Semi-permanent tattoo

Abstract

The present disclosure relates to semi-permanent tattoos, and more specifically to genipin-based ink compositions, and layered adhesive articles and methods for applying genipin-based semi-permanent tattoos. In some embodiments, the genipin-based ink compositions include purified genipin present in an amount of about 5% to about 10% w / w of the composition, one or more volatile solvents present in an amount of about 70% to about 85% w / w of the composition, one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 10% to about 20% w / w of the composition, and one or more surfactants present in an amount of about 0.25% to about 5% w / w of the composition.

Description

Technical Field

[0001] Cross - Reference to Related Applications This application claims the benefit of U.S. Provisional Application No. 62 / 802,688, filed Feb. 7, 2019, and U.S. Provisional Application No. 62 / 863,560, filed Jun. 19, 2019. The disclosures of the prior applications are incorporated herein by reference in their entirety.

[0002] Technical Field The present invention relates to semi - permanent tattoos, and more specifically, to genipin - based ink compositions, as well as to laminated adhesive articles and methods for applying genipin - based semi - permanent tattoos.

Background Art

[0003] Temporary or semi - permanent tattoos or body inks have been used throughout human history to adorn the body. Generally, temporary or semi - permanent tattoos are transferred to the skin by directly exposing the skin to tattoo ink for a specified latency period. The quality of the transferred image and its duration on the skin can depend on the ink distribution profile in the outer layer of the skin called the stratum corneum. Current manufacturing processes for existing tattoo designs include the use of flexographic or gravure printing, stencils, and inkjet printers. However, due to the barrier properties of the stratum corneum, many of the current methods require moderate monitoring by the end - user during the tattoo application process to ensure proper ink delivery to the skin so that the tattoo ink develops color properly.

Summary of the Invention

[0004] Disclosed herein is an ink composition comprising one or more semi - permanent colorants, one or more volatile solvents, and one or more semi - volatile semi - permanent colorant solubilizers.

[0005] In some embodiments, the ink composition has a viscosity of about 1 to about 20 centipoise. In some embodiments, the ink composition has a viscosity of about 1 to about 7 centipoise. In some embodiments, the ink composition is configured to have a viscosity of about 1 to about 7 centipoise. In some embodiments, the ink composition has a viscosity of about 3 to about 7 centipoise. In some embodiments, the ink composition is configured to have a viscosity of about 3 to about 7 centipoise. In some embodiments, the ink composition is configured to have a surface tension of about 20 to about 35 dynes / cm. In some embodiments, the ink composition has a surface tension of about 20 to about 35 dynes / cm.

[0006] In some embodiments, the semi-permanent colorant is present in an amount of about 0.1% to about 20% w / w of the composition. In some embodiments, one or more semi-permanent colorants are present in an amount of about 5% to about 15% w / w of the composition. In some embodiments, one or more semi-permanent colorants are present in an amount of about 5% to about 10% w / w of the composition. In some embodiments, one or more semi-permanent colorants are present in an amount of about 7% to about 11% w / w of the composition. In some embodiments, one or more semi-permanent colorants are present in an amount of about 6% to about 8% w / w of the composition. In some embodiments, one or more semi-permanent colorants are present in an amount of about 9% w / w of the composition. In some embodiments, one or more semi-permanent colorants are present in an amount of about 7% w / w of the composition.

[0007] In some embodiments, one or more semi-permanent colorants are colorant precursors such as genipin. In some embodiments, genipin is purified genipin.

[0008] In some embodiments, one or more volatile solvents are present in an amount of about 0.1% to about 95% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 60% to about 90% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 60% to about 80% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 65% to about 85% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 70% to about 80% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 50% to about 75% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 65% to about 75% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 65% to about 70% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 70% to about 75% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 75% to about 80% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 77% w / w of the composition. In some embodiments, one or more volatile solvents are selected from the group consisting of water, methanol, ethanol, isopropanol, and combinations of two or more thereof.

[0009] In some embodiments, one or more volatile solvents are a combination of water and ethanol. In some embodiments, water is present in an amount of about 40% to about 55% w / w of the composition and ethanol is present in an amount of about 15% to about 30% w / w of the composition. In some embodiments, water is present in an amount of about 45% to about 50% w / w of the composition and ethanol is present in an amount of about 20% to about 27% w / w of the composition. In some embodiments, water is present in an amount of about 25% to about 35% w / w of the composition and ethanol is present in an amount of about 35% to about 50% w / w of the composition. In some embodiments, water is present in an amount of about 30% w / w of the composition and ethanol is present in an amount of about 43% w / w of the composition.

[0010] In some embodiments, one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 0.1% to about 95% w / w of the composition. In some embodiments, one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 0.1% to about 25% w / w of the composition. In some embodiments, one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 15% to about 25% w / w of the composition. In some embodiments, one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 10% to about 20% w / w of the composition. In some embodiments, one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 20% to about 25% w / w of the composition. In some embodiments, one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 15% w / w of the composition. In some embodiments, one or more semi-volatile semi-permanent colorant solubilizers are selected from the group consisting of polyethylene glycol, alkyl glycol, alkylene glycol ether, and combinations of two or more thereof. In some embodiments, the alkyl glycol is diethylene glycol monoethyl ether. In some embodiments, one or more semi-volatile semi-permanent colorant solubilizers are diethylene glycol monoethyl ether.

[0011] In some embodiments, the composition further comprises one or more surfactants. In some embodiments, the one or more surfactants are present in an amount of about 0.1% to about 5% w / w of the composition. In some embodiments, the one or more surfactants are present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the one or more surfactants are present in an amount of about 2% w / w of the composition. In some embodiments, the one or more surfactants are selected from the group consisting of alkylbenzene sulfonate, alkyl sulfate, alkyl ether sulfate, alkyl alcohol, soap, ethoxylate, lignosulfonate, and triglyceride. In some embodiments, the one or more surfactants are selected from the group consisting of sodium dodecylbenzene sulfonate, lauryl sulfate, dialkyl sulfosuccinate, dimethyl ether of tetradecylphosphonic acid, lauryl monoethanol, glycerol diester (diglyceride), dodecyl betaine, abietic acid, polyethoxylated octylphenol, 1,2 - hexanediol, and sorbitan monoester. In some embodiments, the one or more surfactants are 1,2 - hexanediol.

[0012] In some embodiments, the composition further comprises one or more matrix components. In some embodiments, the composition further comprises one or more matrix components. In some embodiments, the one or more matrix components are present in an amount of about 0.1% to about 10% w / w of the composition. In some embodiments, the one or more matrix components are present in an amount of about 0.1% to about 3% w / w of the composition. In some embodiments, the one or more matrix components are present in an amount of about 2% w / w of the composition. In some embodiments, the one or more matrix components are selected from the group consisting of sugars, sugar alcohols, and polymers. In some embodiments, the sugar is selected from the group consisting of trehalose, glucose, fructose, galactose, ribose, and xylose, trehalose, sucrose, lactotrehalose, galactotrehalose, 6-azidotrehalose, maltose, lactose, lactulose, cellobiose, chitobiose, starch, glycogen, cellulose, and chitin. In some embodiments, the sugar is trehalose. In some embodiments, the one or more matrix components is trehalose. In some embodiments, the one or more matrix components is hydroxypropylmethylcellulose. In some embodiments, the composition further comprises one or more skin penetration enhancers. In some embodiments, the one or more skin penetration enhancers are present in an amount of about 0.1% to about 50% w / w of the composition. In some embodiments, the one or more skin penetration enhancers are present in an amount of about 0.5% to about 5% w / w of the composition. In some embodiments, the one or more skin penetration enhancers are selected from the group consisting of alcohols, amides, esters, ether alcohols, fatty acids, glycols, pyrrolidones, sulfoxides, surfactants, and terpenes.In some embodiments, one or more skin penetration enhancers are selected from the group consisting of ethanol, isopropanol, decanol, hexanol, lauryl alcohol, myristyl alcohol, octanol, octyldodecanol, oleyl alcohol, azone, ethyl acetate, octyl salicylate, padimate O, ethyl oleate, glyceryl monooleate, glyceryl monocaprylate, glyceryl tricaprylate, isopropyl myristate, isopropyl palmitate, propylene glycol monolaurate, propylene glycol monocaprylate, diethylene glycol monoethyl ether (TRANSCUTOL®), lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, stearic acid, isostearic acid, dipropylene glycol, propylene glycol, 1,2 - butylene glycol, 1,3 - butylene glycol, n - methyl - 2 - pyrrolidone, 2 - pyrrolidone, decyl methyl sulfoxide, dimethyl sulfoxide, sodium lauryl sulfate, alkyldimethylbenzylammonium halide, alkyltrimethylammonium halide, alkylpyridinium halide, brij 36t, polyethylene glycol sorbitan monooleate (e.g., TWEEN® 80), eugenol, D - limonene, menthol, menthone, farnesol, and neridol.

[0013] In some embodiments, the composition further comprises one or more temporary colorants. In some embodiments, the one or more temporary colorants are present in an amount of about 0.1% to about 1% w / w of the composition. In some embodiments, the one or more temporary colorants are present in an amount of about 0.3% w / w of the composition.In some embodiments, one or more temporary colorants are selected from the group consisting of iron black oxide (Fe3O4), iron oxide (FeO), carbon, logwood, loess, cinnabar (HgS), cadmium red (CdSe), iron(III) oxide (Fe2O3), naphthol-AS pigments, disazo diarylide, disazo pyrazolone, cadmium selenosulfide, cadmium yellow (CdS, CdZnS), curcuma yellow, chrome yellow (PbCrO4), disazo diarylide, chromium oxide (Cr2O3), malachite [Cu2(CO3)(OH)2], ferrocyanide, ferricyanide, lead chromate, monoazo pigments, Cu / Al phthalocyanine, Cu phthalocyanine, azur blue, cobalt blue, Cu-phthalocyanine, manganese violet (ammonium manganese pyrophosphate), aluminum salts, quinacridone, dioxazine / carbazole, lead white (lead carbonate), titanium dioxide (TiO2), barium sulfate (BaSO4), zinc oxide, anthraquinone dyes and derivatives, anato, caramel, β-carotene, bismuth citrate, disodium EDTA copper, potassium sodium copper chlorophyllin, dihydroxyacetone, bismuth oxy chloride, guaiac azulene, henna, ammonium iron ferrocyanide, iron ferrocyanide, chromium hydroxide green, chromium oxide green, guanine, lead acetate, pyrophyllite, mica, silver, titanium dioxide, aluminum powder, bronze powder, copper powder, ultramarine, manganese violet, zinc oxide, luminescent zinc sulfide, D&C Black No. 2 and 3, FD&C Blue No. 1 (e.g., Acid Blue 9), D&C Blue No. 4, D&C Brown No. 1, FD&C Green No. 3, D&C Green No. 5, 6 and 8, D&C Orange No. 4, 5, 10 and 11, FD&C Red No. 4, D&C Red No. 6, 7, 17, 21, 22, 27, 28, 30, 32, 33, 34, 36, and 40, D&C Violet No. 2, Ext.D&C Violet No. 2, FD&C Yellow No. 5 and 6, D&C Yellow No. 7, 8, 10 and 11, and Ext.D&C Yellow No. 7. In some embodiments, the temporary colorant does not contain an amine group. In some embodiments, the temporary colorant is Acid Blue 9.

[0014] In some embodiments, the ink composition has a pH of from about 3 to about 8. In some embodiments, the ink composition has a pH of from about 4 to about 7. In some embodiments, the ink composition has a pH of from about 4.5 to about 5. In some embodiments, the ink composition has a pH of from about 4.8 to about 5. In some embodiments, the ink composition has a pH of about 4.9. In some embodiments, the ink composition has a pH of about 4.6.

[0015] In some embodiments, the ink composition is configured to have a pH of from about 3 to about 8. In some embodiments, the ink composition is configured to have a pH of from about 4 to about 7. In some embodiments, the ink composition is configured to have a pH of from about 4.8 to about 5. In some embodiments, the ink composition is configured to have a pH of about 4.9.

[0016] In some embodiments, the ink composition further comprises one or more preservatives. In some embodiments, the one or more preservatives are present in an amount of about 0.5% to about 1.5% w / w of the composition. In some embodiments, the one or more preservatives are present in an amount of about 1% w / w of the composition. In some embodiments, the one or more preservatives are ascorbic acid, ascorbate, palmitate, citric acid, benzoate, benzoic acid, propionate, propionic acid, sorbate, sorbic acid, salicylic acid, salicylate, hex-2,4-dienoic acid, hex-2,4-dienoate, formaldehyde, formaldehyde releaser, formic acid and its salts, 3-acetyl-6-methylpyran-2,4-(3H)-dione and its salts, 3,3'-dibromo-4,4'-hexamethylenedioxydibenzamidine and its salts, thimerosal, phenylmercury salts, undec-10-enoic acid and its salts, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-5-pyrimidine, 5-bromo-5-nitro-1,3-dioxane, bronopol, 2,4-dichlorobenzyl alcohol, 1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea, chlorocresol, chloroxylenol, 5-chloro-2-(2,4-dichlorophenoxy)phenol, N,N”-methylenebis[N’-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea], polyaminopropylbiguanide, methenamine, quaternium-15, climbazole, DMDM hydantoin, benzyl alcohol, 1-hydroxy-4-methyl-6-(2,4,Selected from the group consisting of 4-(trimethylpentyl)-2-pyridone, piroctone olamine, bromochlorophene, o-cymen-5-ol, chlorophene, chloroacetamide, methylchloroisothiazolinone, methylisothiazolinone, phenoxyisopropanol, chlorhexidine, chlorhexidine diacetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, dimethyloxazolidine, behentrimonium chloride, cetrimonium bromide, cetrimonium chloride, laurtrimonium bromide, laurtrimonium chloride, steartrimonium bromide, steartrimonium chloride, diazolidinyl urea, hexamidine, hexamidine diisethionate, hexamidine parabens, glutaral, 7-ethylbicyclooxazolidine, chlorphenesin, hydroxymethylglycine sodium, silver chloride, benzethonium chloride, benzalkonium chloride, benzalkonium bromide, benzalkonium saccharinate, benzyl hemiformal, iodopropynyl butylcarbamate, biphenyl-2-ol and its salts, zinc pyrithione, erythorbate, nitrous acid, ethylenediaminetetraacetic acid (EDTA), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), capric acid, dilauryl thiodipropionate, erythorbic acid, guaiac resin, methylparaben, sulfite, bisulfite, metabisulfite, propyl gallate, propylparaben, stannous chloride, sulfur dioxide, thiodipropionic acid, isothiazoline, parabens, phenoxyethanol, ethylhexylglycerin, glycol, and tocopherol. In some embodiments, one or more preservatives are phenoxyethanol and ethylhexylglycerin.,

[0017] As used herein, there is also provided an ink composition comprising purified genipin present in an amount of about 5% to about 10% w / w of the composition, one or more volatile solvents present in an amount of about 70% to about 85% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, one or more volatile solvents, one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 10% to about 20% w / w of the composition and being diethylene glycol monoethyl ether, one or more surfactants present in an amount of about 0.25% to about 5% w / w of the composition, and one or more matrix components present in an amount of about 0.1% to about 5% w / w of the composition.

[0018] As used herein, there is also provided an ink composition comprising purified genipin present in an amount of about 7% w / w of the composition, one or more volatile solvents present in an amount of about 65% to about 70% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, one or more volatile solvents, one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 10% to about 20% w / w of the composition and comprising diethylene glycol monoethyl ether, one or more surfactants present in an amount of about 1% to about 3% w / w of the composition, and one or more matrix components present in an amount of about 1% to about 3% w / w of the composition.

[0019] As used herein, there is also provided an ink composition comprising purified genipin present in an amount of about 7% w / w of the composition, one or more volatile solvents present in an amount of about 77% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, one or more volatile solvents, one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 15% w / w of the composition and comprising diethylene glycol monoethyl ether, one or more surfactants present in an amount of about 2% w / w of the composition, and one or more matrix components present in an amount of about 2% w / w of the composition.

[0020] In some embodiments, water is present in an amount of about 25% to about 35% w / w of the composition, and ethanol is present in an amount of about 40% to about 45% w / w of the composition. In some embodiments, water is present in an amount of about 30% w / w of the composition, and ethanol is present in an amount of about 43% w / w of the composition.

[0021] In some embodiments, the one or more surfactants are diethylene glycol monoethyl ether. In some embodiments, the one or more matrix components are trehalose.

[0022] In some embodiments, the composition further comprises one or more preservatives. In some embodiments, the one or more preservatives are present in an amount of about 0.5% to about 1.5% w / w of the composition. In some embodiments, the one or more preservatives are present in an amount of about 1% w / w of the composition. In some embodiments, the one or more preservatives are phenoxyethanol and ethylhexylglycerin.

[0023] In some embodiments, the composition has a viscosity of about 1 to about 7 centipoises. In some embodiments, the composition has a viscosity of about 3 to about 7 centipoises. In some embodiments, the composition has a surface tension of about 20 to about 35 dynes / cm.

[0024] In some embodiments, the composition is an ink composition for an inkjet printer.

[0025] Also provided herein is an ink composition for an inkjet printer comprising purified genipin, one or more volatile solvents, and one or more semi-volatile semi-permanent colorant solubilizers. In some embodiments, the composition is configured to have a viscosity of about 1 to about 7 centipoise. In some embodiments, the composition is configured to have a viscosity of about 3 to about 7 centipoise. In some embodiments, the composition is configured to have a surface tension of about 20 to about 35 dynes / cm. In some embodiments, the composition further comprises one or more skin penetration enhancers. In some embodiments, the composition further comprises one or more temporary colorants.

[0026] In some embodiments, the ink composition for an inkjet printer is configured to have a pH of about 3 to about 8. In some embodiments, the composition is configured to have a pH of about 4 to about 7. In some embodiments, the composition is configured to have a pH of about 4.8 to about 5. In some embodiments, the composition is configured to have a pH of about 4.9.

[0027] Also provided herein is an ink composition for an inkjet printer comprising purified genipin present in an amount of about 7% to about 11% w / w of the composition, one or more volatile solvents present in an amount of about 60% to about 80% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 10% to about 30% w / w of the composition and being diethylene glycol monoethyl ether, one or more surfactants present in an amount of about 0.25% to about 5% w / w of the composition, and one or more matrix components present in an amount of about 0.1% to about 5% w / w of the composition.

[0028] In some embodiments, the one or more surfactants are PEG400. In some embodiments, the one or more matrix components are trehalose.

[0029] In some embodiments, the ink composition of an inkjet printer further comprises one or more temporary colorants. In some embodiments, the temporary colorant is present in an amount of about 0.05% to about 0.25% w / w of the composition. In some embodiments, the one or more temporary colorants is FD&C Blue No. 1. Also provided herein is an ink composition for an inkjet printer comprising purified genipin present in an amount of about 7% to about 11% w / w of the composition, one or more volatile solvents present in an amount of about 65% to about 75% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 15% to about 25% w / w of the composition and comprising diethylene glycol monoethyl ether, one or more surfactants present in an amount of about 0.25% to about 5% w / w of the composition, and one or more matrix components present in an amount of about 0.5% to about 3.5% w / w of the composition.

[0030] In some embodiments, the one or more surfactants is PEG400. In some embodiments, the one or more matrix components is trehalose.

[0031] In some embodiments, the ink composition of an inkjet printer further comprises one or more temporary colorants. In some embodiments, the temporary colorant is present in an amount of about 0.05% to about 0.25% w / w of the composition. In some embodiments, the one or more temporary colorants is FD&C Blue No. 1. Also provided herein is an ink composition for an inkjet printer comprising purified genipin present in an amount of about 9% w / w of the composition, one or more volatile solvents present in an amount of about 67% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 21% w / w of the composition and being diethylene glycol monoethyl ether, one or more surfactants present in an amount of about 1% w / w of the composition, and one or more matrix components present in an amount of about 2% w / w of the composition.

[0032] In some embodiments, the one or more surfactants are PEG400. In some embodiments, the one or more matrix components are trehalose.

[0033] Also provided herein is an ink composition for an inkjet printer, comprising genipin present in an amount of about 9% w / w of the composition, one or more volatile solvents present in an amount of about 66.6% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 21% w / w of the composition and being diethylene glycol monoethyl ether, one or more surfactants present in an amount of about 1% w / w of the composition, one or more matrix components present in an amount of about 2% w / w of the composition, and one or more temporary colorants present in an amount of about 0.2% w / w of the composition.

[0034] In some embodiments, the one or more surfactants are PEG400. In some embodiments, the one or more matrix components are trehalose. In some embodiments, the one or more temporary colorants are FD&C Blue No. 1. Also provided herein is an ink composition for an inkjet printer, comprising genipin present in an amount of about 2% to about 5% w / w of the composition, one or more volatile solvents present in an amount of about 65% to about 75% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 15% to about 25% w / w of the composition and comprising diethylene glycol monoethyl ether, one or more surfactants present in an amount of about 0.25% to about 5% w / w of the composition, one or more matrix components present in an amount of about 0.5% to about 3.5% w / w of the composition, and one or more temporary colorants present in an amount of about 0.2% w / w of the composition.

[0035] In some embodiments, one or more surfactants are PEG400. In some embodiments, one or more matrix components are trehalose. In some embodiments, one or more temporary colorants are FD&C Blue No. 1.

[0036] Also provided herein is an ink composition for an inkjet printer comprising purified genipin present in an amount of about 4.5% w / w of the composition, one or more volatile solvents present in an amount of about 70% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 22.5% w / w of the composition and being diethylene glycol monoethyl ether, one or more surfactants present in an amount of about 1% w / w of the composition, one or more matrix components present in an amount of about 2% w / w of the composition, and one or more temporary colorants present in an amount of about 0.1% w / w of the composition.

[0037] In some embodiments, one or more surfactants are PEG400. In some embodiments, one or more matrix components are trehalose. In some embodiments, one or more temporary colorants are FD&C Blue No. 1.

[0038] Also provided herein is a skin priming composition comprising one or more volatile solvents, one or more amines, and one or more humectants.

[0039] In some embodiments of the skin priming composition, one or more volatile solvents are selected from the group consisting of water, methanol, ethanol, isopropanol, and combinations of two or more thereof. In some embodiments of the skin priming composition, one or more volatile solvents are present in an amount of about 80% to about 98% w / w of the composition. In some embodiments of the skin priming composition, one or more volatile solvents are present in an amount of about 92% to about 96% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 90% to about 95% w / w of the composition. In some embodiments, one or more volatile solvents are present in an amount of about 93% w / w of the composition.

[0040] In some embodiments of the skin priming composition, one or more amines are selected from the group consisting of arginine, alanine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, δ-aminolevulinic acid, 4-aminobenzoic acid, and γ-aminobutyric acid. In some embodiments of the skin priming composition, one or more amines are L-arginine. In some embodiments of the skin priming composition, one or more amines are present in an amount of about 0.5% to about 2% w / w of the composition. In some embodiments of the skin priming composition, one or more amines are present in an amount of about 0.5% to about 1% w / w of the composition. In some embodiments, one or more amines are present in an amount of about 0.5% to about 2% w / w of the composition. In some embodiments, one or more amines are present in an amount of about 1% w / w of the composition.

[0041] In some embodiments of the skin priming composition, one or more humectants are selected from the group consisting of glycerin, glycerin, propylene glycol, polyethylene glycol, sugars, hexylene glycol, butylene glycol, aloe vera gel, alpha-hydroxy acids such as lactic acid, glyceryl triacetate, lithium chloride, sorbitol, xylitol, maltitol, hyaluronic acid, allantoin, urea, tremella extract, dicyandiamide, sodium lactate, and sodium L-pyroglutamate. In some embodiments, one or more amines is L-arginine.

[0042] In some embodiments of the skin priming composition, one or more humectants are present in an amount of about 1% to about 10% w / w of the composition. In some embodiments of the skin priming composition, one or more humectants are present in an amount of about 5% w / w of the composition. In some embodiments, one or more humectants are present in an amount of about 1% to about 10% w / w of the composition. In some embodiments, one or more humectants are present in an amount of about 5% w / w of the composition.

[0043] In some embodiments, one or more humectants are selected from the group consisting of glycerin, glycerol, propylene glycol, polyethylene glycol, sugars, hexylene glycol, butylene glycol, aloe vera gel, alpha-hydroxy acids such as lactic acid, glyceryl triacetate, lithium chloride, sorbitol, xylitol, maltitol, hyaluronic acid, allantoin, urea, tremella extract, dicyandiamide, sodium lactate, and sodium L-pyroglutamate. In some embodiments of the skin priming composition, one or more humectants are glycerin. In some embodiments, the skin priming composition further comprises one or more preservatives. In some embodiments, one or more preservatives are present in an amount of about 0.5% to about 1.5% w / w of the composition. In some embodiments, one or more preservatives are present in an amount of about 1% w / w of the composition. In some embodiments, one or more preservatives are ascorbic acid, ascorbate, palmitate, citric acid, benzoate, benzoic acid, propionate, propionic acid, sorbate, sorbic acid, salicylic acid, salicylate, hex-2,4-dienoic acid, hex-2,4-dienoate, formaldehyde, formaldehyde-releasing agents, formic acid and its salts, 3-acetyl-6-methylpyran-2,4-(3H)-dione and its salts, 3,3'-dibromo-4,4'-hexamethylenedioxydibenzamidine and its salts, thimerosal, phenylmercury salts, undec-10-enoic acid and its salts, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-5-pyrimidine, 5-bromo-5-nitro-1,3-dioxane, bronopol, 2,4-dichlorobenzyl alcohol, 1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea, chlorocresol, chloroxylenol, 5-chloro-2-(2,4-dichlorophenoxy)phenol, N,N”-methylenebis[N’-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea], polyaminopropylbiguanide, methenamine, quaternium-15, climbazole, DMDM hydantoin, benzyl alcohol, 1-hydroxy-4-methyl-6-(2,4,Selected from the group consisting of 4-trimethylpentyl)-2-pyridone, piroctone olamine, bromochlorophen, o-cymen-5-ol, chlorophen, chloroacetamide, methylchloroisothiazolinone, methylisothiazolinone, phenoxyisopropanol, chlorhexidine, chlorhexidine diacetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, dimethyloxazolidine, behentrimonium chloride, cetrimonium bromide, cetrimonium chloride, laurtrimonium bromide, laurtrimonium chloride, steartrimonium bromide, steartrimonium chloride, diazolidinyl urea, hexamidine, hexamidine diisethionate, hexamidine parabens, glutaral, 7-ethylbicyclooxazolidine, chlorphenesin, sodium hydroxymethylglycinate, silver chloride, benzethonium chloride, benzalkonium chloride, benzalkonium bromide, benzalkonium saccharinate, benzyl hemiformal, iodopropynyl butylcarbamate, biphenyl-2-ol and salts thereof, zinc pyrithione, erythorbate, nitrous acid, ethylenediaminetetraacetic acid (EDTA), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), capric acid, dilauryl thiodipropionate, erythorbic acid, guaiac resin, methylparabens, sulfite, bisulfite, metabisulfite, propyl gallate, propylparabens, stannous chloride, sulfur dioxide, thiodipropionic acid, isothiazoline, parabens, phenoxyethanol, ethylhexylglycerin, glycol, and tocopherol. In some embodiments, one or more preservatives are phenoxyethanol and ethylhexylglycerin.,

[0044] In some embodiments, the skin priming composition has a pH of from about 4 to about 7. In some embodiments, the skin priming composition has a pH of from about 4.5 to about 5.5.,

[0045] In some embodiments of the skin priming composition, the skin priming composition further comprises one or more semi-volatile semi-permanent colorant solubilizers. In some embodiments of the skin priming composition, the one or more semi-volatile semi-permanent colorant solubilizers are selected from the group consisting of polyethylene glycol, alkyl glycol, alkylene glycol ether, and combinations of two or more thereof. In some embodiments of the skin priming composition, the one or more semi-volatile semi-permanent colorant solubilizers are diethylene glycol monoethyl ether. In some embodiments of the skin priming composition, the one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 50% to about 90% w / w of the composition.

[0046] In some embodiments of the skin priming composition, the skin priming composition further comprises one or more skin penetration enhancers.

[0047] In some embodiments of the skin priming composition, the skin priming composition has a pH of about 4 to about 7. In some embodiments of the skin priming composition, the skin priming composition has a pH of about 4.5 to about 5.5. In some embodiments of the skin priming composition, the skin priming composition is configured to have a pH of about 4 to about 7. In some embodiments of the skin priming composition, the skin priming composition is configured to have a pH of about 4.5 to about 5.5.

[0048] Also provided herein are towelettes comprising any of the skin priming compositions described herein.

[0049] Also provided herein are adhesive applicator articles that include an ink composition, such as any of the ink compositions described herein, an adhesive, and an adhesive backing. In some embodiments, the ink composition is disposed and / or bonded on a first surface of the adhesive, and the adhesive backing is disposed and / or bonded on a second surface of the adhesive. In some embodiments, the ink composition is printed on the first surface of the adhesive by an inkjet printer.

[0050] In some embodiments, the adhesive applicator article further includes a liner. In some embodiments, the liner is composed of a non-adhesive material.

[0051] In some embodiments, the adhesive backing is composed of a transparent material.

[0052] In some embodiments, the adhesive applicator article further includes a closure patch.

[0053] In some embodiments, the dimensions of the closure patch are larger than another dimension corresponding to the adhesive, and the closure patch surrounds the adhesive, the composition, or both.

[0054] Also provided herein are adhesive applicator articles that include an ink composition, such as any of the ink compositions described herein, a first adhesive layer, a first backing, a second adhesive layer, and a second backing. In some embodiments, an ink composition, such as any of the ink compositions described herein, is disposed and / or bonded on a first surface of the first adhesive layer, and the first backing is disposed and / or bonded on a second surface of the first adhesive layer. In some embodiments, the second adhesive layer is disposed and / or bonded on a second surface of the first backing.

[0055] In some embodiments, the first surface of the second backing is disposed and / or bonded on a second surface of the second adhesive layer.

[0056] In some embodiments, the second adhesive layer and the second backing are disposed and / or bonded to at least a portion of the second surface of the first backing.

[0057] In some embodiments, the ink composition is disposed and / or bonded to at least a portion of the first surface of the first adhesive layer. In some embodiments, the ink composition is printed on the first surface of the first adhesive by an inkjet printer.

[0058] In some embodiments, the adhesive applicator article further includes a liner. In some embodiments, the liner is disposed and / or bonded on the ink composition. In some embodiments, the liner is disposed and / or bonded on the ink composition and the first surface of the first adhesive, and the ink composition is disposed and / or bonded to a portion of the first surface of the first adhesive layer.

[0059] In some embodiments, the adhesive applicator article further includes a closure patch. In some embodiments, the dimensions of the closure patch are larger than other dimensions corresponding to the first adhesive, the second adhesive, or both.

[0060] In some embodiments, the liner is composed of a non-adhesive material.

[0061] In some embodiments, the first backing, the second backing, or both are composed of a transparent material. In some embodiments, the first adhesive layer, the second adhesive layer, or both are composed of a double-sided adhesive material.

