Pulse Monitoring Method, Device, Equipment, and Storage Medium

Abstract

In the embodiments of the present application, a pulse monitoring method, an apparatus, a device and a storage medium are provided. The pulse monitoring method includes: outputting a first pulse train and a second pulse train to a target biological tissue; obtaining a feedback signal after the second pulse train is output to the target biological tissue; determining whether an end condition of the first pulse train is met according to the feedback signal; and when determining that the end condition of the first pulse train is met, stopping the output of the first pulse train, where the voltage of the second pulse train is lower than the voltage of the first pulse train, and the first pulse train is used to ablate the target biological tissue. In the embodiments of the present application, during the pulse ablation process, the ablation state of the target biological tissue can be determined according to the feedback signal, so as to monitor the ablation status of the target biological tissue during the pulse ablation process in real time, and guide the progress of the pulse ablation according to the ablation status of the biological tissue.

Description

Technical Field

[0001] This application relates to the field of medical device technologies, and in particular, to a pulse monitoring method, apparatus, device, and storage medium.

Background Art

[0002] Pulse ablation is a new biological tissue ablation technology that can be applied to various clinical diseases such as tumor ablation, cardiac tissue ablation, and proliferative tissue ablation.

[0003] Currently, there is no method for real-time monitoring and evaluation of the ablation effect on target biological tissue during the process of pulse ablation. As a result, it is impossible to guide the progress of ablation according to the state change of the target biological tissue.

Summary of the Invention

Problems to be Solved by the Invention

[0004] This application focuses on the drawbacks of the conventional method and provides a pulse monitoring method, apparatus, device, and storage medium to solve the technical problem existing in the prior art that the progress of pulse ablation cannot be guided according to the change state of biological tissue.

Means for Solving the Problems

[0005] In a first aspect, this application provides a pulse monitoring method, comprising: outputting a first pulse train and a second pulse train to a target biological tissue; acquiring a feedback signal after the second pulse train is output to the target biological tissue; determining whether the end condition of the first pulse train is satisfied based on the feedback signal; and stopping the output of the first pulse train when it is determined that the end condition of the first pulse train is satisfied. A pulse monitoring method is provided, where the voltage of the second pulse train is lower than that of the first pulse train, and the first pulse train is used to ablate the target biological tissue.

[0006] In one possible implementation, outputting the first pulse train and the second pulse train to the target biological tissue includes continuously and alternately outputting a first pulse train with a first designed number and a second pulse train with a second designed number to the target biological tissue.

[0007] In one possible implementation, the first pulse train includes at least one type of pulse, and the second pulse train includes at least one type of pulse.

[0008] In one possible implementation, the first pulse train includes nanosecond pulses or includes nanosecond pulses and microsecond pulses, and the second pulse train includes microsecond pulses.

[0009] In one possible implementation, the voltage of the first pulse train is greater than 500 volts and less than or equal to 15 kilovolts, and / or the voltage of the second pulse train is less than or equal to 500 volts.

[0010] In one possible implementation, obtaining the feedback signal after the second pulse train is output to the target biological tissue includes obtaining the real-time voltage and real-time current of the feedback circuit corresponding to the target biological tissue after the second pulse train is output to the target biological tissue. Based on the feedback signal, determining whether the end condition of the first pulse train is satisfied Based on the real-time voltage and real-time current of the feedback circuit, determining the real-time resistance value of the target biological tissue includes determining whether the real-time resistance value is less than the designed resistance value, or displaying the real-time resistance value and determining whether an end command for the first pulse train is received. When it is determined that the end condition of the first pulse train is satisfied, stopping the output of the first pulse train means When it is determined that the real-time resistance value is less than the designed resistance value, or when it is determined that an end command for the first pulse train is received, stopping the output of the first pulse train is included.

[0011] In one possible implementation, displaying the real-time resistance value means displaying the real-time resistance value curve, and displaying the real-time resistance value in correspondence with the biological index information of the target biological tissue, including at least one of The real-time resistance value curve includes at least two real-time resistance values in the designed time interval, and the biological index information includes at least one of heart rate, blood pressure, and blood oxygen concentration.

[0012] In one possible implementation, displaying the real-time resistance value and determining whether an end command for the first pulse train is received means when the biological index information of the target biological tissue becomes greater than the designed threshold value, issuing an alarm instruction, and when receiving the alarm information, outputting an end command for the first pulse train, including The alarm instruction includes emitting an alarm sound and / or outputting alarm information.

[0013] In a second aspect, the present application provides a pulse monitoring device, including a pulse output module for outputting a first pulse train and a second pulse train to a target biological tissue, an acquisition module for acquiring a feedback signal after the second pulse train is output to the target biological tissue, a processing module for determining whether the end condition of the first pulse train is satisfied based on the feedback signal, and stopping the output of the first pulse train when it is determined that the end condition of the first pulse train is satisfied, including A pulse monitoring device is provided, where the voltage of the second pulse train is lower than the voltage of the first pulse train, and the first pulse train is used to ablate a target biological tissue.

[0014] In a third aspect, the present application provides a pulse monitoring device, comprising a pulse generation circuit, a control unit, and a monitoring unit, wherein the control unit is communicatively connected to the pulse generation circuit and is configured to control the pulse generation circuit to output a first pulse train and a second pulse train to the target biological tissue, determine whether the end condition of the first pulse train is satisfied based on the feedback signal transferred from the monitoring unit, and output an end command for the first pulse train to the pulse generation circuit when it is determined that the end condition of the first pulse train is satisfied; the monitoring unit is communicatively connected to the control unit and is configured to obtain a feedback signal after the second pulse train is output to the target biological tissue and output the feedback signal to the control unit; the voltage of the first pulse train is higher than the voltage of the second pulse train, and the first pulse train is used to ablate a target biological tissue. A pulse monitoring device is provided.

