Composition

Abstract

To provide a composition that contains organic acid, and when filled into a stamp container, offers superior dischargeability from the container and shape retentivity after discharged.SOLUTION: A composition contains the following components (A)-(C): (A) a polysaccharide having a main chain and a side chain in one repeat unit, wherein the number of monosaccharide units constituting a side chain in the repeat unit is 1.3 or more times greater than the number of monosaccharide units constituting the main chain; (B) an organic acid; and (C) a compound wherein some or all hydrogen atoms of a hydroxy group in a polysaccharide or a derivative thereof are substituted with the following substituent (1) and substituent (2). (1) a C12-36 linear or branched alkyl group or alkenyl group, which may have a hydroxy group or to which an ether bond may be inserted, and (2) a C1-5 sulfoalkyl group or a salt thereof, which may have a hydroxy group. The content of the component (A) is less than 1 mass%.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a composition. More specifically, it relates to a composition used by filling a pressing type container such as a stamp type container or a pump type container.

Background Art

[0002] An aqueous liquid composition having water as a main solvent is used as various external skin preparation compositions such as a disinfectant composition for skin and a skin cleansing composition. The active ingredient of the external skin preparation composition is selected according to the use. For example, in a bactericidal or antiviral agent composition for skin, it is known to use an organic acid as a component that realizes bactericidal or antiviral action. Patent Document 1 discloses a method for suppressing bacteria and viruses present on the skin surface of mammals, which includes contacting a compound or composition capable of reducing the skin pH to less than about 4 with the skin for at least about 0.5 hours. Examples of the compound or composition capable of reducing the skin pH include those containing organic acids such as monocarboxylic acids and polycarboxylic acids. Patent Document 2 discloses a method of applying a virus-killing composition (hand lotion) containing citric acid, malic acid, and C1-6 alcohol to the hands of a patient after being identified as having a rhinovirus cold or before being exposed to rhinovirus, to kill rhinovirus and prevent the spread of colds caused by rhinovirus.

[0003] Since the aqueous composition has a low viscosity as it is, for example, an aqueous external skin preparation composition is generally thickened by adding a thickening agent from the viewpoint of preventing dripping when applied to the skin. However, carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer, which are commonly used thickening agents in external skin preparation compositions, have a problem that the expected viscosity cannot be obtained in the presence of salts or under low pH conditions, or even if obtained, it varies over time. In order to solve such problems, Patent Document 3 discloses that a topical skin composition containing a carboxyvinyl polymer or an alkyl-modified carboxyvinyl polymer, a non-vegetable polysaccharide thickener, and at least one selected from the group consisting of hydroxymonocarboxylic acid, hydroxydicarboxylic acid, and phytic acid (however, in the case of lactic acid, it is 0.1 to 20% by weight), that is, a composition in which a non-vegetable polysaccharide thickener is blended with a carboxyvinyl polymer or an alkyl-modified carboxyvinyl polymer, can achieve a stable viscosity even in a low pH region.

[0004] By the way, it is also known to use a liquid composition by accommodating it in a container such as a stamp-type container or a pump container (Patent Document 4). A stamp-type container is a kind of pressing-type container. For example, it has a container part having a housing part for accommodating a liquid composition and one or more discharge ports capable of discharging the liquid composition into a desired pattern shape by a single pressing operation, and a pressing mechanism for pushing out the liquid composition accommodated in the housing part in the direction of the discharge port.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Summary of the Invention

Problems to be Solved by the Invention

[0006] In compositions used by being discharged from a pressing-type container such as a stamp-type container or a pump-type container, since the viscosity range capable of ensuring sufficient dischargeability is limited, there is also a problem that the degree of freedom in formulation is low. Further, in the composition filled in the stamp-type container and used, in addition to the dischargeability from the stamp-type container, a shape-retaining property capable of maintaining the shape for a certain period of time after discharge is required. However, no composition has been found that can achieve both the dischargeability from the stamp-type container and the shape-retaining property after discharge.

[0007] The present invention relates to a composition containing an organic acid, and particularly excellent in dischargeability from a container and shape-retaining property after discharge when filled in a stamp-type container. [Means for Solving the Problems]

[0008] The present inventors have found that the above problems can be solved by using two types of polysaccharides having specific structures as thickening polymers in a composition containing an organic acid. That is, the present invention provides the following [1] and [2]. [1] The following components (A) to (C): (A) A polysaccharide having a main chain and a side chain in one repeating unit, wherein the number of monosaccharide units constituting the side chain in the repeating unit is 1.3 times or more the number of monosaccharide units constituting the main chain (B) An organic acid (C) A compound in which some or all of the hydrogen atoms of the hydroxy groups in a polysaccharide or its derivative are substituted with the following substituent (1) and substituent (2) (1) A linear or branched alkyl group or alkenyl group having 12 to 36 carbon atoms, which may have a hydroxy group and may have an ether bond inserted therein (2) A sulfoalkyl group having 1 to 5 carbon atoms or a salt thereof, which may have a hydroxy group containing a composition in which the content of component (A) is less than 1% by mass. [2] A stamp preparation obtained by filling the composition according to [1] above into a stamp-type container. [Effects of the Invention]

[0009] According to the present invention, there can be provided a composition containing an organic acid, which is excellent in dischargeability from a container and shape retention after discharge, particularly when filled in a stamp-type container. The composition is useful, for example, as a bactericidal topical composition for skin using an organic acid such as lactic acid as a bactericidal component.