[0062] Also provided herein is an adhesive applicator article including a liner, an adhesive layer for bonding to the liner, a stack-up for contacting the adhesive layer, a removable liner for contacting the stack-up, and a border for supporting the stack-up.

[0063] In some embodiments, the removable liner exposes the stack-up to the ambient environment when removed from the adhesive applicator article. In some embodiments, the removable liner further includes a pull tab to facilitate removal of the liner. In some embodiments, the liner is made of a material that includes fluorosilicone (FS).

[0064] In some embodiments, the boundary is made of a material that includes fluorosilicone (FS). In some embodiments, the boundary is made of a material that includes fluorosilicone (FS) and is part of the closure patch.

[0065] In some embodiments, the dimensions of the closure patch are larger than another dimension corresponding to the stack-up. In some embodiments, the stack-up includes different adhesive layers, a double-sided adhesive, and a polyurethane layer.

[0066] In some embodiments, the adhesive article further includes an ink composition, such as any of the ink compositions described herein. In some embodiments, the ink composition is printed on the stack-up by an inkjet printer.

[0067] Also provided herein is an adhesive applicator article that includes an outer layer positioned on a plurality of panels, one or more tabs coupled to the plurality of panels, and an end of the outer layer for receiving the one or more tabs.

[0068] In some embodiments, each of the plurality of panels includes an ink composition, such as any of the ink compositions described herein, an adhesive layer, and a backing.

[0069] In some embodiments, each of the plurality of panels is angled at a distance from different adjacent panels of the plurality of panels. In some embodiments, the distance between each of the plurality of panels is the same distance. In some embodiments, one or more tabs are perpendicular to the plurality of panels.

[0070] As used herein, there is also provided an adhesive applicator article positioned over any of the ink compositions described herein, such as an outer layer, a first portion of the outer layer, and a second portion of the outer layer, and including a first side of the first portion and a second side of the first portion.

[0071] In some embodiments, each of the plurality of panels includes an adhesive layer and a backing.

[0072] In some embodiments, the ink composition is printed over the adhesive layer by an inkjet printer.

[0073] In some embodiments, the first side of the first portion and the second side of the first portion are flexible and joined together. In some embodiments, the second portion is perpendicular to the first portion. In some embodiments, the second portion includes one or more curved portions.

[0074] In some embodiments, the one or more curved portions are curved with different radii of curvature.

[0075] In some embodiments, the ink composition forms a pattern over the first portion. In some embodiments, the ink composition forms a pattern over the second portion. In some embodiments, the ink composition forms a pattern over the first portion and the second portion.

[0076] In some embodiments, the outer layer is made of a transparent material.

[0077] As used herein, there is also provided a kit including any of the adhesive applicator articles described herein and any of the skin priming compositions described herein.

[0078] As used herein, there is also provided a kit including a toilet including any of the adhesive applicator articles described herein and any of the skin priming compositions described herein.

[0079] Details of one or more embodiments of the present invention are set forth in the accompanying drawings and the following description. Other features, objects, and advantages of the invention will become apparent from the description, drawings, and claims.

Brief Description of the Drawings

[0080]

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Embodiments for Carrying Out the Invention

[0081] Detailed Description By adopting a manufacturing approach that directly uses inkjet printing on a skin transfer substrate, it becomes possible to rapidly manufacture customized semi-permanent tattoos designed to order. However, inkjet printing may impose constraints on the physicochemical properties of the ink ejected from the printer nozzles. Furthermore, the ink vehicle should be formulated such that the ink printed on the transfer substrate is safe for contact with the skin and maintains stability or skin transferability during the product's shelf life. The lifespan of semi-permanent tattoos, or the residence time of semi-permanent colorants in the skin, may be limited by the natural skin exfoliation process and the thickness of each layer of the skin (the thickness of the epidermis may depend on the body region).

[0082] In some embodiments, an ink composition, such as a genipin-based ink composition, as well as a layered adhesive article and the method of applying the semi-permanent tattoo described herein, can provide a single-step semi-permanent tattoo application process. This can promote user adoption by facilitating the easy generation of semi-permanently usable tattoos and can promote improved transfer and color development of semi-permanent tattoos. Furthermore, by using inkjet printing technology to manufacture the product, it is possible to rapidly and economically manufacture customized semi-permanent tattoo products to order and extend the shelf life.

[0083] References to the term "about" have their ordinary meaning in the context of a composition to allow for reasonable variation in amounts that can achieve the same effect and also refer herein to values that are plus or minus 10% of the provided value. For example, "about 20" means or includes amounts from 18 to 22 and including 22.

[0084] As used herein, "colorant" refers to a substance that changes the color of reflected or transmitted light as a result of wavelength-selective absorption.

[0085] As used herein, "semi-permanent colorant" refers to a colorant that penetrates into one or more layers of the skin and cannot be removed from the skin without physical disruption or natural exfoliation of the skin. For example, a semi-permanent colorant can penetrate into the stratum corneum and react with other molecules, such as other colorant molecules present in the stratum corneum and / or other molecules, such that the semi-permanent colorant can be immobilized within the stratum corneum. For example, a semi-permanent colorant can potentially crosslink with collagen found in the stratum corneum. In some embodiments, the semi-permanent colorant can react with other molecules, such as other colorant molecules present in the stratum corneum and / or other molecules, to form molecules that are too large to diffuse out of the stratum corneum. In some embodiments where the semi-permanent colorant penetrates into the stratum corneum, the residence time of the colorant is determined by the natural skin exfoliation process. In some embodiments, the semi-permanent colorant cannot be washed away by, for example, water, soap, and / or isopropanol. In some embodiments, the semi-permanent colorant includes natural or synthetic pigments or dyes. In some embodiments, the semi-permanent colorant can include a colorant precursor, such as a molecule like genipin that exhibits color upon reaction with one or more other molecules.

[0086] As used herein, "temporary colorant" refers to a colorant that, when located on the skin or when penetrating the skin, can diffuse from the skin or can be washed away by, for example, water, soap, and / or isopropanol.

[0087] As used herein, "color" refers to the wavelength of electromagnetic radiation visible to the human eye.

[0088] As used herein, "surfactant" or "surface-active substance" refers to a substance that tends to reduce the surface tension of the liquid in which it is dissolved.

[0089] As used herein, "surface" refers to a part of a layer of material (e.g., backing, adhesive backing, adhesive layer, etc.) that can be substantially parallel to different layers. In some examples, the surface area of the surface of a particular layer described herein may be larger than the surface of the edge of the particular layer. For example, the edge of a particular layer can be substantially perpendicular to the surface of the particular layer. As used herein, the term "substantially" is intended to mean that the property need not be absolute but is close enough to achieve the advantage of the property. For example, "substantially parallel" is not limited to absolute parallelism and can include directions that are intended to be parallel but may not be exactly parallel due to manufacturing limitations. For example, a "substantially parallel" feature is closer to the parallel direction than the perpendicular direction and is typically formed within a few degrees of parallel. Similarly, "substantially perpendicular" is not limited to absolute perpendicularity and can include directions that are intended to be perpendicular but may not be exactly perpendicular due to manufacturing limitations. For example, a "substantially perpendicular" feature is closer to the perpendicular direction than the parallel direction and is, for example, within a few degrees of perpendicular.

[0090] Provided herein is an ink composition comprising one or more semi-permanent colorants, one or more volatile solvents, and one or more semi-volatile semi-permanent colorant solubilizers.

[0091] In some embodiments, one or more semi-permanent colorants are present in an amount of about 0.1% to about 20% w / w of the composition. For example, about 0.1% to about 18%, about 0.1% to about 16%, about 0.1% to about 14%, about 0.1% to about 12%, about 0.1% to about 10%, about 0.1% to about 8%, about 0.1% to about 6%, about 0.1% to about 4%, about 0.1% to about 2%, about 16% to about 18%, about 14% to about 18%, about 12% to about 18%, about 10% to about 18%, about 8% to about 18%, about 6% to about 18%, about 4% to about 18%, or about 2% to about 18% w / w. In some embodiments, one or more semi-permanent colorants are present in an amount of about 5% to about 15%, about 5% to about 10%, about 7% to about 11%, about 5% to about 7%, about 6% to about 8%, about 7% to about 9%, about 8% to about 10%, or about 6.5% to about 7.5% w / w of the composition. In some embodiments, one or more semi-permanent colorants are present in an amount of about 1%, about 2%, about 3%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, about 10.5%, about 11%, about 11.5%, about 12%, about 12.5%, about 13%, about 13.5%, about 14%, about 15%, about 16%, about 17%, about 18%, about 19%, or about 20% w / w of the composition.

[0092] In some embodiments, one or more semi-permanent colorants include a colorant precursor. In some embodiments, the colorant precursor is genipin. Thus, in some embodiments, the semi-permanent colorant is genipin. As used herein, "genipin" refers to genipin extract, partially purified genipin extract, and / or purified genipin, as further described herein. Genipin is derived from iridoid glycosides called geniposides that are present in nearly 40 plant species. Further, genipin is a precursor of gardenia blue that undergoes free radical polymerization and / or oligomerization reactions upon exposure to amine groups to form a blue colorant (see, for example, Touyama et al., Chem. Pharm. Bull. 42:668-673, 1994 and Touyama et al., Chem. Pharm. Bull. 42(8):1571-1578, 1994, both of which are incorporated herein by reference in their entirety). When in contact with the skin, genipin can react with amines in the skin to generate a polymer-based and / or oligomer-based blue color in situ. Since the polymer-based and / or oligomer-based blue colorant is too large to penetrate the skin at the relevant concentrations, the penetration profile of genipin may determine the color density profile of the stratum corneum. For example, the average molecular weight of the polymer-based and / or oligomer-based blue colorant has been reported to be 8900±600 daltons, and the polymer-based and / or oligomer-based blue colorant contains 40-44 monomer units (see, for example, Touyama et al., Chem. Pharm. Bull. 42:668-673, 1994). In some embodiments, the average molecular weight of the polymerized and / or oligomerized genipin present in the compositions described herein can range from about 200 daltons to about 15000 daltons. In some embodiments, the average molecular weight of the polymerized and / or oligomerized genipin present in the compositions described herein can range from about 500 daltons to about 15000 daltons. In some embodiments, genipins of multiple different molecular weights can be used.For example, in some embodiments, the compositions described herein can include genipin having an average molecular weight of from about 200 Daltons to about 15,000 Daltons. In some embodiments, the compositions described herein can include genipin having an average molecular weight of from about 200 to about 1000 Daltons, from about 500 to about 1500 Daltons, from about 1000 to about 2000 Daltons, from about 1500 to about 2500 Daltons, from about 2000 to about 3500 Daltons, from 3500 to about 5000 Daltons, from 5000 to about 6500 Daltons, from 6000 to about 8300 Daltons, from about 8300 to about 9500 Daltons, and combinations thereof.

[0093] In some embodiments of the ink compositions described herein, genipin is present in an amount of from about 0.1% to about 20% w / w of the composition. For example, from about 0.1% to about 18%, from about 0.1% to about 16%, from about 0.1% to about 14%, from about 0.1% to about 12%, from about 0.1% to about 10%, from about 0.1% to about 8%, from about 0.1% to about 6%, from about 0.1% to about 4%, from about 0.1% to about 2%, from about 16% to about 18%, from about 14% to about 18%, from about 12% to about 18%, from about 10% to about 18%, from about 8% to about 18%, from about 6% to about 18%, from about 4% to about 18%, or from about 2% to about 18% w / w. In some embodiments, genipin is present in an amount of from about 5% to about 15%, from about 5% to about 10%, from about 7% to about 11%, from about 5% to about 7%, from about 6% to about 8%, from about 7% to about 9%, from about 8% to about 10%, or from about 6.5% to about 7.5% w / w. In some embodiments, genipin is present in an amount of about 1%, about 2%, about 3%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, about 10.5%, about 11%, about 11.5%, about 12%, about 12.5%, about 13%, about 13.5%, about 14%, about 15%, about 16%, about 17%, about 18%, about 19%, or about 20% w / w of the composition.

[0094] In some embodiments, genipin is purified genipin. The presence of amines, such as amines that are endogenous to the plant extract or introduced exogenously, in the genipin solution can pose challenges to shelf-life stability. For example, over time, the reactive precursor can develop into a polymer-based and / or oligomer-based blue semi-permanent colorant prior to application to the skin, which can limit the penetration of the semi-permanent colorant into the stratum corneum. The penetration of genipin into the deeper layers of the stratum corneum can enable the subsequent coloring and retention of the polymer-based and / or oligomer-based blue semi-permanent colorant in the skin, which can lead to an increase in the lifespan of the semi-permanent tattoo. Subsequently, the lifespan of the semi-permanent tattoo, or the residence time of the semi-permanent colorant in the skin, can be limited by the natural skin exfoliation process. In some embodiments, the purified genipin has a purity greater than about 85% w / w. For example, the purified genipin has a purity greater than about 86%, about 88%, about 90%, about 92%, about 94%, about 96%, about 98%, about 99%, or about 99.5% w / w.

[0095] In some embodiments of the ink compositions described herein, purified genipin is present in an amount of about 0.1% to about 20% w / w of the composition. For example, about 0.1% to about 18%, about 0.1% to about 16%, about 0.1% to about 14%, about 0.1% to about 12%, about 0.1% to about 10%, about 0.1% to about 8%, about 0.1% to about 6%, about 0.1% to about 4%, about 0.1% to about 2%, about 16% to about 18%, about 14% to about 18%, about 12% to about 18%, about 10% to about 18%, about 8% to about 18%, about 6% to about 18%, about 4% to about 18%, about 2% to about 18%, 5% to about 15%, or about 5% to about 10% w / w. In some embodiments, purified genipin is present in an amount of about 5% to about 15%, about 5% to about 10%, about 7% to about 11%, about 5% to about 7%, about 6% to about 8%, about 7% to about 9%, about 8% to about 10%, or about 6.5% to about 7.5% w / w of the composition. In some embodiments of the ink compositions described herein, purified genipin is about 1%, about 2%, about 3%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, about 10.5%, about 11%, about 11.5%, about 12%, about 12.5%, about 13%, about 13.5%, about 14%, about 15%, about 16%, about 17%, about 18%, about 19%, or about 20% w / w of the composition.

[0096] Volatile solvents can include liquids that vaporize at room temperature. Non-limiting examples of volatile solvents include water, methanol, ethanol, and isopropanol. In some embodiments, the solvent can be selected to have a low toxicity profile when used as described herein. For example, the solvent can be selected such that the residual solvent remaining after the ink has dried on the applicator does not reach a toxic amount for contact with the human skin surface.

[0097] In some embodiments of the ink compositions described herein, one or more volatile solvents are present in an amount of from about 0.1% to about 95% w / w of the composition. For example, from about 10% to about 95%, from about 20% to about 95%, from about 30% to about 95%, from about 40% to about 95%, from about 50% to about 95%, from about 60% to about 95%, from about 70% to about 95%, from about 80% to about 95%, from about 10% to about 20%, from about 10% to about 30%, from about 10% to about 40%, from about 10% to about 50%, from about 10% to about 60%, from about 10% to about 70%, from about 10% to about 80%, or from about 10% to about 90% w / w. In some embodiments of the ink compositions described herein, one or more volatile solvents are present in an amount of from about 55% to about 75%, from about 60% to about 80%, from about 65% to about 85%, from about 70% to about 90%, from about 75% to about 95%, from about 50% to about 75%, from about 55% to about 80%, from about 60% to about 85%, from about 65% to about 90%, from about 60% to about 70%, from about 65% to about 75%, from about 70% to about 80%, or from about 75% to about 85% w / w. For example, from about 60% to about 65%, from about 62% to about 67%, from about 65% to about 70%, from about 67% to about 72%, from about 70% to about 75%, from about 72% to about 77%, from about 75% to about 80%, from about 77% to about 82%, from about 80% to about 85%, from about 82% to about 87%, from about 85% to about 90%, from about 87% to about 92% or from about 90% to about 95% w / w. In some embodiments of the ink compositions described herein, one or more volatile solvents are present in an amount of about 50%, about 55%, about 60%, about 65%, about 66%, about 67%, about 68%, about 69%, about 70%, about 71%, about 72%, about 73%, about 74%, about 75%, about 76%, about 77%, about 78%, about 79%, about 80%, about 85%, about 90%, or about 95% w / w of the composition.

[0098] In some embodiments, the one or more volatile solvents can be solvents in which a semi-permanent colorant, such as a colorant precursor like genipin, is soluble. For example, in some embodiments of the ink compositions described herein, the one or more volatile solvents are solvents in which a semi-permanent colorant, such as a colorant precursor like genipin, has a solubility of at least 5% w / w of the composition, such as at least 6%, at least 7%, at least 8%, or at least 9% w / w of the composition. In some embodiments of the ink compositions described herein, a semi-permanent colorant, such as a colorant precursor like genipin, has a solubility of about 9% w / w of the composition. In some embodiments, the one or more volatile solvents are selected from the group consisting of water, methanol, ethanol, and isopropanol.

[0099] In some embodiments of the ink compositions described herein, combinations of volatile solvents can be used. In some embodiments, each volatile solvent can independently be present in an amount of about 5% to about 80%. For example, about 5% to about 10%, about 5% to about 20%, about 5% to about 30%, about 5% to about 40%, about 5% to about 50%, about 5% to about 60%, about 5% to about 70%, about 70% to about 80%, about 60% to about 80%, about 50% to about 80%, about 40% to about 80%, about 30% to about 80%, about 20% to about 80%, or about 10% to about 80% w / w of the composition. In some embodiments, the volatile solvents independently are present in an amount of about 20% to about 30%, about 25% to about 35%, about 30% to about 40%, about 35% to about 45%, about 40% to about 50%, or about 45% to about 50% w / w of the composition. For example, about 20%, about 25%, about 26%, about 27%, about 28%, about 29%, about 30%, about 31%, about 32%, about 33%, about 34%, about 35%, about 36%, about 37%, about 38%, about 39%, about 40%, about 41%, about 42%, about 43%, about 44%, about 45%, about 46%, about 47%, about 48%, about 49%, or about 50% w / w of the composition.

[0100] In some embodiments of the ink composition described herein, one or more volatile solvents can include a combination of water and ethanol. In some embodiments, water can be present independently in an amount of about 40% to about 55% w / w of the composition, and ethanol can be present independently in an amount of about 15% to about 30% w / w of the composition. In some embodiments, water can be present independently in an amount of about 45% to about 50% w / w of the composition, and independently, ethanol can be present in an amount of about 20% to about 27% w / w of the composition. In some embodiments, water can be present independently in an amount of about 25% to about 40% w / w of the composition, and ethanol can be present independently in an amount of about 35% to about 50% w / w of the composition. In some embodiments, water can be present independently in an amount of about 25% to about 35% w / w of the composition, and ethanol can be present independently in an amount of about 35% to about 45% w / w of the composition. In some embodiments, water can be present independently in an amount of about 28% to about 32% w / w of the composition, and ethanol can be present independently in an amount of about 40% to about 45% w / w of the composition.

[0101] As used herein, the "semi-volatile semi-permanent colorant solubilizer" refers to a semi-volatile solvent in which a semi-permanent colorant, such as a colorant precursor like genipin, is soluble. In some embodiments of the compositions described herein, a semi-permanent colorant, such as a colorant precursor like genipin, exhibits a solubility greater than 5 mg / mL in one or more semi-volatile semi-permanent colorant solubilizers. In some embodiments of the compositions described herein, genipin exhibits a solubility greater than 5 mg / mL in one or more semi-volatile semi-permanent colorant solubilizers. Delivery of the semi-permanent colorant to the upper skin layer by passive diffusion is driven by the solubility and skin permeability of the semi-permanent colorant in the delivery vehicle. Thus, a solvent that increases the solubility of the semi-permanent colorant in water can help increase the penetration of the semi-permanent colorant into the stratum corneum. Non-limiting examples of semi-volatile semi-permanent colorant solubilizers include polyethylene glycol, alkyl glycol, and alkylene glycol ether. Alkylene glycol ethers may include ethylene glycol dimethyl ether, ethylene glycol diethyl ether, and ethylene glycol dibutyl ether.

[0102] In some embodiments of the ink compositions described herein, one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of from about 0.1% to about 95% w / w of the composition. For example, from about 1% to about 95%, from about 5% to about 95%, from about 10% to about 95%, from about 20% to about 95%, from about 30% to about 95%, from about 40% to about 95%, from about 50% to about 95%, from about 60% to about 95%, from about 70% to about 95%, from about 80% to about 95%, from about 10% to about 20%, from about 10% to about 30%, from about 10% to about 40%, from about 10% to about 50%, from about 10% to about 60%, from about 10% to about 70%, from about 10% to about 80%, or from about 10% to about 90% w / w of the composition. In some embodiments of the ink compositions described herein, one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of from about 1% to about 30%, from about 5% to about 35%, from about 10% to about 40%, from about 1% to about 20%, from about 5% to about 20%, from about 10% to about 25%, from about 15% to about 30%, from about 30% to about 35%, from about 25% to about 40%, from about 1% to about 10%, from about 5% to about 15%, from about 10% to about 20%, or from about 15% to about 25% w / w of the composition. For example, from about 10% to about 15%, from about 12% to about 17%, from about 15% to about 20%, from about 17% to about 22%, from about 20% to about 25%, from about 22% to about 27%, from about 25% to about 30%, from about 27% to about 32%, from about 30% to about 35%, from about 32% to about 37%, or from about 35% to about 40% w / w of the composition. In some embodiments of the ink compositions described herein, one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 5%, about 6%, about 7%, about 8%, about 9%, about 10%, about 11%, about 12%, about 13%, about 14%, about 15%, about 16%, about 17%, about 18%, about 19%, about 20%, about 21%, about 22%, about 23%, about 24%, about 25%, about 26%, about 27%, about 28%, about 29%, or about 30% w / w of the composition.

[0103] In some embodiments of the ink compositions described herein, one or more semi-volatile semi-permanent colorant solubilizers are selected from the group consisting of polyethylene glycol, alkyl glycol, alkylene glycol ether, and combinations of two or more thereof.

[0104] In some embodiments of the ink compositions described herein, one or more semi-volatile semi-permanent colorant solubilizers are alkyl glycols. In some embodiments, the alkyl glycol is diethylene glycol monoethyl ether (e.g., ethoxydiglycol, TRANSCUTOL® CG). In some embodiments, diethylene glycol monoethyl ether is present in an amount of about 1% to about 30%, about 5% to about 35%, about 10% to about 40%, about 1% to about 20%, about 5% to about 20%, about 10% to about 25%, about 15% to about 30%, about 30% to about 35%, about 25% to about 40%, about 1% to about 10%, about 5% to about 15%, about 10% to about 20%, or about 15% to about 25% w / w of the composition. For example, about 10% to about 15%, about 12% to about 17%, about 15% to about 20%, about 17% to about 22%, about 20% to about 25%, about 22% to about 27%, about 25% to about 30%, about 27% to about 32%, about 30% to about 35%, about 32% to about 37%, or about 35% to about 40% w / w of the composition. In some embodiments, diethylene glycol monoethyl ether is present in an amount of about 5%, about 6%, about 7%, about 8%, about 9%, about 10%, about 11%, about 12%, about 13%, about 14%, about 15%, about 16%, about 17%, about 18%, about 19%, about 20%, about 21%, about 22%, about 23%, about 24%, about 25%, about 26%, about 27%, about 28%, about 29%, or about 30% w / w of the composition.

[0105] In some embodiments of the ink compositions described herein, one or more semi-volatile semi-permanent colorant solubilizers are diethylene glycol monoethyl ether.

[0106] In some embodiments of the ink compositions described herein, the composition has a viscosity of from about 1 to about 20 centipoise. For example, from about 1 to about 19, from about 1 to about 18, from about 1 to about 17, from about 1 to about 16, from about 1 to about 15, from about 1 to about 14, from about 1 to about 13, from about 1 to about 12, from about 1 to about 11, from about 1 to about 10, from about 1 to about 9, from about 1 to about 8, from about 1 to about 7, from about 1 to about 6, from about 1 to about 5, from about 1 to about 4, from about 1 to about 3, from about 1 to about 2, from about 19 to about 20, from about 18 to about 20, from about 17 to about 20, from about 16 to about 20, from about 15 to about 20, from about 14 to about 20, from about 13 to about 20, from about 12 to about 20, from about 11 to about 20, from about 10 to about 20, from about 9 to about 20, from about 8 to about 20, from about 7 to about 20, from about 6 to about 20, from about 5 to about 20, from about 4 to about 20, from about 3 to about 20 centipoise, or from about 2 to about 20 centipoise. In some embodiments, the composition has a viscosity of from about 5 to about 15, from about 5 to about 10, from about 10 to about 15, from about 2 to about 4, from about 3 to about 5, or from about 4 to about 6 centipoise. In some embodiments of the ink compositions described herein, the composition has a viscosity of about 3, about 3.25, about 3.5, about 3.75, about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, about 7, about 8, about 9, about 10, about 11, about 12, about 13, about 14, about 15, about 16, about 17, about 18, about 19, or about 20 centipoise.

[0107] In some embodiments of the ink compositions described herein, the composition is configured to have a viscosity of from about 1 to about 7 centipoise. For example, from about 1 to about 6, from about 1 to about 5, from about 1 to about 4, from about 1 to about 3, from about 1 to about 2, from about 6 to about 7, from about 5 to about 7, from about 4 to about 7, from about 3 to about 7 centipoise, or from about 2 to about 7 centipoise. In some embodiments, the composition is configured to have a viscosity of from about 2 to about 4, from about 3 to about 5, or from about 4 to about 6 centipoise. In some embodiments of the ink compositions described herein, the composition is configured to have a viscosity of about 3, about 3.25, about 3.5, about 3.75, about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, about 7, about 8, about 9, about 10, about 11, about 12, about 13, about 14, about 15, about 16, about 17, about 18, about 19, or about 20 centipoise.

[0108] In some embodiments of the ink compositions described herein, the composition has a surface tension of from about 10 to about 45 dynes / cm. For example, from about 10 to about 20, from about 10 to about 30, from about 10 to about 45, from about 40 to about 45, from about 30 to about 45, or from about 20 to about 45 dynes / cm. In some embodiments of the ink compositions described herein, the composition has a surface tension of from about 15 to about 25, from about 20 to about 30, from about 25 to about 35, from about 30 to about 40, from about 35 to about 45 or from about 20 to about 35 dynes / cm. For example, about 20, about 21, about 22, about 23, about 24, about 25, about 26, about 27, about 28, about 29, about 30, about 31, about 32, about 33, about 34, or about 35 dynes / cm.

[0109] In some embodiments of the ink compositions described herein, the composition is configured to have a surface tension of from about 10 to about 45 dynes / cm. For example, from about 10 to about 20, from about 10 to about 30, from about 10 to about 45, from about 40 to about 45, from about 30 to about 45, or from about 20 to about 45 dynes / cm. In some embodiments of the ink compositions described herein, the composition is configured to have a surface tension of from about 15 to about 25, from about 20 to about 30, from about 25 to about 35, from about 30 to about 40, from about 35 to about 45 or from about 20 to about 35 dynes / cm. For example, about 20, about 21, about 22, about 23, about 24, about 25, about 26, about 27, about 28, about 29, about 30, about 31, about 32, about 33, about 34, or about 35 dynes / cm.

[0110] In some embodiments of the ink compositions described herein, the composition further comprises one or more surfactants. Non-limiting examples of surfactants include alkylbenzene sulfonate, alkyl sulfate, alkyl ether sulfate, soap, ethoxylate, alkyl alcohol, lignosulfonate, and triglyceride. For example, surfactants may include sodium dodecylbenzene sulfonate, lauryl sulfate, dialkyl sulfosuccinate, dimethyl ether of tetradecylphosphonic acid, lauryl monoethanol, glycerol diester (diglyceride), dodecyl betaine, abietic acid, polyethoxylated octylphenol, 1,2 - hexanediol (e.g., OPTIPHEN® HD), and sorbitan monoester.

[0111] In some embodiments of the ink compositions described herein, the composition further comprises one or more surfactants. In some embodiments, the one or more surfactants are present in an amount of about 0.1% to about 10% w / w of the composition. For example, about 0.1% to about 8%, about 0.1% to about 6%, about 0.1% to about 5%, about 0.1% to about 4%, about 0.1% to about 3%, about 0.1% to about 2%, about 0.1% to about 1%, about 8% to about 10%, about 6% to about 10%, about 4% to about 10%, about 3% to about 10%, about 2% to about 10%, or about 1% to about 10% w / w. In some embodiments of the ink compositions described herein, the one or more surfactants are present in an amount of about 0.25% to about 5% w / w of the composition. For example, about 0.25% to about 5%, about 0.25% to about 4%, about 0.25% to about 3%, about 0.25% to about 2%, about 0.25% to about 1%, about 2% to about 5%, about 2% to about 4%, about 2% to about 3%, about 1% to about 4%, about 1% to about 3%, about 1% to about 2%, about 3% to about 5%, about 4% to about 5%, about 3% to about 5%, about 2% to about 5%, or about 1% to about 5% w / w. In some embodiments, the one or more surfactants are present in an amount of about 0.25%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 7%, about 8%, about 9%, or about 10% w / w of the composition.

[0112] In some embodiments of the ink compositions described herein, the one or more surfactants are selected from the group consisting of alkylbenzene sulfonates, polyethylene glycols, alkyl sulfates, alkyl ether sulfates, soaps, ethoxylates, lignosulfonates, and triglycerides. In some embodiments, the one or more surfactants are selected from the group consisting of sodium dodecylbenzene sulfonate, lauryl sulfate, dialkyl sulfosuccinate, dimethyl ether of tetradecylphosphonic acid, lauryl monoethanol, glycerol diester (diglyceride), dodecyl betaine, abietic acid, polyethoxylated octylphenol, 1,2 - hexanediol, and sorbitan monoester.

[0113] In some embodiments of the ink compositions described herein, one or more surfactants are 1,2 - hexanediol. In some embodiments, 1,2 - hexanediol is present in an amount of about 0.1% to about 10% w / w of the composition. For example, about 0.1% to about 8%, about 0.1% to about 6%, about 0.1% to about 5%, about 0.1% to about 4%, about 0.1% to about 3%, about 0.1% to about 2%, about 0.1% to about 1%, about 8% to about 10%, about 6% to about 10%, about 4% to about 10%, about 3% to about 10%, about 2% to about 10%, or about 1% to about 10% w / w. In some embodiments of the ink compositions described herein, 1,2 - hexanediol is present in an amount of about 0.25% to about 5% w / w of the composition. For example, about 0.25% to about 5%, about 0.25% to about 4%, about 0.25% to about 3%, about 0.25% to about 2%, about 0.25% to about 1%, about 2% to about 5%, about 2% to about 4%, about 2% to about 3%, about 1% to about 4%, about 1% to about 3%, about 1% to about 2%, about 3% to about 5%, about 4% to about 5%, about 3% to about 5%, about 2% to about 5%, or about 1% to about 5% w / w. In some embodiments, 1,2 - hexanediol is present in an amount of about 0.25%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 7%, about 8%, about 9%, or about 10% w / w of the composition.

