Method for controlling harmful annelids using natural pyrethrins

Abstract

The present invention addresses the problem of providing a method for controlling a harmful annelid by applying a natural pyrethrin. The present invention provides a method for controlling a harmful annelid, the method being characterized by applying an effective amount of a natural pyrethrin to the harmful annelid, a habitat of the harmful annelid or a place where the occurrence of the harmful annelid is predicted.

Description

[Technical Field]

[0001] This patent application claims priority under the Paris Convention to and the benefit of Japanese Patent Application No. 2020-217328 (filed December 25, 2020), the entire contents of which are incorporated herein by reference.

[0002] The present invention relates to a method for controlling harmful annelids using natural pyrethrins. [Background technology]

[0003] Various compounds have been investigated to date for the purpose of controlling harmful annelids. For example, Patent Document 1 describes deet and synthetic pyrethroids, particularly metofluthrin and transfluthrin, as repellent components for leeches. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2010-202629 Summary of the Invention [Problem to be solved by the invention]

[0005] However, while the conventional control methods mentioned above can repel harmful annelids approaching the human body, they are not suitable for eliminating harmful annelids from their habitats. Furthermore, even if they are repelled once, they are not killed, so their density in their habitat does not decrease, and once the repellent effect wears off, they will return to the human body or the area to be controlled.

[0006] Therefore, an object of the present invention is to provide a method for quickly exterminating harmful annelids from their habitats.

[0007] An object of the present invention is to provide a method for exterminating harmful annelids. [Means for solving the problem]

[0008] The present invention is as follows. [1] A method for exterminating harmful annelids, comprising applying an effective amount of natural pyrethrin to the harmful annelids, or to a place where the harmful annelids live or where they are expected to appear. [2] The method of [1], wherein the harmful annelid is a member of the class Hirudinida and order Arhynchobdellida. [3] The use of natural pyrethrins to control harmful annelids. [4] The harmful annelids are of the class Hirudinida and order Arhynchobdellida. [3] [Effects of the Invention]

[0009] According to the present invention, harmful annelids can be rapidly and effectively exterminated. DETAILED DESCRIPTION OF THE INVENTION

[0010] The natural pyrethrins (hereinafter sometimes referred to as "the present compounds") of the present invention are described below. Natural pyrethrins include six types of compounds: pyrethrin I, pyrethrin II, cinerin I, cinerin II, jasmoline I, and jasmoline II. Natural pyrethrins are typically obtained as an extract or as a dried powder of pyrethrum, which is obtained by extracting only the flower buds of pyrethrum (scientific names: Tanacetum cinerariifolium or Chrysanthemum cinerariaefolium) from the dried and pulverized flower buds using an appropriate solvent capable of dissolving the active ingredient, such as an organic solvent such as methanol. In addition to the six types of compounds, natural pyrethrins may also contain plant-derived impurities (such as fatty acids and flavonoids).In addition to the white daisy, plants from which natural pyrethrins can be obtained include Calendula officinalis, Chrysanthemum coccinum, Tagetes erecta, Tagetes minuta, Zinnia elegans, and Zinnia linnearis (Reference 1: Adnane, H. Alain, C. & Chantal, B. 2000. The Production of Pyrethrins by Plant Cell and Tissue Cultures of Chrysanthemum cinerariaefolium and Tagetes Species. Critical Reviews in Plant Sciences, 19(1):69-89; Reference 2: Kudakasseril, GJ and Staba, EJ 1988. Insecticidal phytochemicals. In: Cell Culture and Somatic Cell Genetics of Plants. pp. 537-552. Constabel, F. and Vasil, I.K., Eds., Academic Press, New York. Reference 3: John E. Casida, Gary B. Quistad. 1995. PYRETHRUM FLOWERS, Production, Chemistry, Toxicology, and Uses. pp. 123-125, Oxford University Press.) The plant species and varieties that serve as the source of the natural pyrethrins used in the present invention are not limited to those mentioned above. The plant cultivation method, cultivation conditions (weather, place of origin, soil type, etc.), harvest time, harvest part, harvesting method, washing method, extraction method, and purification method are not particularly limited. In addition, the natural pyrethrins used in the present invention also include, for example, natural pyrethrins obtained using a vector into which a gene encoding a pyrethrin biosynthetic enzyme has been inserted. The weight ratios of the six compounds in natural pyrethrins, pyrethrin I, pyrethrin II, cinerin I, cinerin II, jasmolin I, and jasmolin II, are not particularly limited and may be set at any weight ratio within the range of 0.001 to 99%, but are typically contained in weight ratios of 10 to 70% pyrethrin I, 10 to 70% pyrethrin II, 1 to 20% cinerin I, 1 to 20% cinerin II, 1 to 20% jasmolin I, and 1 to 20% jasmolin II. Specific examples of the blending ratios (parts by weight) are as follows: Weight ratio [pyrethrin I:pyrethrin II:cinerin I:cinerin II:jasmolin I:jasmolin II] = 38.0:35.0:7.3:11.7:4.0:4.0 (Reference 3) Furthermore, natural pyrethrins are usually plant extracts, and therefore may contain, in addition to the six compounds, plant-derived impurities and auxiliary ingredients such as solvents, stabilizers, etc. The content of the six compounds in natural pyrethrins is usually 10 to 99%, preferably 15 to 90%, and more preferably 20 to 85%. Examples of natural pyrethrins include those containing pyrethrin I (total amount of pyrethrin I, cinerin I, and jasmolin I) and pyrethrin II (total amount of pyrethrin II, cinerin II, and jasmolin II) in amounts of 20 to 40% pyrethrin I and 12 to 31% pyrethrin II.

