Composition for improving skin barrier function after washing

Abstract

To provide a composition for improving skin barrier function after washing which is excellent in the improvement effect of skin barrier function, has low skin irritation after washing, has no stickiness on the skin after washing and has excellent hue stability in the deterioration of skin barrier function after body washing by a cleanser used during body washing.SOLUTION: There is provided a composition for improving skin barrier function after washing which comprises (A) succinoyl arginine or its salt, (B) at least one selected from polyols having 1 to 15 carbon atoms and 2 to 11 oxygen atoms, (C) at least one of a homopolymer or copolymer containing vinylpyrrolidone, dimethyldiallyl ammonium chloride, acrylic acid, methacrylic acid and an ester or amide thereof as a monomer unit as a film-forming polymer and (D) a polyphenol.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a composition for improving the skin barrier function after body washing, which is excellent in the effect of improving the skin barrier function, has low skin irritation after washing, has no stickiness on the skin after washing, and has excellent hue stability, when using a cleaning agent for body washing in the reduction of the skin barrier function after body washing.

Background Art

[0002] The skin is the largest organ covering the human body and is responsible for the skin barrier function necessary for maintaining vital activities. The skin barrier function is a function that prevents the loss of moisture in the living body to the outside world and a function that prevents the invasion of foreign substances and viruses from the outside world into the living body. When this skin barrier function deteriorates, skin irritation such as blisters and erythema is caused by the stimulation of external substances. In addition, an increase in the amount of water evaporation from the skin causes a shortage of moisture in the skin, resulting in dry skin with a rough and tight feeling, and skin problems are likely to occur. In fact, the skin of atopic dermatitis patients is chronically recognized to have a reduced skin barrier function compared to healthy people, and is characterized by dryness of the entire skin and severe itching. Although it has been reported that the application of polyphenols improves these symptoms (Non-Patent Document 1), the effect may not be sufficient in some cases. In addition, polyphenols have a defense mechanism against ultraviolet rays (Non-Patent Document 2) and an anti-inflammatory effect (Non-Patent Document 3), but the effect of improving the skin barrier function may not be sufficient in some cases. In addition, even in healthy people without skin diseases, the skin barrier function may be impaired. For example, excessive washing in daily life and the use of a body wash containing a surfactant with high detergency can be mentioned. As a result, the amount of water evaporation increases in the skin, causing a decrease in the barrier function. Conventionally, for the purpose of improving and preventing dryness caused by such a decrease in skin barrier function, a humectant has been incorporated into cosmetics. For example, Patent Document 1 discloses a skin cosmetic containing a humectant such as glycerin, polyols such as ethylene glycol, urea, hyaluronic acid, and amino acids as humectants. However, in body cleansers, the decrease in skin barrier function caused by the incorporated surfactant may not be suppressed, the effect may be temporary, and it may be insufficient to solve the above problems. Also, for example, Patent Document 2 discloses a composition containing a two-chain two-hydrophilic group-containing anionic surfactant, and it has been shown to be used as a cosmetic having a moisturizing effect. However, this may be inferior to general products in terms of the basic performance as a body cleanser, and it may also be difficult to provide a product at an economical price. Furthermore, although Patent Documents 3 to 5 also disclose effective compositions, similarly, the surfactants are special and may be inferior to general products in terms of basic performance, and it may also be difficult to provide a product at an economical price. On the other hand, as a substance for improving skin barrier function, a kind of sphingolipid obtained naturally and synthetically, such as ceramides, is well known. In Patent Document 6, a liquid crystal composition using various ceramides is disclosed. In Patent Document 7, a skin external preparation using ceramide or a ceramide-like structure is disclosed. In Patent Document 8, a skin care agent using ceramides is disclosed, showing a composition that improves skin turnover, has an effect of improving rough skin, and has excellent permeability and moisturizing properties. However, any of the ceramides used in these inventions may have low solubility in water, which may cause difficulties in preparing the composition.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Patent Document 2

[0004] [Non-Patent Document 1] Ikarashi N., et al., Acacia Polyphenol Ameliorates Atopic Dermatitis in Trimellitic Anhydride-Induced Model Mice via Changes in the Gut Microbiota, Foods., 9,773 (2020). [Non-Patent Document 2] Sharma P., et al., Tea polyphenols for the prevention of UVB-induced skin cancer, Photodermatol. Photoimmunol. Photomed., 34, 50-59 (2018). [Non-Patent Document 3] Mary Katherine Montes de Oca, Phytochemicals for the Prevention of Photocarcinogenesis, Photochem. Photobiol., 93, 956-974(2017). [Summary of the Invention] [Problems to be Solved by the Invention]

[0005] In order to solve such problems, the main object of the present invention is to provide a composition for improving the skin barrier function after body washing, which has an excellent effect of improving the skin barrier function, low skin irritation after washing, no stickiness on the skin after washing, and excellent hue stability, when using a detergent for body washing.

Means for Solving the Problems

[0006] As a result of intensive studies to solve the above problems, the present inventors have found that the above problems can be solved by a composition for improving the skin barrier function after washing, which contains an arginine derivative having a specific structure, a specific polyol, a specific film-forming polymer, and polyphenol, and thus have completed the present invention.

[0007] That is, the present invention is as follows. (1) (A) Succinoyl arginine represented by the general formula (1) or a salt thereof

Chemical formula

[0008] According to the present invention, by containing an arginine derivative having a specific structure, a specific polyol, a specific film-forming polymer, and polyphenols, in the reduction of the skin barrier function after body washing by a detergent used during body washing, it is possible to provide a skin barrier function-improving composition after washing that has an excellent effect of improving the skin barrier function, low skin irritation after washing, no stickiness of the skin after washing, and excellent hue stability. [Embodiments for Carrying Out the Invention]

[0009] Hereinafter, embodiments of the present invention will be described. The component (A) is succinoylarginine represented by the general formula (1) or a salt thereof. [Chemical Formula] (A) may be used as succinoylarginine alone or as a salt. As the salt, metal salts having potassium atoms, calcium atoms, sodium atoms, magnesium atoms, etc., alkanolamines such as monoethanolamine, diethanolamine, triethanolamine, monoisopropanolamine, diisopropanolamine, triisopropanolamine, etc. can be used. From the viewpoints of hue stability and low irritation, as the metal salt, a salt having a sodium atom and as the alkanolamine salt, a triethanolamine salt is preferable. Succinoylarginine can be obtained, for example, by reacting arginine with succinic anhydride. As commercially available products of succinoylarginine Na, Kawatect (registered trademark) SAS manufactured by Kawa Ken Fine Chemical Co., Ltd. can be mentioned.

[0010] (A) is preferably 0.1 to 2.0% by weight in the skin barrier function-improving composition after washing. If it is less than 0.1% by weight, the effect of improving the skin barrier function after washing of the present invention may not be obtained, and if it exceeds 2.0% by weight, the stickiness of the skin after washing may increase.

[0011] (B) The polyol is at least one selected from polyols having 1 to 15 carbon atoms and 2 to 11 oxygen atoms. Specifically, glycols such as glycerin, dipropylene glycol, methylene glycol, glycol, diethylene glycol, triethylene glycol, propylene glycol, tripropylene glycol, 1,3-butylene glycol, pentylene glycol, neopentyl glycol, hexylene glycol, caprylyl glycol, decylene glycol, lauryl glycol, lauryl glycol hydroxypropyl ether, etc., diols such as propanediol, 1,2-butanediol, 1,4-butanediol, 2,3-butanediol, 1,5-pentanediol, isopentyldiol, hexanediol, 1,2-hexanediol, 1,10-decanediol, ethylhexanediol, octanediol, butylethylpropanediol, methylpropanediol, etc., glycerin derivatives such as diglycerin, pentaerythritol, xylitol, fructose, sorbitol, mannitol, inositol, glucose, lactose, maltitol, sucrose, allitol, talitol, trehalose, etc. saccharides, sugar alcohols, etc. are mentioned. Preferably, glycerin and dipropylene glycol are mentioned.

[0012] (B) The content in the composition for improving skin barrier function after washing is desirably 1.0 to 10.0% by weight. If it is less than 1.0% by weight, the effect of improving the skin barrier function after washing of the present invention may decrease. Also, when blended in excess of 10.0% by weight, the stickiness of the skin after washing may increase. Component (B) may be used alone or in combination of two or more.