[0114] In some embodiments of the ink compositions described herein, one or more surfactants are polyethylene glycol 400 (PEG400). In some embodiments, PEG400 is present in an amount of about 0.1% to about 10% w / w of the composition. For example, about 0.1% to about 8%, about 0.1% to about 6%, about 0.1% to about 5%, about 0.1% to about 4%, about 0.1% to about 3%, about 0.1% to about 2%, about 0.1% to about 1%, about 8% to about 10%, about 6% to about 10%, about 4% to about 10%, about 3% to about 10%, about 2% to about 10%, or about 1% to about 10% w / w. In some embodiments of the ink compositions described herein, PEG400 is present in an amount of about 0.25% to about 5% w / w of the composition. For example, about 0.25% to about 5%, about 0.25% to about 4%, about 0.25% to about 3%, about 0.25% to about 2%, about 0.25% to about 1%, about 2% to about 5%, about 2% to about 4%, about 2% to about 3%, about 1% to about 4%, about 1% to about 3%, about 1% to about 2%, about 3% to about 5%, about 4% to about 5%, about 3% to about 5%, about 2% to about 5%, or about 1% to about 5% w / w. In some embodiments of the ink compositions described herein, PEG400 is present in an amount of about 0.25%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 7%, about 8%, about 9%, or about 10% w / w of the composition.

[0115] In some embodiments of the ink compositions described herein, the composition further comprises one or more matrix components. The matrix component can form a solid or semi-solid immobilized matrix on the substrate. For example, after the ink composition described herein is applied to the substrate and the ink dries, e.g., after the volatile solvent has evaporated or substantially evaporated from the substrate, the matrix component can form a solid or semi-solid immobilized matrix on the substrate. Non-limiting examples of matrix components include sugars, sugar alcohols (e.g., sorbitol, mannitol, xylitol, isomalt, hydrolyzed hydrogenated starch), polymers, or combinations of two or more thereof. For example, sugars can include monosaccharides (e.g., glucose, fructose, galactose, ribose, and xylose), disaccharides (e.g., trehalose such as trehalose 100, sucrose, lactotrehalose, galactotrehalose, 6-azidotrehalose, maltose, lactose, lactulose, cellobiose, and chitobiose), or oligosaccharides (e.g., starch, glycogen, cellulose, and chitin). In some embodiments, polymers can include pullulan, cellulose derivatives (e.g., hydroxypropylmethylcellulose, hydroxyethylcellulose, and hydroxymethylcellulose), acrylates, polyvinyl alcohol, ethylene oxide / propylene oxide copolymers, and polyesters.

[0116] In some embodiments of the ink compositions described herein, one or more matrix components are present in an amount of from about 0.1% to about 50% w / w of the composition. For example, from about 0.1% to about 25%, from about 25% to about 50%, or from about 15% to about 35% w / w of the composition. In some embodiments of the ink compositions described herein, one or more matrix components are present in an amount of from about 0.1% to about 10% w / w of the composition. For example, from about 0.1% to about 8%, from about 0.1% to about 6%, from about 0.1% to about 4%, from about 0.1% to about 3%, from about 0.1% to about 2%, from about 0.1% to about 1%, from about 8% to about 10%, from about 6% to about 10%, from about 4% to about 10%, from about 2% to about 10%, from about 1% to about 5%, from about 1% to about 4%, from about 1% to about 3%, from about 1% to about 2%, from about 2% to about 5%, from about 2% to about 4%, from about 2% to about 3%, or from about 3% to about 5% w / w. In some embodiments of the ink compositions described herein, one or more matrix components are present in an amount of about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 7%, about 8%, about 9%, or about 10% w / w of the composition.

[0117] In some embodiments of the ink compositions described herein, one or more matrix components are selected from the group consisting of sugars, sugar alcohols, polymers, or combinations of two or more thereof. In some embodiments, one or more matrix components are selected from the group consisting of sorbitol, mannitol, xylitol, isomalt, hydrolyzed hydrogenated starch, glucose, fructose, galactose, ribose, xylose, trehalose, sucrose, lactotrehalose, galactotrehalose, 6-azidotrehalose, maltose, lactose, lactulose, cellobiose, chitobiose, starch, glycogen, cellulose, chitin, pullulan, hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, acrylate, polyvinyl alcohol, ethylene oxide / propylene oxide copolymer, and polyester.

[0118] In some embodiments of the ink compositions described herein, one or more matrix components are trehalose. In some embodiments, trehalose is present in the composition in an amount of about 0.1% to about 8%, about 0.1% to about 6%, about 0.1% to about 4%, about 0.1% to about 3%, about 0.1% to about 2%, about 0.1% to about 1%, about 8% to about 10%, about 6% to about 10%, about 4% to about 10%, about 2% to about 10%, about 1% to about 5%, about 1% to about 4%, about 1% to about 3%, about 1% to about 2%, about 2% to about 5%, about 2% to about 4%, about 2% to about 3%, or about 3% to about 5% w / w. In some embodiments, trehalose is present in the composition in an amount of about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 7%, about 8%, about 9%, or about 10% w / w.

[0119] In some embodiments of the ink compositions described herein, one or more matrix components are hydroxypropyl methylcellulose. In some embodiments, hydroxypropyl methylcellulose is present in the composition in an amount of about 0.1% to about 8%, about 0.1% to about 6%, about 0.1% to about 4%, about 0.1% to about 3%, about 0.1% to about 2%, about 0.1% to about 1%, about 8% to about 10%, about 6% to about 10%, about 4% to about 10%, about 2% to about 10%, about 1% to about 5%, about 1% to about 4%, about 1% to about 3%, about 1% to about 2%, about 2% to about 5%, about 2% to about 4%, or about 3% to about 5% w / w. In some embodiments, hydroxypropyl methylcellulose is present in the composition in an amount of about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 7%, about 8%, about 9%, or about 10% w / w.

[0120] In some embodiments of the ink compositions described herein, the composition further comprises one or more skin penetration enhancers. As used herein, "skin penetration enhancer" refers to a substance that penetrates the skin (is penetrative) and reversibly reduces the barrier resistance. In some embodiments of the ink compositions described herein, the skin penetration enhancer can also increase the solubility of the penetrant and increase the loading, which can, for example, increase the flux of the penetrant across the skin. Non-limiting examples of skin penetration enhancers include alcohols, amides, esters, ether alcohols, fatty acids, glycols, pyrrolidones, sulfoxides, surfactants, and terpenes. For example, skin penetration enhancers include ethanol, isopropanol, decanol, hexanol, lauryl alcohol, myristyl alcohol, octanol, octyldodecanol, oleyl alcohol, azone, ethyl acetate, octyl salicylate, padimate O, ethyl oleate, glyceryl monooleate, glyceryl monocaprylate, glyceryl tricaprylate, isopropyl myristate, isopropyl palmitate, propylene glycol monolaurate, propylene glycol monocaprylate, diethylene glycol monoethyl ether (TRANSCUTOL®), lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, stearic acid, isostearic acid, dipropylene glycol, propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, n-methyl-2-pyrrolidone, 2-pyrrolidone, decyl methyl sulfoxide, dimethyl sulfoxide, sodium lauryl sulfate, alkyl dimethyl benzyl ammonium halide, alkyl trimethyl ammonium halide, alkyl pyridinium halide, brij 36t, polyethylene glycol sorbitan monooleate (e.g., TWEEN® 80), eugenol, D-limonene, menthol, menthone, farnesol, and neridol. See, for example, Lane, Int. J. Pharm. 447:12-21, 2013, which is incorporated herein by reference in its entirety.

[0121] In some embodiments of the ink compositions described herein, one or more skin penetration enhancers are present in an amount of about 0.1% to about 50% w / w of the composition. For example, about 0.1% to about 25%, about 25% to about 50%, or about 15% to about 35% w / w of the composition. In some embodiments, one or more skin penetration enhancers are present in an amount of about 0.1% to about 10% w / w of the composition. In some embodiments of the ink compositions described herein, the surfactant is present in an amount of about 0.5% to about 5% w / w of the composition. For example, about 0.5% to about 5%, about 0.5% to about 4%, about 0.5% to about 3%, about 0.5% to about 2%, about 2% to about 5%, about 2% to about 4%, or about 3% to about 5% w / w of the composition. In some embodiments of the ink compositions described herein, one or more skin penetration enhancers are present in an amount of about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 7%, about 8%, about 9%, or about 10% w / w of the composition.

[0122] In some embodiments of the ink composition described herein, the one or more skin penetration enhancers are selected from the group consisting of alcohols, amides, esters, ether alcohols, fatty acids, glycols, pyrrolidones, sulfoxides, surfactants, and terpenes. In some embodiments, the one or more skin penetration enhancers are ethanol, isopropanol, decanol, hexanol, lauryl alcohol, myristyl alcohol, octanol, octyldodecanol, oleyl alcohol, azone, ethyl acetate, octyl salicylate, padimate O, ethyl oleate, glyceryl monooleate, glyceryl monocaprylate, glyceryl tricaprylate, isopropyl myristate, isopropyl palmitate, propylene glycol monolaurate, propylene glycol monocaprylate, diethylene glycol monoethyl ether (TRANSCUTOL®), lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, stearic acid, isostearic acid, dipropylene glycol, propylene glycol, 1,2 - butylene glycol, 1,3 - butylene glycol, n - methyl - 2 - pyrrolidone, 2 - pyrrolidone, decyl methyl sulfoxide, dimethyl sulfoxide, sodium lauryl sulfate, alkyldimethylbenzylammonium halide, alkyltrimethylammonium halide, alkylpyridinium halide, brij 36t, polyethylene glycol sorbitan monooleate (e.g., TWEEN® 80), eugenol, D - limonene, menthol, menthone, farnesol, and neridol.

[0123] In some embodiments of the ink compositions described herein, the one or more skin penetration enhancers are selected from the group consisting of alcohols, amides, esters, ether alcohols, fatty acids, glycols, pyrrolidones, sulfoxides, surfactants, and terpenes. In some embodiments, the one or more skin penetration enhancers are ethanol, isopropanol, decanol, hexanol, lauryl alcohol, myristyl alcohol, octanol, octyldodecanol, oleyl alcohol, azone, ethyl acetate, octyl salicylate, padimate O, ethyl oleate, glyceryl monooleate, glyceryl monocaprylate, glyceryl tricaprylate, isopropyl myristate, isopropyl palmitate, propylene glycol monolaurate, propylene glycol monocaprylate, lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, stearic acid, isostearic acid, dipropylene glycol, propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, n-methyl-2-pyrrolidone, 2-pyrrolidone, decyl methyl sulfoxide, dimethyl sulfoxide, sodium lauryl sulfate, alkyldimethylbenzylammonium halide, alkyltrimethylammonium halide, alkylpyridinium halide, brij 36t, polyethylene glycol sorbitan monooleate (e.g., TWEEN® 80), eugenol, D-limonene, menthol, menthone, farnesol, and neridol.

[0124] In some embodiments of the ink compositions described herein, the composition further comprises one or more temporary colorants. In some embodiments of the ink compositions described herein, the temporary colorant can be used to show how the semi-permanent tattoo will look, outline the position of the semi-permanent tattoo on the applicator, and provide a logo, e.g., a brand logo, that does not transfer to the skin or transfers but is present for a short time compared to the duration of the semi-permanent tattoo. In some embodiments of the ink compositions described herein, the temporary colorant can be used to provide a changing semi-permanent tattoo that changes in appearance over time, e.g., with the duration of the semi-permanent colorant and the duration of the temporary colorant.Non-limiting examples of temporary colorants include iron oxide black (Fe3O4), iron oxide (FeO), carbon, logwood, loess, cinnabar (HgS), cadmium red (CdSe), iron(III) oxide (Fe2O3), naphthol-AS pigments, disazo diarylide, disazo pyrazolone, cadmium selenosulfide, cadmium yellow (CdS, CdZnS), curcuma yellow, chrome yellow (PbCrO4), disazo diarylide, chromium oxide (Cr2O3), malachite [Cu2(CO3)(OH)2], ferrocyanide, ferricyanide, lead chromate, monoazo pigments, Cu / Al phthalocyanine, Cu phthalocyanine, azur blue, cobalt blue, Cu-phthalocyanine, manganese violet (ammonium manganese pyrophosphate), aluminum salts, quinacridone, dioxazine / carbazole, lead white (lead carbonate), titanium dioxide (TiO2), barium sulfate (BaSO4), zinc oxide, anthraquinone dyes and derivatives, anatto, caramel, β-carotene, bismuth citrate, EDTA disodium copper, potassium sodium copper chlorophyllin, dihydroxyacetone, bismuth oxy chloride, guaiac azulene, henna, ammonium iron ferrocyanide, iron ferrocyanide, chromium hydroxide green, chromium oxide green, guanine, lead acetate, pyrophyllite, mica, silver, titanium dioxide, aluminum powder, bronze powder, copper powder, ultramarine, manganese violet, zinc oxide, luminescent zinc sulfide, D&C Black No. 2 and 3, FD&C Blue No. 1 (e.g., Acid Blue 9), D&C Blue No. 4, D&C Brown No. 1, FD&C Green No. 3, D&C Green No. 5, 6 and 8, D&C Orange No. 4, 5, 10 and 11, FD&C Red No. 4, D&C Red No. 6, 7, 17, 21, 22, 27, 28, 30, 32, 33, 34, 36, and 40, D&C Violet No. 2, Ext.D&C Violet No. 2, FD&C Yellow No. 5 and 6, D&C Yellow No. 7, 8, 10 and 11, and Ext.D&C Yellow No. 7. In some embodiments, the temporary colorant does not contain an amine group. In some embodiments, the temporary colorant does not contain an amine group.

[0125] In some embodiments of the ink compositions described herein, one or more temporary colorants are present in an amount of from about 0.01% to about 5% w / w of the composition. For example, from about 0.01% to about 5%, from about 0.01% to about 4%, from about 0.01% to about 3%, from about 0.01% to about 2%, from about 0.01% to about 1%, from about 0.01% to about 0.5%, from about 0.5% to about 5%, from about 1% to about 5%, from about 2% to about 5%, from about 3% to about 5% w / w, from about 4% to about 5%, or from about 2% to about 4% w / w. In some embodiments, one or more temporary colorants are present in an amount of from about 0.06% to about 0.1%, from about 0.07% to about 0.11%, from about 0.08% to about 0.12%, from about 0.09% to about 0.13%, from about 0.1% to about 0.14%, from about 0.11% to about 0.15%, from about 0.12% to about 0.16%, from about 0.13% to about 0.17%, from about 0.14% to about 0.18%, from about 0.15% to about 0.19%, from about 0.16% to about 0.2%, from about 0.17% to about 0.21%, or from about 0.18% to about 0.22% w / w. In some embodiments, one or more temporary colorants are present in an amount of about 0.01%, about 0.02%, about 0.03%, about 0.04%, about 0.05%, about 0.06%, about 0.07%, about 0.08%, about 0.09%, about 0.1%, about 0.11%, about 0.12%, about 0.13%, about 0.14%, about 0.15%, about 0.16%, about 0.17%, about 0.18%, about 0.19%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.8%, from about 1% to about 2%, from about 1.5% to about 2.5%, from about 2% to about 3%, from about 2.5% to about 3%, from about 3% to about 4%, from about 3.5% to about 4.5%, or from about 4% to about 5% w / w. In some embodiments of the ink compositions described herein, one or more temporary colorants are present in an amount of from about 0.01% to about 1%, from about 0.01% to about 0.1%, from about 0.01% to about 0.2%, from about 0.01% to about 0.3%, from about 0.01% to about 0.4%, from about 0.01% to about 0.5%, from about 0.01% to about 0.6%, from about 0.01% to about 0.7%, from about 0.01% to about 0.8%, from about 0.01% to about 0.9%, from about 0.9% to about 1%, from about 0.8% to about 1%, from about 0.7% to about 1%, from about 0.6% to about 1%, from about 0.5% to about 1%, from about 0.4% to about 1%, from about 0.3% to about 1%, from about 0.2% to about 1%, from about 0.1% to about 1% w / w.For example, about 0.1% to about 0.3%, about 0.2% to about 0.4%, or about 0.3% to about 0.5% w / w of the composition. In some embodiments of the ink compositions described herein, one or more temporary colorants are present in an amount of about 0.01%, about 0.05%, about 0.1%, about 0.15%, about 0.2%, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 7%, about 8%, about 9%, or about 10% w / w of the composition.

[0126] In some embodiments, one or more temporary colorants are Acid Blue 9 (e.g., FD&C Blue No. 1). In some embodiments, Acid Blue 9 is present in an amount of about 0.01% to about 5% w / w of the composition. For example, about 0.01% to about 5%, about 0.01% to about 4%, about 0.01% to about 3%, about 0.01% to about 2%, about 0.01% to about 1%, about 0.01% to about 0.5%, about 2% to about 5%, about 3% to about 5% w / w, about 4% to about 5%, or about 2% to about 4%. In some embodiments, Acid Blue 9 is present in an amount of about 0.01%, about 0.02%, about 0.03%, about 0.04%, about 0.05%, about 0.06%, about 0.07%, about 0.08%, about 0.09%, about 0.1%, about 0.11%, about 0.12%, about 0.13%, about 0.14%, about 0.15%, about 0.16%, about 0.17%, about 0.18%, about 0.19%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.8%, about 1% to about 2%, about 1.5% to about 2.5%, about 2% to about 3%, about 2.5% to about 3%, about 3% to about 4%, about 3.5% to about 4.5%, or about 4% to about 5% w / w of the composition. In some embodiments of the ink compositions described herein, Acid Blue 9 is present in an amount of about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 7%, about 8%, about 9%, or about 10% w / w of the composition.

[0127] In some embodiments, the ink composition further comprises one or more preservatives. As used herein, "preservative" refers to an agent that protects against disintegration, discoloration, and / or spoilage. Non-limiting examples of preservatives include ascorbic acid, ascorbate, palmitate, citric acid, benzoate, benzoic acid, propionate, propionic acid, sorbate, sorbic acid, salicylic acid, salicylate, hex-2,4-dienoic acid, hex-2,4-dienoate, formaldehyde, formaldehyde-releasing agents, formic acid and its salts, 3-acetyl-6-methylpyran-2,4-(3H)-dione and its salts, 3,3'-dibromo-4,4'-hexamethylenedioxydibenzamidine and its salts, thimerosal, phenylmercury salts, undec-10-enoic acid and its salts, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-5-pyrimidine, 5-bromo-5-nitro-1,3-dioxane, bronopol, 2,4-dichlorobenzyl alcohol, 1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea, chlorocresol, chloroxylenol, 5-chloro-2-(2,4-dichlorophenoxy)phenol, N,N”-methylenebis[N’-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea], polyaminopropylbiguanide, methenamine, quaternium-15, climbazole, DMDM hydantoin, benzyl alcohol, 1-hydroxy-4-methyl-6-(2,4,4-(Trimethylpentyl)-2-pyridone, piroctone olamine, bromochlorophene, o-cymen-5-ol, chlorophene, chloroacetamide, methylchloroisothiazolinone, methylisothiazolinone, phenoxyisopropanol, chlorhexidine, chlorhexidine diacetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, dimethyloxazolidine, behentrimonium chloride, cetrimonium bromide, cetrimonium chloride, laurtrimonium bromide, laurtrimonium chloride, steartrimonium bromide, steartrimonium chloride, diazolidinyl urea, hexamidine, hexamidine diisethionate, hexamidine parabens, glutaral, 7-ethylbicyclooxazolidine, chlorphenesin, sodium hydroxymethylglycinate, silver chloride, benzethonium chloride, benzalkonium chloride, benzalkonium bromide, benzalkonium saccharinate, benzyl hemiformal, iodopropynyl butylcarbamate, biphenyl-2-ol and its salts, zinc pyrithione, erythorbate, nitrous acid, ethylenediaminetetraacetic acid (EDTA), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), capric acid, dilauryl thiodipropionate, erythorbic acid, guaiac resin, methylparaben, sulfite, bisulfite, metabisulfite, propyl gallate, propylparaben, stannous chloride, sulfur dioxide, thiodipropionic acid, isothiazolin, parabens, phenoxyethanol, ethylhexylglycerin, glycol, and tocopherol are mentioned.,

[0128] In some embodiments of the ink compositions described herein, one or more preservatives are present in an amount of from about 0.05% to about 5% w / w of the composition. For example, from about 0.05% to about 0.1%, from about 0.05% to about 0.5%, from about 0.05% to about 1%, from about 0.05% to about 2%, from about 0.05% to about 3%, from about 0.05% to about 4%, from about 4% to about 5%, from about 3% to about 5%, from about 2% to about 5%, from about 1% to about 5%, from about 0.5% to about 5%, or from about 0.1% to about 5% w / w. In some embodiments of the ink compositions described herein, one or more preservatives are present in an amount of from 0.1% to about 2%, from 0.5% to about 2.5%, from about 1% to about 3%, from about 1.5% to about 3.5%, from about 2% to about 4%, from about 2.5% to about 4.5% w / w of the composition. In some embodiments of the ink compositions described herein, one or more preservatives are present in an amount of from about 0.5% to about 2% w / w of the composition. In some embodiments of the ink compositions described herein, one or more preservatives are present in an amount of from about 0.5% to about 1.5%, from about 0.5% to about 1.0%, from about 1.5% to about 2%, from about 1% to about 2%, from about 0.5% to about 2%, or from about 0.8% to about 2% w / w of the composition. For example, from about 0.05% to about 0.4%, from about 0.05% to about 0.2%, from about 0.2% to about 0.5%, from about 0.15% to about 0.25%, or from about 0.1% to about 0.3% w / w. In some embodiments of the ink compositions described herein, one or more preservatives are present in an amount of about 0.01%, about 0.05%, about 0.1%, about 0.12%, about 0.14%, about 0.15%, about 0.16%, about 0.18%, about 0.2%, about 0.22, about 0.25%, about 0.26%, about 0.28%, about 0.3%, about 0.32%, about 0.34%, about 0.35%, about 0.36%, about 0.38%, about 0.4%, about 0.45%, about 0.5%, about 0.6%, about 0.65%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w of the composition.

[0129] In some embodiments of the ink composition described herein, one or more preservatives are ascorbic acid, ascorbate, palmitate, citric acid, benzoate, benzoic acid, propionate, propionic acid, sorbate, sorbic acid, salicylic acid, salicylate, hex-2,4-dienoic acid, hex-2,4-dienoate, formaldehyde, formaldehyde releaser, formic acid and its salts, 3-acetyl-6-methylpyran-2,4-(3H)-dione and its salts, 3,3'-dibromo-4,4'-hexamethylenedioxy dibenzamidine and its salts, thimerosal, phenylmercury salts, undec-10-enoic acid and its salts, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-5-pyrimidine, 5-bromo-5-nitro-1,3-dioxane, bronopol, 2,4-dichlorobenzyl alcohol, 1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea, chlorocresol, chloroxylenol, 5-chloro-2-(2,4-dichlorophenoxy)phenol, N,N”-methylenebis[N’-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea], polyaminopropyl biguanide, methenamine, quaternium-15, climbazole, DMDM hydantoin, benzyl alcohol, 1-hydroxy-4-methyl-6-(2,4,Selected from the group consisting of 4-(trimethylpentyl)-2-pyridone, piroctone olamine, bromochlorophene, o-cymen-5-ol, chlorophene, chloroacetamide, methylchloroisothiazolinone, methylisothiazolinone, phenoxyisopropanol, chlorhexidine, chlorhexidine diacetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, dimethyloxazolidine, behentrimonium chloride, cetrimonium bromide, cetrimonium chloride, laurtrimonium bromide, laurtrimonium chloride, steartrimonium bromide, steartrimonium chloride, diazolidinyl urea, hexamidine, hexamidine diisethionate, hexamidine parabens, glutaral, 7-ethylbicyclooxazolidine, chlorphenesin, sodium hydroxymethylglycinate, silver chloride, benzethonium chloride, benzalkonium chloride, benzalkonium bromide, benzalkonium saccharinate, benzyl hemiformal, iodopropynyl butylcarbamate, biphenyl-2-ol and its salts, zinc pyrithione, erythorbate, nitrous acid, ethylenediaminetetraacetic acid (EDTA), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), capric acid, dilauryl thiodipropionate, erythorbic acid, guaiac resin, methylparabens, sulfite, bisulfite, metabisulfite, propyl gallate, propylparabens, stannous chloride, sulfur dioxide, thiodipropionic acid, isothiazoline, parabens, phenoxyethanol, ethylhexylglycerin, glycol, and tocopherol.,

[0130] In some embodiments of the ink compositions described herein, one or more preservatives are phenoxyethanol and ethylhexylglycerin (e.g., Euxyl® PE9010). In some embodiments of the ink compositions described herein, phenoxyethanol and ethylhexylglycerin are present in the composition at a ratio of 9:1 phenoxyethanol:ethylhexylglycerin.

[0131] In some embodiments of the ink compositions described herein, the composition is configured to have a pH of from about 4 to about 7. For example, from about 4 to about 5, from about 4.5 to about 5.5, from about 5 to about 6, from about 5.5 to about 6.5, or from about 6 to about 7. In some embodiments, the composition is configured to have a pH of about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, or about 7. In some embodiments of the ink compositions described herein, the composition is configured to have a pH of from about 4 to about 6. In some embodiments of the ink compositions described herein, the composition is configured to have a pH of about 4.6.

[0132] In some embodiments of the ink compositions described herein, the composition is adjusted to a pH of from about 4 to about 7. For example, from about 4 to about 5, from about 4.5 to about 5.5, from about 5 to about 6, from about 5.5 to about 6.5, or from about 6 to about 7. In some embodiments, the composition is adjusted to a pH of about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, or about 7. In some embodiments of the ink compositions described herein, the composition is adjusted to a pH of from about 4 to about 6. In some embodiments of the ink compositions described herein, the composition is adjusted to a pH of about 4.6.

[0133] In some embodiments of the ink compositions described herein, the composition has a pH of from about 4 to about 7. For example, from about 4 to about 5, from about 4.5 to about 5.5, from about 5 to about 6, from about 5.5 to about 6.5, or from about 6 to about 7. In some embodiments, the composition has a pH of about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, or about 7. In some embodiments of the ink compositions described herein, the composition has a pH of from about 4 to about 6. In some embodiments of the ink compositions described herein, the composition has a pH of about 4.6.

[0134] In some embodiments of the ink compositions described herein, phenoxyethanol and ethylhexylglycerin are present in an amount of about 0.05% to about 5% w / w of the composition. For example, about 0.05% to about 0.1%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.05% to about 2%, about 0.05% to about 3%, about 0.05% to about 4%, about 4% to about 5%, about 3% to about 5%, about 2% to about 5%, about 1% to about 5%, about 0.5% to about 5%, or about 0.1% to about 5% w / w. In some embodiments of the ink compositions described herein, phenoxyethanol and ethylhexylglycerin are present in an amount of 0.1% to about 2%, 0.5% to about 2.5%, about 1% to about 3%, about 1.5% to about 3.5%, about 2% to about 4%, about 2.5% to about 4.5% w / w of the composition. In some embodiments of the ink compositions described herein, phenoxyethanol and ethylhexylglycerin are present in an amount of about 0.5% to about 2% w / w of the composition. In some embodiments of the ink compositions described herein, phenoxyethanol and ethylhexylglycerin are present in an amount of about 0.5% to about 1.5%, about 0.5% to about 1.0%, about 0.05% to about 0.5%, about 0.05% to about 0.1%, about 1.5% to about 2%, about 1% to about 2%, about 0.5% to about 2%, or about 0.8% to about 2%, or about 0.1% to about 0.9% w / w of the composition. For example, about 0.05% to about 0.4%, about 0.05% to about 0.2%, about 0.2% to about 0.5%, about 0.15% to about 0.25%, or about 0.1% to about 0.3% w / w. In some embodiments of the ink compositions described herein, phenoxyethanol and ethylhexylglycerin are present in an amount of about 0.01%, about 0.05%, about 0.1%, about 0.12%, about 0.14%, about 0.15%, about 0.16%, about 0.18%, about 0.2%, about 0.22, about 0.25%, about 0.26%, about 0.28%, about 0.3%, about 0.32%, about 0.34%, about 0.35%, about 0.36%, about 0.38%, about 0.4%, about 0.45%, about 0.5%, about 0.6%, about 0.65%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w of the composition.

[0135] In some embodiments, the ink composition comprises genipin present in an amount of about 5% to about 10% w / w of the composition, one or more volatile solvents present in an amount of about 65% to about 80% w / w of the composition, and one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 5% to about 25% w / w of the composition. In some embodiments, the ink composition further comprises one or more surfactants present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further comprises one or more surfactants present in an amount of about 2% w / w of the composition. In some embodiments, the ink composition further comprises one or more matrix components present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further comprises one or more matrix components present in an amount of about 1% to about 2% w / w of the composition. In some embodiments, the composition further comprises one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition. In some embodiments, the composition further comprises one or more preservatives present in an amount of about 1% w / w of the composition. In some embodiments, the ink composition further comprises one or more temporary colorants present in an amount of about 0.1% to about 0.5% w / w of the composition. In some embodiments, the ink composition further comprises one or more temporary colorants present in an amount of about 0.3% w / w of the composition.

[0136] In some embodiments, the ink composition comprises genipin present in an amount of about 7% w / w of the composition, one or more volatile solvents present in an amount of about 65% to about 80% w / w of the composition, and one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 5% to about 25% w / w of the composition. It includes. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 2% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 1% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.1% to about 0.5% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.3% w / w of the composition.

[0137] In some embodiments, the ink composition is genipin present in an amount of about 7% w / w of the composition, and one or more volatile solvents present in an amount of about 70% to about 75% w / w of the composition, and one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 15% w / w of the composition It includes. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 2% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 1% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.1% to about 0.5% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.3% w / w of the composition.

[0138] In some embodiments, the ink composition is genipin present in an amount of about 7% w / w of the composition, and one or more volatile solvents present in an amount of about 73% w / w of the composition, and one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 15% w / w of the composition It includes. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 2% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 1% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.1% to about 0.5% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.3% w / w of the composition.

[0139] In some embodiments, the composition is Genipin present in an amount of about 5% to about 10% w / w of the composition, and One or more volatile solvents present in an amount of about 65% to about 80% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, and one or more volatile solvents; One or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 5% to about 25% w / w of the composition and including diethylene glycol monoethyl ether It includes. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 2% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 1% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.1% to about 0.5% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.3% w / w of the composition.

[0140] In some embodiments, the ink composition is genipin present in an amount of about 7% w / w of the composition, and one or more volatile solvents present in an amount of about 70% to about 75% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, and the one or more volatile solvents; and one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 5% to about 25% w / w of the composition and including diethylene glycol monoethyl ether It includes. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 2% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 1% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.1% to about 0.5% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.3% w / w of the composition.

