Synergy pulse generating circuit, generating device and generating method

Abstract

A synergy pulse generating circuit, a generating device, and a generating method are provided. [Solution] The synergy pulse generating circuit includes a first power source, a first pulse generating module electrically connected to the first power source, a second power source, and a second pulse generating module electrically connected to the second power source. The first pulse generating module includes n stages of first pulse generating units that receive and store power supplied from the first power source. The x number of first pulse generating units that receive a first control signal discharge to form a first pulse that is applied to a load. The second pulse generating module includes m stages of second pulse generating units that receive and store power supplied from the second power source. The y number of second pulse generating units that receive a second control signal discharge to form a second pulse that is applied to a load. By selectively forming first pulses and / or second pulses with different widths and selecting the voltages of the first pulses and second pulses, the purpose of applying a composite pulse to a load can be achieved.

Description

[Technical Field]

[0001] This invention claims priority from Chinese patent application number CN202110921259.X entitled "Synergy pulse generating circuit, generating device and generating method thereof" and Chinese patent application number CN202110921262.1 entitled "Synergy pulse generating device, system and generating method thereof," the entire contents of which are incorporated herein by reference.

[0002] The present invention relates to pulse generation and medical device technology, and more particularly to a synergy pulse generation circuit, generator, and method. [Background technology]

[0003] Pulsed power technology is an electrical physics technology that rapidly compresses slowly accumulated high-density energy and converts it into a load or directly releases it. Since the development of this technology began, its main application fields have been in the military engineering and national defense fields, such as particle accelerators, electromagnetic pulse weapons, high-power laser generators, and new weapon research, which has promoted the rapid development of pulsed power technology.

[0004] In recent years, as the application of pulsed power technology has expanded to fields such as medicine, environmental science, isotope science, food processing, electromagnetic compatibility testing, and bioengineering, the requirements for pulse generators have also been changing.

[0005] Conventional pulsers usually can only generate pulse signals with a specific width, which cannot meet the complex application needs of pulse technology. Summary of the Invention [Problem to be solved by the invention]

[0006] The present invention aims to solve at least one of the above problems to some extent, and proposes a synergy pulse generating circuit, a generating device, and a generating method thereof that generate pulses of different widths to form even more pulse combinations. [Means for solving the problem]

[0007] According to a first aspect of the present invention, there is provided a synergy pulse generation circuit including a first power supply, a first pulse generation module electrically connected to the first power supply, a second power supply, and a second pulse generation module electrically connected to the second power supply. the first pulse generating module includes n (n is an integer equal to or greater than 1) stages of first pulse generating units configured to receive and store power supplied at a first voltage from a first power supply, and discharge the stored power when a first control signal is received, such that x (x is an integer equal to or greater than 1 and equal to or less than n) discharges of the first pulse generating units are generated upon receiving a first control signal to form first pulses to be applied to the load; the second pulse generating module includes m (m is an integer equal to or greater than 1) stages of second pulse generating units configured to receive and store power supplied at a second voltage from a second power supply, and to discharge the stored power when a second control signal is received, such that y (y is an integer equal to or greater than 1 and equal to or less than m) second pulse generating units are discharged upon receiving a second control signal to form second pulses to be applied to the load; The output terminals of the first pulse generating module and the second pulse generating module are arranged to be connected to the same load; The second voltage is greater than the first voltage, and the width of the second pulse is less than the width of the first pulse.

[0008] According to a second aspect of the present invention, there is provided a synergy pulse generator. The synergy pulse generator A synergy pulse generating circuit according to a first aspect of the present invention; and a control module electrically connected to the first pulse generation module and the second pulse generation module, respectively, configured to generate a first control signal and a second control signal based on input information, and to transmit the first control signal to the first pulse generation module and the second control signal to the second pulse generation module.