Brief Description of the Drawings

[0010]

Figure 1

Figure 2

Figure 3

Figure 4

Modes for Carrying Out the Invention

[0011] [Composition] The composition of the present invention contains the following components (A) to (C): (A) A polysaccharide having a main chain and a side chain in one repeating unit, wherein the number of monosaccharide units constituting the side chain in the repeating unit is 1.3 times or more the number of monosaccharide units constituting the main chain (B) An organic acid (C) A compound in which some or all of the hydrogen atoms of the hydroxy groups in a polysaccharide or a derivative thereof are substituted with the following substituents (1) and (2) (1) A linear or branched alkyl group or alkenyl group having 12 to 36 carbon atoms, which may have a hydroxy group and may have an ether bond inserted therein (2) A sulfoalkyl group having 1 to 5 carbon atoms or a salt thereof, which may have a hydroxy group and is a composition in which the content of component (A) is less than 1% by mass. Due to having the above configuration, the composition of the present invention, even if it is a composition containing an organic acid, when filled in a stamp-type container and used, has excellent dischargeability from the container and shape retention after discharge. Hereinafter, the dischargeability and shape retention after discharge of the composition from a pressing-type container such as a stamp-type container or a pump-type container are also simply referred to as "dischargeability and shape retention".

[0012] In this specification, the "composition containing X and Y" shall also include the composition in which X and Y are blended.

[0013] Although the reason why the composition of the present invention exhibits the above effects is not clear, it is considered as follows. The composition used by discharging from a pressing-type container such as a stamp-type container or a pump-type container needs to have a low viscosity when discharged from the container in order to have good dischargeability. On the other hand, in order to have good shape retention after discharge of the composition, the composition after discharge needs to have a high viscosity. Therefore, the composition must have completely different viscosities under each shear rate at the time of discharge and at the time of shape retention. That is, a shear thinning property in which the viscosity changes rapidly according to the shear rate is required. The composition of the present invention contains component (A) and component (C) as thickening polymers, and it is considered that by containing component (A), high shear thinning property is realized. Component (A) is a polysaccharide having a main chain and a side chain in one repeating unit, and the number of monosaccharide units constituting the side chain is 1.3 times or more the number of monosaccharide units constituting the main chain. Since component (A) has a long side chain with respect to the main chain and has a rigid structure, it is considered that the composition containing component (A) can easily have its structure destroyed immediately when sheared, and high shear thinning property can be realized.

[0014] As described above, carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers, which are thickeners commonly used in aqueous compositions, have a problem in that it is difficult to obtain a thickening effect under low pH conditions. This is because the carboxy groups in the thickener are neutralized by a base in the composition, and the thickening effect is exhibited by the repulsion between the resulting negative charges. However, under acidic conditions, negative charges do not occur and it is difficult to thicken. Further, in a system where a large amount of salt is present, the above thickener tends to be difficult to thicken because the negative charge portion is shielded by the electrostatic shielding action. On the other hand, since component (A) has a rigid structure having a main chain and a side chain, it is considered that it spreads easily without shrinking even in the presence of a salt or an acid, and the thickening effect is not impaired. Further, in component (C), some or all of the hydrogen atoms of the hydroxy groups in the polysaccharide or its derivative are (1) a linear or branched alkyl group or alkenyl group having 12 or more and 36 or less carbon atoms, which may have a hydroxy group and may have an ether bond inserted therein, and (2) a sulfoalkyl group having 1 or more and 5 or less carbon atoms or a compound substituted with a salt thereof, which may have a hydroxy group. That is, component (C) is a polysaccharide derivative or a salt thereof having a hydrophobic group according to the above (1) and a sulfonic acid group derived from the above (2). When component (C) has a hydrophobic group according to the above (1), it is considered that a thickening effect due to hydrophobic interaction is easily obtained in the composition. Further, since the sulfonic acid group has a low pKa, component (C) which is a sulfonic acid or a sulfonate retains a negative charge even in a low pH system containing an organic acid, and it is considered that a thickening effect is obtained by the charge repulsion. As described above, the composition of the present invention uses component (A) and component (C) as thickening polymers, so that a thickening effect can be obtained even in a composition containing an organic acid as component (B) as an active ingredient, and further, the dischargeability from a pressing type container and the shape retention after discharge are considered to be improved.

[0015] The composition of the present invention is used, for example, as a composition for external use on the skin or a cosmetic composition. Since the composition of the present invention contains an organic acid as component (B), among skin external use compositions, it is preferably a bactericidal skin external use composition containing an organic acid such as lactic acid as a bactericidal component.

