How to improve your lifestyle to improve your health

Abstract

When a patient begins to feel unwell, the mental, physical and financial pressure on the patient's family becomes immense, leading to a loss of hope in life. [Solution] In the present invention, if a subject who is determined to be in poor health is immediately introduced with a lifestyle improvement product, it should not lead to further poor health. Therefore, the subject is tested by a monitor, and if the results indicate that the product is a lifestyle improvement product that will lead to improved health, the subject who is determined to be in poor health is then tested by the monitor, and if the results indicate that the product is a lifestyle improvement product that will lead to improved health, the subject can be provided with information on the product as a safe and reliable option for introducing lifestyle improvement.

Description

[Technical Field]

[0001] The present invention relates to a method for improving lifestyle habits that leads to good physical condition. [Background technology]

[0002] The incidence of Down syndrome (DS) has been increasing in recent years. Trisomy 21 (Down syndrome) is a chromosomal abnormality characterized by an extra copy of chromosome 21, which is associated with intellectual disability and delayed physical development. Regarding the mechanism of increased oxidative stress in the Down syndrome (DS) brain, superoxide dismutase 1 (SODI), App, and the transcription factor Bach1 have been identified as possible genes on chromosome 21 involved in this process. SODI is an enzyme known as an antioxidant, metabolizing superoxide to hydrogen peroxide. Hydrogen peroxide is converted to water by catalase and glutathione peroxidase, but the activity of these enzymes is lower in the brain compared to other tissues, leading to the accumulation of hydrogen peroxide. Because hydrogen peroxide produces hydroxyl radicals, the most oxidatively potent form of hydroxyl radicals, it is speculated that copying the SODI gene results in increased oxidative stress rather than an antioxidant effect. More than 60 years have passed since a French geneticist discovered in 1959 that DS is a trisomy of chromosome 21. However, much of its pathological mechanism remains unknown, and no established treatment has been established for its various symptoms. The underlying cause of chronic disease is believed to be a decline in organ function. Possible causes include overeating and drinking (cold drinks), poorly digestible food, excessive alcohol intake, lack of sleep, overwork due to physical strain, drug side effects, bacterial or viral infections, and interpersonal stress. However, the lack of established treatments to alleviate the symptoms of chronic disease means that the number of patients is increasing year by year.

[0003] Patent Document 1 also discloses that a method for diagnosing Down's syndrome includes measuring the degree of methylation level of a Down's syndrome-related gene biomarker in a biological sample. The measurement of the methylation level is performed by measuring the methylation level of a CpG site, and it is disclosed that any known method for measuring methylation levels in the art can be used without limitation.

[0004] Patent Document 2 discloses a method for reducing clinical functional decline in a subject with early Alzheimer's disease, which comprises administering a composition containing a therapeutically effective amount of at least one anti-Aβ protofibril antibody. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Patent Publication No. 2024-156700 [Patent Document 2] Special Table 2021-503770 Summary of the Invention [Problem to be solved by the invention]

[0006] In this study, the submandibular gland secretes the most salivary components into the oral cavity, accounting for 70% of secretion during rest and 62% of secretion during stimulation (when acidic stimulation occurs due to a sour taste). The salivary components secreted by the submandibular gland include IgA (immunoglobulin A), BDNF (brain-derived neurotrophic factor), albumin, cortisol, lysozyme, lactoferrin, and gastin. The saliva ORP values of these salivary components, which are secreted most frequently by the submandibular gland, are measured using a human saliva ORP measuring device (oxidation-reduction potential value) certified as a medical device. To prevent increased oxidative stress and lead to an oxidative saliva ORP value, the submandibular gland saliva ORP value is checked to determine the redox boundary range (0 mV to 30 mV) between no stress (0 mV or less) and stress (30 mV or more) in the stress level chart shown in Figure 6 (described below).

[0007] Next, the parotid gland secretes 25% of the saliva components into the oral cavity, while the submandibular and parotid glands together account for 95%. The remaining 5% comes from the sublingual gland and minor saliva. It is known that the parotid gland secretes 25% at rest and 34.8% when stimulated (when acidic, such as when a sour taste is detected). Secretion from the submandibular gland is suppressed to 62%. Salivary components secreted by the parotid gland include amylase, parotin, lactoperoxidase, histatin, and ptyalin. The salivary ORP values of the salivary components secreted predominantly by the parotid gland are measured using a human saliva ORP meter (oxidation-reduction potential value), which is certified as a medical device. To prevent increased oxidative stress and lead to oxidative salivary ORP values, the redox boundary range for determining drug stress levels, shown in Figure 7, Drug Stress Level (Screening) Chart (described below), is checked to ensure a ±0mV to 30mV range. Furthermore, saliva secretes 5% of the mucin component from the sublingual gland, and 0.2% from the minor salivary glands when stimulated. When the sympathetic nervous system is dominant in oxidized saliva, mucin secretion increases, making the mouth sticky and causing bad breath. In addition, saliva contains inorganic components such as calcium, phosphate, and sodium, as well as organic components such as antibacterial and immune substances, and these components work together to fulfill various roles, such as moistening the mouth, softening food, and suppressing bad breath. [Means for solving the problem]

[0008] The present invention involves collecting saliva components from the oral cavity of a subject and measuring the ORP of the human saliva using a human saliva ORP measuring device. The ORP value of saliva was measured, and the ORP value of saliva was used to determine whether the subject was in good physical condition or not. and determining whether the subject is in poor physical condition or not. The method is characterized by comprising the steps of: providing lifestyle improvement information that leads to good health and having the subject select an object of the information; measuring the ORP value, which is the oxidation-reduction potential, by collecting saliva from the subject before and after using the object, determining the change, and confirming in advance whether the saliva ORP value after using the object is lower in the negative potential direction or higher in the positive potential direction than the saliva ORP value before using the object, in order to confirm the effectiveness of the lifestyle improvement information object by a monitor subject; and providing information on the object of the lifestyle improvement information that is determined to lead to good health to the subject in poor health as an introduction option for lifestyle improvement. [Effects of the Invention]

[0009] Since it is important to avoid introducing a lifestyle improvement product to a subject who is deemed to be in poor health immediately, which could lead to further deterioration of health, we have focused on the idea that if a subject is tested by a monitor and the results indicate that the product is a lifestyle improvement product that will lead to improved health, the subject who is deemed to be in poor health can be tested by the monitor, and if the results indicate that the product is a lifestyle improvement product that will lead to improved health, then the subject can be provided with information on the product as a safe and reliable option for introducing lifestyle improvement.

[0010] According to medical information journals, approximately half of children with Down syndrome are known to have heart abnormalities present from birth, with ventricular septal defect and atrioventricular septal defect being the most common. In a collaborative study with a pediatrician, the applicant used a human saliva ORP measuring device certified as a medical device to track the clinical results of saliva ORP measurements of saliva samples from critically ill patients, diabetic patients, and patients with other illnesses. The results are shown in Tables 1 to 12 below. This is a valuable clinical study of saliva ORP by a pediatrician. Table 6 shows the changes in saliva ORP over time for Mr. D, an atopic and allergy sufferer whose family, through their dedication to the patient, came together to improve their dietary habits by eliminating chemical fertilizers and pesticides, and decided to change the indoor environment of their home and move. Furthermore, changes in saliva ORP were observed with the use of building materials such as paints and wall coverings made with fermented solutions extracted from natural plant extracts, wearing clothing woven with plant-derived fiber yarn, and improving dietary habits. One year after tracking the saliva clinical data, improvements in lifestyle habits were shown to improve poor health due to lack of sleep, as shown in Table 7. Furthermore, as shown in Tables 2 and 3, the saliva ORP values of critically ill patients who accepted and practiced advice on improving their lifestyle habits, including their dietary habits, did not rise to extremely oxidative ORP values above the redox boundary range of 40-50 mV, but maintained stable values. [Brief explanation of the drawings]

[0011] [Figure 1] Variation of ORP in severe cases. [Figure 2] Diagram of gross saliva collection method. [Figure 3] Diagram of the method for collecting submandibular saliva. [Figure 4] Diagram of how to collect parotid saliva [Figure 5] Physical condition chart. [Figure 6] Stress level chart. [Figure 7] Drug stress level (screening) chart. [Figure 8] Configuration of human saliva ORP measurement device. [Figure 9] Correlation of human salivary ORP with autonomic nervous system activity. [Figure 10] An overview of moderate eating that focuses on the yin and yang of food. [Figure 11] A flow of lifestyle improvement advice to lead to good health based on health status results. [Figure 12] Human saliva ORP frequency distribution table. [Figure 13] The process involves checking your physical condition and providing information on how to improve your lifestyle. DETAILED DESCRIPTION OF THE INVENTION

[0012] The stress level of the saliva components produced from the submandibular gland was confirmed by the ORP value of human saliva, and if the ORP value exceeded 30 mV, outside the redox boundary range of ±0 mV to 30 mV, due to food intake, clothing, and physical sensations in food, clothing, and shelter, the lifestyle habits in food, clothing, and shelter could be improved to reduce the body's stress levels, so that the local saliva components produced from the submandibular gland would exhibit values of 0 mV or less, in the negative direction of the redox boundary range, even if the person unfortunately had symptoms of Down's syndrome. This could prevent the progression of these conditions to Alzheimer's disease, Parkinson's disease, depression, and schizophrenia.

