5p gene described in SEQ ID NO: 76 (miRBase Accession No. MIMAT0019695) and other homologs or orthologs of other species. The hsa-miR-4638 -5p gene can be obtained by the method described by Persson H et al., 2011, Cancer Res, 71, p78-86. Also, "hsa-miR-4 638-5p" has a hairpin-like structure as its precursor, "hsa-mir-4638 」(miRBase Accession No. MI0017265, SEQ ID NO: 350 ) is known.

[0156] As used herein, the term "hsa-miR-4651 gene" or "hsa-miR-4 651" refers to the hsa-miR-4651 gene described in SEQ ID NO: 77 (miR Base Accession No. MIMAT0019715) and other homologous or orthologous genes of other species. The hsa-miR-4651 gene can be obtained by the method described in Pers son H et al., 2011, Cancer Res, Vol. 71, p78-86 . Also, "hsa-miR-4651" is "hsa-mir-4651" which forms a hairpin-like structure as its precursor (miRBase Acces sion No. MI0017279, SEQ ID NO: 351) and is known.

[0157] As used herein, the term "hsa-miR-6087 gene" or "hsa-miR-6 087" refers to the hsa-miR-6087 gene described in SEQ ID NO: 78 (miR Base Accession No. MIMAT0023712) and other homologous or orthologous genes of other species. The hsa-miR-6087 gene can be obtained by the method described in Yoo JK et al., 2012, Stem Cells Dev, Vol. 21, p2049-2057 . Also, "hsa-miR-6087" is "hsa-mir-6087" which forms a hairpin-like structure as its precursor (miRBase Accession No. MI0020364, SEQ ID NO: 352) and is known.

[0158] ​​​​As used herein, the term "hsa-miR-4665-5p gene" or "hsa-mi R-4665-5p" refers to the hsa-miR-4665- 5p gene (miRBase Accession No. MIMAT0019739) described in SEQ ID NO: 79 and includes other species homologs or orthologs, etc. The hsa-miR-4665 -5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71, pp78-86. Also, "hsa-miR-4 665-5p" has a hairpin-like structure as its precursor, "hsa-mir-4665 " (miRBase Accession No. MI0017295, SEQ ID NO: 353 ).

[0159] As used herein, the term "hsa-miR-4758-5p gene" or "hsa-mi R-4758-5p" refers to the hsa-miR-4758- 5p gene (miRBase Accession No. MIMAT0019903) and includes other species homologs or orthologs, etc. The hsa-miR-4758 -5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71, pp78-86. Also, "hsa-miR-4 758-5p" has a hairpin-like structure as its precursor, "hsa-mir-4758 " (miRBase Accession No. MI0017399, SEQ ID NO: 354 ).

[0160] As used herein, the term "hsa-miR-6887-5p gene" or "hsa-mi The term "R-6887-5p" refers to the hsa-miR-6887- 5p gene (miRBase Accession No. MIMAT0027674) and includes other species homologs or orthologs, etc. hsa-miR-6887 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-m iR-6887-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6887" (miRBase Accession No. MI0022734, SEQ ID No. 355) is known.

[0161] As used herein, the term "hsa-miR-3620-5p gene" or "hsa-mi R-3620-5p" refers to the hsa-miR-3620- 5p gene (miRBase Accession No. MIMAT0022967) and includes other species homologs or orthologs, etc. hsa-miR-3620 -5p gene can be obtained by the method described in Witten D et al., 2010, BMC Biol, 8, p58 . Also, "hsa-miR-3620-5p" has a hairpin-like structure as its precursor, "hsa-mir-3620" (miRBa se Accession No. MI0016011, SEQ ID No. 356) is known .

[0162] As used herein, the term "hsa-miR-1909-3p gene" or "hsa-mi R-1909-3p" refers to the hsa-miR-1909- 3p gene (miRBase Accession No. MIMAT0007883) and other species homologs or orthologs, etc. are included. hsa-miR-1909 -3p gene can be obtained by the method described in Bar M et al., 2008, Stem Cells, Vol. 26, p249 6 - 2505. Also, "hsa-miR-1 909-3p" has a hairpin-like structure as its precursor, "hsa-mir-1909 "(miRBase Accession No. MI0008330, SEQ ID NO: 357 ) is known.

[0163] As used herein, the term "hsa-miR-7641 gene" or "hsa-miR-7 641" refers to the hsa-miR-7641 gene (miR Base Accession No. MIMAT0029782) described in SEQ ID NO: 84 and other species homologs or orthologs, etc. are included. The hsa-miR-7641 gene can be obtained by the method described in Yoo JK et al., 2013, Arch Pharm Res, Vol. 36, p353 - 358 described. Also, "hsa-miR-7641" has "hsa-mir-7641-1, hsa-mir-7 641-2" (miRBase Accession No. MI0024975, MI 0024976, SEQ ID NO: 358, 359) with a hairpin-like structure as its precursor and is known.

[0164] As used herein, the term "hsa-miR-6724-5p gene" or "hsa-mi R-6724-5p" refers to the hsa-miR-6724- 5p gene (miRBase Accession No. MIMAT0025856) described in SEQ ID NO: 85​ including other species homologs or orthologs, etc. hsa-miR-6724 The -5p gene can be obtained by the method described in Li Y et al., 2012, Gene, Vol. 497, p330-335. Also, "hsa-miR-6724-5p" has a hairpin-like structure as its precursor, "hsa-mir-6724" (miRBase Accession No. MI0022559, SEQ ID NO: 360) is known .

[0165] As used herein, the term "hsa-miR-1343-3p gene" or "hsa-mi R-1343-3p" refers to the hsa-miR-1343- 3p gene (miRBase Accession No. MIMAT0019776) described in SEQ ID NO: 86 including other species homologs or orthologs, etc. hsa-miR-1343 The -3p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, Vol. 71, p78-86. Also, "hsa-miR-1 343-3p" has a hairpin-like structure as its precursor, "hsa-mir-1343 " (miRBase Accession No. MI0017320, SEQ ID NO: 361 ) is known.

[0166] As used herein, the term "hsa-miR-6780b-5p gene" or "hsa-m iR-6780b-5p" refers to the hsa-miR-678 0b-5p gene (miRBase Accession No. MIMAT00275 72) including other species homologs or orthologs, etc. hsa-miR-6 ​The 780b-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22, p1634-1645. Also, "h sa-miR-6780b-5p" has a hairpin-like structure as its precursor, "hsa -mir-6780b" (miRBase Accession No.MI00226 81, SEQ ID NO: 362) is known.

[0167] As used herein, the term "hsa-miR-4484 gene" or "hsa-miR-4 484" refers to the hsa-miR-4484 gene described in SEQ ID NO: 88 (miR Base Accession No.MIMAT0019018) and other homologous or orthologous genes in other species. The hsa-miR-4484 gene can be obtained by the method described in Jima DD et al., 2010, Blood, Vol. 116, e118-e127. Also, "hsa-miR-4484" has a hairpin-like structure as its precursor, "hsa-mir-4484" (miRBase Accessio n No.MI0016845, SEQ ID NO: 363) is known.

[0168] As used herein, the term "hsa-miR-4690-5p gene" or "hsa-mi R-4690-5p" refers to the hsa-miR-4690- 5p gene described in SEQ ID NO: 89 (miRBase Accession No.MIMAT0019779) and other homologous or orthologous genes in other species. The hsa-miR-4690 -5p gene is described in Persson H et al., 2011, Cancer Res, Vol. 71, It can be obtained by the method described on p78-86. Also, "hsa-miR-4 690-5p" has a hairpin-like structure as its precursor, "hsa-mir-4690 " (miRBase Accession No.MI0017323, SEQ ID NO: 364 ) is known.

[0169] As used herein, the term "hsa-miR-4429 gene" or "hsa-miR-4 429" refers to the hsa-miR-4429 gene described in SEQ ID NO: 90 (miR Base Accession No.MIMAT0018944) and other homologs or orthologs of other species. The hsa-miR-4429 gene can be obtained by the method described by Jima DD et al., 2010, Blood, Vol. 116, e118-e127. Also, "hsa-miR-4429" has a he pin-like structure as its precursor, "hsa-mir-4429" (miRBase Accessio n No.MI0016768, SEQ ID NO: 365) is known. pin-like structure as its precursor, "hsa-mir-4429" (miRBase Accessio n No.MI0016768, SEQ ID NO: 365) is known.

[0170] As used herein, the term "hsa-miR-1227-5p gene" or "hsa-mi R-1227-5p" refers to the hsa-miR-1227- 5p gene described in SEQ ID NO: 91 (miRBase Accession No.MIMAT0022941) and other homologs or orthologs of other species. The hsa-miR-1227 -5p gene can be obtained by the method described by Berezikov E et al., 2007, Mol Cell, Vol. 28, p328-336. Also, "hsa-miR "-1227-5p" has a hairpin-like structure as its precursor, "hsa-mir-12" "27" (miRBase Accession No. MI0006316, SEQ ID NO: 3 66) is known.

[0171] As used herein, the term "hsa-miR-4725-3p gene" or "hsa-mi R-4725-3p" refers to the hsa-miR-4725- 3p gene (miRBase Accession No. MIMAT0019844) described in SEQ ID NO: 92 and also includes homologs or orthologs of other species, etc. The hsa-miR-4725 -3p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71, p78-86. Also, "hsa-miR-4 725-3p" has a hairpin-like structure as its precursor, "hsa-mir-4725 " (miRBase Accession No. MI0017362, SEQ ID NO: 367 ) is known.

[0172] As used herein, the term "hsa-miR-6861-5p gene" or "hsa-mi R-6861-5p" refers to the hsa-miR-6861- 5p gene (miRBase Accession No. MIMAT0027623) described in SEQ ID NO: 93 and also includes homologs or orthologs of other species, etc. The hsa-miR-6861 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-m iR-6861-5p" has a hairpin-like structure as its precursor, "hsa-mir- "6861" (miRBase Accession No. MI0022708, sequence number 368) is known.

[0173] As used herein, the term "hsa-miR-6812-5p gene" or "hsa-mi R-6812-5p" refers to the hsa-miR-6812- 5p gene (miRBase Accession No. MIMAT0027524) described in SEQ ID NO: 94 and includes other species homologs or orthologs, etc. The hsa-miR-6812 -5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-m iR-6812-5p" has a hairpin-like structure as its precursor, "hsa-mir- 6812" (miRBase Accession No. MI0022657, sequence number 369) is known.

[0174] As used herein, the term "hsa-miR-3197 gene" or "hsa-miR-3 197" refers to the hsa-miR-3197 gene (miR Base Accession No. MIMAT0015082) described in SEQ ID NO: 95 and includes other species homo logs or orthologs, etc. The hsa-miR-3197 gene can be obtained by the method described in Star k MS et al., 2010, PLoS One, 5, e9685. Also, "hsa-miR-3197" has a hairpin -like structure as its precursor, "hsa-mir-3197" (miRBase Accession No. MI0014245, sequence number 370) is known.

[0175] As used herein, the term "hsa-miR-8059 gene" or "hsa-miR-8 059" refers to the hsa-miR-8059 gene described in SEQ ID NO: 96 (miR Base Accession No. MIMAT0030986) and other homologs or orthologs of other species. The hsa-miR-8059 gene can be obtained by the method described by Wang HJ et al., 2013, Shock, Vol. 39, p480-487. Also, "hsa-miR-8059" has a hairpin-like structure as its precursor, "hsa-mir-8059" (miRBase Accession No. MI0025895, SEQ ID NO: 371) is known.

[0176] As used herein, the term "hsa-miR-3185 gene" or "hsa-miR-3 185" refers to the hsa-miR-3185 gene described in SEQ ID NO: 97 (miR Base Accession No. MIMAT0015065) and other homologs or orthologs of other species. The hsa-miR-3185 gene can be obtained by the method described by Star k MS et al., 2010, PLoS One, Vol. 5, e9685. Also, "hsa-miR-3185" has a hairpin-like structure as its precursor, "hsa-mir-3185" (miRBase Accession No. MI0014227, SEQ ID NO: 372) is known.

[0177] As used herein, the term "hsa-miR-4706 gene" or "hsa-miR-4 706" refers to the hsa-miR-4706 gene described in SEQ ID NO: 98 (miR ​​​​​​Base Accession No. (MIMAT0019806) and other orthologs of the same gene in other species including logs or orthologs, etc. The hsa-miR-4706 gene can be obtained by the method described by Person H et al., 2011, Cancer Res, Vol. 71, p78-86. Also, "hsa-miR-4706" refers to "hsa-mir-4706" which forms a hairpin-like structure as its precursor (miRBase Accession No. MI0017339, SEQ ID NO: 373). Person H et al., 2011, Cancer Res, Vol. 71, p78-86 and can be obtained by the method described therein. Also, "hsa-miR-4706" refers to "hsa-mir-4706" which forms a hairpin-like structure as its precursor (miRBase Accession No. MI0017339, SEQ ID NO: 373). including logs or orthologs, etc. The hsa-miR-4497 gene can be obtained by the method described by Jima DD et al., 2010, Blood, Vol. 116, e118-e127. Also, "hsa-miR-4497" refers to "hsa-mir-4497" which forms a hairpin-like structure as its precursor (miRBase Accession No. MI0016859, SEQ ID NO: 374). is known.

[0178] As used herein, the term "hsa-miR-4497 gene" or "hsa-miR-4497" refers to the hsa-miR-4497 gene described in SEQ ID NO: 99 (miRBase Accession No. MIMAT0019032) and other orthologs or homologs in other species. including logs or orthologs, etc. The hsa-miR-4497 gene can be obtained by the method described by Jima DD et al., 2010, Blood, Vol. 116, e118-e127. Also, "hsa-miR-4497" refers to "hsa-mir-4497" which forms a hairpin-like structure as its precursor (miRBase Accession No. MI0016859, SEQ ID NO: 374). including logs or orthologs, etc. The hsa-miR-4497 gene can be obtained by the method described by Jima DD et al., 2010, Blood, Vol. 116, e118-e127. Also, "hsa-miR-4497" refers to "hsa-mir-4497" which forms a hairpin-like structure as its precursor (miRBase Accession No. MI0016859, SEQ ID NO: 374). including logs or orthologs, etc. The hsa-miR-4497 gene can be obtained by the method described by Jima DD et al., 2010, Blood, Vol. 116, e118-e127. Also, "hsa-miR-4497" refers to "hsa-mir-4497" which forms a hairpin-like structure as its precursor (miRBase Accession No. MI0016859, SEQ ID NO: 374). Jima DD et al., 2010, Blood, Vol. 116, e118-e127 and can be obtained by the method described therein. Also, "hsa-miR-4497" refers to "hsa-mir-4497" which forms a hairpin-like structure as its precursor (miRBase Accession No. MI0016859, SEQ ID NO: 374). including logs or orthologs, etc. The hsa-miR-3131 gene can be obtained by the method described by Sta et al. is known.

[0179] As used herein, the term "hsa-miR-3131 gene" or "hsa-miR-3131" refers to the hsa-miR-3131 gene described in SEQ ID NO: 100 (miRBase Accession No. MIMAT0014996) and other orthologs or homologs in other species. including logs or orthologs, etc. The hsa-miR-3131 gene can be obtained by the method described by Sta et al. including logs or orthologs, etc. The hsa-miR-3131 gene can be obtained by the method described by Sta et al. including logs or orthologs, etc. The hsa-miR-3131 gene can be obtained by the method described by Sta et al. rk MS et al., 2010, PLoS One, Vol. 5, e9685, can be obtained by the method described therein. Also, "hsa-miR-3131" has a hairpin-like structure as its precursor, "hsa-mir-3131" (miRBase Accession which can be obtained by the method described in rk MS et al., 2010, PLoS One, Vol. 5, e9685. Also, "hsa-miR-3131" has a hairpin-like structure as its precursor, "hsa-mir-3131" (miRBase Accession No.MI0014151, SEQ ID NO: 375) is known. No.MI0014151, SEQ ID NO: 375) is known.

[0180] As used herein, the term "hsa-miR-6806-5p gene" or "hsa-miR R-6806-5p" includes the hsa-miR-6806-5p gene (miRBase Accession No.MIMAT0027512 SEQ ID NO: 101) described in SEQ ID NO: 101, as well as other species homologs or orthologs, etc. The hsa-miR-680 ) and other species homologs or orthologs, etc. The hsa-miR-680 6-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22 , pp. 1634-1645. Also, "hsa- miR-6806-5p" has a hairpin-like structure as its precursor, "hsa-mir -6806" (miRBase Accession No.MI0022651, sequence SEQ ID NO: 376) is known.

[0181] As used herein, the term "hsa-miR-187-5p gene" or "hsa-miR -187-5p" includes the hsa-miR-187-5p gene (miRBase Accession No.MIMAT0004561) described in SEQ ID NO: 102 SEQ ID NO: 102) and other species homologs or orthologs, etc. The hsa-miR-187-5p gene includes the hsa-miR-187-5p gene (miRBase Accession No.MIMAT0004561) described in SEQ ID NO: 102 and other species homologs or orthologs, etc. The hsa-miR-187-5p gene was described in Lim LP et al., 2003, Science, Vol. 299, p. 1540 It can be obtained by the method to be described. Also, "hsa-miR-187-5p" has a hairpin-like structure as its precursor, "hsa-mir-187" (miRBase A ccession No.MI0000274, SEQ ID NO: 377) is known.

[0182] As used herein, the term "hsa-miR-3180-3p gene" or "hsa-mi R-3180-3p" includes the hsa-miR-3180-3p gene described in SEQ ID NO: 103 (miRBase Accession No.MIMAT0015058 ), as well as homologs or orthologs of other species. The hsa-miR-318 0-3p gene can be obtained by the method described in Creighton CJ et al., 2010, PLoS One, 5 volumes, e9637. Also, "hsa-miR-3 180-3p" has a hairpin-like structure as its precursor, "hsa-mir-3180 -1, hsa-mir-3180-2, hsa-mir-3180-3" (miRBas e Accession No.MI0014214, MI0014215, MI001 4217, SEQ ID NO: 378, 379, 380) is known.

[0183] As used herein, the term "hsa-miR-6848-5p gene" or "hsa-mi R-6848-5p" includes the hsa-miR-6848-5p gene described in SEQ ID NO: 104 (miRBase Accession No.MIMAT0027596 ), as well as homologs or orthologs of other species. The hsa-miR-684 8-5p gene is described in Ladewig E et al., 2012, Genome Res, 22 volumes ​​, can be obtained by the method described in p1634 - 1645. Also, "hsa - miR - 6848 - 5p" has a hairpin - like structure as its precursor, "hsa - mir -6848" (miRBase Accession No. MI0022694, sequence number 381) is known.

[0184] As used herein, the term "hsa - miR - 6820 - 5p gene" or "hsa - mi R - 6820 - 5p" includes the hsa - miR - 6820 -5p gene described in SEQ ID NO: 105 (miRBase Accession No. MIMAT0027540 ), as well as homologs or orthologs of other species. The hsa - miR - 682 0 - 5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634 - 1645. Also, "hsa - miR - 6820 - 5p" has a hairpin - like structure as its precursor, "hsa - mir -6820" (miRBase Accession No. MI0022665, sequence number 382) is known.

[0185] As used herein, the term "hsa - miR - 6800 - 5p gene" or "hsa - mi R - 6800 - 5p" includes the hsa - miR - 6800 -5p gene described in SEQ ID NO: 106 (miRBase Accession No. MIMAT0027500 ), as well as homologs or orthologs of other species. The hsa - miR - 680 0 - 5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634 - 1645. Also, "hsa - "miR-6800-5p" has a hairpin-like structure as its precursor, "hsa-mir" -6800" (miRBase Accession No. MI0022645, sequence number 383) is known.

[0186] As used herein, the term "hsa-miR-6717-5p gene" or "hsa-mi R-6717-5p" includes the hsa-miR-6717 -5p gene (miRBase Accession No. MIMAT0025846 ) described in SEQ ID NO: 107, as well as homologs or orthologs of other species. The hsa-miR-671 7-5p gene can be obtained by the method described in Li Y et al., 2012, Gene, 497, p330-335. Also, "hsa-miR-6717-5p" has a hairpin-like structure as its precursor, "hsa-mir-6717" (miRBa se Accession No. MI0022551, SEQ ID NO: 384) is known to be.

[0187] As used herein, the term "hsa-miR-6795-5p gene" or "hsa-mi R-6795-5p" includes the hsa-miR-6795 -5p gene (miRBase Accession No. MIMAT0027490 ) described in SEQ ID NO: 108, as well as homologs or orthologs of other species. The hsa-miR-679 5-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-6795-5p" has a hairpin-like structure as its precursor, "hsa-mir​ -6795」(miRBase Accession No.MI0022640, sequence No. 385) is known.

[0188] As used herein, the term "hsa-miR-4632-5p gene" or "hsa-mi R-4632-5p" includes the hsa-miR-4632-5p gene (miRBase Accession No.MIMAT0022977 ) described in SEQ ID NO: 109, as well as homologs or orthologs of other species. The hsa-miR-463 2-5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71: p78-86. Also, "hsa-miR- 4632-5p" has a hairpin-like structure as its precursor, "hsa-mir-463 2" (miRBase Accession No.MI0017259, SEQ ID NO: 38 6) is known. 6) is known.

[0189] As used herein, the term "hsa-miR-665 gene" or "hsa-miR-66 5" includes the hsa-miR-665 gene (miRBase Accession No.MIMAT0004952) described in SEQ ID NO: 110, as well as homologs of other species or orthologs. The hsa-miR-665 gene can be obtained by the method described in Berezik ov E et al., 2006, Genome Res, 16: p1289-1298. Also, "hsa-miR-665" has a hairpin-like structure as its precursor, "hsa-mir-665" (miRBase Accession No.MI0005563, SEQ ID NO: 387) is known. is known. precursor, "hsa-mir-665" (miRBase Accession No.MI0005563, SEQ ID NO: 387) is known. ssion No.MI0005563, SEQ ID NO: 387) is known.

[0190] As used herein, the term "hsa-miR-6778-5p gene" or "hsa-mi R-6778-5p" includes the hsa-miR-6778 -5p gene (miRBase Accession No. MIMAT0027456 ) described in SEQ ID NO: 111, as well as homologs or orthologs of other species. The hsa-miR-677 8-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-6778-5p" has a hairpin-like structure as its precursor, "hsa-mir -6778" (miRBase Accession No. MI0022623, sequence No. 388) is known.

[0191] As used herein, the term "hsa-miR-3663-3p gene" or "hsa-mi R-3663-3p" includes the hsa-miR-3663 -3p gene (miRBase Accession No. MIMAT0018085 ) described in SEQ ID NO: 112, as well as homologs or orthologs of other species. The hsa-miR-366 3-3p gene can be obtained by the method described in Liao JY et al., 2010, PLoS One, 5, e105 63. Also, "hsa-miR-3663- 3p" has a hairpin-like structure as its precursor, "hsa-mir-3663" (mi RBase Accession No. MI0016064, sequence No. 389) is known .