[0016] <Component (A): Polysaccharide> The composition of the present invention contains, as component (A), a polysaccharide having a main chain and a side chain in one repeating unit, and the number of monosaccharide units constituting the side chain in the repeating unit is 1.3 times or more the number of monosaccharide units constituting the main chain. By containing component (A), the composition of the present invention can impart shear thinning properties, and it is considered that the dischargeability from a pressing container and the shape retention property after discharge are improved. The "one repeating unit" in component (A) means a repeating unit composed of a plurality of monosaccharide units that constitute the polysaccharide. The "one repeating unit" in component (A) is a repeating unit having a main chain and a side chain, and the number of monosaccharide units constituting the side chain in the repeating unit is 1.3 times or more the number of monosaccharide units constituting the main chain. From the viewpoint of achieving both the dischargeability and the shape retention property of the composition, the number of monosaccharide units constituting the side chain in the repeating unit of component (A) is preferably 1.3 times or more, more preferably 1.4 times or more, relative to the number of monosaccharide units constituting the main chain, and is preferably 2.5 times or less, more preferably 2.0 times or less, still more preferably 1.8 times or less.

[0017] In the repeating unit of component (A), examples of the monosaccharide unit constituting the main chain include one or more selected from the group consisting of a glucose unit, a fructose unit, a galactose unit, and a mannose unit. Among these, the monosaccharide unit constituting the main chain is preferably a glucose unit.

[0018] In the repeating unit of component (A), examples of the monosaccharide unit constituting the side chain include one or more selected from the group consisting of a glucose unit, a fructose unit, a galactose unit, a mannose unit, and a glucuronic acid unit. Among these, the monosaccharide unit constituting the main chain is preferably one or more selected from the group consisting of a mannose unit and a glucuronic acid unit, more preferably a mannose unit and a glucuronic acid unit.

[0019] Component (A) is preferably xanthan gum from the viewpoint of achieving both the ejection property and the shape retention property of the composition. The repeating unit of xanthan gum is composed of two glucose units in the main chain, two mannose units and one glucuronic acid unit in the side chain. Examples of commercially available xanthan gums include "Echogum" manufactured by DSP Gokyo Foods & Chemicals Co., Ltd., "Keltrol" manufactured by CP Kelco, "Sun Ace C" manufactured by San-Ei Gen F.F.I., Inc., and "Nomucote ZZ" manufactured by Nisshin OilliO Group, Ltd.

[0020] <Component (B): Organic acid> The composition of the present invention contains an organic acid as component (B). Component (B) acts as a bactericidal component in a bactericidal topical skin preparation composition. In other topical skin preparation compositions and cosmetic compositions, component (B) also acts as a pH adjuster, a modifier, and the like.

[0021] Among component (B), as the organic acid used as a bactericidal component, from the viewpoints of bactericidal property and high safety because it is originally present in human skin and can reduce skin irritation, one or more organic acids selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid (hereinafter also referred to as "component (B1)") are preferable. Among these, from the viewpoint of improving bactericidal property, lactic acid is more preferable. When component (B) contains component (B1), the content of (B1) in the total amount of component (B) is preferably 50% by mass or more, more preferably 70% by mass or more, still more preferably 80% by mass or more, even more preferably 90% by mass or more, and 100% by mass or less from the viewpoint of improving bactericidal property. When component (B1) contains lactic acid, the content of lactic acid in the total amount of component (B1) is preferably 50% by mass or more, more preferably 70% by mass or more, still more preferably 80% by mass or more, even more preferably 90% by mass or more, and 100% by mass or less, from the viewpoint of improving bactericidal properties. Examples of commercially available lactic acid include "Musashino Lactic Acid 90F" manufactured by Musashino Chemical Laboratory, Ltd.

[0022] From the viewpoints of adjusting the pH of the composition, further improving bactericidal properties by using in combination with component (B1), and easily maintaining the pH of the composition constant by a buffering action, as component (B), an organic acid other than component (B1) (hereinafter also referred to as "component (B2)") can also be used. As component (B2), from the viewpoint of use in a composition for external use on the skin or a cosmetic composition, it is preferably at least one selected from the group consisting of ascorbic acid and carboxylic acid compounds, more preferably a carboxylic acid compound. Also, from the viewpoint of water solubility, component (B2) is preferably an organic acid having 8 or less carbon atoms, more preferably 6 or less carbon atoms.

[0023] Specific examples of component (B2) include ascorbic acid; hydroxycarboxylic acids such as gluconic acid, citric acid, malic acid, and tartaric acid; polycarboxylic acids having no hydroxy group such as fumaric acid, succinic acid, and adipic acid; etc. These can be used alone or in combination of two or more. Among these, from the viewpoints of adjusting the pH of the composition, further improving bactericidal properties by using in combination with component (B1), and easily maintaining the pH of the composition constant by a buffering action, it is preferably at least one selected from the group consisting of hydroxycarboxylic acids and polycarboxylic acids having no hydroxy group, more preferably a polycarboxylic acid having no hydroxy group, still more preferably at least one selected from the group consisting of fumaric acid, succinic acid, and adipic acid, and even more preferably succinic acid.

[0024] Component (B) may be blended in the form of an organic acid salt. Specific examples of the organic acid salt include alkali metal salts such as potassium salts and sodium salts; alkaline earth metal salts such as calcium salts and magnesium salts; amine salts; ammonium salts and the like. Among these, one or more selected from the group consisting of alkali metal salts and alkaline earth metal salts are preferred, and one or more selected from the group consisting of potassium salts, sodium salts, and calcium salts are more preferred.