[0009] According to a third aspect of the present invention, there is provided a synergy pulse generation method for use in a synergy pulse generation circuit according to the first aspect of the present invention, the method comprising: an nth (n is an integer of 1 or more) stage first pulse generating unit included in the first pulse generating module receives and stores power supplied from a first power supply at a first voltage, and an mth (m is an integer of 1 or more) stage second pulse generating unit included in the second pulse generating module receives and stores power supplied from a second power supply at a second voltage higher than the first voltage; x (x is an integer of 1 or more and n or less) first pulse generating units receive a first control signal and discharge under the control of the first control signal to form a first pulse; y second pulse generating units (y is an integer of 1 or more and m or less) receive second control signals and discharge under control of the second control signals to form second pulses; applying a first pulse and / or a second pulse to the load; The width of the second pulse is less than the width of the first pulse.

[0010] In some embodiments, the time at which the second pulse generator receives the second control signal is different from the time at which the first pulse generator receives the first control signal.

[0011] The beneficial technical effects of the technical solutions according to the embodiments of the present invention are that the synergistic pulse generating circuit, generator, and generating method according to the embodiments of the present invention can selectively form a first pulse and / or a second pulse with different widths, and by selecting the voltages of the first pulse and the second pulse, the purpose of applying a composite pulse to a load can be achieved. When the synergistic pulse generating circuit, generator, and generating method according to the present invention are used in an electroporation device for tumor treatment, for example, when the load is tumor cells, the role of the composite pulse is advantageous in enhancing the ablation effect on the tumor cells. [Brief explanation of the drawings]

[0012] [Figure 1]FIG. 1 is a diagram showing the configuration of a synergy pulse generating circuit according to an embodiment of the present invention. [Figure 2] FIG. 10 is a diagram showing the configuration of another synergy pulse generating circuit according to an embodiment of the present invention. [Figure 3] FIG. 10 is a diagram showing the configuration of another synergy pulse generating circuit according to an embodiment of the present invention. [Figure 4] 1 is a diagram showing the configuration of a synergy pulse generating device according to an embodiment of the present invention; [Figure 5] FIG. 1 is a diagram showing a flow of a synergy pulse generation method according to an embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0013] The above and / or additional aspects and advantages of the present invention will become apparent from the following description of the embodiments through the drawings. The present invention will be described in detail below. An example of an embodiment of the present invention is shown in the drawings, and identical or similar elements or identical or similar elements are represented by the same or similar reference numerals from the beginning in the drawings. Note that a detailed description of the illustrated features of the present invention is omitted because it is not necessary to describe known techniques. The embodiment described below with reference to the drawings is an example and does not limit the present invention.

[0014] Those skilled in the art will recognize that unless otherwise defined, all terms (including technical and scientific terms) used herein are the same as commonly understood by those of ordinary skill in the art to which this invention pertains. Terms such as general dictionary terms should be interpreted as meanings that are consistent with the meanings in the conventional context, and should not be construed as referring to ideal or formal meanings unless specifically defined as herein.

[0015] Those skilled in the art will understand that the singular terms "a," "one," "the," and "the" as used herein also include the plural unless otherwise specified. It should be noted that the term "comprising" in the present specification means that features, integers, steps, operations, elements, and / or modules are present, but does not exclude the presence or addition of other features, integers, steps, operations, elements, modules, and / or combinations thereof.

[0016] In recent years, as the application of pulsed power technology has expanded to fields such as medicine, environmental science, isotope science, food processing, electromagnetic compatibility testing, and bioengineering, the requirements for pulse generators have also been changing.

