Oral composition for liquid in a foam discharging container

Abstract

To provide a liquid oral composition in a foam dispensing container that provides a lasting and comfortable refreshing feeling from the time it is applied to the oral cavity until after it is spit out of the mouth.SOLUTION: Provided is a liquid oral composition in foam dispensing container, comprising the following ingredients (A) and (B): (A) 0.01 mass% or more and 0.45 mass% or less of menthol; and (B)2-(4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(2-thienylmethyl)acetamide, the mass ratio ((B) / (A)) between the content of component (B) and the content of component (A) being 0.0014 or more and 0.02 or less, and the content of one or more polyols (C) selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol being less than 40 mass%.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a liquid oral composition contained in a foam discharge container.

Background Art

[0002] A liquid oral composition filled in a container capable of discharging the contents in a foamed state can be applied in a foamed state from the discharge port into the oral cavity during use, is easily adhered to the tongue and mucous membranes, and is easily spread to every corner of the oral cavity, and is thus preferred by many users. On the other hand, if menthol is blended in the liquid oral composition, it is also known that a good flavor and feeling of use can be brought during use. For example, Patent Document 1 discloses a liquid oral composition containing a fragrance such as menthol and an amphoteric surfactant in a specific mass ratio and containing a nonionic surfactant in a specific amount, and attempts have been made to stably contain a high content of the fragrance. Further, Patent Document 2 discloses a liquid oral composition contained in a foam discharge container containing an alkyl galactoside, a lactone compound, and a cooling agent such as L-menthol in specific amounts, enabling foamed application into the oral cavity, effectively masking the off-flavor derived from the alkyl galactoside, and enabling the fragrance of the lactone compound to be strongly felt without making it feel strong.

[0003]

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

[0005] However, in the technology described in the above patent document, not only immediately after applying the composition in the oral cavity, but also after spitting it out outside the oral cavity, if the content of menthol is increased to bring a refreshing feeling, there is a risk that the irritation will become unnecessarily strong immediately after application in the oral cavity. Thus, there is still room for improvement in order to continuously provide a comfortable refreshing feeling from immediately after application in the oral cavity to after spitting it out outside the oral cavity. That is, the present invention relates to a liquid oral composition that can continuously provide a comfortable refreshing feeling from immediately after application in the oral cavity to after spitting it out outside the oral cavity.

[0006] That is, the present invention relates to a liquid oral composition that can continuously provide a comfortable refreshing feeling from immediately after application in the oral cavity to after spitting it out outside the oral cavity. Means for Solving the Problems

[0007] Therefore, the present inventors conducted various studies and found that by containing menthol and a specific acetamide compound in specific contents and a mass ratio, while restricting the content of a specific polyol, and filling a foam discharge container for application in the oral cavity in a foamed state, it is possible to provide a comfortable refreshing feeling from when applied in the oral cavity to after spitting it out outside the oral cavity.

[0008] Accordingly, the present invention provides the following components (A) and (B): (A) Menthol: 0.01% by mass or more and 0.45% by mass or less (B) 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-( (2-Thienylmethyl)acetamide and the mass ratio ((B) / (A)) of the content of component (B) to the content of component (A) is 0 .0014 or more and 0.02 or less, ​​​​Glycerin, propylene glycol, butylene glycol, and polyethylene glycol A liquid oral composition in a foam discharge container, wherein the content of one or more polyols (C) selected from the group consisting of less than 40% by mass is provided.

Effect of the Invention

[0009] According to the liquid oral composition in a foam discharge container of the present invention, not only does it provide a good refreshing feeling immediately after being discharged from the container and applied to the oral cavity in a foamed state, but also a long-lasting comfortable refreshing feeling can be felt even after the foam is spat out of the oral cavity.

Mode for Carrying Out the Invention

[0010] Hereinafter, the present invention will be described in detail. The liquid oral composition in a foam discharge container of the present invention contains menthol as component (A) in an amount of 0.0 1% by mass or more and 0.45% by mass or less. Such component (A) is a cooling agent that provides an excellent refreshing feeling and also provides a good fragrance. In the liquid oral composition in a foam discharge container of the present invention it is possible to continuously provide an excellent refreshing feeling from the time of application to the oral cavity until after being spat out of the oral cavity.