[0025] <Component (C)> The composition of the present invention contains, as component (C), a compound in which part or all of the hydrogen atoms of the hydroxy groups of a polysaccharide or a derivative thereof are substituted with the following substituent (1) and substituent (2). (1) A linear or branched alkyl group or alkenyl group having 12 to 36 carbon atoms, which may have a hydroxy group and may have an ether bond inserted therein (2) A sulfoalkyl group having 1 to 5 carbon atoms or a salt thereof, which may have a hydroxy group Component (C) acts as a thickener together with component (A) and contributes to the improvement of the dischargeability and shape retention of the composition.

[0026] Examples of the polysaccharide or its derivative in component (C) include cellulose, guar gum, starch, or derivatives thereof. The "derivatives" mentioned here include alkylated products and hydroxyalkylated products of polysaccharides. The number of carbon atoms of the alkyl group in the alkylated product and hydroxyalkylated product is preferably 1 or more and 6 or less, more preferably 1 or more and 4 or less, and still more preferably 1 or more and 3 or less, from the viewpoints of water solubility and reactivity when introducing substituent (1) and (2).

[0027] Specific examples of the polysaccharide or its derivative in component (C) include one or more selected from the group consisting of cellulose, guar gum, starch, hydroxyethyl cellulose, hydroxyethyl guar gum, hydroxyethyl starch, methyl cellulose, methyl guar gum, methyl starch, ethyl cellulose, ethyl guar gum, ethyl starch, hydroxypropyl cellulose, hydroxypropyl guar gum, hydroxypropyl starch, hydroxyethyl methyl cellulose, hydroxyethyl methyl guar gum, hydroxyethyl methyl starch, hydroxypropyl methyl cellulose, hydroxypropyl methyl guar gum, and hydroxypropyl methyl starch. Among these, from the viewpoint of improving the dischargeability and shape retention of the composition, it is preferably cellulose or its derivative, more preferably a cellulose derivative, still more preferably one or more selected from the group consisting of hydroxyethyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methyl cellulose, even more preferably one or more selected from the group consisting of hydroxyethyl cellulose and hydroxypropyl cellulose, and even more preferably hydroxyethyl cellulose.

[0028] Component (C) is a compound in which some or all of the hydrogen atoms of the hydroxy groups in the polysaccharide or its derivative are substituted with the substituent (1) and the substituent (2). When the derivative of the polysaccharide is a hydroxyalkylated product of the polysaccharide, the hydrogen atom of the hydroxy group substituted with the substituent (1) and the substituent (2) may be the hydrogen atom of the hydroxyalkyl group. The substituent (1) is a linear or branched alkyl group or alkenyl group having 12 to 36 carbon atoms, which may have a hydroxy group and may have an ether bond inserted therein. From the viewpoint of improving the dischargeability and shape retention of the composition, the substituent (1) is preferably a linear or branched alkyl group having 12 to 36 carbon atoms, or -CH2CH(OH)CH2OR 1 (R 1 is a linear or branched alkyl group having 9 to 33 carbon atoms.) and is a group represented by. When the substituent (1) is a linear or branched alkyl group having 12 to 36 carbon atoms, the number of carbon atoms is more preferably 12 to 30, still more preferably 14 to 26, and even more preferably 16 to 22. When the substituent (1) is a group represented by -CH2CH(OH)CH2OR 1 for R 1 the number of carbon atoms is more preferably 10 to 30, still more preferably 12 to 26, and even more preferably 14 to 22.

[0029] From the viewpoint of improving the dischargeability and shape retention of the composition, the substituent (1) is even more preferably a group represented by -CH2CH(OH)CH2OC 18 H 37

[0030] From the viewpoint of improving the dischargeability and shape retention of the composition, the molar substitution degree of the substituent (1) in the component (C) is preferably 0.0001 or more, more preferably 0.001 or more, and from the viewpoint of improving water solubility, it is preferably 1.0 or less, more preferably 0.1 or less, and still more preferably 0.01 or less. The molar substitution degree of the substituent (1) in the component (C) means the introduced molar amount of the substituent (1) per mole of the monosaccharide unit constituting the component (C), 1 and can be measured by 1H-NMR.

[0031] The substituent (2) is a sulfoalkyl group having 1 to 5 carbon atoms or a salt thereof which may have a hydroxy group. The number of carbon atoms of the sulfoalkyl group is preferably 2 to 5, more preferably 2 to 4. Examples of the salt of the sulfoalkyl group in the substituent (2) include alkali metal salts such as potassium salt and sodium salt; alkaline earth metal salts such as calcium salt and magnesium salt; amine salts; ammonium salts and the like. Among these, from the viewpoint of availability, an alkali metal salt is preferred, and a sodium salt is more preferred. From the viewpoint of improving the dischargeability and shape retention of the composition, the substituent (2) is more preferably -CH2CH(OH)CH2SO3 - M​+ (M is a hydrogen atom or Na.)