[0141] In some embodiments, the ink composition is genipin present in an amount of about 7% w / w of the composition, and one or more volatile solvents present in an amount of about 70% to about 75% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, and the one or more volatile solvents; one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 15% w / w of the composition and including diethylene glycol monoethyl ether It includes. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 2% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 1% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.1% to about 0.5% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.3% w / w of the composition.

[0142] In some embodiments, the ink composition is Genipin present in an amount of about 7% w / w of the composition, and one or more volatile solvents present in an amount of about 73% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, and the one or more volatile solvents; and one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 15% w / w of the composition and including diethylene glycol monoethyl ether It includes. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more surfactants present in an amount of about 2% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 3% w / w of the composition. In some embodiments, the ink composition further includes one or more matrix components present in an amount of about 1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition. In some embodiments, the composition further includes one or more preservatives present in an amount of about 1% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.1% to about 0.5% w / w of the composition. In some embodiments, the ink composition further includes one or more temporary colorants present in an amount of about 0.3% w / w of the composition.

[0143] In some embodiments, the one or more surfactants are 1,2 - hexanediol. In some embodiments, the one or more matrix components are trehalose. In some embodiments, the one or more preservatives are phenoxyethanol and ethylhexylglycerin (e.g., Euxyl® PE9010). In some embodiments, phenoxyethanol and ethylhexylglycerin are present in the composition in a ratio of 9:1 phenoxyethanol:ethylhexylglycerin. In some embodiments, the one or more temporary colorants are Acid Blue 9.

[0144] In some embodiments, the viscosity of the ink composition is about 3 to about 6 centipoise. In some embodiments, the viscosity of the ink composition is about 3.7 to about 4.1 centipoise. In some embodiments, the viscosity of the ink composition is about 3.8 centipoise.

[0145] In some embodiments, the dynamic surface tension of the ink composition is from about 25 to about 30 dynes / cm. In some embodiments, the dynamic surface tension of the ink composition is from about 25 to about 26 dynes / cm. In some embodiments, the dynamic surface tension of the ink composition is about 26 dynes / cm.

[0146] In some embodiments, the pH of the ink composition of the inkjet printer is from about 4.5 to about 5. In some embodiments, the pH of the ink composition is about 4.9. In some embodiments, the pH of the ink composition of the inkjet printer is about 4.6.

[0147] In some embodiments of the ink compositions described herein, some of the above components can be satisfied by a single component having multiple purposes. For example, in some embodiments, the skin penetration enhancer can also act as a solubilizer for the semi-volatile semi-permanent colorant. However, when indicated, if the components are listed separately in a particular embodiment of the formulation, each of the listed components is intended to be a distinct component in the composition. For example, a composition comprising one or more semi-permanent colorants, one or more volatile solvents, one or more semi-volatile semi-permanent colorant solubilizers, and one or more skin penetration enhancers contains at least four distinct components, yet each of the distinct components can potentially serve multiple, sometimes overlapping purposes.

[0148] In some embodiments of the ink compositions described herein, the composition is an ink composition of an inkjet printer configured to be printable using an inkjet printer. In some embodiments, the composition is amine-free. For example, the composition contains less than about 1% amine, such as less than about 0.8%, 0.05%, 0.02%, or about 0.01% w / w of the composition.

[0149] This specification also provides an ink composition for an inkjet printer comprising purified genipin, one or more volatile solvents, and one or more semi-volatile semi-permanent colorant solubilizers. In some embodiments, the ink composition for an inkjet printer is purified genipin present in an amount of about 7% to about 11% w / w of the composition, and one or more volatile solvents present in an amount of about 60% to about 80% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, and the one or more volatile solvents; one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 10% to about 30% w / w of the composition and comprising diethylene glycol monoethyl ether; one or more surfactants present in an amount of about 0.25% to about 5% w / w of the composition; one or more matrix components present in an amount of about 0.1% to about 5% w / w of the composition and comprising.

[0150] In some embodiments, the ink composition for an inkjet printer is purified genipin present in an amount of about 7% to about 11% w / w of the composition, and one or more volatile solvents present in an amount of about 65% to about 75% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, and the one or more volatile solvents; one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 15% to about 25% w / w of the composition and comprising diethylene glycol monoethyl ether; one or more surfactants present in an amount of about 0.25% to about 5% w / w of the composition; one or more matrix components present in an amount of about 0.5% to about 3.5% w / w of the composition and can comprise.

[0151] In some embodiments, the ink composition for an inkjet printer can further comprise one or more of a skin penetration enhancer, a temporary colorant, and a preservative.

[0152] In some embodiments, the ink composition of the inkjet printer is configured to have a pH of about 4 to about 7. For example, about 4 to about 5, about 4.5 to about 5.5, about 5 to about 6, about 5.5 to about 6.5, or about 6 to about 7. In some embodiments, the ink composition of the inkjet printer has a pH of about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, or about 7.

[0153] In some embodiments, the ink composition of the inkjet printer has a pH of about 4 to about 7. For example, about 4 to about 5, about 4.5 to about 5.5, about 5 to about 6, about 5.5 to about 6.5, or about 6 to about 7. In some embodiments, the ink composition of the inkjet printer has a pH of about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, or about 7.

[0154] In some embodiments, the composition is amine-free. For example, the ink composition of the inkjet printer contains less than about 1% amine, such as less than about 0.8%, about 0.05%, about 0.02%, about 0.01%, or about 0.005% w / w of the composition.

[0155] In some embodiments, the ink composition of the inkjet printer purified genipin present in an amount of about 9% w / w of the composition, and one or more volatile solvents present in an amount of about 67% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, and one or more volatile solvents; one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 21% w / w of the composition and containing diethylene glycol monoethyl ether; one or more surfactants present in an amount of about 1% w / w of the composition, wherein the surfactant is PEG400; one or more matrix components present in an amount of about 2% w / w of the composition, wherein the matrix component is trehalose It includes. In some embodiments, the viscosity of the ink composition of the inkjet printer is about 4.5 centipoises. In some embodiments, the dynamic surface tension of the ink composition of the inkjet printer is about 30 dynes / cm. In some embodiments, the pH of the ink composition of the inkjet printer is about 4.9.

[0156] In some embodiments, the ink composition of the inkjet printer purified genipin present in an amount of about 9% w / w of the composition, one or more volatile solvents present in an amount of about 67% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, and the one or more volatile solvents; one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 21% w / w of the composition and including diethylene glycol monoethyl ether; one or more surfactants present in an amount of about 1% w / w of the composition, and the one or more surfactants are PEG400; one or more matrix components present in an amount of about 2% w / w of the composition, and the one or more matrix components are trehalose; one or more colorants present in an amount of about 0.2% w / w of the composition, and the one or more temporary colorants are FD&C Blue No. 1 It includes. In some embodiments, the viscosity of the ink composition of the inkjet printer is about 4.5 centipoises. In some embodiments, the dynamic surface tension of the ink composition of the inkjet printer is about 30 dynes / cm. In some embodiments, the pH of the ink composition of the inkjet printer is about 4.9.

[0157] In some embodiments, the ink composition of the inkjet printer purified genipin present in an amount of about 4.5% w / w of the composition, One or more volatile solvents present in an amount of about 70% w / w of the composition, wherein the one or more semi-volatile solvents are water and ethanol, and the one or more volatile solvents, One or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 22.5% w / w of the composition and comprising diethylene glycol monoethyl ether, One or more surfactants present in an amount of about 1% w / w of the composition, wherein the surfactant is PEG400, One or more matrix components present in an amount of about 2% w / w of the composition, wherein the matrix component is trehalose, One or more temporary colorants present in an amount of about 0.1% w / w of the composition, wherein the colorant is FD&C Blue No. 1 and the like. In some embodiments, the viscosity of the ink composition of the inkjet printer is about 4.5 centipoise. In some embodiments, the dynamic surface tension of the ink composition of the inkjet printer is about 30 dynes / cm. In some embodiments, the pH of the ink composition of the inkjet printer is about 4.9.

[0158] Also provided herein are applicator articles comprising a composition, an adhesive, and an adhesive backing as described in any of the above embodiments.

[0159] In some embodiments, the adhesive applicator article described herein can further comprise a non-adhesive liner.

[0160] In some embodiments, the adhesive applicator article can further comprise a heat pad or be configured to be used with a heat pad.

[0161] In some embodiments of the adhesive applicator article described herein, the ink composition as described in any of the above embodiments is disposed and / or bonded to at least a portion of the adhesive. In some embodiments of the adhesive applicator article described herein, the ink composition is dried on the applicator article. For example, after the composition is printed on the adhesive, the composition can be dried by heating. In some examples, the material can be heated and / or dried using an oven, a double convection oven, a conveyor, and / or an infrared oven. In some embodiments, the composition is dried at about 40°C to about 80°C. For example, about 40°C to about 50°C, about 45°C to about 55°C, about 50°C to about 60°C, about 55°C to about 65°C, about 60°C to about 70°C, about 65°C to about 75°C, or about 70°C to about 80°C. In some embodiments, the composition is dried at about 50°C, about 55°C, about 60°C, about 65°C, about 70°C, or about 75°C. In some embodiments, the composition is dried for a certain period of time. For example, the composition can be dried for about 0.25 to about 3 hours. In some embodiments, the composition is dried for about 0.25 hours to about 0.75 hours, about 0.5 hours to about 1 hour, about 0.75 hours to about 1.25 hours, about 1 hour to about 1.5 hours, about 1.25 hours to about 1.75 hours, about 1.5 hours to about 2 hours, about 1.75 hours to about 2.25 hours, about 2 hours to about 2.5 hours, about 2.25 hours to about 2.75 hours, or about 2.5 hours to about 3 hours. In some embodiments, the composition is dried for about 0.5 hours, about 1 hour, about 1.5 hours, about 2 hours, about 2.5 hours, or about 3 hours. In some embodiments, the composition is dried at about 55°C to about 65°C for about 1.25 hours to about 1.75 hours. In some embodiments, the composition is dried at about 60°C for about 1.5 hours. In some embodiments, the composition is dried at about 60°C for about 1 hour.

[0162] In some embodiments, the adhesive applicator article described herein can further include a pharmaceutical or cosmetic for delivery to a subject. In some embodiments, the adhesive applicator article can include a patch for delivering a pharmaceutical or cosmetic. In some embodiments, the composition is printed on the patch.

[0163] FIG. 1 shows an adhesive applicator article 1 according to one embodiment of the present disclosure. As shown in FIG. 1, in some embodiments, the adhesive applicator article includes an adhesive layer 20, an adhesive backing 30, and an ink composition 60, such as the ink composition described in the above embodiments. In some embodiments, the adhesive applicator article optionally further includes a liner 10. The liner 10 can be, for example, a protective liner and / or a non-sticky liner.

[0164] The adhesive layer 20 can include a first surface 21 and a second surface 22 opposite the first surface. In the illustrated embodiment, the adhesive layer 20 is shown with its second surface 22 disposed and / or bonded on the first surface of the adhesive backing 30. The first surface 21 and the second surface 22 of the adhesive layer 20 are further described herein in connection with FIG. 2B, and further, the first surface and the second surface of the adhesive backing 30 are further described herein in connection with FIG. 2B.

[0165] The above ink composition 60 is adhered and / or bonded onto the first surface 21 of the adhesive layer 20. In some embodiments, the ink composition 60 is adhered and / or bonded to a portion of the first surface 21 of the adhesive layer 20. In some embodiments, the ink composition 60 is printed onto the first surface 21 of the adhesive layer 20, for example, via inkjet printing. In some embodiments where the ink composition 60 is adhered and / or bonded to a portion of the first surface 21 of the adhesive layer 20, the ink composition 60 is printed onto the first surface 21 of the adhesive layer 20 in any number of designs. For example, the ink composition 60 can be printed as a pattern, shape, word, picture, image or art created by the user, or a combination of two or more of them. In some embodiments, multiple layers of the ink composition 60 can be printed onto the first surface 21 of the adhesive layer 20 to create a desired pattern and / or effect.

[0166] In some optional embodiments where the adhesive applicator article further includes the liner 10, the liner 10 is adhered and / or bonded onto the ink composition 60. In some embodiments where the adhesive applicator article further includes the liner 10, the liner 10 is adhered and / or bonded onto the ink composition 60 and the first surface 21 of the adhesive layer 20, and the ink composition 60 is adhered and / or bonded to a portion of the first surface 21 of the adhesive layer 20. In some embodiments, the liner 10 is a non-adhesive liner.

[0167] In some embodiments, the adhesive applicator article 1 is configured to provide a suitable structure for the printing, manufacturing, storage, and / or application of a composition containing a semi-permanent colorant as described herein. In some embodiments, the adhesive applicator article 1 is configured to provide a suitable structure for eliminating or reducing the risk that the adhesive folds onto itself during application, for example, and / or for improving the ease of application by the user to the surface of the applicator article, such as the skin surface.

[0168] In some embodiments, the adhesive applicator article 1 further optionally includes a heat pad. In some embodiments, the heat pad is adhered to the second surface of the adhesive backing 30. In some embodiments, the heat pad is not coupled to the adhesive applicator article 1 and is placed on the second surface of the adhesive backing 30 by the user while applying the ink composition 60 to the skin.

[0169] FIG. 2A shows an exploded perspective view of an adhesive applicator article 100 according to another embodiment of the present disclosure. FIG. 2B shows a side view of the adhesive applicator article 100. As shown in FIG. 2A, in some embodiments, the adhesive applicator article 100 includes a first adhesive layer 120, a first backing 130 (which may be similar to the adhesive backing 30 described in connection with FIG. 1), a second adhesive layer 140, and a second backing 150. In some embodiments, the adhesive applicator article 100 further optionally includes a liner 110. In some embodiments, the adhesive applicator article 100 further optionally includes an ink composition, such as the ink composition described above.

[0170] As shown in FIG. 2B, the first adhesive layer 120 can include a first surface 121 and a second surface 122 opposite the first surface 121. The first adhesive layer 120 is shown with the second surface 122 disposed and / or bonded on the first surface 131 of the first backing 130. The second surface 132 of the first backing 130 can be disposed and / or bonded on the first surface 136 of the second adhesive layer 140. The second surface 138 of the second adhesive layer 140 is shown disposed and / or bonded on the first surface 151 of the second backing 150, and the first surface 151 of the second backing 150 is opposite the second surface 152 of the second backing 150.

[0171] In some embodiments, the first adhesive layer 120 can optionally have a backing disposed and / or bonded on its second surface 122. In some embodiments, the first backing 130 can optionally have an adhesive layer disposed and / or bonded on its first surface 131, its second surface 132, or both. In some embodiments, the first backing 130 has an adhesive layer disposed and / or bonded on its first surface 131 and its second surface 132, and the adhesive layer disposed and / or bonded on its first surface 131 can be a stronger adhesive than the adhesive layer disposed and / or bonded on its second surface 132. For example, in some embodiments, a weaker peel strength is adhered to the first adhesive layer 120 and a stronger adhesive is adhered to the second backing 150, such that the second backing 150 can be easily removed without leaving a residue. In some embodiments, the second adhesive layer 140 can optionally have a backing disposed and / or bonded on its first surface 136, its second surface 138, or both, as shown in FIG. 2B. In some embodiments, the second backing 150 can optionally have an adhesive layer disposed and / or bonded on its first surface 151. In some embodiments, the second backing 150 has an adhesive layer disposed and / or bonded on its first surface 151 and its second surface 152, and the second adhesive layer 140 disposed and / or bonded on its first surface 151 can be a stronger adhesive than the adhesive layer disposed and / or bonded on its second surface 152. In some embodiments, the second backing 150 has an adhesive layer disposed and / or bonded on its first surface 151 and its second surface 152, and the liner can be disposed and / or bonded on the second surface 152 of the second backing 150.

[0172] In some embodiments, an ink composition, such as the above-described ink composition, can adhere and / or bond to at least a portion of the first surface 121 of the first adhesive layer 120. In some embodiments, the ink composition can adhere and / or bond to a portion of the first surface 121 of the first adhesive layer 120. In some embodiments, the ink composition is printed on the first surface 121 of the first adhesive layer 120. In some embodiments, the ink composition can be printed on the first surface 121 of the first adhesive layer 120 using an inkjet printer. In some embodiments where the ink composition is adhered and / or bonded to a portion of the first surface 121 of the first adhesive layer 120, the ink composition can be printed on the first surface 121 of the first adhesive layer 120 in any number of designs. For example, the ink composition can be printed as a pattern, shape, word, picture, image or art created by a user, or a combination of two or more of them. Examples of patterns, words, pictures, images, and / or art created by a user are mentioned herein, but the embodiments are not so limited. For example, among other effects, it is possible to print a three-dimensional gradient of a shape (e.g., a substantially solid ink distribution), a deformation gradient of a shape, and various thicknesses of lines. In some embodiments, multiple layers of the ink composition can be printed on the first surface 121 of the first adhesive layer 120 to create a desired pattern and / or effect.

[0173] In some embodiments, the second adhesive 140 and the second backing 150 are disposed and / or bonded to at least a portion of the second surface 132 of the first backing 130. In some embodiments, a portion of the surface can include a perimeter, a portion of the perimeter, a grid, a section, etc.

[0174] As shown in FIG. 2A, in some embodiments, each layer can optionally be composed of a plurality of parts or portions. For example, the second adhesive 140 and the second backing 150 can be divided into two or more parts, such as part 140a and part 140b of the second adhesive 140, and part 150a and part 150b of the second backing 150. In some embodiments, the two or more parts can have an overlapping arrangement, can be adjacent to each other, can be separated by a distance, or can be a combination thereof. A part can include a perimeter, a part of the perimeter, a grid, a section, etc.

[0175] In some embodiments where the applicator article 100 further includes a liner 110 and an ink composition (e.g., the ink composition 60 described above in connection with FIG. 1), the liner 110 can be disposed on and / or bonded to the ink composition. In some embodiments where the adhesive applicator article 100 further includes a liner 110 and an ink composition as described above, the liner 110 can be disposed on and / or bonded to the ink composition and the first surface 121 of the first adhesive layer 120, and the ink composition is adhered and / or bonded to a part of the first surface 121 of the first adhesive layer 120. In some embodiments, the liner 110 is a non-adhesive liner. In some embodiments, the liner 110 can be coated with a silicone coating, a fluorosilicone coating, a wax coating, a non-stick polymer, or a similarly non-stick layer. In some embodiments, the liner 110 can be a silicone-coated paper liner.

[0176] In some embodiments, the first adhesive layer 120 can include an acrylic adhesive, a rubber adhesive, or other suitable adhesives configured to receive an ink composition, dry it, and allow at least a portion of the composition to be released and penetrate onto and / or into the skin of the user to whom it is applied.

[0177] In some embodiments, the first backing 130 can be, for example, a polyurethane backing or other suitable backing configured to provide a desired structure, strength, or shape to the adhesive applicator article. In some embodiments, the first backing 130 can reduce and / or eliminate the tackiness of an adjacent adhesive layer. For example, the first backing 130 can reduce and / or eliminate the tackiness of the first adhesive layer 120. In some embodiments, the first backing 130 can increase the rigidity of the adhesive applicator article 100 during manufacture and / or use.

[0178] In some embodiments, the second adhesive layer 140 can be a laminate adhesive.

[0179] In some embodiments, the second backing 150 can be, for example, a polycarbonate backing configured to provide a desired structure, strength, or shape to the adhesive applicator article 100. In some embodiments, the second backing 150 can provide a structure that suppresses or prevents wrinkles in the adhesive during the application period.

[0180] In some embodiments, the adhesive applicator article 100 is configured to provide a suitable structure for the printing, manufacture, storage, and / or application of a composition containing a semi-permanent colorant as described herein.

[0181] Figure 3 shows an adhesive applicator article 200 according to another embodiment of the present disclosure. As shown in Figure 3, in some embodiments, the adhesive applicator article 200 includes an adhesive layer 220, a backing 230, and a structural layer 240. In some embodiments, the adhesive applicator article 200 optionally further includes a liner 210. In some embodiments, the adhesive applicator article 200 optionally further includes an ink composition (e.g., the ink composition 60 described above in connection with Figure 1). The adhesive layer 220 may be similar to the adhesive layer 20, the adhesive layer 120, and / or the second adhesive layer 140, as described respectively in connection with Figures 1, 2A, and 2B in some examples. The backing 230 may be similar to the adhesive backing 30, the backing 130, and / or the second backing 150, as described respectively in connection with Figures 1, 2A, and 2B in some examples. The liner 210 may be similar to the liner 10 and / or the liner 110, as described respectively in connection with Figures 1, 2A, and 2B in some examples.

[0182] Although not specifically labeled in Figure 3, so as not to impede the examples of the present disclosure, the adhesive layer 220 can include a first surface and a second surface opposite the first surface, as described in connection with Figure 2B. Although not specifically labeled in Figure 3, so as not to interfere with the examples of the present disclosure, the backing 230 can include a first surface and a second surface opposite the first surface, as described in connection with Figure 2B. The adhesive layer 220 is shown together with its second surface disposed and / or bonded on the first surface of the backing 230. The second surface of the backing 230 is disposed and / or bonded on the first surface of the structural layer 240.

[0183] In some embodiments, the adhesive layer 220 can optionally have a backing disposed and / or bonded on its second surface. In some embodiments, the backing 230 can optionally have an adhesive layer disposed and / or bonded on its first surface, its second surface, or both. In some embodiments, the structural layer 240 can optionally have an adhesive layer disposed and / or bonded on its first surface, its second surface, or both.

[0184] In some embodiments, the backing 230 is laminated on the adhesive layer 220.

[0185] In some embodiments, the ink composition (e.g., the ink composition 60 described above in connection with FIG. 1) is adhered and / or bonded to at least a portion of the first surface of the adhesive layer 220. In some embodiments, the ink composition is adhered and / or bonded to a portion of the first surface of the adhesive layer 220. In some embodiments, the ink composition is printed on the first surface of the adhesive layer 220. In some embodiments, an inkjet printer can be used to print the ink composition on the first surface of the adhesive layer 220. In some embodiments where the ink composition is adhered and / or bonded to a portion of the first surface of the adhesive layer 220, the ink composition is printed on the first surface of the adhesive layer 220 in any number of designs. For example, the ink composition can be printed as a pattern, shape, word, picture, image or art created by a user, or a combination of two or more thereof. In some embodiments, multiple layers of the ink composition can be printed on the first surface of the adhesive layer 220 to create a desired pattern and / or effect.

[0186] In some embodiments, the structural layer 240 is disposed and / or coupled to a portion of the backing 230. In some embodiments, the liner 210 functions as an additional structural layer. For example, the liner 210 can be a framing. In some embodiments, a portion of the surface can include a perimeter, a portion of the perimeter, and grids, sections, etc. In some embodiments, the structural layer 240 and / or the liner 210 can be kiss cut. For example, a die cut that penetrates only the structural layer. In some embodiments, the inner corners of the structural layer 240 are rounded. The rounded corners can, for example, prevent tearing during removal and / or provide an indication to the user as to where to remove the applicator.

[0187] In some embodiments, one or more layers of the adhesive article 200 can be composed of two or more parts or portions. In some embodiments, the two or more parts can have an overlapping arrangement, can be adjacent to each other, or the two or more parts can be a combination thereof. In some embodiments, the two or more parts are part of adjacent layers. The part can include a perimeter, a portion of the perimeter, and grids.

[0188] In some embodiments where the adhesive applicator article 200 optionally further includes a liner 210 and an ink composition (e.g., the ink composition described above in connection with FIG. 1), the liner 210 is disposed and / or bonded on the ink composition 260. In some embodiments where the adhesive applicator article further includes a liner 210 and the above-described composition 260, the liner 210 is disposed and / or bonded on the first surface of the ink composition 260 and the adhesive layer 220, and the ink composition is adhered and / or bonded to a portion of the first surface of the adhesive layer 220. In some embodiments, the liner 210 is a non-adhesive liner. For example, in some embodiments, the liner 210 can be coated with a silicone coating, a fluorosilicone coating, a wax coating, a non-stick polymer, or a similarly non-stick layer. In some embodiments, the liner 210 can be a silicone-coated paper liner. In some embodiments, the liner 210 can be a fluorosilicone-coated paper liner.

[0189] In some embodiments, the adhesive layer 220 can be an acrylic adhesive, a rubber adhesive, or other suitable adhesive configured to receive an ink composition, dry it, and allow at least a portion of the composition to be released and penetrate onto and / or into the skin of the user to whom it is applied.

[0190] In some embodiments, the backing 230 can be, for example, a polyurethane backing or other suitable backing configured to provide a desired structure, strength, or shape to the article. In another example, the polyurethane carrier can provide a desired structure, water vapor transmission properties, and porosity. In some embodiments, the backing 230 can reduce and / or eliminate the adhesiveness of the adjacent adhesive layer. For example, the backing 230 can reduce and / or eliminate the adhesiveness of the adhesive layer 220. In some examples, the adhesive layer 220 can be an acrylic adhesive, a rubber adhesive, or other suitable adhesive. In some embodiments, the backing 230 can increase the rigidity of the adhesive applicator article 200 during manufacturing and / or use. In addition to or instead of increasing the rigidity, the backing 230 can be permeable. When the backing 230 is permeable, the user can see the design formed by the ink composition (e.g., the ink composition 60 of FIG. 1). In some examples, when the backing 230 is permeable, the backing 230 can allow for an increase in breathability between the user's skin and the external environment.

[0191] In some embodiments, the adhesive applicator article 200 is configured to provide a suitable structure for the printing, manufacturing, storage, and / or application of a composition comprising a semi-permanent colorant as described herein.

[0192] FIG. 4 shows an adhesive applicator article according to another embodiment of the present disclosure. As shown in FIG. 4, in some embodiments, the adhesive applicator article 400 includes a first adhesive layer 420, a first backing 430, a second adhesive layer 440, and a second backing 450. The first adhesive layer 420 may be similar to the adhesive layer 20, the first adhesive layer 120, and / or the adhesive layer 220, respectively, described in connection with FIGS. 1, 2A, 2B, and / or 3 in some examples. The liner 410 may be similar to the liner 10, the liner 110, and / or the liner 210, respectively, described in connection with FIGS. 1, 2A, 2B, and / or 3 in some examples. The first backing 430 may be similar to the adhesive backing 30, the first backing 130, and / or the backing 230, respectively, described in connection with FIGS. 1, 2A, 2B, and / or 3 in some examples. The second adhesive layer 440 may be similar to the adhesive layer 20, the second adhesive layer 140, and / or the adhesive layer 220, respectively, described in connection with FIGS. 1, 2A, 2B, and / or 3 in some examples. The second backing 450 may be similar to the adhesive backing 30, the second backing 150, and / or the backing 230, respectively, described in connection with FIGS. 1, 2A, 2B, and / or 3 in some examples.

[0193] In some embodiments, the second backing 450 is strongly adhered to the second adhesive layer 440 such that its removal during application is prevented. In some embodiments, the second backing 450 can provide a structure that prevents wrinkling of the adhesive layer (e.g., the first adhesive layer 420 and / or the second adhesive layer 440) during the application period. In some embodiments, the second adhesive layer 440 is part of the first backing 430. In some embodiments, the second backing 450 is part of the first backing 430. In some embodiments, the second adhesive layer 440 and the second backing 450 are part of the first backing 430. In some embodiments, a portion of the surface (e.g., the first portion 140a and / or the second portion 140b associated with FIG. 2A) can include a perimeter, a portion of the perimeter, a grid, a section, etc. In some embodiments, the portion is, for example, a honeycomb pattern as shown in FIG. 4.

[0194] FIG. 12 is an exploded perspective view of an adhesive applicator article 1200 according to another embodiment of the present disclosure. FIG. 12 shows a first liner 1210a, a second liner 1210b, an adhesive layer 1220, and a backing 1230. The first liner 1210a and / or the second liner 1210b can be similar to the liners 10, liner 110, liner 210, and / or liner 410 described in connection with FIGS. 1, 2A, 2B, 3, and 4, respectively, in some examples. The adhesive layer 1220 can be similar to the adhesive layers 20, the first adhesive layer 120, the second adhesive layer 140, the adhesive layer 220, the first adhesive layer 420, and / or the second adhesive layer 440 described in connection with FIGS. 1, 2A, 2B, 3, and 4, respectively, in some examples. The backing 1230 can be similar to the adhesive backing 30, the first backing 130, the backing 230, and / or the first backing 430 described in connection with FIGS. 1, 2A, 2B, 3, and 4, respectively, in some examples.

[0195] In some embodiments, the first liner 1210a may be removable. For example, the first liner 1210a can be removed by the user during the coating process. For example, the user can position the adhesive applicator article 1200 and remove the first liner 1210a to expose the ink composition (e.g., the ink composition 60 of FIG. 1). In some embodiments, the second liner 1210b can be made of a material that can provide some rigidity. For example, the second liner 1210b can be a liner made of a material that can provide a structural boundary to the adhesive applicator article 1200. For example, the ink composition can be part of an adhesive layer that can be surrounded by a structural boundary in the form of the second liner 1210b. The second liner 1210b can be configured to eliminate or reduce the risk of the adhesive, including, for example, the ink composition folding onto itself during application, and / or to provide a suitable structure to improve the ease of application by the user to the surface of the applicator article, such as the skin surface.

[0196] The backing 1230 can be, in some embodiments, for example, a polyurethane (PU) backing or other suitable backing configured to provide a desired structure, strength, or shape to the adhesive applicator article 1200. In some examples, the PU backing 1230 can include a thickness of 1 mil. In other examples, the PU backing 1230 can include a thickness of 2.4 mils. However, embodiments are not so limited, and the backing 1230 can be more or less than 1 mil or 1.4 mils. In some embodiments, the backing 1230 can reduce and / or eliminate the adhesiveness of an adjacent adhesive layer. For example, the backing 1230 can reduce and / or eliminate the adhesiveness of the adhesive layer 1220. In some embodiments, the backing 1230 can increase the rigidity of the adhesive applicator article 1200 during manufacturing and / or use. By increasing the rigidity, the risk of damage to the design formed by the ink composition can be reduced. In some exemplary embodiments, the backing 1230 can be composed of a transparent material.

[0197] Figure 13 is another exploded perspective view of an adhesive applicator article 1300 according to another embodiment of the present disclosure. The adhesive applicator article 1300 can be an occlusion patch article and is referred to herein as the occlusion patch article 1300. Figure 13 shows the occlusion patch article 1300. The occlusion patch can be used with another adhesive applicator article such as the adhesive applicator article 1200 described in connection with Figure 12. For example, the adhesive applicator article 1300 can be positioned on top of the adhesive applicator article 1200 to contain moisture and heat during the application process. For example, the occlusion patch can include dimensions larger than the adhesive applicator article 1200 so that it can adhere to the skin around the adhesive applicator article 1200. As shown in Figure 13, in some embodiments, the occlusion patch article 1300 includes a liner 1310, an adhesive layer 1320, a backing 1330, and a structural layer 1340. The liner 1310 can be similar in some respects to the liners 10, liner 110, liner 210, liner 410, first liner 1210a, and / or second liner 1210b described in connection with Figures 1, 2A, 2B, 3, 4, and 12, respectively. The adhesive layer 1320 can be similar in some examples to the adhesive layers 20, first adhesive layer 120, second adhesive layer 140, adhesive layer 220, first adhesive layer 420, second adhesive layer 440, and / or adhesive layer 1220 described in connection with Figures 1, 2A, 2B, 3, 4, and 12, respectively. The backing 1330 can be similar in some examples to the adhesive backings 30, first backing 130, second backing 150, backing 230, first backing 430, and / or backing 1230 described in connection with Figures 1, 2A, 2B, 3, 4, and 12, respectively.