[0011] From the viewpoint of ensuring the expression of an excellent refreshing feeling, the content of component (A) in the liquid oral composition in a foam discharge container of the present invention is 0.01% by mass or more, preferably 0.07% by mass or more more preferably 0.15% by mass or more, and even more preferably 0.2% by mass or more. Further, from the viewpoint of avoiding a decrease in the refreshing feeling due to the expression of an unfavorable irritating sensation, the content of component (A) in the liquid oral composition in a foam discharge container of the present invention is 0.45% by mass or less. ​​​​% or less, preferably 0.4% by mass or less, more preferably 0.35% by mass or less. And the content of component (A) in the liquid oral composition contained in the foam discharge container of the present invention is 0.01% by mass or more and 0.45% by mass or less, preferably 0.07 to 0.4% by mass in the composition, preferably 0.15 to 0.35% by mass, more preferably 0.2 to 0.3 5% by mass.

[0012] The liquid oral composition contained in the foam discharge container of the present invention contains, as component (B), 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl)acet amide. By containing such component (B), while promoting the expression of the refreshing feeling by component (A), its persistence can be enhanced.

[0013] The content of component (B) promotes the expression of the refreshing feeling by component (A) and not only brings a good refreshing feeling immediately after being discharged from the container and applied to the oral cavity in a foamed state, but also expresses a comfortable refreshing feeling for a long time even after spitting out the foam outside the oral cavity. From this viewpoint, in the liquid oral composition contained in the foam discharge container of the present invention, it is preferably 0.0001% by mass or more, more preferably 0 .0002% by mass or more, still more preferably 0.0003% by mass or more. Also, from the viewpoint of continuously perceiving a refreshing feeling with an appropriate intensity, the content of component (B) in the liquid oral composition contained in the foam discharge container of the present invention is preferably 0.005% by mass or less, more preferably 0.004% by mass or less, still more preferably 0.003% by mass or less. Thus, the content of component (B) in the liquid oral composition contained in the foam discharge container of the present invention is preferably 0.0001 to 0.005% by mass, more preferably 0.0002 to 0.004% by mass ​ is by mass%, more preferably 0.0003 to 0.003% by mass.

[0014] In the liquid oral composition contained in the foam discharge container of the present invention, the mass ratio ((B) / (A)) of the content of component (B) to the content of component (A) not only brings a good refreshing feeling when discharged from the container and applied to the oral cavity in a foamy state, but also from the viewpoint of expressing a comfortable refreshing feeling for a long time even after spitting out the foam outside the oral cavity, it is 0.0014 or more, preferably 0.003 or more, more preferably 0.007 or more, still more preferably 0.008 or more and, from the viewpoint of continuously perceiving a refreshing feeling of appropriate strength, it is 0.02 or less, preferably 0.019 or less, more preferably 0.018 or less, still more preferably 0.017 or less. And, the mass ratio ((B) / (A)) of the content of component (B) to the content of component (A) (B) / (A)) is 0.0014 or more and 0.02 or less, preferably 0.003 to 0.019, more preferably 0.007 to 0.018, still more preferably 0 .008 to 0.017.

[0015] The liquid oral composition contained in the foam discharge container of the present invention has a content of one or more polyols (C) selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol of less than 40% by mass. That is, the liquid oral composition contained in the foam discharge container of the present invention may contain component (C), and in that case, the content of component (C) is less than 40% by mass, and it may also be the case where component (C) is not contained. Thus, by restricting the content of component (C), the sustainability of a comfortable refreshing feeling is maintained even after spitting out outside the oral cavity. It is possible to ensure a good refreshing feeling when applied to the oral cavity while maintaining a good .

[0016] In particular, when the foam is applied to the oral cavity after being discharged from the container, it gives off a refreshing feeling. From the viewpoint of the above, the case where component (C) is contained is preferable to the case where component (C) is not contained. It is nice. When component (C) is contained, such component (C) may be glycerin, propylene glycol, etc. One or more selected from the group consisting of glycol, butylene glycol, and polyethylene glycol It is preferable to use the polyols listed above as component (C). Among them, glycerin, proline, One or more polyols selected from pyrene glycol and butylene glycol It is preferable to use one or two selected from glycerin and propylene glycol. It is more preferable to use the above polyols.