[0013] This is because the main saliva components produced by the submandibular gland include IgA (immunoglobulin A), BDNF (brain-derived neurotrophic factor), albumin, cortisol, lysozyme, lactoferrin, and gastin. These saliva components contain information on the growth, maintenance, and repair of extremely important nerve cells, which are directly linked to increased oxidative stress in the brain of Down syndrome (DS), as well as brain nutrition, and we focused on the fact that these saliva components contain a lot of information that affects the sympathetic and parasympathetic nervous systems, which are important for neurotransmission in the brain.

[0014] Regarding the mechanism of increased oxidative stress in the Down syndrome (DS) brain, superoxide dismutase 1 (SODI), App, and the transcription factor Bach1 have been identified as possible candidates for genes on chromosome 21 involved in increased oxidative stress. SODI is an enzyme that metabolizes superoxide to hydrogen peroxide and is an important antioxidant enzyme. Hydrogen peroxide is metabolized to water by catalase and glutathione peroxidase, but the activity of these enzymes is lower in the brain compared to other tissues. Therefore, increased SODI levels lead to the accumulation of hydrogen peroxide, which produces hydroxyl radicals, the most oxidizing agent. Therefore, it is speculated that copying the SODI gene leads to increased oxidative stress rather than an antioxidant effect. For this reason, it is important to maintain the main salivary components produced by the submandibular gland at a negative reducing ORP value, and having the salivary components at a highly oxidizing ORP value promotes an increase in the enzymes that metabolize SODI and superoxide into hydrogen peroxide, and promotes improvements in organic lifestyle habits such as food, clothing, and shelter to prevent increased oxidative stress from being induced and to prevent increased oxidative stress in the brains of people with Down syndrome (DS), which is thought to lead to the maintenance of good physical condition without placing sudden and excessive strain on the human body.

[0015] The characteristics of the major salivary components produced by the submandibular gland are described below. IgA (immunoglobulin A) is a component responsible for eliminating foreign substances such as pathogens and viruses from the body. BDNF (brain-derived neurotrophic factor) is a protein that promotes the growth, maintenance, and repair of nerve cells. It serves as a brain nutrient, protecting nerve cells from damage and supporting their regeneration. Albumin regulates the volume of blood in blood vessels and the amount of water in the body, maintaining blood osmotic pressure, and transporting various substances. Cortisol is a hormone secreted by the adrenal cortex that is involved in stress, metabolism, and immunity, and is a component that plays a role in gluconeogenesis, protein metabolism, lipolysis, anti-inflammatory properties, and immunosuppression. Lysozyme is an enzyme (protein) that breaks down bacterial cell walls and has various functions, including antibacterial and antiviral properties. Lactoferrin is found in bodily fluids such as breast milk, saliva, and tears, and is a component that plays a role in immunoregulation, antibacterial properties, and antiviral properties. Gustine is a component that is closely related to taste and saliva, and the ionic value of saliva and the presence of gustine are responsible for sensitizing taste. In cases of poor health and loss of appetite, we believe that by adopting a lifestyle that reduces the body's internal redox potential through food, clothing, and shelter, thereby keeping these salivary components below the redox boundary range of 40-50 mV, we can attenuate increased oxidative stress in the brains of people with Down syndrome (DS) and prevent progression to Alzheimer's disease, Parkinson's disease, depression, schizophrenia, and other conditions. Therefore, there is an urgent need for a method to visualize the level of oxidative stress in Down syndrome, which has been increasing in recent years. We believe that the key to preventing increased oxidative stress is to adopt a lifestyle that reduces the body's internal redox potential through food, clothing, shelter, and mental care.

[0016] The major components of saliva produced by the parotid gland include amylase, parotin, salivary lactoperoxidase, histatin, and ptyalin. Among these salivary components, amylase is a digestive enzyme that aids in food digestion, reducing gastrointestinal burden. Parotin promotes the function of muscles, bones, and internal organs, stimulating metabolism. Salivary lactoperoxidase fights oral bacteria and viruses and produces antibacterial hypothiocyanite through the reaction of thiocyanate ions in saliva with hydrogen peroxide. Histatin is a component that exerts antibacterial and antifungal effects and promotes wound healing. Ptyalin acts as a digestive enzyme by moistening the oral mucosa, hydrating food, and softening food for easier swallowing. Furthermore, the saliva components produced by the aforementioned submandibular gland contain proteins that promote the growth, maintenance, and repair of nerve cells, and act as nutrients for the brain, protecting nerve cells from damage and assisting in their regeneration, thereby preventing increased oxidative stress in the brains of people with Down syndrome (DS).In contrast, the saliva components produced by the parotid gland contain digestive enzymes that aid digestion, activate metabolism, and compensate for the functions of muscles, bones, and internal organs that deteriorate with age, as well as sterilizing toxic substances such as bacteria and viruses that invade the oral cavity.Based on these characteristics, it is important to adopt a diet that leads to a reduction in the body by consuming organic foods, and it is thought that this will prevent increased oxidative stress in parotid saliva.

[0017] As a result, by focusing on the fact that all of the saliva produced by the submandibular gland, parotid gland, sublingual gland, and minor salivary gland is collected and integrated in the center of the tongue in the oral cavity as shown in Figure 2, the overall physical condition of the subject can be evaluated using the physical condition chart in Figure 5. If the overall physical condition assessment shows a strong positive ORP value, it can be inferred that one of the saliva components secreted from the submandibular or parotid saliva is highly oxidized.Furthermore, by local saliva sampling of human saliva ORP values from submandibular and parotid saliva, using a method of pinpoint collection of saliva produced from the submandibular glands located under the jaws on both sides of the oral cavity as shown in Figure 3, human saliva ORP value stress level measurement, and the stress level chart in Figure 6, are expected to not only prevent increased oxidative stress in the brains of subjects with Down syndrome (DS), but also to prevent increased oxidative stress that leads to damage to internal organ function leading to chronic diseases.We have focused on the possibility of confirming health indicators for staying healthy by improving food, clothing, shelter, and mental care, and confirming saliva ORP values for neurotransmission after physical experience. Furthermore, by collecting local saliva using a pinpoint method of collecting saliva produced from the major salivary glands located in the oral cavity from in front of (anterior to posterior to the ears) to below (infraaural) both sides of the ear, as shown in Figure 4, and using the drug stress level chart (screening) in Figure 7, it became possible to confirm, using the saliva ORP value, the properties of saliva components that play a role in sterilizing toxic substances such as bacteria and viruses that invade the oral cavity, as well as the effects of health indicators for staying healthy by preventing overwork of internal organs before and after experiencing it through diet, clothing, and housing.

[0018] Figure 1 shows the ORP fluctuations in human saliva as a serious symptom, and is based on a Japanese medical journal. In the July 2009 issue of the Medical Publishing Company's "Clinical Testing" Vol. 1.53, the applicant of the present invention A saliva clinician who is a joint researcher with the A paper titled "Confirmation" was published that tracked the changes in human saliva ORP in two severe cases. It has been done.

[0019] Figure 2 shows a flow chart for collecting saliva components produced by all salivary glands in the oral cavity and measuring the ORP of human saliva. Figure 1-a shows saliva collection from the center of the tongue, where all saliva components in the oral cavity, which serve as a comprehensive health indicator, are concentrated. Figure 1-b shows the saliva-soaked cotton swab used to collect saliva. The cotton portion 2, the swab shaft 4, and the swab handle 5 are shown. The cotton portion of swab 2 is placed in the center of the tongue, and the mouth is closed. Since some subjects are able to collect saliva quickly while others require more time, Figure 1-c shows how the cotton portion of swab 2 is soaked with saliva at the subject's own pace.

[0020] Figure 3 shows the method for collecting saliva components produced from the submandibular gland and the flow of ORP measurement of human saliva. A cylindrical straw and a cotton swab were inserted into the left and right submandibular gland saliva collection points. This is Figure 2-a, which shows how saliva is collected using a syringe. This is how local saliva produced by the submandibular gland is collected. The cotton swab 2 is stored in the straw 3 of the cylinder so that the tip of the cylinder 3 touches the submandibular gland. Then, push out the cotton part 2 of the cotton swab, and the cotton part 2 contains the saliva components produced by the submandibular gland. Once it is immersed, retract the handle of the cotton swab held by the holder and store it in the cylinder 3. When the cylinder 3 is removed from the oral cavity of the examiner, the saliva-impregnated cotton portion stored in the cylinder 3 is The sample can be collected pinpoint without touching the tip of the tongue in the oral cavity, and is placed under the jaw. The stress level of the subject was measured using information from the function of saliva components collected from the saliva gland. This can be determined by measuring RP.