[0192] As used herein, the term "hsa-miR-4689 gene" or "hsa-miR-4 689" includes the hsa-miR-4689 gene (mi RBase Accession No. MIMAT0019778) described in SEQ ID NO: 113, as well as homologs or orthologs of other species. The hsa-miR-4689 gene can be obtained by the method described in Per sson H et al., 2011, Cancer Res, 71, p78-86. Also, "hsa-miR-4689" has a precursor that forms a hairpin-like structure, namely "hsa-mir-4689" (miRBase Acce ssion No. MI0017322, SEQ ID NO: 390). known as

[0193] As used herein, the term "hsa-miR-211-3p gene" or "hsa-miR -211-3p" includes the hsa-miR-211-3p gene (miRBase Accession No. MIMAT0022694) described in SEQ ID NO: 114, as well as homologs or orthologs of other species. The hsa-miR-211-3p gene can be obtained by the method described in Lim LP et al., 2003, Science, 299, p1540. Also, "hsa-miR-211-3p" has a precursor that forms a hairpin-like structure, namely "hsa-mir-211" (miRBase A ccession No. MI0000287, SEQ ID NO: 391). known as

[0194] As used herein, the term "hsa-miR-6511b-5p gene" or "hsa-m iR-6511b-5p" includes the hsa-miR-65 ​​The 11b-5p gene (miRBase Accession No. MIMAT0025 847) and other homologs or orthologs of other species are included. hsa-miR- 6511b-5p gene can be obtained by the method described in Li Y et al., 2012, Gene, Vol. 497, p330- 335. Also, "hsa-miR-6511 b-5p" takes a hairpin-like structure as its precursor, "hsa-mir-6511b- 1, hsa-mir-6511b-2" (miRBase Accession No. MI0022552, MI0023431, SEQ ID NO: 392, 393) is known.

[0195] As used herein, the term "hsa-miR-4750-5p gene" or "hsa-mi R-4750-5p" refers to the hsa-miR-4750 -5p gene described in SEQ ID NO: 116 (miRBase Accession No. MIMAT0019887 ) and other homologs or orthologs of other species are included. hsa-miR-475 0-5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, Vol. 71 , p78-86. Also, "hsa-miR- 4750-5p" takes a hairpin-like structure as its precursor, "hsa-mir-475 0" (miRBase Accession No. MI0017389, SEQ ID NO: 39 4) is known.

[0196] As used herein, the term "hsa-miR-6126 gene" or "hsa-miR-6 126" refers to the hsa-miR-6126 gene described in SEQ ID NO: 117 (mi RBase Accession No. (MIMAT0024599) and other homologs of the same species, etc. including paralogs or orthologs, etc. The hsa-miR-6126 gene can be obtained by the method described by Smi th JL et al., 2012, J Virol, 86, p5278-5287. Also, "hsa-miR-6126" has a hairpin-like structure as its precursor, "hsa-mir-6126" (miRBase Acce ssion No. MI0021260, SEQ ID NO: 395) is known. The term "hsa-miR-614 gene" or "hsa-miR-61 4" as used herein includes the hsa-miR-614 gene described in SEQ ID NO: 118 (miRBa

[0197] se Accession No. MIMAT0003282) and other homologs of the same species or orthologs, etc. The hsa-miR-614 gene can be obtained by the method described by Cummins JM et al., 2006, Proc Natl Acad Sci U S A, 103 , p3687-3692. Also, "hsa- miR-614" has a hairpin-like structure as its precursor, "hsa-mir-614 " (miRBase Accession No. MI0003627, SEQ ID NO: 396 ) is known.

[0198] The term "hsa-miR-7110-5p gene" or "hsa-mi R-7110-5p" as used herein includes the hsa-miR-7110 -5p gene described in SEQ ID NO: 119 (miRBase Accession No. MIMAT0028117 ​​It includes hsa-miR-711 and other species homologs or orthologs, etc. The 0-5p gene can be obtained by the method described by Ladewig E et al., 2012, Genome Res, Vol. 22 , pp. 1634-1645. Also, "hsa- miR-7110-5p" has a hairpin-like structure as its precursor, "hsa-mir -7110" (miRBase Accession No. MI0022961, sequence No. 397) is known.

[0199] As used herein, the term "hsa-miR-744-5p gene" or "hsa-miR -744-5p" includes the hsa-miR-744-5p gene (miRBase Accession No. MIMAT0004945) described in SEQ ID NO: 120 and other species homologs or orthologs, etc. hsa-miR-744-5p gene can be obtained by the method described by Berezikov E et al., 2006, Genome Res, Vol. 16, p 1289-1298. Also, "hsa-mi R-744-5p" has a hairpin-like structure as its precursor, "hsa-mir-74 4" (miRBase Accession No. MI0005559, SEQ ID NO: 39 8) is known.

[0200] As used herein, the term "hsa-miR-6769a-5p gene" or "hsa-m iR-6769a-5p" includes the hsa-miR-67 69a-5p gene (miRBase Accession No. MIMAT0027 438) described in SEQ ID NO: 121 and other species homologs or orthologs, etc. hsa-miR- The 6769a-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res , 22, p1634-1645. Also, " hsa-miR-6769a-5p" has a hairpin-like structure as its precursor, "hs a-mir-6769a" (miRBase Accession No.MI0022 614, SEQ ID NO: 399) is known.

[0201] As used herein, the term "hsa-miR-4792 gene" or "hsa-miR-4 792" includes the hsa-miR-4792 gene (mi RBase Accession No.MIMAT0019964) described in SEQ ID NO: 122 and other species homologs or orthologs, etc. The hsa-miR-4792 gene can be obtained by the method described in Per sson H et al., 2011, Cancer Res, 71, p78-86 . Also, "hsa-miR-4792" has a hairpin-like structure as its precursor "hsa-mir-4792" (miRBase Acce ssion No.MI0017439, SEQ ID NO: 400) is known.

[0202] As used herein, the term "hsa-miR-5787 gene" or "hsa-miR-5 787" includes the hsa-miR-5787 gene (mi RBase Accession No.MIMAT0023252) described in SEQ ID NO: 123 and other species homologs or orthologs, etc. The hsa-miR-5787 gene is described in Yoo H et al., 2011, Biochem Biophys Res Commun, 415 It can be obtained by the method described in Volume, pages 567 - 572. Also, "hsa-m" "iR-5787" has a hairpin-like structure as its precursor, "hsa-mir-578" "7" (miRBase Accession No. MI0019797, SEQ ID NO: 40 1) is known.

[0203] As used herein, the term "hsa-miR-6798-5p gene" or "hsa-mi "R-6798-5p" includes the hsa-miR-6798 -5p gene described in SEQ ID NO: 124 (miRBase Accession No. MIMAT0027496 ) and other species homologs or orthologs, etc. The hsa-miR-679 8-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22 , pages 1634 - 1645. Also, "hsa- "miR-6798-5p" has a hairpin-like structure as its precursor, "hsa-mir "-6798" (miRBase Accession No. MI0022643, sequence No. 402) is known.

[0204] As used herein, the term "hsa-miR-6781-5p gene" or "hsa-mi "R-6781-5p" includes the hsa-miR-6781 -5p gene described in SEQ ID NO: 125 (miRBase Accession No. MIMAT0027462 ) and other species homologs or orthologs, etc. The hsa-miR-678 1-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22 , pages 1634 - 1645. Also, "hsa- "miR-6781-5p" has a hairpin-like structure as its precursor, "hsa-mir" -6781" (miRBase Accession No. MI0022626, sequence number 403) is known.

[0205] As used herein, the term "hsa-miR-4419b gene" or "hsa-miR- 4419b" refers to the hsa-miR-4419b gene described in SEQ ID NO: 126 (miRBase Accession No. MIMAT0019034) and other biological species homologs or orthologs, etc. The hsa-miR-4419b gene is described in Jima DD et al., 2010, Blood, Vol. 116, e118-e127 and can be obtained by the method described therein. Also, "hsa-miR-4419b" has a hairpin-like structure as its precursor, "hsa-mir-4419b" (miRBase A ccession No. MI0016861, SEQ ID NO: 404) is known. ccession No. MI0016861, SEQ ID NO: 404) is known.

[0206] As used herein, the term "hsa-miR-4446-3p gene" or "hsa-mi R-4446-3p" refers to the hsa-miR-4446-3p gene described in SEQ ID NO: 127 (miRBase Accession No. MIMAT0018965 ) and other biological species homologs or orthologs, etc. The hsa-miR-444 6-3p gene can be obtained by the method described in Jima DD et al., 2010, Blood, Vol. 116, e118- e127. Also, "hsa-miR-4446-3p" has a hairpin-like structure as its precursor, "hsa-mir-4446"( ) miRBase Accession No. MI0016789, SEQ ID NO: 405) is known.

[0207] As used herein, the term "hsa-miR-4259 gene" or "hsa-miR-4 259" refers to the hsa-miR-4259 gene (mi RBase Accession No. MIMAT0016880) described in SEQ ID NO: 128 and other species homologs or orthologs, etc. The hsa-miR-4259 gene can be obtained by the method described by Gof f LA et al., 2009, PLoS One, Vol. 4, e7192. Also, "hsa-miR-4259" has a hairpin-like structure as its precursor, "hsa-mir-4259" (miRBase Accession No. MI0015858, SEQ ID NO: 406) is known.

[0208] As used herein, the term "hsa-miR-5572 gene" or "hsa-miR-5 572" refers to the hsa-miR-5572 gene (mi RBase Accession No. MIMAT0022260) described in SEQ ID NO: 129 and other species homologs or orthologs, etc. The hsa-miR-5572 gene can be obtained by the method described by Tan don M et al., 2012, Oral Dis, Vol. 18, p127-131. Also, "hsa-miR-5572" has a hairpin-like structure as its precursor, "hsa-mir-5572" (miRBase Acces sion No. MI0019117, SEQ ID NO: 407) is known.

[0209] ​​As used herein, "hsa-miR-6075 gene" or "hsa-miR-6 The term "miR-6075" refers to the hsa-miR-6075 gene (miR-6075) set forth in SEQ ID NO: 130. RBase Accession No. MIMAT0023700) and other species The hsa-miR-6075 gene is a member of the Voe The method described in Illenkle C et al., 2012, RNA, Vol. 18, p. 472-484 The precursor of hsa-miR-6075 is The hairpin-like structure of “hsa-mir-6075” (miRBase Accession No. ion No. MI0020352, sequence number 408) are known.

[0210] As used herein, "hsa-miR-296-3p gene" or "hsa-miR The term "miR-296-3p" refers to hsa-miR-296-3p as set forth in SEQ ID NO: 131. Gene (miRBase Accession No. MIMAT0004679) and hsa-miR-296-3p The gene is Houbaviy HB et al., 2003, Dev Cell, vol. 5, p. 351 The miR-296 can be obtained by the method described in 358, 360-361, 362-363, and 364-365. The precursor of α-3p is the hairpin-like structure hsa-mir-296 (mi RBase Accession No. MI0000747, sequence number 409) is known. It is being done.

[0211] As used herein, the term "hsa-miR-6891-5p gene" or "hsa-mi The term "miR-6891-5p" refers to hsa-miR-6891 as set forth in SEQ ID NO: 132. -5p gene (miRBase Accession No. MIMAT0027682 ) and other homologs or orthologs of other species are included. hsa-miR-689 The 1-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22nd volume , p1634-1645. Also, "hsa- miR-6891-5p" has a hairpin-like structure as its precursor, "hsa-mir -6891" (miRBase Accession No. MI0022738, sequence No. 410) is known.

[0212] As used herein, the term "hsa-miR-4745-5p gene" or "hsa-mi R-4745-5p" refers to the hsa-miR-4745 described in SEQ ID NO: 133 -5p gene (miRBase Accession No. MIMAT0019878 ) and other homologs or orthologs of other species are included. hsa-miR-474 The 5-5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71st volume , p78-86. Also, "hsa-miR- 4745-5p" has a hairpin-like structure as its precursor, "hsa-mir-474 5" (miRBase Accession No. MI0017384, SEQ ID NO: 41 1) is known.

[0213] As used herein, the term "hsa-miR-6775-5p gene" or "hsa-mi R-6775-5p" refers to the hsa-miR-6775 described in SEQ ID NO: 134 -5p gene (miRBase Accession No. MIMAT0027450 ) and other species homologs or orthologs, etc. hsa-miR-677 The 5-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22 , pp. 1634-1645. Also, "hsa- miR-6775-5p" has a hairpin-like structure as its precursor, "hsa-mir -6775" (miRBase Accession No. MI0022620, sequence No. 412) is known.

[0214] As used herein, the term "hsa-miR-6870-5p gene" or "hsa-mi R-6870-5p" refers to the hsa-miR-6870 described in SEQ ID NO: 135 -5p gene (miRBase Accession No. MIMAT0027640 ) and other species homologs or orthologs, etc. hsa-miR-687 The 0-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22 , pp. 1634-1645. Also, "hsa- miR-6870-5p" has a hairpin-like structure as its precursor, "hsa-mir -6870" (miRBase Accession No. MI0022717, sequence No. 413) is known.

[0215] As used herein, the term "hsa-miR-920 gene" or "hsa-miR-92 0" refers to the hsa-miR-920 gene described in SEQ ID NO: 136 (miRBa se Accession No. MIMAT0004970) and other species homologs or includes orthologs, etc. The hsa-miR-920 gene is described by Novotny GW et al., 2007, Int J Androl, Vol. 30, p316-326 and can be obtained by the method described therein. Also, "hsa-miR-920" has a hairpin-like structure as its precursor, "hsa-mir-920" (miRBase Access sion No. MI0005712, SEQ ID NO: 414) is known.

[0216] As used herein, the term "hsa-miR-4530 gene" or "hsa-miR-4 530" includes the hsa-miR-4530 gene described in SEQ ID NO: 137 (mi RBase Accession No. MIMAT0019069) and other species homologs or orthologs, etc. The hsa-miR-4530 gene can be obtained by the method described by Jim a DD et al., 2010, Blood, Vol. 116, e118-e127 and "hsa-miR-4530" has a hairpin-like structure as its precursor, "hsa-mir-4530" (miRBase Accessi on No. MI0016897, SEQ ID NO: 415) is known.

[0217] As used herein, the term "hsa-miR-6819-5p gene" or "hsa-mi R-6819-5p" includes the hsa-miR-6819 -5p gene described in SEQ ID NO: 138 (miRBase Accession No. MIMAT0027538 ) and other species homologs or orthologs, etc. The hsa-miR-681 9-5p gene is described by Ladewig E et al., 2012, Genome Res, Vol. 22 ​​, can be obtained by the method described in p1634-1645. Also, "hsa- miR-6819-5p" has a hairpin-like structure as its precursor, "hsa-mir -6819" (miRBase Accession No. MI0022664, sequence No. 416) is known.

[0218] As used herein, the term "hsa-miR-6825-5p gene" or "hsa-mi R-6825-5p" refers to the hsa-miR-6825 -5p gene described in SEQ ID NO: 139 (miRBase Accession No. MIMAT0027550 ) and other species homologs or orthologs, etc. The hsa-miR-682 5-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-6825-5p" has a hairpin-like structure as its precursor, "hsa-mir -6825" (miRBase Accession No. MI0022670, sequence No. 417) is known.

[0219] As used herein, the term "hsa-miR-7847-3p gene" or "hsa-mi R-7847-3p" refers to the hsa-miR-7847 -3p gene described in SEQ ID NO: 140 (miRBase Accession No. MIMAT0030422 ) and other species homologs or orthologs, etc. The hsa-miR-784 7-3p gene can be obtained by the method described in Ple H et al., 2012, PLoS One, 7, e50746 and can also be obtained by the method described in "hsa-miR-7847-3p " has, as its precursor, "hsa-mir-7847" which takes a hairpin-like structure (miRB ase Accession No. MI0025517, SEQ ID NO: 418) and is known .

[0220] As used herein, the term "hsa-miR-6131 gene" or "hsa-miR-6 131" includes the hsa-miR-6131 gene described in SEQ ID NO: 141 (mi RBase Accession No. MIMAT0024615) and other homologs or orthologs of other species, etc. The hsa-miR-6131 gene can be obtained by the method described in Dan nemann M et al., 2012, Genome Biol Evol, Vol. 4, p552 -564. Also, "hsa-miR-613 1" has, as its precursor, "hsa-mir-6131" which takes a hairpin-like structure (miR Base Accession No. MI0021276, SEQ ID NO: 419) and is known .

[0221] As used herein, the term "hsa-miR-4433-3p gene" or "hsa-mi R-4433-3p" includes the hsa-miR-4433 -3p gene described in SEQ ID NO: 142 (miRBase Accession No. MIMAT0018949 ) and other homologs or orthologs of other species, etc. The hsa-miR-443 3-3p gene can be obtained by the method described in Jima DD et al., 2010, Blood, Vol. 116, e118- e127. Also, "hsa-miR-443 3-3p" has, as its precursor, "hsa-mir-4433" which takes a hairpin-like structure ( ​miRBase Accession No. MI0016773, SEQ ID NO: 420) is known.

[0222] As used herein, the term "hsa-miR-1228-5p gene" or "hsa-mi R-1228-5p" refers to the hsa-miR-1228 -5p gene (miRBase Accession No. MIMAT0005582 ) described in SEQ ID NO: 143, as well as homologs or orthologs of other species. The hsa-miR-122 8-5p gene can be obtained by the method described in Berezikov E et al., 2007, Mol Cell, Vol. 28 , pp. 328-336. Also, "hsa-mi R-1228-5p" has a hairpin-like structure as its precursor, "hsa-mir-1 228" (miRBase Accession No. MI0006318, SEQ ID NO: 421) is known.

[0223] As used herein, the term "hsa-miR-6743-5p gene" or "hsa-mi R-6743-5p" refers to the hsa-miR-6743 -5p gene (miRBase Accession No. MIMAT0027387 ) described in SEQ ID NO: 144, as well as homologs or orthologs of other species. The hsa-miR-674 3-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22 , pp. 1634-1645. Also, "hsa- miR-6743-5p" has a hairpin-like structure as its precursor, "hsa-mir -6743" (miRBase Accession No. MI0022588, SEQ Number 422) is known.

[0224] As used herein, the term "hsa-miR-1268a gene" or "hsa-miR- 1268a" includes the hsa-miR-1268a gene described in SEQ ID NO: 145 (miRBase Accession No. MIMAT0005922) and other homologous or orthologous genes of other species. The hsa-miR-1268a gene can be obtained by the method described in Morin RD et al., 2008, Genome Res, 18, p610-621 . Also, "hsa-miR-1268a" is "hsa-mir-1268a" (miRBase Accession No. MI0006405, SEQ ID NO: 423), which has a hairpin-like structure as its precursor, is known .

[0225] As used herein, the term "hsa-miR-3917 gene" or "hsa-miR-3 917" includes the hsa-miR-3917 gene described in SEQ ID NO: 146 (mi RBase Accession No. MIMAT0018191) and other homologous or orthologous genes of other species. The hsa-miR-3917 gene can be obtained by the method described in Creighton CJ et al., 2010, PLoS One, 5, e9637 . Also, "hsa-miR-3917" is "hsa-mir-3917" (miRBase Accession No. MI0016423, SEQ ID NO: 424), which has a hairpin-like structure as its precursor, is known .

[0226] As used herein, the term "hsa-miR-6786-5p gene" or "hsa-mi The term "R-6786-5p" refers to hsa-miR-6786 -5p gene (miRBase Accession No. MIMAT0027472 ) and also includes other species homologs or orthologs, etc. hsa-miR-678 6-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-6786-5p" has a hairpin-like structure as its precursor, "hsa-mir -6786" (miRBase Accession No. MI0022631, sequence No. 425) is known.

[0227] As used herein, the term "hsa-miR-3154 gene" or "hsa-miR-3 154" refers to the hsa-miR-3154 gene described in SEQ ID NO: 148 (mi RBase Accession No. MIMAT0015028) and also includes other species ho mologs or orthologs, etc. The hsa-miR-3154 gene can be obtained by the method described in Ber ezikov E et al., 2006, Genome Res, 16, p1289-129 8. Also, "hsa-miR-3154" has a hairpin-like structure as its precursor, "hsa-mir-3154" (miRBas e Accession No. MI0014182, SEQ ID NO: 426) is known .

[0228] As used herein, the term "hsa-miR-638 gene" or "hsa-miR-63 8" refers to the hsa-miR-638 gene described in SEQ ID NO: 149 (miRBa se Accession No.MIMAT0003308) and other species homologs or orthologs, etc. The hsa-miR-638 gene can be obtained by the method described in Cummins JM et al., 2006, Proc Natl Acad Sci U S A, Vol. 103 , pp. 3687 - 3692. Also, "hsa- miR-638" has a hairpin-like structure as its precursor, "hsa-mir-638 " (miRBase Accession No.MI0003653, SEQ ID NO: 427 ).

[0229] As used herein, the term "hsa-miR-6741-5p gene" or "hsa-mi R-6741-5p" includes the hsa-miR-6741 -5p gene described in SEQ ID NO: 150 (miRBase Accession No.MIMAT0027383 ) and other species homologs or orthologs, etc. The hsa-miR-674 1-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22 , pp. 1634 - 1645. Also, "hsa- miR-6741-5p" has a hairpin-like structure as its precursor, "hsa-mir -6741" (miRBase Accession No.MI0022586, sequence No. 428).

[0230] As used herein, the term "hsa-miR-6889-5p gene" or "hsa-mi R-6889-5p" includes the hsa-miR-6889 -5p gene described in SEQ ID NO: 151 (miRBase Accession No.MIMAT0027678 ) and other species homologs or orthologs, etc. are included. hsa-miR-688 The 9-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp. 1634-1645. Also, "hsa- miR-6889-5p" has a hairpin-like structure as its precursor, "hsa-mir -6889" (miRBase Accession No. MI0022736, sequence number 429) is known.

[0231] As used herein, the term "hsa-miR-6840-3p gene" or "hsa-mi R-6840-3p" includes the hsa-miR-6840 -3p gene described in SEQ ID NO: 152 (miRBase Accession No. MIMAT0027583 ) and other species homologs or orthologs, etc. hsa-miR-684 The 0-3p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp. 1634-1645. Also, "hsa- miR-6840-3p" has a hairpin-like structure as its precursor, "hsa-mir -6840" (miRBase Accession No. MI0022686, sequence number 430) is known.

[0232] As used herein, the term "hsa-miR-6510-5p gene" or "hsa-mi R-6510-5p" includes the hsa-miR-6510 -5p gene described in SEQ ID NO: 153 (miRBase Accession No. MIMAT0025476 ) and other species homologs or orthologs, etc. hsa-miR-651 The 0-5p gene can be obtained by the method described by Joyce CE et al., 2011, Hum Mol Genet, 2 0 volumes, p4025-4040. Also, "hs a-miR-6510-5p" has a hairpin-like structure as its precursor, "hsa-m ir-6510" (miRBase Accession No. MI0022222, SEQ ID NO: 431) is known.

[0233] As used herein, the term "hsa-miR-3188 gene" or "hsa-miR-3 188" includes the hsa-miR-3188 gene described in SEQ ID NO: 154 (mi RBase Accession No. MIMAT0015070) and other homologs or orthologs of other species. The hsa-miR-3188 gene can be obtained by the method described by Sta rk MS et al., 2010, PLoS One, 5 volumes, e9685. Also, "hsa-miR-3188" has a hair pin-like structure as its precursor, "hsa-mir-3188" (miRBase Accession No. MI0014232, SEQ ID NO: 432) is known. pin-like structure as its precursor, "hsa-mir-3188" (miRBase Accession No. MI0014232, SEQ ID NO: 432) is known.