[0017] Taking the medical field as an example, the inventors of the present invention have discovered that when using electroablation technology to ablate tumor cells, a combination of pulses with different pulse widths can sometimes achieve a better ablation effect than a single pulse. For example, when a microsecond pulse is applied to tumor cells, it has a large ablation area but a low ablation rate for tumor cells, especially malignant tumor cells with high distortion, while when a nanosecond pulse is applied to tumor cells, it has a high ablation rate but a small ablation area. The combined use of a microsecond or millisecond pulse and a nanosecond pulse can significantly improve the ablation effect of tumor cells. In addition to ablation of tumor cells by reversible electroporation induced by a nanosecond pulse, applying a microsecond or millisecond pulse in combination during the duration of irreversible electroporation induced by a nanosecond pulse can also perforate the cell membrane, allowing the electric field of the microsecond or millisecond pulse to penetrate into the cell interior and further induce apoptosis. This results in a higher ablation effect than when a single nanosecond, microsecond, or millisecond pulse is applied. To generate the synergistic pulse, a corresponding pulse generator is required, whereas the conventional pulse generator can only generate pulse signals with a specific width, and cannot meet the complex application needs of pulses.

[0018] The present invention proposes a synergy pulse generating circuit, a generating device, and a generating method thereof, which aim to solve at least one of the above problems to some extent.

[0019] The following provides a detailed description of the technical solution of the present invention and how the technical problem is solved by the technical solution of the present invention through specific examples.

[0020] As shown in FIG. 1, an embodiment of the present invention provides a synergy pulse generation circuit including a first power supply U1, a first pulse generation module 1 electrically connected to the first power supply U1, a second power supply U2, and a second pulse generation module 2 electrically connected to the second power supply U2.

[0021] The first pulse generating module 1 has n (n is an integer greater than or equal to 1) stages of first pulse generating units 11, and the first pulse generating units 11 receive and store power supplied at a first voltage from a first power supply U1, and upon receiving a first control signal, release the stored amount of power. Upon receiving the first control signal, x (x is an integer greater than or equal to 1 and less than or equal to n) first pulse generating units 11 discharge to form a first pulse to be applied to the load 3.

[0022] The second pulse generating module 3 has m (where y is an integer greater than or equal to 1) stages of second pulse generating units 21, and the second pulse generating units 21 receive and store power supplied at a second voltage from a second power supply U2, and upon receiving a second control signal, release the stored amount of power. Upon receiving the second control signal, y (where y is an integer greater than or equal to 1 and less than or equal to m) second pulse generating units 21 discharge to form a second pulse that is applied to the load 3.

[0023] In some embodiments, the second voltage is greater than the first voltage and the width of the second pulse is less than the width of the first pulse. In some embodiments, the time at which the second pulse generating unit 21 receives the second control signal is different from the time at which the first pulse generating unit 11 receives the first control signal.

[0024] Theoretically, each of the x first pulse generating units 11 that receive the first control signal discharges at the first voltage. However, in reality, due to factors such as the equivalent impedance of each element in the pulse generating circuit, the discharge voltage of each first pulse generating unit 11 is slightly lower than the first voltage, but the difference between the first voltage and the first voltage is small. Therefore, the voltage of the first pulse applied to the load 3 can be approximated by x times the first voltage. Similarly, the voltage of the second pulse applied to the load 3 can be approximated by y times the second voltage. For convenience of explanation, in the examples described below, interpretation and explanation of the actual voltage values ​​of the first pulse generating units 11 and second pulse generating units 21 during discharge will be omitted, and all will be described as the first voltage and the second voltage. Based on the above, the voltage of the first pulse and the voltage of the second pulse can be adjusted by setting the number of first pulse generating units 11 and second pulse generating units 21 that discharge simultaneously.

[0025] The time when the second pulse generating unit 21 receives the second control signal is different from the time when the first pulse generating unit 11 receives the first control signal. When the second pulse generating unit 21 receives the second control signal, the first pulse generating unit 11 does not receive the first control signal. However, when the first pulse generating unit 11 receives the first control signal, the second pulse generating unit 21 does not receive the second control signal. In other words, the first pulse and the second pulse are not generated simultaneously, and the first pulse and the second pulse do not interfere with each other.