[0011] The present compound can be mixed or used in combination with one or more components (hereinafter referred to as the present component) selected from the group consisting of the following groups (a), (b), (c), and (d): The term "mixed or combined use" means that the present compound and the present ingredient are used simultaneously, separately or with an interval of time. When the present compound and the present ingredient are used simultaneously, the present compound and the present ingredient may be contained in separate preparations or may be contained in a single preparation. One aspect of the present invention is a composition containing one or more components selected from the group consisting of group (a), group (b), group (c), and group (d), and the present compound (hereinafter referred to as composition A).

[0012] Group (a) includes acetylcholinesterase inhibitors (e.g., carbamate insecticides, organophosphate insecticides), GABAergic chloride channel blockers (e.g., phenylpyrazole insecticides), sodium channel modulators (e.g., pyrethroid insecticides), nicotinic acetylcholine receptor competitive modulators (e.g., neonicotinoid insecticides), nicotinic acetylcholine receptor allosteric modulators, glutamatergic chloride channel allosteric modulators (e.g., macrolide insecticides), juvenile hormone mimics, multisite inhibitors, chordotonal organ TRPV channel modulators, mite growth inhibitors, microbial insect midgut membrane disruptors, mitochondrial ATP synthase inhibitors, oxidative phosphorylation uncouplers, nicotinic acetylcholine receptor channel blockers (e.g., nereistoxin insecticides), chitin synthesis inhibitors, molting inhibitors, ecdysone receptor agonists, octopamine receptor agonists, mitochondrial electron transport chain complex I, II, The group consisting of inhibitors of genotypes III and IV, voltage-gated sodium channel blockers, acetyl-CoA carboxylase inhibitors, ryanodine receptor modulators (e.g., diamide insecticides), chordotonal organ modulators, microbial insecticides, and other insecticidal, acaricidal, and nematicidal active ingredients are described in the IRAC mechanism-based classification.

[0013] Group (b) is a group of synergists.

[0014] Group (c) is a group of repellent ingredients.

[0015] Group (d) is the group of molluscicidal ingredients.

[0016] The components described below are all known and can be obtained from commercially available preparations or produced by known methods. If the component is a microorganism, it can also be obtained from a bacterial depository. The numbers in parentheses represent the CAS RN (registered trademark).