[0234] As used herein, the term "hsa-miR-551b-5p gene" or "hsa-mi R-551b-5p" includes the hsa-miR-551b described in SEQ ID NO: 155 -5p gene (miRBase Accession No. MIMAT0004794 ) and other homologs or orthologs of other species. The hsa-miR-551 b-5p gene was described by Cummins JM et al., 2006, Proc Natl Aca It can be obtained by the method described in d Sci U S A, Vol. 103, pp. 3687-3692. Moreover, "hsa-miR-551b-5p" has, as its precursor, "hsa-mir-551b" which takes a hairpin-like structure (miRBase Accession No. MI0003575, SEQ ID NO: 433) is known.

[0235] As used herein, the term "hsa-miR-5001-5p gene" or "hsa-mi R-5001-5p" includes the hsa-miR-5001-5p gene (miRBase Accession No. MIMAT0021021 ) described in SEQ ID NO: 156, as well as other species homologs or orthologs, etc. The hsa-miR-500 1-5p gene can be obtained by the method described in Hansen TB et al., 2011, RNA Biol, Vol. 8, pp. 3 78-383. Moreover, "hsa-miR-5 001-5p" has, as its precursor, "hsa-mir-5001" which takes a hairpin-like structure (miRBase Accession No. MI0017867, SEQ ID NO: 434 ) is known.

[0236] As used herein, the term "hsa-miR-1268b gene" or "hsa-miR- 1268b" includes the hsa-miR-1268b gene described in SEQ ID NO: 157 (miRBase Accession No. MIMAT0018925) and other biological species homologs or orthologs, etc. The hsa-miR-1268b gene is described in Jima DD et al., 2010, Blood, Vol. 116, e118-e127. can be obtained by the method. Also, "hsa-miR-1268b" is preceded by "hsa-mir-1268b" (miRBase A ccession No. MI0016748, SEQ ID NO: 435) which takes a hairpin-like structure as its precursor is known.

[0237] As used herein, the term "hsa-miR-7107-5p gene" or "hsa-mi R-7107-5p" includes the hsa-miR-7107 -5p gene (miRBase Accession No. MIMAT0028111 ) described in SEQ ID NO: 158, as well as homologs or orthologs of other species. The hsa-miR-710 7-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp1634-1645. Also, "hsa- miR-7107-5p" takes a hairpin-like structure as its precursor "hsa-mir -7107" (miRBase Accession No. MI0022958, sequence NO: 436) is known.

[0238] As used herein, the term "hsa-miR-6824-5p gene" or "hsa-mi R-6824-5p" includes the hsa-miR-6824 -5p gene (miRBase Accession No. MIMAT0027548 ) described in SEQ ID NO: 159, as well as homologs or orthologs of other species. The hsa-miR-682 4-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp1634-1645. Also, "hsa- "miR-6824-5p" has a hairpin-like structure as its precursor, "hsa-mir" -6824" (miRBase Accession No. MI0022669, sequence No. 437) is known.

[0239] As used herein, the term "hsa-miR-6732-5p gene" or "hsa-mi R-6732-5p" includes the hsa-miR-6732 -5p gene described in SEQ ID NO: 160 (miRBase Accession No. MIMAT0027365 ), as well as homologs or orthologs of other species. The hsa-miR-673 2-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-6732-5p" has a hairpin-like structure as its precursor, "hsa-mir -6732" (miRBase Accession No. MI0022577, sequence No. 438) is known.

[0240] As used herein, the term "hsa-miR-371a-5p gene" or "hsa-mi R-371a-5p" includes the hsa-miR-371a -5p gene described in SEQ ID NO: 161 (miRBase Accession No. MIMAT0004687 ), as well as homologs or orthologs of other species. The hsa-miR-371 a-5p gene can be obtained by the method described in Suh MR et al., 2004, Dev Biol, 270, p48 8-498. Also, "hsa-miR-37 1a-5p" has a hairpin-like structure as its precursor, "hsa-mir-371a" (miRBase Accession No.MI0000779, SEQ ID NO: 439) is known.

[0241] As used herein, the term "hsa-miR-6794-5p gene" or "hsa-mi R-6794-5p" refers to the hsa-miR-6794 -5p gene (miRBase Accession No.MIMAT0027488 ) described in SEQ ID NO: 162, as well as homologs or orthologs of other species. The hsa-miR-679 4-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp. 1634-1645. Also, "hsa- miR-6794-5p" has a hairpin-like structure as its precursor, "hsa-mir -6794" (miRBase Accession No.MI0022639, sequence NO: 440) is known.

[0242] As used herein, the term "hsa-miR-6779-5p gene" or "hsa-mi R-6779-5p" refers to the hsa-miR-6779 -5p gene (miRBase Accession No.MIMAT0027458 ) described in SEQ ID NO: 163, as well as homologs or orthologs of other species. The hsa-miR-677 9-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp. 1634-1645. Also, "hsa- miR-6779-5p" has a hairpin-like structure as its precursor, "hsa-mir -6779" (miRBase Accession No.MI0022624, sequence Number 441) is known.

[0243] As used herein, "hsa-miR-4271 gene" or "hsa-miR-4 The term "miR-4271" refers to the hsa-miR-4271 gene (miR-4271) set forth in SEQ ID NO: 164. RBase Accession No. MIMAT0016901) and other species The hsa-miR-4271 gene is a member of the Gof f According to the method described in LA et al., 2009, PLoS One, vol. 4, e7192. In addition, "hsa-miR-4271" can be obtained by using hairpin as a precursor. The miRBase Accession No. 1366666 has a sigma-like structure. No. MI0015879, SEQ ID NO: 442) is known.

[0244] As used herein, the term "hsa-miR-5195-3p gene" or "hsa-mi The term "miR-5195-3p" refers to hsa-miR-5195 as set forth in SEQ ID NO: 165. -3p gene (miRBase Accession No. MIMAT0021127 ) and other species homologs or orthologs. The 5-3p gene is described in Schotte D et al., 2011, Leukemia, vol. 25, p. The method can be obtained by the method described in 1389-1399. R-5195-3p is a precursor of hsa-mir-5, which has a hairpin-like structure. 195" (miRBase Accession No. MI0018174, SEQ ID NO: 443) is known.

[0245] As used herein, the term "hsa-miR-6762-5p gene" or "hsa-mi R-6762-5p" includes the hsa-miR-6762 -5p gene (miRBase Accession No. MIMAT0027424 ) described in SEQ ID NO: 166, as well as homologs or orthologs of other species. The hsa-miR-676 2-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-6762-5p" has a hairpin-like structure as its precursor, "hsa-mir -6762" (miRBase Accession No. MI0022607, sequence No. 444) is known.

[0246] As used herein, the term "hsa-miR-939-5p gene" or "hsa-miR -939-5p" includes the hsa-miR-939-5p gene (miRBase Accession No. MIMAT0004982) described in SEQ ID NO: 167, as well as homologs or orthologs of other species. The hsa-miR-939-5p gene can be obtained by the method described in Lui WO et al., 2007, Cancer Res, 67, p6031- 6043. Also, "hsa-miR-939 -5p" has a hairpin-like structure as its precursor, "hsa-mir-939" (mi RBase Accession No. MI0005761, SEQ ID NO: 445) is known .

[0247] As used herein, the term "hsa-miR-1247-3p gene" or "hsa-mi The term "R-1247-3p" includes the hsa-miR-1247 -3p gene (miRBase Accession No. MIMAT0022721 ), as well as homologs or orthologs of other species. The hsa-miR-124 7-3p gene can be obtained by the method described in Morin RD et al., 2008, Genome Res, 18, pp610-621. Also, "hsa-miR -1247-3p" has a hairpin-like structure as its precursor, "hsa-mir-12 47" (miRBase Accession No. MI0006382, SEQ ID NO: 4 46) is known.

[0248] As used herein, the term "hsa-miR-6777-5p gene" or "hsa-mi R-6777-5p" includes the hsa-miR-6777 -5p gene (miRBase Accession No. MIMAT0027454 ), as well as homologs or orthologs of other species. The hsa-miR-677 7-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp1634-1645. Also, "hsa- miR-6777-5p" has a hairpin-like structure as its precursor, "hsa-mir -6777" (miRBase Accession No. MI0022622, SEQ ID NO: 447) is known.

[0249] As used herein, the term "hsa-miR-6722-3p gene" or "hsa-mi R-6722-3p" includes the hsa-miR-6722 -3p gene (miRBase Accession No. MIMAT0025854 ) and homologs or orthologs of other species are included. hsa-miR-672 The 2-3p gene can be obtained by the method described in Li Y et al., 2012, Gene, Vol. 497, p330-335. Also, "hsa-miR-672 2-3p" has a hairpin-like structure as its precursor, "hsa-mir-672 2" (miRBa se Accession No. MI0022557, SEQ ID NO: 448) is known to exist.

[0250] As used herein, the term "hsa-miR-3656 gene" or "hsa-miR-3 656" refers to the hsa-miR-3656 gene described in SEQ ID NO: 171 (mi RBase Accession No. MIMAT0018076) and homologs or orthologs of other species. The hsa-miR-3656 gene can be obtained by the method described in Mei ri E et al., 2010, Nucleic Acids Res, Vol. 38, p6234- 6246. Also, "hsa-miR-365 6" has a hairpin-like structure as its precursor, "hsa-mir-3656" (miR Base Accession No. MI0016056, SEQ ID NO: 449) is known to exist.

[0251] As used herein, the term "hsa-miR-4688 gene" or "hsa-miR-4 688" refers to the hsa-miR-4688 gene described in SEQ ID NO: 172 (mi RBase Accession No. MIMAT0019777) and homologs or orthologs of other species. ​​Including paralogs or orthologs, etc. The hsa-miR-4688 gene is Per sson H et al., 2011, Cancer Res, Vol. 71, p78-86, and can be obtained by the method described therein. Also, "hsa-miR-4688" has a hairpin-like structure as its precursor, "hsa-mir-4688" (miRBase Accession No. MI0017321, SEQ ID NO: 450).

[0252] As used herein, the term "hsa-miR-3195 gene" or "hsa-miR-3 195" includes the hsa-miR-3195 gene (miRBase Accession No. MIMAT0015079) described in SEQ ID NO: 173 and other paralogs or orthologs of other species. The hsa-miR-3195 gene can be obtained by the method described in Stark MS et al., 2010, PLoS One, Vol. 5, e9685. Also, "hsa-miR-3195" has a hairpin-like structure as its precursor, "hsa-mir-3195" (miRBase Accession No. MI0014240, SEQ ID NO: 451).

[0253] As used herein, the term "hsa-miR-6766-5p gene" or "hsa-mi R-6766-5p" includes the hsa-miR-6766 -5p gene (miRBase Accession No. MIMAT0027432 ) and other paralogs or orthologs of other species. The hsa-miR-676 6-5p gene is described in Ladewig E et al., 2012, Genome Res, Vol. 22 ​​​​​​​​​, can be obtained by the method described in p1634 - 1645. Also, "hsa- miR-6766-5p" has a hairpin-like structure as its precursor, "hsa-mir -6766" (miRBase Accession No. MI0022611, sequence number 452) is known.

[0254] As used herein, the term "hsa-miR-4447 gene" or "hsa-miR-4 447" includes the hsa-miR-4447 gene described in SEQ ID NO: 175 (mi RBase Accession No. MIMAT0018966) and other orthologs or homologs of other species. The hsa-miR-4447 gene can be obtained by the method described by Jim a DD et al., 2010, Blood, Vol. 116, e118 - e127. Also, "hsa-miR-4447" has a hairpin-like structure as its precursor, "hsa-mir-4447" (miRBase Accessi on No. MI0016790, SEQ ID NO: 453) is known. "hsa-mir-4447" (miRBase Accessi on No. MI0016790, SEQ ID NO: 453) is known.

[0255] As used herein, the term "hsa-miR-4656 gene" or "hsa-miR-4 656" includes the hsa-miR-4656 gene described in SEQ ID NO: 176 (mi RBase Accession No. MIMAT0019723) and other orthologs or homologs of other species. The hsa-miR-4656 gene can be obtained by the method described by Per sson H et al., 2011, Cancer Res, Vol. 71, p78 - 86. Also, "hsa-miR-4656" has a hairpin-like structure as its precursor, described in Per sson H et al., 2011, Cancer Res, Vol. 71, p78 - 86. Also, "hsa-miR-4656" has a hairpin-like structure as its precursor, "hsa-mir-4656", which has a hairpin-like structure, is known (miRBase Accession No. MI0017284, SEQ ID NO: 454). sion No. MI0017284, SEQ ID NO: 454).

[0256] As used herein, the term "hsa-miR-7108-5p gene" or "hsa-mi R-7108-5p" includes the hsa-miR-7108-5p gene described in SEQ ID NO: 177 (miRBase Accession No. MIMAT0028113 ), as well as homologs or orthologs of other species. The hsa-miR-710 8-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22: p1634-1645. Also, "hsa-miR-7108-5p" has a hairpin-like structure as its precursor, "hsa-mir -7108" (miRBase Accession No. MI0022959, SEQ ID NO: 455) is known. -7108" (miRBase Accession No. MI0022959, SEQ ID NO: 455) is known.

[0257] As used herein, the term "hsa-miR-3191-3p gene" or "hsa-mi R-3191-3p" includes the hsa-miR-3191-3p gene described in SEQ ID NO: 178 (miRBase Accession No. MIMAT0015075 ), as well as homologs or orthologs of other species. The hsa-miR-319 1-3p gene can be obtained by the method described in Stark MS et al., 2010, PLoS One, 5:e96 85. Also, "hsa-miR-3191-3p" has a hairpin-like structure as its precursor, "hsa-mir-3191" (mi RBase Accession No. MI0015075 RBase Accession No. MI0015075 RBase Accession No. MI0014236, SEQ ID NO: 456) is known to be.

[0258] As used herein, the term "hsa-miR-1273g-3p gene" or "hsa-m iR-1273g-3p" includes the hsa-miR-12 73g-3p gene (miRBase Accession No. MIMAT0022 742) described in SEQ ID NO: 179, as well as homologs or orthologs of other species. The hsa-miR- 1273g-3p gene can be obtained by the method described in Reshmi G et al., 2011, Genomics, 97 vol., p333-340. Also, "hsa-m iR-1273g-3p" has a hairpin-like structure as its precursor, "hsa-mir -1273g" (miRBase Accession No. MI0018003, SEQ ID NO: 457) is known.

[0259] As used herein, the term "hsa-miR-4463 gene" or "hsa-miR-4 463" includes the hsa-miR-4463 gene (mi RBase Accession No. MIMAT0018987) described in SEQ ID NO: 180, as well as homologs or orthologs of other species. The hsa-miR-4463 gene can be obtained by the method described in Jim a DD et al., 2010, Blood, 116 vol., e118-e127. Also, "hsa-miR-4463" has a hairpin-like structure as its precursor, "hsa-mir-4463" (miRBase Accessi on No. MI0016811, SEQ ID NO: 458) is known. to be.

[0260] As used herein, the term "hsa-miR-2861 gene" or "hsa-miR-2 861" refers to the hsa-miR-2861 gene (mi RBase Accession No. MIMAT0013802) described in SEQ ID NO: 181, as well as homologs or orthologs of other species, etc. The hsa-miR-2861 gene can be obtained by the method described by Li H et al., 2009, J Clin Invest, Vol. 119, p3666-3677. Also, "hsa-miR-2861" refers to "hsa-mir-2861" (miRBase A ccession No. MI0013006, SEQ ID NO: 459), which forms a hairpin-like structure as its precursor. As used herein, the term "hsa-miR-3196 gene" or "hsa-miR-3 196" refers to the hsa-miR-3196 gene (mi RBase Accession No. MIMAT0015080) described in SEQ ID NO: 182, as well as homologs or orthologs of other species, etc. The hsa-miR-3196 gene can be obtained by the method described by Sta

[0261] rk MS et al., 2010, PLoS One, Vol. 5, e9685. Also, "hsa-miR-3196" refers to "hsa-mir-3196" (miRBase Accession No. MI0014241, SEQ ID NO: 460), which forms a hairpin-like structure as its precursor. As used herein, the term "hsa-miR-6877-5p gene" or "hsa-mi R-6877-5p" refers to hsa-miR-6877 described in SEQ ID NO: 183

[0262] ​​​​​​-5p gene (miRBase Accession No. MIMAT0027654 ) and other homologs or orthologs of other species are included. hsa-miR-687 The 7-5p gene can be obtained by the method described by Ladewig E et al., 2012, Genome Res, Vol. 22 , pp. 1634-1645. Also, "hsa- miR-6877-5p" has a hairpin-like structure as its precursor, "hsa-mir -6877" (miRBase Accession No. MI0022724, sequence No. 461) is known.

[0263] As used herein, the term "hsa-miR-3679-5p gene" or "hsa-mi R-3679-5p" includes the hsa-miR-3679 -5p gene (miRBase Accession No. MIMAT0018104 ) described in SEQ ID NO: 184 and other homologs or orthologs of other species. hsa-miR-36 The 79-5p gene can be obtained by the method described by Creighton CJ et al., 2010, PLoS One, Vol. 5 , e9637. Also, "hsa-miR- 3679-5p" has a hairpin-like structure as its precursor, "hsa-mir-367 9" (miRBase Accession No. MI0016080, SEQ ID NO: 46 2) is known.

[0264] As used herein, the term "hsa-miR-4442 gene" or "hsa-miR-4 442" includes the hsa-miR-4442 gene (mi RBase Accession No. MIMAT0018960) described in SEQ ID NO: 185 and other homologs of other species. It includes paralogs or orthologs, etc. The hsa-miR-4442 gene was described by Jim a DD et al. in 2010, Blood, Vol. 116, pp. e118 - e127 by the method described therein. Also, "hsa-miR-4442" has, as its precursor "hsa-mir-4442" which takes a hairpin-like structure (miRBase Accessi on No. MI0016785, SEQ ID NO: 463) is known.

[0265] As used herein, the term "hsa-miR-6789-5p gene" or "hsa-mi R-6789-5p" includes the hsa-miR-6789 -5p gene (miRBase Accession No. MIMAT0027478 ) described in SEQ ID NO: 186 and other species homologs or orthologs, etc. The hsa-miR-678 9-5p gene can be obtained by the method described by Ladewig E et al. in 2012, Genome Res, Vol. 22 , pp. 1634 - 1645. Also, "hsa- miR-6789-5p" has, as its precursor, "hsa-mir -6789" which takes a hairpin-like structure (miRBase Accession No. MI0022634, SEQ ID NO: 464) is known.

[0266] As used herein, the term "hsa-miR-6782-5p gene" or "hsa-mi R-6782-5p" includes the hsa-miR-6782 -5p gene (miRBase Accession No. MIMAT0027464 ) described in SEQ ID NO: 187 and other species homologs or orthologs, etc. The hsa-miR-678 The 2-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22. , p1634-1645. Also, "hsa- miR-6782-5p" has a hairpin-like structure as its precursor, "hsa-mir -6782" (miRBase Accession No. MI0022627, sequence No. 465) is known.

[0267] As used herein, the term "hsa-miR-486-3p gene" or "hsa-miR -486-3p" includes the hsa-miR-486-3p gene described in SEQ ID NO: 188 (miRBase Accession No. MIMAT0004762) and other homologs or orthologs of other species. The hsa-miR-486-3p gene can be obtained by the method described in Fu H et al., 2005, FEBS Lett, Vol. 579, p3849-38 54. Also, "hsa-miR-486-3 p" has a hairpin-like structure as its precursor, "hsa-mir-486, hsa-m ir-486-2" (miRBase Accession No. MI0002470 , MI0023622, SEQ ID NOs: 466, 467) is known.

[0268] As used herein, the term "hsa-miR-6085 gene" or "hsa-miR-6 085" includes the hsa-miR-6085 gene described in SEQ ID NO: 189 (mi RBase Accession No. MIMAT0023710) and other homologs or orthologs of other species. The hsa-miR-6085 gene is from Voe ​The method described by llenkle C et al. in 2012, RNA, Vol. 18, pp472 - 484 can be used to obtain it. Also, "hsa - miR - 6085" has a hairpin - like structure as its precursor, namely "hsa - mir - 6085" (miRBase Accession No. MI0020362, SEQ ID NO: 468) is known. The term "hsa - miR - 4746 - 3p gene" or "hsa - miR - 4746 - 3p" used in this specification includes the hsa - miR - 4746 - 3p gene (miRBase Accession No. MIMAT0019881 described in SEQ ID NO: 190), as well as homologs or orthologs of other species. The hsa - miR - 4746 - 3p gene can be obtained by the method described by Persson H et al. in 2011, Cancer Res, Vol. 71, pp78 - 86. Also, "hsa - miR - 4746 - 3p" has a hairpin - like structure as its precursor, namely "hsa - mir - 4746" (miRBase Accession No. MI0017385, SEQ ID NO: 469) is known.

[0269] The term "hsa - miR - 619 - 5p gene" or "hsa - miR - 619 - 5p" used in this specification includes the hsa - miR - 619 - 5p gene (miRBase Accession No. MIMAT0026622) described in SEQ ID NO: 191, as well as homologs or orthologs of other species. The hsa - miR - 619 - 5p gene can be obtained by the method described by Cummins JM et al. in 2006, Proc Natl Acad Sc described in SEQ ID NO: 190), as well as homologs or orthologs of other species. The hsa - miR - 4746 - 3p gene can be obtained by the method described by Persson H et al. in 2011, Cancer Res, Vol. 71, -3p gene (miRBase Accession No. MIMAT0019881 ) and so on. The hsa - miR - 4746 - 3p gene can be obtained by the method described by Persson H et al. in 2011, Cancer Res, 71 volumes , pp78 - 86. Also, "hsa - miR - 4746 - 3p" has a hairpin - like structure as its precursor, namely "hsa - mir - 4746" (miRBase Accession No. MI0017385, SEQ ID NO: 46 、p78 - 86. Also, "hsa - miR - 4746 - 3p" has a hairpin - like structure as its precursor, namely "hsa - mir - 474 6" (miRBase Accession No. MI0017385, SEQ ID NO: 46 9) is known.

[0270] The term "hsa - miR - 619 - 5p gene" or "hsa - miR -619 - 5p" used in this specification includes the hsa - miR - 619 - 5p gene (miRBase Accession No. MIMAT0026622) described in SEQ ID NO: 191 and so on. The hsa - miR - 619 - 5p gene can be obtained by the method described by Cummins JM et al. in 2006, Proc Natl Acad Sc and homologs or orthologs of other species. The hsa - miR - 619 - 5p gene can be obtained by the method described by Cummins JM et al. in 2006, Proc Natl Acad Sc , 2006, Proc Natl Acad Sc It can be obtained by the method described in i USA, Vol. 103, p3687 - 3692. Also, "hsa - miR - 619 - 5p" has a hairpin - like structure as its precursor "hsa - mir - 619" (miRBase Accession No. MI 0003633, SEQ ID NO: 470) is known.