[0021] Figure 4 shows the method for collecting saliva components produced from the parotid gland and the flow of ORP measurement of human saliva. A cylindrical straw and a cotton swab were inserted into the left and right parotid gland saliva collection points. Figure 3-a shows how saliva is collected using a syringe. The cotton swab 2 is stored in the straw 3 of the cylinder, and the tip of the cylinder 3 touches the parotid gland. Then, the cotton part 2 of the cotton swab is pushed out, and the cotton part 2 is impregnated with saliva components produced by the parotid gland. Once the cotton swab is inserted, the handle of the holder is retracted into the cylinder 3. When the cotton part 2 is removed from the oral cavity of the patient, the cotton part 2 is soaked in saliva and stored in the cylinder 3. It can pinpoint the sample without touching the tip of the tongue in the oral cavity, and parotid saliva can be collected. The drug stress level of the subject was determined based on the information obtained from the saliva components collected from the test sample. This can be understood by measuring saliva ORP.

[0022] Figure 5 shows the ORP physical condition of human saliva as a health indicator, as published in a paper by Igaku Shoin. This is a graph showing the degree of quantification. The total body temperature of a person is measured by collecting saliva collected on the tongue in the oral cavity. The redox boundary range of saliva, a health indicator, is 40-50mV. The redox boundary range value of the physical condition between 40mV and 50mV is The body is reduced and in good health. It is possible to know that the body of a person is oxidized and in a poor physical condition. If the liquid ORP value is within the redox boundary range, follow-up observation is required. The ORP value of the human saliva, which is the subject, obtained by the initial measurement and the ... predetermined time The ORP value of the human saliva after the predetermined time has passed is compared with the ORP value of the human saliva after the predetermined time has passed. If the ORP value of the liquid is decreasing, it is understood that the patient is in good health, and if it is increasing, it is understood that the patient is in poor health. I can hold it.

[0023] Figure 6 shows that the redox boundary range of saliva, which is a human stress index, is 0-30mV. This is a diagram showing the results of the local collection of saliva produced from the submandibular gland in the oral cavity. The redox boundary range for stress levels between humans is 0-30mV. The redox boundary range value of stress level is 0 mV or less. The body is reduced and in a stress-free state. This means that the human body is oxidized and in a state of stress. If the saliva ORP value is within the redox boundary range, follow-up is recommended. As an observation, the ORP value of the human saliva of the subject obtained by the first measurement, The ORP value of the human saliva sample is compared with the ORP value of the human saliva sample after a predetermined time has elapsed. If the ORP value of saliva after the time has passed decreases, there is no stress. If it increases, It can be understood that there is stress.

[0024] Figure 7 shows that the redox boundary range of saliva for drug stress indicators in humans is 0-30mV. This is a diagram showing the saliva produced by local collection from the parotid gland in the oral cavity. The redox boundary range for drug stress in humans is shown to be 0-30mV. The redox boundary range value of human drug stress level is 0 mV or less. A human body is in a reduced state without drug stress. 30mV or more The human body is in an oxidized state and is under drug stress. In addition, if the saliva ORP value is within the redox boundary range, If so, as a follow-up, the human subject obtained by the initial measurement and the ORP value of the human saliva sample after a predetermined time has elapsed. In contrast, if the saliva ORP value decreases after a certain time has passed, If there is no change, or if it is elevated, it can be determined that there is drug stress. If the value is within mV, your daily eating habits may be affecting your body without you even realizing it. Food additives, chemicals used in food manufacturing and processing, vegetables, The test substances include pesticides used in fruit cultivation and feed additives contained in livestock and farmed fish feed. Understanding how artificial stimulants based on chemicals are oxidizing your body. The more positive the ORP value, the more likely the suspected However, it can be understood.

[0025] Figure 8 is a diagram showing the configuration of a human saliva ORP measuring device used in the method of measuring the ORP value of human saliva by collecting local saliva components produced from the three major salivary glands and the method of improving lifestyle habits for good health according to the present invention. A coating is formed on the surface of the indicator electrode (platinum electrode) using a graphene oxide solution that has magnetic properties, which has not been mixed into human saliva solutions in the past. The coating is removed by washing and wiping with purified water. This was not possible. After much research into this difficult problem, the applicant focused on the flexible metallic properties of pure gold and discovered that the surface could be delicately peeled off by wiping and cleaning, resulting in the use of a pure gold electrode as the indicator electrode. The applicant of the present invention has filed patent application No. 7336166. This enabled accurate capture of information from the saliva, the subject's sample fluid, in this invention. By improving and evolving the indicator electrode (pure gold electrode), the human saliva ORP measuring device 36 has been able to realize a method for visualizing the effects of providing information on lifestyle improvements in the areas of food, clothing, shelter, and mental health in the form of ORP values, a health index. The human saliva ORP measuring device 36 is equipped with three measurement boxes 42, each with the same configuration between the two electrodes, the reference electrode 32 and the indicator electrode 26. The enlarged view of the bubble shows the configuration between the reference electrode (silver-silver chloride) 32 and the indicator electrode (pure gold electrode) 26. The two opposing electrodes, the reference electrode 32 and the indicator electrode 26, calculate the electrolyte concentration of all saliva components and the activity ratio of oxidized and reduced substances, and measure the potential difference between oxidation and reduction. A minute amount of KCl solution 34 is drawn into the saliva-impregnated cotton portion 23 by capillary action through the liquid junction 30, which serves as the contact point between the saliva 23 impregnated in the cotton swab and the wetted cotton swab 23, and the KCl solution 34, which exchanges positive and negative electrons of the saliva ORP between the saliva 23 impregnated in the cotton swab and the reference electrode serving as the opposite electrode. Positive and negative electrons are exchanged via the KCl solution 34 between the two electrodes, the reference electrode 32 and the indicator electrode 26, and the oxidation-reduction potential (mV) potential difference is calculated and the measurement result is displayed on the LCD at 39. It consists of a tank lid 33 for storing the KCl solution, the shaft 22 of the saliva-impregnated cotton swab, the cotton part 23 of the saliva-impregnated cotton swab, the sample tank base 24 into which the saliva-impregnated cotton swab is inserted, and the part 25 where the saliva-impregnated cotton swab 23 and the head part of the indicator electrode 26 come into contact, and the indicator electrode 26 is fixed and glued to the bottom 29 of the sample tank.The components are a point 27 where the indicator electrode 26 and lead wire 28 are glued and connected, a point 31 where the reference electrode 32 and lead wire 28 are glued and connected, an oxidation-reduction potential mV measuring unit 35 that calculates the potential difference by exchanging positive and negative electrons between the reference electrode 32 and indicator electrode 26 with a KCl solution in between, a start button 38 to start measurement, a measurement result print button 37, an LCD unit 39 that displays the measurement results using the oxidation-reduction potential mV measuring unit 35 that calculates the potential difference, an LCD unit 40 that displays the year and time, a thermal printout 41 of the measurement results, and three measurement boxes 42 that are provided with the configuration between the reference electrode and indicator electrode.

[0026] Figure 9 shows the correlation between the ORP of human saliva and the autonomic nervous system. As shown in Figure 9, when the parasympathetic nervous system of the autonomic nervous system is relaxed, a large amount of saliva, primarily watery and serous (thin), is secreted from the parotid gland. On the other hand, when a person experiences discomfort from touch or taste and becomes tense, the sympathetic nervous system becomes stressed, causing saliva secretion from the parotid gland to be stopped and mucous (sticky) saliva to be secreted from the submandibular and sublingual glands. The ORP value of human saliva containing a large amount of watery and serous (thin) saliva exhibits a strong negative ORP value (mV), indicating good health and a reduction in the body's internal temperature. On the other hand, the ORP value of human saliva containing a large amount of mucous (sticky) saliva exhibits a strong positive ORP value (mV), indicating poor health and a reduction in the body's internal temperature. Furthermore, rather than simply increasing the amount of saliva secreted, by checking the physical condition of the salivary gland components of the present invention and improving your lifestyle to maintain good physical condition, it acts on the parasympathetic nervous system and encourages the secretion of salivary components with strong reducing effects from the total saliva, submandibular saliva, and parotid saliva that are concentrated in the center of the tongue in the oral cavity, leading to good physical condition.