[0017] Ingredients in group (a) above: Abamectin, acephate, acequinocyl, acetamiprid, acetoprole, acrinathrin, acinonapyr, afidopyropen, afoxolaner, alanycarb, aldicarb, allethrin, alpha-cypermethrin, alpha-endosulfan, aluminum phosphide, amitraz, azamethiphos, azinphos-ethyl, azinphos-methyl, azocyclotin, Bendiocarb, benfluthrin, benfuracarb, bensultap, benzoximate, benzpyrimoxan, beta-cyfluthrin, beta-cypermethrin, bifenazate, bifenthrin, bioallethrin, bioresmethrin, bistrifluron, borax, boric acid acid, broflanilide, bromopropylate, buprofezin, butocarboxim, butoxycarboxim, cadusafos, calcium phosphide, carbaryl, carbofuran, carbosulfan, cartap hydrochloridehydrochloride, cartap, chinomethionate, chlorantraniliprole, chlordane, chlorethoxyfos, chlorfenapyr, chlorfenvinphos, chlorfluazuron, chlormephos, chloropicrin, chlorpyrifos, chlorpyrifos-methyl, chromafenozide, clofentezine, clothianidin, concanamycin AA), coumaphos, cryolite, cyanophos, cyantraniliprole, cyclaniliprole, cyclobutrifluram, cycloprothrin, cycloxaprid, cyenopyrafen, cyetpyrafen, cyflumetofen, cyfluthrin, cyhalodiamide, cyhalothrin, cyhexatin, cypermethrin, cyphenothrin, cyproflanilide ide), cyromazine, dazomet, deltamethrin, demeton-S-methyl, diafenthiuron, diazinon, dichlorvos, dichloromezotiaz, dicofol, dicrotophos, diflovidazin, diflubenzuron, dimefluthrin, dimethoate, dimethylvinphos, dimpropyridaz, dinotefuran, disodium octaborate octaborate), disulfoton, DNOC (2-methyl-4,6-dinitrophenol), doramectin, emamectin benzoate, empenthrin, endosulfan, EPN (O-ethyl O-(4-nitrophenyl)phenylphosphonothioate, epsilon-metofluthrin, epsilon-momfluorothrin, esfenvalerate, ethifencarb, ethion, ethiprole, ethoprophos, etofenprox, etoxazole, famphur, fenamiphos, fenazaquin, fenbutatin oxideoxide, fenitrothion, fenobucarb, fenoxycarb, fenpropathrin, fenpyroximate, fenthion, fenvalerate, fipronil, flometoquin, flonicamid, fluacrypyrim, fluazaindolizine, fluazuron, flubendiamide, flucycloxuron, flucythrinate, fluensulfon e), flufenprox, flufenoxuron, flufiprole, flumethrin, flupentiofenox, flupyradifurone, flupirimin, fluralaner, fluvalinate, fluxametamide, formetanate, fosthiazate, furamethrin, furathiocarb, gamma-cyhalothrin, GS-omega / kappa HXTX-Hv1a peptide (GS-omega / kappa HXTX-Hv1apeptide), halfenprox, halofenozide, heptafluthrin, heptenophos, hexaflumuron, hexythiazox, hydramethylnon, hydroprene, imicyafos, imidacloprid, imidaclothiz, imiprothrin, indoxacarb, isocycloseram, isofenphos, isoprocarb, isopropyl-O-(methoxyaminothiophosphoryl) salicylate salicylate, isoxathion, ivermectin, kadethrin, kappa-tefluthrin, kappa-bifenthrin, kinoprene, lambda-cyhalothrin, lenoremycin, lepimectin, lime sulfur, lotilaner, lufenuron, machine oil oil), malathion, mecarbam, meperfluthrin, metaflumizone, metam, methamidophos, methidathion, methiocarb, methomyl, methoprene, methoxychlor, methoxyfenozide, methyl bromidebromide, metofluthrin, metolcarb, metoxadiazone, mevinphos, milbemectin, milbemycin oxime oxime, momfluorothrin, monocrotophos, moxidectin, naled, nicofluprole, nicotine, nicotine sulfate, nitenpyram, novaluron, noviflumuron, omethoate, oxamyl, oxazosulfyl, oxydemeton-methyl, parathion, parathion-methyl, permetrin permethrin, phenothrin, phenthoate, phorate, phosalone, phosmet, phosphamidon, phosphine, phoxim, pirimicarb, pirimiphos-methyl, prallethrin, profenofos, profluthrin, propargite, propetamphos, propoxur, propylene glycol arginateAlginate, prothiofos, piflubumide, pymetrozine, pyraclofos, pyridaben, pyridalyl, pyridaphenthion, pyrifluquinazone, pyrimidifen, pyriminostrobin, pyriprole, pyriproxyfen, quinalphos, resmethrin, rotenone, ryanodine, sarolaner, selamectin, sigma-cypermethrin, silafluofen, sodium borate borate, sodium metaborate, spinetoram, spinosad, spirodiclofen, spiromesifen, spiropidione, spirotetramat, sulfluramid, sulfotep, sulfoxaflor, sulfur, sulfuryl fluoride, tartaremetic, tau-fluvalinate, tebufenozide, tebufenpyrad, tebupirimfos, teflubenzuron, tefluthrin, temephos, terbufos, tetrachlorantraniliprole, tetrachlorvinphos, tetradifon, tetramethrin, tetramethylfluthrin, tetraniliprole, theta-cypermethrin, thiacloprid, thiamethoxam, thiocyclam hiocyclam, thiodicarb, thiofanox, thiometon, thiosultap disodium, thiosultap monosodium, tioxazafen, tolfenpyrad, tralomethrin, transfluthrin, triazamate, triazophos, trichlorfon, triflumezopyrim, triflumuron, trimethacarb, tyclopyrazoflor, vamidothion, XMC (3,5-dimethylphenyl N-methylcarbamate, xylylcarb, zeta-cypermethrin, zinc phosphidephosphide)、4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methyl-N-(1-oxothietan-3-yl)benzamide(1241050-20-3)、3-methoxy-N-(5-{5-(trifluoromethyl)-5-[3-(trifluoromethyl )phenyl]-4,5-dihydro-1,2-oxazol-3-yl}indan-1-yl)propanamide(1118626-57-5)、2-({2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl}imino)-3-(2,2,2-trifluoroethyl)-1,3-thiazolidin-4-one(1445683-71-5)、(3R)-3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-4-ium-5-olate(2249718-27-0)、N-{4-chloro-3-[(1-cyanocyclopropyl)carbamoyl]phenyl}-1-methyl-4-(methanesulfonyl)-3-(1,1,2,2,2-pentafluoroethyl)-1H-pyrazole-3-carboxamide(1400768-21-9)、11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one(907187-07-9)、3-(4'-fluoro-2,4-dimethyl[1,1'-biphenyl]-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one(1031385-91-7)、N-[3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl]-2-(methanesulfonyl)propanamide(2396747-83-2)、1,4-dimethyl-2-[2-(3-pyridinyl)-2H-indazol-5-yl]-1,2,4-triazolidine-3,5-dione(2171099-09-3)、2-isopropyl-5-[(3,4,4-trifluoro-3-buten-1-yl)sulfonyl]-1,3,4-thiadiazole(2058052-95-0)、N-({2-fluoro-4-[(2S,3S)-2-hydroxy-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}methyl)cyclopropanecarboxamide, BT crop protein Cry1Ab (BT crop protein Cry1Ab), BT crop protein Cry1Ac (BT crop protein Cry1Ac), BT crop protein Cry1Fa (BT crop protein Cry1Fa), BT crop protein Cry1a.105 (BT crop protein Cry1A.105), BT crop protein Cry2Ab (BT crop protein Cry2Ab), BT crop protein Vip3A (BT crop protein Vip3A), BT crop protein Cry3A (BT crop protein Cry3A), BT crop protein Cry3Ab (BT crop protein Cry3Ab), BT crop protein Cry3Bb (BT crop protein Cry3Bb, BT crop protein Cry34Ab1 / Cry35Ab1, Adoxophyes orana granulosis virus strain BV-0001, Anticarsia gemmatalis mNPV, Autographa californica mNPV, Cydia pomonella GV strain V15, Cydia pomonella GV strain V22, Cryptophlebia leucotreta granulosis virus GV), Dendrolimus punctatus cypovirus,Helicoverpa armigera NPV strain BV-0003, Helicoverpa zea NPV, Lymantria dispar NPV, Mamestra brassicae NPV, Mamestra configurata NPV, Neodiprion abietis NPV, Neodiprion lecontei NPV, Neodiprion sertifer NPV, Nosema locustae NPV, locustae), Orgyia pseudotsugata nucleopolyhedrovirus (Orgyia pseudotsugata NPV), Pieris rapae granulosis virus (Pieris rapae GV), Plodia interpunctella granulosis virus (Plodia interpunctella GV), Spodoptera exigua mNPV, Spodoptera littoralis mNPV, Spodoptera litura NPV, Arthrobotrys dactyloides, Bacillus firmus strain GB-126, Bacillus firmus strain I-1582, Bacillus megaterium, Bacillus sp. strain AQ175, Bacillus sp. strain AQ177, Bacillus sp. strain AQ178, Bacillus sphaericus strain 2362, Bacillus sphaericus strain ABTS1743, Bacillus sphaericus Serotype strain H5a5b,Bacillus thuringiensis strain AQ52、Bacillus thuringiensis strain BD#32、Bacillus thuringiensis strain CR-371、Bacillus thuringiensis subsp. Aizawai strain ABTS-1857、Bacillus thuringiensis subsp. Aizawai strain AM65-52、Bacillus thuringiensis subsp. Aizawai strain GC-91、Bacillus thuringiensis subsp. Aizawai Serotype strain H-7、Bacillus thuringiensis subsp. Kurstaki strain ABTS351、Bacillus thuringiensis subsp. Kurstaki strain BMP123、Bacillus thuringiensis subsp. Kurstaki strain EG234、Bacillus thuringiensis subsp. Kurstaki strain EG7841、Bacillus thuringiensis subsp. Kurstaki strain EVB113-19、Bacillus thuringiensis subsp. Kurstaki strain F810、Bacillus thuringiensis subsp. Kurstaki strain HD-1、Bacillus thuringiensis subsp. Kurstaki strain PB54、Bacillus thuringiensis subsp. Kurstaki strain SA-11、Bacillus thuringiensis subsp. Kurstaki strain SA-12、Bacillus thuringiensis subsp. Tenebriosis strain NB176、Bacillus thuringiensis subsp. Thuringiensis strain MPPL002、Bacillus thuringiensis subsp. morrisoni、Bacillus thuringiensis var. colmeri、Bacillus thuringiensis var. darmstadiensis strain 24-91 Bacillus thuringiensis var. dendrolimus、Bacillus thuringiensis var. galleriae、Bacillus thuringiensis var. israelensis strain BMP144 Bacillus thuringiensis var. israelensis serotype strain H-14 Bacillus thuringiensis var. japanensis strain buibui、Bacillus thuringiensis var. san diego strain M-7 Bacillus thuringiensis var. 7216. Bacillus thuringiensis var. aegypti、Bacillus thuringiensis var. T36 、Beauveria bassiana strain ANT-03 、Beauveria bassiana strain ATCC74040 、Beauveria bassiana strain GHA 、Beauveria brongniartii 、Burkholderia rinogensis strain A396 、Chromobacterium subtsugae strain PRAA4-1T Dactyllela ellipsospora Dactylaria thaumasia Hirsutella minnesotensis Hirsutella rhossiliensis Hirsutella thompsonii Lagenidium giganteum Lecanicillium lecanii strain KV01 Lecanicillium lecanii conidia of strain DAOM198499.Lecanicillium lecanii conidia of strain DAOM216596, Lecanicillium muscarium strain Ve6, Metarhizium anisopliae strain F52, Metarhizium anisopliae var. acridum, Metarhizium anisopliae var. anisopliae BIPESCO 5 / F52, Metarhizium flavoviride, Monacrosporium phymatopagum, Paecilomyces fumosoroseus Apopka strain 97, Paecilomyces lilacinus strain 251, Paecilomyces tenuipes strain T1, Paenibacillus popilliae, Pasteuria nishizawae strain Pn1, Pasteuria penetrans, Pasteuria usgae, Pasteuria thoynei, Serratia entomophila, Verticillium chlamydosporium, Verticillium lecani strain NCIM1312.