[0271] As used herein, the term "hsa - miR - 937 - 5p gene" or "hsa - miR - 937 - 5p" includes the hsa - miR - 937 - 5p gene described in SEQ ID NO: 192 (miRBase Accession No. MIMAT0022938) and other homologs or orthologs of other species. The hsa - miR - 937 - 5p gene can be obtained by the method described in Lui WO et al., 2007, Cancer Res, Vol. 67, p6031 - 6043. Also, "hsa - miR - 937 - 5p" has a hairpin - like structure as its precursor "hsa - mir - 937" (mi RBase Accession No. MI0005759, SEQ ID NO: 471) is known .

[0272] As used herein, the term "hsa - miR - 6803 - 5p gene" or "hsa - mi R - 6803 - 5p" includes the hsa - miR - 6803 - 5p gene described in SEQ ID NO: 193 (miRBase Accession No. MIMAT0027506 ) and other homologs or orthologs of other species. The hsa - miR - 680 3 - 5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22 , p1634 - 1645. Also, "hsa - "miR-6803-5p" has a hairpin-like structure as its precursor, "hsa-mir" -6803" (miRBase Accession No. MI0022648, sequence number 472) is known.

[0273] As used herein, the term "hsa-miR-4298 gene" or "hsa-miR-4 298" refers to the hsa-miR-4298 gene described in SEQ ID NO: 194 (mi RBase Accession No. MIMAT0016852) and other orthologs or paralogs of other species. The hsa-miR-4298 gene can be obtained by the method described by Gof f LA et al., 2009, PLoS One, 4, e7192. Also, "hsa-miR-4298" has a hairpin -like structure as its precursor, "hsa-mir-4298" (miRBase Accession No. MI0015830, SEQ ID NO: 473) is known. No. MI0015830, SEQ ID NO: 473) is known.

[0274] As used herein, the term "hsa-miR-4454 gene" or "hsa-miR-4 454" refers to the hsa-miR-4454 gene described in SEQ ID NO: 195 (mi RBase Accession No. MIMAT0018976) and other orthologs or paralogs of other species. The hsa-miR-4454 gene can be obtained by the method described by Jim a DD et al., 2010, Blood, 116, e118 - e127. Also, "hsa-miR-4454" has a hairpin -like structure as its precursor, "hsa-mir-4454" (miRBase Accessi by the method described by Jim a DD et al., 2010, Blood, 116, e118 - e127. Also, "hsa-miR-4454" has a hairpin -like structure as its precursor, "hsa-mir-4454" (miRBase Accessi on No.MI0016800, Accession No. 474) is known.

[0275] As used herein, the term "hsa-miR-4459 gene" or "hsa-miR-4 459" includes the hsa-miR-4459 gene (mi RBase Accession No.MIMAT0018981) described in SEQ ID NO: 196 and other homologous or orthologous genes of other species. The hsa-miR-4459 gene can be obtained by the method described by Jim a DD et al., 2010, Blood, Vol. 116, e118-e127. Also, "hsa-miR-4459" has, as its precursor, "hsa-mir-4459" (miRBase Accessi on No.MI0016805, Accession No. 475) which takes a hairpin-like structure and is known.

[0276] As used herein, the term "hsa-miR-7150 gene" or "hsa-miR-7 150" includes the hsa-miR-7150 gene (mi RBase Accession No.MIMAT0028211) described in SEQ ID NO: 197 and other homologous or orthologous genes of other species. The hsa-miR-7150 gene can be obtained by the method described by Oul as A et al., 2009, Nucleic Acids Res, Vol. 37, p3276- 3287. Also, "hsa-miR-715 0" has, as its precursor, "hsa-mir-7150" (miR Base Accession No.MI0023610, Accession No. 476) which takes a hairpin-like structure and is known

[0277] ​​​​As used herein, the term "hsa-miR-6880-5p gene" or "hsa-mi R-6880-5p" includes the hsa-miR-6880 -5p gene (miRBase Accession No. MIMAT0027660 ) described in SEQ ID NO: 198, as well as homologs or orthologs of other species. The hsa-miR-688 0-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp. 1634-1645. Also, "hsa- miR-6880-5p" has a hairpin-like structure as its precursor, "hsa-mir -6880" (miRBase Accession No. MI0022727, sequence No. 477) is known.

[0278] As used herein, the term "hsa-miR-4449 gene" or "hsa-miR-4 449" includes the hsa-miR-4449 gene (mi RBase Accession No. MIMAT0018968) described in SEQ ID NO: 199, as well as homologs of other species or orthologs. The hsa-miR-4449 gene can be obtained by the method described in Jim a DD et al., 2010, Blood, 116, pp. e118-e127. Also, "hsa-miR-4449" has a hairpin-like structure as its precursor "hsa-mir-4449" (miRBase Accessi on No. MI0016792, SEQ ID NO: 478) is known.

[0279] As used herein, the term "hsa-miR-8063 gene" or "hsa-miR-8 The term "063" includes the hsa-miR-8063 gene (mi RBase Accession No. MIMAT0030990) described in SEQ ID NO: 200, as well as homologs or orthologs of other species. The hsa-miR-8063 gene can be obtained by the method described by Wan g HJ et al., 2013, Shock, Vol. 39, p480-487. Also, "hsa-miR-8063" has a hairpin-like structure as its precursor, "hsa-mir-8063" (miRBase Accession No. MI0025899, SEQ ID NO: 479) is known. The term "hsa-miR-4695-5p gene" or "hsa-mi R-4695-5p" used in this specification includes the hsa-miR-4695 -5p gene (miRBase Accession No. MIMAT0019788

[0280] described in SEQ ID NO: 201) and homologs or orthologs of other species. The hsa-miR-469 5-5p gene can be obtained by the method described by Persson H et al., 2011, Cancer Res, Vol. 71 , p78-86. Also, "hsa-miR- 4695-5p" has a hairpin-like structure as its precursor, "hsa-mir-469 5" (miRBase Accession No. MI0017328, SEQ ID NO: 48 0) is known. The term "hsa-miR-6132 gene" or "hsa-miR-6

[0281] 132" used in this specification includes the hsa-miR-6132 gene (mi described in SEQ ID NO: 202) RBase Accession No. (MIMAT0024616) and other homologs or orthologs of other species are included. The hsa-miR-6132 gene can be obtained by the method described by Dan emann M et al., 2012, Genome Biol Evol, Vol. 4, p552 -564. Also, "hsa-miR-613 2" has a hairpin-like structure as its precursor, "hsa-mir-6132" (miR Base Accession No. MI0021277, SEQ ID NO: 481) is known to exist.

[0282] As used herein, the term "hsa-miR-6829-5p gene" or "hsa-mi R-6829-5p" refers to the hsa-miR-6829 -5p gene described in SEQ ID NO: 203 (miRBase Accession No. MIMAT0027558 ) and other homologs or orthologs of other species. The hsa-miR-682 9-5p gene can be obtained by the method described by Ladewig E et al., 2012, Genome Res, Vol. 22 , p1634-1645. Also, "hsa- miR-6829-5p" has a hairpin-like structure as its precursor, "hsa-mir -6829" (miRBase Accession No. MI0022674, SEQ ID NO: 482) is known to exist.

[0283] As used herein, the term "hsa-miR-4486 gene" or "hsa-miR-4 486" refers to the hsa-miR-4486 gene described in SEQ ID NO: 204 (mi RBase Accession No. MIMAT0019020) and other homologs of other species ​includes morologs or orthologs, etc. The hsa-miR-4486 gene was described by Jim a DD et al. in 2010, Blood, Vol. 116, pp. e118 - e127 by the method described therein. Also, "hsa-miR-4486" has, as its precursor, "hsa-mir-4486" which takes a hairpin-like structure (miRBase Accessi on No. MI0016847, SEQ ID NO: 483) is known.

[0284] As used herein, the term "hsa-miR-6805-3p gene" or "hsa-mi R-6805-3p" includes the hsa-miR-6805-3p gene (miRBase Accession No. MIMAT0027511 ) described in SEQ ID NO: 205, as well as homologs or orthologs of other species, etc. The hsa-miR-680 5-3p gene can be obtained by the method described by Ladewig E et al. in 2012, Genome Res, Vol. 22 , pp. 1634 - 1645. Also, "hsa- miR-6805-3p" has, as its precursor, "hsa-mir -6805" which takes a hairpin-like structure (miRBase Accession No. MI0022650, SEQ ence No. 304) is known.

[0285] As used herein, the term "hsa-miR-6826-5p gene" or "hsa-mi R-6826-5p" includes the hsa-miR-6826-5p gene (miRBase Accession No. MIMAT0027552 ) described in SEQ ID NO: 206, as well as homologs or orthologs of other species, etc. The hsa-miR-682 ​​The 6-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22. , and can be obtained by the method described on pages 1634 - 1645. Also, "hsa- miR-6826-5p" has a hairpin-like structure as its precursor, "hsa-mir -6826" (miRBase Accession No. MI0022671, sequence No. 484) is known.

[0286] As used herein, the term "hsa-miR-4508 gene" or "hsa-miR-4 508" includes the hsa-miR-4508 gene described in SEQ ID NO: 207 (mi RBase Accession No. MIMAT0019045) and other homologs or orthologs of other species. The hsa-miR-4508 gene can be obtained by the method described in Jim a DD et al., 2010, Blood, Vol. 116, e118 - e127 . Also, "hsa-miR-4508" has a hairpin-like structure as its precursor, "hsa-mir-4508" (miRBase Accessi on No. MI0016872, SEQ ID NO: 485) is known. with a hairpin-like structure as its precursor, "hsa-mir-4508" (miRBase Accessi on No. MI0016872, SEQ ID NO: 485) is known.

[0287] As used herein, the term "hsa-miR-1343-5p gene" or "hsa-mi R-1343-5p" includes the hsa-miR-1343 -5p gene described in SEQ ID NO: 208 (miRBase Accession No. MIMAT0027038 ) and other homologs or orthologs of other species. The hsa-miR-134 3-5p gene is described in Persson H et al., 2011, Cancer Res, Vol. 71 , can be obtained by the method described in p78-86. Also, "hsa-miR- 1343-5p" has a hairpin-like structure as its precursor, "hsa-mir-134 3" (miRBase Accession No. MI0017320, SEQ ID NO: 36 1) is known.

[0288] As used herein, the term "hsa-miR-7114-5p gene" or "hsa-mi R-7114-5p" refers to the hsa-miR-7114 -5p gene described in SEQ ID NO: 209 (miRBase Accession No. MIMAT0028125 ), as well as other species homologs or orthologs, etc. The hsa-miR-711 4-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-7114-5p" has a hairpin-like structure as its precursor, "hsa-mir -7114" (miRBase Accession No. MI0022965, sequence No. 486) is known.

[0289] As used herein, the term "hsa-miR-3622a-5p gene" or "hsa-m iR-3622a-5p" refers to the hsa-miR-36 22a-5p gene described in SEQ ID NO: 210 (miRBase Accession No. MIMAT0018 003), as well as other species homologs or orthologs, etc. The hsa-miR- 3622a-5p gene can be obtained by the method described in Witten D et al., 2010, BMC Biol, 8 , p58. Also, "hsa-miR-362 "2a-5p" has a hairpin-like structure as its precursor, "hsa-mir-3622a" "(miRBase Accession No.MI0016013, SEQ ID NO: 487 ) is known."

[0290] As used herein, the term "hsa-miR-6765-5p gene" or "hsa-mi R-6765-5p" refers to the hsa-miR-6765 described in SEQ ID NO: 211 -5p gene (miRBase Accession No.MIMAT0027430 ) and includes other species homologs or orthologs, etc. hsa-miR-676 5-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-6765-5p" has a hairpin-like structure as its precursor, "hsa-mir -6765" (miRBase Accession No.MI0022610, sequence NO: 488) is known."

[0291] As used herein, the term "hsa-miR-7845-5p gene" or "hsa-mi R-7845-5p" refers to the hsa-miR-7845 described in SEQ ID NO: 212 -5p gene (miRBase Accession No.MIMAT0030420 ) and includes other species homologs or orthologs, etc. hsa-miR-784 5-5p gene can be obtained by the method described in Ple H et al., 2012, PLoS One, 7, e50746 . Also, "hsa-miR-7845-5p " has a hairpin-like structure as its precursor, "hsa-mir-7845" (miRB ase Accession No. MI0025515, sequence number 489) is known. There are.

[0292] As used herein, the term "hsa-miR-3960 gene" or "hsa-miR-3 The term "miR-3960" refers to the hsa-miR-3960 gene set forth in SEQ ID NO: 213 (mi RBase Accession No. MIMAT0019337) and other species The hsa-miR-3960 gene is a homologue or ortholog of the Hu R et al., 2011, J Biol Chem, vol. 286, p12328-12339 The hsa-miR-3960 can be obtained by the method described in the The precursor of "hsa-mir-3960" (miRBase A Accession No. MI0016964, SEQ ID NO: 490) is known.

[0293] As used herein, the term "hsa-miR-6749-5p gene" or "hsa-mi The term "miR-6749-5p" refers to hsa-miR-6749 as set forth in SEQ ID NO: 214. -5p gene (miRBase Accession No. MIMAT0027398 ) and other species homologs or orthologs. The 9-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 The hsa- miR-6749-5p is a precursor of the hairpin-like structure known as hsa-mir. -6749" (miRBase Accession No. MI0022594, sequence Number 491) is known.

[0294] As used herein, the term "hsa-miR-1260b gene" or "hsa-miR- 1260b" refers to the hsa-miR-1260b gene described in SEQ ID NO: 215 (miRBase Accession No. MIMAT0015041) and other homologous or orthologous genes of other species. The hsa-miR-1260b gene can be obtained by the method described in Stark MS et al., 2010, PLoS One, 5, e9685. Also, "hsa-miR-1260b" has a hairpin-like structure as its precursor, "hsa-mir-1260b" (miRBase Acc ession No. MI0014197, SEQ ID NO: 492).

[0295] As used herein, the term "hsa-miR-6799-5p gene" or "hsa-mi R-6799-5p" refers to the hsa-miR-6799-5p gene described in SEQ ID NO: 216 (miRBase Accession No. MIMAT0027498 ) and other homologous or orthologous genes of other species. The hsa-miR-6799-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645. Also, "hsa-miR-6799-5p" has a hairpin-like structure as its precursor, "hsa-mir-6799" (miRBase Accession No. MI0022644, sequence NO: 493).

[0296] As used herein, the term "hsa-miR-4723-5p gene" or "hsa-mi The term "R-4723-5p" includes the hsa-miR-4723 -5p gene (miRBase Accession No. MIMAT0019838 ), as well as homologs or orthologs of other species. The hsa-miR-472 3-5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71 , pp78-86. Also, "hsa-miR- 4723-5p" has a hairpin-like structure as its precursor, "hsa-mir-472 3" (miRBase Accession No. MI0017359, SEQ ID NO: 49 4) is known.

[0297] As used herein, the term "hsa-miR-6784-5p gene" or "hsa-mi R-6784-5p" includes the hsa-miR-6784 -5p gene (miRBase Accession No. MIMAT0027468 ), as well as homologs or orthologs of other species. The hsa-miR-678 4-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp1634-1645. Also, "hsa- miR-6784-5p" has a hairpin-like structure as its precursor, "hsa-mir -6784" (miRBase Accession No. MI0022629, SEQ ID NO: 495) is known.

[0298] As used herein, the term "hsa-miR-5100 gene" or "hsa-miR-5 100" includes the hsa-miR-5100 gene described in SEQ ID NO: 219 (mi RBase Accession No. (MIMAT0022259) and other homologous or orthologous genes of other species are included. The hsa-miR-5100 gene can be obtained by the method described by Tan don M et al., 2012, Oral Dis, Vol. 18, p127-131. Also, "hsa-miR-5100" has a precursor that forms a hairpin-like structure, namely "hsa-mir-5100" (miRBase Acces sion No. MI0019116, SEQ ID NO: 496).

[0299] As used herein, the term "hsa-miR-6769b-5p gene" or "hsa-m iR-6769b-5p" includes the hsa-miR-67 69b-5p gene described in SEQ ID NO: 220 (miRBase Accession No. MIMAT0027 620) and other homologous or orthologous genes of other species. The hsa-miR- 6769b-5p gene can be obtained by the method described by Ladewig E et al., 2012, Genome Res ., Vol. 22, p1634-1645. Also, " hsa-miR-6769b-5p" has a precursor that forms a hairpin-like structure, namely "hs a-mir-6769b" (miRBase Accession No. MI0022 706, SEQ ID NO: 497).

[0300] As used herein, the term "hsa-miR-1207-5p gene" or "hsa-mi R-1207-5p" includes the hsa-miR-1207 -5p gene described in SEQ ID NO: 221 (miRBase Accession No. MIMAT0005871 ​​) and other species homologs or orthologs, etc. are included. hsa-miR-120 The 7-5p gene can be obtained by the method described in Huppi K et al., 2008, Mol Cancer Res, 6 Volume, p212-221. Also, "hsa-m iR-1207-5p" takes a hairpin-like structure as its precursor, "hsa-mir- 1207" (miRBase Accession No. MI0006340, sequence number 498) is known.

[0301] As used herein, the term "hsa-miR-642a-3p gene" or "hsa-mi R-642a-3p" refers to the hsa-miR-642a described in SEQ ID NO: 222 -3p gene (miRBase Accession No. MIMAT0020924 ) and other species homologs or orthologs, etc. are included. hsa-miR-642 The a-3p gene can be obtained by the method described in Cummins JM et al., 2006, Proc Natl Aca d Sci U S A, 103, p3687-3692. Also, "hsa-miR-642a-3p" takes a hairpin structure as its precursor, "hsa-mir-642a" (miRBase Accession No. MI0003657, sequence number 499) is known. No.MI0003657, sequence number 499) is known.

[0302] As used herein, the term "hsa-miR-4505 gene" or "hsa-miR-4 505" refers to the hsa-miR-4505 gene described in SEQ ID NO: 223 (mi RBase Accession No. MIMAT0019041) and other species homologs Includes homologs or orthologs, etc. The hsa-miR-4505 gene was described by Jim a DD et al., in 2010, Blood, Vol. 116, pp. e118 - e127 by the method described therein. Also, "hsa-miR-4505" has, as its precursor "hsa-mir-4505" which takes a hairpin-like structure (miRBase Accessi on No. MI0016868, SEQ ID NO: 500) is known.

[0303] As used herein, the term "hsa-miR-4270 gene" or "hsa-miR-4 270" includes the hsa-miR-4270 gene (mi RBase Accession No. MIMAT0016900) described in SEQ ID NO: 224 and other species homologs or orthologs, etc. The hsa-miR-4270 gene can be obtained by the method described by Gof f LA et al., in 2009, PLoS One, Vol. 4, e7192. Also, "hsa-miR-4270" has, as its precursor, a hairpin -like structure "hsa-mir-4270" (miRBase Accession No. MI0015878, SEQ ID NO: 501) is known. No. MI0015878, SEQ ID NO: 501) is known.

[0304] As used herein, the term "hsa-miR-6721-5p gene" or "hsa-mi R-6721-5p" includes the hsa-miR-6721 -5p gene (miRBase Accession No. MIMAT0025852 ) described in SEQ ID NO: 225 and other species homologs or orthologs, etc. The hsa-miR-672 1-5p gene was described by Li Y et al., in 2012, Gene, Vol. 497, pp. 330 - 335 can be obtained by the methods described. Also, "hsa-miR-6721-5p" has a hairpin-like structure as its precursor, "hsa-mir-6721" (miRBa se Accession No. MI0022556, SEQ ID NO: 502) is known .

[0305] As used herein, the term "hsa-miR-7111-5p gene" or "hsa-mi R-7111-5p" refers to the hsa-miR-7111 -5p gene (miRBase Accession No. MIMAT0028119 ) described in SEQ ID NO: 226, as well as homologs or orthologs of other species, etc. The hsa-miR-711 1-5p gene can be obtained by the methods described by Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-7111-5p" has a hairpin-like structure as its precursor, "hsa-mir -7111" (miRBase Accession No. MI0022962, sequence No. 503) is known.

[0306] As used herein, the term "hsa-miR-6791-5p gene" or "hsa-mi R-6791-5p" refers to the hsa-miR-6791 -5p gene (miRBase Accession No. MIMAT0027482 ) described in SEQ ID NO: 227, as well as homologs or orthologs of other species, etc. The hsa-miR-679 1-5p gene can be obtained by the methods described by Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- "miR-6791-5p" has a hairpin-like structure as its precursor, "hsa-mir" -6791" (miRBase Accession No. MI0022636, sequence No. 504) is known.

[0307] As used herein, the term "hsa-miR-7109-5p gene" or "hsa-mi R-7109-5p" includes the hsa-miR-7109-5p gene described in SEQ ID NO: 228 (miRBase Accession No. MIMAT0028115 ), as well as homologs or orthologs of other species. The hsa-miR-710 9-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-7109-5p" has a hairpin-like structure as its precursor, "hsa-mir -7109" (miRBase Accession No. MI0022960, sequence No. 505) is known.

[0308] As used herein, the term "hsa-miR-4258 gene" or "hsa-miR-4 258" includes the hsa-miR-4258 gene described in SEQ ID NO: 229 (mi RBase Accession No. MIMAT0016879) and homologs or orthologs of other species. The hsa-miR-4258 gene can be obtained by the method described in Gof f LA et al., 2009, PLoS One, 4, e7192. Also, "hsa-miR-4258" has a hairpin -like structure as its precursor, "hsa-mir-4258" (miRBase Accession No. MI0016879).​​ No. MI0015857, SEQ ID NO: 506) is known.

[0309] As used herein, the term "hsa-miR-6515-3p gene" or "hsa-mi R-6515-3p" includes the hsa-miR-6515 -3p gene (miRBase Accession No. MIMAT0025487 ) described in SEQ ID NO: 230, as well as homologs or orthologs of other species. The hsa-miR-651 5-3p gene can be obtained by the method described in Joyce CE et al., 2011, Hum Mol Genet, 2 0, p4025-4040. Also, "hs a-miR-6515-3p" has a hairpin-like structure as its precursor, "hsa-m ir-6515" (miRBase Accession No. MI0022227, SEQ ID NO: 507) is known.

[0310] As used herein, the term "hsa-miR-6851-5p gene" or "hsa-mi R-6851-5p" includes the hsa-miR-6851 -5p gene (miRBase Accession No. MIMAT0027602 ) described in SEQ ID NO: 231, as well as homologs or orthologs of other species. The hsa-miR-685 1-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-6851-5p" has a hairpin-like structure as its precursor, "hsa-mir -6851" (miRBase Accession No. MI0022697, SEQ ID NO: 508) is known.

[0311] As used herein, the term "hsa-miR-6125 gene" or "hsa-miR-6 125" refers to the hsa-miR-6125 gene (mi RBase Accession No. MIMAT0024598) described in SEQ ID NO: 232, as well as homologs or orthologs of other species. The hsa-miR-6125 gene can be obtained by the method described in Smi th JL et al., 2012, J Virol, 86, p5278-5287. Also, "hsa-miR-6125" has a hairpin-like structure as its precursor, "hsa-mir-6125" (miRBase Acce ssion No. MI0021259, SEQ ID NO: 509).