[0032] From the viewpoint of improving water solubility, the molar substitution degree of the substituent (2) in component (C) is preferably 0.01 or more, more preferably 0.1 or more, still more preferably 0.15 or more. From the viewpoints of improving the dischargeability and shape retention of the composition, it is preferably 2.0 or less, more preferably 0.5 or less, still more preferably 0.3 or less. The molar substitution degree of the substituent (2) in component (C) means the introduced molar amount of the substituent (2) per mole of the monosaccharide unit constituting component (C), 1 which can be measured by 1H-NMR.

[0033] Examples of commercially available products of component (C) include "POIZ 310" (sodium stearoxy PG-hydroxyethyl cellulose sulfonate) manufactured by Kao Corporation.

[0034] <Content> From the viewpoints of improving dischargeability and shape retention, etc., the content of each component in the composition of the present invention is preferably in the following ranges.

[0035] From the viewpoint of improving shape retention, the content of component (A) in the composition is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, still more preferably 0.1% by mass or more. From the viewpoint of improving dischargeability, it is less than 1% by mass, preferably 0.8% by mass or less, more preferably 0.7% by mass or less, still more preferably 0.5% by mass or less.

[0036] From the viewpoints of pH adjustment ability and improving bactericidal properties when used as a bactericidal skin external preparation composition, the content of component (B) in the composition is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, still more preferably 0.5% by mass or more. From the viewpoint of suppressing skin irritation, it is preferably 10% by mass or less, more preferably 5% by mass or less, still more preferably 3% by mass or less, even more preferably 2% by mass or less.

[0037] When component (B) contains one or more organic acids (component (B1)) selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid, the content of component (B1) in the composition is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, still more preferably 0.2% by mass or more, and even more preferably 0.5% by mass or more from the viewpoint of improving bactericidal properties when used as a bactericidal topical skin composition. Also, from the viewpoint of suppressing skin irritation, it is preferably 5% by mass or less, more preferably 3% by mass or less, still more preferably 2% by mass or less, and even more preferably 1.5% by mass or less.

[0038] When component (B) contains an organic acid other than component (B1) (component (B2)), the content of component (B2) in the composition is preferably 0.05% by mass or more, more preferably 0.2% by mass or more, and still more preferably 0.5% by mass or more from the viewpoint of pH adjustment ability. Also, from the viewpoint of suppressing skin irritation, it is preferably 5% by mass or less, more preferably 3% by mass or less, still more preferably 2% by mass or less, even more preferably 1% by mass or less, and even more preferably 0.5% by mass or less.

[0039] In the present specification, when an organic acid salt is blended as component (B), the "content of component (B)" means the amount converted to an organic acid.

[0040] The content of component (C) in the composition is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, and still more preferably 0.5% by mass or more from the viewpoint of improving shape retention. Also, from the viewpoint of improving ejectability, it is preferably 3% by mass or less, more preferably 2% by mass or less, and still more preferably 1% by mass or less.

[0041] From the viewpoint of improving ejection property and shape retention property, the ratio of the content of component (A) to the content of component (C) in the composition is preferably 0.05 or more, more preferably 0.08 or more, still more preferably 0.1 or more, even more preferably 0.2 or more, even more preferably 0.3 or more, and preferably 2.0 or less, more preferably 1.5 or less, still more preferably 1.0 or less, even more preferably 0.8 or less, even more preferably 0.5 or less, in terms of mass ratio [(A) / (C)].

[0042] From the viewpoint of obtaining the effects of the present invention, the total content of components (A) to (C) in the composition is preferably 0.3% by mass or more, more preferably 0.5% by mass or more, still more preferably 1% by mass or more, even more preferably 1.5% by mass or more. Also, from the viewpoint of improving ejection property, it is preferably less than 9% by mass, more preferably 6% by mass or less, still more preferably 4% by mass or less, even more preferably 3% by mass or less.

[0043] <Water> From the viewpoints of dissolving components (A) to (C) and improving ejection property, the composition of the present invention preferably further contains water. The water content in the composition is preferably 50% by mass or more, more preferably 70% by mass or more, and preferably 99.8% by mass or less, more preferably 99% by mass or less.

[0044] In addition to the above, the composition of the present invention may contain other components as needed, for example, surfactants, pH adjusters other than component (B), oil agents, ultraviolet absorbers, antioxidants, preservatives, antiperspirants, fragrances, moisturizers, touch adjusters, anti-inflammatory agents, etc.

[0045] <Viscosity> The composition of the present invention has high shear thinning properties. Specifically, the viscosity measured by the shear rate dependence of the composition is preferably 300 Pa·s or more at a shear rate of 0.005 (1 / s) and 3.0 Pa·s or less at a shear rate of 20 (1 / s) at 25°C, more preferably 350 Pa·s or more at a shear rate of 0.005 (1 / s) and 2.0 Pa·s or less at a shear rate of 20 (1 / s), and even more preferably 500 Pa·s or more at a shear rate of 0.005 (1 / s) and 2.0 Pa·s or less at a shear rate of 20 (1 / s). The viscosity of the composition can be measured with a rheometer, specifically, it can be measured by the method described in the examples.