[0013] (C) The film-forming polymer, which is a component, is at least one of homopolymers or copolymers having vinyl pyrrolidone, dimethyldiallylammonium chloride, acrylic acid, methacrylic acid, their esters or amides as monomer units. Specifically, acrylate copolymers, polyquaternium-7, -107, (VA / butyl maleate / isobornyl acrylate) copolymer, (VP / VA) copolymer, (VP / DMAPA acrylate) copolymer, (VP / dimethylconyl acrylate / polyurethane) copolymer, (VP / dimethylconyl acrylate / polycarbamyl / polyethylene glycol) ester, (VP / DMAPA acrylate) copolymer, (VP / eicosene) copolymer, (VP / vinyl caprolactam / DMAPA acrylate) copolymer, (VP / hexadecene) copolymer, (VP / polycarbamyl polyethylene glycol) ester, (VP / polycarbamic acid polyethylene glycol) copolymer, (VP / methacrylamide / vinyl imidazole) copolymer, (VP / dimethylaminoethyl methacrylate) copolymer, (VP / dimethylaminoethyl methacrylate / polycarbamyl polyethylene glycol) ester, (acrylamide / acrylic acid) copolymer, (acrylamide / DMAPA acrylate / methoxy PEG methacrylate) copolymer, (acrylamide / ammonium acrylate) copolymer, (acrylamide / acryloyldimethyltaurine / acrylic acid) copolymer, (acrylamide propyltrimonium chloride / acrylates) copolymer, (acrylic acid / isobutyl acrylate / isobornyl acrylate) copolymer, (acrylic acid / stearyl acrylate) copolymer, (acrylic acid / acryloyldimethyltaurine) copolymer, (acrylic acid / acryloyldimethyltaurine / dimethylacrylamide) cross-polymer, (acrylic acid / diacrylic acid PEG / fibroin) copolymer, (acrylic acid / hydroxyethylacrylamide) copolymer, (acrylic acid / vinyl acetamide) copolymer, (acrylic acid / vinyl alcohol) copolymer, (acrylic acid / isobornyl methacrylate / isobutyl methacrylate) copolymer, (acrylic acid / hydrolyzed polyacrylonitrile) copolymer,(Acrylamidopropyltrimonium Chloride / Acrylamide) copolymer, (Alkyl Acrylate / HEMA) copolymer, (Alkyl Acrylate / Acrylamide) copolymer, (Alkyl Acrylate / Ethylhexyl Acrylate / HEMA / Styrene) copolymer, (Alkyl Acrylate / Stearyl Acrylate / Dimethicone Acrylate) copolymer, (Alkyl Acrylate / Diacetoneacrylamide) copolymer AMP, (Alkyl Acrylate / Methacrylic Acid) cross-polymer, (Ammonium Acrylate / Hydrolyzed Polyacrylonitrile) copolymer, (Ethylhexyl Acrylate / Methyl Methacrylate) copolymer, (Ethylhexyl Acrylate / Methoxy PEG Methacrylate / Vinyl Acetate) copolymer, (Perfluoroalkyl Ethyl Acrylate / HEMA) copolymer, (Hydroxyethyl Acrylate / Butyl Acrylate / Methoxyethyl Acrylate) copolymer, (Hydroxyethyl Acrylate / Methoxyethyl Acrylate) copolymer, (Hydroxyethyl Acrylate / Methoxyethyl Acrylate / Ethylhexyl Acrylate) copolymer, (Hydroxyethyl Acrylate / Acryloyldimethyltaurine Na) copolymer, (Butyl Acrylate / Hydroxypropyl Dimethicone Acrylate) copolymer, (Butyl Acrylate / Isopropylacrylamide / PEG Dimethacrylate) cross-polymer, (Butyl Acrylate / Glycol Dimethacrylate) cross-polymer, (Butyl Acrylate / Styrene) copolymer, (Butyl Acrylate / Ethyltrimonium Methacrylate Chloride / Styrene) copolymer, (Butyl Acrylate / Hydroxyethyl Methacrylate) copolymer, (Acrylates / t-Butylacrylamide) copolymer, (Acrylates / VA) copolymer, (Acrylates / VP) copolymer, (Acrylates / Acrylamide) copolymer, (Acrylates / Alkyl Acrylate / Alkylacrylamide) copolymer AMP, (Acrylates / Alkyl Acrylate Cross-polymer, (Acrylates / Ethylhexyl Acrylate) copolymer, (Acrylates / Ethylhexyl Acrylate / HEMA) copolymer, (Acrylates / Ethylhexyl Acrylate / Styrene) copolymer,(Acrylates / ethylhexyl acrylate / glycidyl methacrylate)crosspolymer, (acrylates / octyl acrylamide / diphenyl amodimethicone)copolymer, (acrylates / stearyl acrylate / ethylamine oxide methacrylate)copolymer, (acrylates / stearyl acrylate / dimethyl silicone methacrylate)copolymer, (acrylates / hydroxyalkyl acrylate)copolymer, (acrylates / lauryl acrylate / stearyl acrylate / ethylamine oxide methacrylate)copolymer, (acrylates / octyl acrylamide)copolymer, (acrylates / alkyl succinate / hydroxyalkyl acrylate)copolymer, (acrylates / diacetone acrylamide)copolymer, (acrylates / diacetone acrylamide)copolymer AMP, (acrylates / diacetone acrylamide)copolymer AMPD, (acrylates / PEG dimethacrylate)crosspolymer, (acrylates / dimethyl silicone)copolymer, (acrylates / vinyl neodecanoate)crosspolymer, (acrylates / methacrylamide)copolymer, (acrylates / allyl methacrylate)copolymer AMP, (acrylates / alkyl methacrylate)copolymer, (acrylates / alkyl methacrylate / methoxyethyl acrylate)crosspolymer, (acrylates / ammonium methacrylate)copolymer, (acrylates / ethylamine oxide methacrylate)copolymer, (acrylates / diethylaminoethyl methacrylate / ethylhexyl acrylate)copolymer, (acrylates / dimethylaminoethyl methacrylate)copolymer, (acrylates / stearyl methacrylate / VP)copolymer, (acrylates / stearless methacrylate)crosspolymer, (acrylates / tris(trimethylsiloxy)silylpropyl methacrylate)copolymer, (acrylates / trimethylsiloxypropyl methacrylate)crosspolymer, (acrylates / perfluorohexylethyl methacrylate)copolymer, (acrylates / propyltrimethicone methacrylate)copolymer, (acrylates / behenes methacrylate / stearless methacrylate)copolymer, (acrylates / polytrimethylsiloxy methacrylate)copolymer,(Acrylates / PEG methacrylate) copolymer, (acrylates / PEG methacrylate / perfluorooctylethyl acrylate) copolymer, (acrylates / methylstyrene / styrene) copolymer ammonium,

[0014] (Isopropylidenebisphenylbis(methacryloyloxyhydroxypropyl) / TMDI) copolymer, (eicosene / vinylpyrrolidone) copolymer, (ethylene / acrylic acid) copolymer, (ethylene / methacrylate) copolymer, (octylacrylamide / acrylates / butylaminoethyl methacrylate) copolymer, (dimethylacrylamide / acrylic acid / polystyrylethyl methacrylate) copolymer, (dimethylacrylamide / hydroxyethyl acrylate / methoxyethyl acrylate) copolymer, (dimethylacrylamide / lauryl methacrylate) copolymer, (styrene / butyl acrylate / acrylonitrile) copolymer, (styrene / acrylates) copolymer, (styrene / acrylates) / polyurethane, (styrene / acrylates / ethylhexyl acrylate / lauryl acrylate) copolymer, (styrene / acrylates / ammonium methacrylate) copolymer, (styrene / isoprene) copolymer, (styrene / vinylpyrrolidone) copolymer, (sterylester-allyl ether / acrylates) copolymer, (hydroxyethyl cellulose / phosphorylcholine glycol methacrylate) copolymer, (vinylpyrrolidone / VA) copolymer, (vinylpyrrolidone / acrylates / lauryl methacrylate) copolymer, (vinylpyrrolidone / dimethylaminoethyl methacrylate) copolymer, (propyltrimonium chloride acrylamide / dimethylacrylamide) copolymer, (polyurethane-24 / methyl methacrylate) cross-polymer, (methacrylic acid / acrylamidomethylpropanesulfonic acid) copolymer, (isobutyl methacrylate / bishydroxypropyl dimethicone acrylate) copolymer, (ethyltrimonium chloride methacrylate / hydroxyethylacrylamide) copolymer, (ethylhexyl methacrylate / methyl methacrylate / VP) copolymer, (ethylbetaine methacrylate / acrylates) copolymer, (cyclohexyl methacrylate / ethylhexyl methacrylate) copolymer, (dimethylaminoethyl methacrylate / HEMA / lauryl methacrylate) copolymer, (stearyl methacrylate / perfluorooctylethyl methacrylate) copolymer,(Behenyl Methacrylate / t-Butyl Methacrylate) Copolymer, (Behenyl Methacrylate / Perfluorooctylethyl Methacrylate) Copolymer, (Methyl Methacrylate / Acrylonitrile) Copolymer, (Methyl Methacrylate / Glycol Dimethacrylate) Cross Polymer, (Methyl Methacrylate / PEG / PPG Methacrylate) Cross Polymer, (Lauryl Methacrylate / Ethylene Glycol Dimethacrylate) Copolymer, (Lauryl Methacrylate / Glycol Dimethacrylate) Cross Polymer, (Methacryloyloxyethyl Betaine / Methacryloyloxyethyl Ammonium Chloride / Hydroxyethyl Methacrylate) Copolymer, (Methacryloyloxyethyl Betaine / Methacryloyloxyethyl Ammonium Chloride / PEG Methoxy Methacrylate) Copolymer, (Methacryloyloxyethyl Carboxy Betaine / Alkyl Methacrylate) Copolymer, (Methyl Vinyl Ether / Maleic Acid) Cross Polymer, PVP, PVP / Polycarbamyl Poly Glycol, Acrylamide Copolymer, Phenoxy PEG Acrylate, Methoxyethyl Acrylate, Lauryl Acrylate Cross Polymer, Acrylic Resin, Acrylates Cross Polymer-3, Acrylates Cross Polymer-4, Acrylates Polyacrylate Cross Polymer-9-AMP, Triacontanyl PVP, Tricontanyl PVP, Hydroxypropyl Dimethiconyl Propyl Acrylates Copolymer, Butylated PVP, Polyacrylamide, Polyacrylamide Methylpropanesulfonic Acid, Polyacrylic Acid, Ethyl Polyacrylate, Glyceryl Polyacrylate, Dimethicone PEG Polyacrylate, Dimethicone Copolyol Polyacrylate, Butyl Polyacrylate, Phosphorylcholine Glycol Polyacrylate, Methyl Polyacrylate, Polyacrylate-1, -2, -5, -6, -12, -13, -14, -15, -16, -17, -21, -22, -29, -31, -34, -36, -42, -44, -49, -51, Polyacrylate-1 Cross Polymer, Polyacrylate-2 Cross Polymer, Polyacrylate Cross Polymer-1-Na, -5, -9, Polyacrylate Cross Polymer-3, Polymethacrylamide, Polymethacrylic Acid, Ethyl Polymethacrylate, Glyceryl Polymethacrylate, Stearyl Polymethacrylic Acid, Butyl Polymethacrylate,Examples include propyl polymethacrylate, methyl polymethacrylate, methacryloylethyl betaine, methacryloyloxyethyl phosphorylcholine, polymethylsilsesquioxane / trimethylsiloxysilicic acid, PPG methacrylate, glyceryl methacrylate, tetrahydrofurfuryl methacrylate, butylcarbamoylethyl methacrylate, methyl methacrylate crosspolymer, etc. Preferably, acrylate copolymer and polyquaternium-7 are mentioned.

[0015] (C) The content in the composition for improving skin barrier function after washing should desirably be 0.05 to 1.0% by weight. If it is less than 0.05% by weight, the effect of improving the skin barrier function after washing in the present invention may decrease. Also, if it exceeds 1.0% by weight, it may accumulate on the skin surface and the stickiness of the skin after washing may increase. Component (C) may be used alone or in combination of two or more.

[0016] The polyphenol as component (D) is a plant-derived component having a plurality of phenolic hydroxy groups in the molecule. Polyphenol has the effect of improving the condition of the skin after washing and is formulated in the composition for improving skin barrier function after washing. Specific examples of polyphenol include catechins such as catechin, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, chlorogenic acid, anthocyanin, proanthocyanidin, tannin, rutin, isoflavone, ellagic acid, lignan, sesamin, curcumin, coumarin, etc. Preferably, catechin and chlorogenic acid are mentioned. Catechin is contained in components derived from tea, wine, apple, blueberry, etc. Preferably, catechin derived from tea is mentioned. Chlorogenic acid is contained in components derived from coffee, etc.