[0026] Different pulse combinations can be formed by setting the first control signal and the second control signal differently. For example, in one specific embodiment, the pulse group includes a plurality of first pulse groups, where two adjacent first pulse groups are spaced apart by a time t1, each first pulse group includes a number of first pulses, and two adjacent first pulses are spaced apart by a time t2. In another specific embodiment, the pulse group includes a plurality of second pulse groups, where two adjacent second pulse groups are spaced apart by a time t3, each second pulse group includes b number of second pulses, and two adjacent second pulses are spaced apart by a time t4. In another specific embodiment, the pulse combination includes a plurality of first pulses and a plurality of second pulses. The first pulses and second pulses may be applied alternately to the load 3, or the second pulse may be applied to the load 3 after all first pulses have been applied to the load 3. Alternatively, a second pulse is applied to the load 3 after all of the second pulses have been applied to the load 3. These first pulses may form a plurality of first pulse groups, and these second pulses may form a plurality of second pulse groups. The first pulse groups and the second pulse groups are applied to the load 3 alternately.

[0027] The synergy pulse generating circuit of this embodiment selectively generates a first pulse and / or a second pulse with different widths and can select the voltages of the first and second pulses, thereby achieving the purpose of applying a composite pulse to the load 3. The widths of the first and second pulses can be controlled by setting the control signal. Depending on the requirements for different pulse voltages, those skilled in the art can configure the voltages of the first and second power supplies and the number of stages in the pulse generating unit in correspondence with each other so that the output pulse voltage falls within the desired voltage range.

[0028] For convenience of explanation, the signal output by the synergy pulse generating circuit of the present invention is also called a synergy pulse or a composite pulse.

[0029] For example, if the load 3 is tumor tissue, the combined pulse action is advantageous for enhancing the ablation effect on tumor cells. Here, the first pulse may be a millisecond pulse or a microsecond pulse, and the second pulse may be a nanosecond pulse. For example, if a microsecond pulse and a nanosecond pulse are combined, the voltage of the first pulse may be on the order of several kilovolts, and the voltage of the nanosecond pulse may be on the order of several tens of kilovolts. For example, if the voltage of the nanosecond pulse is 15 kV and the second voltage source is 750 V, a 20-stage pulse generator can achieve an output of 15 kV.

[0030] In the above embodiment, the frames that can be selected by the synergy pulse generating circuit are described. In the following embodiment, the configuration of the first pulse generating unit 11 in each stage in the first pulse generating module 1 and the connection relationship to the first pulse generating unit 11 in each stage, as well as the configuration of the second pulse generating unit 21 in each stage in the second pulse generating module 2 and the connection relationship to the second pulse generating unit 21 in each stage will be described in detail.

[0031] In one preferred embodiment, as shown in FIG. 2, the first pulse generating unit 11 in the synergy pulse generating circuit includes a first memory unit 111, a first switch unit 112, and a first off unit 113, and the second pulse generating unit 21 includes a second memory unit 211, a second switch unit 212, and a second off unit 213.

[0032] 2, the first switch unit 112 is arranged to be turned on under control of the first control signal so as to connect in series each of the first memory units 111 in the same stage as the first switch unit 112 that has received the first control signal to form a first pulse and discharge the connected units. As shown in FIG. 2, the first off unit 113 is arranged so that only a current flows from the first power supply U1 to the first pulse generating unit 11, or a current flows from the first pulse generating unit 11 of the current stage to the first pulse generating unit 11 of the next stage.

[0033] Specifically, when discharging, only the first switch unit 112 that receives the first control signal turns on, and at the same time, the one-way off action of the first off unit 113 causes the first memory units 111 in the first pulse generation unit 11 that received the first control signal to be connected in series and discharge is performed. During discharge, the first memory units 111 correspond to one power source, and these series-connected power sources simultaneously discharge at a first voltage, and when x first memory units 111 out of the n stages of first memory units 111 are connected in series and discharge, the voltage of the formed first pulse becomes x times the first voltage.