[0027] Referring to Figure 10, modern society is overflowing with oxidative stressors that cause stress not only to humans but also to animals and plants. This invention consistently focuses on the idea that health can be maintained through a balanced diet by consuming foods that maintain a moderate redox state, without leaning too far to one side. This focus extends beyond food, clothing, and shelter, and also focuses on the yin and yang of food in order to restore health in this invention. For example, it is well known that eating foods that are biased toward either yin or yang can lead to poor health. Yin and yang foods refer to foods that cool the body as yin foods 70, foods that warm the body as yang foods 72, and foods that are neutral in both yin and yang as moderate foods 71. Yin foods 73 are rich in potassium and have a cooling effect on the body, while yang foods 75 are rich in sodium and have a warming effect. Foods 74 that are in between yin and yang have the effects of relaxing cells, blood vessels, and organs, cooling yin bodies, and warming yang bodies. Nature provides seasonal harvests that can be taken into the body according to the season, and a locally produced diet has long been said to be the source of good health. As shown in the Yin-Yang food chart, yin foods include soy milk, tomatoes, potatoes, eggplant, coffee, ice, and beer, while yang foods include carrots, burdock, butterbur, Chinese radish, pickled radish, Korean carrots, pickled plums, miso paste, natural salt, plum-soy-based bancha tea, and soy-based bancha tea. Foods that represent a balance between yin and yang include pumpkin, onion, lotus root, brown rice, komatsuna (Japanese mustard spinach), cabbage, Chinese cabbage, daikon radish, green onions, green laver, and kelp. A diet that balances yin and yang, centered on foods that are moderate between yin and yang, is important. We believe that this idea of yin-yang balance in food can be utilized in the lifestyle improvement advice of this invention.

[0028] Figure 11 shows the flow of health maintenance for food, clothing, shelter, and mental health, based on ORP measurements of salivary components produced by the three major salivary glands. The ORP values are used to assess physical condition for each component. The salivary components collected on the tongue are used to measure overall physical condition (9), stress level (10) is measured using local saliva collected from the submandibular gland. Finally, drug stress level (11) is measured using local saliva collected from the parotid gland. The salivary components collected on the tongue are used to assess overall whether the activity of all salivary components produced in the oral cavity is significantly oxidative or reactive (12). The main salivary components produced by the submandibular gland (13) are used to assess stress level by determining whether their activity is significantly oxidative or reactive based on ORP values. Next, the main salivary components produced by the parotid gland (14) are used to assess drug stress level by determining whether their activity is significantly oxidative or reactive based on ORP values. After understanding these health effects, in cases of significant oxidative stress-related poor health, the effectiveness of taking care of food, clothing, shelter, and mental health, including diet, is shown in Tables 1 to 10 below, based on a consideration of factors that cause increased oxidative stress15.

[0029] Figure 12 is a human saliva ORP frequency distribution table. A total of 13,000 cases were measured between 1996 and 2018 by a collaborative researcher (pediatrician, internist, and director of Okazawa Clinic) and the present applicant, who conducted these measurements with consent from patients and their families. These saliva ORP measurements were based on the accumulated data from clinical saliva analysis, revealing the following: physical condition index (oxidation-reduction boundary range: 40-50mV); stress index (oxidation-reduction boundary range: 0-30mV); and drug stress index (screening: 0-30mV). Based on patient records, the collaborative researcher's ORP saliva clinical physician statistically determined the difference between sick and healthy patients, from infants to the elderly, who visited the clinic for health consultations. The frequency distribution table allowed for this determination.

[0030] Figure 13 shows the process for providing information on lifestyle improvement options to subjects who are diagnosed as being in poor health. (17) To determine whether a subject is in poor health, a human saliva ORP analyzer is used to collect three types of saliva samples: one from the submandibular gland in the subject's mouth, one from the parotid gland, and one collected on the tongue. This information is then used to determine whether the subject is in good or bad health. (19) Next, the content of lifestyle improvement information provided to the subject and the health impact of the information provided on the subjects' lifestyle options are confirmed. After accepting, selecting, and implementing the lifestyle improvement information, the subject uses the human saliva ORP analyzer to confirm the improvement effect, which is leading the subject from poor health to good health, allowing them to experience the hope and joy of regaining their energy. (20) [Example]

[0031] In the examples, the present inventors conducted a collaborative study with a saliva clinician to verify the effectiveness of lifestyle improvements for improving physical condition, starting with physical condition assessment. Based on Figures 1 to 13, after assessing physical condition, the saliva clinician who measured human saliva ORP provided detailed and thorough advice on lifestyle improvements, diet, clothing, housing, and mental health. Patients who accepted this advice demonstrated reduced oxidative stress and improved physical condition, as demonstrated in Tables 1 to 12. Tables 13 to 20 were also presented to demonstrate the effectiveness of accepting this lifestyle improvement information. As shown in the flowcharts of Figures 11 and 13, we focused on providing information to subjects who were diagnosed with poor physical condition as an option for introducing lifestyle improvements. As shown in Figure 1 and Table 1, the longitudinal records of a patient who was diagnosed with multiple sclerosis and later a brain tumor are still being recorded as of April 2025, with ORP measurements of total saliva, submandibular saliva, and parotid saliva continuing with written consent from the patient and his or her family. The human saliva ORP measuring device used for continuous measurements can be used by anyone, not just medical professionals, and is approved by the Japanese Ministry of Health, Labor and Welfare as a general medical device and a medical device requiring specific maintenance, as specified in the accompanying documentation for the medical device.

[0032] Table 1 shows a 23-year longitudinal record of human saliva ORP data for Patient T, who was diagnosed with a brain tumor. Patient T, whose data appear in Table 1, is the patient diagnosed with a brain tumor and described in the ORP fluctuations in the severe case in Figure 1. The longitudinal record shown in Table 1 demonstrates that the salivary ORP clinician provided lifestyle improvement advice to the patient and his family. The patient's family accepted the advice and implemented lifestyle improvements, including those related to food, clothing, and shelter, as well as mental health. These improvements were clearly reflected in the overall salivary health index, the submandibular salivary stress index, and the parotid salivary drug stress index (screening). In May 2003, when the patient suddenly began to lose sight of the words written on the blackboard during a high school class, the redox boundary range for health index was 40–50 mV, as shown in Figure 5, exceeding the redox boundary range of 69 mV. The redox boundary range for stress index was 0–30 mV, as shown in Figure 6, exceeding the stress redox boundary range of 56 mV. The redox boundary range of the drug stress level is 0-30 mV, as shown in Figure 7, and at this time it was -14 mV. At the time of diagnosis in June 2004, when the patient was first diagnosed with multiple sclerosis, the physical condition index was 89 mV. The stress index was 73 mV. The drug stress index was -3 mV. At the time of diagnosis of brain tumor in April 2005, the physical condition index was 115 mV. The stress index was 71 mV. The drug stress index was +16 mV. At the time of emergency hospitalization in June of the same year, the physical condition index was 165 mV. The stress index was 82 mV. The drug stress index was +21 mV. At the time before chemotherapy in July of the same year, the physical condition index was 77 mV. The stress index was 52 mV. The drug stress index was +21 mV. At the time chemotherapy began in August of the same year, the physical condition index was 132 mV. The stress index was 61 mV. The drug stress level was plus 79mV. At the time chemotherapy was stopped in February 2006, the physical condition level was 80mV. The stress level was 62mV. The drug stress level was plus 54mV. At the time advice on lifestyle improvement was given in March of the same year, the physical condition level was 51mV. The stress level was 48mV. The drug stress level was plus 33mV, showing a downward trend.As of July 2007, four years after the onset of the disease, the ORP value showed clear changes, with the physical condition index at 42 mV. The stress index at 23 mV. The drug stress index at -3 mV. As of June 2009, the patient felt a sense of relief at having managed to postpone high school graduation by two years. He also made lifestyle changes, including "drinking warm plum and ginger bancha tea every morning," "sprinkling black sesame seeds on brown rice and chewing it thoroughly," and even incorporating organic wall materials and soothing music. The ORP values for the three physical condition, stress, and drug stress indexes all showed ORP values below the redox boundary range, indicating good physical condition. As of December 2024, 23 years after the onset of the disease, the patient's physical condition, stress, and drug stress index still showed good ORP values, indicating he was living a healthy daily life. Japanese people have long incorporated plum and ginger bancha tea, brown rice, and black sesame seeds into their daily diets, believed to be beneficial for their health. The ingredients used in umesho bancha, such as sannen bancha tea, pickled plums, black sesame seeds, brown rice, pumpkin, apples, and radishes, are in the balance of yin and yang in the diet. To make umesho bancha, pour hot sannen bancha tea from a teapot into a mug, add half a teaspoon of soy sauce, one medium-sized pickled plum, and a thumb-sized piece of grated ginger. Stirring with a spoon, drinking the tea warms the body, prevents hypothermia, and is expected to be effective in improving poor health. This is evidenced by the ORP value of Patient T's physical condition, which is stable in the negative direction, compared to the ORP value of the redox boundary range shown in Table 1. umesho bancha tea is one of the lifestyle improvement recommendations made by the aforementioned saliva ORP clinician to patients and their families, and its combined effects with dietary improvements have been demonstrated.