[0017] In the case where the component (C) is contained, the content of the component (C) is determined so as to maintain a comfortable refreshing feeling. In order to maintain the durability of the composition, 40% water is added to the liquid oral composition in the foaming container of the present invention. %, preferably less than 38% by weight, and more preferably less than 36% by weight. It is preferably 5% by mass or more, more preferably 12% by mass or more, and more preferably is 22 mass % or more.

[0018] In addition, the mass ratio of the content of component (C) to the content of component (B) ((C) / (B)) is From the viewpoint of maintaining a suitable duration of refreshing feeling, it is preferably 0 or more, and more preferably is 8000 or more, more preferably 12000 or more, and preferably 80000 or less, more preferably 50,000 or less, and even more preferably 23,000 or less. exists. And the mass ratio ((C) / (B)) of the content of component (C) to the content of component (B) is preferably from 0 to 80000, more preferably from 8000 to 50000, and still more preferably from 12000 to 23000.

[0019] The liquid oral composition contained in the foam discharge container of the present invention contains an anionic surfactant (D). By containing such component (D), when the liquid oral composition contained in the foam discharge container of the present invention is discharged from the container, good foam can be formed, and the expression of a comfortable refreshing feeling can be promoted.

[0020] Examples of component (D) include alkyl sulfate esters such as lauryl sulfate and myristyl sulfate; alkyl phosphates such as lauryl phosphate; α-olefin sulfonates having 14 to 16 carbon atoms in the olefin; N-acyl glutamates such as N-lauroyl glutamate, N-myristoyl glutamate, N-palmitoyl glutamate, and N-cocoyl glutamate; N-methyl acyl taurates such as N-lauroyl methyl taurate and N-myristoyl methyl taurate; N-acyl taurates such as N-lauroyl taurate and N-myristoyl taurate; and acyl sarcosinates such as N-lauroyl sarcosinate and N-myristoyl sarcosinate. One or more selected therefrom may be mentioned. Among them, from the viewpoint of forming good foam and continuously providing a comfortable refreshing feeling when the liquid oral composition contained in the foam discharge container of the present invention is discharged from the container, one or more selected from alkyl sulfate esters, N-acyl glutamates, and N-methyl acyl taurates are preferred, alkyl sulfate esters are more preferred, and those having an alkyl group with 8 to 20 carbon atoms are even more preferred. In particular, from the viewpoint of forming good foam and continuously providing a comfortable refreshing feeling when the liquid oral composition contained in the foam discharge container of the present invention is discharged from the container, one or more selected from alkyl sulfate esters, N-acyl glutamates, and N-methyl acyl taurates are preferred, alkyl sulfate esters are more preferred, and those having an alkyl group with 8 to 20 carbon atoms are even more preferred. are preferred, and alkyl sulfate esters are more preferred, and those having an alkyl group with 8 to 20 carbon atoms​​​​​​​​​​ Alkyl sulfate salts are more preferred.

[0021] From the viewpoint of promoting the formation of good foam and maintaining the persistence of a comfortable refreshing feeling, the content of component (D) in the liquid oral composition in the foam discharge container of the present invention is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and still more preferably 0.2% by mass or more. Further, from the viewpoint of maintaining good dispersibility or solubility of each component and ensuring the expression of a comfortable refreshing feeling, the content of component (D) in the liquid oral composition in the foam discharge container of the present invention is preferably 1% by mass or less, more preferably 0.8% by mass or less, and still more preferably 0.6% by mass or less. And the content of component (D) in the liquid oral composition in the foam discharge container of the present invention is preferably 0.05 to 1% by mass, more preferably 0.1 to 0.8% by mass, and still more preferably 0.2 to 0.6% by mass. The liquid oral composition in the foam discharge container of the present invention can contain an amphoteric surfactant (E). By containing such component (E), it is possible to ensure the expression of a comfortable and lasting refreshing feeling.