[0015] In one possible implementation, the pulse generation circuit includes a first pulse generation circuit for outputting a first pulse train and a second pulse generation circuit for outputting a second pulse train. The first pulse generation circuit and the second pulse generation circuit are integrated on the same circuit board.

[0016] In one possible implementation, the first pulse generation circuit includes at least one stage of first pulse generation units electrically connected in sequence. The first pulse generation units are electrically connected to the control unit, turn on under the control of the control unit, and are used to output the first pulse train to the target biological tissue.

[0017] In one possible implementation, each stage of the at least one-stage first pulse generation unit includes a first capacitor, a first switching component, and a first diode. The first end of the first capacitor is electrically connected to the first end of the first switching component. The positive and negative electrodes of the first diode are electrically connected to the second end of the first capacitor and the second end of the first switching component, respectively. The control end of the first switching component is electrically connected to the control unit.

[0018] In one possible implementation, the first pulse generation circuit includes at least one second diode. The first end of the first capacitor of the first-stage first pulse generation circuit in the at least one-stage first pulse generation unit is electrically connected to the first power supply through at least one second diode.

[0019] In one possible implementation, the first pulse generation circuit further includes at least one third diode. The anode and cathode of the third diode are electrically connected to two adjacent first pulse generation units, respectively.

[0020] In one possible implementation, the second pulse generation circuit includes at least one-stage second pulse generation units that are electrically connected in sequence. The second pulse generation unit is electrically connected to the control unit and is used to output a second pulse train to the target biological tissue when it is turned on under the control of the control unit.

[0021] In one possible implementation, the second pulse generation unit includes a second capacitor, a second switching component, and a fourth diode. The first end of the second capacitor is electrically connected to the first end of the second switching component. The positive and negative electrodes of the fourth diode are electrically connected to the second end of the second capacitor and the second end of the second switching component, respectively. The control end of the second switching component is electrically connected to the control unit.

[0022] In one possible implementation, the pulse monitoring device further includes a display unit, which is communicatively connected to the control unit and is used to display at least one of the real-time resistance value, the real-time resistance value curve, and the biometric information.

[0023] In one possible implementation, the pulse monitoring device further includes an alarm unit, which is communicatively connected to the control unit and is used to issue an alarm instruction when the biometric information of the target biological tissue is greater than the designed threshold value.

[0024] In a fifth aspect, there is provided a computer-readable storage medium storing a computer program, where when the computer program is executed by a pulse monitoring device, it realizes the pulse monitoring method of the first aspect.

Advantages of the Invention

[0025] The beneficial technical effects brought by the technical solution provided in the embodiments of the present application at least include the following.

[0026] In the pulse monitoring method according to the embodiment of the present application, a first pulse train and a second pulse train are output to a target biological tissue, and based on the feedback signal after the second pulse train is output to the target biological tissue, it can be determined whether the end condition of the first pulse train is satisfied. That is, during the pulse ablation process, the ablation state of the target biological tissue can be determined based on the feedback signal, and the change of the target biological tissue during the pulse ablation process can be monitored in real time. When it is determined that the end condition of the first pulse train is satisfied, the output of the first pulse train is stopped. That is, the embodiment of the present application can guide the progress of pulse ablation according to the change situation of the biological tissue, and after it is determined that the effect of pulse ablation is achieved, by stopping the output of the first pulse train for biological tissue ablation, the guidance of the progress of pulse ablation according to the ablation situation of the target biological tissue is realized.

[0027] The accompanying aspects and advantages of the present application are given in part in the following description, and these will become apparent from the following description or will be understood through the implementation of the present application.

[0028] The above-mentioned and / or additional aspects and advantages in the present application will become apparent and easy to understand from the following description of the embodiments in conjunction with the drawings.

Brief Description of the Drawings

[0029]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Embodiment for Carrying Out the Invention

[0030] The present application will be described in detail below. Examples of the embodiments are shown in the accompanying drawings, and throughout the drawings, parts having the same or similar parts or the same or similar functions are represented by the same or similar reference numerals. Also, a detailed description of known technologies is omitted when it is unnecessary for showing the features of the present application. Hereinafter, the embodiments described with reference to the accompanying drawings are exemplary and are only used for the interpretation of the present application and should not be construed as a limitation to the interpretation of the present application.

[0031] As can be understood by those skilled in the art, unless otherwise specifically defined, all terms (including technical terms and scientific terms) used herein have the same meaning as the ordinary understanding of a general technician in the field to which the present application belongs. Furthermore, terms defined as in a general dictionary should be interpreted in a meaning consistent with their meaning in the context of the prior art and should not be interpreted in an idealized or overly formal meaning unless specifically defined here.

[0032] Unless otherwise expressly stated, those skilled in the art should understand that the singular forms "one", "a", "the", and "said" used herein can also include the plural forms. Further, the expression "comprising" in the specification of this application refers to the presence of the described features, integers, steps, operations, elements, and / or components, but is not to be construed as excluding the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof. When an element is said to be "connected" or "coupled", it can be directly connected or coupled to other elements, and it is also possible that intermediate elements exist. Also, the "connection" or "coupling" used herein may include wireless connection or wireless coupling. And the expression "and / or" used herein includes all units, any one unit, or all combinations of at least one of the listed and related items to each other.

[0033] Through research, the inventor of this application found that in the conventional pulse ablation process, real-time monitoring and evaluation of the effect of pulse ablation were not considered, so the change situation of biological tissue during the ablation process could not be obtained. As a result, there was no basis for accurately guiding the progress of pulse ablation.