[0033] [Table 1]

[0034] Table 2, an implementation verification, shows the longitudinal record of human saliva ORP over a three-year period for Patient A, who was diagnosed with diabetes. At the time of his visit in July 2011, his saliva ORP was 94 mV. After following the advice of a saliva clinical physician to "drink pesticide-free bancha tea," "avoid sweets," "chew food thoroughly at least 30 times," "drink hot spring water pumped from deep underground," and "watch soothing music and nature videos, even if it's just for a short time," Patient A's saliva ORP was 70 mV at the time of his visit in August 2011. While his saliva ORP was slightly higher than the redox threshold for his physical condition, subsequent follow-up showed no significant fluctuations, demonstrating the effectiveness of lifestyle improvements in food, clothing, and shelter.

[0035] [Table 2]

[0036] Table 3 shows the experimental results for the human saliva ORP of Patient B (an infant) diagnosed with chromosome 16-9 abnormality, pulmonary artery stenosis, and ventricular septal defect. The ORP (mV) was recorded over a 26-month period from 2006 to 2008. At the time of his visit in February 2007, the ORP was 105 mV. The saliva clinician recommended the patient to "enjoy soothing music by WA Mozart and nature videos," "eat and drink at body temperature," and "watch and eat for short periods of time to avoid overheating and to inhale the clean oxygen from plants bathed in early morning sunlight." The family members accompanying the patient also followed the advice, saying, "If the patient has difficulty falling asleep, gently and gently massage the soles of the patient's feet with warm hands." However, at the time of his visit in February 2008, the ORP value of Patient B was 58 mV. This clearly demonstrated that there were no significant fluctuations in the saliva ORP value. Whether the sky is cloudy or blue, breathing in fresh oxygen produced by plants that have undergone photosynthesis under light is a cost-free and open-ended healing activity. Furthermore, a patient's family member who dedicatedly massaged the soles of their feet told the aforementioned clinical doctor with joy that when they couldn't fall asleep, massaging their feet warmed them up, and they began to snore and fall asleep before they even realized it.

[0037] [Table 3]

[0038] Table 4 shows the ORP (mV) of human saliva from three patients with Down's syndrome, Q, R, and S. The ORP (mV) was recorded over time from 2008 to 2010. The saliva ORP clinical doctor is a pediatrician and internist, and the three patients who visited the hospital for health consultations on Down's symptoms showed saliva ORP values that were slightly higher than the redox boundary range of 40-50mV, which is the physical condition index, on rainy or cold weather.However, when the ORP values were high during their first visit, the accompanying family members and the patients were kindly advised by the saliva clinical doctor to "keep your hands, feet, neck, and body warm, and inhale fresh sunlight and air (oxygen) in the early morning," "avoid cold foods and drinks, eat and drink at body temperature," and "have the patients watch and eat soothing music or videos of nature, even if only for a short time." Thanks to the dedicated actions of the accompanying family members, the physical condition of the three patients, Q, R, and S, has stabilized at around the redox boundary range of 40-50mV. The ORP value when the patient visited the hospital looking healthy and with a bright smile indicated a good health ORP value below the redox boundary range of 40-50mV, and compared with the ORP value at the first visit, the effectiveness of accepting and implementing the information provided as an introduction option for lifestyle improvement was demonstrated. Note that there are months when there is no record of the patient's ORP value because the patient did not visit the hospital due to various circumstances on their family's behalf.

[0039] [Table 4]

[0040] Table 5 shows the experimental results for the human saliva ORP of an IVF infant, Patient C, diagnosed with strabismus and macrosomia. The ORP (mV) was measured over a 27-month period from 2007 to 2008. The ORP (mV) was 103 mV at the time of the September 2007 visit. When this high ORP value was detected, the saliva clinician advised the patient to "keep their hands, feet, neck, and body warm, and breathe in fresh early morning sunlight and oxygen," "avoid cold foods and drinks, and consume foods and drinks at body temperature," "encourage them to eat and drink only for short periods, such as with the Asai germanium health supplement," and "encourage them to watch and eat soothing music and nature videos." Thanks to the dedicated actions of the accompanying family, Patient C's saliva ORP value stabilized and showed no significant fluctuations at the time of the February 2008 visit.

[0041] [Table 5]

[0042] Table 6 shows the ORP (mV) of human saliva from Patient D, diagnosed with atopic dermatitis, allergies, and hay fever. This is a seven-year record of ORP (mV) from 2006 to 2012. At the time of his July 2006 visit, his saliva ORP was 73 mV. A saliva clinician recommended that, if possible, Patient D move to a rural area with cleaner air. Following this advice, Patient D's ORP was 79 mV in February 2007. He grew up with his family from early elementary school through junior high school graduation, and returned to the city for high school. Measurements resumed in January 2012, when the ORP was measured at 32 mV. The ORP value was negative, falling below the redox threshold of 40-50 mV for health assessment. This clearly demonstrates that spending time in a pollen-filled cedar forest and breathing in the fresh air (oxygen) provided by photosynthesized plants led to Patient D's stable internal health.

[0043] [Table 6]

[0044] Table 7 shows the ORP of human saliva from Patient E, who complained of insomnia caused by the mental stress of being an emergency responder. This is a three-year record of ORP (mV) from 2008 to 2010. At the time of his visit in June 2008, his ORP was 97 mV. He followed the advice of a saliva clinician, including "drinking warm plum and ginger bancha tea," "chewing food thoroughly at least 30 times," "the Asai germanium health food," "brushing his teeth with natural salt," "dissolving one teaspoon of natural salt in a teacup with hot water when he wakes up in the morning," "not smoking," "keeping his body warm while sleeping," and "watching soothing music or nature videos, even if it's just for a short time, before going to bed," but his ORP was 70 mV at the time of his visit in January 2010. After that, although the saliva ORP value was slightly higher than the redox boundary range of 40-50mV for physical condition, the ORP value no longer showed strong oxidation in subsequent follow-up observations, and the saliva clinical physician stated that Patient E's physical sensations of extreme stress due to lack of sleep had decreased, and the value remained stable at a value close to the redox boundary range of 40-50mV for physical condition.

[0045] [Table 7]

[0046] Table 8 shows the ORP value of human saliva from Patient F, who complained of lethargy due to hypothyroidism. This is a three-year record of ORP (mV) from 2011 to 2013. At the time of his November 2011 visit, his ORP was 106 mV. After following the advice of a saliva clinical physician to "drink warm, pesticide-free bancha tea," "take time to chew thoroughly at least 30 times," "incorporate fermented foods such as miso and pickles," and "avoid excessive processed foods and sweets," Patient F's ORP value was 75 mV at the time of his September 2012 visit. Although his saliva ORP value was slightly higher than the redox boundary range of 40-50 mV for physical condition, it was clearly indicating a trend toward a reduced value, and his ORP value has remained stable.

[0047] [Table 8]

[0048] Table 9 shows the ORP (mV) of human saliva from Patient G, who was diagnosed with Sjögren's syndrome. This is a two-year record of ORP (mV) from 2009 to 2011. At the time of his visit in March 2009, the ORP was 93 mV. After following the advice of a saliva clinician, including "drink warm, pesticide-free bancha tea," "take your time and chew thoroughly at least 30 times," "eat fermented foods like miso and pickles," "avoid overeating instant foods and sweets," "avoid chilling your hands, feet, and neck," and "be careful not to overheat your body and breathe fresh air (oxygen) produced by plants through photosynthesis in the early morning sunlight," Patient G's ORP was 70 mV at his return visit in June 2010. While this ORP is slightly higher than the redox boundary range of 40-50 mV for physical condition assessment, it clearly demonstrates that following the advice led to a reduction in the ORP.

[0049] [Table 9]

[0050] Table 10 shows the ORP of human saliva of Patient H, who complained of abdominal pain. This is a three-year record of ORP (mV) from 2008 to 2010. At his November 2008 visit, the ORP was 99 mV. After receiving advice from a saliva clinician, including "drink warm, pesticide-free bancha tea," "don't eat quickly, chew your food at least 50 times," "avoid cold beer and alcohol," "don't smoke," "avoid processed foods and sweets," and "keep your hands, feet, and neck warm and sleep warm," Patient H followed the advice. At his April 2009 visit, the ORP was 62 mV. At his July 2010 visit, the ORP was 63 mV. Furthermore, by August of the same year, the ORP was 49 mV. While the strong oxidation values of around 100 mV were observed in October and November when he visited with abdominal pain, the ORP was within the redox boundary range of 40–50 mV, clearly demonstrating the effectiveness of following the advice.