[0022] As component (E), betaine acetates such as lauryldimethylaminoacetate betaine; imidazolinium betaines such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazolium betaine

[0023] ; alkyl sulfobetaines such as lauryl sulfobetaine and lauryl hydroxysulfobetaine; coconut oil fatty acid amidopropyl betaine and other coconut oil fatty acid amidoalkyl betaines; N-alkyl-1-hydroxyethylimidazoline betaine One or more types selected from long-chain alkyl imidazoline betaine salts such as sodium Among them, coconut oil fatty acid amide amide is the most effective for providing a long-lasting, comfortable and refreshing feeling. Preferably, the compound is one or more selected from the group consisting of alkyl betaines and alkyl sulfobetaines. More preferred is coconut oil fatty acid amido alkyl betaine, the alkyl group of which has 2 to 5 carbon atoms. More preferred are coconut oil fatty acid amido alkyl betaines, and coconut oil fatty acid amido propyl Betaine is even more preferred.

[0024] The content of component (E) is set to the range of the foam discharge capacity of the present invention from the viewpoint of maintaining a comfortable and lasting refreshing feeling. In the container-containing liquid oral composition, the content is preferably 0.1% by mass or more, more preferably 0. The content of component (E) is preferably 2% by mass or more, and more preferably 0.3% by mass or more. The content is determined from the viewpoint of maintaining good dispersibility or solubility of each component and ensuring the expression of a comfortable refreshing feeling. Therefore, the content of the foam-ejecting container-containing liquid oral composition of the present invention is preferably 7% by mass or less, More preferably, it is 4% by mass or less, and even more preferably, it is 2.5% by mass or less. The content of component (E) in the liquid oral composition in the foaming container of the present invention is preferably 0. .1 to 7 mass%, more preferably 0.2 to 4 mass%, and even more preferably 0. The content is 3 to 2.5 mass %.

[0025] The liquid oral composition in a foam-dispensing container of the present invention may contain water (F). The water in the component (F) in the description is purified water or water blended in the liquid oral composition in a foam dispenser. A liquid in a foam dispenser that contains not only on-exchange water but also the moisture contained in each of the ingredients. The total water content in the oral composition is the total water content in the oral composition. and when each component is well dispersed or dissolved and applied in the oral cavity in a foamy state and then spat out of the oral cavity, it is possible to ensure the expression of a comfortable refreshing feeling that lasts thereafter.

[0026] From the viewpoint of forming good foam and providing a comfortable refreshing feeling, the content of component (F) in the liquid oral composition contained in the foam discharge container of the present invention is preferably 35% by mass or more, more preferably 50% by mass or more, and still more preferably 60% by mass or more. Further, from the viewpoint of maintaining the sustainability of the refreshing feeling, the content of component (F) in the liquid oral composition contained in the foam discharge container of the present invention is preferably 98% by mass or less, more preferably 85% by mass or less, and still more preferably 75% by mass or less. And the content of component (F) in the liquid oral composition contained in the foam discharge container of the present invention is preferably 35 to 98% by mass, more preferably 50 to 85% by mass, and still more preferably 60 to 75% by mass.

[0027] The liquid oral composition contained in the foam discharge container of the present invention may contain a binder (G). By containing such a component (G), it is possible to ensure the expression of a comfortable and lasting refreshing feeling.

[0028] Examples of component (G) include alginic acid and its salts, carrageenan, xanthan gum, carboxymethyl cellulose and its salts, carboxyethyl cellulose and its salts, carboxymethyl hydroxyethyl cellulose and its salts, carboxymethyl hydroxypropyl cellulose and its salts, carboxymethyl ethyl cellulose and its salts, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, hydroxypropyl butyl cellulose, One or more selected from cellulose sulfate and cationized cellulose may be mentioned. Among them, , from the viewpoint of continuously providing a comfortable refreshing feeling, one or more selected from carboxymethyl cellulose and its salts, and one or more selected from hydroxyethyl cellulose are preferable.

[0029] From the viewpoint of maintaining the persistence of a comfortable refreshing feeling, the content of component (G) is preferably 0.05% by mass or more, more preferably 0 .1% by mass or more, still more preferably 0.15% by mass or more in the liquid oral composition contained in the foam discharge container of the present invention. Also, component (G) From the viewpoint of maintaining good dispersibility or solubility of each component and ensuring the expression of a comfortable refreshing feeling, the content of the component (G) is preferably 5% by mass or less in the liquid oral composition contained in the foam discharge container of the present invention , more preferably 4% by mass or less, still more preferably 3.5% by mass or less. Thus, the content of component (G) is preferably 0.05 to 5% by mass, more preferably 0.1 to 4% by mass, still more preferably 0.15 to 3.5% by mass in the liquid oral composition contained in the foam discharge container of the present invention. The liquid oral composition contained in the foam discharge container of the present invention preferably limits the content of the abrasive powder. Thereby, while ensuring good dischargeability from the container, it is possible to control the foam viscosity described later within a suitable range and maintain the persistence of the refreshing feeling.