[0034] Furthermore, the inventor of this application also recognized that the conventional pulse ablation technology mainly focuses on the localization of lesions, and no method or technology for real-time monitoring of the pulse ablation process has been disclosed yet. Moreover, in the conventional pulse generator, in order to realize the monitoring function, it is necessary to separately equip other monitoring devices or independent modules. Therefore, further exploration is needed to realize the monitoring of pulse ablation.

[0035] The pulse monitoring method, device, equipment, and storage medium provided by this application aim to solve the above technical problems of the prior art.

[0036] The following will describe in detail the technical solution of this application and how the solution solves the above-mentioned technical problems through specific embodiments.

[0037] In the embodiments of this application, a pulse monitoring device 10 is provided. As shown in FIG. 1, the pulse monitoring device 10 includes a pulse generation circuit 100, a control unit 200, and a monitoring unit 300.

[0038] The control unit 200 is communicatively connected to the pulse generation circuit 100, and is used to control the pulse generation circuit 100 to output a first pulse train and a second pulse train to the target biological tissue, determine whether the end condition of the first pulse train is satisfied based on the feedback signal transferred from the monitoring unit 300, and output an end command for the first pulse train to the pulse generation circuit 100 when it is determined that the end condition of the first pulse train is satisfied. The monitoring unit 300 is communicatively connected to the control unit 200, and is used to obtain the feedback signal after the second pulse train is output to the target biological tissue and output the feedback signal to the control unit 200. The voltage of the first pulse train is higher than that of the second pulse train, and the first pulse train is used to ablate the target biological tissue.

[0039] The pulse generation circuit 100 of the pulse monitoring device 10 according to the embodiments of this application can output a first pulse train and a second pulse train to the target biological tissue under the control of the control unit 200. The control unit 200 determines whether the end condition of the first pulse train is satisfied based on the feedback signal from the monitoring unit 300. That is, during the process of pulse ablation, the control unit 200 checks the ablation status of the target biological tissue based on the feedback signal and can monitor the ablation status of the target biological tissue in real time during the ablation process.

[0040] The control unit 200 according to the embodiment of the present application can guide the progress of pulse ablation according to the change status of biological tissue. After determining that the effect of pulse ablation has been achieved, by outputting an end command for the first pulse train, the control unit 200 controls the pulse generation circuit 100 to stop outputting the first pulse train for biological tissue ablation, so as to realize guiding the progress of pulse ablation according to the change status of biological tissue.

[0041] The pulse monitoring device 10 according to the embodiment of the present application integrates two functions of pulse ablation and monitoring in one device, eliminating the need to separately equip other monitoring devices or independent modules, and is convenient to use and operate.

[0042] Optionally, the target biological tissue includes the part of the human body to be ablated.

[0043] Optionally, as shown in FIG. 2, the pulse monitoring device 10 further includes a display unit 400 for displaying the real-time resistance value, which is communicatively connected to the control unit 200.

[0044] Optionally, the display unit 400 is further used to display a real-time resistance value curve including at least two of the real-time resistance values in the designed time interval, or to display the real-time resistance value corresponding to the biological index information of the target biological tissue. The biological index information includes at least one of heart rate, blood pressure, and blood oxygen concentration.

[0045] Optionally, the display unit 400 may also be a display screen for displaying the real-time resistance value, the real-time resistance value curve, or the biological index information.

[0046] Optionally, as shown in FIG. 2, the pulse monitoring device 10 further includes an alarm unit 500, which is communicatively connected to the control unit 200 and is used to issue an alarm instruction when the biometric tissue becomes larger than the designed threshold value. The alarm instruction includes emitting an alarm sound and / or outputting alarm information to the control unit 200. When receiving the alarm information, the control unit 200 is used to output an end command for the first pulse train.

[0047] In some embodiments, as shown in FIG. 3, the pulse generation circuit 100 includes a first pulse generation circuit 110 for outputting a first pulse train and a second pulse generation circuit 120 for outputting a second pulse train.

[0048] The first pulse generation circuit 110 and the second pulse generation circuit 120 are integrated on the same circuit board.

[0049] In the embodiments of the present application, by integrating the first pulse generation circuit 110 and the second pulse generation circuit 120 on the same circuit board, it is possible to output the first pulse train and the second pulse train from one circuit board, thus achieving both the ablation function and the monitoring function.

[0050] In some embodiments, as shown in FIG. 3, the first pulse generation circuit 100 includes at least one stage of first pulse generation units 111 connected electrically in sequence. The first pulse generation unit 111 is electrically connected to the control unit 200, is turned on under the control of the control unit 200, and is used to output the first pulse train to the target biological tissue.

[0051] Optionally, as shown in FIG. 3, each stage of the first pulse generation unit 111 includes a first capacitor, a first switch component, and a first diode. The first end of the first capacitor is electrically connected to the first end of the first switch component, and the positive and negative electrodes of the first diode are electrically connected to the second end of the first capacitor and the second end of the first switch component, respectively. The control end of the first switch component is electrically connected to the control unit 200.

[0052] Optionally, when the first pulse generation circuit 110 discharges, the control unit 200 controls the first switch component of the first pulse generation unit 111 to turn on.

[0053] Optionally, as shown in FIG. 3, the first pulse generation circuit 110 includes at least one second diode. The first end of the first capacitor of the first pulse generation circuit 110 in the first stage is electrically connected to the first power supply UH through at least one second diode. The positive electrode of the second diode is electrically connected to the first power supply UH, and the negative electrode of the second diode is electrically connected to the first end of the first capacitor of the first pulse generation circuit 110 in the first stage.

[0054] Optionally, as shown in FIG. 3, the first pulse generation circuit 110 further includes at least one third diode, and the anode and cathode of the third diode are electrically connected to two adjacent first pulse generation units 111, respectively. The anode and cathode of the third diode are electrically connected to the first end of the first switch component in the previous stage and the first end of the first capacitor in the next stage, respectively.