[0034] 2, the second switch unit 212 is turned on by control of the second control signal, and the second switch unit 212 that receives the second control signal and the second memory units 211 at the same stage are connected in series to discharge and form a second pulse, and the second off unit 213 is arranged to pass current only from the second power supply U2 to the second pulse generating unit 21. Alternatively, current flows from the second pulse generating unit 21 at the current stage to the second pulse generating unit 21 at the next stage.

[0035] 2, the second switch unit 212 is arranged to be turned on under control of the second control signal so as to serially connect and discharge the second storage units 211 in the same stage as the second switch unit 212 that has received the second control signal to form a second pulse. The second off unit 213 is arranged so that only current flows from the second power supply U2 to the second pulse generating unit 21, or flows from the second pulse generating unit 21 of the current stage to the second pulse generating unit 21 of the next stage.

[0036] Specifically, when discharging, only the second switch unit 212 that receives the second control signal turns on. At the same time, the one-way off action of the second off unit 213 causes the second memory units 211 in the second pulse generating unit 21 that receive the second control signal to be connected in series and discharged. The second memory units 211 correspond to one power supply during discharging, and these series-connected power supplies simultaneously discharge at the second voltage. Of the m stages of second memory units 211, y second memory units 211 are connected in series and discharged. The voltage of the generated second pulse is y times the second voltage.

[0037] 2, the first switch unit 112 is configured to be turned off when a third control signal is received, thereby connecting the first storage unit 111 of each stage in parallel to the first power supply U1 to receive and store power supplied from the first power supply U1. The second switch unit 212 is configured to be turned off when a fourth control signal is received, thereby connecting the second storage unit 211 of each stage in parallel to the second power supply U2 to receive and store power supplied from the second power supply U2.

[0038] Specifically, when the first switch unit 112 is in the off state, the first memory units 111 of each stage are connected in parallel due to the one-way off action of the first off unit 113, and the power supplied from the first power supply U1 is stored at the first voltage. Similarly, the second memory units 211 of each stage are connected in parallel, and the power supplied from the first power supply U1 is stored at the first voltage.

[0039] In one specific embodiment, as shown in FIG. 3, in the synergy pulse generating circuit, the first off unit 113 includes a first off element and a second off element. The first off element of the first stage is electrically connected to a first end of the first power supply U1 and a first end of the first memory unit 111 of the first stage. The first off element of the i-th stage (i is an integer greater than or equal to 2) is electrically connected to a first end of the first memory unit 111 of the i-1-th stage, a first end of the first memory unit 111 of the i-th stage, and a first off element of the i-1-th stage. The second off element of each stage is electrically connected to a second end of the first memory unit 111 of the current stage, a second end of the first switch of the current stage, and a second off element of the next stage.

[0040] As shown in FIG. 3 , in the synergy pulse generating circuit, the second off unit 213 includes a third off element and a fourth off element. The third off element of the first stage is electrically connected to a first end of the second power supply U2 and a first end of the second memory unit 211 of the first stage. The third off element of the j-th stage (j is an integer greater than or equal to 2) is electrically connected to a first end of the second memory unit 211 of the j-1-th stage, a first end of the second memory unit 211 of the j-th stage, and the third off element of the j-1-th stage. The fourth off element of each stage is electrically connected to a second end of the second memory unit 211 of the current stage, a second end of the second switch of the current stage, and the fourth off element of the next stage.

[0041] 3, both ends of the first memory unit 111 of each stage are electrically connected to both ends of the first power supply U1. The control end of the first switch unit 112 of each stage receives a first control signal, and is arranged so that the first end and the second end of the first switch unit 112 of each stage are electrically connected to the first end of the first memory unit 111 of the current stage and the second end of the first memory unit 111 of the next stage, respectively. Both ends of the second memory unit 211 of each stage are electrically connected to both ends of the second power supply U2. The control end of the second switch unit 212 of each stage receives a second control signal, and is arranged so that the first end and the second end of the second switch of each stage are electrically connected to the first end of the second memory unit 211 of the current stage and the second end of the second memory unit 211 of the next stage, respectively.