[0030] Examples of such abrasive powders include light calcium carbonate, heavy calcium carbonate, zeolite, abrasive silica having an oil absorption of 50 to 150 mL / 100 g, dicalcium phosphate, tricalcium phosphate, insoluble sodium metaphosphate, aluminum hydroxide, magnesium phosphate . One or two or more selected from sodium, calcium pyrophosphate, magnesium carbonate, etc. are mentioned above. The oil absorption amount indicates the amount of oil that silica can carry, and the measurement method is based on JIS K5101-13-2 (established in 2004), and is specified by the amount of oil absorbed by the cooked sake.

[0031] From the viewpoint of ensuring good dischargeability from the container and effectively controlling the foam viscosity within a suitable range to ensure the expression of a comfortable refreshing feeling, the content of the abrasive powder in the liquid oral composition in the foam discharge container of the present invention is preferably 0.5% by mass or less, more preferably 0.4% by mass or less, even more preferably 0.3% by mass or less, or the liquid oral composition in the foam discharge container of the present invention preferably does not contain an abrasive powder.

[0032] It is preferable to limit the content of ethanol in the liquid oral composition in the foam discharge container of the present invention. Thereby, while ensuring good dischargeability from the container, it is possible to control the foam viscosity described later within a suitable range and maintain the persistence of the refreshing feeling. From the viewpoint of ensuring good dischargeability from the container and effectively controlling the foam viscosity within a suitable range to ensure the expression of a comfortable refreshing feeling, the content of ethanol in the liquid oral composition in the foam discharge container of the present invention is preferably 3% by mass or less, more preferably 2.5% by mass or less, even more preferably 2% by mass or less, still more preferably 1% by mass or less, or the liquid oral composition in the foam discharge container of the present invention preferably does not contain ethanol.

[0033] The liquid oral composition in the foam discharge container of the present invention, within a range that does not inhibit the effects of the present invention, the above​​​​​​​​​ In addition to the components, for example, sorbitol, erythritol, reduced palatinose, mannitol and other sugar alcohols; sweeteners such as saccharin or its salts; sodium carbonate, sodium hydrogen carbonate and other pH adjusters; preservatives such as isobutyl paraben, methyl salicylate; fluoride ; bactericides such as cetylpyridinium chloride, benzethonium chloride; fragrances other than component (A) and the like can be appropriately contained.

[0034] The foam viscosity of the liquid oral composition in the foam discharge container of the present invention at 25°C is controlled within an appropriate range, and from the viewpoint of providing a comfortable and lasting refreshing feeling, it is preferably 2000 mPa·s or more, more preferably 2500 mPa·s or more, still more preferably 3000 mPa·s or more, even more preferably 3500 mPa·s or more, even more preferably 4000 mPa·s or more, and preferably 7000 mPa·s or less more preferably 5800 mPa·s or less, still more preferably 5600 mPa·s or less. And the foam viscosity of the liquid oral composition in the foam discharge container of the present invention at 25°C is preferably 2000 mPa·s or more and 7000 mPa·s or less, more preferably 2500 to 5800 mPa·s, still more preferably 3000 to 5600 mPa·s and even more preferably 3500 to 5600 mPa·s, even more preferably 4000 to 5600 mPa·s. Note that the foam viscosity means the value measured at 25°C using a BH viscometer for the foam formed when the liquid oral composition in the foam discharge container of the present invention filled in the container is discharged from the discharge port to the outside.

[0035] The pH of the liquid oral composition in the foam discharge container of the present invention at 25°C is sufficient to provide a comfortable refreshing feeling. From the viewpoint of enabling comfortable enjoyment, it is preferably 5 to 11, more preferably 6 to 10.