[0055] In some embodiments, as shown in FIG. 3, the second pulse generation circuit 120 includes at least one stage of second pulse generation units 121 connected electrically in sequence. The second pulse generation unit 121 is electrically connected to the control unit 200, turns on under the control of the control unit 200, and is used to output a second pulse train to the target biological tissue.

[0056] Optionally, as shown in FIG. 3, the second pulse generation unit 121 includes a second capacitor, a second switch component, and a fourth diode. The first end of the second capacitor is electrically connected to the first end of the second switch component. The positive and negative electrodes of the fourth diode are electrically connected to the second end of the second capacitor and the second end of the second switch component, respectively. The control end of the second switch component is electrically connected to the control unit 200.

[0057] Optionally, when the second pulse generation circuit 120 discharges, the control unit 200 controls the second switch device of the second pulse generation unit 121 to turn on.

[0058] Optionally, the end command of the first pulse train includes a command output from the control unit 200 to control the second switch component to turn off.

[0059] Optionally, as shown in FIG. 3, the second pulse generation circuit 120 includes at least one fifth diode. The positive electrode of the fifth diode is electrically connected to the second power supply UL. The negative electrode of the fifth diode is electrically connected to the first end of the second capacitor of the second pulse generation unit 121 in the first stage.

[0060] Optionally, as shown in FIG. 3, the second pulse generation circuit 120 includes at least one sixth diode. The positive and negative electrodes of the sixth diode are electrically connected to adjacent second pulse generation units 121, respectively. The positive and negative electrodes of the sixth diode are electrically connected to the first end of the second switch component in the previous stage and the first end of the second capacitor in the next stage, respectively.

[0061] Optionally, as shown in FIG. 3, the pulse monitoring device 10 includes a first capacitor discharge relay 112 and a second capacitor discharge relay 122. The first ends of both the first capacitor discharge relay 112 and the second capacitor discharge relay 122 are grounded, and the second ends of the first capacitor discharge relay 112 and the second capacitor discharge relay 122 are electrically connected to the last-stage first pulse generation unit 111 and the last-stage second pulse generation unit 121, respectively.

[0062] In the special case where the first capacitor discharge relay 112 and the second capacitor discharge relay 122 need to discharge quickly, the discharge of the capacitor is artificially controlled to make the discharge of the capacitor in the pulse generation circuit 100 more complete and rapid.

[0063] Optionally, as shown in FIG. 3, the pulse monitoring device 10 further includes a first output relay 150, a second output relay 160, and a foot switch 170. The first end of the first output relay 150 is electrically connected to both the first pulse generation circuit 110 and the second pulse generation circuit 120. The second end of the first output relay 150 is electrically connected to the first end of the second output relay 160. The second end of the second output relay 160 is electrically connected to the load RLoad, and the load RLoad is grounded. The foot switch 170 is electrically connected to the third end of the first output relay 150 and is used to control to form a discharge circuit between the load RLoad, the first output relay 150, and the first pulse generation circuit 110 or the second pulse generation circuit 120.

[0064] The settings of the first output relay 150, the second output relay 160, and the foot switch 170 are used to turn off the supply path where the load RLoad (i.e., the human body part) is located, thereby realizing an improvement in safety. The second output relay 160 can be selected as a 12-channel relay. The load RLoad corresponds to the equivalent load of the target biological tissue.

[0065] Optionally, as shown in FIG. 3, the monitoring unit 300 includes a first Pearson coil 310, a second Pearson coil 320, and a first resistor R1. The first end of the first Pearson coil 310 is connected to the first resistor R1, and the first resistor R1 is grounded. The second end of the first Pearson coil 310 is connected to the first end of the second Pearson coil 320, and the second end of the second Pearson coil 320 is electrically connected to both the first pulse generation circuit 110 and the second pulse generation circuit 120. The feedback circuit is a circuit formed by the second pulse generation circuit 120 and the load RLoad.

[0066] Optionally, the first Pearson coil 310 has two roles. The first is to provide a path for the pulses generated when the discharge circuit does not discharge, and the second is that because the resistance value of the coil is approximately 10 - 100 kΩ (kiloohm), it can be used for real-time voltage monitoring. And the second Pearson coil 320 is used for current measurement.

[0067] Optionally, when the second pulse generation circuit 120 and the load RLoad are electrically connected to form a feedback circuit, the first Pearson coil 310 and the second Pearson coil 320 are collected as two sampling points for collecting the real-time voltage and real-time current on the feedback circuit.

[0068] As an example, as shown in FIG. 3, which is provided as a schematic diagram showing that the pulse generation circuit 100, the power supply, the load RLoad, and the monitoring unit are electrically connected, the power supply circuit where the first power supply UH is located is a high-voltage nanosecond pulse generation circuit, and the power supply circuit where the second power supply UL is located is a low-voltage microsecond pulse generation circuit. As the feedback circuit, the power supply circuit where the second power supply UL is located includes a two-stage second pulse generation unit 121, and the width of the output voltage is 0 to 500 V (volt). The power supply circuit where the first power supply UH is located may include a twenty-stage first pulse generation unit 111, which can generate high-voltage nanosecond pulses of 0 to 15 kV (kilovolt).

[0069] Optionally, in this embodiment, in the low-voltage microsecond pulse generation circuit, the capacitor C1, the switch component T1, and the diode D1 constitute one second pulse generation unit 121, the capacitor C2, the switch component T2, and the diode D2 constitute one second pulse generation unit 121, the diode D7 functions as the sixth diode, and the diode D6 functions as the fifth diode.