[0017] As components derived from tea containing catechins, specifically, tea leaf extract, tea pyroligneous liquor, (Aspergillus / Lactobacillus) / tea leaf fermentation extract, (Aspergillus / Lactobacillus) / tea leaf fermentation extract solution, (Aspergillus / Lactobacillus / Leuconostoc / Pediococcus / Saccharomyces / Zygosaccharomyces) / (barley seed / soybean seed / rice / wazbean seed / cowpea seed / job's tears seed / foxtail millet seed / awl millet seed / peach fruit / apple fruit / unshu mandarin fruit / mountain grape fruit / banana fruit / pear fruit / plum fruit / persimmon fruit / fig fruit / watermelon fruit / western pumpkin fruit / oyster mushroom fruit / papaya fruit / apricot fruit / japanese apricot fruit / european strawberry fruit / chestnut fruit / japanese quince fruit / jujube fruit / yuzu fruit / peach coral grosvenorii fruit / otanen carrot fruit / cabbage (leaf / stem) / perilla leaf / skunk cabbage leaf / sweet flag / japanese mugwort / yamabuki flower / sweet potato root / arrowroot tuber / carrot root / daikon radish root / duck potato rhizome / onion root / turnip root / burdock root / yam lily root / taro tuber / yam potato rhizome / kuwai tuber / licorice root / akabagin nanzo leaf / marinated kelp leaf / wakame leaf / mozuku / black walnut seed / ginkgo seed / mata tama fruit / sesame seed / yamabushitake fruiting body / maitake fruiting body / shitake fruiting body) fermentation extract, (Polygonum hydropiper / perilla / wasabi / tea / japanese quince / ginkgo / melissa / western mint / olive / marjoram / perilla / pear / sage) leaf extract, (Saccharomyces / Xylinum) / black tea culture, (Saccharomyces / Xylinum) / black tea fermentate, (Lactobacillus / Saccharomyces) / (rice bran / tea leaf extract) fermentate, (Lactobacillus / Saccharomyces / Pichia anomala) / (tea leaf extract / honey) fermentation extract solution, (Lactobacillus / Saccharomyces / Pichia anomala) / (tea leaf extract / perilla leaf extract / honey) fermentation solution, Aspergillus / (soybean / wheat germ / tea leaf / juzu dama seed / rice germ / sesame seed) fermentate, Aspergillus / tea leaf extract fermentation solution, Aspergillus / tea leaf fermentation extract, Aspergillus / tea leaf fermentation extract solution, Aspergillus / tea leaf fermentate, oolong tea extract, colloidal gold / tea leaf extract, Saccharomyces / (tea leaf / Okinawa mozuku / rice) fermentation solution, Saccharomyces / (tea leaf / jujube / carrot root) fermentation solution,Saccharomyces / chaekisu fermentation broth, chaekisu, catechin, chakals culture extract, chakals culture acclimation broth, cha flower / leaf / stem sap, cha flower extract, cha flower water, cha root extract, cha fruit extract, cha fruit oil, cha seeds, cha seed oil, cha leaves, cha leaf wax, cha leaf water, cha leaf oil, Pseudozyma epicola / (cha seed oil / glucose / soybean powder / bakuga extract / yeast extract) fermentation broth, Pseudozyma epicola / cha seed oil fermentation extract broth, hydrolyzed cha seed extract, hydrolyzed cha leaves, black tea extract, Lactobacillus / (red ginseng root / cha leaves / mugwort leaves / houttuynia cordata leaves / yuzu fruit) extract fermentation broth, Lactobacillus / (catechin / geranium robertianum / marinated kombu / equisetum arvense / resveratrol) fermentation broth, Lactobacillus / mate cha leaf fermentation broth, Lactobacillus / hydrolyzed (honey / sugarcane / (taranoki / sugina / tsukimisou / amakachazuru / english ivy / angelica keiskei / cha / cha / kumazasa / houttuynia cordata / loquat / kuko / oyster mushroom / mugwort) leaves / jujube fruit body / job's tears seeds) fermentation extract broth, green tea leaves, etc. are mentioned. Preferably, cha leaf extract, cha dry distillation liquid are mentioned.,

[0018] As components derived from sources other than tea and containing catechins, specifically, (Aspergillus / Saccharomyces) / (apple fruit / melon fruit / banana fruit / grape / sucrose) fermentation broth, (Aspergillus / Bifidobacterium / Lactobacillus / Saccharomyces / Streptococcus) / ((Akebia quinata / Uncaria tomentosa) bark / (Schisandra chinensis twig / trunk) / (garlic / onion) root / (chamomile / safflower) flower / ((Andrographis paniculata / Turnera subulata) flower / leaf / stem) / (Actinidia polygama / pineapple / apple / apricot / chili pepper / jujube / japanese apricot / loquat / grape / grapefruit / lemon / gooseberry / melon / peach / Physalis peruviana / umeboshi / plum) fruit / (Hericium caput-medusae / jujube / shiitake) fruiting body / (Aloe vera / Asparagus linearis / cabbage / oyster mushroom / loquat / persimmon / oak tree / jujube / ginkgo / bog rosemary / cucumber / parsley / peach / sesame / indocalamus) leaf / (Japanese red pine leaf / seed) / (Japanese honeysuckle leaf / stem) / onion skin / curcuma root / (burdock / carrot / canadian thistle / Ezo ume / Ulmus davidiana var. japonica / Raphanus raphanistrum subsp. maritimus / urtica dioica / giant fennel / radish / aster / trachelospermum jasminoides) root / ((giant fennel / ginger / Amadokoro) root / stem) / (Epimedium koreanum / Cuscuta japonica) seed / (Callitriche stagnalis / Taiwanese turnera) bud / stonecrop stem / mafu seaweed / kombu / mugwort / Epimedium koreanum / Cuscuta japonica / snowbell / forget-me-not / barnyard millet / japanese aucuba) extract fermentation broth,(Acetobacter / Aspergillus / Lactobacillus / Leuconostoc / Pediococcus / Saccharomyces / Zygosaccharomyces) / (Unshu mikan fruit / Malkin orange fruit / Yuzu fruit / Apple fruit / Banana fruit / Papaya fruit / Nashi fruit / Kaki fruit / Watermelon fruit / Peach fruit / Ume fruit / Fig fruit / Karin fruit / Loquat fruit / Anzu fruit / Jujube fruit / Western pumpkin fruit / Cherry fruit / Mountain grape fruit / European strawberry fruit / Peach tree peony fruit / Kuko fruit / Soybean seeds / Azuki bean seeds / Tatina tamame seeds / Rice / Barely seeds / Job's tears seeds / Inubie seeds / Awa seeds / Kibi seeds / Hongkan zow flower / Cabbage leaves / Stems / Yamagwa leaves / Egoma leaves / Satsuma potato roots / Taro tubers / Long potato rhizomes / Gingnanso / Macomb / Mozuku / Wakame / Radish roots / Kabu roots / Carrot roots / Gobo roots / Lotus rhizomes / Onion roots / Yam lily bulbs / Kanzo roots / Omodaka roots / Sesame seeds / Ginkgo seeds / Himegulmi fruit / Otaneninenjin seeds / Matatabi fruit / Yamabushitake fruiting bodies / Maitake fruiting bodies / Plum fruit / Akebi fruit / Sanzashi fruit / Sanshuyu fruit / Lychee fruit / Dokudami / Yomogi / Kumazasa leaves / Kakidooshi / Carnation flower / Suginai / Ebisugusa seeds / Western dandelion / Hikokoshi / Red flower / Oobako / Smaransassonchifolius roots / Garlic roots / Ginger rhizomes / Beet rhizomes / Polygonum odoratum rhizomes / Curcuma rhizomes / Ukogine roots / Chosen gyou seeds / Shiitake fruiting bodies / Kikurage / American grape fruit / Kikuimo tubers) fermentation extract,(Acetobacter / Aspergillus / Lactobacillus / Leuconostoc / Pediococcus / Saccharomyces / Zygosaccharomyces) / (Barley seeds / Soybean seeds / Rice / Adzuki bean seeds / Mung bean seeds / Job's tears seeds / Millet seeds / Foxtail millet seeds / Corn seeds / Kumquat fruits / American grape fruits / Apples / Mountain grape fruits / Banana fruits / Peach fruits / Persimmon fruits / Papaya fruits / Pear fruits / Watermelon fruits / Plum fruits / Fig fruits / Karin fruits / Western pumpkin fruits / European strawberries / Ningpo kumquat fruits / Yuzu fruits / Biwa fruits / Plum fruits / Jujube fruits / Castanea fruits / Kuko fruits / Mataatabi fruits / Plum fruits / Akebi fruits / Momordica grosvenori fruits / Japanese quince fruits / Sanshuyu fruits / Lychee fruits / Carthamus tinctorius roots / Sweet potato roots / Ginger tubers / Carrot roots / Onion roots / Beet roots / Taro tubers / Yam tubers / Radish roots / Kabu roots / Gobo roots / Rush rhizomes / Polymnia sonchifolia roots / Yam lily roots / Kuwae tubers / Ginger rhizomes / Garlic roots / Licorice roots / Asparagus rhizomes / Curcuma rhizomes / Ukon roots / Ukogi roots / Cabbage (leaves / stems) / Perilla leaves / Mountain mulberry leaves / Yabukanzo flowers / Houttuynia cordata / Chinese mugwort / Kumazasa leaves / Kaki dooshi / Carnation flowers / Sugina / Hikio koshi / Safflower flowers / Ooba kochi / Western dandelion / Kombu leaves / Wakame leaves / Akabagin nan sou leaves / Mozuku / Sesame seeds / Chestnut seeds / Ginkgo seeds / Ginkgo biloba seeds / Ebisugusa seeds / Grifola frondosa fruit bodies / Grifola umbellata fruit bodies / Lentinula edodes fruit bodies / Agaricus bisporus fruit bodies) fermentation extract, (Acetobacter / Bacillus / Lactobacillus / Saccharomyces) / (Rice / Barley / Soybean / Cabbage / Lettuce / Spinach / Grape / Apple / Low bush blueberry / Strawberry / European strawberry / Cranberry / Tatijakousousou / Rosemary / Chinese chives / Kumquat / Bilberry / Kanina bala / Lemongrass / Eriocephalus punctulatus / Ryokuto seeds / Adzuki bean seeds / Plum fruits / Plum fruits / Acai palm fruits) fermentation broth, (Saccharomyces / Leuconostoc) / (Apple fruits / Carrot roots / Radish roots / Cabbage leaves / Celeriac leaves / Cucumber fruits / Banana fruits / Onion roots / Gobo roots / Spinach leaves / Mandarin orange peels / Tomato fruits / Ryokuto sprouts / Japanese pumpkin fruits) extract fermentation broth,(Lactobacillus / Streptococcus thermophilus) / (Tou Mitsu / Kome Nuka / (Yuzu / Ichijiku / Kuko / Yamamomo / Plum / Rabbit Eye Blueberry / Highbush Blueberry) fruit / (Yomogi / Biwa / Lavender / Melissa / Kabu) leaf / (Melissa / Lavender / Kabu) stem / Hime Matsutake / Shiitake / Maitake / Hijiki / Makombu / Wakame) fermentation liquid, Ganoderma applanatum / Ring fermented extract, Saccharomyces / (Honey / Vinegar / Wine / Vitania somnifera root) fermentation liquid, Saccharomyces / (Melon fruit / Strawberry fruit / Grape fruit / Akebi fruit / Ring fruit / Ichijiku fruit / Banana fruit / Sucrose) fermentation liquid, Saccharomyces / (Melon fruit / Fragaria chiloensis fruit / Grape fruit / Akebi fruit / Ring fruit / Ichijiku fruit / Banana fruit / Sucrose) fermentation liquid, Saccharomyces / (Ring / Sucrose) fermentation liquid, Saccharomyces / (Ring fruit / Plum pit / Peach pit / Job's tears seed / Sucrose) fermentation liquid, Saccharomyces / (Ring fruit / Honey / Carrot root / Royal jelly / Sucrose) fermentation liquid, Saccharomyces / (Ring fruit / Melon fruit / Sucrose) fermentation liquid, Saccharomyces / (Ring fruit / Hydrolyzed conchiolin protein / Sucrose) fermentation liquid, Saccharomyces / Ring fruit fermentation liquid, Safflower oil fatty acid epigallocatechin, Schizosaccharomyces / ((Tomato / Cucumber / Pineapple / Lemon / Ring / Pumpkin / Papaya / Watermelon / Melon / Plum / Peach / Ichijiku / Akebi / Karin / Strawberry / Grape / Actinidia deliciosa / Ume / Biwa / Smomo / Tougan) fruit / (Daikon / Cabbage / Carrot / Kidachi aloë / Kumazasa / Oyster / Perilla) leaf / (Daikon / Carrot / Potato / Satsuma potato / Taro / Hasu / Gobo / Yam potato / Ginger) root / (Soybean / Azuki / Job's tears / Awa / Kibi) seed / Tsukubuki stem / Suginai / Celery / Honeybee / Kome / Shiitake fruiting body / Wakame) fermentation liquid, Highbush Blueberry fruit extract, Highbush Blueberry seeds, Highbush Blueberry seed oil, Pantoea vagans / (Ring juice / Ume fruit) fermented extract, Grape wine, Ring extract, Ring callus extract, Ring tannin, Ring fruit, Ring fruit extract, Ring fruit water, Ring fruit cultured cell extract, Ring fruit juice, Ring peel, Ring peel extract,Apple pericarp wax, apple flower extract, apple flower water, apple stem extract, apple root extract, apple seed extract, apple seed oil, apple carpel, apple water, apple fiber, apple oil, lobe bush blueberry fruit, lobe bush blueberry fruit extract, lobe bush blueberry fruit juice, lobe bush blueberry seeds, lobe bush blueberry leaf extract, wine, wine extract, lactic acid bacteria / (orange peel / carrot root / (apple / cucumber / lemon) fruit) extract fermentation broth, lactic acid bacteria / apple juice fermentation broth, lactic acid bacteria / wine extract fermentation broth, epigallocatechin gallate, epigallocatechin gallate glucoside, etc. are mentioned.