[0198] In some embodiments, the liner 1310 may be removable. For example, the liner 1310 can be removed by the user during the application process. For example, the user can position the adhesive applicator article 1300 and remove the liner 1310 to expose the ink composition (e.g., the ink composition 60 of FIG. 1). In another example, after the user removes the liner from the first liner 1210a, the user can position the adhesive applicator article 1200 and proceed to position the occlusion patch article 1300 on top of the adhesive applicator article 1200.

[0199] In some embodiments, the adhesive layer 1320 can be a double-sided adhesive layer 1320. For example, the adhesive layer 1320 can have a first surface 1321 and a second surface 1322. The first surface 1321 can be adjacent to or otherwise coupled to the liner 1320, and the second surface 1322 is on the opposite side of the first surface 1321 and can be adjacent to or otherwise in contact with the backing 1330. If the adhesive layer 1320 is double-sided, the adhesive can be disposed on both the first surface 1321 and the second surface 1322.

[0200] In some embodiments, the backing 1330 is made of a transparent material. If the backing 1330 is transmissive, the user can view the design formed by the ink composition (e.g., the ink composition 60 of FIG. 1). In some examples, if the backing 1330 is transmissive, the backing 1330 can allow for an increase in breathability between the user's skin and the external environment.

[0201] The structural layer 1340 can be part of the occlusive patch article 1300 that can provide a flexible frame for the ink composition design. The structural layer 1340 can be a support for protecting the ink composition design and providing structure to the occlusive patch article 1300. In some embodiments, the liner 1310 can be removable and / or can be kraft paper coated with silicone on the first surface 1321. In some embodiments, the double-sided adhesive layer 1320 can be a rubber synthetic adhesive such that the first surface 1321 adheres to the removable liner 1310 and the second surface 322 adheres to the transparent backing 1330. In some embodiments where the backing 1330 is permeable, the backing 1330 can be polyurethane with a thickness of 0.5 mil to 3.0 mils. In some embodiments, the layer 340 can be a roll label frame that adheres around the transparent layer 330 with a thickness of 2 to 5 mils.

[0202] In some embodiments, the occlusive patch article 1300 will have larger dimensions compared to other embodiments discussed herein. For example, the occlusive patch article 1300 can have dimensions larger than the adhesive applicator article 100 described in relation to FIGS. 2A and 2B. For example, the occlusive patch article 1300 can include dimensions larger than the adhesive applicator article 100 such that it can adhere to the skin surrounding the adhesive applicator article 100. In some embodiments, when the applicator article 1300 adheres to the skin, the removable liner 1310 is removed, and the first surface 1321 of the adhesive layer 1320 is exposed so that it can adhere to the skin. The occlusive patch article 1300 can surround the adhesive layer and / or layers containing the ink composition.

[0203] Figures 14A, 14B, and 14C are perspective views of an adhesive applicator article 1400 according to an embodiment of the present disclosure. FIG. 14A is a top view of the front and back of the adhesive applicator article 1400, FIG. 14B is an exploded view of the adhesive applicator article 1400, and FIG. 14C is an example of the dimensions of the adhesive applicator article 1400. The exemplary adhesive applicator 1400 can be an example of an occlusion patch article (e.g., the occlusion patch article 1300 described in connection with FIG. 13) in which a stack-up 1460 is embedded.

[0204] FIG. 14A shows a top view of the front and back of the adhesive applicator article 1400. The adhesive applicator article 1400 includes a backing 1430. In some examples, the backing 1430 is a polyurethane (PU) backing. For example, the backing 1430 can be a 1-mil PU backing. The adhesive applicator article 1400 can include an adhesive layer 1420. In some examples, the adhesive layer 1420 is a double-sided adhesive that can adhere to the backing 1430 and the stack-up 1460. The stack-up 1460 can include an adhesive layer, a double-sided adhesive layer, and a 1-mil PU backing. The stack-up can be positioned on a liner 1410. In some embodiments, the liner 1410 is a fluorosilicone (FS) liner. The liner 1410 and / or the border 1412 can be removed by the user to expose the stack-up 1460 to the user's skin. The liner can be coupled to and / or otherwise positioned at the border 1412. The border 1412 can provide not only a structure to the adhesive applicator article 1400 but also a guide for the user. The adhesive applicator article 1400 can further include a pull tab 1430 to facilitate removal of the border 1412. For example, the pull tab 1413 can facilitate removal of the border 1410. After removing the border 1410 using the pull tab 1413, the user can remove the liner 1410. The liner 1410 can facilitate the storage and / or shelf life of the ink composition.

[0205] Figure 14B shows an exploded view of the adhesive applicator article 1400. The exploded view shows examples of the different elements of the adhesive applicator article 1400. In this case, the adhesive applicator article 1400 includes a backing (e.g., 1 mil PU backing) for bonding to the adhesive layer 1420 (e.g., a double-sided adhesive layer 1420) for bonding to the stack-up 1460. The stack-up 1460 can be bonded to a liner 1410 (e.g., an FS liner), and this can be removed to expose the stack-up 1460 to the user's skin. The border 1412 provides structure to the adhesive applicator article 1400 and can facilitate positioning and adhesion to the user's skin, and / or handling and positioning on the user's skin.

[0206] Figure 14C includes design examples including measurement examples. Specific numbers are shown in Figure 14, but the embodiments are not so limited. A plurality of different dimensions are considered, and there may be more or fewer dimensions than those shown in Figure 14. As mentioned herein, the occlusive patch article can have larger dimensions in some embodiments compared to other embodiments discussed herein. For example, the occlusive patch article (e.g., the adhesive applicator article 1400) can have larger dimensions than the adhesive applicator article 1200 described in connection with Figure 12.

[0207] The adhesive applicator article 1400 can be a combination of the adhesive applicator article 1200 and the adhesive applicator article 1300. Combining these two adhesive applicator articles can reduce the waste, performance issues, and user errors associated with positioning the article 1200 on top of the article 1300. Combining the two articles can reduce the possibility of wrinkles and user errors.

[0208] The embodiment shown in FIG. 14C includes an adhesive layer (e.g., adhesive layer 1420 in FIGS. 14A and 14B) including a boundary having a dimension of 1.0 inch (inch) (e.g., boundary portion 1412 in FIGS. 14A and 14B), a dimension of 0.85 inch, and a dimension of 0.65 inch, and a stack-up (e.g., stack-up 1460 in FIGS. 14A and 14B). The adhesive layer and / or the stack-up can include a design including an ink composition (e.g., ink composition 60 as described above in connection with FIG. 1). The boundary portion can have a radius of curvature (R) R = 0.15 inch, the adhesive layer can have a radius of curvature R = 0.06 inch, and the stack-up can have a radius of curvature R = 0.06 inch.

[0209] FIGS. 15A, 15B, and 15C are perspective views of an adhesive applicator article 1500 according to an embodiment of the present disclosure. FIG. 15A is a top view of the front and back of the adhesive applicator article 1500, FIG. 15B is an exploded view of the adhesive applicator article 1500, and FIG. 15C is an example of the dimensions of the adhesive applicator article 1500. An exemplary adhesive applicator 1500 can be an example of a closed patch article (e.g., closed patch article 1300 described in connection with FIG. 13) in which a stack-up 1560 is embedded.

[0210] FIG. 15A shows a front and rear top view of an adhesive applicator article 1500. The adhesive applicator article 1500 includes a backing 1530. In some examples, the backing 1530 is a PU backing. For example, the backing 1530 can be a 1 mil PU backing. The adhesive applicator article 1500 can include an adhesive layer 1520. In some examples, the adhesive layer 1520 is a double-sided adhesive that can adhere to the backing 1530 and the stack-up 1560. The stack-up 1560 can include an adhesive layer, a double-sided adhesive layer, and a 1 mil PU backing. The stack-up can be positioned on a liner 1510. In some embodiments, the liner 1510 is an FS liner. The liner 1510 and / or the border 1512 can be removed by a user to expose the stack-up 1560 to the user's skin. The liner can be coupled and / or otherwise positioned to the border 1512. The border 1512 can provide not only a structure to the adhesive applicator article 1500 but also a guide for the user. The adhesive applicator article 1500 can further include a pull tab 1530 to facilitate removal of the border 1512. For example, the pull tab 1513 can facilitate removal of the border 1510. After removing the border 1510 using the pull tab 1513, the user can remove the liner 1510. The liner 1510 can facilitate the storage and / or shelf life of the ink composition.

[0211] FIG. 15B shows an exploded view of the adhesive applicator article 1500. The exploded view shows examples of different elements of the adhesive applicator article 1500. In this case, the adhesive applicator article 1500 includes a backing (e.g., 1 mil PU backing) for attachment to the adhesive layer 1520 (e.g., a double-sided adhesive layer 1520) for attachment to the stack-up 1560. The stack-up 1560 can be attached to a liner 1510 (e.g., an FS liner), which can be removed to expose the stack-up 1560 to the user's skin. The border 1512 provides structure to the adhesive applicator article 1500 and can facilitate positioning and attachment to the user's skin and / or handling and positioning on the user's skin.

[0212] FIG. 15C includes design examples including measurement examples. Although specific numbers are shown in FIG. 15, the embodiments are not so limited. A plurality of different dimensions are considered and there may be more or fewer dimensions than those shown in FIG. 15. As referred to herein, the occlusion patch article can have larger dimensions in some embodiments as compared to other embodiments discussed herein. For example, the occlusion patch article (e.g., the adhesive applicator article 1500) can have larger dimensions than the adhesive applicator article 1200 described in connection with FIG. 12.

[0213] The adhesive applicator article 1500 can be a combination of the adhesive applicator article 1200 and the adhesive applicator article 1300. Combining these two adhesive applicator articles can reduce the waste, performance issues, and user errors associated with positioning the article 1200 on top of the article 1300. Combining the two articles can reduce the possibility of wrinkles and user errors.

[0214] The embodiment shown in FIG. 15C includes an adhesive layer (e.g., adhesive layer 1520 in FIGS. 15A and 15B) having a boundary (e.g., boundary portion 1512 in FIGS. 15A and 15B) with a dimension of 2.0 inches (inches), a dimension of 1.7 inches, and a dimension of 1.4 inches, and a stack-up (e.g., stack-up 1560 in FIGS. 15A and 15B). The adhesive layer and / or the stack-up can include a design that includes an ink composition (e.g., ink composition 60 as described above in connection with FIG. 1). The boundary portion can have a radius of curvature (R) R = 0.25 inches, the adhesive layer can have a radius of curvature R = 0.1 inches, and the stack-up can have a radius of curvature R = 0.1 inches.

[0215] FIGS. 16A, 16B, and 16C are perspective views of an adhesive applicator article 1600 according to an embodiment of the present disclosure. FIG. 16A is a top view of the front and back of the adhesive applicator article 1600, FIG. 16B is an exploded view of the adhesive applicator article 1600, and FIG. 16C is an example of the dimensions of the adhesive applicator article 1600. An exemplary adhesive applicator 1600 can be an example of a closed patch article (e.g., closed patch article 1300 described in connection with FIG. 13) in which a stack-up 1660 is embedded.

[0216] FIG. 16A shows front and back top views of an adhesive applicator article 1600. The adhesive applicator article 1600 includes a backing 1630. In some examples, the backing 1630 is a PU backing. For example, the backing 1630 can be a 1 mil PU backing. The adhesive applicator article 1600 can include an adhesive layer 1620. In some examples, the adhesive layer 1620 is a double-sided adhesive that can adhere to the backing 1630 and the stack-up 1660. The stack-up 1660 can include an adhesive layer, a double-sided adhesive layer, and a 1 mil PU backing. The stack-up can be positioned on a liner 1610. In some embodiments, the liner 1610 is an FS liner. The liner 1610 and / or the border 1612 can be removed by a user to expose the stack-up 1660 to the user's skin. The liner can be coupled to and / or otherwise positioned at the border 1612. The border 1612 can provide not only a structure to the adhesive applicator article 1600 but also a guide for the user. The adhesive applicator article 1600 can further include a pull tab 1630 to facilitate removal of the border 1612. For example, the pull tab 1613 can facilitate removal of the border 1610. After removing the border 1610 using the pull tab 1613, the user can remove the liner 1610. The liner 1610 can facilitate the storage and / or shelf life of the ink composition.

[0217] FIG. 16B shows an exploded view of the adhesive applicator article 1600. The exploded view shows examples of the different elements of the adhesive applicator article 1600. In this case, the adhesive applicator article 1600 includes a backing (e.g., 1 mil PU backing) for bonding to the adhesive layer 1620 (e.g., a double-sided adhesive layer 1620) for bonding to the stack-up 1660. The stack-up 1660 can be bonded to the liner 1610 (e.g., an FS liner), and this can be removed to expose the stack-up 1660 to the user's skin. The border 1612 provides structure to the adhesive applicator article 1600 and can facilitate positioning and adhesion to the user's skin and / or handling and positioning on the user's skin.

[0218] FIG. 16C includes design examples including measurement examples. Although specific numbers are shown in FIG. 16, the embodiments are not so limited. A plurality of different dimensions are considered, and there may be more or fewer dimensions than those shown in FIG. 16. As referred to herein, the occlusion patch article can have larger dimensions in some embodiments compared to other embodiments discussed herein. For example, the occlusion patch article (e.g., the adhesive applicator article 1600) can have larger dimensions than the adhesive applicator article 1200 described in connection with FIG. 12.

[0219] The adhesive applicator article 1500 can be a combination of the adhesive applicator article 1200 and the adhesive applicator article 1300. Combining these two adhesive applicator articles can reduce the waste, performance issues, and user errors associated with positioning the article 1200 on top of the article 1300. Combining the two articles can reduce the possibility of wrinkles and user errors.

[0220] The embodiment shown in FIG. 16C includes an adhesive layer (e.g., adhesive layer 1620 in FIGS. 16A and 16B) including a boundary having a dimension of 3.0 inches (inch) (e.g., boundary portion 1612 in FIGS. 16A and 16B), a dimension of 2.7 inches, and a dimension of 2.4 inches, and a stack-up (e.g., stack-up 1660 in FIGS. 16A and 16B). The adhesive layer and / or the stack-up can include a design including an ink composition (e.g., ink composition 60 as described above in connection with FIG. 1). The boundary portion can have a radius of curvature (R) R = 0.3 inches, the adhesive layer can have a radius of curvature R = 0.2 inches, and the stack-up can have a radius of curvature R = 0.2 inches.

[0221] FIGS. 17A, 17B, and 17C are perspective views of an adhesive applicator article 1700 according to an embodiment of the present disclosure. FIG. 17A is a top view of the front and back of the adhesive applicator article 1700, FIG. 17B is an exploded view of the adhesive applicator article 1700, and FIG. 17C is an example of the dimensions of the adhesive applicator article 1700. An exemplary adhesive applicator 1700 can be an example of a closed patch article (e.g., closed patch article 1300 described in connection with FIG. 13) in which a stack-up 1760 is embedded.

[0222] Figure 17A shows a front and back top view of an adhesive applicator article 1700. The adhesive applicator article 1700 includes a backing 1730. In some examples, the backing 1730 is a PU backing. For example, the backing 1730 can be a 1-mil PU backing. The adhesive applicator article 1700 can include an adhesive layer 1720. In some examples, the adhesive layer 1720 is a double-sided adhesive that can adhere to the backing 1730 and the stack-up 1760. The stack-up 1760 can include an adhesive layer, a double-sided adhesive layer, and a 1-mil PU backing. The stack-up can be positioned on a liner 1710. In some embodiments, the liner 1710 is an FS liner. The liner 1710 and / or the border 1712 can be removed by the user to expose the stack-up 1760 to the user's skin. The liner can be coupled to and / or otherwise positioned at the border 1712. The border 1712 can provide not only a structure to the adhesive applicator article 1700 but also a guide for the user. The adhesive applicator article 1700 can further include a pull tab 1730 to facilitate removal of the border 1712. For example, the pull tab 1713 can facilitate removal of the border 1710. After removing the border 1710 using the pull tab 1713, the user can remove the liner 1710. The liner 1710 can facilitate the storage and / or shelf life of the ink composition.

[0223] Figure 17B shows an exploded view of the adhesive applicator article 1700. The exploded view shows examples of different elements of the adhesive applicator article 1700. In this case, the adhesive applicator article 1700 includes a backing (e.g., 1 mil PU backing) for bonding to the adhesive layer 1720 (e.g., a double-sided adhesive layer 1720) for bonding to the stack-up 1760. The stack-up 1760 can be bonded to the liner 1710 (e.g., an FS liner), which can be removed to expose the stack-up 1760 to the user's skin. The border 1712 provides structure to the adhesive applicator article 1700 and can facilitate positioning and adhesion to the user's skin and / or handling and positioning on the user's skin.

[0224] Figure 17C includes design examples including measurement examples. Although specific numbers are shown in Figure 17, the embodiments are not so limited. A plurality of different dimensions are considered, and there may be more or fewer dimensions than those shown in Figure 17. As mentioned herein, the occlusion patch article can have larger dimensions in some embodiments compared to other embodiments discussed herein. For example, the occlusion patch article (e.g., the adhesive applicator article 1700) can have larger dimensions than the adhesive applicator article 1200 described in connection with Figure 12.

[0225] The adhesive applicator article 1700 can be a combination of the adhesive applicator article 1200 and the adhesive applicator article 1300. Combining these two adhesive applicator articles can reduce waste, performance issues, and user errors associated with positioning the article 1200 on top of the article 1300. Combining the two articles can reduce the possibility of wrinkles and user errors.

[0226] The embodiment shown in FIG. 17C includes an adhesive layer (e.g., adhesive layer 1720 in FIGS. 17A and 17B) including a boundary having a dimension of 4.0 inches (inch) (e.g., boundary portion 1712 in FIGS. 17A and 17B), a dimension of 3.7 inches, and a dimension of 3.3 inches, and a stack-up (e.g., stack-up 1760 in FIGS. 17A and 17B). The adhesive layer and / or the stack-up can include a design including an ink composition (e.g., ink composition 60 as described above in connection with FIG. 1). The boundary portion can have a radius of curvature (R) R = 0.4 inches, the adhesive layer can have a radius of curvature R = 0.2 inches, and the stack-up can have a radius of curvature R = 0.2 inches.

[0227] FIGS. 18A, 18B, and 18C are perspective views of an adhesive applicator article 1800 according to an embodiment of the present disclosure. FIG. 18A is a top view of the front and back of the adhesive applicator article 1800, FIG. 18B is an exploded view of the adhesive applicator article 1800, and FIG. 18C is an example of the dimensions of the adhesive applicator article 1800. An exemplary adhesive applicator 1800 can be an example of a closed patch article (e.g., closed patch article 1300 described in connection with FIG. 13) in which a stack-up 1860 is embedded.

[0228] Figure 18A shows a front and back top view of an adhesive applicator article 1800. The adhesive applicator article 1800 includes a backing 1830. In some examples, the backing 1830 is a PU backing. For example, the backing 1830 can be a 1-mil PU backing. The adhesive applicator article 1800 can include an adhesive layer 1820. In some examples, the adhesive layer 1820 is a double-sided adhesive that can adhere to the backing 1830 and the stack-up 1860. The stack-up 1860 can include an adhesive layer, a double-sided adhesive layer, and a 1-mil PU backing. The stack-up can be positioned on a liner 1810. In some embodiments, the liner 1810 is an FS liner. The liner 1810 and / or the border 1812 can be removed by the user to expose the stack-up 1860 to the user's skin. The liner can be coupled to and / or otherwise positioned at the border 1812. The border 1812 can provide not only a structure to the adhesive applicator article 1800 but also a guide for the user. The adhesive applicator article 1800 can further include a pull tab 1830 to facilitate removal of the liner 1820. For example, the pull tab 1813 can facilitate removal of the border 1810. After removing the border 1810 using the pull tab 1813, the user can remove the liner 1810. The liner 1810 can facilitate the storage and / or shelf life of the ink composition.

[0229] FIG. 18B shows an exploded view of the adhesive applicator article 1800. The exploded view shows examples of the different elements of the adhesive applicator article 1800. In this case, the adhesive applicator article 1800 includes a backing (e.g., 1 mil PU backing) for bonding to the adhesive layer 1820 (e.g., a double-sided adhesive layer 1820) for bonding to the stack-up 1860. The stack-up 1860 can be bonded to a liner 1810 (e.g., an FS liner), and this can be removed to expose the stack-up 1860 to the user's skin. The border 1812 provides structure to the adhesive applicator article 1800 and can facilitate positioning and adhesion to the user's skin, and / or handling and positioning on the user's skin.

[0230] FIG. 18C includes design examples including measurement examples. Although specific numbers are shown in FIG. 18, the embodiments are not so limited. A plurality of different dimensions are considered, and there may be more or fewer dimensions than those shown in FIG. 18. As mentioned herein, the occlusive patch article can have larger dimensions in some embodiments compared to other embodiments discussed herein. For example, the occlusive patch article (e.g., the adhesive applicator article 1800) can have larger dimensions than the adhesive applicator article 1200 described in connection with FIG. 12.

[0231] The adhesive applicator article 1800 can be a combination of the adhesive applicator article 1200 and the adhesive applicator article 1300. Combining these two adhesive applicator articles can reduce the waste, performance issues, and user errors associated with positioning the article 1200 on top of the article 1300. Combining the two articles can reduce the possibility of wrinkles and user errors.

[0232] The embodiment shown in FIG. 18C includes a boundary (e.g., boundary portion 1812 of FIGS. 18A and 18B) having dimensions of 5 inches in length and 2.0 inches in width, dimensions of 4.75 inches in length and 1.75 inches in width, and dimensions of 4.4 inches in length and 1.4 inches in width, and an adhesive layer (e.g., adhesive layer 1820 of FIGS. 18A and 18B) including a stack-up (e.g., stack-up 1860 of FIGS. 18A and 18B). The adhesive layer and / or the stack-up can include a design including an ink composition (e.g., ink composition 60 as described above in connection with FIG. 1). The boundary portion can have a radius of curvature (R) R = 0.25 inches, the adhesive layer can have a radius of curvature R = 0.15 inches, and the stack-up can have a radius of curvature R = 0.15 inches.

[0233] FIG. 19 is another example of an adhesive applicator article 1900 according to another embodiment of the present disclosure. The adhesive applicator article 1900 can include an opening 1903, one or more portions of a backing 1958, a stack-up 1960, and a liner 1910. Although one opening 1903 is identified in FIG. 19, there can be more or fewer than one opening 1903. The stack-up 1960 can be similar to the stack-ups 1460, 1560, 1660, 1760, and 1860 described in connection with FIGS. 14, 15, 16, 17, and 18, respectively. The liner can be an FS liner that a user can selectively remove to expose the stack-up 1960 to the user's skin. The backing 1958 can be a removable backing. In some examples, the backing 1958 can be a removable paper backing that a user can remove during application of the adhesive applicator article 1900. FIG. 19 shows a label on a portion of the backing 1958, and as shown in FIG. 19, there are four portions to the backing 1958. Although four portions of the backing 1958 are shown in the example of the adhesive applicator article 1900, embodiments are not so limited and there can be more or fewer than four portions to the backing 1958.

[0234] The adhesive applicator article 1900 can include one or more apertures 1903 that can facilitate the rigidity of the adhesive applicator article 1900 during application of the adhesive applicator article 1900 to a portion of the user's body. For example, the adhesive applicator article 1900 can be of a design for a large design (e.g., an extra-large tattoo design). As shown in FIG. 19, the shape of the adhesive applicator article 1900 can be curved to provide a butterfly shape. The butterfly shape of the adhesive applicator article 1900 can conform to the contour of the body. The butterfly shape in combination with the apertures 1903 can prevent and / or reduce the lifting and peeling of the adhesive applicator article 1900 when an extra-large tattoo applicator is applied to any convex body surface (e.g., biceps, forearm, thigh, shoulder, etc.). Incorporating a structural layer such as a paper backing 1958 onto the adhesive applicator article 1900 can provide additional structural support to prevent wrinkles and / or facilitate a wrinkle-free application. The user can remove the FS liner 1910 and expose the adhesive layer included in the stack-up 1960 (e.g., in contact) to apply the design to the skin. The user can smooth the wrinkles by applying pressure to the paper backing 1958 and / or by smoothing the paper backing 1958. Once the user is satisfied with the application, the paper backing 1958 on one or more surfaces can be removed.

[0235] In another exemplary embodiment, the structural support can be further provided to the adhesive applicator article 1900 by cutting the FS liner on the adhesive side of the stack-up and / or by providing a border. These embodiments are described in connection with FIGS. 20A, 20B, and 21.

[0236] Figures 20A and 20B show perspective views of an exemplary adhesive applicator article 2000 according to another embodiment of the present disclosure. Figure 20A is an exploded view of the layers of the exemplary adhesive applicator article 2000 described in relation to Figure 20B. Figure 20B is a bottom view of the exemplary adhesive applicator article 2000.

[0237] Figure 20A shows an exploded view of the layers of the adhesive applicator article 2000. The adhesive applicator article 2000 includes one or more apertures 2003, a liner 2060a (e.g., a 1 mil PU liner), an adhesive layer (e.g., a double-sided adhesive layer) 2011, a stack-up 2060b, and an FS liner 2058.

[0238] Although one aperture 2003 is identified in Figures 20A and 20B, there may be more or fewer than one aperture 2003. The stack-ups 2060 of Figures 20A and 20B may be similar to the stack-ups 1460, 1560, 1660, 1760, and 1860 described in relation to Figures 14, 15, 16, 17, and 18, respectively. The adhesive layer 2011 of Figures 20A and 20B can provide structure and rigidity to the adhesive applicator article 2000.

[0239] The FS liner 2058 can be partially removed as described in relation to Figure 20A, and the adhesive layer 2011 can provide support to the adhesive applicator article 2000 during application and / or removal of the FS liner 2058. Figures 20A and 20B label a portion of the FS liner 2058, and as shown in Figures 20A and 20B, there are four portions of the backing 2058. Although four portions of the backing 2058 are shown in the example of the adhesive applicator article 2000, embodiments are not so limited and there may be more or fewer than four portions of the backing 2058.

[0240] Figure 20B shows layer 2060, an overlapping view of liner 2060a combined with stack-up 2060b described in relation to Figure 20A. Figure 20B further shows adhesive layer 2011 that can provide support during application. Figure 20B further shows FS liner 2058 in two sections 2058a and 2058b. A user can remove the central portion 2058b to expose the design printed on stack-up 2060. The user can position the design on the skin and smooth out wrinkles. Once the user is satisfied with the placement, the user can remove four portions of FS liner 2058a. During this application process, the double-sided adhesive layer 2011 can provide a strong structural boundary. Exemplary adhesive applicator article 2000 can include extending one or more of openings 2003 through FS liner 2058 such that FS liner 2058 can function as a structural boundary. The butterfly shape of adhesive applicator article 2000 can conform to the contour of the body.

[0241] The butterfly shape combined with opening 2003 extending through FS liner 2058 can prevent and / or reduce lifting and peeling of adhesive applicator article 2000 when an extra-large tattoo applicator is applied to any convex body surface (e.g., biceps, forearm, thigh, shoulder, etc.). Incorporation of structural layer 2011 can provide additional structural support to prevent wrinkles and / or facilitate wrinkle-free application.

[0242] FIG. 21 is another example of an adhesive applicator article 2100 according to another embodiment of the present disclosure. FIG. 21 is a bottom-up view similar to FIGS. 20A and 20B, except that there is no adhesive layer to provide a structural boundary. The adhesive applicator article 2100 includes an overlapping combination of a stack-up and an FS liner 2160. The adhesive applicator article 2100 can include one or more apertures 2103, one or more portions of a backing 2158a, and a central portion of a backing 2058b. Although one aperture 2103 is identified in FIG. 21, there may be more or fewer than one aperture 2103. The stack-up included in 2160 may be similar to the stack-ups 1460, 1560, 1660, 1760, and 1860 described in connection with FIGS. 14, 15, 16, 17, and 18, respectively.

[0243] The backing 2158 can be a removable backing. In some examples, the backing 2158 can be a removable paper backing and / or an FS liner that a user can remove during application of the adhesive applicator article 2100. FIG. 21 labels a portion of the backing 2158, and as shown in FIG. 21, there are four portions to the backing 2158. Although four portions of the backing 2158 are shown in an example of the adhesive applicator article 2100, embodiments are not so limited and there may be more or fewer than four portions of the backing 2158. An exemplary adhesive applicator article 2100 can include extending one or more of the apertures 2103 through an FS liner (not shown) on the adhesive side of the stack-up 2160 to provide structural support to the adhesive applicator article 2100.

[0244] The extension of one or more apertures 2103 through the FS liner on the adhesive side of the stack-up included in 2160, when applied to a convex surface, can provide support and better adhesion by lifting away from the user's skin and removing the backing 2058a and 2158b of the smaller portion of the article 2100. The butterfly shape of the adhesive applicator article 2100 can conform to the contour of the body. The combination of the aperture 2103 extending through the FS liner and the butterfly shape can prevent and / or reduce the lifting and peeling of the adhesive applicator article 2100 when an extra-large adhesive applicator is applied to any convex body surface (e.g., biceps, forearm, thigh, shoulder, etc.). Incorporating a structural layer such as a paper backing 2158 onto the adhesive applicator article 2100 can provide additional structural support to prevent wrinkling and / or facilitate a wrinkle-free application.

[0245] Figures 22A and 22B show another example of an adhesive applicator article 2200 according to another embodiment of the present disclosure. The example of the adhesive applicator article 2200 is an example of an adhesive applicator designed to provide a design arrangement on a convex portion of a user. For example, the adhesive applicator article 2200 can be applied to portions of a user's body such as the forearm, thigh, shoulder, biceps, etc.

[0246] Both Figures 22A and 22B include a plurality of panels that can include a design including an ink composition (e.g., ink composition 60 described in connection with FIG. 1). Panels 2270-1, 2270-2, 2270-3, 2270-4, 2270-5, and 2270-6 can be collectively referred to herein as panel 2270. Although six panels 2270 are shown in Figures 22A and 22B, embodiments are not so limited and embodiments can include more or fewer than six panels 2270.

[0247] Although not specifically labeled so as not to obscure the examples of the present disclosure, the adhesive applicator article 2200 can include any of the elements described in connection with FIGS. 1-21. For example, the adhesive applicator article 2200 can include, among other elements described herein, an adhesive layer, a backing, a liner, an ink composition, and a design. The adhesive applicator article 2200 can include an outer layer. The outer layer can include an adhesive layer, a backing, a liner, and the like. The outer layer can be on the opposite side of the portion of the adhesive applicator article 2200 that contacts the user's skin.