[0312] As used herein, the term "hsa-miR-4749-5p gene" or "hsa-mi R-4749-5p" refers to the hsa-miR-4749 -5p gene (miRBase Accession No. MIMAT0019885 ) described in SEQ ID NO: 233, as well as homologs or orthologs of other species. The hsa-miR-474 9-5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71 , p78-86. Also, "hsa-miR- 4749-5p" has a hairpin-like structure as its precursor, "hsa-mir-474 9" (miRBase Accession No. MI0017388, SEQ ID NO: 51 0).

[0313] As used herein, the term "hsa-miR-4726-5p gene" or "hsa-mi The term "R-4726-5p" includes the hsa-miR-4726 gene described in SEQ ID NO: 234 -5p gene (miRBase Accession No. MIMAT0019845 ), as well as homologs or orthologs of other species. The hsa-miR-472 6-5p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71 , pp. 78-86. Also, "hsa-miR- 4726-5p" has a hairpin-like structure as its precursor, "hsa-mir-472 6" (miRBase Accession No. MI0017363, SEQ ID NO: 51 1) is known.

[0314] As used herein, the term "hsa-miR-4513 gene" or "hsa-miR-4 513" includes the hsa-miR-4513 gene described in SEQ ID NO: 235 (mi RBase Accession No. MIMAT0019050) and homologs or orthologs of other species. The hsa-miR-4513 gene can be obtained by the method described in Jim a DD et al., 2010, Blood, 116, e118-e127. Also, "hsa-miR-4513" has a hairpin-like structure as its precursor, "hsa-mir-4513" (miRBase Accessi on No. MI0016879, SEQ ID NO: 512) is known.

[0315] As used herein, the term "hsa-miR-760 gene" or "hsa-miR-76 0" includes the hsa-miR-760 gene described in SEQ ID NO: 236 (miRBa se Accession No.MIMAT0004957) and other species homologs or orthologs, etc. The hsa-miR-760 gene was described by Berezik ov E et al., 2006, Genome Res, Vol. 16, p1289-1298 and can be obtained by the method described therein. Also, "hsa-miR-760" has a hairpin-like structure as its precursor "hsa-mir-760" (miRBase Acce ssion No.MI0005567, SEQ ID NO: 513) is known.

[0316] As used herein, the term "hsa-miR-602 gene" or "hsa-miR-60 2" includes the hsa-miR-602 gene described in SEQ ID NO: 237 (miRBa se Accession No.MIMAT0003270) and other species homologs or orthologs, etc. The hsa-miR-602 gene was described by Cummins JM et al., 2006, Proc Natl Acad Sci U S A, Vol. 103 , p3687-3692 and can be obtained by the method described therein. Also, "hsa- miR-602" has a hairpin-like structure as its precursor "hsa-mir-602 " (miRBase Accession No.MI0003615, SEQ ID NO: 514 ).

[0317] As used herein, the term "hsa-miR-423-5p gene" or "hsa-miR -423-5p" includes the hsa-miR-423-5p gene described in SEQ ID NO: 238 (miRBase Accession No.MIMAT0004748) and so also includes other species homologs or orthologs, etc. hsa-miR-423-5p The gene was obtained by the method described in Kasashima K et al., 2004, Biochem Biophys Res Commun, 322, p403-410. Moreover, "hsa-miR-423-5p" has a hairpin-like structure as its precursor, "hsa-mir-423" (miRBase Accession No.M I0001445, SEQ ID NO: 515) is known.

[0318] As used herein, the term "hsa-miR-92a-2-5p gene" or "hsa-m iR-92a-2-5p" includes the hsa-miR-92 a-2-5p gene (miRBase Accession No.MIMAT0004 508) described in SEQ ID NO: 239 and other species homologs or orthologs, etc. hsa-miR- The 92a-2-5p gene can be obtained by the method described in Mourelatos Z et al., 2002, Genes D ev, 16, p720-728. Also, " hsa-miR-92a-2-5p" has a hairpin-like structure as its precursor, "hs a-mir-92a-2" (miRBase Accession No.MI0000 094, SEQ ID NO: 516) is known.

[0319] As used herein, the term "hsa-miR-16-5p gene" or "hsa-miR- 16-5p" includes the hsa-miR-16-5p gene described in SEQ ID NO: 240 (miRBase Accession No.MIMAT0000069) and other living Includes species homologs or orthologs, etc. The hsa-miR-16-5p gene is 、Lagos-Quintana M et al., 2001, Science, Vol. 294, p8 Can be obtained by the method described in 53-858. Also, "hsa-miR-1 6-5p" has a hairpin-like structure as its precursor, "hsa-mir-16-1, h sa-mir-16-2" (miRBase Accession No. MI0000 070, MI0000115, SEQ ID NO: 517, 518) is known.

[0320] As used herein, the term "hsa-miR-451a gene" or "hsa-miR-4 51a" refers to the hsa-miR-451a gene described in SEQ ID NO: 241 (mi RBase Accession No. MIMAT0001631) and other species homologs or orthologs, etc. The hsa-miR-451a gene is Alt uvia Y et al., 2005, Nucleic Acids Res, Vol. 33, p269 7-2706 can be obtained by the method described. Also, "hsa-miR-4 51a" has a hairpin-like structure as its precursor, "hsa-mir-451a" (m iRBase Accession No. MI0001729, SEQ ID NO: 519) is known .

[0321] As used herein, the term "hsa-miR-135a-3p gene" or "hsa-mi R-135a-3p" refers to the hsa-miR-135a -3p gene described in SEQ ID NO: 242 (miRBase Accession No. MIMAT0004595 ) and other species homologs or orthologs, etc. are included. hsa-miR-135 The a-3p gene can be obtained by the method described in Lagos-Quintana M et al., 2002, Curr Bi ol, 12, p735-739. Also, " hsa-miR-135a-3p" takes a hairpin-like structure as its precursor, "hsa -mir-135a" (miRBase Accession No. MI000045 2, SEQ ID NO: 520) is known.

[0322] As used herein, the term "hsa-miR-486-5p gene" or "hsa-miR -486-5p" refers to the hsa-miR-486-5p gene (miRBase Accession No. MIMAT0002177) described in SEQ ID NO: 243 and other species homologs or orthologs, etc. hsa-miR-486-5p gene can be obtained by the method described in Fu H et al., 2005, FEBS Lett, 579, p3849-38 54. Also, "hsa-miR-486-5 p" takes a hairpin-like structure as its precursor, "hsa-mir-486, hsa-m ir-486-2" (miRBase Accession No. MI0002470 , MI0023622, SEQ ID NO: 466, 467) is known.

[0323] As used herein, the term "hsa-miR-4257 gene" or "hsa-miR-4 257" refers to the hsa-miR-4257 gene described in SEQ ID NO: 244 (mi RBase Accession No. MIMAT0016878) and other species homologs It includes homologs or orthologs such as morologs. The hsa-miR-4257 gene has a gain of function (Gof). It can be obtained by the method described by LA et al. in PLoS One, Vol. 4, e7192 in 2009. Also, "hsa-miR-4257" has a precursor "hsa-mir-4257" that forms a hairpin-like structure (miRBase Accession No. MI0015856, SEQ ID NO: 521).

[0324] As used herein, the term "hsa-miR-92b-5p gene" or "hsa-miR -92b-5p" includes the hsa-miR-92b-5p gene described in SEQ ID NO: 245 (miRBase Accession No. MIMAT0004792) and other homologs or orthologs of other species. The hsa-miR-92b-5p gene can be obtained by the method described by Cummins JM et al. in Proc Natl Acad Sci U S A, Vol. 103, pp. 3687-3692 in 2006. Also, "hsa-miR-92b-5p" has a precursor "hsa-mir-92b" that forms a hairpin-like structure (miRBase Accession No. MI 0003560, SEQ ID NO: 522).

[0325] As used herein, the term "hsa-miR-1915-3p gene" or "hsa-mi R-1915-3p" includes the hsa-miR-1915 -3p gene described in SEQ ID NO: 246 (miRBase Accession No. MIMAT0007892 ) and other homologs or orthologs of other species. hsa-miR-191 ​​The 5-3p gene can be obtained by the method described in Bar M et al., 2008, Stem Cells, 26, p24 96-2505. Also, "hsa-miR- 1915-3p" has a hairpin-like structure as its precursor, "hsa-mir-191 5" (miRBase Accession No. MI0008336, SEQ ID NO: 33 9) is known.

[0326] As used herein, the term "hsa-miR-718 gene" or "hsa-miR-71 8" refers to the hsa-miR-718 gene described in SEQ ID NO: 247 (miRBa se Accession No. MIMAT0012735) and other species homologs or orthologs, etc. The hsa-miR-718 gene can be obtained by the method described in Artzi S et al., 2008, BMC Bioinformatics, 9, p39. Also, "hsa-miR-718" has a hairpin-like structure as its precursor "hsa-mir-718" (miRBase Accessio n No. MI0012489, SEQ ID NO: 523) is known.

[0327] As used herein, the term "hsa-miR-940 gene" or "hsa-miR-94 0" refers to the hsa-miR-940 gene described in SEQ ID NO: 248 (miRBa se Accession No. MIMAT0004983) and other species homologs or orthologs, etc. The hsa-miR-940 gene can be obtained by the method described in Lui WO et al , 2007, Cancer Res, 67, p6031-6043. can be obtained by. Also, "hsa-miR-940" has a hairpin-like structure as its precursor, "hsa-mir-940" (miRBase Accession No. MI0005762, SEQ ID NO: 524) is known.

[0328] As used herein, the term "hsa-miR-296-5p gene" or "hsa-miR -296-5p" includes the hsa-miR-296-5p gene (miRBase Accession No. MIMAT0000690) described in SEQ ID NO: 249, and other homologs or orthologs of other species. The hsa-miR-296-5p gene can be obtained by the method described in Houbaviy HB et al., 2003, Dev Cell, Vol. 5, p351 -358. Also, "hsa-miR-296 -5p" has a hairpin-like structure as its precursor, "hsa-mir-296" (mi RBase Accession No. MI0000747, SEQ ID NO: 409) is known.

[0329] As used herein, the term "hsa-miR-23b-3p gene" or "hsa-miR -23b-3p" includes the hsa-miR-23b-3p gene (miRBase Accession No. MIMAT0000418) described in SEQ ID NO: 250, and other homologs or orthologs of other species. The hsa-miR-23b-3p gene can be obtained by the method described in Lagos-Quintana M et al., 2002, Curr Biol, 1 2, p735-739. Also, "hsa- miR-23b-3p" has a hairpin-like structure as its precursor, "hsa-mir- 23b" "23b" (miRBase Accession No. MI0000439, SEQ ID NO: 525) is known.

[0330] As used herein, the term "hsa-miR-92a-3p gene" or "hsa-miR -92a-3p" refers to the hsa-miR-92a-3p gene described in SEQ ID NO: 251 (miRBase Accession No. MIMAT0000092) and other homologs or orthologs of other species, etc. The hsa-miR-92a-3p gene can be obtained by the method described in Mourelatos Z et al., 2002, Genes Dev, 16, p 720-728. Also, "hsa-miR- 92a-3p" has a hairpin-like structure as its precursor, "hsa-mir-92a- 1, hsa-mir-92a-2" (miRBase Accession No. MI 0000093, MI0000094, SEQ ID NO: 526, 527) is known. 0000093, MI0000094, SEQ ID NO: 526, 527) is known.

[0331] As used herein, the term "hsa-miR-658 gene" or "hsa-miR-65 8" refers to the hsa-miR-658 gene described in SEQ ID NO: 252 (miRBa se Accession No. MIMAT0003336) and other homologs or orthologs of other species, etc. The hsa-miR-658 gene can be obtained by the method described in Cummins JM et al., 2006, Proc Natl Acad Sci U S A, 103 ., p3687-3692. Also, "hsa- miR-658" has a hairpin-like structure as its precursor, "hsa-mir-658 」(miRBase Accession No.MI0003682, SEQ ID NO: 528 ) is known.

[0332] As used herein, the term "hsa-miR-6842-5p gene" or "hsa-mi R-6842-5p" refers to the hsa-miR-6842 -5p gene described in SEQ ID NO: 253 (miRBase Accession No.MIMAT0027586 ) and includes other species homologs or orthologs, etc. The hsa-miR-684 2-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , p1634-1645. Also, "hsa- miR-6842-5p" has a hairpin-like structure as its precursor, "hsa-mir -6842" (miRBase Accession No.MI0022688, sequence No. 529) is known.

[0333] As used herein, the term "hsa-miR-6124 gene" or "hsa-miR-6 124" refers to the hsa-miR-6124 gene described in SEQ ID NO: 254 (mi RBase Accession No.MIMAT0024597) and includes other species ho mologs or orthologs, etc. The hsa-miR-6124 gene can be obtained by the method described in Smy th JL et al., 2012, J Virol, 86, p5278-5287 . Also, "hsa-miR-6124" has a hairpin-like structure as its precursor , "hsa-mir-6124" (miRBase Acce ssion No.MI0021258, SEQ ID NO: 530) is known.

[0334] As used herein, the term "hsa-miR-6765-3p gene" or "hsa-mi R-6765-3p" includes the hsa-miR-6765 -3p gene (miRBase Accession No. MIMAT0027431 ) described in SEQ ID NO: 255, as well as homologs or orthologs of other species. The hsa-miR-676 5-3p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp. 1634-1645. Also, "hsa- miR-6765-3p" has a hairpin-like structure as its precursor, "hsa-mir -6765" (miRBase Accession No. MI0022610, sequence No. 531) is known.

[0335] As used herein, the term "hsa-miR-7106-5p gene" or "hsa-mi R-7106-5p" includes the hsa-miR-7106 -5p gene (miRBase Accession No. MIMAT0028109 ) described in SEQ ID NO: 256, as well as homologs or orthologs of other species. The hsa-miR-710 6-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 , pp. 1634-1645. Also, "hsa- miR-7106-5p" has a hairpin-like structure as its precursor, "hsa-mir -7106" (miRBase Accession No. MI0022957, sequence No. 532) is known.

[0336] As used herein, the term "hsa-miR-4534 gene" or "hsa-miR-4 534" includes the hsa-miR-4534 gene (mi RBase Accession No. MIMAT0019073) described in SEQ ID NO: 257, and other homologs or orthologs of other species. The hsa-miR-4534 gene can be obtained by the method described in Jim a DD et al., 2010, Blood, Vol. 116, pp. e118-e127. Also, "hsa-miR-4534" has a hairpin-like structure as its precursor, "hsa-mir-4534" (miRBase Accessi on No. MI0016901, SEQ ID NO: 533).

[0337] As used herein, the term "hsa-miR-92b-3p gene" or "hsa-miR -92b-3p" includes the hsa-miR-92b-3p gene (miRBase Accession No. MIMAT0003218) described in SEQ ID NO: 258, and other homologs or orthologs of other species. The hsa-miR-92b-3p gene can be obtained by the method described in Cummins JM et al., 2006, Proc Natl Acad Sc i USA, Vol. 103, pp. 3687-3692. Also, "hsa-miR-92b-3p" has a hairpin-like structure as its precursor, "hsa-mir-92b" (miRBase Accession No. MI 0003560, SEQ ID NO: 522).

[0338] As used herein, the term "hsa-miR-3135b gene" or "hsa-miR- The term "3135b" includes the hsa-miR-3135b gene described in SEQ ID NO: 259 (miRBase Accession No. MIMAT0018985) and other homologous or orthologous genes of other species. The hsa-miR-3135b gene can be obtained by the method described in Jima DD et al., 2010, Blood, 116, e118-e127. Also, "hsa-miR-3135b" is known as "hsa-mir-3135b" (miRBase Accession No. MI0016809, SEQ ID NO: 534) which has a hairpin-like structure as its precursor.

[0339] As used herein, the term "hsa-miR-4687-3p gene" or "hsa-miR-4687-3p" includes the hsa-miR-4687-3p gene described in SEQ ID NO: 260 (miRBase Accession No. MIMAT0019775 ) and other homologous or orthologous genes of other species. The hsa-miR-4687-3p gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71, p78-86. Also, "hsa-miR-4687-3p" is known as "hsa-mir-4687" (miRBase Accession No. MI0017319, SEQ ID NO: 535) which has a hairpin-like structure as its precursor.

[0340] As used herein, the term "hsa-miR-762 gene" or "hsa-miR-762" includes the hsa-miR-762 gene described in SEQ ID NO: 261 (miRBa se Accession No... se Accession No.MIMAT0010313) and other species homologs or orthologs, etc. are included. The hsa-miR-762 gene was described by Berezik ov E et al., 2006, Genome Res, Vol. 16, p1289-1298 and can be obtained by the method described therein. Also, "hsa-miR-762" has a hairpin-like structure as its precursor "hsa-mir-762" (miRBase Accession No.MI0003892, SEQ ID NO: 536) is known.

[0341] As used herein, the term "hsa-miR-3619-3p gene" or "hsa-mi R-3619-3p" includes the hsa-miR-3619-3p gene described in SEQ ID NO: 262 (miRBase Accession No.MIMAT0019219 ) and other species homologs or orthologs, etc. The hsa-miR-361 9-3p gene can be obtained by the method described by Witten D et al., 2010, BMC Biol, Vol. 8, p58 and can be obtained by the method described therein. Also, "hsa-miR-3619-3p " has a hairpin-like structure as its precursor "hsa-mir-3619" (miRB ase Accession No.MI0016009, SEQ ID NO: 537) is known .

[0342] As used herein, the term "hsa-miR-4467 gene" or "hsa-miR-4 467" includes the hsa-miR-4467 gene described in SEQ ID NO: 263 (mi RBase Accession No.MIMAT0018994) and other species homologs Includes morologs or orthologs, etc. The hsa-miR-4467 gene was described by Jim a DD et al., in 2010, Blood, Volume 116, pp. e118 - e127 by the method described. Also, "hsa-miR-4467" has, as its precursor "hsa-mir-4467" which takes a hairpin-like structure (miRBase Accessi on No. MI0016818, SEQ ID NO: 538) is known.

[0343] As used herein, the term "hsa-miR-557 gene" or "hsa-miR-55 7" includes the hsa-miR-557 gene (miRBase Accession No. MIMAT0003221) described in SEQ ID NO: 264 and other species homologs or orthologs, etc. The hsa-miR-557 gene can be obtained by the method described by Cummins JM et al., in 2006, Proc Natl Acad Sci U S A, Volume 103 pp. 3687 - 3692. Also, "hsa- miR-557" has, as its precursor, "hsa-mir-557" which takes a hairpin-like structure (miRBase Accession No. MI0003563, SEQ ID NO: 539 ) is known.

[0344] As used herein, the term "hsa-miR-1237-5p gene" or "hsa-mi R-1237-5p" includes the hsa-miR-1237 -5p gene (miRBase Accession No. MIMAT0022946 ) described in SEQ ID NO: 265 and other species homologs or orthologs, etc. hsa-miR-123 The 7-5p gene can be obtained by the method described in Berezikov E et al., 2007, Mol Cell, Vol. 28, pp. 328-336. Also, "hsa-mi R-1237-5p" has a hairpin-like structure as its precursor, "hsa-mir-1 237" (miRBase Accession No. MI0006327, SEQ ID NO: 540) is known. 540) is known.

[0345] As used herein, the term "hsa-miR-1908-5p gene" or "hsa-mi R-1908-5p" refers to the hsa-miR-1908 -5p gene described in SEQ ID NO: 266 (miRBase Accession No. MIMAT0007881 ) and other homologs or orthologs of other species. The hsa-miR-190 8-5p gene can be obtained by the method described in Bar M et al., 2008, Stem Cells, Vol. 26, pp. 24 96-2505. Also, "hsa-miR- 1908-5p" has a hairpin-like structure as its precursor, "hsa-mir-190 8" (miRBase Accession No. MI0008329, SEQ ID NO: 54 1) is known.

[0346] As used herein, the term "hsa-miR-4286 gene" or "hsa-miR-4 286" refers to the hsa-miR-4286 gene described in SEQ ID NO: 267 (mi RBase Accession No. MIMAT0016916) and other homologs or orthologs of other species. The hsa-miR-4286 gene is described by Gof f LA et al., 2009, PLoS One, Vol. 4, e7192, by the method described therein. can be obtained. Also, "hsa-miR-4286" has a hairpin-like structure as its precursor, "hsa-mir-4286" (miRBase Accession No.MI0015894, SEQ ID NO: 542) is known. No.MI0015894, SEQ ID NO: 542) is known.

[0347] As used herein, the term "hsa-miR-6885-5p gene" or "hsa-mi R-6885-5p" includes the hsa-miR-6885-5p gene (miRBase Accession No.MIMAT0027670 SEQ ID NO: 268) described in SEQ ID NO: 268 and other species homologs or orthologs. hsa-miR-688 ) and other species homologs or orthologs. The hsa-miR-6885-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 volumes, p1634-1645. Also, "hsa- miR-6885-5p" has a hairpin-like structure as its precursor, "hsa-mir -6885" (miRBase Accession No.MI0022732, sequence SEQ ID NO: 543) is known. SEQ ID NO: 543) is known.

[0348] As used herein, the term "hsa-miR-6763-5p gene" or "hsa-mi R-6763-5p" includes the hsa-miR-6763-5p gene (miRBase Accession No.MIMAT0027426 SEQ ID NO: 269) described in SEQ ID NO: 269 and other species homologs or orthologs. The hsa-miR-676 ) and other species homologs or orthologs. The hsa-miR-6763-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 volumes, p1634-1645. Also, "hsa- miR-6763-5p" "miR-6763-5p" has a hairpin-like structure as its precursor, "hsa-mir" -6763" (miRBase Accession No. MI0022608, sequence number 544) is known.

[0349] As used herein, the term "hsa-miR-6089 gene" or "hsa-miR-6 089" includes the hsa-miR-6089 gene described in SEQ ID NO: 851 (mi RBase Accession No. MIMAT0023714) and other homologs or orthologs of other species. The hsa-miR-6089 gene can be obtained by the method described by Yo o JK et al., 2012, Stem Cells Dev, 21, p2049-205 7. Also, "hsa-miR-6089" has "hsa-mir-6089-1, hsa-m ir-6089-2" which has a hairpin-like structure as its precursor (miRBase Accession No. MI002036 6, MI0023563, SEQ ID NOs: 857, 858) are known.

[0350] As used herein, the term "hsa-miR-6816-5p gene" or "hsa-mi R-6816-5p" includes the hsa-miR-6816 -5p gene described in SEQ ID NO: 852 (miRBase Accession No. MIMAT0027532 ). The hsa-miR-68 16-5p gene can be obtained by the method described by Ladewig E et al., 2012, Genome Res., 2 2, p1634-1645. Also, "hs "a-miR-6816-5p" has a hairpin-like structure as its precursor, "hsa-m" "ir-6816" (miRBase Accession No. MI0022661, SEQ ID NO: 859) is known.