[0070] Optionally, in this embodiment, in the high-voltage nanosecond pulse generation circuit, the capacitor C3, the switch component T3, and the diode D3 constitute one first pulse generation unit 111, the capacitor C4, the switch component T4, and the diode D4 constitute one first pulse generation unit 111, and the capacitor Cn, the switch component Tn, and the diode Dn constitute one first pulse generation unit 111. The diodes D8, D9, D10, D11, and D12 are all second diodes, the diodes D9, D10, D11, and D12 are connected in series in sequence, and the diode D13 is the third diode.

[0071] Optionally, the switch component used in the low-voltage microsecond pulse generation circuit is a MOSFET (Metal-Oxide-Semiconductor Field-Effect Transistor), and the switch component used in the high-voltage nanosecond pulse generation circuit is an IGBT (Insulated Gate Bipolar Transistor).

[0072] Based on the same inventive concept, an embodiment of the present application provides a pulse monitoring method. As shown in FIG. 3, the pulse monitoring method includes steps S401 to S404.

[0073] S401. Output a first pulse train and a second pulse train to the target biological tissue. The voltage of the second pulse train is lower than that of the first pulse train, and the first pulse train is used to ablate the target biological tissue.

[0074] In the embodiments of the present application, the second pulse train output to the target biological tissue reflects the state of the target biological tissue in real time and is used to monitor the ablation status of the target biological tissue during the pulse ablation process. As a result, based on the ablation status of the target biological tissue, the progress of the pulse ablation can be guided.

[0075] Optionally, the pulse generation circuit 100 outputs a first pulse train and a second pulse train to the target biological tissue.

[0076] In some embodiments, outputting a first pulse train and a second pulse train to the target biological tissue includes alternately and continuously outputting a first pulse train with a first design number and a second pulse train with a second design number to the target biological tissue.

[0077] Optionally, the pulse generation circuit 100 alternately and continuously outputs a first pulse train with a first design number and a second pulse train with a second design number to the target biological tissue.

[0078] Optionally, the first design number and the second design number may be the same or different. For example, when both the first design number and the second design number are 1, one first pulse train and one second pulse train are alternately output. Also, for example, when the first design number is 3 and the second design number is 1, it repeats such that after 3 first pulse trains are output, 1 second pulse train is output.

[0079] In this embodiment, the first pulse train and the second pulse train can be alternately output. As a result, since the second pulse train is output in each cycle, the monitoring of the ablation status of the target biological tissue is performed in real time, and thus, an immediate response can be made to changes in the target biological tissue.

[0080] In some embodiments, the first pulse train includes at least one type of pulse, and the second pulse train includes at least one type of pulse.

[0081] Optionally, the first pulse train includes only one type of pulse, the second pulse train includes only one type of pulse, and the voltage of the pulse in the first pulse train is higher than the voltage of the pulse in the second pulse train.

[0082] In some embodiments, the first pulse train includes nanosecond pulses, or includes nanosecond pulses and microsecond pulses, and the second pulse train includes microsecond pulses.

[0083] Optionally, when the first pulse train includes nanosecond pulses and microsecond pulses, the microsecond pulses are also used for ablation of the target biological tissue.

[0084] In some embodiments, the voltage of the first pulse train is greater than 500 volts and less than or equal to 15 kilovolts, and / or the voltage of the second pulse train is less than or equal to 500 volts.

[0085] As an example, as shown in FIG. 5, the horizontal axis represents time and the vertical axis represents the voltage of the pulse. The first pulse train is a high-voltage nanosecond pulse, and the second pulse train is a low-voltage microsecond pulse. One high-voltage nanosecond pulse and one low-voltage microsecond pulse are output alternately. The high-voltage nanosecond pulse is used to ablate the target biological tissue, and the low-voltage microsecond pulse is used to monitor the ablation status of the target biological tissue.

[0086] Optionally, the current range of the high-voltage nanosecond pulse is 0 to 300 A (ampere), and the pulse duration is 200 to 1000 nanoseconds. The current range of the low-voltage microsecond pulse is 0 to 100 A (ampere), and the pulse duration is 10 to 300 microseconds.

[0087] Step 402: Obtain the feedback signal after the second pulse train is output to the target biological tissue.

[0088] Optionally, the monitoring unit 300 obtains the feedback signal after the second pulse train is output to the target biological tissue and outputs the feedback signal to the control unit 200.

[0089] In some embodiments, obtaining the feedback signal after the second pulse train is output to the target biological tissue includes obtaining the real-time voltage and real-time current of the feedback circuit corresponding to the target biological tissue after the second pulse train is output to the target biological tissue.

[0090] Step 403: Determine whether the end condition of the first pulse train is satisfied based on the feedback signal.

[0091] Optionally, the monitoring unit 300 outputs the feedback signal to the control unit 200, and the control unit 200 determines whether the end condition of the first pulse train is satisfied based on the feedback signal.

[0092] The inventors of the present application have discovered through research that in biological tissues, cells are arranged neatly and densely, and a single cell can be regarded as a basic constituent unit with a certain resistance. After ablation by high-voltage nanosecond pulses, some cells rupture, and thus the change in the resistance value between the two electrodes is inevitable. Generally, the higher the degree of ablation of the tissue, the smaller the resistance value. Therefore, to a certain extent, the resistance can reflect the degree of ablation of the tissue.

[0093] In view of the above considerations, in some embodiments, determining whether the end condition of the first pulse train is satisfied based on the feedback signal includes determining the real-time resistance value of the target biological tissue based on the real-time voltage and real-time current of the feedback circuit determining whether the real-time resistance value is less than the designed resistance value, or displaying the real-time resistance value and determining whether an end command for the first pulse train has been received.

[0094] In some embodiments, determining whether the end condition of the first pulse train is satisfied based on the feedback signal is The control unit 200 determines the real-time resistance value of the target biological tissue based on the real-time voltage and real-time current of the feedback circuit, The control unit 200 determines whether the real-time resistance value is less than the designed resistance value, or the display unit 400 displays the real-time resistance value, and the control unit 200 determines whether an end command for the first pulse train has been received.