[0018] The main component of the above group (b): 1-dodecyl-1H-imidazole, N-(2-ethylhexyl)-8,9,10-trinorborn-5-ene-2,3-dicarboximide, bucarpolate, N,N-dibutyl-4-chlorobenzenesulfonamide, dietholate, diethylmaleate, piperonyl butoxide, piperonyl cyclonene, piprotal, propyl isomer isome), safroxan, sesamex, sesamolin, sulfoxide, verbutin, 1,1-bis(4-chlorophenyl)ethanol (DMC), 1,1-bis(4-chlorophenyl)-2,2,2-trifluoroethanol (FDMC), 1,2-epoxy-1,2,3,4-tetrahydronaphthalene (ETN), 1,1,1-trichloro-2,3-expoxypropane (ETP), phenylsaligenin cyclic phosphate (PSCP), S,S,S-tributyl phosphorotrithioate (TBPT), and triphenyl phosphate (TPP).

[0019] Ingredients in group (c) above: Anthraquinone, DEET, icaridin.

[0020] Ingredients in group (d) above: Bis(tributyltin) oxide, allicin, bromoacetamide, cloethocarb, copper sulfate, fentin, ferric phosphate, metaldehyde, niclosamide, pentachlorophenol, sodium pentachlorophenoxide, tazimcarb, tralopyril, and trifenmorph.

[0021] The ratio of the present compound to the present component is not particularly limited, and examples thereof include a weight ratio (present compound:present component) of 1000:1 to 1:1000, 500:1 to 1:500, 100:1 to 1:100, 50:1, 20:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:20, 1:50, and the like.

[0022] The present compound is effective against harmful annelids, such as the following:

[0023] Class Hirudinida, Order Rhynchobdellida Family Glossiphoniidae: Actinobdella annectens, Actinobdella inequiannulata, Actinobdella magnidisca, Actinobdella pediculata, Alboglossiphonia heteroclite, Desserobdella cryptobranchii, Desserobdella michiganensis, Desserobdella phalera, Desserobdella picta, Gloiobdella elongate, Glossiphonia complanata, Glossiphonia paludosa, Glossiphonia swampina, Glossiphonia verrucata, Haementeria officinalis, Haementeria tuberculifera, Helobdella adiastola, Helobdella californica, Helobdella conchata, Helobdella fusca, Helobdella moorei, Helobdella nigropunctata, Helobdella papillata, Helobdella punctatolineata, Helobdella robusta, Helobdella stagnalis, Helobdella transversa, Helobdella triserialis, Marvinmeyeria lucida, Oligobdella biannulata, Placobdella bistriata, Placobdella hollensis, Placobdella mexicana, Placobdella montifera, Placobdella multilineata, Placobdella nuchalis, Placobdella ornata, Placobdella papillifera, Placobdella parasitica, Placobdella translucens, Placobdelloides maorica, Theromyzon bifariumTheromyzon maculosum, Theromyzon rough,Theromyzon tessulatu,Theromyzon trizonare,Torix novaezealandiae;, Ozobranchus (Ozobranchidae): Ozobranchus branchiatus, Ozobranchus jantseanus, Ozobranchus margoi; Family Piscicolidae: Aestabdella abditovesiculata, Aestabdella leiostomi, Austrobdella californica, Baicalobdella torquata, Bdellamaris eptatreti, Beringobdella rectangulata, Branchellion borealis, Branchellion lobata, Branchellion ravenelii, Branchellion torpedinis, Calliobdella knightjonesi, Calliobdella lophii, Calliobdella nodulifera, Calliobdella vivid, Caspiobdella caspica, Caspiobdella fadejewi, Caspiobdella tuberculate, Cystobranchus mammillatus, Cystobranchus meyeri, Cystobranchus moorei, Cystobranchus verrilli, Cystobranchus virginicus, Crangonobdella maculosa, Hemibdella branchiarum, Hemibdella rapax, Johanssonia arctica, Makarabdella manteri, Malmiana brunnea, Malmiana bubali, Malmiana diminuta, Malmiana philotherma, Malmiana scorpii, Malmiana virida, Malmiana yorki, Mysidobdella borealis, Myzobdella lugubris, Myzobdella patzcuarensis, Notobdella nototheniae, Notostomum cyclostomum, Notostomum leave, Oceanobdella microstoma, Oceanobdella pallida, Oceanobdella sexoculata, Orientobdella confluens,Ostreobdella papillata, Oxytonostoma typical, Piscicola geometra, Piscicola milneri, Piscicola punctata, Piscicola salmositica, Piscicola zebra, Piscicolaria reducta, Platybdella anarrhichae, Platybdella fabricii, Platybdella olriki, Platybdella quadrioculata, Pontobdella muricata, Pontobdella vosmaeri, Stibarobdella macrothela, Trachelobdella lubrica, Trachelobdella oregonensis, Trachelobdella livanovi; Hirudinida, Arhynchobdellida; Macrobdellidae: Macrobdella decora, Macrobdella diplotertia, Macrobdella ditetra, Macrobdella mimicus, Macrobdella sestertii, Oxyptychus antelarum, Oxyptychus bora, Oxyptychus brasilensis, Oxyptychus festai, Oxyptychus inexpectatus, Oxyptychus ornatus, Oxyptychus riporetensis, Oxyptychus strennus, Oxyptychus striatus, Philobdella floridana, Philobdella gracilis; Family Praobdellidae: Dinobdella ferox, Limnatis bacescui, Limnatis nilotica, Limnatis paluda, Limnobdella chiapasensis, Limnobdella mexicana, Limnobdella olivacea, Limnobdella profundisulcata, Limnobdella tehuacanea, Myxobdella africana, Myxobdella nepalica, Myxobdella sinanensis, Myxobdella weberi, Parapraobdella lineata, Pintobdella cajali, Praobdella buettneri, Praobdella guineensis, Praobdella maculate, Praobdella radiate, Tyrannobdella rex; Family Xerobdellidae: Diestecostoma magna, Diestecostoma mexicana, Diestecostoma octoannulata, Diestecostoma trujillensis, Mesobdella gemmate, Xerobdella anulata, Xerobdella lecomtei, Xerobdella praealpina; Family Hirudinidae: Hirudo medicinalis, Hirudo nipponia, Hirudo verbana, Hirudo orientalis, Hirudo sulukii, Hirudo troctina, Hirudinaria bpling, Hirudinaria javanica, Hirudinaria manillensis, Hirudobdella antipodum, Hirudobdella benhami, Ornithobdella edentula, Oxyuptychus antellarum, Poecilobdella blanchardi, Richardsonianus mauianus; Family Haemadipsidae: Haemadipsa agilis, Haemadipsa cavatuses, Haemadipsa cochiniana, Haemadipsa crenata, Haemadipsa dussumieri, Haemadipsa guangchuanensis, Haemadipsa hainana, Haemadipsa interrupta, Haemadipsa japonica, Haemadipsa kodairensis, Haemadipsa limuna, Haemadipsa montana, Haemadipsa moorei, Haemadipsa montivindicus, Haemadipsa ornata, Haemadipsa picta, Haemadipsa rjukjuana, Haemadipsa subagilis, Haemadipsa sumatrana, Haemadipsa sylvestris, Haemadipsa trimaculosa, Haemadipsa zeylanica, Chtonobdella aurita, Chtonobdella australis, Chtonobdella bilineata, Chtonobdella bilobata, Chtonobdella catenifera, Chtonobdella daubani, Chtonobdella fallax, Chtonobdella gloriosi, Chtonobdella grandidieri, Chtonobdella grandis, Chtonobdella jawarerensis, Chtonobdella kingi, Chtonobdella limbata, Chtonobdella lineata, Chtonobdella maculosa, Chtonobdella mediorubra, Chtonobdella meyeri, Chtonobdella minuta, Chtonobdella miranda, Chtonobdella molesta, Chtonobdella moluccensis, Chtonobdella morsitans, Chtonobdella niarchosorum,Chtonobdella nigra,Chtonobdella novabritanniae,Chtonobdella noxia,Chtonobdella nymboidae,Chtonobdella palmyrae,Chtonobdella papuensis,Chtonobdella parva,Chtonobdella pungens,Chtonobdella quoyi,Chtonobdella rennelli,Chtonobdella seychellensis,Chtonobdella singularis,Chtonobdella skottsbergi,Chtonobdella solomoni,Chtonobdella tanae,Chtonobdella tristriata,Chtonobdella vagans,Chtonobdella whitmani,Tritetrabdella kinabaluensis,Tritetrabdella longiducta,Tritetrabdella scandens,Tritetrabdella taiwana. ,

[0024] The present compound is usually mixed with an inactivated carrier such as a solid carrier, liquid carrier, or gaseous carrier and a surfactant, and formulation adjuvants such as binders, dispersants, and stabilizers are added as needed to formulate it into an aqueous suspension, oil suspension, oil solution, emulsifiable concentrate, emulsion formulation, microemulsion formulation, microcapsule formulation, wettable powder, water dispersible granule, dust, granule, tablet, aerosol, hand spray, resin formulation, etc. In addition to these formulations, the compound can also be formulated into the dosage forms described in the Manual on development and use of FAO and WHO Specifications for pesticides, FAO Plant Production and Protection Papers 271-276, prepared by the FAO / WHO Joint Meeting on Pesticide Specifications, 2016, ISSN: 0259-2517. These preparations usually contain the present compound or composition A in an amount of 0.0001 to 99% by weight.