[0019] As components derived from coffee containing chlorogenic acid, specifically, coffee seed extract, Aspergillus / (Arabica coffee tree seeds / rice) fermentation broth, Arabica coffee tree fruit extract, Arabica coffee tree seeds, Arabica coffee tree seed oil, Arabica coffee tree leaf / seed extract, Arabica coffee tree leaf cell extract, coffee extract, coffee tree extract, Robusta coffee tree seeds, Robusta coffee tree seed extract, etc. are mentioned. Preferably, coffee seed extract is mentioned.

[0020] As components containing polyphenols other than catechin and chlorogenic acid, specifically, (Aspergillus / Lactobacillus / Saccharomyces) / (soybean / Plantago asiatica / radish / broccoli / cauliflower / rice / barley / soybean sprout / Aster scaber / black sesame / sage / Polygonatum odoratum / Aster ageratoides var. turczaninowii / Polygonum aviculare / alfalfa / Coltsfoot) germinated fermentation broth extract, (Cryptococcus / Phyllobacterium) / grape extract fermented residue, (Kluveromyces / Lactobacillus / Leuconostoc) / soybean fermentation broth, (Clostridium akagii / butyric acid bacteria / Bacillus) / (honey / goji berry / soybean / ginger root / jujube fruit) fermented extract solution, (Bacillus / Monascus) / (Japanese holly leaf / soybean) fermentation broth, (Bacillus / Monascus) / (Japanese butterbur flower / leaf / soybean) fermentation broth, (Bacillus / Monascus) / (Japanese angelica root / soybean) fermentation broth, (Bacillus / Monascus) / (Arctium lappa root / soybean) fermentation broth, (Bacillus / Monascus) / (krill / soybean) fermentation broth, (Bacillus / Monascus) / (black sesame seed / soybean) fermentation broth, (Bacillus / Monascus) / (pomegranate fruit / soybean) fermentation broth, (Bacillus / Monascus) / (jujube fruit / soybean) fermentation broth, (Bacillus / Monascus) / (pistachio fruit / soybean) fermentation broth, (Bacillus / Monascus) / (Japanese quince flower / soybean) fermentation broth, (Bacillus / Monascus) / (grape bud / rice bran) fermentation broth, (Bacillus / Monascus) / (Cornus officinalis fruit / soybean) fermentation broth, (Bacillus / Monascus) / (Prunus salicina Lindl. fruit / soybean) fermentation broth, (Bacillus / Monascus) / (Lythrum salicaria seed / soybean) fermentation broth, (Bacillus / Lactobacillus / Monascus) / (rice bran extract / soybean extract) fermentation broth, (Acacia concinna / jojoba wax / sunflower seed wax) polyglyceryl-3 esters, (lime fruit / lemon fruit) water, Pinus densiflora Sieb. & Zucc. leaf oil, Acacia concinna fruit, Acacia concinna fruit extract, Acacia senegal extract, Acacia senegal gum extract, Acacia senegal flower / stem extract, Acacia seyal gum, Acacia seyal gum extract, Acacia decurrens extract, Acacia decurrens flower extract, Acacia victoriae fruit extract, Acacia victoriae seed extract, Acacia victoriae seed oil, Pinus densiflora Sieb. & Zucc. extract, Pinus densiflora Sieb. & Zucc. root extract, Pinus densiflora Sieb. & Zucc. branch / leaf extract,Japanese red pine bark extract, Japanese red pine leaves, Japanese red pine leaf extract, Acidophilus / grape ferment, Ascorbic acid (orange / lemon / lime) polypeptide, Aspergillus / (glucose / soybean / starch) fermentation broth, Aspergillus / (walnut seed / peach seed / apricot seed / plum seed) fermentation broth, Aspergillus / buckwheat fermentation extract, Aspergillus / soybean sprout fermentation extract, Aspergillus / soybean sprout fermentation broth, Aspergillus / soybean sprout ferment, Aspergillus / soybean seed extract fermentation broth, Aspergillus / mandarin orange peel fermentation broth, Aspergillus / defatted soybean seed fermentation extract, Aspergillus / defatted soybean seed fermentation broth, American grape fruit extract, American grape fruit water, Aleppo pine branch / leaf oil, Anthocyanin, Italian black pine seed oil, Strawberry cotyledon extract, Strawberry tree fruit extract, Strawberry tree leaf extract, Strawberry fruit, Strawberry fruit extract, Strawberry fruit water, Strawberry fruit juice, Strawberry flower extract, Strawberry seed extract, Strawberry seed oil, Strawberry leaf extract, Japanese apricot fruit extract, Japanese apricot fruit water, Japanese apricot peel extract, Japanese apricot peel water, Japanese apricot peel oil, Turmeric, Turmeric extract, Turmeric callus conditioning culture solution, Turmeric callus lysate, Turmeric Penicillium ferment, Turmeric root, Turmeric root extract, Turmeric rhizome extract, Turmeric rhizome oil, Turmeric root water, Turmeric root oil, Turmeric leaf, Turmeric leaf extract, Unshu mikan fruit, Unshu mikan fruit extract, Unshu mikan fruit water, Unshu mikan fruit oil, Unshu mikan fruit juice, Unshu mikan fruit juice fermentation broth, Unshu mikan peel, Unshu mikan peel extract, Unshu mikan peel oil, Unshu mikan flower extract, Unshu mikan flower water, Ezo snake strawberry juice, Ezo snake strawberry fruit, Ezo snake strawberry fruit extract, Ezo snake strawberry fruit water, Ezo snake strawberry seed, Ezo snake strawberry seed oil, Ellagic acid, Erotylomyces / soybean fermentation broth, Endomyces / strawberry juice fermentation broth, Oshima black pine sprout / leaf extract, Oshima cherry flower extract, Oshima cherry leaf extract, Oshima cherry leaf water, Oshima benimikan extract, Oshima benimikan peel extract, Oshima benimikan peel oil, Oshima mountain cherry fruit extract, Wild strawberry fruit extract, Wild strawberry root extract, Nashi pear fruit water, Orange, Orange extract, Orange callus culture extract, Orange flower extract, Orange flower water,Orange raffia oil, orange fruit, orange fruit extract, orange fruit water, orange juice, orange peel, orange peel extract, orange peel wax, orange peel oil, orange flower extract, orange flower wax, orange flower water, orange flower oil, orange seed extract, orange seed oil, orange fiber, orange oil, orange leaf extract, cocoa extract, cocoa carob, cocoa fruit, cocoa fruit extract, cocoa shell, cocoa butter, cocoa seeds, cocoa seed extract, cocoa seed shell extract, cocoa seed water, cocoa leaf cell extract, kaki extract, kaki tannin, kaki fruit, kaki fruit extract, kaki peel extract, kaki leaf, kaki leaf extract, kabosu juice, kabosu peel water, kabosu peel oil, larch resin, larch wood extract, strawberry extract, strawberry fruit extract, strawberry juice, kiwamatsutake mushroom seed oil, kumquat fruit extract, kudzu flower / leaf / stem extract, kudzu root, kudzu root extract, kudzu root nodule extract, kudzu leaf / stem extract, coumarin, curcumin, grapefruit extract, grapefruit juice, grapefruit fruit extract, grapefruit fruit water, grapefruit juice, grapefruit peel, grapefruit peel extract, grapefruit peel water, grapefruit peel oil, grapefruit seed extract, grapefruit seed oil, grapefruit leaf extract, chromic strawberry fruit extract, chromic strawberry juice, cinnamon extract, cinnamon oil, peach fruit extract, peach juice, peach seed oil, peach leaf extract, peach leaf protoplast, goshio strawberry fruit extract,