[0042] In some specific embodiments, the first memory unit 111 includes a first capacitor, and the second memory unit 211 includes a second capacitor. The first switch unit 112 includes a first solid-state switch element, and the second switch unit 212 includes a second solid-state switch element. The first off element includes a first diode, the second off element includes a second diode, the third off element includes a third diode, and the fourth off element includes a fourth diode. That is, a capacitor is used as the memory element, a solid-state switch element is used as the switch element, and a diode is used as the off element. The solid-state switch element can be realized based on a MOSFET (Metal Oxide Semiconductor Field Effect Transistor), an IGBT (Insulated Gate Bipolar Transistor), a triode, or the like.

[0043] 3, in the pulse generating circuit, the first pulse generating module 1 includes four stages of first pulse generating sections 11, and the second pulse generating module 2 includes three stages of second pulse generating sections 21, where n is 4 and m is 3. Note that this is merely an example and does not limit the number of stages of first pulse generating sections 11 in the first pulse generating module 1 or the number of stages of second pulse generating sections 21 in the second pulse generating module 2.

[0044] As shown in FIG. 3, the first switch units 112 in the first to fourth stages, that is, the first solid-state switch elements in the first to fourth stages, are respectively solid-state switch elements S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 The first switch memories of the first to fourth stages are connected to the capacitors C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 The first off elements of the first to fourth stages are diodes D 1-1 , diode D 1-2, diode D 1-3 and diode D 1-4 The second off elements of the first to fourth stages are diodes D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 is

[0045] As shown in FIG. 3, the second switch units 212 of the first to fourth stages, i.e., the second triodes of the first to fourth stages, are respectively constituted by solid-state switch elements S 2-1 , solid-state switching element S 2-2 , solid-state switching element S 2-3 , and a solid-state switching element S 2-4 The first to fourth second storage units 211 are connected to the capacitors C 2-1 , capacitor C 2-2 , capacitor C 2-3 and capacitor C 2-4 The third off elements of the first to fourth stages are diodes D 3-1 , diode D 3-2 , diode D 3-3 and diode D 3-4 The fourth elements of the first to fourth stages are turned off, respectively, by the diodes D 4-1 , diode D 4-2 and diode D 4-3 is.

[0046] As shown in FIG. 3, the synergy pulse generating circuit includes a first power supply U1 connected to a first storage unit 111, i.e., a capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 When charging to 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 On the other hand, the second power supply U2 supplies a current to the second storage unit 211 via the capacitor C 2-1 , capacitor C 2-2 , capacitor C2-3 When charging to the fourth off part, that is, the diode D 4-1 , diode D 4-2 , diode D 4-3 Current flows through.

[0047] As shown in FIG. 3, the synergy pulse generating circuit includes a capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 , capacitor C 1-4 When the diode D 4-1 , diode D 4-2 , diode D 4-3 Current flows through capacitor C 2-1 , capacitor C 2-2 , capacitor C 2-3 When discharged, diode D 4-1 , diode D 4-2 , diode D 4-3 operates in the reverse off state.

[0048] In the synergy pulse generating circuit of this embodiment, the first pulse generating module 1 and the second pulse generating module 2 can not only realize the generation of composite pulses, but also reduce the wiring space, that is, a circuit board with a smaller area can be used as a carrier for the synergy pulse generating circuit of this embodiment.