[0025] Examples of solid carriers include clay (pyrophyllite clay, kaolin clay, etc.), talc, calcium carbonate, diatomaceous earth, zeolite, bentonite, acid clay, attapulgite, white carbon, ammonium sulfate, vermiculite, perlite, pumice, silica sand, fine powder and granular chemical fertilizers (ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, ammonium chloride, etc.), and resins (polypropylene, polyester, polyurethane, polyamide, polyvinyl chloride, etc.).

[0026] Examples of liquid carriers include water, alcohols (ethanol, cyclohexanol, benzyl alcohol, propylene glycol, polyethylene glycol, etc.), ketones (acetone, cyclohexanone, etc.), aromatic hydrocarbons (xylene, phenylxylylethane, methylnaphthalene, etc.), aliphatic hydrocarbons (hexane, cyclohexane, etc.), esters (ethyl acetate, methyl oleate, propylene carbonate, etc.), nitriles (acetonitrile, etc.), ethers (ethylene glycol dimethyl ether, etc.), amides (N,N-dimethylformamide, N,N-dimethyloctanamide, etc.), sulfoxides (dimethyl sulfoxide, etc.), lactams (N-methylpyrrolidone, N-octylpyrrolidone, etc.), and fatty acids (oleic acid, etc.).

[0027] Gaseous carriers include, for example, fluorocarbons, butane gas, LPG (liquefied petroleum gas), dimethyl ether, nitrogen, and carbon dioxide gas.

[0028] Examples of surfactants include nonionic surfactants (polyoxyethylene alkyl ethers, polyoxyethylene alkylaryl ethers, polyethylene glycol fatty acid esters, etc.) and anionic surfactants (alkyl sulfonates, alkylaryl sulfonates, alkyl sulfates, etc.).

[0029] Other formulation adjuvants include binders, dispersants, colorants, and stabilizers, and specific examples thereof include polysaccharides (starch, gum arabic, cellulose derivatives, alginic acid, etc.), lignin derivatives, synthetic water-soluble polymers (polyvinyl alcohol, polyvinylpyrrolidone, polyacrylic acids, etc.), acid isopropyl phosphate, and dibutylhydroxytoluene.

[0030] The method for controlling harmful annelids of the present invention is carried out by applying an effective amount of the present compound or composition A directly to the harmful annelids and / or to the habitat of the harmful annelids and / or to a place where they are expected to appear (plants, soil, inside or outside a house, an animal body, a human body, or clothing, a hat, or shoes).

[0031] As disclosed in the present invention, by directly spraying the present compound or composition A on harmful annelids, the harmful annelids can be rapidly exterminated and blood-sucking of humans or animals such as pets and livestock can be minimized.

[0032] As disclosed in the present invention, by spraying the present compound or composition A in the habitat of harmful annelids, the harmful annelids will come into contact with the sprayed surface and be killed, thereby preventing them from sucking blood from humans or animals such as pets and livestock.

[0033] As disclosed in the present invention, by spraying the present compound or composition A in the habitat of harmful annelids, it can exert an exterminating activity against harmful annelids for a certain period of time after spraying. Furthermore, depending on the formulation, it can disappear quickly from the environment after being sprayed, minimizing drug contamination in the environment.

[0034] As disclosed in the present invention, by applying the compound or composition A to the human body or the clothing or shoes of pets, harmful annelids will come into contact with the treated surface and be killed, thereby preventing blood-sucking on humans or animals such as pets and livestock.

[0035] As disclosed in the present invention, by applying the compound or composition A to the human body or to the clothing or shoes of pets, the compound or composition A can exert its exterminating activity against harmful annelids for a certain period of time after application. Furthermore, depending on the formulation, the compound or composition A can disappear from the environment quickly after application, minimizing chemical contamination in the environment.

[0036] When this compound is used to exterminate harmful annelids living on plants such as grass and weeds outdoors or on the ground, the application rate is 100mg / kg / day for a surface treatment area of 1 m. 2 When this compound is used to exterminate harmful annelids living in houses, the application amount is usually 0.01 to 1000 mg per square meter of treatment area. 2 The amount of this compound per square meter is usually 0.01 to 1,000 mg. When treating in an air space, the amount is 1 m 3 The amount of the present compound per unit area is usually 0.01 to 500 mg. When the present compound or Composition A is formulated as an emulsifiable concentrate, wettable powder, flowable powder, etc., it is usually applied after diluting with water so that the active ingredient concentration is 0.1 to 10,000 ppm, while oil solutions, aerosols, hand sprays, fumigants, poison baits, etc. are applied as is. [Example]

[0037] The present invention will be explained in more detail below with reference to formulation examples and test examples, but the present invention is not limited to these examples.