[0021] Sesame seeds, sesame seed extract, sesame seed fat, sesame seed oil, germinated sesame seed extract, sesame oil, unsaponifiable matter of sesame oil, fermented product of rice bran - soybean peptide, cherry leaf extract, Saccharomyces / (clove flower / lavender flower / anise fruit / cabbage fruit / coriander fruit / Chinese bellflower fruit / cowslip fruit / caraway fruit / parsley fruit / lemongrass leaf / cowslip leaf / ginkgo leaf / perilla leaf / sage leaf / Chinese artichoke leaf / ginger root / cowslip root / Ceylon cinnamon stem / Chinese artichoke stem / honey) fermented extract, Saccharomyces / (spiderwort root / phanerophlebia japonica bark / button root / peach pit) fermented extract liquid, Saccharomyces / (grape fruit / yuzu fruit) fermented liquid, Saccharomyces / cherry fruit fermented extract, Saccharomyces / japanese apricot bark extract fermented liquid, Saccharomyces / soybean protein fermented product, Saccharomyces / strawberry fruit fermented liquid, Saccharomyces / grape fruit / seed / stalk fermented extract, Saccharomyces / grape pomace fermented liquid, Saccharomyces / grape fermented extract, Saccharomyces / yuzu peel fermented liquid, Japanese flowering cherry, Japanese flowering cherry extract, citrus kishu fruit water, Japanese mountain cherry fruit extract, Japanese mountain cherry fruit wax, sweet acacia extract, sweet acacia flower extract, sweet acacia flower wax, sweet acacia flower oil, sweet orange fruit extract, sweet orange fruit water, sweet orange peel extract, sweet orange oil, sudachi fruit extract, sudachi fruit juice, sudachi peel extract, sudachi peel oil, prickly - leaved cherry fruit extract, prickly - leaved cherry flower extract, prickly - leaved cherry wood extract, dwarf cherry extract, dwarf cherry fruit extract, dwarf cherry fruit water, dwarf cherry fruit juice, dwarf cherry flower extract, dwarf cherry bud extract, dwarf cherry shell, dwarf cherry seed oil, dwarf cherry leaf cell extract, peach fruit extract, peach fruit juice, European cherry fruit, European cherry fruit extract, European cherry flower extract, European cherry seed extract, European cherry seed oil, European cherry wood extract, European wild strawberry fruit extract, European wild strawberry fruit juice, European wild strawberry leaf extract, Ceylon cinnamon bark, Ceylon cinnamon bark extract, Ceylon cinnamon bark oil, Ceylon cinnamon leaf oil, buckwheat stem extract, buckwheat seed extract, buckwheat flour, buckwheat leaf extractSomei Yoshino flower / twig water, Somei Yoshino flower extract, Somei Yoshino branch / leaf extract, Somei Yoshino bark extract, Somei Yoshino leaf extract, Somei Yoshino leaf water, soybean isoflavone, soybean extract, soybean callus culture, soybean sprout extract, soybean root nodule extract, soybean lipid, soybean seed, soybean seed extract, soybean seed coat extract, soybean fiber, soybean placenta extract, soybean meal, soybean fermentation extract, soybean powder, hydrolyzate of soybean powder, soybean oil, soybean oil cake extract, unsaponifiable matter of soybean oil, Taiwan banana fruit water, Tacuma datchi pericarp water, onion outer skin, onion root extract, Tamara nikkei leaf oil, tannic acid, Chishima strawberry callus extract, Chishima strawberry fruit extract, vine peach fruit extract, vine peach seed extract, vine peach seed oil, Tokin can fruit extract, Tokin can fruit juice, Tokkuri strawberry fruit extract, Tokkuri strawberry root extract, troxerutin, eggplant fruit, eggplant fruit extract, eggplant root extract, nattou gum, natsumikan fruit water, natsumikan fruit oil, natsumikan pericarp extract, natsumikan pericarp water, natsumikan pericarp oil, natsumikan flower water, natsumikan flower oil, parsley extract, parsley seed oil, parsley leaf, parsley leaf extract, parsley leaf oil, Bacillus / (Japanese red pine leaf / Koyama pine leaf / black pine leaf / soybean) fermentation broth, Bacillus / (Aphanizomenon flos-aquae / soybean) fermentation broth, Bacillus / (Amagasatake / soybean) fermentation broth, Bacillus / (apricot seed / thin carrot extract / azuki bean seed / soybean seed / wheat bran / onamo-mi fruit extract) fermentation extract, Bacillus / (fig fruit / soybean) fermentation broth, Bacillus / (turmeric root / soybean) fermentation broth, Bacillus / (Okinawa mozuku / soybean) fermentation broth, Bacillus / (oyster leaf / soybean) fermentation extract broth, Bacillus / (clover flower / soybean) fermentation broth, Bacillus / (kouou sou flower / soybean) fermentation broth, Bacillus / (rice bran extract / soybean extract) fermentation broth, Bacillus / (soybean / folic acid) fermentation extract, Bacillus / (camellia seed / soybean) fermentation extract, Bacillus / (job's tears seed / soybean) fermentation broth, Bacillus / (rose flower / soybean) fermentation broth, Bacillus / (murasaki root / soybean) fermentation broth, Bacillus / (Larrea mexicana / soybean) fermentation broth, Bacillus / (lycium fruit / soybean) fermentation broth, Bacillus / (rosemary leaf / soybean) fermentation extract broth, Bacillus / (royal jelly / soybean) fermentation broth extract,Bacillus / Unshu Mikan pericarp extract fermentation broth, Bacillus / Soybean fermentation extract, Hassaku / Natsumikan fruit, Hassaku / Natsumikan fruit juice, Hassaku / Natsumikan pericarp, Hassaku fruit extract,

[0022] Banana fruit, banana fruit extract, banana juice, banana pulp extract, banana peel extract, banana flower extract, banana flower water, banana water, banana leaf extract, Hamabe grape fruit extract, bioflavonoid, bitter orange fruit extract, bitter orange peel, bitter orange peel extract, bitter orange peel oil, bitter orange flower extract, bitter orange flower water, bitter orange flower oil, bitter orange oil, bitter orange leaf / twig oil, bitter orange leaf / twig extract, bifidobacterium / soybean extract fermentate, Japanese apricot flower / leaf / stem extract, Fukuremikan peel extract, mimosa acacia flower wax, Pseudozyma epicola / (soybean powder / Argania spinosa kernel oil) fermentation broth, Pseudozyma epicola / (soybean powder / olive fruit oil) fermentation broth, grape extract, grape callus culture extract, grapevine extract, grapevine sap, grape juice extract, grape fruit, grape fruit extract, grape fruit cell extract, grape fruit water, grape fruit growth point cell culture, grape juice, grape juice fermented residue oil, grape peel extract, grape flower extract, grape flower cell extract, grape bud extract, grape root extract, grape seeds, grape seed / skin / stem extract, grape seed extract, grape seed oil, grape sap, grape water, grape skin, grape leaf / seed / skin extract, grape leaf extract, grape leaf water, grape leaf oil, loquat leaf extract, hesperidin, Aspergillus benzoase / (Japanese butterbur leaf / soybean) fermentation broth, Aspergillus benzoase / (turmeric root / barley bran) fermentation extract broth, Aspergillus benzoase / (turmeric root / barley bran) fermentate, Aspergillus benzoase / (lettuce root / soybean) fermentation broth, Aspergillus benzoase / turmeric fermentate extract, Holomui strawberry fruit extract, Holomui strawberry juice, Holomui strawberry seed extract, Holomui strawberry seed oil, Maclura cochinchinensis leaf prenylflavonoid, maseline, Marukin can fruit extract, mandarin orange, mandarin orange fruit, mandarin orange fruit extract, mandarin orange fruit water, mandarin orange juice, mandarin orange peel, mandarin orange peel extract, mandarin orange peel oil, mandarin orange water, mandarin orange oil, mandarin orange leaf oil, mimosa acacia seed extract, peach gum, peach callus culture extract, peach fruit extract, peach fruit water, peach juice, peach flower, peach flower extract, peach bud extract, peach pit, peach pit oil, peach seed extract, peach leaf extractPrunus jamasakura flower extract, Prunus jamasakura branch / leaf extract, Prunus jamasakura bark extract, Prunus jamasakura placenta culture extract, Vitis thomsonii callus cell acclimation culture solution, Vitis thomsonii fruit extract, Vitis thomsonii sap, Chaenomeles japonica fruit extract, Chaenomeles japonica bark, Chaenomeles japonica bark extract, Citrus junos extract, Citrus junos fruit, Citrus junos fruit extract, Citrus junos fruit water, Citrus junos fruit oil, Citrus junos fruit juice, Citrus junos pericarp, Citrus junos pericarp extract, Citrus junos pericarp water, Citrus junos pericarp oil, Citrus junos flower oil, Citrus junos seed extract, Citrus junos seed oil, Fragaria × ananassa fruit, Fragaria × ananassa fruit water, Fragaria × ananassa seeds, Fragaria × ananassa seed extract, Fragaria × ananassa seed oil, Fragaria × ananassa leaves, Fragaria × ananassa leaf extract, Fragaria × ananassa leaf wax, Fragaria × ananassa leaf cell culture, Citrus aurantiifolia fruit, Citrus aurantiifolia fruit extract, Citrus aurantiifolia fruit water, Citrus aurantiifolia fruit juice, Citrus aurantiifolia pericarp, Citrus aurantiifolia pericarp extract, Citrus aurantiifolia pericarp oil, Citrus aurantiifolia flower extract, Citrus aurantiifolia seed oil, Citrus aurantiifolia oil, Aspergillus oryzae / soybean protein ferment, Rhizopus / soybean fermentation extract solution, rutin, Leuconostoc / grape juice fermentation broth, Citrus limon extract, hydrolyzed Vitis vinifera pericarp extract, hydrolyzed Fragaria nipponica fruit, hydrolyzed Citrus sinensis fruit extract, hydrolyzed Citrus reticulata blanco pericarp extract, hydrolyzed Eriobotrya japonica fruit, hydrolyzed Glycine max seeds, hydrolyzed Glycine max seed extract, hydrolyzed Glycine max extract, hydrolyzed Glycine max protein, hydrolyzed Glycine max fiber, hydrolyzed Vitis vinifera fruit, hydrolyzed Vitis vinifera skin, hydrolyzed proanthocyanidins, Glycyrrhiza flavonoids, hydrogenated soybean oil, hydrogenated Vitis vinifera seed oil, Bifidobacterium bifidum fermentation broth, soybean isoflavones, Lactococcus lactis / grape juice fermentation broth, Lactobacillus plantarum / (Prunus mume flower extract / Glycyrrhiza glabra root extract / Polygonum cuspidatum root extract / Pueraria lobata root extract / Dioscorea opposita fruit extract / Angelica gigas root extract / Olive flower extract) fermentation broth, Lactobacillus plantarum / (Coix lacryma-jobi seeds / Nymphaea tetragona seeds / Capsicum annuum seeds / Glycine max seeds / germinated Oryza sativa) extract fermentation broth, Lactobacillus plantarum / (milk solids / soybean oil) ferment, Lactobacillus plantarum / Theobroma cacao fruit fermentation broth, Lactobacillus plantarum / Glycine max extract fermentation broth, Lactobacillus plantarum / Glycine max seed fermentation extract solution, Lactobacillus plantarum / Glycine max fermentation extract, Lactobacillus plantarum / grape juice fermentation broth, Lactobacillus plantarum / germinated Glycine max fermentation broth, etc.