[0046] <ph> From the viewpoint of suppressing skin irritation, the pH of the composition of the present invention is preferably 3.5 or higher, more preferably 3.7 or higher. Further, from the viewpoint of improving bactericidal properties when the composition is used as a bactericidal or virucidal topical skin composition, it is preferably 5.0 or lower, more preferably 4.5 or lower. The above pH is the value at 25 °C and can be measured using a pH meter.

[0047] The composition of the present invention may be in the form of an emulsion composition such as an oil-in-water emulsion composition or a water-in-oil emulsion composition.

[0048] <Method for producing the composition> The method for producing the composition of the present invention is not particularly limited, but from the viewpoint of improving productivity, it is preferably produced by the following method. First, water is heated to a temperature of 70 °C or higher and lower than 100 °C, and then component (A) and component (C) are added and stirred to dissolve them. The temperature of the water is preferably 80 to 90 °C from the viewpoint of the solubility of component (A) and component (C). The order of adding component (A) and component (C) to water is not particularly limited, and component (A) and component (C) may be added simultaneously or separately. The amount of water for dissolving component (A) and component (C) may be at least a part of the water contained in the finally obtained composition. The stirring time may be the time for component (A) and component (C) to dissolve, and from the viewpoints of the solubility of component (A) and component (C) and productivity, it is preferably 0.5 to 12 hours, more preferably 1 to 6 hours.

[0049] Next, the aqueous solution obtained by dissolving component (A) and component (C) is preferably cooled to a temperature of 40 °C or lower. The cooling rate of the aqueous solution is preferably faster, for example, the cooling rate is 1.5 °C / min or higher, preferably 3.0 °C / min or higher. After cooling, while maintaining the aqueous solution at a temperature of 40 °C or lower, an aqueous solution of component (B) is added and stirred. The stirring time is not particularly limited, but from the viewpoint of productivity, it is preferably 5 minutes to 6 hours, more preferably 5 minutes to 3 hours. Defoam the aqueous solution obtained as described above to obtain the composition of the present invention containing components (A) to (C). Optional components other than components (A) to (C) may be added at any timing.

[0050] <Use of the composition> The composition of the present invention is used as a composition for external use on the skin and a cosmetic composition. Since the composition of the present invention contains the organic acid which is component (B), among the compositions for external use on the skin, it is preferably a bactericidal composition for external use on the skin in which the organic acid (particularly component (B1)) is blended as a bactericidal component. Further, from the viewpoint of preventing contact infection by bacteria, it is more preferably a composition for external use on the skin for fingers. Examples of its product form include finger disinfectants and hand lotions. Examples of the cosmetic composition include a moisturizing composition, an antiperspirant composition, a sunscreen composition, and the like.

[0051] The composition of the present invention is preferably a leave-on composition. The "leave-on composition" means a composition that is used without being removed by washing with water or the like after being applied to an object such as the skin. For example, in the bactericidal composition for external use on the skin, by leaving component (B), which is the bactericidal component, on the skin surface, a bactericidal effect can be imparted to the skin surface. From the viewpoint of obtaining this effect, after the composition of the present invention is applied to the skin by coating or the like, the composition is not removed by washing with water or the like and is left on the skin surface for use. From the viewpoint of preventing contact infection by bacteria, the composition of the present invention is more preferably a leave-on composition for external use on the skin for fingers.

[0052] The bacteria that are the targets for expressing bactericidal properties are not particularly limited as long as they are inactivated or killed by contact with an acid, and for example, it is considered applicable to the microorganisms described in the Guidelines for Infection Control in Nurseries of the Ministry of Health, Labour and Welfare. Specifically, examples of the bacteria include Gram-positive bacteria such as Bacillus anthracis, Mycobacterium tuberculosis, Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumoniae, etc., or Gram-negative bacteria such as Francisella tularensis, Yersinia pestis, Brucella spp., Burkholderia mallei, Vibrio cholerae, Salmonella spp., Shigella spp., Enterohemorrhagic Escherichia coli, Bordetella pertussis, etc.

[0053] <Usage form of the composition> Since the composition of the present invention is excellent in dischargeability from a pressing container such as a stamp-type container or a pump-type container and shape retention after discharge, it is preferably filled in a pressing container and discharged from the container for use. Among them, it is preferable to fill the composition of the present invention in a stamp-type container and use it as a stamp preparation.

[0054] <Application method of the composition> The method of applying the composition to the object can be appropriately selected according to the dosage form, application site, etc. For example, when the composition of the present invention is a composition for external use on the skin, the composition is filled in a pressing container such as a stamp-type container or a pump-type container, discharged from the container, and applied to the skin surface. It is preferable that the composition is not removed by washing with water or the like after being applied to the skin and remains on the skin surface. In the bactericidal composition for external use on the skin, by leaving the component (B) which is a bactericidal component on the skin surface, a bactericidal effect can be imparted to the skin surface.

[0055] The bactericidal composition for external use on the skin may be applied to the skin that has been previously washed with water, soap, body soap, hand soap, etc., or may be applied to unwashed skin. Since components such as lactic acid present on the natural skin surface are washed away from the washed skin and the defensive power against bacteria present in the external environment is reduced, it is more preferable to apply the composition to the washed skin.