[0051] [Table 10]

[0052] Table 11 shows the ORP of human saliva from Patient J, who was diagnosed with lung cancer. This is a three-year record of ORP (mV) from 2012 to 2014. When he visited the hospital in February 2012, it was 112mV. When he visited the hospital in June 2012, it was 145mV. After being diagnosed with lung cancer at a general hospital and starting chemotherapy and MRI scans in August 2012, when he visited the hospital in September 2012, it was 166mV. When he visited the hospital in October 2012, it was 153mV. At this point, Patient J followed the advice of the saliva clinician: "Drink warm, pesticide-free bancha tea," "Take time to chew your food thoroughly, at least 30 times," "Avoid cold foods and drinks," "Completely quit smoking and alcohol," "Gargle with natural salt and brush your teeth," "Avoid chilling your neck and stomach," and "Listen to soothing music and take short walks in forest parks." At the time of his visit in December 2012, his saliva ORP value was 85 mV. While this was somewhat high, it was 68 mV as of January 2013. Since then, the ORP value has not fluctuated significantly, and it has never returned to the very high value it was at the time of his visit. Patient J felt that his bloody sputum, chest pain, cough, and shortness of breath had disappeared, and his physical condition was clearly stabilized at a value close to the redox boundary range of 40-50 mV. The effects of improving lifestyle habits such as eating an organic diet and abstaining from tobacco and alcohol were clearly demonstrated, and the implementation verification shown in Tables 1 to 12 demonstrated the effectiveness of the lifestyle improvement method of the present invention that leads to good physical condition.

[0053] [Table 11]

[0054] The experimental verification in Table 12 involved the total saliva produced in the oral cavity and concentrated in the center of the tongue, saliva produced from the left and right submandibular glands, saliva produced from the left and right parotid glands, and sublingual saliva produced directly under the tongue in three seriously ill patients: Patient A undergoing breast cancer treatment, Patient B for electromagnetic hypersensitivity, and Patient C for brain tumor treatment. For Patient A undergoing breast cancer treatment, comparing the ORP values produced from each salivary gland before breast cancer treatment with the ORP values before and after anticancer drug treatment and after ingesting germanium as a health food showed efficacy leading to reduced ORP values. For Patient B for electromagnetic hypersensitivity, comparing the ORP values before treatment with those after ingesting germanium on pesticide-free vegetables showed efficacy leading to reduced ORP values. Patient C, who was undergoing treatment for a brain tumor, switched from drinking hot spring water pumped up from deep underground to eating organic vegetables and consuming germanium before treatment, and this was shown to be effective in reducing ORP values compared to before treatment.The three patients who accepted the information provided as an introduction to lifestyle changes clearly improved their poor health in saliva ORP values, proving that this was a combined effect of the introduction of lifestyle changes.

[0055] [Table 12]

[0056] Table 13 shows the human saliva ORP recorded during deep breathing by five subjects. As shown in Tables 1 to 12 of the aforementioned experimental study, a saliva clinician, a collaborator with the present applicant, advised patients with poor health ORP values to inhale clean oxygen from plants exposed to early morning sunlight. To demonstrate that the longitudinal records of patients who accepted and practiced this advice clearly demonstrated ORP values in the direction of reduction, leading to improved health, the five subjects took in air (oxygen) under normal conditions while sitting by a window in a second-floor apartment building with lush trees visible when the windows were open, and observed changes over time from 1 minute to 60 minutes after taking deep, slow breaths. The experimental study included three deep breathing patterns in the same location: one with the window open and breathing in early morning air; one with the window open and breathing in daytime air, as described above; and one with the window open and breathing in evening air, as described above. This test was conducted in May 2024 during the warm season to ensure that saliva ORP values were not affected by body cooling caused by opening and closing windows. The results shown in Table 13 clearly show differences in reduction values when comparing saliva ORP values when breathing early morning air, during the day, and in the evening, demonstrating the effectiveness of breathing fresh air (oxygen) provided by plants through early morning photosynthesis. This suggests that early morning air is freshest throughout the day, and that oxygen gradually decreases over time due to the operation of artificial industrial facilities and other ecosystem phenomena. As the sun sets and darkness sets, oxygen levels decrease as sunlight-driven plant photosynthesis ceases. People with respiratory and brain disorders are prone to seizures due to oxygen deficiency around 3:00–4:00 a.m. before dawn. Emergency transport requests and ambulance dispatches peak between 4:00 and 5:00 a.m., corresponding to the predawn time when oxygen levels are low. Based on this, the applicant of the present invention has concluded that if one does not rest and refrain from overeating, drinking and drinking alcohol, and extreme exercise, which deplete the body's oxygen when the oxygen levels are low after sunset, this will increase oxidative stress in the body and lead to poor health.Based on this, we have noticed that when providing information to subjects who are deemed to be in poor health about options for improving their lifestyle habits, we can provide them with information that suggests taking deep breaths of oxygen (air) provided by photosynthesis in early morning sunlight, which is deemed to lead to good health.

[0057] [Table 13]

[0058] The experimental verification in Table 14 records the ORP values of human saliva from eight subjects. As shown in Tables 1 to 12 of the experimental verification, a saliva clinician, a collaborator with the present applicant, advised patients who showed poor ORP values indicating poor health to "inhale clean oxygen" and "regard their living environment." The longitudinal records of patients who accepted and practiced the advice clearly showed ORP values in a direction toward reduction, leading to good health. In recent years, there has been an increase in cases of people with atopic dermatitis or allergies becoming ill due to sick building syndrome caused by building materials. Therefore, before entering a completed home, a paint containing a blend of extracts from natural plants, including Japanese knotweed, mugwort, and persimmon leaves, fermented and aged, was used. Without entering the completed room, some of the building materials used in the construction work utilized the biological function of transcutaneous respiration of human skin. A practical verification of human saliva ORP values was conducted by having the palms of the human body touch wallpaper coated with the paint. The results showed that the ORP values measured before and after touching the saliva, which indicate physical condition (ORP) measured from the whole saliva collected in the center of the tongue in the oral cavity, and the ORP values measured from the local saliva collected from the submandibular gland, clearly lead to improved physical condition. The saliva clinician gave advice on living environments to patients whose ORP values indicated poor physical condition. Patients who accepted the advice showed negative ORP values, suppressing increased oxidative stress. This demonstrated the effectiveness of providing information as an introduction to lifestyle changes. This is one example of how ORP values can be used to determine whether or not physical condition is improved by exposing parts of various construction materials to human body parts.Based on this, we have realized that the target for providing information to subjects who are determined to be in poor health about the introduction of lifestyle improvement habits is a residence that is determined to lead to good health, without entering the residence.The ORP value, which is the oxidation-reduction potential, is measured by collecting saliva from the subject before and after touching the skin of the subject's body part with some of the building materials used in the interior construction of the residence, and the change is determined.By confirming in advance whether the ORP value after touching the subject's body part is lower or higher in the negative potential direction than the ORP value before touching, it is possible to confirm in advance whether the object will lead to good health by bringing the body in a reduction direction, or to lead to bad health by bringing the body in an oxidation direction, and then provide information about the residence that is determined to lead to good health to the subject who is determined to be in poor health as an introduction option for lifestyle improvement.

[0059] [Table 14]

[0060] The experimental verification in Table 15 shows the human saliva ORP records experienced by seven subjects while wearing organic cotton socks. A saliva clinician, a collaborator with the present applicant, advised Patient H, shown in Table 10, who showed ORP values indicating poor physical condition, to "keep hands, feet, and neck warm and sleep warm." This advice was given based on a longitudinal record of the patient, who accepted and followed the advice. To prove that Patient H's ORP value in Table 7 moved from a state exceeding 100 mV to a reduction-oriented ORP value approaching the redox boundary range of physical condition shown in Figure 5, the experimental verification was conducted using the human saliva ORP values experienced while wearing organic cotton socks. As a result, the ORP values measured from saliva collected in the center of the tongue in the oral cavity, compared before and after wearing the product, clearly demonstrating improved physical condition after wearing the product. This demonstrated the effectiveness of the product, demonstrating that oxidative stress did not increase in patients who accepted the advice of the saliva clinician who showed ORP values indicating poor physical condition, but rather was reduced. Based on this, it was determined that information on lifestyle improvement options for subjects who were determined to be in poor physical condition could be provided to them in the form of organic clothing made from natural materials known to lead to improved physical condition, such as cotton, hemp (plant fiber), flax (linen), silk, wool, cashmere, alpaca, angora, mohair, camel, and organic cotton.