[0023] The content in the composition for improving skin barrier function after washing of component (D) is desirably 0.0001 to 0.1% by weight. If it is less than 0.0001% by weight, the effect of improving skin barrier function after washing of the present invention may decrease. Further, when it is blended in an amount exceeding 0.1% by weight, it may be colored over time at high temperatures. Component (D) may be used alone or in combination of two or more.

[0024] The composition for improving skin barrier after washing consists of the above components (A) to (D). By adding the composition for improving skin barrier after washing to a generally used body wash, the effect of the present invention is manifested. The addition amount of the composition for improving skin barrier function after washing to the body wash can be adjusted as appropriate.

[0025] Although not particularly limited, examples of components used in body cleansers include anionic surfactants such as higher fatty acid salts such as potassium laurate, potassium myristate, and potassium palmitate; polyoxyethylene alkyl ether sulfates such as sodium lauryl sulfate; alkyl sulfates; α-olefin sulfonates; N-acylmethyl taurates; alkyl sulfosuccinates; polyoxyethylene alkyl sulfosuccinates; alkyl sulfonates; internal olefin sulfonates; N-acyl taurates; acyl isethionates; α-sulfo fatty acid methyl ester salts; acylmethylalanine salts (commercially available products include Alanon (registered trademark) ALE, ACE, ALTA, AME manufactured by Kawaken Fine Chemicals Co., Ltd.); acyl sarcosinates (Soipon (registered trademark) SLP, SLE, SCE, SLTA, M-30 manufactured by Kawaken Fine Chemicals Co., Ltd.); acyl silk amino acid salts (Kawasilk (registered trademark) S manufactured by Kawaken Fine Chemicals Co., Ltd.); N-acyl glutamates; N-acyl aspartates; N-acyl glycines; N-methyl-N-acyl taurates; N-acyl-N-hydroxyethyl-β-alanine salts; poly(1 to 10)oxyethylene lauryl ether acetates; poly(1 to 10)oxyethylene coconut oil alkyl ether acetates; poly(1 to 10)oxyethylene tridecyl ether acetates; poly(1 to 10)oxyethylene lauroyl ethanolamide ether acetates; poly(1 to 10)oxyethylene coconut oil fatty acid ethanolamide ether acetates; poly(1 to 10)N-methyl-lauroyl ethanolamide ether acetates; poly(1 to 10)N-ethyl-lauroyl ethanolamide ether acetates; poly(1 to 10)oxyethylene N-methyl-coconut oil fatty acid ethanolamide ether acetates; poly(1 to 10)oxyethylene N-ethyl-coconut oil fatty acid ethanolamide ether acetates, etc.

[0026] Although not particularly limited, as components used in body cleansers, nonionic surfactants include cocamidomethyl MEA, PPG-2 cocamide (as an available commercial product, Amizet (registered trademark) 1PC manufactured by Kawaken Fine Chemicals Co., Ltd.), cocamide MEA (as an available commercial product, Amizole (registered trademark) CME manufactured by Kawaken Fine Chemicals Co., Ltd.), cocamide DEA (Amizole CDE-G manufactured by Kawaken Fine Chemicals Co., Ltd.), palm kernel oil fatty acid amide DEA (Amizole KD-1 manufactured by Kawaken Fine Chemicals Co., Ltd.), lauramide DEA (Amizole LDE-G manufactured by Kawaken Fine Chemicals Co., Ltd.), (lauramide / myristamide) DEA (Amizole LMDE-Y manufactured by Kawaken Fine Chemicals Co., Ltd.), lauramide MIPA (Amizole PLME-A manufactured by Kawaken Fine Chemicals Co., Ltd.), PEG-3 lauramide (Amizet 2L-Y manufactured by Kawaken Fine Chemicals Co., Ltd.), (lauryl / myristyl) glycol hydroxypropyl ether (Biscosafe (registered trademark) LMPE manufactured by Kawaken Fine Chemicals Co., Ltd.), 2-ethylhexyl glyceryl ether, glyceryl 2-ethylhexanoate, glyceryl (behenic acid / eicosanedioic acid), polyglyceryl (behenic acid / eicosanedioic acid), alkyl glyceryl ether, alkyl glucoside, alkyl saccharide, ethylene oxide derivative of alkylphenol formalin condensate, alkyl polyglucoside, alkylene glycol fatty acid esters, polyoxyethylene glyceryl isostearate, isodecyl glyceryl ether, polyethylene glycol ether of diester or triester of oleic acid and methyl glucose, glycerin alkyl ether, glycerin fatty acid ester, PEG-120 methyl glucose dioleate, ethylene glycol distearate, polyethylene glycol dipolyhydroxystearate, sucrose fatty acid esters, sesquioleic acid sorbitan, cetearyl-60 myristyl glycol, sorbitan monostearate, sorbitan fatty acid esters, sorbit fatty acid ester, polyoxyethylene sorbitol tetraisostearate, tetraglycerin monolauryl ether, tetraalkylene oxide ethylene diamine condensate, tri(caprylic / capric acid) glyceryl, Pluronic (registered trademark) type, propylene glycol fatty acid ester,Pentaerythritol fatty acid ester, polyethylene glycol monooleate, polyethylene glycol type nonionic surfactant, polyethylene glycol fatty acid ester, polyoxyalkylene-alkyl copolymerized organopolysiloxane, polyoxyalkylene alkyl ethers, polyoxyalkylene alkyl phenyl ethers, polyoxyalkylene alkenyl ethers, polyoxyalkylene ethers, polyoxyalkylene esters, polyoxyalkylene glycol, polyoxyalkylene glycol fatty acid ester, polyoxyalkylene glycerin fatty acid ester, polyoxyalkylene dimethyl dimer diol ether, polyoxyalkylene sorbitan fatty acid ester, polyoxyalkylene sorbit fatty acid ester, polyoxyalkylene castor oil derivative, polyoxyalkylene hydrogenated castor oil derivative, polyoxyalkylene fatty acid amide, polyoxyalkylene fatty acid ester, polyoxyalkylene modified organopolysiloxane, polyoxyethylene-POP alkyl ethers, polyoxyethylene alkylamine, polyoxyethylene alkyl allyl ether, polyoxyethylene alkyl ethers, polyoxyethylene alkyl thioether, polyoxyethylene alkyl phenyl ethers, polyoxyethylene isostearyl ether, polyoxyethylene-octyldodecyl ether, polyoxyethylene glyceryl cocoate, polyoxyethylene-glycerin monoisostearate, polyoxyethylene glycerin fatty acid esters, polyoxyethylene cholestanol ether, polyoxyethylene cholesteryl ether, polyoxyethylene stanol ether, polyoxyethylene stearyl ether, polyoxyethylene sterol ether, polyoxyethylene cetostearyl hydroxymyristylene ether, polyoxyethylene sorbitan monofatty acid esters such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene-sorbit monolaurate, polyoxyethylene sorbit fatty acid esters, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene nonyl phenyl ether, polyoxyethylene castor oil, polyoxyethylene phytostanol ether,Polyoxyethylene phytosteryl ether, polyoxyethylene phytosterol ether, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene polyoxypropylene butyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene polyoxypropylene glycols, polyoxyethylene polyoxypropylene glyceryl ethers, polyoxyethylene methyl glucoside, polyoxyethylene coconut oil fatty acid PEG-glyceryl, polyoxyethylene lauryl ether, polyoxyethylene lanolin alcohol, polyoxyethylene lanolin derivatives, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil fatty acid ester, polyoxyethylene hydrogenated castor oil derivatives, polyoxyethylene fatty acid ester, polyoxyethylene fatty acid diester, polyoxysorbitol fatty acid ester, polyoxybutylene·polyoxyethylene·polyoxypropylene glyceryl ether, polyoxypropylene alkyl ether, polyoxypropylene diglyceryl ethers, polyoxypropylene monooctyl ether, polyglyceryl ether, polyglyceryl monoalkyl ether, polyglycerin alkyl ether, polyglycerin laurate, polyglycerin fatty acid ester, polysorbate, polypropylene glycol caprylyl ether, monoalkyl glyceryl ether, monoalkenyl glyceryl ether, ethylene glycol monooleate, monoglyceride derivatives, monoglycerin alkyl ether, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monolaurate, PEG-4 laurate, diethylene glycol laurate, propylene glycol laurate, hydrogenated castor oil derivatives, higher fatty acid sucrose ester, fatty acid oxybutylene, fatty acid glycol ester, fatty acid glycerin ester, fatty acid dioxybutylene, block polymers containing aliphatic alkyl groups, polyhydric alcohol type nonionic surfactants, polyhydric alcohol fatty acid esters, sugar alcohol fatty acid esters, sugar ether systems, sugar ester systems, etc. can be mentioned.,