[0095] Optionally, the designed resistance value is a value obtained by medical personnel from an ablation experiment. When the real-time resistance value is smaller than the designed resistance value, it is determined that the desired ablation has been achieved.

[0096] Optionally, the calculation process of the real-time resistance value is performed as shown in Equation 1 below. In JPEG0007713756000001.jpg, 21170Uin is the real-time voltage of the input pulse, Im is the real-time current, and Z is the calculated real-time resistance value. The calculated real-time resistance value corresponds to the equivalent resistance value of the target biological tissue and can accurately reflect the ablation situation of the target biological tissue.

[0097] In some embodiments, displaying the real-time resistance value is including displaying a real-time resistance value curve, and the real-time resistance value curve includes at least two real-time resistance values in the designed time interval.

[0098] Optionally, displaying the real-time resistance value is The display unit 400 includes displaying a real-time resistance value curve, which includes at least two real-time resistance values in the designed time interval.

[0099] Optionally, by displaying the real-time resistance value, it is more convenient for the doctor to determine whether to stop the output of the first pulse train for the application based on the real-time resistance value. In actual applications, the doctor can consider the current situation of the biological tissue and decide whether to continue or stop the application based on experience. The display of the real-time resistance value closes the entire medical process into a closed loop, provides a basis for the doctor's decision-making, and contributes to the improvement of the application effect.

[0100] Optionally, displaying the real-time resistance value includes displaying the real-time resistance value corresponding to the biological index information of the target biological tissue, and the biological index information includes at least one of heart rate, blood pressure, and blood oxygen concentration.

[0101] Optionally, displaying the real-time resistance value means that the display unit 400 displays the real-time resistance value corresponding to the biological index information of the target biological tissue, and the biological index information includes at least one of heart rate, blood pressure, and blood oxygen concentration.

[0102] Optionally, determining whether to display the real-time resistance value and receive an end command for the first pulse train includes issuing an alarm instruction when the biometric information is greater than the designed threshold value, and when the control unit 200 receives the alarm information, outputting an end command for the first pulse train. The alarm instruction includes issuing an alarm sound and / or outputting alarm information.

[0103] Optionally, determining whether to display the real-time resistance value and receive an end command for the first pulse train includes the alarm unit 500 issuing an alarm instruction when the biometric information is greater than the designed threshold value.

[0104] In the embodiments of the present application, when performing ablation on a target biological tissue of a patient, the biological characteristic information of the patient can be monitored simultaneously to avoid the patient being at risk during the ablation process, and further ensure the effect of ablation.

[0105] S404. When it is determined that the end condition of the first pulse train is satisfied, stop the output of the first pulse train.

[0106] Optionally, when the control unit 200 determines that the end condition of the first pulse train is satisfied, stopping the output of the first pulse train includes stopping the output of the first pulse train when it is determined that the real-time resistance value is less than the designed resistance value, or stopping the output of the first pulse train when it is determined that an end command for the first pulse train is received.

[0107] Optionally, when it is determined that the end condition of the first pulse train is satisfied, stopping the output of the first pulse train When the control unit 200 determines that the real-time resistance value is less than the designed resistance value, output an end command for the first pulse train to the pulse generation circuit 100 to control the pulse generation circuit 100 to stop the output of the first pulse train, or when the control unit 200 determines that an end command for the first pulse train is received, control the pulse generation circuit 100 to stop the output of the first pulse train.

[0108] Optionally, when it is determined that the real-time resistance value is greater than or equal to the designed resistance value, continue to output the first pulse train for ablation until the real-time resistance value becomes less than the designed resistance value. When it is determined that the real-time resistance value is less than the designed resistance value, the desired ablation has been achieved, and the first pulse train can be continuously output to perform ablation on the target biological tissue.

[0109] Based on the above technical solution, in the embodiments of the present application, the target biological tissue is regarded as an electrical network, a second pulse train is input into the target biological tissue, and the response of the target biological tissue to this stimulus can be measured by a feedback circuit. Based on the stimulus and the response, the equivalent real-time resistance value of the biological tissue can be determined, and the effect of pulse ablation can be evaluated based on the numerical value of the real-time resistance value.

[0110] In the embodiments of the present application, the real-time resistance value of the target biological tissue is calculated based on the real-time voltage and the real-time current, and whether a single pulse ablation of the real-time resistance value has achieved the desired degree of tissue ablation can be used to guide the progress of pulse ablation by medical personnel.

[0111] Based on the same inventive concept, in the embodiments of the present application, a pulse monitoring device is provided. As shown in FIG. 6, the pulse monitoring device 60 includes a pulse output module 610, an acquisition module 620, and a processing module 630.

[0112] The pulse output module 610 is used to output a first pulse train and a second pulse train to the target biological tissue. The voltage of the second pulse train is lower than the voltage of the first pulse train, and the first pulse train is used to ablate the target biological tissue.

[0113] The acquisition module 620 is used to acquire the feedback signal after the second pulse train is output to the target biological tissue.

[0114] The processing module 630 is used to determine whether the end condition of the first pulse train is satisfied based on the feedback signal. When it is determined that the end condition of the first pulse train is satisfied, the output of the first pulse train is stopped.

[0115] Optionally, the pulse output module 610 is further used to alternately and continuously output a first pulse train with a first design number and a second pulse train with a second design number to the target biological tissue.

[0116] Optionally, the acquisition module 620 is further used to acquire the real-time voltage and real-time current of the feedback circuit corresponding to the target biological tissue after the second pulse train is output to the target biological tissue.