[0061] [Table 15]

[0062] The practical verification in Table 16 involved the evaluation of saliva ORP after eating lemons and apples grown without chemical fertilizers or pesticides, with and without preservatives, mold inhibitors, or drying inhibitors. Even in fruits grown in H, the effects of chemical preservatives penetrate the flesh through the skin, clearly demonstrating the effects of these preservatives, leading to oxidative saliva ORP values in the body. Meanwhile, lemons and apples grown without preservatives showed higher saliva ORP values. Based on this, we believe that providing information on lifestyle improvement options to subjects perceived to be in poor health could be achieved by providing information on organic foods grown without chemical fertilizers or pesticides, which are perceived to lead to improved health.

[0063] [Table 16]

[0064] The experimental verification in Table 17 shows human saliva ORP records taken by 20 subjects before and after taking the health food Asai Germanium. A saliva clinician, a collaborator with the present applicant, provided information to Patients C and E, who showed ORP values indicating poor health, as shown in Tables 5 and 7, as an option for lifestyle improvement. To verify the effectiveness of the longitudinal records after taking Asai Germanium, a comparison of the ORP values taken by the 20 subjects before and after taking Asai Germanium clearly showed that the ORP values after intake were lower in the negative direction than the redox boundary range shown in Figure 5. This proves that the longitudinal records in Tables 5 and 7 are a combined effect, and that taking Asai Germanium leads to improved health. The term "health food" as used here is a general term for foods sold as being useful for maintaining and improving health, and although there is no clear legal definition, it is generally known to refer to foods that are consumed in the hope of supplementing a nutritionally balanced diet, moderate exercise, and sufficient rest, or in the hope of achieving specific health benefits. Based on this, we focused on the idea that when providing information on lifestyle improvement options to subjects who are perceived to be in poor health, health foods perceived to lead to said good health can be provided as options for said lifestyle improvement.

[0065] [Table 17]

[0066] The experimental results in Table 18 visualized the soothing effects of five three-minute product advertisements using a human saliva ORP measurement device, a health indicator. Music was incorporated into the advertisements to complement the visuals. Using five different types of visual and musical expressions, the ORP values of four monitor subjects before and after viewing clearly indicated a difference between advertisements that promote health improvement and those that promote health oxidation. Therefore, when a saliva clinician, a collaborator with the present applicant, provides information on lifestyle improvement options, the target of the selection is based on advice that respects the laws of nature. Based on this, we have come to the conclusion that if various things or experiences such as food, clothing, housing, the sounds of birdsong, forest bathing, daily necessities, videos, paintings, music, art appreciation, contact with birds or animals, contact with insects or plants, contact with seafood, and playing in the sea are understood to lead to good physical condition, information can be provided.

[0067] [Table 18]

[0068] Table 19 shows the results of a practical test using a human saliva ORP meter to visualize health indicators before and after ingesting three types of salt: natural salt (natural salt), rock salt, and refined table salt (table salt). Table salt refers to highly refined, highly purified sodium chloride (NaCl) and contains almost no minerals other than sodium chloride. In contrast, natural salt or rock salt contains minerals such as magnesium, potassium, and calcium in addition to sodium chloride. However, when comparing ORP values before and after ingesting natural salt and rock salt, both showed a very strong reduction in ORP immediately after ingestion. However, after ingesting rock salt, ORP values exceeded those before ingestion over time, and physical condition, stress level in submandibular saliva, and drug stress level in parotid saliva all showed a positive ORP increase. Based on this, we hypothesize that natural salt, harvested amid the constant ebb and flow of the tides, may be a salt that retains its fresh energy. On the other hand, rock salt is salt that has been trapped on land by tectonic activity and crystallized over many years, solidifying into rock-like salt. Therefore, we hypothesized that its energy content may have lost its freshness. As previously mentioned, it is well known that table salt contains almost no minerals other than sodium chloride. The ORP values after ingesting table salt (refined salt) showed a strong oxidizing ORP value over time compared to the ORP values before ingestion. Furthermore, it is well known in specialist literature that magnesium, abundant in natural salt (natural salt), activates neuronal activity in the cranial nerves. A saliva clinician, a collaborator with the present applicant, provided information on lifestyle improvement options, including "brushing teeth with natural salt" and "dissolving one teaspoon of natural salt in a teacup with hot water and drinking it in the morning," as shown in Table 7. Patient E, who incorporated these lifestyle improvements into his chronic records, demonstrated their effectiveness, as shown in Table 19. In addition, just like consuming natural salt, drinking water, which is an important source of hydration for the human body, can also be checked in advance.

[0069] [Table 19]

[0070] Table 20 presents the results of a practical verification using a human saliva ORP analyzer to visualize health indicators before and after consumption of three types of drinking water: underground hot spring drinking water, mineral water, and tap water. Underground hot spring drinking water originates from deeper geological layers than typical mineral water, making it less susceptible to oxidation and contamination and pure enough to be consumed straight from the source. Mineral water is sourced from groundwater or springs, and is bottled after undergoing processes such as filtration, sedimentation, and heat sterilization. Tap water is purified water drawn from the source and supplied to homes after undergoing chlorination and other treatments. It meets strict water quality standards under the Water Supply Act and is potable. Patient A (Table 2) and Patient C (Table 12) underwent practical verification to verify the effectiveness of the introduction of drinking water as a lifestyle change, even if it was a compound effect of multiple factors.

[0071] [Table 20]

[0072] The experimental results in Table 21 visualized health indicators before and after wearing jewelry using a human saliva ORP measurement device. In recent years, many people, regardless of age or gender, have been wearing jewelry made from a variety of materials, often without checking the health effects of these accessories. For patients diagnosed with poor health, we believe that caring about appearance and the desire to look beautiful are important. Therefore, we focused on the health effects of jewelry wearing. In the experimental test of an example of jewelry, as shown in Table 21, the human saliva ORP values before and after wearing the jewelry were clearly indicated. Therefore, we believe that wearing jewelry can also be used to provide information to patients as one of the lifestyle improvement methods for improving health that this invention provides.

[0073] [Table 21]

[0074] The applicant of the present invention has already applied for the following patents (e.g., Patent No. 6142122, Patent No. 6251878, Patent No. 6253171, Patent No. 6454836, Patent No. 7065236, Patent No. 7065247, Patent No. 7282990, Patent No. 7336166, Patent No. 7339468, Patent No. 7454737, and Patent No. 7364935) which confirm the effects on human health.

[0075] The reasons why we have undertaken the present invention for developing a method for measuring the ORP value of human saliva by locally collecting saliva components produced from the salivary glands and a method for improving lifestyle habits for good health will be described below. The applicant of the present invention has used a human saliva ORP measuring device to examine the internal phenomena that lead from poor health to good health. By examining the detailed disease progression and long-term records of saliva ORP in a total of 13,000 cases by a human saliva ORP clinician, the applicant believes that by improving lifestyle habits such as organic clothing, organic food and housing, health foods, mental care (appreciation of art such as music, fine art, and video), contact with animals, inhaling fresh oxygen emitted from plants, sunlight, the purifying effects of seawater, and incorporating more natural materials, even in the unfortunate event of serious illness, such improvements in lifestyle can prevent the progression of oxidative stress and bring the body's oxidized state to a reduced state, a result that the patient can physically and tangibly experience beyond their own subjective feeling or guess. Furthermore, by visualizing and confirming the redox ORP using scientifically objective numerical data, the applicant believes that Tables 1 to 20 and Figures 1 to 13 of the present invention can show that even in the event of illness, improvements in lifestyle habits such as organic clothing, organic food and housing, health foods, mental care (appreciation of art such as music, fine art, and video), contact with animals, inhaling fresh oxygen emitted from plants, sunlight, the purifying effects of seawater, and incorporating more natural materials can restore the will to live, even in the event of illness.