[0027] Although not particularly limited, examples of components used in body cleansers include amphoteric surfactants such as amide propyl betaine type, sulfobetaine type, imidazoline type, alkyl betaine type, and amine oxide type. Specific examples of amide propyl betaine type amphoteric surfactants include cocamidopropyl betaine (as an available commercial product, Softazoline (registered trademark) CPB manufactured by Kawaken Fine Chemicals Co., Ltd.), (capryl / capramid) propyl betaine, isostearamidopropyl betaine, undecylenamidopropyl betaine, oliveamidopropyl betaine, oleamidopropyl betaine, shea butter amidopropyl betaine, soyamidopropyl betaine, palm kernel fatty acid amidopropyl betaine (as an available commercial product, Softazoline PKPB manufactured by Kawaken Fine Chemicals Co., Ltd.), babassuamidopropyl betaine, myristamidopropyl betaine, meadowfoamamidopropyl betaine, lauramidopropyl betaine (as an available commercial product, Softazoline LPB manufactured by Kawaken Fine Chemicals Co., Ltd.), ricinoleic acid amidopropyl betaine, milk fat fatty acid amidopropyl betaine, horse oil fatty acid amidopropyl betaine, and the like. Specific examples of sulfobetaine type amphoteric surfactants include lauryl hydroxysulfobetaine (lauryl hydroxysultaine), lauramidopropyl hydroxysultaine (as an available commercial product, Softazoline LSB manufactured by Kawaken Fine Chemicals Co., Ltd.), cocamidopropyl hydroxysultaine, erucamidopropyl hydroxysultaine, methoxycinnamidopropyl hydroxysultaine, and the like.As imidazoline-type amphoteric surfactants, specifically, Na cocoamphoacetate (as commercially available products, Softazoline CH and CL manufactured by Kawaken Fine Chemicals Co., Ltd.), Na arganamphoacetate, Na isostearamphoacetate, Na olive amphoacetate, Na cocoa butter amphoacetate, Na caproamphoacetate, Na sesame amphoacetate, Na rice bran amphoacetate, Na shea butter amphoacetate, Na sweet almond amphoacetate, Na palm amphoacetate, Na babassu amphoacetate, Na peanut amphoacetate, Na sunflower seed amphoacetate, Na grape seed amphoacetate, Na mango amphoacetate, Na cottonseed amphoacetate, Na lauroamphoacetate (as commercially available products, Softazoline LHL manufactured by Kawaken Fine Chemicals Co., Ltd.), 2Na cocoamphodiacetate, 2Na soybean oil fatty acid amphodiacetate, 2Na lauroamphodiacetate, Na cocoamphopropionate (as commercially available products, Softazoline NS, SF, and SFD manufactured by Kawaken Fine Chemicals Co., Ltd.), 2Na cocoamphodipropionate, etc. can be mentioned. As alkyl betaine-type amphoteric surfactants, specifically, hydroxyalkyl (C12-14) hydroxyethyl sarcosine (as commercially available products, Softazoline LMEB manufactured by Kawaken Fine Chemicals Co., Ltd.), lauryl betaine, cocobetaine, etc. can be mentioned. As amine oxide-type amphoteric surfactants, specifically, lauramidopropylamine oxide (as commercially available products, Softazoline LAO-C manufactured by Kawaken Fine Chemicals Co., Ltd.), cocamidopropylamine oxide, wheat germ oil fatty acid amidopropylamine oxide, soyamidopropylamine oxide, myristamidopropylamine oxide, milk fat fatty acid amidopropylamine oxide, oleamine oxide, cocoamine oxide, dihydroxyethylcocoamine oxide, dihydroxyethyllauramine oxide, stearamine oxide, decylamine oxide, decyltetradecylamine oxide, behenamine oxide, myristamine oxide, lauramine oxide, etc. can be mentioned.

[0028] As other components, for example, (aminoethylaminopropylmethylcon / dimethylcon) copolymer, (divinyldimethylcon / dimethylcon) copolymer, (dimethylcon / vinyldimethylcon) cross-polymer, (meth)acrylic silicone-based graft copolymer, (meth)acrylic-modified silicone, 1,1,1-triphenyl-3,3-dialkyl-3-alkenyldisiloxane, EO-modified silicone, PEG / PPG-dimethylcon, PEG-dimethylcon, acrylic silicones, amidoalkyl-modified polysiloxane, silicone having an aminoalkyl side chain, aminoethylaminopropylmethylsiloxane, aminoglycol-modified polysiloxane, aminophenyl-modified polysiloxane, aminopropyldimethylcon, aminopropyltrialkoxysilane, aminoethylaminopropylmethylcon / dimethylcon copolymer, aminopropylmethylsiloxane / dimethylsiloxane copolymer, aminopolyether-modified silicone, amino-modified silicone, amino-modified silicone / polyether block copolymer, amodimethicone, alkyl-modified silicone, alcohol-modified silicone, alkoxy-modified silicone, epoxy-modified silicone, epoxyaminosilane copolymer, polysiloxane having an oxiranyl group or an oxetanyl group, carbinol-modified polysiloxane, carboxy-modified silicone, glyceryl-modified silicone, diphenylpolysiloxane, dimethiconol, dimethylcon, dimethylcon copolyol, dimethylcon copolymer, dimethylsiloxane / methyl(polyoxyethylene)siloxane copolymer, dimethylsiloxane copolymer, silanol group-terminated dimethylpolysiloxane, silicone elastomer, silicone quaternium-16 / glycidoxydimethylcon cross-polymer, silicone graft polymer, silicone phosphate triester, silicone wax, decyltrisiloxanecarboxylic acid, trimethylsilylamodimethicone, trimethylsilyl group-terminated dimethylpolysiloxane, trimethylsiloxysilicic acid, pantenyl succinic acid silicone quaternium-2, bis(alkoxy)PG amodimethicone, bis(PEG / PPG) dimethylcon, bis(cetearyl) amodimethicone, phenyltrimethicone, fluorine-modified silicone, fluoroalkyl group-containing organopolysiloxane, betaine-modified silicone,Polyamino-modified silicone, polyether-alkyl co-modified polysiloxane, polyether-modified silicone, polyoxyalkylene-alkyl co-modified silicone, polyoxyalkylene-modified silicone, silicone having a polyoxyalkylene side chain, aminopolyether-modified silicone containing a polyoxyalkylene structure, polyoxyethylene / polyoxypropylene copolymer-modified polysiloxane, polyglycidol-modified silicone, polyglycerin-alkyl co-modified polysiloxane, polyglycerin-modified polysiloxane, polysilicone, methylhydrogen polysiloxane, methylphenyl polysiloxane, mercapto-modified silicone, linoleamidopropyl PG-dimonium chloride dimethicone, crosslinked organopolysiloxane, crosslinked silicone POA copolymer, crosslinked polyether-modified silicone, crosslinked polyglycerin-modified silicone, highly polymerized amino-modified silicone, highly polymerized dimethicone, highly polymerized dimethylsilicone, lowly polymerized dimethylsilicone, highly polymerized methylpolysiloxane, highly polymerized methylpolysiloxane emulsion, silicone polymer having a three-dimensional crosslinked structure, fatty acid-modified silicone, quaternary ammonium group-containing silylated urethane polymer, quaternary cation-modified silicone, long-chain alkyl-modified acrylate silicone, linear aminopolyether-modified silicone, linear aminopolyether-modified polysiloxane, silicone such as non-emulsifying crosslinked / partially crosslinked organopolysiloxane polymer silicone, etc.

[0029] Hydroxyalkylated cyclodextrins, hydroxypropyl cellulose, acylated pullulan, stearoxy hydroxypropyl methylcellulose, sugar derivatives such as trehalose isostearate, hyaluronic acid, acetylated hyaluronic acid, collagen, carboxymethyl chitosan succinamide, PPG-2 arginine, dilauroyl glutamate lysine Na, amidinoprolin, pyrrolidone carboxylic acids, glucosamines, moisturizers such as alanylglycine, glyceryl-N-(2-hydroxyethyl)carbamate, glucamines, etc., water-soluble moisturizing oils such as PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, lactones such as γ-dodecalactone, gluconolactone, erucalactone, cetyl 2-ethylhexanoate, di-2-heptylundecyl adipate, diglyceryl mixed fatty acid esters of adipic acid, isostearyl isostearate, octyldodecyl isostearate, phytosteryl isostearate, propylene glycol isostearate, isodecyl benzoate, isotridecyl isononanoate, isononyl isononanoate, polyglyceryl (eicosanedioic acid / tetradecanedioic acid), cetyl octanoate, ethyl oleate, phytosteryl oleate, di-2-ethylhexyl succinate, diethylhexyl succinate, bis(diethylene glycol ethyl ether) ester of succinic acid, diglyceryl diisostearate, propylene glycol dicaprylate, neopentyl glycol dicaprylate, tripropylene glycol dineopentanoate, esters of dipentaerythritol with mixed fatty acids such as hydroxystearic acid / stearic acid / rosin acid, di(phytostearyl / isostearyl / cetyl / stearyl / behenyl) dilinoleate, isocetyl stearate, stearyl stearate, hydrogenated castor oil stearate, diethyl sebacate, dextrin fatty acid ester, pentaerythrityl tetra-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, glyceryl tri(caprylate / caprate), glyceryl tri-2-ethylhexanoate, triethylhexanoin, isodecyl neopentanoate, isopropyl palmitate, ethylhexyl palmitate, octyl palmitate, hydrogenated castor oil hydroxystearate,Ester oils such as phytosteryl isostearate, isopropyl myristate, octyldodecyl myristate, myristyl myristate, diisostearyl malate, isopropyl lauroyl sarcosinate, lauroyl glutamate (phytosteryl / behenyl / octyldodecyl / isostearyl), dilauroyl glutamate (cholesteryl / behenyl / octyldodecyl), diisostearyl lauroyl glutamate, dioctyldodecyl lauroyl glutamate - 2, distearyl lauroyl glutamate - 2, dihexyldecyl lauroyl glutamate, acyl amino acid esters such as myristoyl methyl-β-alanine (phytosteryl / decyltetradecyl), branched fatty acids such as 18-methyl eicosanoic acid, 14-methyl pentadecanoic acid, 14-methyl hexadecanoic acid, 15-methyl hexadecanoic acid, 15-methyl heptadecanoic acid, 16-methyl heptadecanoic acid, 16-methyl octadecanoic acid, 17-methyl octadecanoic acid, 17-methyl nonadecanoic acid, and their ester oils, extracts from lanolin such as lanolin fatty acid and its salts, sphingosine, natural ceramides or natural - type ceramides, and their derivatives, hydrocarbon oils such as liquid paraffin, liquid isoparaffin, petrolatum, squalene, squalane, 2,2,4,6,6 - pentamethylheptane, proteins obtained from shells or pearls having nacre or their hydrolysates, proteins obtained from silk or their hydrolysates, thickeners, viscosity modifiers, lower alcohols such as ethanol, surfactant aids such as naphthalene sulfonic acid, emulsifiers, emulsifying agents, sequestering agents, ultraviolet absorbers, antioxidants such as nicotinamide, arginyl fructosyl glucose, tocopheryl retinoate, powder components, urethanes such as urethane resin, hydrophobically modified polyether urethane, polyurethane gel, blood circulation promoters, local irritants, anti - male hormone agents, anti - seborrheic agents, anti - aging agents, emollient agents, keratolytic agents, glycyrrhetinic acid, cholesterol, retinol, retinol acetate, retinol palmitate, menthol, alkoxysalicylic acid, salicylic acid, N - benzoyl glycylglycine, 1 - indanylidene derivatives, allantoin, glycosaminoglycans, polyglutamic acids, nicotinic acids, phosphoserine, trehalangin, tocopheryl phosphate, ascorbyl ethyl,Skin conditioning agents such as ascorbic acid-2-phosphate-6-fatty acid, whey, glycerophosphocholine, glucoheptonic acid, glyceryl-1-octadecylurethane, fungicides such as miconazole, preservatives such as methyl paraben and propyl paraben, anti-inflammatory agents, anti-inflammatory agents such as tranexamic acid, cooling agents, amino acids, vitamins such as tocopherol, ascorbic acid, glucopyranosyl ascorbic acid, vitamin derivatives, pH adjusters such as citric acid, malic acid, lactic acid, tartaric acid, glycolic acid, glucuronic acid, potassium hydroxide, sodium hydroxide, deep ocean water, pigments, fragrances such as benzyl alcohol, etc. can be mentioned.