[0351] As used herein, the term "hsa-miR-4466 gene" or "hsa-miR-4 466" refers to the hsa-miR-4466 gene described in SEQ ID NO: 853 (mi RBase Accession No. MIMAT0018993) and other orthologs or paralogs of other species are included. The hsa-miR-4466 gene can be obtained by the method described by Ji ma DD et al., 2010, Blood, Vol. 116, pp. e118-e127. Also, "hsa-miR-4466" has a hairpin-like structure as its precursor "hsa-mir-4466" (miRBase Access ion No. MI0016817, SEQ ID NO: 860) is known. As used herein, the term "hsa-miR-4488 gene" or "hsa-miR-4 488" refers to the hsa-miR-4488 gene described in SEQ ID NO: 854 (mi

[0352] RBase Accession No. MIMAT0019022) and other orthologs or paralogs of other species are included. The hsa-miR-4488 gene can be obtained by the method described by Ji ma DD et al., 2010, Blood, Vol. 116, pp. e118-e127. Also, "hsa-miR-4488" has a hairpin-like structure as its precursor "hsa-mir-4488" (miRBase Access ion No. MI0019022) is known. ma DD et al., 2010, Blood, Vol. 116, pp. e118-e127. Also, "hsa-miR-4488" has a hairpin-like structure as its precursor "hsa-mir-4488" (miRBase Access ion No. MI0019022) is known. Ion No. MI0016849, SEQ ID NO: 861) is known.

[0353] As used herein, the term "hsa-miR-6752-5p gene" or "hsa-mi R-6752-5p" includes the hsa-miR-6752 -5p gene (miRBase Accession No. MIMAT0027404 ) described in SEQ ID NO: 855, as well as other species homologs or orthologs, etc. The hsa-miR-67 52-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22 volumes, p1634-1645. Also, "hsa -miR-6752-5p" has a hairpin-like structure as its precursor, "hsa-mi r-6752" (miRBase Accession No. MI0022597, sequence number 862) is known.

[0354] As used herein, the term "hsa-miR-4739 gene" or "hsa-miR-4 739" includes the hsa-miR-4739 gene (mi RBase Accession No. MIMAT0019868) described in SEQ ID NO: 856, as well as other species homologs or orthologs, etc. The hsa-miR-4739 gene can be obtained by the method described in Persson H et al., 2011, Cancer Res, 71 volumes, p78-86 . Also, "hsa-miR-4739" has a hairpin-like structure as its precursor, "hsa-mir-4739" (miRBase Acc ession No. MI0017377, sequence number 863) is known. ession No. MI0017377, sequence number 863) is known.

[0355] In addition, when mature miRNAs are excised as miRNA A from RNA precursors with a hairpin-like structure, 1 to several bases at the front and back of the sequence may be excised shorter or longer, or base substitutions may occur to form variants, which are called isomiRs (Morin R D. et al., 2008, Genome Res., Vol. 18, p. 610-621). In miR RBase Release20, in addition to the base sequences represented by any of SEQ ID NOs: 1 to 269 and 851 to 856, variant and fragment base sequences called numerous isomiRs, represented by any of SEQ ID NOs: 545 to 850 and 864 to 871, are also shown. These variants can also be obtained as miRNAs having the base sequences represented by any of SEQ ID NOs: 1 to 269 and 851 to 856. That is, SEQ ID NOs: 1, 2, 3, 4, 5, 6, 8, 11, 14, 15, 19, 20, 21, 23, 27, 28, 31, 35, 37, 38, 40, 42, 43, 47, 48, 50, 51, 52, 55, 56, 5 8, 60, 61, 62, 64, 65, 66, 67, 71, 72, 73, 76, 77, 78 3, 4, 5, 6, 8, 11, 14, 15, 19, 20, 21, 23, 27, 28, 31, 35, 37, 38, 40, 42, 43, 47, 48, 50, 51, 52, 55, 56, 5 8, 60, 61, 62, 64, 65, 66, 67, 71, 72, 73, 76, 77, 78 79, 80, 82, 83, 85, 86, 88, 89, 90, 92, 95, 97, 98, 99, 100, 102, 103, 107, 109, 110, 113, 114, 115, 1 16, 117, 118, 120, 122, 123, 126, 127, 129, 131, 1 33, 137, 141, 142, 143, 145, 146, 148, 149, 153, 1 54, 155, 156, 157, 161, 164, 165, 167, 168, 171, 1 72, 173, 178, 179, 180, 181, 182, 184, 185, 188, 1 91, 192, 194, 195, 196, 199, 201, 202, 204, 207, 2 10, 213, 215, 217, 219, 222, 223, 225, 230, 232, 2 33, 234, 235, 236, 238, 239, 240, 241, 242, 243, 2 45, 246, 247, 248, 249, 250, 251, 252, 254, 258, 2 59, 260, 263, 265, 266, 267, 851, 853, 854 and 856 or a polynucleotide variant consisting of the nucleotide sequence represented by these or a nucleotide sequence in which u is t in the nucleotide sequence Among the variants of the polynucleotide, for example, the longest variant registered in miRBase Release 20 is SEQ ID NO: 545, 547, 549, 551, 553, 5 55, 557, 559, 561, 563, 565, 567, 569, 571, 573, 5 75, 577, 579, 581, 583, 585, 587, 589, 591, 593, 5 95, 597, 599, 601, 603, 605, 607, 609, 611, 613, 6 15, 617, 619, 621, 623, 625, 627, 629, 631, 633, 6 35, 637, 639, 641, 643, 645, 647, 649, 651, 653, 6 55, 657, 659, 661, 663, 665, 667, 669, 671, 673, 6 75, 677, 679, 681, 683, 685, 687, 689, 691, 693, 6 95, 697, 699, 701, 703, 705, 707, 709, 711, 713, 7 15, 717, 719, 721, 723, 725, 727, 729, 731, 733, 7 35, 737, 739, 741, 743, 745, 747, 749, 751, 753, 7 55, 757, 759, 761, 763, 765, 767, 769, 771, 773, 7 55, 757, 759, 761, 763, 765, 767, 769, 771, 773, 7 75, 777, 779, 781, 783, 785, 787, 789, 791, 793, 7 95, 797, 799, 801, 803, 805, 807, 809, 811, 813, 8 15, 817, 819, 821, 823, 825, 827, 829, 831, 833, 8 35, 837, 839, 841, 843, 845, 847, 849, 864, 866, 8 Polynucleotides represented by 868 and 870 are included. Also, SEQ ID NO: 1 of the present invention, 2, 3, 4, 5, 6, 8, 11, 14, 15, 19, 20, 21, 23, 27, 28, 3 1, 35, 37, 38, 40, 42, 43, 47, 48, 50, 51, 52, 55, 56 , 58, 60, 61, 62, 64, 65, 66, 67, 71, 72, 73, 76, 77, 78, 79, 80, 82, 83, 85, 86, 88, 89, 90, 92, 95, 97, 9 8, 99, 100, 102, 103, 107, 109, 110, 113, 114, 115 , 116, 117, 118, 120, 122, 123, 126, 127, 129, 131 , 133, 137, 141, 142, 143, 145, 146, 148, 149, 153 , 154, 155, 156, 157, 161, 164, 165, 167, 168, 171 , 172, 173, 178, 179, 180, 181, 182, 184, 185, 188 , 191, 192, 194, 195, 196, 199, 201, 202, 204, 207 , 210, 213, 215, 217, 219, 222, 223, 225, 230, 232 , 233, 234, 235, 236, 238, 239, 240, 241, 242, 243 , 245, 246, 247, 248, 249, 250, 251, 252, 254, 258 , 259, 260, 263, 265, 266, 267, 851, 853, 854 and 85 A polynucleotide consisting of the nucleotide sequence represented by 6 or a nucleotide sequence in which u is t in the nucleotide sequence Among the variants of, for example, those registered in miRBase Release 20 As the shortest variant, SEQ ID NOs: 546, 548, 550, 552, 55 4, 556, 558, 560, 562, 564, 566, 568, 570, 572, 57 4, 576, 578, 580, 582, 584, 586, 588, 590, 592, 59 4, 596, 598, 600, 602, 604, 606, 608, 610, 612, 61 4, 616, 618, 620, 622, 624, 626, 628, 630, 632, 63 4, 636, 638, 640, 642, 644, 646, 648, 650, 652, 65 4, 656, 658, 660, 662, 664, 666, 668, 670, 672, 67 4, 676, 678, 680, 682, 684, 686, 688, 690, 692, 69 4, 696, 698, 700, 702, 704, 706, 708, 710, 712, 71 4, 716, 718, 720, 722, 724, 726, 728, 730, 732, 73 4, 736, 738, 740, 742, 744, 746, 748, 750, 752, 75 4, 756, 758, 760, 762, 764, 766, 768, 770, 772, 77 4, 776, 778, 780, 782, 784, 786, 788, 790, 792, 79 4, 796, 798, 800, 802, 804, 806, 808, 810, 812, 81 4, 816, 818, 820, 822, 824, 826, 828, 830, 832, 83 4, 836, 838, 840, 842, 844, 846, 848, 850, 865, 86 7. Polynucleotides of the sequences represented by 869 and 871 are included. Also, in addition to these variants and fragments, polynucleotides that are various isomiRs registered in miRBase with SEQ ID NOs: 1 to 269 and 851 to 856 are included. Furthermore, examples of polynucleotides containing the base sequences represented by any of SEQ ID NOs: 1 to 269 and 851 to 856 include polynucleotides represented by any of SEQ ID NOs: 270 to 544 and 857 to 863, which are each a precursor.

[0356] The names of the genes represented by SEQ ID NOs: 1 to 871 and the miRBase Accession No. (registration number) are listed in Table 1.

[0357] As used herein, "specifically bindable" means that the nucleic acid probe or primer used in the present invention binds to a specific target nucleic acid and cannot substantially bind to other nucleic acids.

[0358]

Table 1

Advantages of the Invention

[0359] According to the present invention, it has become possible to easily and accurately detect breast cancer. For example, using the measured values of several miRNAs in the blood, serum, and / or plasma of patients that can be collected in a minimally invasive manner as an indicator so that it is possible to easily detect whether a patient has breast cancer or not.

Brief Description of Drawings

[0360]

Figure 1

Figure 2

Figure 3

Figure 4

Mode for Carrying Out the Invention

[0361] The present invention will be described more specifically below. 1. Target Nucleic Acid for Breast Cancer Using the nucleic acid probe or primer for detecting breast cancer as defined above in the present invention, for detecting the presence and / or absence of breast cancer or breast cancer cells, the main target nucleic acids as breast cancer markers include hsa-miR-4783-3p, hsa-miR-4730, hsa- miR-1307-3p, hsa-miR-4634, hsa-miR-663a, hs a-miR-4532, hsa-miR-7704, hsa-miR-3178, hsa -miR-6729-5p, hsa-miR-6090, hsa-miR-4732-5 p, hsa-miR-3184-5p, hsa-miR-6727-5p, hsa-mi R-6088, hsa-miR-4674, hsa-miR-8073, hsa-miR -4787-5p, hsa-miR-1469, hsa-miR-125a-3p, hs a-miR-1233-5p, hsa-miR-885-3p, hsa-miR-680 2-5p, hsa-miR-328-5p, hsa-miR-6787-5p, hsa- miR-8069, hsa-miR-6875-5p, hsa-miR-1246, hs a-miR-4734, hsa-miR-6757-5p, hsa-miR-6756- 5p, hsa-miR-3665, hsa-miR-6836-3p, hsa-miR- 6821-5p, hsa-miR-6805-5p, hsa-miR-4728-5p, hsa-miR-6726-5p, hsa-miR-197-5p, hsa-miR-1 49-3p, hsa-miR-6850-5p, hsa-miR-4476, hsa-m iR-6858-5p, hsa-miR-564, hsa-miR-4763-3p, h sa-miR-575, hsa-miR-6771-5p, hsa-miR-1231, hsa-miR-1908-3p, hsa-miR-150-3p, hsa-miR-3 937, hsa-miR-887-3p, hsa-miR-3940-5p, hsa-m iR-4741, hsa-miR-6808-5p, hsa-miR-6869-5p, hsa-miR-5090, hsa-miR-615-5p, hsa-miR-8072 、hsa-miR-128-1-5p, hsa-miR-1238-5p, hsa-mi R-365a-5p, hsa-miR-204-3p, hsa-miR-4492, hs a-miR-6785-5p, hsa-miR-6511a-5p, hsa-miR-4 525, hsa-miR-1915-5p, hsa-miR-3180, hsa-miR -6879-5p, hsa-miR-1199-5p, hsa-miR-6746-5p , hsa-miR-711, hsa-miR-663b, hsa-miR-4707-3 p, hsa-miR-6893-5p, hsa-miR-4675, hsa-miR-4 638-5p, hsa-miR-4651, hsa-miR-6087, hsa-miR -4665-5p, hsa-miR-4758-5p, hsa-miR-6887-5p , hsa-miR-3620-5p, hsa-miR-1909-3p, hsa-miR -7641, hsa-miR-6724-5p, hsa-miR-1343-3p, hs a-miR-6780b-5p, hsa-miR-4484, hsa-miR-4690 -5p, hsa-miR-4429, hsa-miR-1227-5p, hsa-miR -4725-3p, hsa-miR-6861-5p, hsa-miR-6812-5p , hsa-miR-3197, hsa-miR-8059, hsa-miR-3185, hsa-miR-4706, hsa-miR-4497, hsa-miR-3131, h sa-miR-6806-5p, hsa-miR-187-5p, hsa-miR-31 80-3p, hsa-miR-6848-5p, hsa-miR-6820-5p, hs a-miR-6800-5p, hsa-miR-6717-5p, hsa-miR-67 95-5p, hsa-miR-4632-5p, hsa-miR-665, hsa-mi R-6778-5p, hsa-miR-3663-3p, hsa-miR-4689, h sa-miR-211-3p, hsa-miR-6511b-5p, hsa-miR-4 750-5p, hsa-miR-6126, hsa-miR-614, hsa-miR- 7110-5p, hsa-miR-744-5p, hsa-miR-6769a-5p, hsa-miR-4792, hsa-miR-5787, hsa-miR-6798-5 p, hsa-miR-6781-5p, hsa-miR-4419b, hsa-miR- 4446-3p, hsa-miR-4259, hsa-miR-5572, hsa-mi R-6075, hsa-miR-296-3p, hsa-miR-6891-5p, hs a-miR-4745-5p, hsa-miR-6775-5p, hsa-miR-68 70-5p, hsa-miR-920, hsa-miR-4530, hsa-miR-6 819-5p, hsa-miR-6825-5p, hsa-miR-7847-3p, h sa-miR-6131, hsa-miR-4433-3p, hsa-miR-1228 -5p, hsa-miR-6743-5p, hsa-miR-1268a, hsa-mi R-3917, hsa-miR-6786-5p, hsa-miR-3154, hsa- miR-638, hsa-miR-6741-5p, hsa-miR-6889-5p, hsa-miR-6840-3p, hsa-miR-6510-5p, hsa-miR- 3188, hsa-miR-551b-5p, hsa-miR-5001-5p, hsa -miR-1268b, hsa-miR-7107-5p, hsa-miR-6824- 5p, hsa-miR-6732-5p, hsa-miR-371a-5p, hsa-m iR-6794-5p, hsa-miR-6779-5p, hsa-miR-4271, hsa-miR-5195-3p, hsa-miR-6762-5p, hsa-miR- 939 - 5p, hsa - miR - 1247 - 3p, hsa - miR - 6777 - 5p, h sa - miR - 6722 - 3p, hsa - miR - 3656, hsa - miR - 4688 , hsa - miR - 3195, hsa - miR - 6766 - 5p, hsa - miR - 44 47, hsa - miR - 4656, hsa - miR - 7108 - 5p, hsa - miR - 3191 - 3p, hsa - miR - 1273g - 3p, hsa - miR - 4463, hs a - miR - 2861, hsa - miR - 3196, hsa - miR - 6877 - 5p, hsa - miR - 3679 - 5p, hsa - miR - 4442, hsa - miR - 678 9 - 5p, hsa - miR - 6782 - 5p, hsa - miR - 486 - 3p, hsa - miR - 6085, hsa - miR - 4746 - 3p, hsa - miR - 619 - 5p, hsa - miR - 937 - 5p, hsa - miR - 6803 - 5p, hsa - miR - 4 298, hsa - miR - 4454, hsa - miR - 4459, hsa - miR - 71 50, hsa - miR - 6880 - 5p, hsa - miR - 4449, hsa - miR - 8063, hsa - miR - 4695 - 5p, hsa - miR - 6132, hsa - mi R - 6829 - 5p, hsa - miR - 4486, hsa - miR - 6805 - 3p, h sa - miR - 6826 - 5p, hsa - miR - 4508, hsa - miR - 1343 - 5p, hsa - miR - 7114 - 5p, hsa - miR - 3622a - 5p, hsa - miR - 6765 - 5p, hsa - miR - 7845 - 5p, hsa - miR - 396 0, hsa - miR - 6749 - 5p, hsa - miR - 1260b, hsa - miR - 6799-5p, hsa-miR-4723-5p, hsa-miR-6784-5p, hsa-miR-5100, hsa-miR-6769b-5p, hsa-miR-12 07-5p, hsa-miR-642a-3p, hsa-miR-4505, hsa-m iR-4270, hsa-miR-6721-5p, hsa-miR-7111-5p, hsa-miR-6791-5p, hsa-miR-7109-5p, hsa-miR- 4258, hsa-miR-6515-3p, hsa-miR-6851-5p, hsa -miR-6125, hsa-miR-4749-5p, hsa-miR-4726-5 p, hsa-miR-4513, hsa-miR-6089, hsa-miR-6816 -5p, hsa-miR-4466, hsa-miR-4488, hsa-miR-67 at least one miRNA selected from the group consisting of 52-5p and hsa-miR-4739 can be used. Furthermore, other breast cancer markers that can be combined with these miRNAs, namely, hsa-miR-760, hsa-miR-602, h iRNA can be used. Furthermore, other breast cancer markers that can be combined with these miRNAs sa-miR-423-5p, hsa-miR-92a-2-5p, hsa-miR-1 6-5p, hsa-miR-451a, hsa-miR-135a-3p, hsa-mi R-486-5p, hsa-miR-4257, hsa-miR-92b-5p, hsa -miR-1915-3p, hsa-miR-718, hsa-miR-940, hsa -miR-296-5p, hsa-miR-23b-3p, and hsa-miR-92a- 3p, at least one miRNA selected from the group consisting of can also be preferably used as a target nucleic acid. Furthermore, other breast cancer markers that can be combined with these miRNAs can be used. arkers - car, that is, hsa-miR-658, hsa-miR-6842-5p, hsa - miR-6124, hsa-miR-6765-3p, hsa-miR-7106-5 p, hsa-miR-4534, hsa-miR-92b-3p, hsa-miR-31 35b, hsa-miR-4687-3p, hsa-miR-762, hsa-miR- 3619-3p, hsa-miR-4467, hsa-miR-557, hsa-miR - 1237-5p, hsa-miR-1908-5p, hsa-miR-4286, hs a-miR-6885-5p and at least one miRNA selected from the group consisting of hsa-miR-6763-5p can also be preferably used as a target nucleic acid.

[0362] The above miRNAs include, for example, human genes containing the nucleotide sequences represented by any of SEQ ID NOs: 1 to 269 and 851 to 856 (that is, hsa-miR-4783- 3p, hsa-miR-4730, hsa-miR-1307-3p, hsa-miR- 4634, hsa-miR-663a, hsa-miR-4532, hsa-miR-7 704, hsa-miR-3178, hsa-miR-6729-5p, hsa-miR - 6090, hsa-miR-4732-5p, hsa-miR-3184-5p, hs a-miR-6727-5p, hsa-miR-6088, hsa-miR-4674, hsa-miR-8073, hsa-miR-4787-5p, hsa-miR-146 9, hsa-miR-125a-3p, hsa-miR-1233-5p, hsa-mi R-885-3p, hsa-miR-6802-5p, hsa-miR-328-5p, hsa-miR-6787-5p, hsa-miR-8069, hsa-miR-687 5-5p, hsa-miR-1246, hsa-miR-4734, hsa-miR-6 757-5p, hsa-miR-6756-5p, hsa-miR-3665, hsa- miR-6836-3p, hsa-miR-6821-5p, hsa-miR-6805 -5p, hsa-miR-4728-5p, hsa-miR-6726-5p, hsa- miR-197-5p, hsa-miR-149-3p, hsa-miR-6850-5 p, hsa-miR-4476, hsa-miR-6858-5p, hsa-miR-5 64, hsa-miR-4763-3p, hsa-miR-575, hsa-miR-6 771-5p, hsa-miR-1231, hsa-miR-1908-3p, hsa- miR-150-3p, hsa-miR-3937, hsa-miR-887-3p, h sa-miR-3940-5p, hsa-miR-4741, hsa-miR-6808 -5p, hsa-miR-6869-5p, hsa-miR-5090, hsa-miR -615-5p, hsa-miR-8072, hsa-miR-128-1-5p, hs a-miR-1238-5p, hsa-miR-365a-5p, hsa-miR-20 4-3p, hsa-miR-4492, hsa-miR-6785-5p, hsa-mi R-6511a-5p, hsa-miR-4525, hsa-miR-1915-5p, hsa-miR-3180, hsa-miR-6879-5p, hsa-miR-119 9-5p, hsa-miR-6746-5p, hsa-miR-711, hsa-miR -663b, hsa-miR-4707-3p, hsa-miR-6893-5p, hs a-miR-4675, hsa-miR-4638-5p, hsa-miR-4651, hsa-miR-6087, hsa-miR-4665-5p, hsa-miR-475 8-5p, hsa-miR-6887-5p, hsa-miR-3620-5p, hsa -miR-1909-3p, hsa-miR-7641, hsa-miR-6724-5 p, hsa-miR-1343-3p, hsa-miR-6780b-5p, hsa-m iR-4484, hsa-miR-4690-5p, hsa-miR-4429, hsa -miR-1227-5p, hsa-miR-4725-3p, hsa-miR-686 1-5p, hsa-miR-6812-5p, hsa-miR-3197, hsa-mi R-8059, hsa-miR-3185, hsa-miR-4706, hsa-miR -4497, hsa-miR-3131, hsa-miR-6806-5p, hsa-m iR-187-5p, hsa-miR-3180-3p, hsa-miR-6848-5 p, hsa-miR-6820-5p, hsa-miR-6800-5p, hsa-mi R-6717-5p, hsa-miR-6795-5p, hsa-miR-4632-5 p, hsa-miR-665, hsa-miR-6778-5p, hsa-miR-36 63-3p, hsa-miR-4689, hsa-miR-211-3p, hsa-mi R-6511b-5p, hsa-miR-4750-5p, hsa-miR-6126, hsa-miR-614, hsa-miR-7110-5p, hsa-miR-744- 5p, hsa-miR-6769a-5p, hsa-miR-4792, hsa-miR -5787, hsa-miR-6798-5p, hsa-miR-6781-5p, hs a-miR-4419b, hsa-miR-4446-3p, hsa-miR-4259 , hsa-miR-5572, hsa-miR-6075, hsa-miR-296-3 p, hsa-miR-6891-5p, hsa-miR-4745-5p, hsa-mi R-6775-5p, hsa-miR-6870-5p, hsa-miR-920, hs a-miR-4530, hsa-miR-6819-5p, hsa-miR-6825- 5p, hsa-miR-7847-3p, hsa-miR-6131, hsa-miR- 4433-3p, hsa-miR-1228-5p, hsa-miR-6743-5p, hsa-miR-1268a, hsa-miR-3917, hsa-miR-6786- 5p, hsa-miR-3154, hsa-miR-638, hsa-miR-6741 -5p, hsa-miR-6889-5p, hsa-miR-6840-3p, hsa- miR-6510-5p, hsa-miR-3188, hsa-miR-551b-5p , hsa-miR-5001-5p, hsa-miR-1268b, hsa-miR-7 107-5p, hsa-miR-6824-5p, hsa-miR-6732-5p, h sa-miR-371a-5p, hsa-miR-6794-5p, hsa-miR-6 779-5p, hsa-miR-4271, hsa-miR-5195-3p, hsa- miR-6762-5p, hsa-miR-939-5p, hsa-miR-1247- 3p, hsa-miR-6777-5p, hsa-miR-6722-3p, hsa-m iR-3656, hsa-miR-4688, hsa-miR-3195, hsa-mi R-6766-5p, hsa-miR-4447, hsa-miR-4656, hsa- miR-7108-5p, hsa-miR-3191-3p, hsa-miR-1273 g-3p, hsa-miR-4463, hsa-miR-2861, hsa-miR-3 196, hsa-miR-6877-5p, hsa-miR-3679-5p, hsa- miR-4442, hsa-miR-6789-5p, hsa-miR-6782-5p , hsa-miR-486-3p, hsa-miR-6085, hsa-miR-474 6-3p, hsa-miR-619-5p, hsa-miR-937-5p, hsa-m iR-6803-5p, hsa-miR-4298, hsa-miR-4454, hsa -miR-4459, hsa-miR-7150, hsa-miR-6880-5p, h sa-miR-4449, hsa-miR-8063, hsa-miR-4695-5p , hsa-miR-6132, hsa-miR-6829-5p, hsa-miR-44 86, hsa-miR-6805-3p, hsa-miR-6826-5p, hsa-m iR-4508, hsa-miR-1343-5p, hsa-miR-7114-5p, hsa-miR-3622a-5p, hsa-miR-6765-5p, hsa-miR -7845-5p, hsa-miR-3960, hsa-miR-6749-5p, hs a-miR-1260b, hsa-miR-6799-5p, hsa-miR-4723 -5p, hsa-miR-6784-5p, hsa-miR-5100, hsa-miR -6769b-5p, hsa-miR-1207-5p, hsa-miR-642a-3 p, hsa-miR-4505, hsa-miR-4270, hsa-miR-6721 -5p, hsa-miR-7111-5p, hsa-miR-6791-5p, hsa- miR-7109-5p, hsa-miR-4258, hsa-miR-6515-3p , hsa-miR-6851-5p, hsa-miR-6125, hsa-miR-47 49-5p, hsa-miR-4726-5p, hsa-miR-4513, hsa-m iR-6089, hsa-miR-6816-5p, hsa-miR-4466, hsa -miR-4488, hsa-miR-6752-5p, hsa-miR-4739, h sa-miR-760, hsa-miR-602, hsa-miR-423-5p, hs a-miR-92a-2-5p, hsa-miR-16-5p, hsa-miR-451 a, hsa-miR-135a-3p, hsa-miR-486-5p, hsa-miR -4257, hsa-miR-92b-5p, hsa-miR-1915-3p, hsa -miR-718, hsa-miR-940, hsa-miR-296-5p, hsa- miR-23b-3p, hsa-miR-92a-3p, hsa-miR-658, hs a-miR-6842-5p, hsa-miR-6124, hsa-miR-6765- 3p, hsa-miR-7106-5p, hsa-miR-4534, hsa-miR- 92b-3p, hsa-miR-3135b, hsa-miR-4687-3p, hsa -miR-762, hsa-miR-3619-3p, hsa-miR-4467, hs a-miR-557, hsa-miR-1237-5p, hsa-miR-1908-5 p, hsa-miR-4286, hsa-miR-6885-5p and hsa-miR- It includes 6763 - 5p), its homologs, its transcription products, and its mutants or derivatives. Here, the gene, homologs, transcription products, mutants, and derivatives are as defined above.