[0248] As described above, the adhesive applicator article 2200 can be used on a convex portion of a user's body, such as the forearm. The adhesive applicator article 2200 shown by FIGS. 22A and 22B can include one or more tabs 2271-1, 2271-2, and 2271-3, which may be referred to herein as tabs 2271. Although three tabs 2271 are shown in FIGS. 22A and 22B, embodiments are not so limited and embodiments can include more or fewer than three tabs 2271. The tabs 2271 are included to prevent and / or reduce peeling and to give the user a direction for application. For example, the user can apply the adhesive applicator article 2200 to the forearm and use the tabs 2271 to wrap the adhesive applicator article 2200 so that the tabs 2271 contact the portion 2274. The portion 2274 that the tabs 2271 can contact can include an outer layer. The tabs 2271 can adhere to the outer layer of the adhesive applicator article 2200 after being wrapped around the forearm. The tabs 2271 that contact the portion 2274 can hold the adhesive applicator article 2200 on the user's skin even during the user's movement.

[0249] Figure 22B shows exemplary dimensions (all dimensions are shown in inches). For example, the top of tab 2270 extends in a 23-degree arc from 7.5 inches to 13.0 inches (not including tab 2271). The bottom of tab 2270 extends to 8.25 when including tab 2271 and 4.75 when not including tab 2271. The height of the adhesive applicator article 2200 can be, for example, from 9.0 to 4.0 inches. Each panel 2270 includes a 4-degree arc with a 0.10 space that can function as a boundary. Figure 2B includes an enlarged perspective view of tab 2271-3. Tabs 2271-3 have a 0.10-inch boundary dimension, including a 0.50-inch width and 1.0-inch length for each tab, with a 0.30-inch space between the boundaries of each tab 2271. Specific numbers are listed and illustrated herein, but the embodiments are not so limited, and different sizes and configurations of the adhesive applicator article 2200 are contemplated to accommodate different-sized users.

[0250] Figures 23A and 23B show another example of an adhesive applicator article 2300 according to another embodiment of the present disclosure. The example of the adhesive applicator article 2300 is an example of an adhesive applicator designed to provide a design placement on convex and / or movable parts of a user. For example, the adhesive applicator article 2300 can be applied to such parts as a user's hand, foot, wrist, and / or ankle.

[0251] Although not specifically labeled so as not to obscure the examples of the present disclosure, the adhesive applicator article 2300 can include any of the elements described in relation to FIGS. 1-22. For example, the adhesive applicator article 2300 can include, among other elements described herein, an adhesive layer, a backing, a liner, an ink composition, and a design. The adhesive applicator article 2300 can include an outer layer. The outer layer can include an adhesive layer, a backing, a liner, and the like. The outer layer can be on the opposite side of the portion of the adhesive applicator article 2300 that contacts the user's skin.

[0252] Both FIGS. 23A and 23B include a first portion 2378 having a left side 2375 (e.g., a first side) and a right side 2376 (e.g., a second side), and a second portion 2379. The first portion 2378 and / or the second portion 2379 can include an ink composition (e.g., the ink composition 60 described in connection with FIG. 1). The left side 2375 and the right side 2376 are included to prevent and / or reduce peeling and to give the user a direction of application. For example, the user can apply the adhesive applicator article 2300 to the hand and / or wrist and use the left side 2375 and the right side 2376 to wrap the adhesive applicator article 2300 such that the left side 2375 contacts the right side 2376. The left side 2375 and the right side 2376 can adhere to each other's outer layers after being wrapped around the wrist. The left side 2375 and the right side 2376 can hold the adhesive applicator article 2300 on the user's skin even during the user's movement. Using these methods, the second portion 2379 can be positioned to provide a design on the upper part of the user's hand, and the first portion 2378 can be positioned to provide a design on the user's wrist.

[0253] FIG. 23B shows exemplary dimensions (all dimensions are shown in inches). For example, from the left side 2375 to the right side 2376, the first portion 2378 can be 6.19 inches and 6.20 inches including the curved portion. The widths of the left side 2375 and the right side 2376 can be 1.50 inches, and the distance from the left side 2375 and the right side 2376 to the second portion 2376 can be 2.10 inches. The flat portion of the second portion 2379 can be 1.32. On the other hand, the curved portion is R = 0.83 inches. The ends of the second portion 2379 can include R = 1.00 inches with a flat portion of 0.80 in between. The distance from the top of the first portion 2378 to the bottom of the second portion 2379 can be 4.50 inches. Although specific numbers are listed and illustrated herein, the embodiments are not so limited, and different sizes and configurations of the adhesive applicator article 2300 are contemplated to accommodate different sizes of users.

[0254] This specification also provides a skin priming composition comprising one or more volatile solvents, one or more amines, and one or more humectants.

[0255] In some embodiments, the one or more volatile solvents are present in the skin priming composition in an amount of about 60% to about 98% w / w of the composition. For example, about 60% to about 70%, about 60% to about 75%, about 60% to about 80%, about 60% to about 85%, about 60% to about 90%, about 60% to about 95%, about 95% to about 98%, about 90% to about 98%, about 85% to about 98%, about 80% to about 98%, about 75% to about 98%, or about 70% to about 98% w / w. In some embodiments, the one or more volatile solvents are present in the skin priming composition in an amount of about 80% to about 90%, about 85% to about 95%, about 85% to about 90%, or about 90% to about 95% w / w. In some embodiments, the one or more volatile solvents are present in the skin priming composition in an amount of about 80%, about 81%, about 82%, about 83%, about 84%, about 85%, about 86%, about 87%, about 88%, about 89%, about 90%, about 91%, about 92%, about 93%, about 94%, about 95%, about 96%, about 97%, or about 98% w / w.

[0256] In some embodiments, non-limiting examples of the one or more volatile solvents in the skin priming composition include water, methanol, ethanol, and isopropanol.

[0257] As used herein, "amine" describes a compound having a functional group containing a basic nitrogen atom with a lone pair of electrons. For example, an amine includes derivatives of ammonia (NH3) in which one or more hydrogen atoms are replaced with substituents. Non-limiting examples of amines include amino acids, panthenol, triethanolamine, and other compounds including primary, secondary, or tertiary amines. As used herein, the term "amino acid" refers to natural and non-natural L- and D-amino acids, peptidomimetic amino acids, and non-standard amino acids that are not made by standard mechanisms or are only found in proteins as post-translational modifications or metabolic intermediates. Exemplary amino acids include, but are not limited to, arginine, alanine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, δ-aminolevulinic acid, 4-aminobenzoic acid, and γ-aminobutyric acid. In some embodiments, the amino acid is the L-isomer. In some embodiments, the amino acid is the D-isomer. In some embodiments, the amino acid is an α-amino acid. In some embodiments, the amino acid is a β-, γ-, or δ-amino acid. For example, β-amino acids can be β-alanine, β-leucine, β-lysine, β-arginine, β-glutamic acid, β-β-glutamine, β-phenylalanine, and β-tyrosine.

[0258] In some embodiments, one or more amines are present in an amount of from about 0.5% to about 2%. For example, from about 0.5% to about 0.75%, from about 0.5% to about 1%, from about 0.5% to about 1.25%, from about 0.5% to about 1.5%, from about 0.5% to about 1.75%, from about 1.75% to about 2%, from about 1.5% to about 2%, from about 1.25% to about 2%, from about 1% to about 2%, or from about 0.75% to about 2% w / w of the composition. In some embodiments, one or more amines are present in an amount of from about 0.5% to about 0.6%, from about 0.55% to about 0.65%, from about 0.6% to about 0.7%, from about 0.65% to about 0.75%, from about 0.7% to about 0.8%, from about 0.75% to about 0.85%, from about 0.8% to about 0.9%, from about 0.85% to about 0.95%, from about 0.9% to about 1%, from about 0.95% to about 1.05%, from about 1% to about 1.1%, from about 1.05% to about 1.15%, from about 1.1% to about 1.2%, from about 1.15% to about 1.25%, from about 1.2% to about 1.3%, from about 1.25% to about 1.35%, from about 1.3% to about 1.4%, from about 1.35% to about 1.45%, from about 1.4% to about 1.6%, from about 1.5% to about 1.7%, from about 1.6% to about 1.8%, or from about 1.7% to about 1.9% w / w of the composition. For example, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.72%, about 0.74%, about 0.76%, about 0.78%, about 0.8%, about 0.81%, about 0.82%, about 0.83%, about 0.84%, about 0.85%, about 0.86%, about 0.87%, about 0.88%, about 0.89%, about 0.9%, about 0.91%, about 0.92%, about 0.93%, about 0.94%, about 0.96%, about 0.98%, about 1%, about 1.05%, about 1.1%, about 1.15%, about 1.2%, about 1.25%, about 1.3%, about 1.35%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w of the composition.

[0259] In some embodiments, one or more amines are selected from the group consisting of amino acids, panthenol, triethanolamine, and other compounds having a primary, secondary, or tertiary amine.

[0260] In some embodiments, one or more amines are one or more amino acids. In some embodiments, one or more amines include L-arginine. In some embodiments, one or more amines are L-arginine. In some embodiments, L-arginine is present in an amount of about 0.5% to about 2%. For example, about 0.5% to about 0.75%, about 0.5% to about 1%, about 0.5% to about 1.25%, about 0.5% to about 1.5%, about 0.5% to about 1.75%, about 1.75% to about 2%, about 1.5% to about 2%, about 1.25% to about 2%, about 1% to about 2%, or about 0.75% to about 2% w / w of the composition. In some embodiments, L-arginine is about 0.5% to about 0.6%, about 0.55% to about 0.65%, about 0.6% to about 0.7%, about 0.65% to about 0.75%, about 0.7% to about 0.8%, about 0.75% to about 0.85%, about 0.8% to about 0.9%, about 0.85% to about 0.95%, about 0.9% to about 1%, about 0.95% to about 1.05%, about 1% to about 1.1%, about 1.05% to about 1.15%, about 1.1% to about 1.2%, about 1.15% to about 1.25%, about 1.2% to about 1.3%, about 1.25% to about 1.35%, about 1.3% to about 1.4%, about 1.35% to about 1.45%, about 1.4% to about 1.6%, about 1.5% to about 1.7%, about 1.6% to about 1.8%, or about 1.7% to about 1.9% w / w of the composition. For example, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.72%, about 0.74%, about 0.76%, about 0.78%, about 0.8%, about 0.81%, about 0.82%, about 0.83%, about 0.84%, about 0.85%, about 0.86%, about 0.87%, about 0.88%, about 0.89%, about 0.9%, about 0.91%, about 0.92%, about 0.93%, about 0.94%, about 0.96%, about 0.98%, about 1%, about 1.05%, about 1.1%, about 1.15%, about 1.2%, about 1.25%, about 1.3%, about 1.35%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w of the composition.

[0261] As used herein, "humectant" refers to a substance that attracts water. For example, a humectant can attract water and provide moisture to the skin. Non-limiting examples of humectants include glycerin, propylene glycol, polyethylene glycol, sugars, hexylene glycol, butylene glycol, aloe vera gel, alpha-hydroxy acids such as lactic acid, glyceryl triacetate, lithium chloride, sorbitol, xylitol, maltitol, hyaluronic acid, allantoin, urea, tremella extract, dicyandiamide, sodium lactate, sodium L-pyroglutamate urea, and pyrrolidone carboxylic acid.

[0262] In some embodiments, one or more humectants are present in an amount of about 1% to about 10% w / w of the composition. For example, about 1% to about 2%, about 1% to about 3%, about 1% to about 4%, about 1% to about 5%, about 1% to about 6%, about 1% to about 7%, about 1% to about 8%, about 1% to about 9%, about 9% to about 10%, about 8% to about 10%, about 7% to about 10%, about 6% to about 10%, about 5% to about 10%, about 4% to about 10%, about 3% to about 10%, about 2% to about 10% w / w of the composition. In some embodiments, one or more humectants are present in an amount of about 1% to about 3%, about 2% to about 4%, about 3% to about 5%, about 4% to about 6%, about 5% to about 7%, about 6% to about 8%, or about 7% to about 9% w / w of the composition. For example, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, or about 10% w / w of the composition.

[0263] In some embodiments, non-limiting examples of one or more humectants include glycerin, propylene glycol, polyethylene glycol, sugars, hexylene glycol, butylene glycol, aloe vera gel, alpha-hydroxy acids (such as lactic acid, glyceryl triacetate, lithium chloride, sorbitol, xylitol, maltitol, hyaluronic acid, allantoin, urea, tremella extract, dicyandiamide, sodium lactate, and sodium L-pyroglutamate).

[0264] In some embodiments, the one or more humectants include glycerin. In some embodiments, the one or more humectants are glycerin. In some embodiments, glycerin is present in an amount of about 1% to about 10% w / w of the composition. For example, about 1% to about 2%, about 1% to about 3%, about 1% to about 4%, about 1% to about 5%, about 1% to about 6%, about 1% to about 7%, about 1% to about 8%, about 1% to about 9%, about 9% to about 10%, about 8% to about 10%, about 7% to about 10%, about 6% to about 10%, about 5% to about 10%, about 4% to about 10%, about 3% to about 10%, about 2% to about 10% w / w of the composition. In some embodiments, glycerin is present in an amount of about 1% to about 3%, about 2% to about 4%, about 3% to about 5%, about 4% to about 6%, about 5% to about 7%, about 6% to about 8%, or about 7% to about 9% w / w of the composition. For example, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, or about 10% w / w of the composition.

[0265] In some embodiments, the skin priming composition can further comprise one or more semi-volatile semi-permanent colorant solubilizers. In some embodiments, the one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 0.1% to about 10% w / w of the composition. For example, about 0.1% to about 9%, about 0.1% to about 8%, about 0.1% to about 7%, about 0.1% to about 6%, about 0.1% to about 5%, about 0.1% to about 4%, about 0.1% to about 3%, about 0.1% to about 2%, about 0.1% to about 1%, about 9% to about 10%, about 8% to about 10%, about 7% to about 10%, about 6% to about 10%, about 5% to about 10%, about 4% to about 10%, about 3% to about 10%, about 2% to about 10%, or about 1% to about 10% w / w of the composition. In some embodiments, the one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 0.5% to about 1%, about 0.5% to about 1.5%, about 1% to about 2%, about 1.5% to about 2.5%, about 2% to about 3%, or about 0.5% to about 3% w / w of the composition. In some embodiments, the one or more semi-volatile semi-permanent colorant solubilizers are present in an amount of about 0.25%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, or about 10% w / w of the composition.

[0266] In some embodiments, the one or more semi-volatile semi-permanent colorant solubilizers are selected from the group consisting of polyethylene glycol, alkyl glycol, and alkylene glycol ether.

[0267] In some embodiments, the semi-volatile semi-permanent colorant solubilizer comprises diethylene glycol monoethyl ether. In some embodiments, the semi-volatile semi-permanent colorant solubilizer is diethylene glycol monoethyl ether.

[0268] In some embodiments, the skin priming composition can further comprise one or more skin penetration enhancers. In some embodiments, the one or more skin penetration enhancers are present in an amount of about 5% to about 10% w / w of the composition. For example, about 5% to about 6%, about 5% to about 7%, about 5% to about 8%, about 5% to about 9%, about 9% to about 10%, about 8% to about 10%, about 7% to about 10%, or about 6% to about 10% w / w of the composition. In some embodiments, the one or more skin penetration enhancers are present in an amount of about 5% to about 7%, about 6% to about 8%, or about 7% to about 9% w / w of the composition. For example, about 5%, about 5.25%, about 5.5%, about 5.75%, about 6%, about 6.25%, about 6.5%, about 6.75%, about 7%, about 7.25%, about 7.5%, about 7.75%, about 8%, about 8.25%, about 8.5%, about 8.75%, about 9%, about 9.25%, about 9.5%, about 9.75%, or about 10% w / w of the composition.

[0269] In some embodiments, non-limiting examples of one or more skin penetration enhancers can include alcohols, amides, esters, ether alcohols, fatty acids, glycols, pyrrolidones, sulfoxides, surfactants, and terpenes. In some embodiments, non-limiting examples of one or more skin penetration enhancers can include ethanol, isopropanol, decanol, hexanol, lauryl alcohol, myristyl alcohol, octanol, octyldodecanol, oleyl alcohol, azone, ethyl acetate, octyl salicylate, padimate O, ethyl oleate, glyceryl monooleate, glyceryl monocaprylate, glyceryl tricaprylate, isopropyl myristate, isopropyl palmitate, propylene glycol monolaurate, propylene glycol monocaprylate, diethylene glycol monoethyl ether (TRANSCUTOL®), lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, stearic acid, isostearic acid, dipropylene glycol, propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, n-methyl-2-pyrrolidone, 2-pyrrolidone, decyl methyl sulfoxide, dimethyl sulfoxide, sodium lauryl sulfate, alkyl dimethyl benzyl ammonium halide, alkyl trimethyl ammonium halide, alkyl pyridinium halide, brij 36t, polyethylene glycol sorbitan monooleate (e.g., TWEEN® 80), eugenol, D-limonene, menthol, menthone, farnesol, and neridol.

[0270] In some embodiments, the skin priming composition can further include one or more preservatives. In some embodiments, the one or more preservatives are present in an amount of about 0.05% to about 5% w / w of the composition. For example, about 0.05% to about 0.1%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.05% to about 2%, about 0.05% to about 3%, about 0.05% to about 4%, about 4% to about 5%, about 3% to about 5%, about 2% to about 5%, about 1% to about 5%, about 0.5% to about 5%, or about 0.1% to about 5% w / w. In some embodiments, the one or more preservatives are present in an amount of 0.1% to about 2%, 0.5% to about 2.5%, about 1% to about 3%, about 1.5% to about 3.5%, about 2% to about 4%, about 2.5% to about 4.5% w / w of the composition. In some embodiments, the one or more preservatives are present in an amount of about 0.5% to about 2% w / w of the composition. In some embodiments, the one or more preservatives are present in an amount of about 0.5% to about 1.5%, about 0.5% to about 1.0%, about 0.05% to about 0.5%, about 0.05% to about 0.1%, about 1.5% to about 2%, about 1% to about 2%, about 0.5% to about 2%, or about 0.8% to about 2%, or about 0.1% to about 0.9% w / w. For example, about 0.05% to about 0.4%, about 0.05% to about 0.2%, about 0.2% to about 0.5%, about 0.15% to about 0.25%, or about 0.1% to about 0.3% w / w. In some embodiments, the one or more preservatives are present in an amount of about 0.01%, about 0.05%, about 0.1%, about 0.12%, about 0.14%, about 0.15%, about 0.16%, about 0.18%, about 0.2%, about 0.22% about 0.25%, about 0.26%, about 0.28%, about 0.3%, about 0.32%, about 0.34%, about 0.35%, about 0.36%, about 0.38%, about 0.4%, about 0.45%, about 0.5%, about 0.6%, about 0.65%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w of the composition.

[0271] In some embodiments, one or more preservatives are ascorbic acid, ascorbate, palmitate, citric acid, benzoate, benzoic acid, propionate, propionic acid, sorbate, sorbic acid, salicylic acid, salicylate, hex-2,4-dienoic acid, hex-2,4-dienoate, formaldehyde, formaldehyde-releasing agents, formic acid and its salts, 3-acetyl-6-methylpyran-2,4-(3H)-dione and its salts, 3,3'-dibromo-4,4'-hexamethylenedioxydibenzamidine and its salts, thimerosal, phenylmercury salts, undec-10-enoic acid and its salts, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-5-pyrimidine, 5-bromo-5-nitro-1,3-dioxane, bronopol, 2,4-dichlorobenzyl alcohol, 1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea, chlorocresol, chloroxylenol, 5-chloro-2-(2,4-dichlorophenoxy)phenol, N,N”-methylenebis[N’-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea], polyaminopropylbiguanide, methenamine, quaternium-15, climbazole, DMDM hydantoin, benzyl alcohol, 1-hydroxy-4-methyl-6-(2,4,Selected from the group consisting of 4-(trimethylpentyl)-2-pyridone, piroctone olamine, bromochlorophene, o-cymen-5-ol, chlorophene, chloroacetamide, methylchloroisothiazolinone, methylisothiazolinone, phenoxyisopropanol, chlorhexidine, chlorhexidine diacetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, dimethyloxazolidine, behentrimonium chloride, cetrimonium bromide, cetrimonium chloride, laurotrimonium bromide, laurotrimonium chloride, stearotrimonium bromide, stearotrimonium chloride, diazolidinyl urea, hexamidine, hexamidine diisethionate, hexamidine parabens, glutaral, 7-ethylbicyclooxazolidine, chlorphenesin, sodium hydroxymethylglycinate, silver chloride, benzethonium chloride, benzalkonium chloride, benzalkonium bromide, benzalkonium saccharinate, benzyl hemiformal, iodopropynyl butylcarbamate, biphenyl-2-ol and its salts, zinc pyrithione, erythorbate, nitrous acid, ethylenediaminetetraacetic acid (EDTA), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), capric acid, dilauryl thiodipropionate, erythorbic acid, guaiac resin, methylparabens, sulfite, bisulfite, metabisulfite, propyl gallate, propylparabens, stannous chloride, sulfur dioxide, thiodipropionic acid, isothiazoline, parabens, phenoxyethanol, ethylhexylglycerin, glycol, and tocopherol.,

[0272] In some embodiments, one or more preservatives are phenoxyethanol and ethylhexylglycerin (e.g., Euxyl® PE9010). In some embodiments, phenoxyethanol and ethylhexylglycerin are present in the composition in a ratio of 9:1 phenoxyethanol:ethylhexylglycerin.

[0273] In some embodiments, phenoxyethanol and ethylhexylglycerin are present in the composition in an amount of about 0.05% to about 5% w / w. For example, about 0.05% to about 0.1%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.05% to about 2%, about 0.05% to about 3%, about 0.05% to about 4%, about 4% to about 5%, about 3% to about 5%, about 2% to about 5%, about 1% to about 5%, about 0.5% to about 5%, or about 0.1% to about 5% w / w. In some embodiments, phenoxyethanol and ethylhexylglycerin are present in the composition in an amount of 0.1% to about 2%, 0.5% to about 2.5%, about 1% to about 3%, about 1.5% to about 3.5%, about 2% to about 4%, about 2.5% to about 4.5% w / w. In some embodiments of the ink compositions described herein, phenoxyethanol and ethylhexylglycerin are present in the composition in an amount of about 0.5% to about 2% w / w. In some embodiments of the ink compositions described herein, phenoxyethanol and ethylhexylglycerin are present in the composition in an amount of about 0.5% to about 1.5%, about 0.5% to about 1.0%, about 0.05% to about 0.5%, about 0.05% to about 0.1%, about 1.5% to about 2%, about 1% to about 2%, about 0.5% to about 2%, or about 0.8% to about 2%, or about 0.1% to about 0.9% w / w. For example, about 0.05% to about 0.4%, about 0.05% to about 0.2%, about 0.2% to about 0.5%, about 0.15% to about 0.25%, or about 0.1% to about 0.3% w / w. In some embodiments of the ink compositions described herein, phenoxyethanol and ethylhexylglycerin are present in the composition in an amount of about 0.01%, about 0.05%, about 0.1%, about 0.12%, about 0.14%, about 0.15%, about 0.16%, about 0.18%, about 0.2%, about 0.22, about 0.25%, about 0.26%, about 0.28%, about 0.3%, about 0.32%, about 0.34%, about 0.35%, about 0.36%, about 0.38%, about 0.4%, about 0.45%, about 0.5%, about 0.6%, about 0.65%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w.

[0274] In some embodiments, the skin priming composition comprises one or more volatile solvents present in an amount of about 91% to about 97% w / w of the composition, one or more amines present in an amount of about 0.8% to about 1.2% w / w of the composition, and one or more humectants present in an amount of about 1% to about 10% w / w of the composition . In some embodiments, the composition further comprises one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition.

[0275] In some embodiments, the skin priming composition comprises one or more volatile solvents present in an amount of about 93% w / w of the composition, one or more amines present in an amount of about 1% w / w of the composition, and one or more humectants present in an amount of about 5% w / w of the composition . In some embodiments, the composition further comprises one or more preservatives present in an amount of about 1% w / w of the composition.

[0276] In some embodiments, the skin priming composition comprises one or more volatile solvents present in an amount of about 91% to about 97% w / w of the composition, wherein the one or more volatile solvents are water, one or more amines present in an amount of about 0.8% to about 1.2% w / w of the composition, wherein the one or more amines are L-arginine, and one or more humectants present in an amount of about 1% to about 10% w / w of the composition, wherein the one or more humectants are glycerin . In some embodiments, the composition further comprises one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition, and the one or more preservatives are phenoxyethanol and ethylhexylglycerin (e.g., phenoxyethanol and ethylhexylglycerin in a ratio of about 9:1).

[0277] In some embodiments, the skin priming composition comprises One or more volatile solvents present in an amount of about 91% to about 97% w / w of the composition, the one or more volatile solvents being water, and One or more amines present in an amount of about 0.9% to about 1.1% w / w of the composition, the one or more amines being L-arginine, and One or more humectants present in an amount of about 1% to about 10% w / w of the composition, the one or more humectants being glycerin and. In some embodiments, the composition further comprises one or more preservatives present in an amount of about 0.1% to about 2% w / w of the composition, and the one or more preservatives are phenoxyethanol and ethylhexylglycerin (for example, phenoxyethanol and ethylhexylglycerin in a ratio of about 9:1).

[0278] In some embodiments, the skin priming composition One or more volatile solvents present in an amount of about 93% w / w of the composition, the one or more volatile solvents being water, and One or more amines present in an amount of about 1% w / w of the composition, the one or more amines being L-arginine, and One or more humectants present in an amount of about 5% w / w of the composition, the one or more humectants being glycerin and. In some embodiments, the composition further comprises one or more preservatives present in an amount of about 1% w / w of the composition, and the one or more preservatives are phenoxyethanol and ethylhexylglycerin (for example, phenoxyethanol and ethylhexylglycerin in a ratio of about 9:1).

[0279] In some embodiments, the skin priming composition One or more volatile solvents present in an amount of about 91% to about 97% w / w of the composition, and One or more amines present in an amount of about 0.8% to about 0.9% w / w of the composition, and One or more humectants present in an amount of about 1% to about 10% w / w of the composition and.

[0280] In some embodiments, the skin priming composition is one or more volatile solvents present in an amount of about 91% to about 97% w / w of the composition, the one or more volatile solvents being water, and one or more amines present in an amount of about 0.8% to about 0.9% w / w of the composition, the one or more amines being L-arginine, and one or more humectants present in an amount of about 1% to about 10% w / w of the composition, the one or more humectants being glycerin and comprises.

[0281] In some embodiments, the skin priming composition is one or more volatile solvents present in an amount of about 94% w / w of the composition, the one or more volatile solvents being water, and one or more amines present in an amount of about 0.85% w / w of the composition, the one or more amines being L-arginine, and one or more humectants present in an amount of about 5% w / w of the composition, the one or more humectants being glycerin and comprises.

[0282] In some embodiments, the skin priming composition can be configured to have a pH of about 4 to about 7. For example, about 4 to about 5, about 4.5 to about 5.5, about 5 to about 6, about 5.5 to about 6.5, or about 6 to about 7. In some embodiments, the skin priming composition can be configured to have a pH of about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, or about 7.

[0283] In some embodiments, the skin priming composition is adjusted to a pH of about 4 to about 7. For example, about 4 to about 5, about 4.5 to about 5.5, about 5 to about 6, about 5.5 to about 6.5, or about 6 to about 7. In some embodiments, the skin priming composition is adjusted to a pH of about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, or about 7.

[0284] In some embodiments, the skin priming composition can have a pH of from about 4 to about 7. For example, from about 4 to about 5, from about 4.5 to about 5.5, from about 5 to about 6, from about 5.5 to about 6.5, or from about 6 to about 7. In some embodiments, the skin priming composition can have a pH of about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, or about 7.

[0285] Also provided herein are skin priming articles moistened with any of the skin priming compositions of the above embodiments. In some embodiments, the moistened article can be a towel, pad, woven fabric, non-woven fabric, etc. In some embodiments, the moistened article can be housed in a sealed package to maintain the moist nature of the article.

[0286] Also provided herein is an aftercare composition comprising one or more volatile solvents, one or more humectants, and one or more occlusives. The aftercare composition can be used, for example, to extend the duration of semi-permanent tattooing. For example, the aftercare compositions described herein may help slow the rate of skin shedding, or the excretion of dead skin surface cells. In some embodiments, the aftercare compositions described herein can help maintain the health of skin surface cells and slow the turnover, aging, and / or death of skin surface cells.

[0287] In some embodiments, one or more volatile solvents are present in the aftercare composition in an amount of about 20% to about 90% w / w of the composition. For example, about 20% to about 60%, about 50% to about 90%, about 20% to about 40%, about 30% to about 50%, about 40% to about 60%, about 50% to about 70%, about 60% to about 80%, or about 70% to about 90% w / w of the composition. In some embodiments, one or more volatile solvents are present in the aftercare composition in an amount of about 30% to about 35%, about 32% to about 37%, about 35% to about 40%, about 37% to about 42%, about 40% to about 50%, about 50% to about 60%, about 60% to about 65%, about 62% to about 67%, about 65% to about 70%, about 67% to about 72%, about 70% to about 75%, about 75% to about 80%, about 80% to about 85%, or about 85% to about 90% w / w of the composition. In some embodiments, one or more volatile solvents are present in the aftercare composition in an amount of about 20%, about 21%, about 22%, about 23%, about 24%, about 25%, about 25%, about 27%, about 28%, about 29%, about 30%, about 31%, about 32%, about 33%, about 34%, about 35%, about 36%, about 37%, about 38%, about 39%, about 40%, about 41%, about 42%, about 43%, about 44%, about 45%, about 46%, about 47%, about 48%, about 49%, about 50%, about 51%, about 52%, about 53%, about 54%, about 55%, about 56%, about 57%, about 58%, about 59%, about 60%, about 61%, about 62%, about 63%, about 64%, about 65%, about 66%, about 67%, about 68%, about 69%, about 70%, about 71%, about 72%, about 73%, about 74%, about 75%, about 76%, about 77% w / w, about 78%, about 79%, about 80%, about 81%, about 82%, about 83%, about 84%, about 85%, about 86%, about 87%, about 88%, about 89%, or about 90% of the composition.

[0288] In some embodiments, non-limiting examples of one or more volatile solvents in the skin priming composition include water, methanol, ethanol, and isopropanol.

[0289] In some embodiments, one or more humectants are present in an amount of about 5% to about 45% w / w of the composition. For example, about 5% to about 10%, about 5% to about 15%, about 5% to about 20%, about 5% to about 25%, about 5% to about 30%, about 5% to about 35%, about 5% to about 40%, about 40% to about 45%, about 35% to about 45%, about 30% to about 45%, about 25% to about 45%, about 20% to about 45%, about 15% to about 45%, or about 10% to about 40% w / w of the composition. In some embodiments, one or more humectants are present in an amount of about 5% to about 15%, about 10% to about 25%, about 15% to about 35%, about 20% to about 30%, about 25% to about 35%, or about 30% to about 40% w / w of the composition. For example, about 20%, about 21%, about 22%, about 23%, about 24%, about 25%, about 26%, about 27%, about 28%, about 29%, about 30%, about 31%, about 32%, about 33%, about 34%, or about 35% w / w of the composition.