[0030] The composition for improving skin barrier function after washing of the present invention exerts its effect by being added to a body cleanser and used. The addition amount of the composition for improving skin barrier function after washing to the body cleanser can be adjusted as appropriate.

Example

[0031] Regarding the effects of the present invention, it will be described in more detail by the following examples, but the present invention is not limited to these examples and the like. In the examples, unless otherwise specified, the components used were those purchased from Fujifilm Wako Pure Chemical Corporation.

[0032] Test method The composition for improving skin barrier function after washing having the composition shown in Tables 1 to 4 was prepared by the following method, and the composition for improving skin barrier function after washing described in Examples 1 to 16 and Comparative Examples 1 to 10 was obtained. The numerical values in the composition indicate the weight % of the pure component. The following evaluation was performed on the obtained composition for improving skin barrier function after washing. The results are shown in Tables 1 to 4.

[0033] Preparation of the composition for improving skin barrier function after washing After uniformly mixing components (A), (B), (C), and (D), the one adjusted to a total amount of 100% by weight using purified water was used as the composition for improving skin barrier function after washing.

[0034] Preparation of the sample for evaluation Potassium laurate, potassium myristate, potassium palmitate and purified water were uniformly mixed and then heated and dissolved at 80 °C. Then, it was cooled and adjusted so that the total amount became 100% by weight. Then, it was mixed with the skin barrier function improving composition after washing at a weight ratio of 1:1 to obtain the evaluation samples in Tables 1 and 2. Similarly, sodium lauryl sulfate and purified water were uniformly mixed and then heated and dissolved at 80 °C. Then, it was cooled and adjusted so that the total amount became 100% by weight. Then, it was mixed with the skin barrier function improving composition after washing at a weight ratio of 1:1 to obtain the evaluation samples in Tables 3 and 4.

[0035] Regarding the effect of improving the skin barrier function The effect of improving the skin barrier function described in this specification indicates suppressing an increase in the amount of trans-epidermal water loss (TEWL). TEWL was measured using a Tewameter TM300 (Courage and Khazaka electronic GmbH, Cologne, Germany). This is to calculate the amount of water evaporated from the skin surface by obtaining the vapor pressure by diffusion of water in the atmosphere based on Fick's law on the skin surface. That is, when the skin barrier function is deteriorated, the TEWL value becomes high. The unit of measurement of the TEWL value is g / h / m 2 is.

[0036] Evaluation method for the effect of improving the skin barrier function after washing As a measurement method, 10 in-house professional panelists who answered that they have sensitive skin in daily life were made to enter a measurement room with an environment of 22 ± 2°C at room temperature and 55 ± 5% humidity 30 minutes before the measurement, and were made to wait in a resting state. 3 g of the evaluation samples prepared in Examples 1 to 16 and Comparative Examples 1 to 10 was applied to the inner side of the left upper arm of the subject, and washing was performed by reciprocating 100 times up and down with the pulp of the finger. Thereafter, the moisture was wiped off, and the initial TEWL and the TEWL after 60 minutes were measured. At the time of measurement, measurement was performed for about 10 seconds until the numerical value became stable, and among the 5 measured values, the average value of 3 values excluding the maximum value and the minimum value was taken as the average value of 1 individual, and the average value for 10 persons was calculated. The effect of improving the skin barrier function after washing was calculated from the following formula (1) using the value (X) of TEWL immediately after washing and the measurement result (Y) of TEWL after 60 minutes. The larger the numerical value of the effect of improving the skin barrier function after washing, the higher the effect of improving the skin barrier function of the skin after washing. Formula (1) Effect of improving skin barrier function after washing (%) = (X - Y) / X × 100 As a calculation example, in the case of Example 1, X is 30.0 g / h / m 2 , Y is 8.0 g / h / m 2 and the effect of improving the skin barrier function after washing was 73.3%.

[0037] Evaluation method for skin irritation after washing and stickiness of skin after washing To 10 in-house professional panelists who answered that they have sensitive skin in daily life, 5 g of the evaluation samples prepared in Examples 1 to 16 and Comparative Examples 1 to 10 was foamed about 20 times with a nylon towel, the inner side of the left upper arm of the subject was washed, rinsed, and towel-dried. The skin irritation after washing and the stickiness of the skin after washing were evaluated according to the following criteria. The evaluation was based on the following criteria, and ranking was performed based on the average score of the evaluation points of 10 persons. <Skin irritation after washing> 4: No irritation is felt at all 3: Almost no irritation is felt 2: Irritation is felt 1: Strong irritation is felt The ranks were ◎: 4 to 3.5, ○: less than 3.5 to 3, △: less than 3 to 2, ×: less than 2 to 1. <Stickiness of skin after washing> 4: Do not feel any stickiness on the skin 3: Neither can be said 2: Slightly feel the stickiness of the skin 1: Strongly feel the stickiness of the skin The ranks were set as ◎: 4 - 3.5, ○: less than 3.5 - 3, △: less than 3 - 2, ×: less than 2 - 1.

[0038] Evaluation method for hue stability of skin barrier function improvement composition after washing 100 g of the evaluation samples prepared in Examples 1 - 16 and Comparative Examples 1 - 10 were collected and filled into a glass container (Asahi Glass Co., Ltd.: PS - 13K). The appearance was visually observed, and the initial hue was determined by the APHA value (Hazen unit color number). Then, the hue was determined by the APHA value after storage at 50°C for 4 weeks. The hue stability was calculated from the following formula (2) using the APHA value (X) immediately after preparation and the APHA value (Y) after storage at 50°C for 4 weeks. Formula (2) Hue change rate (%) = (Y - X) / X × 100 As a calculation example, in the case of Example 1, X was 10, Y was 10, and the hue change rate was 0%. Judgment was made according to the following evaluation criteria. <Evaluation criteria for hue stability> 〇: No change, hue change rate (%) 0 - 50% △: Colored, hue change rate (%) 51 - 100% ×: Significantly colored, hue change rate (%) 101 - 150%

[0039]

Table 1

[0040]

Table 2

[0041]

Table 3

[0042]

Table 4

[0043] Results Examples 1 to 16 prepared within the range of the skin barrier function-improving composition after washing of the present invention were excellent in the effect of improving the skin barrier function after body washing by the detergent used during body washing, and had low skin irritation after washing. Also, Examples 1 to 4, 8, 9 to 12, and 16 had no stickiness on the skin after washing. Also, Examples 1 to 7 and 9 to 15 were excellent in hue stability. On the other hand, in Comparative Example 1 without the component (A), the effect of improving the skin barrier function after washing was inferior, and there was skin irritation after washing. In Comparative Example 2 without the component (B), the effect of improving the skin barrier function after washing was inferior, and there was skin irritation after washing. In Comparative Example 3 without the component (C), the effect of improving the skin barrier function after washing was inferior, and there was skin irritation after washing. In Comparative Example 4 without the component (D), the effect of improving the skin barrier function after washing was inferior, and there was skin irritation after washing. In Comparative Example 5 without the components (A), (B), (C), and (D), the effect of improving the skin barrier function after washing was inferior, and there was skin irritation after washing. In Comparative Example 6 without the component (A), the effect of improving the skin barrier function after washing was inferior, and there was skin irritation after washing. In Comparative Example 7 without the component (B), the effect of improving the skin barrier function after washing was inferior, and there was skin irritation after washing. In Comparative Example 8 without the component (C), the effect of improving the skin barrier function after washing was inferior, and there was skin irritation after washing. In Comparative Example 9 without the component (D), the effect of improving the skin barrier function after washing was inferior, and there was skin irritation after washing. In Comparative Example 10 without the components (A), (B), (C), and (D), the effect of improving the skin barrier function after washing was inferior, and there was skin irritation after washing.

[0044] Example 17 Composition for improving skin barrier function after washing (added to amino acid-based body wash) The following composition for improving skin barrier function after washing and an amino acid-based body wash were prepared and mixed at a weight ratio of composition for improving skin barrier function after washing: amino acid-based body wash = 1:99, and their performance was evaluated. In the reduction of skin barrier function after body washing, it was excellent in the effect of improving the skin barrier function after washing, had low skin irritation after washing, no stickiness of the skin after washing, and excellent hue stability. The numerical values in the composition indicate the weight % of the pure component. Composition for improving skin barrier function after washing Sucinoyl arginine Na 0.5 wt% Glycerin 3.0 wt% Acrylates copolymer 0.3 wt% Chlorogenic acid (※7) 0.05 wt% Purified water balance (adjusted to 100 wt%) ※7: Reagent (Funakoshi), derived from coffee beans, purity 98% by weight Amino acid-based body cleanser Sodium lauroyl methyl alaninate (※8) 10.0% by weight Lauramidopropylamine oxide (※9) 6.0% by weight Lauramidopropyl betaine (※10) 2.0% by weight Cocamidomethyl MEA (※11) 2.0% by weight Hydroxypropyl methyl cellulose (※12) 0.1% by weight Citric acid appropriate amount Purified water balance (adjusted to 100% by weight) ※8: Alanone ALE (Kawaken Fine Chemicals), ※9: Softazoline LAO-C (Kawaken Fine Chemicals), ※10: Softazoline LPB (Kawaken Fine Chemicals), ※11: Aminon (registered trademark) C-11S (Kao), ※12: Methocel (registered trademark) 90SH-4000 (Shin-Etsu Chemical Co., Ltd.)

Industrial Applicability

[0045] The composition for improving skin barrier function after washing according to the present invention can be used as a composition for improving skin barrier function after washing in body soaps, body shampoos, body washes, soaps, facial cleansers, makeup removers, cleansing foams, cleansing creams, cleansing lotions, hand soaps, hand cleaners, hand washes, hand cleansers, finger cleansers, toe cleansers, local cleansers and other body cleansers, and scalp cleansers.

Claims

1. (A)Succinoyl arginine represented by formula (1) or a salt thereof 【Chemical 1】 (B)At least one selected from polyols having 1 to 15 carbon atoms and 2 to 11 oxygen atoms (C)As a film-forming polymer, at least one of a homopolymer or copolymer having as monomer units vinyl pyrrolidone, dimethyldiallylammonium chloride, acrylic acid, methacrylic acid, their esters or amides (D)Catechins derived from green tea is a composition of A composition for improving skin barrier function after washing, wherein the content of the component (A) is 0.1 to 2.0% by weight.

2. The composition for improving skin barrier function after washing according to claim 1, wherein the content of the component (B) in the composition for improving skin barrier function after washing is 1.0 to 10.0% by weight.

3. The composition for improving skin barrier function after washing according to claim 1 or 2, wherein the content of the component (C) in the composition for improving skin barrier function after washing is 0.05 to 1.0% by weight.

4. The composition for improving skin barrier function after washing according to any one of claims 1 to 3, wherein the content of the component (D) in the composition for improving skin barrier function after washing is 0.0001 to 0.1% by weight.

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