[0363] A preferred target nucleic acid is a human gene containing the nucleotide sequence represented by any of SEQ ID NOs: 1 to 871, or its transcription product, more preferably the transcription product, that is, miRNA, its precursor RNA, pri - miRNA or pre - miRNA.

[0364] The first target gene is the hsa - miR - 4783 - 3p gene, its homologs, its transcription products, or its mutants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0365] The second target gene is the hsa - miR - 4730 gene, its homologs, its transcripts, or its mutants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0366] The third target gene is the hsa - miR - 1307 - 3p gene, its homologs, its transcription products, or its mutants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0367] The fourth target gene is the hsa - miR - 4634 gene, its homologs, its transcripts, or its mutants or derivatives. So far, there has been no report that changes in the expression of this gene or its There is no report indicating that changes in the expression of substances can be markers for breast cancer.

[0368] The fifth target gene is the hsa-miR-663a gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report indicating that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0369] The sixth target gene is the hsa-miR-4532 gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report indicating that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0370] The seventh target gene is the hsa-miR-7704 gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report indicating that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0371] The eighth target gene is the hsa-miR-3178 gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report indicating that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0372] The ninth target gene is the hsa-miR-6729-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report indicating that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0373] The 10th target gene is the hsa-miR-6090 gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0374] The 11th target gene is the hsa-miR-4732-5p gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0375] The 12th target gene is the hsa-miR-3184-5p gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0376] The 13th target gene is the hsa-miR-6727-5p gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0377] The 14th target gene is the hsa-miR-6088 gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0378] The 15th target gene is the hsa-miR-4674 gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its There is no report that changes in the expression of the product can be a marker for breast cancer.

[0379] The 16th target gene is the hsa-miR-8073 gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0380] The 17th target gene is the hsa-miR-4787-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0381] The 18th target gene is the hsa-miR-1469 gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0382] The 19th target gene is the hsa-miR-125a-3p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0383] The 20th target gene is the hsa-miR-1233-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0384] The 21st target gene is the hsa-miR-885-3p gene, its homologs, and The gene is a transcription product of the present invention, or a mutant or derivative thereof. There are no known reports that altered transcript expression could be a marker for breast cancer.

[0385] The 22nd target gene is the hsa-miR-6802-5p gene, its homologs, and The gene or its variants or derivatives are the transcription products of the gene or its variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for breast cancer.

[0386] The 23rd target gene is the hsa-miR-328-5p gene, its homologs, and The gene is a transcription product of the present invention, or a mutant or derivative thereof. There are no known reports that altered transcript expression could be a marker for breast cancer.

[0387] The 24th target gene is the hsa-miR-6787-5p gene, its homologs, and The gene or its variants or derivatives are the transcription products of the gene or its variants or derivatives. There are no known reports suggesting that changes in the expression of this transcript could be a marker for breast cancer.

[0388] The 25th target gene is the hsa-miR-8069 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof, has been There are no known reports indicating that changes in expression of the products could be markers for breast cancer.

[0389] The 26th target gene is the hsa-miR-6875-5p gene, its homologs, and They are these transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0390] The 27th target gene is the hsa-miR-1246 gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. They are these transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0391] The 28th target gene is the hsa-miR-4734 gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. They are these transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0392] The 29th target gene is the hsa-miR-6757-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. They are these transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0393] The 30th target gene is the hsa-miR-6756-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. They are these transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0394] The 31st target gene is the hsa-miR-3665 gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. They are these transcription products, or their mutants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0395] The 32nd target gene is the hsa-miR-6836-3p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there is no report indicating that changes in the expression of this gene or its transcription

[0396] products can be used as markers for breast cancer. The 33rd target gene is the hsa-miR-6821-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there is no report

[0397] indicating that changes in the expression of this gene or its transcription products can be used as markers for breast cancer. The 34th target gene is the hsa-miR-6805-5p gene, its homologs, their

[0398] transcription products, or their mutants or derivatives. So far, there is no report indicating that changes in the expression of this gene or its transcription products can be used as markers for breast cancer.

[0399] The 36th target gene is the hsa-miR-6726-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there is no report indicating that changes in the expression of this gene or its transcription

[0400] products can be used as markers for breast cancer. The 37th target gene is the hsa-miR-197-5p gene, its homologs, itself is a transcription product thereof, or a variant or derivative thereof. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0401] The 38th target gene is the hsa-miR-149-3p gene, its homologs, their transcription products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0402] The 39th target gene is the hsa-miR-6850-5p gene, its homologs, their transcription products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0403] The 40th target gene is the hsa-miR-4476 gene, its homologs, their transcription products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0404] The 41st target gene is the hsa-miR-6858-5p gene, its homologs, their transcription products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0405] The 42nd target gene is the hsa-miR-564 gene, its homologs, their transcripts products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription product Reports indicating that changes in the expression of substances can serve as markers for breast cancer are not known.

[0406] The 43rd target gene is the hsa-miR-4763-3p gene, its homologs, their transcription products, or their variants or derivatives. Reports suggesting that changes in the expression of this gene or its transcription products can serve as markers for breast cancer are not known.

[0407] The 44th target gene is the hsa-miR-575 gene, its homologs, their transcripts, or their variants or derivatives. Reports suggesting that changes in the expression of this gene or its transcription products can serve as markers for breast cancer are not known.

[0408] The 45th target gene is the hsa-miR-6771-5p gene, its homologs, their transcription products, or their variants or derivatives. Reports suggesting that changes in the expression of this gene or its transcription products can serve as markers for breast cancer are not known.

[0409] The 46th target gene is the hsa-miR-1231 gene, its homologs, their transcription products, or their variants or derivatives. Reports suggesting that changes in the expression of this gene or its transcription products can serve as markers for breast cancer are not known.

[0410] The 47th target gene is the hsa-miR-1908-3p gene, its homologs, their transcription products, or their variants or derivatives. Reports suggesting that changes in the expression of this gene or its transcription products can serve as markers for breast cancer are not known.

[0411] The 48th target gene is the hsa-miR-150-3p gene, its homologs, their transcripts, or their mutants or derivatives. There has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer.

[0412] The 49th target gene is the hsa-miR-3937 gene, its homologs, their transcripts, or their mutants or derivatives. There has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer.

[0413] The 50th target gene is the hsa-miR-887-3p gene, its homologs, their transcripts, or their mutants or derivatives. There has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer.

[0414] The 51st target gene is the hsa-miR-3940-5p gene, its homologs, their transcripts, or their mutants or derivatives. There has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer.

[0415] The 52nd target gene is the hsa-miR-4741 gene, its homologs, their transcripts, or their mutants or derivatives. There has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer.

[0416] The 53rd target gene is the hsa-miR-6808-5p gene, its homologs, their transcripts, or their mutants or derivatives. There has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. So far, there has been no report that changes in the expression of this gene or its transcripts can be a marker for breast cancer. There is no report that changes in the expression of the transcript of can be a marker for breast cancer.

[0417] The 54th target gene is the hsa-miR-6869-5p gene, its homologs, their transcripts, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0418] The 55th target gene is the hsa-miR-5090 gene, its homologs, their transcripts, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0419] The 56th target gene is the hsa-miR-615-5p gene, its homologs, it their transcripts, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0420] The 57th target gene is the hsa-miR-8072 gene, its homologs, their transcripts, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0421] The 58th target gene is the hsa-miR-128-1-5p gene, its homologs, their transcripts, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0422] The 59th target gene is the hsa-miR-1238-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report indicating that changes in the expression of this gene or its

[0423] transcription products can serve as markers for breast cancer. The 60th target gene is the hsa-miR-365a-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no

[0424] report indicating that changes in the expression of this gene or its transcription products can serve as markers for breast cancer. The 61st target gene is the hsa-miR-204-3p gene, its homologs, their

[0425] transcription products, or their mutants or derivatives. So far, there has been no report indicating that changes in the expression of this gene or its transcription products can serve as markers for breast cancer.

[0426] The 63rd target gene is the hsa-miR-6785-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report indicating that changes in the expression of this gene or its

[0427] transcription products can serve as markers for breast cancer. The 64th target gene is the hsa-miR-6511a-5p gene, its homologs, They are those transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0428] The 65th target gene is the hsa-miR-4525 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0429] The 66th target gene is the hsa-miR-1915-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0430] The 67th target gene is the hsa-miR-3180 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0431] The 68th target gene is the hsa-miR-6879-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0432] The 69th target gene is the hsa-miR-1199-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or There is no report that changes in the expression of the transcription product can be a marker for breast cancer.

[0433] The 70th target gene is the hsa-miR-6746-5p gene, its homologs, their transcription products, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0434] The 71st target gene is the hsa-miR-711 gene, its homologs, their transcripts, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0435] The 72nd target gene is the hsa-miR-663b gene, its homologs, their transcription products, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0436] The 73rd target gene is the hsa-miR-4707-3p gene, its homologs, their transcription products, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0437] The 74th target gene is the hsa-miR-6893-5p gene, its homologs, their transcription products, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0438] The 75th target gene is the hsa-miR-4675 gene, its homologs, their transcripts, or their variants or derivatives. There has been no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0439] The 76th target gene is the hsa-miR-4638-5p gene, its homologs, their transcripts, or their variants or derivatives. There has been no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0440] The 77th target gene is the hsa-miR-4651 gene, its homologs, their transcripts, or their variants or derivatives. There has been no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0441] The 78th target gene is the hsa-miR-6087 gene, its homologs, their transcripts, or their variants or derivatives. There has been no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0442] The 79th target gene is the hsa-miR-4665-5p gene, its homologs, their transcripts, or their variants or derivatives. There has been no report that changes in the expression of this gene or its transcript can be a marker for breast cancer.

[0443] The 80th target gene is the hsa-miR-4758-5p gene, its homologs, their transcripts, or their variants or derivatives. There is no report that changes in the expression of the transcription product of can be a marker for breast cancer.

[0444] The 81st target gene is the hsa-miR-6887-5p gene, its homologs, its transcription products, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0445] The 82nd target gene is the hsa-miR-3620-5p gene, its homologs, its transcription products, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0446] The 83rd target gene is the hsa-miR-1909-3p gene, its homologs, its transcription products, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0447] The 84th target gene is the hsa-miR-7641 gene, its homologs, its transcription products, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0448] The 85th target gene is the hsa-miR-6724-5p gene, its homologs, its transcription products, or their variants or derivatives. There is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0449] The 86th target gene is the hsa-miR-1343-3p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report indicating that changes in the expression of this gene or its

[0450] transcription products can serve as markers for breast cancer. The 87th target gene is the hsa-miR-6780b-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no

[0451] report indicating that changes in the expression of this gene or its transcription products can serve as markers for breast cancer. The 88th target gene is the hsa-miR-4484 gene, its homologs, their

[0452] transcription products, or their variants or derivatives. So far, there has been no report indicating that changes in the expression of this gene or its transcription products can serve as markers for breast cancer.

[0453] The 89th target gene is the hsa-miR-4690-5p gene, its homologs, its transcription products, or their variants or derivatives. So far, there has been no report indicating that changes in the expression of this gene or its

[0453] transcription products can serve as markers for breast cancer. The 90th target gene is the hsa-miR-4429 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no

[0454] report indicating that changes in the expression of this gene or its They are these transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0455] The 92nd target gene is the hsa-miR-4725-3p gene, its homologs, its transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0456] The 93rd target gene is the hsa-miR-6861-5p gene, its homologs, its transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0457] The 94th target gene is the hsa-miR-6812-5p gene, its homologs, its transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0458] The 95th target gene is the hsa-miR-3197 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0459] The 96th target gene is the hsa-miR-8059 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0460] The 97th target gene is the hsa-miR-3185 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0461] The 98th target gene is the hsa-miR-4706 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0462] The 99th target gene is the hsa-miR-4497 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0463] The 100th target gene is the hsa-miR-3131 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0464] The 101st target gene is the hsa-miR-6806-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0465] The 102nd target gene is the hsa-miR-187-5p gene, its homologs, They are these transcription products, or their mutants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0466] The 103rd target gene is the hsa-miR-3180-3p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0467] The 104th target gene is the hsa-miR-6848-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0468] The 105th target gene is the hsa-miR-6820-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0469] The 106th target gene is the hsa-miR-6800-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0470] The 107th target gene is the hsa-miR-6717-5p gene, its homologs, their transcription products, or their mutants or derivatives. So far, there has been no report that changes in the expression of this gene or There is no report that changes in the expression of the transcription product can be a marker for breast cancer.

[0471] The 108th target gene is the hsa-miR-6795-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0472] The 109th target gene is the hsa-miR-4632-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0473] The 110th target gene is the hsa-miR-665 gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0474] The 111th target gene is the hsa-miR-6778-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0475] The 112th target gene is the hsa-miR-3663-3p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that changes in the expression of this gene or its transcription product can be a marker for breast cancer.

[0476] The target gene of No. 113 is the hsa-miR-4689 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0477] The target gene of No. 114 is the hsa-miR-211-3p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0478] The target gene of No. 115 is the hsa-miR-6511b-5p gene, its homologs their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer. .

[0479] The target gene of No. 116 is the hsa-miR-4750-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0480] The target gene of No. 117 is the hsa-miR-6126 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0481] The target gene of No. 118 is the hsa-miR-614 gene, its homologs, their They are transcription products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0482] The 119th target gene is the hsa-miR-7110-5p gene, its homologs, their transcription products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0483] The 120th target gene is the hsa-miR-744-5p gene, its homologs, their transcription products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0484] The 121st target gene is the hsa-miR-6769a-5p gene, its homologs their transcription products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer. .

[0485] The 122nd target gene is the hsa-miR-4792 gene, its homologs, their transcription products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0486] The 123rd target gene is the hsa-miR-5787 gene, its homologs, their transcription products, or variants or derivatives thereof. So far, there has been no report that changes in the expression of this gene or its transcription There is no report indicating that the change in the expression of the writing product can be a marker for breast cancer.

[0487] The 124th target gene is the hsa-miR-6798-5p gene, its homologs, their transcripts, or their variants or derivatives. So far, there is no report indicating that the change in the expression of this gene or its transcript can be a marker for breast cancer.

[0488] The 125th target gene is the hsa-miR-6781-5p gene, its homologs, their transcripts, or their variants or derivatives. So far, there is no report indicating that the change in the expression of this gene or its transcript can be a marker for breast cancer.

[0489] The 126th target gene is the hsa-miR-4419b gene, its homologs, itself their transcripts, or their variants or derivatives. So far, there is no report indicating that the change in the expression of this gene or its transcript can be a marker for breast cancer.

[0490] The 127th target gene is the hsa-miR-4446-3p gene, its homologs, their transcripts, or their variants or derivatives. So far, there is no report indicating that the change in the expression of this gene or its transcript can be a marker for breast cancer.

[0491] The 128th target gene is the hsa-miR-4259 gene, its homologs, themselves their transcripts, or their variants or derivatives. So far, there is no report indicating that the change in the expression of this gene or its tran script can be a marker for breast cancer.

[0492] The 129th target gene is the hsa-miR-5572 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0493] The 130th target gene is the hsa-miR-6075 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0494] The 131st target gene is the hsa-miR-296-3p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0495] The 132nd target gene is the hsa-miR-6891-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0496] The 133rd target gene is the hsa-miR-4745-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that changes in the expression of this gene or its transcription products can be markers for breast cancer.

[0497] The 134th target gene is the hsa-miR-6775-5p gene, its homologs, They are those transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or the change in the expression of its transcription product can be a marker for breast cancer.

[0498] The 135th target gene is the hsa-miR-6870-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or the change in the expression of its transcription product can be a marker for breast cancer.

[0499] The 136th target gene is the hsa-miR-920 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0500] The 137th target gene is the hsa-miR-4530 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its trans cription product can be a marker for breast cancer.

[0501] The 138th target gene is the hsa-miR-6819-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or the change in the expression of its transcription product can be a marker for breast cancer.

[0502] The 139th target gene is the hsa-miR-6825-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or There is no report that the change in the expression of the transcription product can be a marker for breast cancer.

[0503] The 140th target gene is the hsa-miR-7847-3p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0504] The 141st target gene is the hsa-miR-6131 gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0505] The 142nd target gene is the hsa-miR-4433-3p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0506] The 143rd target gene is the hsa-miR-1228-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0507] The 144th target gene is the hsa-miR-6743-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0508] The 145th target gene is the hsa-miR-1268a gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report indicating that changes in the expression of this gene or its transcripts can

[0509] serve as a marker for breast cancer. The 146th target gene is the hsa-miR-3917 gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report

[0510] indicating that changes in the expression of this gene or its transcripts can serve as a marker for breast cancer. The 147th target gene is the hsa-miR-6786-5p gene, its homologs,

[0511] their transcripts, or their variants or derivatives. So far, there has been no report indicating that changes in the expression of this gene or its transcripts can serve as a marker for breast cancer.

[0512] The 149th target gene is the hsa-miR-638 gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report indicating that changes in the expression of this gene or its transcripts can

[0513] serve as a marker for breast cancer. The 150th target gene is the hsa-miR-6741-5p gene, its homologs, There is no report indicating that the change in the expression of its transcription product can be a marker for breast cancer.

[0514] The 151st target gene is the hsa-miR-6889-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report indicating that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0515] The 152nd target gene is the hsa-miR-6840-3p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report indicating that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0516] The 153rd target gene is the hsa-miR-6510-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report indicating that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0517] The 154th target gene is the hsa-miR-3188 gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report indicating that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0518] The 155th target gene is the hsa-miR-551b-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there is no report indicating that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0519] The 156th target gene is the hsa-miR-5001-5p gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcript can be a marker for breast cancer.

[0520] The 157th target gene is the hsa-miR-1268b gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcript can be a marker for breast cancer.

[0521] The 158th target gene is the hsa-miR-7107-5p gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcript can be a marker for breast cancer.

[0522] The 159th target gene is the hsa-miR-6824-5p gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcript can be a marker for breast cancer.

[0523] The 160th target gene is the hsa-miR-6732-5p gene, its homologs, their transcripts, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcript can be a marker for breast cancer.

[0524] The 161st target gene is the hsa-miR-371a-5p gene, its homologs, They are those transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0525] The 162nd target gene is the hsa-miR-6794-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0526] The 163rd target gene is the hsa-miR-6779-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0527] The 164th target gene is the hsa-miR-4271 gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its tran scription product can be a marker for breast cancer.

[0528] The 165th target gene is the hsa-miR-5195-3p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or its transcription product can be a marker for breast cancer.

[0529] The 166th target gene is the hsa-miR-6762-5p gene, its homologs, their transcription products, or their variants or derivatives. So far, there has been no report that the change in the expression of this gene or There is no report that the change in the expression of the transcription product can be a marker for breast cancer.

[0530] The 167th target gene is the hsa-miR-939-5p gene, its homologs, their transcription products, or their variants...

Claims

1. A kit for detecting breast cancer, comprising a nucleic acid that can specifically bind to miR-6757-5p, which is a breast cancer marker.