[0056] [Stamp preparation] The stamp preparation of the present invention is obtained by filling the above composition in a stamp-type container. The stamp-type container used for the stamp preparation is a container comprising a container part having a storage part for storing a composition and one or two or more discharge ports capable of discharging the composition into a desired pattern shape by a single pressing operation, and a pressing mechanism for pushing out the composition stored in the storage part in the direction of the discharge port, and a known container can be used.

[0057] An embodiment of the stamp-type container will be described with reference to the drawings. FIG. 1 is a schematic view showing a stamp-type container 100, and FIG. 2 is a schematic view showing the constituent members of the stamp-type container 100. FIG. 3 is a schematic view showing an embodiment of the usage method of the stamp preparation. FIG. 4 is a photograph of the shape of the composition discharged from the stamp-type container 100. The stamp-type container 100 in FIG. 1 is composed of a delami bottle 1, a pump 2, a shoulder cover 3, a base 4, a nozzle part 5, and an overcap 6 shown in FIG. 2. The nozzle part 5 has one or two or more discharge ports. After filling the composition into the delami bottle 1 and setting it in the stamp-type container 100, the user holds the delami bottle 1 part with one hand and pushes the delami bottle 1 in the direction of the arrow in FIG. 3 with the opening of the overcap 6 gently applied to the surface of the object. Thereby, the pump 2 is driven, and the composition in the delami bottle 1 is absorbed into the pump. Next, the composition passes through the base 4 and the nozzle part 5 and is discharged from the discharge port and supplied to the object. For example, when the nozzle part 5 of the stamp-type container 100 has five circular discharge ports arranged at equal intervals along the circumferential direction of the nozzle part 5, as shown in FIG. 4, it is preferable that there is no variation in the amount of the composition discharged from each discharge port, and the compositions discharged from different discharge ports maintain their independent shapes without merging. In this state, it can be regarded that the shape retention property is good.

Example

[0058] Hereinafter, the present invention will be described by way of examples, but the present invention is not limited to the scope of the examples. In this example, various measurements and evaluations were performed by the following methods.

[0059] <ph> The pH of the composition obtained in each example was measured at 25°C using a pH meter (HORIBA "F-53").

[0060] <Viscosity> The viscosity of the composition obtained in each example was measured at 25°C using a rheometer (Anton Paar "MCR302"). In the shear rate dependency measurement, after changing the shear rate from 0.005 to 5,000 (1 / s), it was decelerated again to 0.005 (1 / s). The viscosity at that time was recorded at 38 points, and the viscosities at shear rates of 0.005 (1 / s) and 20 (1 / s) are shown in Table 1.

[0061] <Extrudability, Shape Retention> Stamp-type preparations were prepared by accommodating the composition obtained in each example in a stamp-type container 100 having the shape shown in FIG. 1. Specifically, after filling about 30 g of the composition into the delami bottle 1 provided in the stamp-type container 100, a pump 2, a shoulder cover 3, a base 4, a nozzle portion 5 having five discharge ports, and an overcap 6 were sequentially set at the opening of the delami bottle 1 to assemble the stamp-type container 100. The outer diameter of the used stamp-type container (manufactured by Kao Corporation) is cylindrical with a diameter of 45 mm and a length of 140 mm, and the capacity of the delami bottle 1 is about 43 mL. Further, the diameter of the discharge port provided in the nozzle portion 5 is 1.5 mm, and the interval between adjacent discharge ports is 6 mm. Next, the subject held the delami bottle 1 part with one hand so that the longitudinal direction of the stamp-type container 100 was perpendicular to the ground, and pushed the delami bottle 1 once in the direction of the arrow in FIG. 3 with the opening of the overcap 6 gently applied to the palm of the other hand to discharge the composition. The shape of the composition after discharge was visually observed, and the extrudability and shape retention were evaluated according to the following criteria.

[0062] 〔Evaluation Criteria for Extrudability〕 5: The compositions discharged from all discharge ports are equal in amount, and the discharge is smooth 4: The compositions discharged from all discharge ports are equal in amount, but the composition after discharge has slightly sharp corners 3: The composition is discharged from all the discharge ports, but the discharge amounts are not equal. 2: The composition clogs in some of the discharge ports and is not discharged. 1: The composition clogs and is not discharged at all. 〔Evaluation criteria for shape retention〕 5: Even if the palm on which the composition is discharged is tilted vertically for 5 seconds, the shape of the composition after discharge is maintained, and the compositions discharged from different discharge ports do not merge with each other. 4: When the palm on which the composition is discharged is tilted vertically for 5 seconds, the compositions discharged from different discharge ports merge with each other, but they do not merge even after 5 seconds when the palm on which the composition is discharged is facing upward. 3: The compositions discharged from different discharge ports do not merge immediately after the composition is discharged onto the palm (within 1 second), but they merge within 5 seconds when the palm on which the composition is discharged is placed stationary with the palm facing upward. 2: The compositions discharged from different discharge ports merge immediately after the composition is discharged onto the palm (within 1 second), but the traces of discharge from the five discharge ports remain. 1: The composition merges immediately after being discharged onto the palm (within 1 second) and becomes a single liquid pool.