[0117] Optionally, the processing module 630 is further used to determine the real-time resistance value of the target biological tissue based on the real-time voltage and real-time current of the feedback circuit, and to determine whether the real-time resistance value is less than the designed resistance value, or to display the real-time resistance value and determine whether an end command for the first pulse train has been received.

[0118] The processing module 630 is further used to display the real-time resistance value curve, or to display the real-time resistance value corresponding to the biological index information of the target biological tissue. The real-time resistance value curve includes at least two real-time resistance values in the designed time interval, and the biological index information includes at least one of heart rate, blood pressure, and blood oxygen concentration.

[0119] Optionally, the processing module 630 is further used to stop the output of the first pulse train when it is determined that the real-time resistance value is less than the designed resistance value, or to stop the output of the first pulse train when it is determined that an end command for the first pulse train has been received.

[0120] Based on the same inventive concept, an embodiment of the present application provides a computer-readable storage medium storing a computer program, and when the computer program is executed by the pulse monitoring device 10, the computer-readable storage medium realizes the pulse monitoring method according to any embodiment of the present application.

[0121] The computer-readable medium according to an embodiment of the present application may be a computer-readable signal medium, a computer-readable storage medium, or any combination of the foregoing. The computer-readable storage medium may be an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing, but is not limited thereto. More specific examples of the computer-readable storage medium include an electrical connection having one or more wires, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing, but is not limited thereto.

[0122] The computer-readable medium according to an embodiment of the present application may be any tangible medium that contains or stores a program. The program may be used by or in combination with an instruction execution system, apparatus, or device. On the other hand, in the present application, the computer-readable signal medium may include a data signal carrying a computer-readable program code that is propagated in a baseband or as part of a carrier. Such a propagated data signal can take various forms including, but not limited to, an electromagnetic signal, an optical signal, or any suitable combination of the foregoing. The computer-readable signal medium may be any computer-readable medium other than the computer-readable storage medium. The computer-readable signal medium can transmit, propagate, or transfer a program used by or in combination with an instruction execution system, apparatus, or device. The program code included in the computer-readable medium can be transmitted using any appropriate medium including, but not limited to, wires, an optical fiber cable, RF (radio frequency), or any suitable combination of the foregoing.

[0123] Applying the embodiments of the present application can achieve at least the following effects (1) to (6).

[0124] (1) The pulse monitoring method according to the embodiment of the present invention can determine the ablation state of the target biological tissue based on the feedback signal during the pulse ablation process, and can monitor the ablation state of the target biological tissue in real time during the pulse ablation process. When it is determined that the end condition of the first pulse train is satisfied, the output of the first pulse train is stopped. That is, the embodiment of the present application can guide the progress of pulse ablation according to the change situation of the biological tissue, and after it is determined that the effect of pulse ablation is achieved, the output of the first pulse train for biological tissue ablation is stopped, thereby realizing the guidance of the progress of pulse ablation according to the change situation of the target biological tissue.

[0125] (2) In the embodiment of the present application, the first pulse train and the second pulse train can be output alternately, so that the second pulse train is output in each cycle, and thus the monitoring of the ablation state of the target biological tissue is performed in real time, and therefore, it can respond immediately to the change of the target biological tissue.

[0126] (3) In the embodiment of the present application, when performing ablation of the target biological tissue on a patient, the biological characteristic information of the patient is monitored simultaneously to avoid the patient being at risk during the ablation process, and further ensure the effect of ablation.

[0127] (4) In the embodiment of the present application, the real-time resistance value of the target biological tissue is obtained based on the real-time voltage and real-time current, and based on whether a single pulse ablation of the real-time resistance value has reached the desired tissue ablation degree, the progress of pulse ablation by medical staff can be guided.

[0128] (5) In the embodiments of the present application, the first pulse generation circuit 110 and the second pulse generation circuit 120 are integrated on the same circuit board, so that a first pulse train and a second pulse train can be output from one circuit board, enabling both the ablation function and the monitoring function.

[0129] (6) The pulse monitoring device 10 according to the embodiments of the present application integrates two functions, namely pulse ablation and monitoring, into one device, eliminating the need to separately equip other monitoring devices or independent modules, and is convenient to use and operate.

[0130] As those skilled in the art can understand, various operations, methods, process steps, treatments, and solutions already discussed in the present application can be interchanged, changed, combined, and deleted. Furthermore, other steps, treatments, and solutions during the various operations, methods, and processes already discussed in the present application can also be interchanged, changed, rearranged, decomposed, combined, or deleted. Additionally, in the prior art, those similar to the various operations, methods, process steps, treatments, and solutions disclosed in the present application can also be interchanged, changed, rearranged, decomposed, combined, or deleted.

[0131] The terms "first" and "second" are used only for descriptive purposes and should not be construed as indicating or suggesting relative importance or indicating the quantity of the indicated technical features. Therefore, the features limited by "first" and "second" can explicitly or implicitly indicate the inclusion of one or more of those features. In the description of the present application, unless otherwise explicitly stated, "a plurality" means two or more.

[0132] In the flowchart of the drawings, each step is displayed in order as indicated by the arrows. However, these steps are not necessarily executed in the order indicated by the arrows. Unless there is a clear explanation in the text, there is no strict order for the execution of these steps, so they can be executed in other orders. Also, at least some of the steps in the flowchart of the drawings include multiple sub-steps or stages, and these are not necessarily executed simultaneously and may be executed at different times. The execution order is not necessarily sequential either, and may be executed alternately or in alternation with at least some of other steps, sub-steps of other steps, or stages.

[0133] What has been described above is only some embodiments of the present application. Those skilled in the art can make further improvements and refinements without departing from the principle of the present application, and these improvements and refinements should also be regarded as within the protection scope of the present application.