[0036] The liquid oral composition in the foam discharge container of the present invention is prepared by mixing the above components (A), (B), and optionally component (C) in a predetermined component, and filling the resulting liquid oral composition as a content into a foam discharge container equipped with a discharge port. (A), (B), and optionally component (C) into a liquid oral composition. It is filled with a liquid oral composition as a content. When using the liquid oral composition in the foam discharge container of the present invention, the liquid oral composition as the content is directly discharged into the oral cavity from the discharge port provided in the foam discharge container, and the liquid oral composition passing through the discharge port is applied to the oral cavity in a foamed state.

[0037] The foam discharge container for filling the above liquid oral composition may be any container equipped with a discharge port, and may be a non-aerosol type container or an aerosol type container.

[0038] The non-aerosol type container is an atmospheric pressure container that does not require a propellant such as compressed gas. Examples of such containers include squeeze type containers and pump type containers. These containers preferably have one or more porous members provided with a mesh or a plurality of small holes in the flow path of the content from the container body to the discharge port, so that the foam viscosity is controlled within an appropriate range when the content passes through the discharge port, providing a comfortable and continuous refreshing feeling. More specifically, a foam discharge container filled with a liquid oral composition as a content has a porous member provided with a mesh of #50 to #400 in the flow path of the content from the container body to the discharge port. ​​​​​​​​​It is preferably formed with a solid member interposed therebetween, and more preferably a porous member provided with a mesh of #80 to #300, and still more preferably a porous member provided with a mesh of #100 to #250. It is more preferably formed with a porous member provided with a mesh of #100 to #250 interposed therebetween. It is still more preferably formed with such a porous member interposed therebetween.

[0039] A squeeze-type container is one that squeezes and deforms the body portion located in the deformable container body, thereby mixing the air pumped from the head space and the content while passing through the porous member as needed to form bubbles, and discharging such bubbles from the discharge port. Specifically, for example, the containers described in JP-A-7-215352, JP-U-58-174272, and JP-U-62-42787 can be used. By doing so, bubbles are formed by mixing the air and the content, and such bubbles are discharged from the discharge port. Specifically, for example, the containers described in JP-A-7-215352, JP-U-58-174272, and JP-U-62-42787 can be used. And the containers described in JP-U-62-42787 can be used.

[0040] A pump-type container is one that forms bubbles by mixing the air flowing in from the outside and the content while passing through the porous member as needed by pushing in the pump head provided in the foam discharger having a discharge port, and discharging such bubbles from the discharge port. Usually, it is provided with an air cylinder for allowing air to flow in from the outside and a liquid cylinder serving as a flow path for the content, and a mixing chamber for mixing the air and the content pumped by pushing in the pump head. Specifically, for example, the containers described in JP-A-7-315463, JP-A-8-230961, and JP-U-3-7963 can be used. By doing so, bubbles are formed by mixing the air and the content, and such bubbles are discharged from the discharge port. Specifically, for example, the containers described in JP-A-7-315463, JP-A-8-230961, and JP-U-3-7963 can be used. And the containers described in JP-U-3-7963 can be used. And a mixing chamber for mixing the air and the content pumped by pushing in the pump head. Specifically, for example, the containers described in JP-A-7-315463, JP-A-8-230961, and JP-U-3-7963 can be used. And the containers described in JP-U-3-7963 can be used.

[0041] An aerosol-type container is a container filled with a compressed gas as a propellant, and when the content is discharged from the discharge port, bubbles are formed while taking in the gas through the valve mechanism. The compressed gas to be used is preferably a gas containing 90% by mass or more of carbon dioxide gas. When the content is discharged from the discharge port, bubbles are formed while taking in the gas through the valve mechanism. The compressed gas to be used is preferably a gas containing 90% by mass or more of carbon dioxide gas. 。

[0042] Among them, from the viewpoints of easily interposing the porous member provided with the above #mesh, directly discharging the contents from the discharge port into the oral cavity, and excellent convenience and portability, a squeeze container is preferable.

Examples

Examples

[0043] Hereinafter, the present invention will be specifically described based on examples. Unless otherwise specified in the table, the content of each component is shown in mass%.