[0063] Examples 1 to 5, Comparative Examples 1 to 3 (Preparation and evaluation of the composition) Each component shown in Table 1 was used at the blending ratio described in the table, and the composition was prepared according to the following procedure. First, lactic acid as component (B) was dissolved in ion-exchanged water, and further an aqueous sodium hydroxide solution was added to adjust the pH to prepare an 11% lactic acid aqueous solution with a pH of 4.0. Next, the remaining ion-exchanged water was put into a beaker and heated while stirring at a stirring speed of 300 rpm. After the internal temperature reached 85°C, in Examples 1 to 5 and Comparative Example 2, component (A) was added and stirred for 10 minutes. Next, component (C) or component (C’) was added and stirred for 90 minutes, then the beaker was transferred to an ice bath and further stirred for 60 minutes to cool. The lactic acid aqueous solution, preservative, and humectant were added thereto and stirred for 10 minutes, then a feel modifier was added, and the mixture was stirred at 8000 rpm for 5 minutes using a homogenizer. Thereafter, defoaming was carried out by centrifugation to obtain a liquid aqueous composition. Table 1 shows the results of various evaluations performed by the above method using the obtained composition. Note that the compounding amounts (mass %) described in the table are all amounts of active ingredients. Also, a component that is a cellulose derivative and does not correspond to component (C) is denoted as “component (C’)” in this example.

[0064]

Table 1

[0065] The components described in the table are as follows. Component (A) Xanthan gum: “Kelcide” manufactured by CP Kelco Component (B) Lactic acid: “Musashino Lactic Acid 90F” manufactured by Musashino Chemical Laboratory, Ltd. Component (C) Sodium stearoxy PG-hydroxyethyl cellulose sulfonate: “POIZ 310” manufactured by Kao Corporation, -CH2CH2OCH2CH(OH)CH2OC 18 H 37 with a molar substitution degree of = 0.003, -CH2CH2CH(OH)CH2SO3 - Na + with a molar substitution degree of = 0.2 Component (C’) Hydroxyethyl cellulose: “Natrosol 250HHX” manufactured by Ashland ※1 Preservative: Methyl paraben, “Mekins-M” manufactured by Ueno Pharmaceutical Co., Ltd. ※2 Humectant: A mixture of PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, “WILBRIDE S-753” manufactured by NOF Corporation, and “Cosmetic Grade Concentrated Glycerin” manufactured by Kao Corporation ※3 Sensitivity adjuster: A mixture of diphenylsiloxyphenyltrimethicone (Shin-Etsu Chemical Co., Ltd. "KF-56A") and (dimethylsilicone / vinyl dimethicone) copolymer (Shin-Etsu Chemical Co., Ltd. "KSG-16")

[0066] From Table 1, it can be seen that when the composition of the present invention is filled and used in a stamp-type container, it is excellent in dischargeability from the container and shape retention after discharge. On the other hand, in Comparative Examples 1 and 3 that do not contain component (A), and in the compositions of Comparative Example 2 that use hydroxyethyl cellulose in place of component (C), none of them could achieve both good dischargeability and shape retention.

Industrial Applicability

[0067] According to the present invention, it is possible to provide a composition that contains an organic acid and is particularly excellent in dischargeability from a stamp-type container and shape retention after discharge when filled and used in the container. The composition is useful as a bactericidal topical skin preparation composition that uses an organic acid such as lactic acid as a bactericidal component.

Explanation of Symbols

[0068] 100 Stamp-type container 1 Delamibottle 2 Pump 3 Shoulder cover 4 Base 5 Nozzle part 6 Overcap< / ph> < / ph>

Claims

1. The following components (A) to (C): (A) Xanthan gum (B) Organic acid (C) Hydroxyethyl cellulose in which some or all of the hydrogen atoms of the hydroxy groups are substituted with the following substituent (1) and substituent (2) (1) A linear or branched alkyl group or alkenyl group having 16 to 26 carbon atoms, which may have a hydroxy group and may have an ether bond inserted therein (2) A sulfoalkyl group having 2 to 5 carbon atoms or a salt thereof, which may have a hydroxy group containing The molar substitution degree of substituent (1) is 0.001 or more and 0.01 or less, The molar substitution degree of substituent (2) is 0.1 or more and 0.5 or less, The content of component (A) is 0.05% by mass or more and less than 1% by mass, The pH at 25 °C is 3.5 or more and 5.0 or less, A composition for stamp preparations.

2. The composition according to claim 1, wherein component (B) contains lactic acid.

3. The composition according to claim 1 or 2, further containing water.

4. The viscosity of the composition measured by shear rate dependence is 300 Pa·s or more at a shear rate of 0.005 (1 / s) and 3.0 Pa·s or less at a shear rate of 20 (1 / s) at 25 °C. The composition according to any one of claims 1 to 3.

5. The ratio of the content of component (A) to the content of component (C) in the composition is 0.05 or more and 2.0 or less as the mass ratio [(A) / (C)]. The composition according to any one of claims 1 to 4.

6. The composition according to any one of claims 1 to 5, which is a bactericidal topical skin preparation composition.

7. A stamp preparation obtained by filling a stamp-type container with the composition according to any one of claims 1 to 6.

Images