Explanation of Reference Numerals

[0134] 10 Pulse monitoring device 100 Pulse generation circuit 110 First pulse generation circuit 111 First pulse generation unit 120 Second pulse generation circuit 121 Second pulse generation unit 200 Control unit 300 Monitoring unit 112 First capacitor discharge relay 122 Second capacitor discharge relay 310 First Pearson coil 320 Second Pearson coil 150 First output relay 160 Second output relay 170 Foot switch RLoad Load UH First power supply UL Second power supply 400 Display unit 500 Alarm unit

Claims

1. A pulse monitoring device, comprising a pulse generation circuit, a control unit, and a monitoring unit, wherein the control unit is communicatively connected to the pulse generation circuit and is configured to control the pulse generation circuit to output a first pulse train and a second pulse train to a target biological tissue, determine whether an end condition of the first pulse train is satisfied based on a feedback signal transferred from the monitoring unit, and output an end command for the first pulse train to the pulse generation circuit when it is determined that the end condition of the first pulse train is satisfied, wherein the monitoring unit is communicatively connected to the control unit and is configured to obtain a feedback signal after the second pulse train is output to the target biological tissue and output the feedback signal to the control unit, the feedback signal being for the second pulse train and including a real-time voltage and a real-time current of a feedback circuit corresponding to the target biological tissue, wherein a voltage of the first pulse train is higher than a voltage of the second pulse train, and the first pulse train is used to ablate the target biological tissue, determining whether an end condition of the first pulse train is satisfied based on the feedback signal transferred from the monitoring unit, and when it is determined that the end condition of the first pulse train is satisfied, outputting an end command for the first pulse train to the pulse generation circuit, which is based on the real-time voltage and the real-time current of the feedback circuit included in the feedback signal to determine a real-time resistance value of the target biological tissue, associating the determined real-time resistance value with biological index information of the target biological tissue and displaying it, determining whether the biological index information of the target biological tissue associated with the real-time resistance value is greater than a design threshold value, and when the biological index information is greater than the design threshold value, outputting an end command for the first pulse train to the pulse generation circuit, wherein the biological index information includes at least one of a heart rate, blood pressure, and blood oxygen concentration, a pulse monitoring device.

2. The pulse generation circuit includes a first pulse generation circuit for outputting a first pulse train and a second pulse generation circuit for outputting a second pulse train. The pulse monitoring device according to claim 1, wherein the first pulse generation circuit and the second pulse generation circuit are integrated on the same circuit board.

3. The first pulse generation circuit includes at least one stage of first pulse generation units connected electrically in sequence. The first pulse generation unit is electrically connected to the control unit, is turned on under the control of the control unit, and is used to output the first pulse train to the target biological tissue, for the pulse monitoring device according to claim 2.

4. Each stage of the at least one stage of first pulse generation units includes a first capacitor, a first switch component, and a first diode. A first end of the first capacitor is electrically connected to a first end of the first switch component. The positive and negative electrodes of the first diode are electrically connected to a second end of the first capacitor and a second end of the first switch component respectively. A control end of the first switch component is electrically connected to the control unit. The pulse monitoring device according to claim 3.

5. The first pulse generation circuit includes at least one second diode. A first end of a first capacitor of a first-stage first pulse generation circuit in the at least one stage of first pulse generation units is electrically connected to a first power supply through at least one second diode. The first pulse generation circuit further includes at least one third diode. The anode and cathode of the third diode are electrically connected to two adjacent first pulse generation units respectively, for the pulse monitoring device according to claim 4.

6. The second pulse generation circuit includes at least one stage of second pulse generation units connected electrically in sequence. The second pulse generation unit is electrically connected to the control unit, is turned on under the control of the control unit, and is used to output the second pulse train to the target biological tissue. The second pulse generation unit includes a second capacitor, a second switch component, and a fourth diode. A first end of the second capacitor is electrically connected to a first end of the second switch component. The positive and negative electrodes of the fourth diode are electrically connected to a second end of the second capacitor and a second end of the second switch component respectively. A control end of the second switch component is electrically connected to the control unit. The pulse monitoring device according to any one of claims 2 to 5.

7. The pulse monitoring device further includes a display unit, the display unit is communicatively connected to the control unit, and the display unit is used to display at least one of a real-time resistance value, a real-time resistance value curve, and biometric information. The pulse monitoring device further includes an alarm unit, the alarm unit is communicatively connected to the control unit, and the alarm unit is used to issue an alarm instruction when the biometric information of the target biological tissue is greater than a designed threshold value. The pulse monitoring device according to any one of claims 1 to 5.

8. A computer-readable storage medium storing a computer program, wherein when the computer program is executed by a pulse monitoring device, Output a first pulse train and a second pulse train to a target biological tissue; Obtaining a feedback signal after the second pulse train is output to the target biological tissue, the feedback signal being for the second pulse train and including the real-time voltage and real-time current of a feedback circuit corresponding to the target biological tissue; Determining whether an end condition of the first pulse train is satisfied based on the feedback signal; When it is determined that the end condition of the first pulse train is satisfied, stopping the output of the first pulse train, to realize a pulse monitoring method including: The voltage of the second pulse train is lower than the voltage of the first pulse train, and the first pulse train is used to ablate the target biological tissue. Determining whether the end condition of the first pulse train is satisfied based on the feedback signal, and when it is determined that the end condition of the first pulse train is satisfied, stopping the output of the first pulse train is Based on the real-time voltage and real-time current of the feedback circuit included in the feedback signal, determining the real-time resistance value of the target biological tissue, displaying the determined real-time resistance value corresponding to the biological index information of the target biological tissue, determining whether the biological index information of the target biological tissue associated with the real-time resistance value is greater than a design threshold, and when the biological index information is greater than the design threshold, stopping the output of the first pulse train, The biological index information includes at least one of a heart rate, blood pressure, and blood oxygen concentration. A computer-readable storage medium.

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