[0044] [Examples 1 to 7, Comparative Examples 1 to 5] According to Table 1, each liquid oral composition was prepared. Then, the liquid oral compositions other than Comparative Example 1 obtained were filled into a squeeze former container (F pump 8A, manufactured by Yoshino Kogyosho Co., Ltd.), and the contents were discharged from the discharge port and used as a foamed dosage form. Only the liquid oral composition obtained in Comparative Example 1 was used as a liquid dosage form as it was, and each measurement and evaluation was carried out according to the following method. The results are shown in Table 1. 《Measurement of foam viscosity》 Regarding each liquid oral composition filled in the above squeeze former container, the contents were discharged from the discharge port, and the foam viscosity (mPa·s) was measured at room temperature (25°C) using a BH viscometer (manufactured by Toki Sangyo Co., Ltd., H2 rotor, rotation speed: 5 rpm / 1 minute

[0045] 《Measurement of foam viscosity》 Regarding each liquid oral composition filled in the above squeeze former container, the contents were discharged from the discharge port, and the foam viscosity (mPa·s) was measured at room temperature (25°C) using a BH viscometer (manufactured by Toki Sangyo Co., Ltd., H2 rotor, rotation speed: 5 rpm / 1 minute interval). 《Evaluation of refreshing feeling》

[0046] 《Evaluation of refreshing feeling》 Regarding the time immediately after application into the oral cavity and 15 minutes after immediate discharge outside the oral cavity, the refreshing feeling was evaluated according to the following method. Note that the "refreshing feeling" refers to the feeling felt in the oral cavity from the liquid oral composition in the foam discharge container. Note that the "refreshing feeling" refers to the feeling felt in the oral cavity from the liquid oral composition in the foam discharge container. It means a degree of coolness and refreshing feeling that can be comfortably felt.

[0047] · Evaluation immediately after application into the oral cavity By professional panelists, for the refreshing feeling immediately after discharging the content of the liquid oral composition other than Comparative Example 1 from the above container into the oral cavity, the liquid oral composition of Comparative Example 1 was gargled in the oral cavity as it was, and the sensory evaluation was conducted according to the following criteria regarding the refreshing feeling.

[0048] 0: There is no refreshing feeling at all. 1: There is almost no refreshing feeling. 2: The refreshing feeling is weakly felt only. 3: There is a moderately refreshing feeling although it is slightly weak. 4: There is a moderately refreshing feeling.

[0049] · Evaluation at the time when 15 minutes have elapsed immediately after discharging outside the oral cavity After applying into the oral cavity, gargle for 30 seconds and discharge outside the oral cavity, then rinse once with water, and the sensory evaluation was similarly conducted according to the above criteria regarding the refreshing feeling at the time when 15 minutes have elapsed.

[0050]

Table 1

Claims

Claim 1 The following components (A) and (B): (A) Menthol: 0.01% by mass or more and 0.230% by mass or less (B) 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl)acetamide containing, and the mass ratio ((B) / (A)) of the content of component (B) to the content of component (A) is 0.0014 or more and 0.02 or less, the content of one or more polyols (C) selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol is 5% by mass or more and less than 40% by mass, and a liquid oral composition in a foam discharge container, wherein the mass ratio ((C) / (B)) of the content of component (C) to the content of component (B) is 12,000 or more and 50,000 or less. Claim 2 The liquid oral composition in a foam discharge container according to Claim 1, wherein the mass ratio ((B) / (A)) of the content of component (B) to the content of component (A) is 0.008 or more and 0.02 or less. Claim 3 The liquid oral composition in a foam discharge container according to Claim 1 or 2, wherein the content of the abrasive powder is 0.5% by mass or less, or the composition does not contain the abrasive powder. Claim 4 The liquid oral composition in a foam discharge container according to any one of Claims 1 to 3, wherein the content of ethanol is 3% by mass or less, or the composition does not contain ethanol. Claim 5 The liquid oral composition in a foam discharge container according to any one of Claims 1 to 4, wherein the pH at 25°C is 5 to 11. Claim 6 The liquid oral composition in a foam discharge container according to any one of Claims 1 to 5, filled in a non-aerosol type foam discharge container or an aerosol type foam discharge container. Claim 7 The liquid oral composition in a foam discharge container according to Claim 6, wherein the non-aerosol type foam discharge container is a container in which a porous member provided with a mesh of #50 to #400 is interposed in the flow path of the content from the container body to the discharge port.

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