[0290] In some embodiments, non-limiting examples of one or more humectants include glycerin, propylene glycol, polyethylene glycol, sugars, hexylene glycol, butylene glycol, aloe vera gel, alpha-hydroxy acids such as lactic acid, glyceryl triacetate, lithium chloride, sorbitol, xylitol, maltitol, hyaluronic acid, allantoin, urea, tremella extract, dicyandiamide, sodium lactate, sodium L-pyroglutamate, urea, and pyrrolidone carboxylic acid.

[0291] In some embodiments, the one or more humectants include glycerin. In some embodiments, the one or more humectants are glycerin. In some embodiments, glycerin is present in an amount of about 5% to about 45% w / w of the composition. For example, about 5% to about 10%, about 5% to about 15%, about 5% to about 20%, about 5% to about 25%, about 5% to about 30%, about 5% to about 35%, about 5% to about 40%, about 40% to about 45%, about 35% to about 45%, about 30% to about 45%, about 25% to about 45%, about 20% to about 45%, about 15% to about 45%, or about 10% to about 40% w / w of the composition. In some embodiments, glycerin is present in an amount of about 5% to about 15%, about 10% to about 25%, about 15% to about 35%, about 20% to about 30%, about 25% to about 35%, or about 30% to about 40% w / w of the composition. For example, about 20%, about 21%, about 22%, about 23%, about 24%, about 25%, about 26%, about 27%, about 28%, about 29%, about 30%, about 31%, about 32%, about 33%, about 34%, or about 35% w / w of the composition.

[0292] As used herein, "occlusive agent" refers to an agent that physically prevents or reduces water loss. For example, an occlusive agent can provide a barrier that prevents or reduces transepidermal water loss. Non-limiting examples of occlusive agents include film formers, silicones, waxes, oils, and petrolatum. For example, a film former can include vinyl pyrrolidone, acrylate, silsesquioxane, siloxane, vinyl alcohol, glycol, urethane, styrene, butadiene, peptide, or polysaccharide.

[0293] As used herein, "skin softener" refers to an agent that softens or soothes the skin by filling the spaces between skin flakes and creating a smooth skin surface. Non-limiting examples of skin softeners include alkyl alcohols, glycol alkyl ethers, short-chain hydrocarbons, and alkyl esters. Other non-limiting examples of skin softeners include collagen, colloidal oatmeal, elastin, glyceryl stearate, isopropyl palmitate, shea butter, and stearic acid. In some embodiments, at least one of the one or more skin softeners also functions as an occlusive agent (also referred to herein as an occlusive skin softener). For example, a combination of dimethicone, tricosiloxane, ceteareth-10, and laureth-4 (e.g., Dow Corning 7-3110 Volatile Fluid HIP Emulsion) is a skin softener having occlusive properties.

[0294] In some embodiments, one or more occluding agents are present in an amount of about 0.05% to about 2% w / w of the composition. For example, about 0.05% to about 0.2%, about 0.05% to about 0.3%, about 0.05% to about 0.4%, about 0.05% to about 0.5%, about 0.15% to about 0.45%, about 0.2% to about 0.4%, about 0.4% to about 0.5%, about 0.3% to about 0.5%, about 0.2% to about 0.5%, or about 0.1% to about 0.5% w / w of the composition. In some embodiments, one or more occluding agents are present in an amount of about 0.05% to about 0.1%, about 0.075% to about 0.125%, about 0.1% to about 0.15%, about 0.125% to about 0.175%, about 0.15% to about 0.2%, about 0.175% to about 0.225%, about 0.2% to about 0.25%, about 0.225% to about 0.275%, about 0.25% to about 0.3%, about 0.275% to about 0.325%, about 0.3% to about 0.35%, about 0.325% to about 0.375%, about 0.35% to about 0.4%, about 0.375% to about 0.425%, about 0.4% to about 0.45%, about 0.425% to about 0.475%, about 0.45% to about 0.5%, about 0.475% to about 0.525%, about 0.5% to about 0.55%, about 0.525% to about 0.575%, about 0.55% to about 0.6%, about 0.6% to about 0.7%, about 0.7% to about 0.8%, about 0.8% to about 0.9%, about 0.9% to about 1%, about 1% to about 1.2%, about 1.2% to about 1.4%, about 1.4% to about 1.6%, about 1.6% to about 1.8%, or about 1.8% to about 2% w / w of the composition. For example, about 0.05%, about 0.1%, about 0.15%, about 0.2%, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.75%, about 0.8%, about 0.85%, about 0.9%, about 0.95%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, about 2% w / w of the composition.

[0295] In some embodiments, one or more occlusive agents comprise an acrylate / C10-30 alkyl acrylate crosspolymer. In some embodiments, one or more occlusive agents are an acrylate / C10-30 alkyl acrylate crosspolymer. In some embodiments, the acrylate / C10-30 alkyl acrylate crosspolymer is present in an amount of about 0.05% to about 2% w / w of the composition. For example, about 0.05% to about 0.2%, about 0.05% to about 0.3%, about 0.05% to about 0.4%, about 0.05% to about 0.5%, about 0.15% to about 0.45%, about 0.2% to about 0.4%, about 0.4% to about 0.5%, about 0.3% to about 0.5%, about 0.2% to about 0.5%, or about 0.1% to about 0.5% w / w of the composition. In some embodiments, the acrylate / C10-30 alkyl acrylate crosspolymer is 0.05% to about 0.1%, about 0.075% to about 0.125%, about 0.1% to about 0.15%, about 0.125% to about 0.175%, about 0.15% to about 0.2%, about 0.175% to about 0.225%, about 0.2% to about 0.25%, about 0.225% to about 0.275%, about 0.25% to about 0.3%, about 0.275% to about 0.325%, about 0.3% to about 0.35%, about 0.325% to about 0.375%, about 0.35% to about 0.4%, about 0.375% to about 0.425%, about 0.4% to about 0.45%, about 0.425% to about 0.475%, about 0.45% to about 0.5%, about 0.475% to about 0.525%, about 0.5% to about 0.55%, about 0.525% to about 0.575%, about 0.55% to about 0.6%, about 0.6% to about 0.7%, about 0.7% to about 0.8%, about 0.8% to about 0.9%, about 0.9% to about 1%, about 1% to about 1.2%, about 1.2% to about 1.4%, about 1.4% to about 1.6%, about 1.6% to about 1.8%, or about 1.8% to about 2% w / w of the composition. For example, about 0.05%, about 0.1%, about 0.15%, about 0.2%, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.75%, about 0.8%, about 0.85%, about 0.9%, about 0.95%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, about 2% w / w of the composition.

[0296] In some embodiments, the composition further comprises a skin softening agent. In some embodiments, one or more skin softening agents are present in an amount of about 5% to about 55% w / w of the composition. For example, about 5% to about 10%, about 5% to about 15%, about 5% to about 20%, about 5% to about 25%, about 5% to about 30%, about 5% to about 35%, about 5% to about 40%, about 5% to about 45%, about 5% to about 50%, about 50% to about 55%, about 45% to about 55%, about 40% to about 55%, about 35% to about 5%, about 30% to about 55%, about 25% to about 55%, about 20% to about 55%, about 20% to about 55%, about 15% to about 55%, or about 10% to about 55% w / w of the composition. For example, about 10% to about 20%, about 15% to about 25%, about 20% to about 30%, about 25% to about 35%, about 25% to about 30%, about 30% to about 40%, about 30% to about 35%, about 35% to about 45%, about 35% to about 40%, or about 40% to about 50% w / w of the composition. In some embodiments, one or more skin softening agents are present in an amount of about 25%, about 26%, about 27%, about 28%, about 29%, about 30%, about 31%, about 32%, about 33%, about 34%, about 35%, about 36%, about 37%, about 38%, about 39%, about 40%, about 41%, about 42%, about 43%, about 44%, about 45%, about 46%, about 47%, about 48%, about 49%, or about 50% w / w of the composition.

[0297] In some embodiments, one or more skin softening agents are selected from the group consisting of alkyl alcohols, glycol alkyl ethers, short-chain hydrocarbons, and alkyl esters. In some embodiments, one or more skin softening agents are selected from the group consisting of collagen, colloidal oatmeal, elastin, glyceryl stearate, isopropyl palmitate, shea butter, and stearic acid. In some embodiments, at least one of the one or more skin softening agents also functions as an occlusive agent.

[0298] In some embodiments where at least one of the one or more skin softeners also functions as an occlusive agent, at least one skin softener that also functions as an occlusive agent is a combination of dimethicone, tricosiloxane, ceteth-10, and laureth-4 (e.g., Dow Corning 7-3110 volatile fluid HIP emulsion). In some embodiments, the combination of dimethicone, tricosiloxane, ceteth-10, and laureth-4 is present in an amount of about 5% to about 55% w / w of the composition. For example, about 5% to about 10%, about 5% to about 15%, about 5% to about 20%, about 5% to about 25%, about 5% to about 30%, about 5% to about 35%, about 5% to about 40%, about 5% to about 45%, about 5% to about 50%, about 50% to about 55%, about 45% to about 55%, about 40% to about 55%, about 35% to about 5%, about 30% to about 55%, about 25% to about 55%, about 20% to about 55%, about 20% to about 55%, about 15% to about 55%, or about 10% to about 55% w / w of the composition. For example, about 10% to about 20%, about 15% to about 25%, about 20% to about 30%, about 25% to about 35%, about 30% to about 40%, or about 35% to about 45% w / w of the composition. In some embodiments, the combination of dimethicone, tricosiloxane, ceteth-10, and laureth-4 is present in an amount of about 25%, about 26%, about 27%, about 28%, about 29%, about 30%, about 31%, about 32%, about 33%, about 34%, about 35%, about 36%, about 37%, about 38%, about 39%, about 40%, about 41%, about 42%, about 43%, about 44%, about 45%, about 46%, about 47%, about 48%, about 49%, or about 50% w / w of the composition.

[0299] In some embodiments, the aftercare composition described herein can further comprise one or more amines. In some embodiments, the one or more amines are present in an amount of about 0.01% to about 2% w / w of the composition. For example, about 0.01%, about 0.05%, about 0.01%, about 0.1%, about 0.01%, about 0.25%, about 0.01%, about 0.5%, about 0.01%, about 0.75%, about 0.01% to about 1%, about 0.01% to about 1.25%, about 0.01% to about 1.5%, about 0.01% to about 1.75%, about 0.01% to about 2%, about 1.75% to about 2%, about 1.5% to about 2%, about 1.25% to about 2%, about 1% to about 2%, about 0.75% to about 2%, about 0.5% to about 2%, about 0.25% to about 2%, about 0.1% to about 2%, about 0.05% to about 2% w / w. In some embodiments, the one or more amines are present in an amount of 0.25% to about 1.25%, about 0.2% to about 0.3%, about 0.25% to about 0.35%, about 0.3% to about 0.4%, about 0.35% to about 0.45%, about 0.4% to about 0.5%, about 0.45% to about 0.55%, about 0.5% to about 0.6%, about 0.55% to about 0.65%, about 0.6% to about 0.7%, about 0.65% to about 0.75%, about 0.7% to about 0.8%, about 0.75% to about 0.85%, about 0.8% to about 0.9%, about 0.85% to about 0.95%, about 0.9% to about 1%, about 0.95% to about 1.05%, about 1% to about 1.1%, about 1.05% to about 1.15%, about 1.1% to about 1.2%, about 1.15% to about 1.25%, about 1.2% to about 1.3%, about 1.25% to about 1.35%, about 1.3% to about 1.4%, about 1.35% to about 1.45%, about 1.4% to about 1.6%, about 1.5% to about 1.7%, about 1.6% to about 1.8%, or about 1.7% to about 1.9% w / w of the composition.For example, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.72%, about 0.74%, about 0.76%, about 0.78%, about 0.8%, about 0.81%, about 0.82%, about 0.83%, about 0.84%, about 0.85%, about 0.86%, about 0.87%, about 0.88%, about 0.89%, about 0.9%, about 0.91%, about 0.92%, about 0.93%, about 0.94%, about 0.96%, about 0.98%, about 1%, about 1.05%, about 1.1%, about 1.15%, about 1.2%, about 1.25%, about 1.3%, about 1.35%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w of the composition.

[0300] In some embodiments, the one or more amines are selected from the group consisting of amino acids, panthenol, triethanolamine, and other compounds having a primary, secondary, or tertiary amine. In some embodiments, the one or more amines are one or more amino acids.

[0301] In some embodiments, one or more amines include L-arginine. In some embodiments, one or more amines are L-arginine. In some embodiments, L-arginine is present in an amount of about 0.01% to about 2% w / w of the composition. For example, about 0.01%, about 0.05%, about 0.01%, about 0.1%, about 0.01%, about 0.25%, about 0.01%, about 0.5%, about 0.01%, about 0.75%, about 0.01% to about 1%, about 0.01% to about 1.25%, about 0.01% to about 1.5%, about 0.01% to about 1.75%, about 0.01% to about 2%, about 1.75% to about 2%, about 1.5% to about 2%, about 1.25% to about 2%, about 1% to about 2%, about 0.75% to about 2%, about 0.5% to about 2%, about 0.25% to about 2%, about 0.1% to about 2%, about 0.05% to about 2% w / w. In some embodiments, L-arginine is about 0.25% to about 1.25%, 0.2% to about 0.3%, about 0.25% to about 0.35%, about 0.3% to about 0.4%, about 0.35% to about 0.45%, about 0.4% to about 0.5%, about 0.45% to about 0.55%, about 0.5% to about 0.6%, about 0.55% to about 0.65%, about 0.6% to about 0.7%, about 0.65% to about 0.75%, about 0.7% to about 0.8%, about 0.75% to about 0.85%, about 0.8% to about 0.9%, about 0.85% to about 0.95%, about 0.9% to about 1%, about 0.95% to about 1.05%, about 1% to about 1.1%, about 1.05% to about 1.15%, about 1.1% to about 1.2%, about 1.15% to about 1.25%, about 1.2% to about 1.3%, about 1.25% to about 1.35%, about 1.3% to about 1.4%, about 1.35% to about 1.45%, about 1.4% to about 1.6%, about 1.5% to about 1.7%, about 1.6% to about 1.8%, or about 1.7% to about 1.9% w / w of the composition.For example, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.72%, about 0.74%, about 0.76%, about 0.78%, about 0.8%, about 0.81%, about 0.82%, about 0.83%, about 0.84%, about 0.85%, about 0.86%, about 0.87%, about 0.88%, about 0.89%, about 0.9%, about 0.91%, about 0.92%, about 0.93%, about 0.94%, about 0.96%, about 0.98%, about 1%, about 1.05%, about 1.1%, about 1.15%, about 1.2%, about 1.25%, about 1.3%, about 1.35%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w of the composition.

[0302] In some embodiments, one or more amines include triethanolamine. In some embodiments, one or more amines are triethanolamine. In some embodiments, triethanolamine is present in an amount of about 0.01% to about 2% w / w of the composition. For example, about 0.01%, ~ about 0.05%, about 0.01%, ~ about 0.1%, about 0.01%, ~ about 0.25%, about 0.01%, ~ about 0.5%, about 0.01%, ~ about 0.75%, about 0.01% to about 1%, about 0.01% to about 1.25%, about 0.01% to about 1.5%, about 0.01% to about 1.75%, about 0.01% to about 2%, about 1.75% to about 2%, about 1.5% to about 2%, about 1.25% to about 2%, about 1% to about 2%, about 0.75% to about 2%, about 0.5% to about 2%, about 0.25% to about 2%, about 0.1% to about 2%, about 0.05% to about 2% w / w. In some embodiments, triethanolamine is present in an amount of 0.25% to about 1.25%, about 0.2% to about 0.3%, about 0.25% to about 0.35%, about 0.3% to about 0.4%, about 0.35% to about 0.45%, about 0.4% to about 0.5%, about 0.45% to about 0.55%, about 0.5% to about 0.6%, about 0.55% to about 0.65%, about 0.6% to about 0.7%, about 0.65% to about 0.75%, about 0.7% to about 0.8%, about 0.75% to about 0.85%, about 0.8% to about 0.9%, about 0.85% to about 0.95%, about 0.9% to about 1%, about 0.95% to about 1.05%, about 1% to about 1.1%, about 1.05% to about 1.15%, about 1.1% to about 1.2%, about 1.15% to about 1.25%, about 1.2% to about 1.3%, about 1.25% to about 1.35%, about 1.3% to about 1.4%, about 1.35% to about 1.45%, about 1.4% to about 1.6%, about 1.5% to about 1.7%, about 1.6% to about 1.8%, or about 1.7% to about 1.9% w / w of the composition.For example, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.72%, about 0.74%, about 0.76%, about 0.78%, about 0.8%, about 0.81%, about 0.82%, about 0.83%, about 0.84%, about 0.85%, about 0.86%, about 0.87%, about 0.88%, about 0.89%, about 0.9%, about 0.91%, about 0.92%, about 0.93%, about 0.94%, about 0.96%, about 0.98%, about 1%, about 1.05%, about 1.1%, about 1.15%, about 1.2%, about 1.25%, about 1.3%, about 1.35%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w of the composition.

[0303] In some embodiments, one or more amines include panthenol. In some embodiments, one or more amines are panthenol. In some embodiments, panthenol is present in an amount of about 0.01% to about 2% w / w of the composition. For example, about 0.01%, ~ about 0.05%, about 0.01%, ~ about 0.1%, about 0.01%, ~ about 0.25%, about 0.01%, ~ about 0.5%, about 0.01%, ~ about 0.75%, about 0.01% to about 1%, about 0.01% to about 1.25%, about 0.01% to about 1.5%, about 0.01% to about 1.75%, about 0.01% to about 2%, about 1.75% to about 2%, about 1.5% to about 2%, about 1.25% to about 2%, about 1% to about 2%, about 0.75% to about 2%, about 0.5% to about 2%, about 0.25% to about 2%, about 0.1% to about 2%, about 0.05% to about 2% w / w. In some embodiments, panthenol is present in an amount of 0.25% to about 1.25%, about 0.2% to about 0.3%, about 0.25% to about 0.35%, about 0.3% to about 0.4%, about 0.35% to about 0.45%, about 0.4% to about 0.5%, about 0.45% to about 0.55%, about 0.5% to about 0.6%, about 0.55% to about 0.65%, about 0.6% to about 0.7%, about 0.65% to about 0.75%, about 0.7% to about 0.8%, about 0.75% to about 0.85%, about 0.8% to about 0.9%, about 0.85% to about 0.95%, about 0.9% to about 1%, about 0.95% to about 1.05%, about 1% to about 1.1%, about 1.05% to about 1.15%, about 1.1% to about 1.2%, about 1.15% to about 1.25%, about 1.2% to about 1.3%, about 1.25% to about 1.35%, about 1.3% to about 1.4%, about 1.35% to about 1.45%, about 1.4% to about 1.6%, about 1.5% to about 1.7%, about 1.6% to about 1.8%, or about 1.7% to about 1.9% w / w of the composition.For example, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.72%, about 0.74%, about 0.76%, about 0.78%, about 0.8%, about 0.81%, about 0.82%, about 0.83%, about 0.84%, about 0.85%, about 0.86%, about 0.87%, about 0.88%, about 0.89%, about 0.9%, about 0.91%, about 0.92%, about 0.93%, about 0.94%, about 0.96%, about 0.98%, about 1%, about 1.05%, about 1.1%, about 1.15%, about 1.2%, about 1.25%, about 1.3%, about 1.35%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w of the composition.

[0304] In some embodiments, the aftercare composition can further comprise one or more preservatives. In some embodiments, the one or more preservatives are present in an amount of about 0.01% to about 2% w / w of the composition. For example, about 0.01%, about 0.05%, about 0.01%, about 0.1%, about 0.01%, about 0.25%, about 0.01%, about 0.5%, about 0.01%, about 0.75%, about 0.01% to about 1%, about 0.01% to about 1.25%, about 0.01% to about 1.5%, about 0.01% to about 1.75%, about 0.01% to about 2%, about 1.75% to about 2%, about 1.5% to about 2%, about 1.25% to about 2%, about 1% to about 2%, about 0.75% to about 2%, about 0.5% to about 2%, about 0.25% to about 2%, about 0.1% to about 2%, about 0.05% to about 2% w / w. In some embodiments, the one or more preservatives are present in an amount of 0.25% to about 0.75%, about 0.2% to about 0.3%, about 0.25% to about 0.35%, about 0.3% to about 0.4%, about 0.35% to about 0.45%, about 0.4% to about 0.5%, about 0.45% to about 0.55%, about 0.5% to about 0.6%, about 0.55% to about 0.65%, about 0.6% to about 0.7%, about 0.65% to about 0.75%, about 0.7% to about 0.8%, about 0.75% to about 0.85%, about 0.8% to about 0.9%, about 0.85% to about 0.95%, about 0.9% to about 1%, about 0.95% to about 1.05%, about 1% to about 1.1%, about 1.05% to about 1.15%, about 1.1% to about 1.2%, about 1.15% to about 1.25%, about 1.2% to about 1.3%, about 1.25% to about 1.35%, about 1.3% to about 1.4%, about 1.35% to about 1.45%, about 1.4% to about 1.6%, about 1.5% to about 1.7%, about 1.6% to about 1.8%, or about 1.7% to about 1.9% w / w of the composition.For example, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.72%, about 0.74%, about 0.76%, about 0.78%, about 0.8%, about 0.81%, about 0.82%, about 0.83%, about 0.84%, about 0.85%, about 0.86%, about 0.87%, about 0.88%, about 0.89%, about 0.9%, about 0.91%, about 0.92%, about 0.93%, about 0.94%, about 0.96%, about 0.98%, about 1%, about 1.05%, about 1.1%, about 1.15%, about 1.2%, about 1.25%, about 1.3%, about 1.35%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, or about 2% w / w of the composition.

[0305] In some embodiments, one or more preservatives are ascorbic acid, ascorbate, palmitate, citric acid, benzoate, benzoic acid, propionate, propionic acid, sorbate, sorbic acid, salicylic acid, salicylate, hex-2,4-dienoic acid, hex-2,4-dienoate, formaldehyde, formaldehyde-releasing agents, formic acid and its salts, 3-acetyl-6-methylpyran-2,4-(3H)-dione and its salts, 3,3'-dibromo-4,4'-hexamethylenedioxy dibenzamidine and its salts, thimerosal, phenylmercury salts, undec-10-enoic acid and its salts, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-5-pyrimidine, 5-bromo-5-nitro-1,3-dioxane, bronopol, 2,4-dichlorobenzyl alcohol, 1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea, chlorocresol, chloroxylenol, 5-chloro-2-(2,4-dichlorophenoxy)phenol, N,N”-methylenebis[N’-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea], polyaminopropyl biguanide, methenamine, quaternium-15, climbazole, DMDM hydantoin, benzyl alcohol, 1-hydroxy-4-methyl-6-(2,4,Selected from the group consisting of 4-trimethylpentyl)-2-pyridone, piroctone olamine, bromochlorophen, o-cymen-5-ol, chlorophen, chloroacetamide, methylchloroisothiazolinone, methylisothiazolinone, phenoxyisopropanol, chlorhexidine, chlorhexidine diacetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, dimethyloxazolidine, behentrimonium chloride, cetrimonium bromide, cetrimonium chloride, laurtrimonium bromide, laurtrimonium chloride, steartrimonium bromide, steartrimonium chloride, diazolidinyl urea, hexamidine, hexamidine diisethionate, hexamidine parabens, glutaral, 7-ethylbicyclooxazolidine, chlorphenesin, sodium hydroxymethylglycinate, silver chloride, benzethonium chloride, benzalkonium chloride, benzalkonium bromide, benzalkonium saccharinate, benzyl hemiformal, iodopropynyl butylcarbamate, biphenyl-2-ol and its salts, zinc pyrithione, erythorbate, nitrous acid, ethylenediaminetetraacetic acid (EDTA), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), capric acid, dilauryl thiodipropionate, erythorbic acid, guaiac resin, methylparabens, sulfite, bisulfite, metabisulfite, propyl gallate, propylparabens, stannous chloride, sulfur dioxide, thiodipropionic acid, isothiazoline, parabens, phenoxyethanol, ethylhexylglycerin, glycol, and tocopherol.,

[0306] In some embodiments, the aftercare composition One or more volatile solvents present in an amount of about 30% to about 40% w / w of the composition, and One or more humectants present in an amount of about 20% to about 30% w / w of the composition, and One or more occlusives present in an amount of about 0.2% to about 0.4% w / w of the composition and.

[0307] In some embodiments, the one or more volatile solvents include water and ethanol. In some embodiments, the one or more humectants include glycerin. In some embodiments, the one or more occlusives include acrylate / C10-30 alkyl acrylate crosspolymer.

[0308] In some embodiments, the composition further includes one or more skin softeners. In some embodiments where at least one of the one or more skin softeners also functions as an occlusive, at least one skin softener that also functions as an occlusive is a combination of dimethicone, tricosiloxane, ceteth-10, and laureth-4 (e.g., Dow Corning 7-3110 volatile fluid HIP emulsion). In some embodiments, at least one skin softener that also functions as an occlusive is present in an amount of about 35% to about 40% w / w of the composition.

[0309] In some embodiments, the aftercare composition further includes one or more amines. In some embodiments, the one or more amines are present in an amount of about 0.25% to about 1.25% w / w of the composition.

[0310] In some embodiments, the aftercare composition further includes one or more preservatives. In some embodiments, the one or more preservatives are present in an amount of about 0.25% to about 0.75% w / w of the composition.

[0311] In some embodiments, the aftercare composition water present in an amount of about 30% to about 40% w / w of the composition, glycerin present in an amount of about 20% to about 30% w / w of the composition, acrylate / C10-30 alkyl acrylate crosspolymer present in an amount of about 0.2% to about 0.4% w / w of the composition and.

[0312] In some embodiments, the composition further comprises one or more skin softeners. In some embodiments, at least one of the one or more skin softeners also functions as an occlusive agent. In some embodiments, at least one skin softener that also functions as an occlusive agent is a combination of dimethicone, trisiroxane, ceteth-10, and laureth-4 (e.g., Dow Corning 7-3110 Volatile Fluid HIP Emulsion). In some embodiments, at least one skin softener that also functions as an occlusive agent is present in an amount of about 35% to about 40% w / w of the composition.

[0313] In some embodiments, the aftercare composition further comprises one or more amines. In some embodiments, the one or more amines are selected from the group consisting of triethanolamine, L-arginine, and panthenol. In some embodiments, the one or more amines are present in an amount of about 0.25% to about 1.25% w / w of the composition.

[0314] In some embodiments, the aftercare composition one or more volatile solvents present in an amount of about 65% to about 75% w / w of the composition, and one or more humectants present in an amount of about 20% to about 30% w / w of the composition, and one or more occlusive agents present in an amount of about 0.2% to about 0.4% w / w of the composition and comprises.

[0315] In some embodiments, the one or more volatile solvents include water and ethanol. In some embodiments, the one or more humectants include glycerin. In some embodiments, the one or more occlusive agents include acrylate / C10-30 alkyl acrylate crosspolymer.

[0316] In some embodiments, the aftercare composition further comprises one or more amines. In some embodiments, the one or more amines are present in an amount of about 0.25% to about 1.25% w / w of the composition.

[0317] In some embodiments, the aftercare composition further comprises one or more preservatives. In some embodiments, the one or more preservatives are present in an amount of about 0.25% to about 0.75% w / w of the composition.

[0318] In some embodiments, the aftercare composition comprises water present in an amount of about 60% to about 75% w / w of the composition, glycerin present in an amount of about 20% to about 30% w / w of the composition, and acrylate / C10-30 alkyl acrylate crosspolymer present in an amount of about 0.2% to about 0.4% w / w of the composition.

[0319] In some embodiments, the composition further comprises ethanol. In some embodiments, water is present in an amount of about 60% to about 70% w / w of the composition and ethanol is present in an amount of about 5% to about 15% w / w of the composition.

[0320] In some embodiments, the aftercare composition further comprises one or more amines. In some embodiments, the one or more amines are selected from the group consisting of triethanolamine, L-arginine, and panthenol. In some embodiments, the one or more amines are present in an amount of about 0.25% to about 1.25% w / w of the composition.

[0321] In some embodiments, the aftercare composition can be configured to have a pH of about 4 to about 7. For example, about 4 to about 5, about 4.5 to about 5.5, about 5 to about 6, about 5.5 to about 6.5, or about 6 to about 7. In some embodiments, the aftercare composition can be configured to have a pH of about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, or about 7.

[0322] ​In some embodiments, the aftercare composition can have a pH of from about 4 to about 7. For example, from about 4 to about 5, from about 4.5 to about 5.5, from about 5 to about 6, from about 5.5 to about 6.5, or from about 6 to about 7. In some embodiments, the aftercare composition can have a pH of about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, or about 7.

[0323] In some embodiments, the aftercare composition provided herein can further comprise one or more semi-volatile semi-permanent colorant solubilizers described herein.

[0324] In some embodiments, the aftercare composition provided herein can be formulated as a serum, cream, mousse, semi-solid stick, spray, moisturizing patch, or roll-on.

[0325] In some embodiments, a suitable aftercare composition can include a fragrance-free lotion. For example, the fragrance-free lotion can have the following ingredients, water, grape seed oil (Vitis vinifera), fully emulsified wax B, glycerin (e.g., vegetable glycerin), vitamin E oil, and a combination of benzyl alcohol, salicylic acid, glycerin, and sorbic acid (e.g., GEOGARD® ECT).

[0326] In some embodiments, the aftercare composition is applied to a subject after applying semi-permanent tattoo ink to the subject. For example, after application of the semi-permanent tattoo ink, for about 5 minutes, about 15 minutes, about 30 minutes, about 1 hour, or about 2 hours. In some embodiments, the aftercare composition is applied to the subject daily. For example, once, twice, three times, four times, five times, or more times per day. In some embodiments, the aftercare composition is applied to the subject every other day or every three days. In some embodiments, the aftercare composition is applied to the subject daily during the semi-permanent tattoo ink period.

[0327] In some embodiments, the aftercare composition is applied to the subject after bathing. In some embodiments, the aftercare composition is applied to the subject after cleansing the area of skin to which the semi-permanent tattoo has been applied. In some embodiments, the aftercare composition is applied to the subject after the subject has exercised.

[0328] Also provided herein are aftercare articles moistened with an aftercare composition of any of the above embodiments. In some embodiments, the moistened article can be a towel, pad, woven fabric, non-woven fabric, and the like. In some embodiments, the moistened article can be housed in a sealed package to maintain the moist nature of the article.