[0076] The present applicant also believes that the kind and considerate manner in which a co-researcher, a saliva clinician, carefully and patiently explains lifestyle modification options to patients and their accompanying family members who show ORP values indicating poor health is a true example of mental care. In a book published by the saliva clinician, "Heaven's Consideration," the doctor states, "A doctor's only choice is to seek out and select the appropriate support and treatment methods to help a patient recover, and then carefully explain the details to the patient. The final decision on treatment is up to the patient and their family. We respect their choices, help them achieve the best possible results, and are most pleased to see the smiles of patients who have overcome their illness." Furthermore, "I believe that overcoming an illness should not be solely the doctor's achievement. I believe that the people who praise and celebrate more than anyone else are the ones who have achieved this, and that this is the achievement of the patient and their family, who have dedicated themselves to treatment with pure hearts." These words struck a chord with me, and I focused on the present invention's method for measuring human saliva ORP values using saliva components collected from the salivary glands in the oral cavity and the lifestyle modification method that leads to good health. While simply introducing subjects diagnosed with poor health to lifestyle improvement information determined to lead to improved health would amount to the act of programming an AI program, the focus of this invention is on the act of providing thoughtful advice to subjects diagnosed with poor health regarding lifestyle improvement information in areas such as diet, clothing, housing, and mental health. This is not simply about conveying the lifestyle improvement information; the loving tone, facial expressions, and gestures of the person giving the advice are important. This is considered to be mental care for humans that only a human can provide, connecting with those who are anxious due to poor health and boosting their immune system to improve their health. As shown in Tables 1 to 12 of the Examples, patients who accepted this advice experienced reduced oxidative stress. [Industrial Applicability]

[0077] When a patient develops poor health, the mental, physical, and financial pressures placed on the patient's family can become so great that they lose hope in life. This invention allows patients and their families to feel that they are regaining their health themselves, and in choosing a method to regain hope and joy in living a long life, it allows patients and their families to feel that they are regaining their health, confirm this with objective saliva ORP value data, and give them a goal to regain their health and a sense of purpose in life. This will reduce the burden of medical expenses, which increases year by year, and an increase in healthy people will lead to more compassion for others and more smiles, which will greatly contribute to healthy lives for people of all ages. [Explanation of symbols]

[0078] 1-a Enlarged view of the central part of the tongue in the oral cavity. 1-b A cotton swab for collecting saliva. 1-c Place a cotton swab on the center of the tongue inside the mouth to collect saliva. 2 The cotton part of a cotton swab. 2-a Enlarged view of the submandibular gland in the oral cavity. 2-b Illustration of straws and cotton swabs for collecting local saliva. 2-c Diagram of local saliva collection from the submandibular gland. 3 straw cylinders. 3-a Enlarged view of the parotid gland in the oral cavity. 3-b Illustration of straws and cotton swabs for collecting local saliva. 3-c Diagram of local saliva collection from the parotid gland. 4 Cotton swab shaft. 5 Cotton swab handle. 6 Insert and remove the cotton swab from the straw. 9 Total saliva (physical condition). 10 Submandibular saliva (stress level). 11. Parotid saliva (drug stress level). 12 The total saliva components that are concentrated on the tongue in the oral cavity. 13 A salivary component produced by the submandibular gland. 14 A salivary component produced by the parotid gland. 15. Improving lifestyle habits: "food, clothing, shelter + mental care." 17 Know whether you are feeling unwell. 18. Information provided on lifestyle improvement and how to confirm its impact on health. 19 The subjects selected information on lifestyle improvement, put it into practice, and then confirmed that they were in good health. 22 Saliva-impregnated cotton swab shaft. 23 The cotton part of a saliva-impregnated cotton swab. 24 The base of the sample tank where the cotton swab is inserted. 25 The head of the indicator electrode (pure gold electrode) that comes into contact with the saliva-soaked cotton swab. 26 Indicator electrode (pure gold electrode). 27 The point where the indicator electrode and lead wire are connected. 28 leads. 29 Bottom of sample tank. 30 Liquid junction. 31 The part to be glued and connected. 32 Reference electrode (silver-silver chloride). 33 Tank lid for storing KCl solution. 34 KCl solution. 35 Redox potential mV calculation measurement unit. 36 Human saliva ORP measuring device. 37 Measurement result print button. 38 Start button to begin measurement. 39 LCD display that displays the measurement results. 40 LCD display for the year and time. 41 Thermal printout of measurement results. 42 Measurement box. 70 negative foods. 71 Moderate food. 72 Positive Foods. 73 Negative foods. 74. Moderate Food. 75 positive food.

Claims

1. Saliva components were collected from the subjects' mouths. The saliva ORP value was measured using a human saliva ORP measuring device. a step of determining whether the subject's physical condition is good or bad based on the saliva ORP value; a step of providing information on lifestyle improvement that will lead to good health to subjects who have been determined to be in poor health, and having the subjects select information targets; In order to confirm the effectiveness of the lifestyle habit improvement information object by a monitor test, an ORP value, which is an oxidation-reduction potential, is measured by collecting saliva from the monitor before and after using the object; A step of determining the change and confirming in advance whether the ORP value of the saliva after using the object decreases in the negative potential direction or increases in the positive potential direction compared to the ORP value of the saliva before using the object; The subject of the lifestyle habit improvement information that is determined to lead to good health, and providing information to the subject in poor physical condition as an introduction option for lifestyle improvement.

2. In the monitor test, the building material that may lead to good physical condition was brought into contact with the skin of the monitor's human body, and the results were compared before and after the contact. A lifestyle improvement method for improving physical condition as described in claim 1, characterized in that the ORP value, which is the oxidation-reduction potential, is measured by collecting saliva from the monitor to determine its change, and the ORP value after the monitor touches the building material to the human body part is determined to be lower or higher in the negative potential direction than the ORP value before touching.

3. The monitor subjects were not wearing organic clothing made from natural materials that may improve their physical condition, such as cotton, hemp (plant fiber), linen, silk, wool, cashmere, alpaca, angora, mohair, camel, or organic cotton. Instead, a part of the organic clothing was placed in contact with the skin of the monitor's body, and the subjects' physical condition was measured before and after the contact. A lifestyle improvement method that leads to good physical condition, as described in claim 1, characterized in that the ORP value, which is the oxidation-reduction potential, is measured by collecting saliva from the monitor to determine the change, and the ORP value after the monitor touches the organic clothing to a human body part is determined to be lower or higher in the negative potential direction than the ORP value before touching.

4. A method for improving lifestyle habits that leads to good health as described in claim 1, characterized in that the monitor subject is asked to take a deep breath of oxygen (air) contributed by plants in response to photosynthesis in early morning sunlight, which may lead to good health, and the ORP value, which is the oxidation-reduction potential, is measured by collecting saliva from the monitor before and after taking the deep breath to determine the change, and the ORP value after the monitor takes the deep breath is determined to be lower or higher in the negative potential direction than the ORP value before taking the deep breath, thereby confirming in advance.

5. A method for improving lifestyle habits that leads to good health, as described in claim 1, characterized in that the monitor subject is given food products that have the potential to lead to good health and are grown without pesticides or chemical fertilizers, or are organic fruits and vegetables, and the ORP value, which is the oxidation-reduction potential, is measured by collecting saliva from the monitor before and after eating the food to determine the change, and the ORP value after the monitor eats the food products is determined to be lower or higher in the negative potential direction than the ORP value before eating, thereby confirming in advance.

6. A method for improving lifestyle habits that leads to good health, as described in claim 1, characterized in that the monitor subject is given a health food that has the potential to lead to good health, and the ORP value, which is the oxidation-reduction potential, is measured by collecting saliva from the monitor before and after eating the health food to determine the change, and the ORP value after the monitor eats the health food is determined to be lower or higher in the negative potential direction than the ORP value before eating it, thereby confirming in advance.

7. A method for improving lifestyle habits that leads to good health as described in claim 1, characterized in that the monitor subject is made to watch videos, listen to music, or appreciate art that may lead to good health, and the ORP value, which is the oxidation-reduction potential, is measured by collecting saliva from the monitor before and after watching the videos, listen to music, or appreciate art to determine the change, and the ORP value after the monitor watches the videos, listen to music, or appreciate art is determined to be lower or higher in the negative potential direction than the ORP value before watching the videos, listen to music, or appreciate art, thereby confirming in advance.

8. A lifestyle improvement method that leads to good health, as described in claim 1, characterized in that the subject who is determined to be in poor health is asked to ingest natural salt (natural salt) that has the potential to lead to good health, and the ORP value, which is the oxidation-reduction potential, is measured by collecting saliva from the monitor before and after the ingestion to determine the change, and the ORP value after the monitor ingests the natural salt (natural salt) is determined to be lower or higher in the negative potential direction than the ORP value before the ingestion, thereby confirming in advance.

9. The method for improving lifestyle habits that leads to good health, as described in claim 1, characterized in that the subject who is determined to be in poor health is asked to consume drinking water that has the potential to lead to good health, and the ORP value, which is the oxidation-reduction potential, is measured by collecting saliva from the monitor before and after the ingestion to determine the change, and the ORP value after the monitor has consumed the drinking water is determined to be lower or higher in the negative potential direction than the ORP value before the ingestion, thereby confirming in advance.

10. 2. The method for improving lifestyle habits that leads to good health according to claim 1, wherein the monitor subject is allowed to touch a personal ornament that may lead to good health to the skin of a part of the monitor's body, and the ORP value, which is the oxidation-reduction potential, is measured by collecting saliva from the monitor before and after the touch to determine the change, and the ORP value after the monitor touches the personal ornament to the part of the monitor's body is determined by determining whether the ORP value increases or decreases in the negative potential direction compared to the ORP value before the touch, thereby confirming in advance.

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