2. The nucleic acid is a polynucleotide represented by any of the following (1) to (5) or a fragment thereof: (1) a polynucleotide consisting of a nucleotide sequence complementary to the nucleotide sequence represented by SEQ ID NO: 29 or a nucleotide sequence in which u is t in the nucleotide sequence, or a fragment thereof containing 15 or more consecutive bases, (2) a polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of 1 or 2 bases in the nucleotide sequence of the polynucleotide or fragment thereof of (1), (3) a polynucleotide or a fragment thereof of (1) or (2) containing a modified nucleic acid and / or a modified nucleotide, (4) a polynucleotide containing a nucleotide sequence complementary to the nucleotide sequence represented by SEQ ID NO: 29 or a nucleotide sequence in which u is t in the nucleotide sequence, or a fragment thereof containing 15 or more consecutive bases, (5) a polynucleotide that hybridizes under highly stringent conditions with a polynucleotide represented by any of the following (a) to (d) or a fragment thereof, (a) a polynucleotide consisting of the nucleotide sequence represented by SEQ ID NO: 29 or a nucleotide sequence in which u is t in the nucleotide sequence, or a fragment thereof containing 15 or more consecutive bases, (b) a polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of 1 or 2 bases in the nucleotide sequence of the polynucleotide or fragment thereof of (a), (c) a polynucleotide or a fragment thereof of (a) or (b) containing a modified nucleic acid and / or a modified nucleotide, and (d) a polynucleotide containing the nucleotide sequence represented by SEQ ID NO: 29 or a nucleotide sequence in which u is t in the nucleotide sequence, or a fragment thereof containing 15 or more consecutive bases, The kit according to claim 1, selected from the group consisting of.

3. The kit is another breast cancer marker, miR-4783-3p, miR-1307-3p, miR-4634, miR-663a, miR-4532, miR-7704, miR-3178, miR-6729-5p, miR-6090, miR-4732-5p, miR-3184-5p, miR-6727-5p, miR-6088, miR-4674, miR-8073, miR-4787-5p, miR-1469, miR-125a-3p, miR-1233-5p, miR-885-3p, miR-6802-5p, miR-328-5p, miR-6787-5p, miR-8069, miR-6875-5p, miR-1246, miR-4734, miR-6756-5p, miR-3665, miR-6821-5p, miR-6805-5p, miR-4728-5p, miR-6726-5p, miR-197-5p, miR-149-3p, miR-6850-5p, miR-4476, miR-6858-5p, miR-564, miR-4763-3p, miR-575, miR-6771-5p, miR-1231, miR-1908-3p, miR-150-3p, miR-3937, miR-887-3p, miR-3940-5p, miR-4741, miR-6808-5p, miR-6869-5p, miR-5090, miR-615-5p, miR-8072, miR-128-1-5p, miR-1238-5p, miR-365a-5p, miR-204-3p, miR-4492, miR-6785-5p, miR-6511a-5p, miR-4525, miR-1915-5p, miR-3180, miR-6879-5p, miR-1199-5p, miR-6746-5p, miR-711, miR-663b, miR-4707-3p, miR-6893-5p, miR-4675, miR-4638-5p, miR-4651, miR-6087, miR-4665-5p, miR-4758-5p, miR-6887-5p, miR-3620-5p, miR-1909-3p, miR-7641, miR-6724-5p, miR-1343-3p, miR-6780b-5p, miR-4484, miR-4690-5p, miR-4429, miR-1227-5p, miR-4725-3p, miR-6861-5p,miR-6812-5p, miR-3197, miR-8059, miR-3185, miR-4706, miR-4497, miR-3131, miR-6806-5p, miR-187-5p, miR-3180-3p, miR-6848-5p, miR-6820-5p, miR-6800-5p, miR-6717-5p, miR-6795-5p, miR-4632-5p, miR-6778-5p, miR-3663-3p, miR-4689, miR-211-3p, miR-6511b-5p, miR-4750-5p, miR-6126, miR-614, miR-7110-5p, miR-744-5p, miR-6769a-5p, miR-4792, miR-5787, miR-6798-5p, miR-6781-5p, miR-4419b, miR-4446-3p, miR-4259, miR-5572, miR-6075, miR-296-3p, miR-6891-5p, miR-4745-5p, miR-6775-5p, miR-6870-5p, miR-920, miR-4530, miR-6819-5p, miR-6825-5p, miR-7847-3p, miR-6131, miR-4433-3p, miR-1228-5p, miR-6743-5p, miR-1268a, miR-3917, miR-6786-5p, miR-3154, miR-638, miR-6741-5p, miR-6889-5p, miR-6840-3p, miR-6510-5p, miR-3188, miR-551b-5p, miR-5001-5p, miR-1268b, miR-7107-5p, miR-6824-5p, miR-6732-5p, miR-371a-5p, miR-6794-5p, miR-6779-5p, miR-4271, miR-5195-3p, miR-6762-5p, miR-939-5p, miR-1247-3p, miR-6777-5p, miR-6722-3p, miR-3656, miR-4688, miR-3195, miR-6766-5p, miR-4447, miR-4656, miR-7108-5p, miR-3191-3p, miR-1273g-3p, miR-4463, miR-2861, miR-3196, miR-6877-5p, miR-3679-5p, miR-4442, miR-6789-5pa nucleic acid that can specifically bind to at least one polynucleotide selected from the group consisting of miR-6782-5p, miR-486-3p, miR-6085, miR-4746-3p, miR-619-5p, miR-937-5p, miR-6803-5p, miR-4298, miR-4454, miR-4459, miR-7150, miR-6880-5p, miR-4449, miR-8063, miR-4695-5p, miR-6132, miR-6829-5p, miR-4486, miR-6805-3p, miR-6826-5p, miR-4508, miR-1343-5p, miR-7114-5p, miR-3622a-5p, miR-6765-5p, miR-7845-5p, miR-3960, miR-6749-5p, miR-1260b, miR-6799-5p, miR-4723-5p, miR-6784-5p, miR-5100, miR-6769b-5p, miR-1207-5p, miR-642a-3p, miR-4505, miR-4270, miR-6721-5p, miR-7111-5p, miR-6791-5p, miR-7109-5p, miR-4258, miR-6515-3p, miR-6851-5p, miR-6125, miR-4749-5p, miR-4726-5p, miR-4513, miR-6089, miR-6816-5p, miR-4466, miR-4488, miR-6752-5p, miR-4739, miR-760, miR-602, miR-423-5p, miR-92a-2-5p, miR-16-5p, miR-451a, miR-135a-3p, miR-486-5p, miR-4257, miR-92b-5p, miR-1915-3p, miR-718, miR-940, miR-296-5p, miR-23b-3p, miR-92a-3p, miR-658, miR-6842-5p, miR-6124, miR-6765-3p, miR-7106-5p, miR-4534, miR-92b-3p, miR-3135b, miR-4687-3p, miR-762, miR-3619-3p, miR-4467, miR-557, miR-1237-5p, miR-1908-5p, miR-4286, miR-6885-5p, and miR-6763-5p, further comprisingThe kit according to claim 1 or 2.

4. The nucleic acid is a polynucleotide represented by any of the following (6) to (10) or a fragment thereof: (6) a polynucleotide consisting of a nucleotide sequence complementary to the nucleotide sequence represented by any of SEQ ID NOs: 1, 3 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269 or a nucleotide sequence in which u is t in the nucleotide sequence, or a fragment thereof containing 15 or more consecutive bases, (7) a polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of 1 or 2 bases in the nucleotide sequence of the polynucleotide or fragment thereof of (6), The polynucleotide or fragment thereof according to (6) or (7) containing a modified nucleic acid and / or a modified nucleotide, The polynucleotide containing a base sequence represented by any of SEQ ID NOs: 1, 3 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269 or a base sequence complementary to the base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases, The polynucleotide that hybridizes under highly stringent conditions with the polynucleotide or fragment thereof according to any of the following (e) to (h), The polynucleotide consisting of a base sequence represented by any of SEQ ID NOs: 1, 3 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269 or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases, The polynucleotide or fragment thereof containing a deletion, substitution, addition or insertion of 1 or 2 bases in the base sequence of the polynucleotide or fragment thereof according to (e), The polynucleotide or fragment thereof according to (e) or (f) containing a modified nucleic acid and / or a modified nucleotide, and The polynucleotide containing a base sequence represented by any of SEQ ID NOs: 1, 3 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269 or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases The kit according to claim 3, selected from the group consisting of.

5. A device for detecting breast cancer, comprising a nucleic acid capable of specifically binding to miR-6757-5p, which is a breast cancer marker.

6. The nucleic acid is, The polynucleotide or fragment thereof shown in any of the following (1) to (5): The polynucleotide consisting of a base sequence represented by SEQ ID NO: 29 or a base sequence complementary to the base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases, The polynucleotide or fragment thereof containing a deletion, substitution, addition or insertion of 1 or 2 bases in the base sequence of the polynucleotide or fragment thereof according to (1), The polynucleotide or fragment thereof according to (1) or (2) containing a modified nucleic acid and / or a modified nucleotide, A polynucleotide comprising the nucleotide sequence represented by SEQ ID NO: 29 or a nucleotide sequence complementary to the nucleotide sequence in which u is t in said nucleotide sequence, or a fragment thereof containing 15 or more consecutive nucleotides, A polynucleotide that hybridizes under highly stringent conditions with a polynucleotide or a fragment thereof selected from any of the following (a) to (d): (a) A polynucleotide consisting of the nucleotide sequence represented by SEQ ID NO: 29 or the nucleotide sequence in which u is t in said nucleotide sequence, or a fragment thereof containing 15 or more consecutive nucleotides, (b) A polynucleotide or a fragment thereof containing a deletion, substitution, addition or insertion of 1 or 2 bases in the nucleotide sequence of the polynucleotide or the fragment thereof of (a), (c) A polynucleotide or a fragment thereof of (a) or (b) containing a modified nucleic acid and / or a modified nucleotide, and (d) A polynucleotide containing the nucleotide sequence represented by SEQ ID NO: 29 or the nucleotide sequence in which u is t in said nucleotide sequence, or a fragment thereof containing 15 or more consecutive nucleotides, The device according to claim 5, selected from the group consisting of:

7. The device is another breast cancer marker, miR-4783-3p, miR-1307-3p, miR-4634, miR-663a, miR-4532, miR-7704, miR-3178, miR-6729-5p, miR-6090, miR-4732-5p, miR-3184-5p, miR-6727-5p, miR-6088, miR-4674, miR-8073, miR-4787-5p, miR-1469, miR-125a-3p, miR-1233-5p, miR-885-3p, miR-6802-5p, miR-328-5p, miR-6787-5p, miR-8069, miR-6875-5p, miR-1246, miR-4734, miR-6756-5p, miR-3665, miR-6821-5p, miR-6805-5p, miR-4728-5p, miR-6726-5p, miR-197-5p, miR-149-3p, miR-6850-5p, miR-4476, miR-6858-5p, miR-564, miR-4763-3p, miR-575, miR-6771-5p, miR-1231, miR-1908-3p, miR-150-3p, miR-3937, miR-887-3p, miR-3940-5p, miR-4741, miR-6808-5p, miR-6869-5p, miR-5090, miR-615-5p, miR-8072, miR-128-1-5p, miR-1238-5p, miR-365a-5p, miR-204-3p, miR-4492, miR-6785-5p, miR-6511a-5p, miR-4525, miR-1915-5p, miR-3180, miR-6879-5p, miR-1199-5p, miR-6746-5p, miR-711, miR-663b, miR-4707-3p, miR-6893-5p, miR-4675, miR-4638-5p, miR-4651, miR-6087, miR-4665-5p, miR-4758-5p, miR-6887-5p, miR-3620-5p, miR-1909-3p, miR-7641, miR-6724-5p, miR-1343-3p, miR-6780b-5p, miR-4484, miR-4690-5p, miR-4429, miR-1227-5p, miR-4725-3p, miR-6861-5p,miR-6812-5p, miR-3197, miR-8059, miR-3185, miR-4706, miR-4497, miR-3131, miR-6806-5p, miR-187-5p, miR-3180-3p, miR-6848-5p, miR-6820-5p, miR-6800-5p, miR-6717-5p, miR-6795-5p, miR-4632-5p, miR-6778-5p, miR-3663-3p, miR-4689, miR-211-3p, miR-6511b-5p, miR-4750-5p, miR-6126, miR-614, miR-7110-5p, miR-744-5p, miR-6769a-5p, miR-4792, miR-5787, miR-6798-5p, miR-6781-5p, miR-4419b, miR-4446-3p, miR-4259, miR-5572, miR-6075, miR-296-3p, miR-6891-5p, miR-4745-5p, miR-6775-5p, miR-6870-5p, miR-920, miR-4530, miR-6819-5p, miR-6825-5p, miR-7847-3p, miR-6131, miR-4433-3p, miR-1228-5p, miR-6743-5p, miR-1268a, miR-3917, miR-6786-5p, miR-3154, miR-638, miR-6741-5p, miR-6889-5p, miR-6840-3p, miR-6510-5p, miR-3188, miR-551b-5p, miR-5001-5p, miR-1268b, miR-7107-5p, miR-6824-5p, miR-6732-5p, miR-371a-5p, miR-6794-5p, miR-6779-5p, miR-4271, miR-5195-3p, miR-6762-5p, miR-939-5p, miR-1247-3p, miR-6777-5p, miR-6722-3p, miR-3656, miR-4688, miR-3195, miR-6766-5p, miR-4447, miR-4656, miR-7108-5p, miR-3191-3p, miR-1273g-3p, miR-4463, miR-2861, miR-3196, miR-6877-5p, miR-3679-5p, miR-4442, miR-6789-5pa nucleic acid that can specifically bind to at least one polynucleotide selected from the group consisting of miR-6782-5p, miR-486-3p, miR-6085, miR-4746-3p, miR-619-5p, miR-937-5p, miR-6803-5p, miR-4298, miR-4454, miR-4459, miR-7150, miR-6880-5p, miR-4449, miR-8063, miR-4695-5p, miR-6132, miR-6829-5p, miR-4486, miR-6805-3p, miR-6826-5p, miR-4508, miR-1343-5p, miR-7114-5p, miR-3622a-5p, miR-6765-5p, miR-7845-5p, miR-3960, miR-6749-5p, miR-1260b, miR-6799-5p, miR-4723-5p, miR-6784-5p, miR-5100, miR-6769b-5p, miR-1207-5p, miR-642a-3p, miR-4505, miR-4270, miR-6721-5p, miR-7111-5p, miR-6791-5p, miR-7109-5p, miR-4258, miR-6515-3p, miR-6851-5p, miR-6125, miR-4749-5p, miR-4726-5p, miR-4513, miR-6089, miR-6816-5p, miR-4466, miR-4488, miR-6752-5p, miR-4739, miR-760, miR-602, miR-423-5p, miR-92a-2-5p, miR-16-5p, miR-451a, miR-135a-3p, miR-486-5p, miR-4257, miR-92b-5p, miR-1915-3p, miR-718, miR-940, miR-296-5p, miR-23b-3p, miR-92a-3p, miR-658, miR-6842-5p, miR-6124, miR-6765-3p, miR-7106-5p, miR-4534, miR-92b-3p, miR-3135b, miR-4687-3p, miR-762, miR-3619-3p, miR-4467, miR-557, miR-1237-5p, miR-1908-5p, miR-4286, miR-6885-5p, and miR-6763-5p, further comprisingThe device according to claim 5 or 6.,

8. The nucleic acid is a polynucleotide or a fragment thereof shown in any of the following (6) to (10): (6) A polynucleotide consisting of the nucleotide sequence represented by any of SEQ ID NOs: 1, 3 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269 or a nucleotide sequence complementary to the nucleotide sequence in which u is t in said nucleotide sequence, or a fragment thereof containing 15 or more consecutive nucleotides, (7) A polynucleotide or a fragment thereof containing a deletion, substitution, addition or insertion of 1 or 2 bases in the nucleotide sequence of the polynucleotide or the fragment thereof of (6), (8) A polynucleotide or a fragment thereof of (6) or (7) containing a modified nucleic acid and / or a modified nucleotide, (9) A polynucleotide containing the nucleotide sequence represented by any of SEQ ID NOs: 1, 3 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269 or a nucleotide sequence complementary to the nucleotide sequence in which u is t in said nucleotide sequence, and (10) A polynucleotide that hybridizes under highly stringent conditions with a polynucleotide or a fragment thereof selected from any of (e) to (h) above. (e) A polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1, 3 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269, or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases, (f) A polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of 1 or 2 bases in the base sequence of the polynucleotide or the fragment thereof in (e), (g) A polynucleotide or a fragment thereof in (e) or (f) containing a modified nucleic acid and / or a modified nucleotide, and (h) A polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1, 3 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269, or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases, The device according to claim 7, selected from the group consisting of.

9. Using the kit according to any one of claims 1 to 4 or the device according to any one of claims 5 to 8, measuring the expression level of each target nucleic acid in a specimen of a subject, and comparing the measured expression level with the control expression level of a healthy subject measured in the same manner, based on the amount of the expression level of the corresponding target nucleic acid of the subject relative to the expression level of each target nucleic acid of the healthy subject, a method for assisting the detection of breast cancer for in vitro evaluating that the subject has breast cancer.

10. The method according to claim 9, wherein the subject is a human.

11. The method according to claim 9 or 10, wherein the specimen is blood, serum, or plasma.

12. Use of miR-6757-5p as a breast cancer marker for the detection of breast cancer.

13. The use according to claim 12, wherein the miR-6757-5p is a polynucleotide shown in any one of the following (a) or (b): (a) A polynucleotide consisting of the base sequence represented by SEQ ID NO: 29, (b) A polynucleotide containing the base sequence represented by SEQ ID NO:

29.

14. The miR-6757-5p is miR-4783-3p, miR-1307-3p, miR-4634, miR-663a, miR-4532, miR-7704, miR-3178, miR-6729-5p, miR-6090, miR-4732-5p, miR-3184-5p, miR-6727-5p, miR-6088, miR-4674, miR-8073, miR-4787-5p, miR-1469, miR-125a-3p, miR-1233-5p, miR-885-3p, miR-6802-5p, miR-328-5p, miR-6787-5p, miR-8069, miR-6875-5p, miR-1246, miR-4734, miR-6756-5p, miR-3665, miR-6821-5p, miR-6805-5p, miR-4728-5p, miR-6726-5p, miR-197-5p, miR-149-3p, miR-6850-5p, miR-4476, miR-6858-5p, miR-564, miR-4763-3p, miR-575, miR-6771-5p, miR-1231, miR-1908-3p, miR-150-3p, miR-3937, miR-887-3p, miR-3940-5p, miR-4741, miR-6808-5p, miR-6869-5p, miR-5090, miR-615-5p, miR-8072, miR-128-1-5p, miR-1238-5p, miR-365a-5p, miR-204-3p, miR-4492, miR-6785-5p, miR-6511a-5p, miR-4525, miR-1915-5p, miR-3180, miR-6879-5p, miR-1199-5p, miR-6746-5p, miR-711, miR-663b, miR-4707-3p, miR-6893-5p, miR-4675, miR-4638-5p, miR-4651, miR-6087, miR-4665-5p, miR-4758-5p, miR-6887-5p, miR-3620-5p, miR-1909-3p, miR-7641, miR-6724-5p, miR-1343-3p, miR-6780b-5p, miR-4484, miR-4690-5p, miR-4429, miR-1227-5p, miR-4725-3p, miR-6861-5p, miR-6812-5p,miR-3197, miR-8059, miR-3185, miR-4706, miR-4497, miR-3131, miR-6806-5p, miR-187-5p, miR-3180-3p, miR-6848-5p, miR-6820-5p, miR-6800-5p, miR-6717-5p, miR-6795-5p, miR-4632-5p, miR-6778-5p, miR-3663-3p, miR-4689, miR-211-3p, miR-6511b-5p, miR-4750-5p, miR-6126, miR-614, miR-7110-5p, miR-744-5p, miR-6769a-5p, miR-4792, miR-5787, miR-6798-5p, miR-6781-5p, miR-4419b, miR-4446-3p, miR-4259, miR-5572, miR-6075, miR-296-3p, miR-6891-5p, miR-4745-5p, miR-6775-5p, miR-6870-5p, miR-920, miR-4530, miR-6819-5p, miR-6825-5p, miR-7847-3p, miR-6131, miR-4433-3p, miR-1228-5p, miR-6743-5p, miR-1268a, miR-3917, miR-6786-5p, miR-3154, miR-638, miR-6741-5p, miR-6889-5p, miR-6840-3p, miR-6510-5p, miR-3188, miR-551b-5p, miR-5001-5p, miR-1268b, miR-7107-5p, miR-6824-5p, miR-6732-5p, miR-371a-5p, miR-6794-5p, miR-6779-5p, miR-4271, miR-5195-3p, miR-6762-5p, miR-939-5p, miR-1247-3p, miR-6777-5p, miR-6722-3p, miR-3656, miR-4688, miR-3195, miR-6766-5p, miR-4447, miR-4656, miR-7108-5p, miR-3191-3p, miR-1273g-3p, miR-4463, miR-2861, miR-3196, miR-6877-5p, miR-3679-5p, miR-4442, miR-6789-5p, miR-6782-5pAt least one polynucleotide selected from the group consisting of miR-486-3p, miR-6085, miR-4746-3p, miR-619-5p, miR-937-5p, miR-6803-5p, miR-4298, miR-4454, miR-4459, miR-7150, miR-6880-5p, miR-4449, miR-8063, miR-4695-5p, miR-6132, miR-6829-5p, miR-4486, miR-6805-3p, miR-6826-5p, miR-4508, miR-1343-5p, miR-7114-5p, miR-3622a-5p, miR-6765-5p, miR-7845-5p, miR-3960, miR-6749-5p, miR-1260b, miR-6799-5p, miR-4723-5p, miR-6784-5p, miR-5100, miR-6769b-5p, miR-1207-5p, miR-642a-3p, miR-4505, miR-4270, miR-6721-5p, miR-7111-5p, miR-6791-5p, miR-7109-5p, miR-4258, miR-6515-3p, miR-6851-5p, miR-6125, miR-4749-5p, miR-4726-5p, miR-4513, miR-6089, miR-6816-5p, miR-4466, miR-4488, miR-6752-5p, miR-4739, miR-760, miR-602, miR-423-5p, miR-92a-2-5p, miR-16-5p, miR-451a, miR-135a-3p, miR-486-5p, miR-4257, miR-92b-5p, miR-1915-3p, miR-718, miR-940, miR-296-5p, miR-23b-3p, miR-92a-3p, miR-658, miR-6842-5p, miR-6124, miR-6765-3p, miR-7106-5p, miR-4534, miR-92b-3p, miR-3135b, miR-4687-3p, miR-762, miR-3619-3p, miR-4467, miR-557, miR-1237-5p, miR-1908-5p, miR-4286, miR-6885-5p, and miR-6763-5p, and used as a breast cancer marker for breast cancer detectionUse according to claim 12 or 13.

15. The use according to claim 14, wherein the at least one polynucleotide is at least one selected from the group consisting of the polynucleotides shown in any one of the following (c) and (d): (c) A polynucleotide consisting of a base sequence represented by any of SEQ ID NO: 1, 3 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269; (d) A polynucleotide containing a base sequence represented by any of SEQ ID NO: 1, 3 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269.

Images