[0329] Also provided herein is a method for extending the duration of a semi-permanent tattoo on the skin, including applying an aftercare composition of any of the above embodiments. In some embodiments, the method for extending the duration of a semi-permanent tattoo on the skin includes extending the duration of the semi-permanent tattoo in the stratum corneum. In some embodiments, extending the duration of the semi-permanent tattoo includes reducing the loss of intensity of the semi-permanent tattoo after application to the skin as compared to the loss of intensity of the semi-permanent tattoo not exposed to the aftercare composition.

[0330] In some embodiments, the semi-permanent tattoo is applied to the skin of the subject before applying the aftercare composition. In some embodiments, the aftercare composition is applied to the skin of the subject after applying the semi-permanent tattoo to the subject. For example, about 5 minutes, about 15 minutes, about 30 minutes, about 1 hour, or about 2 hours after application of the semi-permanent tattoo. In some embodiments, the aftercare composition is applied to the skin of the subject immediately after the semi-permanent tattoo is applied to the skin of the subject. In some embodiments, the aftercare composition is applied daily to the skin of the subject. For example, once, twice, three times, four times, five times, or more times a day. In some embodiments, the aftercare composition is applied to the skin of the subject every other day, every three days, or weekly. In some embodiments, the aftercare composition is applied daily to the skin of the subject during the period of the subject's semi-permanent tattoo. In some embodiments, the aftercare composition is applied to the area of the skin of the subject to which the semi-permanent tattoo is applied.

[0331] Also provided herein is a method for applying a temporary tattoo ink to an article.

[0332] In some embodiments, the ink composition (e.g., ink composition 60 of FIG. 1) is applied to the first surface 121 of the first adhesive layer 120 as shown in FIG. 2A.

[0333] In some embodiments, the ink composition 160 is applied by inkjet printing.

[0334] In some embodiments, the ink composition (e.g., ink composition 60 of FIG. 1) is applied to the first surface of the first adhesive layer 220 described in connection with FIG. 3.

[0335] In some embodiments, the ink composition 260 is applied by inkjet printing.

[0336] In some embodiments, an ink cartridge of an inkjet printer used to print the ink composition as described above onto the adhesive applicator article as described above can be filled with two different ink compositions. For example, when two ink cartridges are used in a printer, one ink cartridge, e.g., a dark cyan cartridge, can be filled with an ink composition having a higher concentration of semi-permanent colorant and / or temporary colorant than the ink composition filled in the second ink cartridge, e.g., a light cyan cartridge.

[0337] Also provided herein is a kit comprising any one of the adhesive applicator articles of the embodiments of the adhesive applicator article described above. In some embodiments, the adhesive applicator article is an adhesive applicator article with a heat pad. In some embodiments, the kit further comprises a heat pad (e.g., separated from the adhesive applicator article). In some embodiments, the adhesive applicator article is an adhesive applicator article with an occlusion patch. In some embodiments, the kit further comprises a skin priming composition of any of the above embodiments. In some embodiments, the kit further comprises a skin priming composition of any of the above embodiments. In some embodiments of the kit, a priming article, e.g., a towelette, can be provided with the skin priming composition. In some embodiments, the skin priming composition can be provided in the kit on a priming article, e.g., a towelette, pre-moistened with the skin priming composition. In some embodiments, the kit further comprises instructions.

[0338] This specification also provides a kit comprising any one of the adhesive applicator articles of the above-described embodiments of the adhesive applicator article and any of the skin priming compositions of the above-described embodiments. In some embodiments, the adhesive applicator article is an adhesive applicator article with a heat pad. In some embodiments, the kit further comprises a heat pad (e.g., separated from the adhesive applicator article). In some embodiments, the adhesive applicator article is an adhesive applicator article with an occlusion patch. In some embodiments, the kit further comprises a towelette. In some embodiments, the towelette is moistened with the skin priming composition. In some embodiments of the kit, a priming article, such as a towelette, may be provided with the skin priming composition. In some embodiments, the skin priming composition may be provided in the kit on a priming article, such as a towelette, pre-moistened with the skin priming composition. In some embodiments, the kit further comprises instructions. In some embodiments, the kit further comprises an aftercare composition as described herein.

[0339] This specification also provides a kit comprising any one of the adhesive applicator articles of the above-described embodiments of the adhesive applicator article, any of the skin priming compositions of the above-described embodiments, and a heat pad. In some embodiments of the kit, a priming article, such as a towelette, may be provided with the skin priming composition. In some embodiments, the skin priming composition may be provided in the kit on a priming article, such as a towelette, pre-moistened with the skin priming composition. In some embodiments, the kit further comprises instructions. In some embodiments, the kit further comprises an aftercare composition as described herein.

[0340] Additional preliminary ink (temporary and / or semi-permanent colorants) can be added to each of the above kits to enable, for example, correction, personalization, recoloring, etc. of semi-permanent tattoos by handwritten application. In some embodiments, the preliminary ink can have a composition as described in U.S. Patent No. 10,143,641, which is incorporated herein by reference in its entirety as above.

[0341] A kit comprising an inkjet composition and / or an inkjet printing cartridge containing the inkjet composition, and an applicator article on which the composition is not printed for printing a custom design using an inkjet printer or for the user to hand-draw a design on the applicator prior to application.

Examples

[0342] The present invention is described in more detail by specific examples. The following examples are provided for illustrative purposes and are intended to illustrate the topical compositions and methods described herein, and are not intended to limit the invention in any way. Many variations are suggested and are within the fully intended scope. Those skilled in the art will readily recognize various non-essential parameters that can be changed or modified to produce essentially the same results.

[0343] Example 1. Ink Composition A. Preparation of Ink Composition As shown in Table 1, 15 ink compositions were prepared. (Table 1) Ink Composition TIFF0007710989000001.tif152170

[0344] For the ink composition of Table 2, solids (genipin, trehalose, and HPMC) were weighed. Next, liquids (water, buffer solution, ethanol, and diethylene glycol monoethyl ether) were weighed together in a 250 mL beaker. Next, the liquids were placed in a mechanical mixer and mixed at a speed of 400 RPM. The beaker was also covered with PVC plastic wrap to prevent evaporation of the volatile solution. Trehalose was added to the mixture in an aliquot and mixed thoroughly until all was dissolved. Next, the beaker was removed from the mixer and placed on a weighing machine, and a surfactant / preservative was added. The preservative and surfactant in this composition refer to EUXYL® PE9010 (e.g., 9:1 phenoxyethanol:ethylhexylglycerin) and PEG400, respectively. Next, the resulting mixture was mixed using a mechanical mixer at 400 RPM until a uniform solution was obtained. While mixing, genipin solids were added to the resulting solution and mixed thoroughly until a uniform solution was obtained. The resulting mixture was placed in a vacuum filter with a pore size of 1.2 microns and filtered into a sterile glass jar. (Table 2) Ink composition TIFF0007710989000002.tif71169*EUXYL® PE9010 is about 9:1 phenoxyethanol:ethylhexylglycerin

[0345] As shown in Tables 3 and 4, additional ink compositions were prepared. (Table 3) Ink composition TIFF0007710989000003.tif47169(Table 4) Ink composition TIFF0007710989000004.tif47169

[0346] B. Characterization determination method Characteristic Determination Method #1: In Vitro Film Dissolution Preparation of the dissolution solution To prepare the dissolution solution, 54 mL of Fisher Scientific pH 4.1 buffer (simulating the pH of eccrine sweat) was added to a 200 mL volumetric cylinder, followed by 0.469 g of L-arginine. The solution was stirred until the L-arginine was completely dissolved. Then, 6 mL of isopropanol was added to a 200 mL beaker. The dissolution solution was stored in an airtight 25 mL scintillation vial.

[0347] Preparation of Samples and Test Sites Disperse 3 mL of the ink composition described in Table 1 or 2 uniformly onto a 9 cm Petri dish coated. Place the sample in a dehydrator at 150°F for 2 hours to form a film. Record the physical properties of the film such as the elapsed time since film casting, genipin crystal form, color and transparency, uniformity, and thickness. Since the crystal form may vary depending on the conditions, all samples tested from the same batch are stored under the same chamber conditions.

[0348] Experiment Add 20 mL of the dissolution solution to each Petri dish containing the cast film and heat to 40°C. Record the elapsed time until the color corresponding to the color scale in Figure 5 is achieved over 60 seconds. Also record the total time required for the film to dissolve in the dissolution solution.

[0349] Characteristic Determination Method #2: In Vitro Printed Substrate Total Content Analysis Genipin dissolution from the dried printed adhesive substrate was measured using high-performance liquid chromatography (HPLC). For compositions 3, 4, and 9, printed samples adhered onto a 2x2 cm adhesive substrate were placed in a 9 cm diameter Petri dish and immersed in 10 mL of methanol for 30 minutes. Next, the adhesive was removed from the Petri dish and rinsed in a vial containing 25 mL of methanol for 30 seconds each. Then, the adhesive was removed and immersed in 25 mL of methanol for 24 hours for extraction. The extraction solution was evaporated to recover the extracted genipin. Next, the total genipin content was determined via HPLC.

[0350] Characteristic Determination Method #3: Quantitative Analysis of Genipin Dissolution from Printed Adhesive Substrate The dissolution buffer is prepared by adding 54 mL of Fisher Scientific pH 4.1 buffer to a 200 mL beaker, followed by 6 mL of isopropanol.

[0351] A test sample containing a 2-inch × 2-inch printed ink area is printed onto the adhesive substrate using 5 printer passes. The printed sample is stored for a specified period to determine the stability of genipin release.

[0352] The Petri dish is heated to 40 °C. Each test sample is adhered to the Petri dish (1 test sample per Petri dish) using double-sided tape. 20 mL of the dissolution buffer is poured into the covered Petri dish and the test sample is immersed for 60 minutes. The dissolution buffer is removed using a syringe and transferred to a scintillation vial for HPLC analysis.

[0353] Characteristic Determination Method #4: Quantification of Skin Ink Concentration Profile Test Protocol The test semi-permanent tattoo is applied to study participants who meet the criteria determined by the research staff, who have not had a semi-permanent tattoo applied at the test site within the past 2 weeks, have not used a topical product at the test site within the past 24 hours, and have no other skin injuries that would interfere with digital analysis. Two different test sites are selected for each study participant and two predetermined test articles are applied. Some of the test sites are located on the upper volar forearm and contain 4 square semi-permanent tattoos as shown in Figure 6. Other test sites include the inner upper arm. Each test site is gently wiped with an ethanol wipe and lightly tapped with a KIMWIPE (trademark) to dry. The adhesive of the newly printed semi-permanent tattoo is affixed to the test site. After 1 hour, the applicator is removed.

[0354] For liquid compositions, the designated research staff applies 0.05 g of the test article to each of the 4 squares.

[0355] Ink Concentration Data Collection Photography Using a standardized photographic set as shown in Figure 7, photographs of the test site (including each of the four inked squares) are taken at each time point before each tape peel of the inked squares. Following the last tape strip, the last photograph is taken. A total of 21 photographs are taken at each time point for each inked square, and a total of 64 photographs are generated for the entire test site to be evaluated using the Image J process. The Canon EOS77D and ultrasonic macro lens are used with the standardized photographic set to capture the skin site with semi-permanent tattooing.

[0356] Visual Grading Designated evaluators not participating in the study grade the ink intensity on a scale of 0 - 4 using the guidelines in Table 5 (before tape stripping after each tape strip is removed). (Table 5) TIFF0007710989000005.tif42128

[0357] Study participants evaluate the test site at each time point before the site is tape stripped and after each tape strip is removed using the guidelines in Table 6. (Table 6) TIFF0007710989000006.tif34128

[0358] Tape Strip In accordance with the guidelines of Lademann et al., Eur. J. Pharm. Biopharm. 72:317-323, 2009, which are incorporated herein by reference in their entirety, at each predetermined time point, a designated member of the research staff removes a total of 20 tape strips from the square with each ink. The designated member of the research staff uses sterilized tweezers to peel a pre-cut 1.5-inch × 1.5-inch single-sided adhesive square from the sheet and apply it to a predetermined test site. A roller is used to apply uniform pressure to the adhesive to ensure that the adhesive makes good contact with the skin. The adhesive is removed, and the tape is pulled in the direction of hair growth and lowered towards the skin at a constant speed. Next, the square of the adhesive is placed on a slide glass, and the formulation, time point, and tape strip number are marked. The slide glass with the square of the adhesive is retained for previous analysis.

[0359] The data are analyzed such that 1) the ink concentration is plotted at each time point according to the number of tape strips, 2) the photographs are reprocessed in ImageJ using two macros of percent green and color histogram, and 3) the change in the statistical pixel intensity distribution is analyzed to track the shift to darker pixel intensity. The change in the statistical pixel intensity distribution is used to determine darkness and measure the color development of the ink (or the polymerization and / or oligomerization of genipin). The color histogram is used to plot the standard deviation and mode of the blue and green pixel intensities at each time point to evaluate the amount of color development of the ink.

[0360] Characteristic Determination Method #5: Stability of Printed Ink Composition The adhesive substrate containing the printing ink was placed at 25 °C and 60% indoor humidity (normal condition) and at 40 °C and 75% indoor humidity (accelerated condition) for two weeks. At the two-week time point, the samples were removed from the stability chamber and subjected to dissolution tests and content analysis.

[0361] Semi-permanent tattoos were applied and allowed to develop for 36 hours. The results of the skin transfers were visually graded based on the ink intensity scale of 0 - 8 and ink density scale shown in FIG. 8A, as well as the image quality scale of 1 - 8 shown in FIG. 8B.

[0362] Characteristic Determination Method #6: Viscosity and Surface Tension of Composition The viscosity of all measured compositions was measured using a Brookfield Ametek DVE viscometer, model number DVEELVTJ0.

[0363] The tensiometer used to obtain the surface tension and contact angle measurements was a Droplet Labs Drop-O-Meter automatic or manual tensiometer, and the data was processed using the Sessile data processing application.

[0364] C. Results of Characterizing the Ink Compositions In Vitro Printed Substrate Total Content Analysis Table 7 shows the formulation numbers and corresponding adhesives used for the extraction and measurement of genipin content by HPLC. (Table 7) TIFF0007710989000007.tif113140 FIG. 9 shows the amount of genipin extracted from each dried printed adhesive substrate.

[0365] Stability of Printed Ink Composition The results of the skin transfer grading of the compositions and stable adhesive substrates in Table 1 are summarized in Tables 8 and 9 for normal and accelerated conditions, respectively. (Table 8) Visual Skin Transfer Grading in Normal Conditions (25 °C, 60% Humidity) TIFF0007710989000008.tif100159 (Table 9) Visual Skin Transfer Grading in Accelerated Conditions (40 °C, 70% Humidity) TIFF0007710989000009.tif102141

[0366] Surface Tension and Viscosity Table 10 shows the measured surface tensions and viscosities of the compositions described in Table 1. (Table 10) Measured Values of Surface Tension and Viscosity TIFF0007710989000010.tif112128

[0367] Example 2. Skin Priming Composition A. Skin Priming Composition #1 As shown in Table 11, a skin priming composition was prepared. (Table 11) Skin Priming Composition #1 TIFF0007710989000011.tif45128

[0368] 1 mL of the skin priming composition was filled into a toilet (diamond wipe 80 gsm rayon non-woven wipe 7” x 3”). The toilet was used to apply, peel, wash, and attach the skin priming composition to the semi-permanent tattoo application site. Immediately after treatment, a semi-permanent tattoo applicator was applied to the treated skin site and removed after 1 hour. Figure 10 shows the enhanced color density as a result of the skin priming treatment. The color density of the primed skin was comparable to that of the semi-permanent tattoo with a heat pad applied to unprimed skin, and both had a performance of 8 on a color intensity scale of 0 - 8 (Figure 11).

[0369] B. Skin Priming Composition #2 As shown in Table 12, a skin priming composition was prepared. (Table 12) Skin Priming Composition #2 TIFF0007710989000012.tif27128

[0370] The skin priming composition was filled into a toilet (diamond wipe 80 gsm rayon non-woven wipe 7” x 3”) at a skin priming composition to wipe mass ratio of 1:2.

[0371] B. Skin Priming Composition #3 As shown in Table 13, a skin priming composition was prepared. (Table 13) Skin Priming Composition #2 TIFF0007710989000013.tif39128

[0372] The skin priming composition was filled into a toilet paper (3”×4” span lace 80 gsm 100% rayon, with embossed dots) at a skin priming composition to wipe mass ratio of 1:2.

[0373] Example 3. Preparation of a Semi-Permanent Tattoo Applicator Preparation of Materials The 12-inch section on the unwind side of the 3M 1509 adhesive is laminated to the unwind side of the Argotec 1.4 mil PU. Next, the laminated section is cut into 3-inch×3-inch squares. Next, the casting liner of the Argotec 1.4 mil PU is removed to expose the polyurethane.

[0374] Template Assembly A 4×4 matrix Adobe illustrator file of the semi-permanent tattoo design of interest is printed on A4 paper using an Epson DTG printer. A strip of Scotch permanent double-sided tape is adhered to the template along the perimeter of the design. A 3”x3” semi-permanent tattoo blank is adhered to the template with the Argotec side down.

[0375] Printing The template is edited to remove the border surrounding the design. A box is added to the lower part of the template as a print quality checker. The template is printed on the blank. This is repeated 5 times, and another box is added to the template for quality control.

[0376] Dehydration and Final Packaging Place the template in a dehydrator set at 60°C for 90 minutes. Remove the template from the dehydrator and place the silicone coating liner of 3M1509 adhesive on the printing surface. To ensure that there is no movement of the formulation, remove and replace a single liner. The semi-permanent tattoo is classified by the design packaged in a transparent polyethylene bag.

[0377] Example 4. Preparation of Aftercare Composition As shown in Table 14, prepare seven aftercare compositions. (Table 14) Aftercare Composition TIFF0007710989000014.tif119170*pH 5 until

[0378] Example 5. Ink Composition An ink composition as shown in Table 15 was prepared. Solids (genipin, trehalose, and Acid Blue 9, such as FD&C Blue No. 1 dye) were weighed into a clean weighing boat. Next, volatile solvents (water, ethanol, and diethylene glycol monoethyl ether, such as TRANSCUTOL®) were weighed into separate clean beakers with a capacity of 500 mL to 2 L. Next, the solid genipin was added to ethanol, a magnetic stirrer was added, and the mixture was stirred either by placing it on a magnetic mixer or by lowering the impeller of a mechanical mixer into the solution and mixing at a speed of 400 RPM. The beaker was also covered with PVC plastic wrap to prevent evaporation of the volatile solvent. Next, trehalose was added to the beaker containing water, a magnetic stirrer was added, and the mixture was stirred either by placing it on a magnetic mixer or by lowering the impeller of a mechanical mixer into the solution and mixing at a speed of 400 RPM. Next, the beaker containing diethylene glycol monoethyl ether was placed on a balance, and 1,2 - hexanediol (such as OPTIPHEN® HD), phenoxyethanol, and ethylhexylglycerin (such as EUXYL® PE9010) were added. A magnetic stirrer was added, and the mixture was stirred either by placing it on a magnetic mixer or by lowering the impeller of a mechanical mixer into the solution and mixing at a speed of 400 RPM. Next, the ethanol solution and the diethylene glycol monoethyl ether (such as TRANSCUTOL®) solution were added to the aqueous solution. Next, the resulting mixture was mixed using a mechanical mixer at 400 RPM until a uniform solution was obtained. Next, the resulting mixture was partially decanted onto a ceramic filter funnel containing a moistened filter paper strip, and the solution was vacuum filtered into an attached vacuum flask. Next, the filtered solution was decanted into a 250 mL or 500 mL plastic bottle sterilized with ethyl alcohol, sealed with a screw cap and parafilm, and placed in a cool, dark place for storage. (Table 15) Ink Composition TIFF0007710989000015.tif100146

[0379] Example 6. Performance of Semi-Permanent Tattoo Lifespan and Stability To study the lifespan of the ink composition of Example 5, the overall appearance, density, fading, spotting, and bleeding were evaluated (see Table 16). The study was conducted on 20 internal participants at different locations on the body using the ink composition of Example 5 adhered in combination with adhesive patch articles and occlusion patch articles. This study showed that the general trend of the lifespan was 1 - 2 weeks (see Figure 24).

[0380] A scoring system was set up to evaluate the overall performance of the semi-permanent tattoo using the ink composition of Example 5 after application to the skin (see Table 16). This evaluation was carried out daily for 14 days. (Table 16) Scoring System for Evaluating Overall Performance TIFF0007710989000016.tif176170

[0381] The application of semi-permanent tattoo requires the use of a primer wipe to promote the color development of the dye on the skin. The process for applying the semi-permanent tattoo was as follows: Using a primer wipe, the skin was completely exfoliated for 30 seconds in a circular motion in the area where the semi-permanent tattoo was to be applied. Wiping with the primer wipe makes it smooth due to exfoliation and can give moisture to the skin in the preparation of the semi-permanent tattoo. Next, the application area was dried.

[0382] With a semi-permanent tattoo (e.g., the ink composition of Example 5 adhered to a combination of an adhesive patch article and an occlusion patch article) in hand, the central portion of the semi-permanent tattoo liner was removed and discarded, exposing the transparent adhesive and ink composition of Example 5. The adhesive side of the adhesive was placed on the skin, and air bubbles were gently squeezed out. When the semi-permanent tattoo was placed, the liner of the semi-permanent tattoo was removed. At this point, the entire semi-permanent tattoo liner was removed from the semi-permanent tattoo applicator. The semi-permanent tattoo was firmly pressed against the skin for 5 seconds to ensure that the adhesive was in optimal contact with the skin.

[0383] The semi-permanent tattoo was left on the skin for 60 minutes. During this time, the skin should interact with the ink composition of Example 5. To prevent peeling, excessive movement and sweating should be avoided. The semi-permanent tattoo should not be left on for more than 60 minutes.

[0384] The adhesive of the semi-permanent tattoo was slowly removed to ensure that all the ink was securely transferred to the skin. The semi-permanent tattoo of the ink composition of Example 5 should initially appear blue / green and develop into a fully dark blue or black color within the next 24 - 36 hours.

[0385] The performance of the semi-permanent tattoo may depend on the skin tone as the product develops color differently in each case (Figs. 25A and 25B).

[0386] To evaluate the shelf life, stability evaluations were conducted over a three-month period. The performance evaluation (see Table 16) consisted of (a) applying the semi-permanent tattoo to the subject's forearm, (b) removing the semi-permanent tattoo applicator after 60 minutes, (c) taking a photograph after application, (d) providing aftercare recommendations, and (e) taking photographs 24 hours, 48 hours, and 14 days after application. The aftercare recommendations were as follows: moisturize the semi-permanent tattoo daily with an amount of fragrance-free aqueous moisturizer the size of a dime (see example ingredient list below), drink plenty of water for hydration, gently smooth the semi-permanent tattoo with a soft towel after showering and blot dry, avoid rubbing the semi-permanent tattoo, and avoid abrading the tattoo through daily activities. Examples of aqueous moisturizers for daily use may include distilled water (aqua), grapeseed oil (Vitis Vinifera), fully emulsified wax B, vegetable glycerin, vitamin E oil (tocopheryl acetate), GEOGARD® ECT (e.g., a combination of benzyl alcohol, salicylic acid, glycerin, sorbic acid).

[0387] By repeating the above evaluations several times, it was determined that these semi-permanent tattoos could maintain their initial performance even after 10 weeks. That is, the 10-week semi-permanent tattoos were of equal sharpness and intensity when transferred to the skin compared to newly printed semi-permanent tattoos.

[0388] Other embodiments Although the invention has been described in detail with its specific embodiments, it should be understood that the foregoing description is illustrative only and is not intended to limit the scope of the invention, which is defined by the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.

Claims

1. One or more semi - permanent colorants, one or more volatile solvents, and one or more semi - volatile semi - permanent colorant solubilizers comprising a genipin - based composition for application to the skin, wherein the one or more volatile solvents is a combination of water and ethanol, the one or more semi - volatile semi - permanent colorant solubilizers are selected from the group consisting of polyethylene glycol, alkyl glycol, and alkylene glycol ether, the composition further comprises one or more matrix components, and the matrix components are sugars selected from the group consisting of trehalose, glucose, fructose, galactose, ribose, xylose, sucrose, lactotrehalose, galactotrehalose, 6 - azidotrehalose, maltose, lactose, lactulose, cellobiose, and chitobiose.

2. The composition according to claim 1, having a viscosity of 1 - 7 centipoises and / or a surface tension of 20 - 35 dynes / cm.

3. The composition according to claim 1 or 2, wherein the one or more semi - permanent colorants are present in an amount of 0.1% - 20% w / w of the composition.

4. The composition according to any one of claims 1 - 3, wherein the water is present in an amount of 25% - 35% w / w of the composition and the ethanol is present in an amount of 35% - 50% w / w of the composition.

5. The composition according to any one of claims 1 - 4, wherein the one or more semi - volatile semi - permanent colorant solubilizers are selected from the group consisting of alkylene glycol ethers and / or the one or more semi - volatile semi - permanent colorant solubilizers are present in an amount of 0.1% - 25% w / w of the composition.

6. The composition according to any one of claims 1 - 5, wherein the one or more semi - volatile semi - permanent colorant solubilizers is diethylene glycol monoethyl ether.

7. The composition according to any one of claims 1 - 6, wherein the composition further comprises one or more surfactants, the one or more surfactants are selected from the group consisting of alkylbenzene sulfonate, alkyl sulfate, alkyl ether sulfate, alkyl alcohol, soap, ethoxylate, lignosulfonate, and triglyceride, and / or the one or more surfactants are present in an amount of 0.1% - 5% w / w of the composition.

8. The composition according to claim 7, wherein the one or more surfactants are 1,2 - hexanediol.

9. The composition according to any one of claims 1 to 8, wherein the one or more matrix components are present in an amount of 0.1% to 10% w / w of the composition.

10. The composition according to any one of claims 1 to 9, wherein the one or more matrix components are trehalose.

11. The composition according to any one of claims 1 to 10, wherein the composition further comprises one or more skin penetration enhancers, and the one or more skin penetration enhancers are selected from the group consisting of alcohols (except ethanol), amides, esters, ether alcohols, fatty acids, glycols, pyrrolidones, sulfoxides, and terpenes, and / or the one or more skin penetration enhancers are present in an amount of 0.1% to 50% w / w of the composition.

12. The composition according to claim 11, wherein the one or more skin penetration enhancers are selected from the group consisting of isopropanol, decanol, hexanol, lauryl alcohol, myristyl alcohol, octanol, octyldodecanol, oleyl alcohol, ethyl acetate, octyl salicylate, padimate O, ethyl oleate, glyceryl monooleate, glyceryl monocaprylate, glyceryl tricaprylate, isopropyl myristate, isopropyl palmitate, propylene glycol monolaurate, propylene glycol monocaprylate, diethylene glycol monoethyl ether, lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, stearic acid, isostearic acid, dipropylene glycol, propylene glycol, 1,2 - butylene glycol, 1,3 - butylene glycol, n - methyl - 2 - pyrrolidone, 2 - pyrrolidone, decyl methyl sulfoxide, dimethyl sulfoxide, sodium lauryl sulfate, alkyl dimethyl benzyl ammonium halide, alkyl trimethyl ammonium halide, alkyl pyridinium halide, polyethylene glycol sorbitan monooleate, eugenol, D - limonene, menthol, mentone, farnesol, and neridol.

13. The composition according to any one of claims 1 to 12, wherein the composition further comprises one or more temporary colorants.

14. The one or more temporary colorants are present in an amount of 0.1% to 1% w / w of the composition, and / or the one or more temporary colorants are iron oxide black (Fe ３ O ４ ), iron oxide (FeO), carbon, logwood, loess, cinnabar (HgS), cadmium red (CdSe), iron(III) oxide (Fe ２ O ３ ), naphthol-AS pigment, disazo diarylide, disazo pyrazolone, cadmium selenosulfide, cadmium yellow (CdS, CdZnS), curcuma yellow, chrome yellow (PbCrO ４ ), disazo diarylide, chromium oxide (Cr ２ O ３ ), malachite [Cu ２ (CO ３ )(OH ２ , ferrocyanide, ferricyanide, lead chromate, monoazo pigment, Cu / Al phthalocyanine, Cu phthalocyanine, azurite blue, cobalt blue, Cu-phthalocyanine, manganese violet (ammonium manganese pyrophosphate), aluminum salt, quinacridone, dioxazine / carbazole, lead white (lead carbonate), titanium dioxide (TiO ２ ),(barium sulfate (BaSO4), zinc oxide, anthraquinone dyes and derivatives, anatase, caramel, β-carotene, bismuth citrate, disodium EDTA copper, potassium sodium copper chlorophyllin, dihydroxyacetone, bismuth oxychloride, guaiazulene, henna, iron ammonium ferrocyanide, iron ferrocyanide, chromium hydroxide green, chromium oxide green, guanine, lead acetate, pyrophyllite, mica, silver, titanium dioxide, aluminum powder, bronze powder, copper powder, ultramarine, manganese violet, zinc oxide, luminescent zinc sulfide, D&C Black No. 2 and 3, FD&C Blue No. 1, D&C Blue No. 4, D&C Brown No. 1, FD&C Green No. 3, D&C Green No. 5, 6 and 8, D&C Orange No. 4, 5, 10 and 11, FD&C Red No. 4, D&C Red No. 6, 7, 17, 21, 22, 27, 28, 30, 32, 33, 34, 36, and 40, D&C Violet No. 2, Ext. D&C Violet No. 2, FD&C Yellow No. 5 and 6, D&C Yellow No. 7, 8, 10 and 11, and Ext. D&C Yellow No. 7), a composition according to claim 13, selected from the group consisting of.

15. The composition according to any one of claims 1 to 14, wherein the composition has a pH of 4 to 7.

16. The composition according to any one of claims 1 to 15, wherein the composition further comprises one or more preservatives, the one or more preservatives are phenoxyethanol and ethylhexylglycerin, and / or the one or more preservatives are present in an amount of 0.5% to 1.5% w / w of the composition.

17. The composition according to any one of claims 1 to 16, wherein the one or more semi-permanent colorants are genipin.

18. The composition according to claim 17, wherein the genipin is purified genipin.

19. The composition according to any one of claims 1 to 18, wherein the composition is for printing on the surface of an adhesive by an inkjet printer.

20. The composition according to any one of claims 1 to 19, wherein the composition is for transferring from an adhesive to the skin in a single step.

21. An adhesive applicator article, comprising: the composition according to any one of claims 1 to 20; an adhesive layer; an adhesive backing; An adhesive applicator article comprising the above.

22. The adhesive applicator article according to claim 21, further comprising a liner.

23. The adhesive applicator article according to claim 22, wherein the liner is composed of a non-adhesive material.

24. A method for manufacturing the adhesive applicator article according to any one of claims 21 to 23, wherein the adhesive layer includes a first surface and a second surface opposite to the first surface, the composition is disposed and / or bonded to at least a part of the first surface of the adhesive layer, The manufacturing method, wherein the composition is printed on the first surface of the adhesive layer by an inkjet printer.

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