[0038] First, formulation examples of the present compound are shown below, where parts are by weight.

[0039] Formulation Example 1 A mixture of 35 parts of polyoxyethylene alkyl ether sulfate ammonium salt and silica (weight ratio 1:1), 10 parts of the present compound, and 55 parts of water is mixed and finely pulverized by wet pulverization to obtain a preparation.

[0040] Formulation Example 2 A preparation is obtained by grinding and mixing 50 parts of the present compound, 3 parts of calcium lignosulfonate, 2 parts of sodium lauryl sulfate, and 45 parts of silica.

[0041] Formulation Example 3 A preparation is obtained by mixing 5 parts of the present compound, 9 parts of polyoxyethylene styrylphenyl ether, 5 parts of polyoxyethylene decyl ether (number of ethylene oxide added: 5), 6 parts of calcium dodecylbenzenesulfonate, and 75 parts of xylene.

[0042] Formulation Example 4 Two parts of the present compound, one part of silica, two parts of calcium lignosulfonate, 30 parts of bentonite, and 65 parts of kaolin clay are pulverized and mixed, and an appropriate amount of water is added and kneaded. The mixture is granulated in a granulator and then dried to obtain a formulation.

[0043] Formulation Example 5 10 parts of this compound are mixed with a mixture of 18 parts of benzyl alcohol and 9 parts of DMSO (dimethyl sulfoxide), and 6.3 parts of GERONOL (registered trademark) TE250, 2.7 parts of Ethylan (registered trademark) NS-500LQ, and 54 parts of solvent naphtha are added thereto and mixed to obtain a formulation.

[0044] Formulation Example 6 0.1 parts of the present compound and 39.9 parts of kerosene are mixed and dissolved, placed in an aerosol container, and filled with 60 parts of liquefied petroleum gas (a mixture of propane, butane, and isobutane; saturated vapor pressure: 0.47 MPa (25°C)) to obtain a formulation.

[0045] Formulation Example 7 0.2 parts of the present compound, 50 parts of pyrethrum extract residue powder, 30 parts of Tabu powder, and 19.8 parts of wood flour are mixed, an appropriate amount of water is added, and the mixture is kneaded. The mixture is then extruded into a plate-shaped sheet, and then wound into a spiral shape using a die-cutting machine to obtain a formulation.

[0046] Next, the efficacy of the present compound against harmful annelids will be shown by test examples. In the following test examples, the tests were carried out at 25°C.

[0047] Test Method 1 Acetone solution prepared so that the test compound was 50 ppm was poured into a 20 mL container, and the test compound was 2.5 mg / m 2 The inner surface of the container is uniformly coated with the solution, and then dried. A leech (Haemadipsa zeylanica) approximately 1-3 cm in total length is placed in the container and the lid is closed. After a predetermined time has passed, the condition of the leech is examined and the mortality rate is calculated using the following formula. Individuals that do not respond normally to breath blowing on them (no active exploration, inability to walk, writhing around, lethargic and unresponsive, etc.) are considered dead. Mortality rate (%) = (number of deaths / number of test insects) × 100

[0048] Test Example 1-1 The results of the test carried out according to Test Method 1 are shown in Table 1. [Table 1] The total concentration of natural pyrethrins, pyrethrins I and II, was set at 50 ppm. This indicates that natural pyrethrins have a faster-acting extermination activity against harmful annelids than the repellent components described in Patent Document 1, such as deet, metofluthrin, or transfluthrin.

Claims

1. A method for exterminating harmful annelids, characterized by applying an effective amount of natural pyrethrin to the harmful annelids or their habitats or places where they are expected to appear, wherein the natural pyrethrins include pyrethrin I, pyrethrin II, cinerin I, cinerin II, jasmolin I, and jasmolin II.

2. 2. The method of claim 1, wherein the pest annelid is a member of the class Hirudinida, order Arhynchobdellida.

3. The method according to claim 1, wherein the amount of natural pyrethrins to be treated is 0.01 to 1000 mg per m 2 of treatment area.

4. 1. Use of natural pyrethrins for controlling harmful annelids, the natural pyrethrins including pyrethrin I, pyrethrin II, cinerin I, cinerin II, jasmolin I, and jasmolin II.

5. 5. The use according to claim 4, wherein the pest annelid is of the class Hirudinida, order Arhynchobdellida.

6. The use according to claim 4 or 5, wherein the amount of natural pyrethrins to be treated is 0.01 to 1000 mg per m 2 of treatment area.

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