[0049] As shown in FIG. 3, the first power supply U1 and the second power supply U2 are both constant voltage power supplies, and the solid-state switching element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 receives the third control signal, the solid-state switch element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 and solid-state switch element S 1-4 Both diodes are in the off state. 1-1 , diode D 1-2 , diode D 1-3and diode D 1-4 , diode D 2-1 , diode D 2-2 and diode D 2-3 Each of these has a unidirectional on function. 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 are in a parallel connection relationship and are electrically connected to the first terminal and the second terminal of the first power supply U1, that is, they are both electrically connected to the positive and negative terminals of the first power supply U1. When charging is completed, the capacitor C 1-1 , capacitor C 1-2 and capacitor C 1-3 The potential difference between both ends of each is the first voltage.

[0050] Similarly, the solid-state switching element S 2-1 , solid-state switching element S 2-2 and solid-state switch element S 2-3 When the fourth control signal is received, the capacitor C 2-1 , capacitor C 2-2 and capacitor C 2-3 are in a parallel connection relationship and are electrically connected to the first and second terminals of the second power supply U2, i.e., the positive and negative terminals of the second power supply U2, respectively. When charging is completed, the capacitor C 2-1 , capacitor C 2-2 and capacitor C 2-3 The potential difference between both ends of the two terminals is the second voltage.

[0051] As shown in Figure 3, the solid-state switch element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 When both of them receive the first control signal, the solid-state switch element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 and solid-state switch element S 1-4 Both diodes are in the on state. 1-1 , diode D1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 has a one-way on function, so the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 are in series, and the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 are discharged simultaneously. In addition, since the discharge voltages are both the first voltage, the voltage of the formed pulse is four times the first voltage.

[0052] Similarly, the solid-state switching element S 2-1 , solid-state switching element S 2-2 and solid-state switch element S 2-3 When any of the solid-state switch elements S 2-1 , solid-state switching element S 2-2 and solid-state switch element S 2-3 are both in the on state. 2-1 , capacitor C 2-2 and capacitor C 2-3 are in series, and the capacitor C 2-1 , capacitor C 2-2 and capacitor C 2-3 discharge simultaneously, and the discharge voltages are both the second voltage, so the voltage of the formed second pulse is four times the second voltage.

[0053] 3, in the synergy pulse generating circuit, each of the first off-elements in the second to n-th stages includes one first diode, each of the second off-elements in each stage includes one second diode, and the reverse breakdown voltages of the first diode and the second diode are both greater than the first voltage. Each of the third off-elements in the second to m-th stages includes one third diode, and each of the fourth off-elements in each stage includes one fourth diode, and the reverse breakdown voltages of the third diode and the fourth diode are both greater than the second voltage. The first off-element in the first stage includes s first diodes, and s times the reverse breakdown voltage of the first diode is greater than (n-1) times the first voltage. The third off-elements of the first stage include t third diodes, and s times the reverse breakdown voltage of the third diodes is greater than (m-1) times the second voltage, where s is an integer equal to or greater than 1, and t is an integer equal to or greater than 1.

[0054] Taking the synergy pulse generating circuit shown in Figure 3 as an example, the first pulse generating module 1 includes a four-stage first pulse generating unit 11, and the second pulse generating module 2 includes a three-stage second pulse generating unit 21. If the parameters of all the diodes serving as turn-off elements are the same, the first voltage will be smaller than the second voltage. Therefore, to ensure that each diode can normally perform its one-way turn-off function, the second voltage should be used as the basis for selection. For example, if the second voltage is 1000V, the reverse breakdown voltage of each diode should be greater than 1000V.

[0055] As shown in Figure 3, if the first voltage is 200V, the second voltage is 1000V, and the ground level is 0V, the reverse breakdown voltage of each diode is 1100V. During the discharge process of the first pulse transmitting module, the solid-state switching element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 and solid-state switch element S 1-4 If both are on, the capacitor C 1-1The voltage at one end connected to the positive terminal of the first power supply U1 is 800V. 1-1 If the differential pressure across the diode D is 800V, 1-1 When the first voltage is 500 V, the solid-state switching element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 and solid-state switch element S 1-4 When both of these are in the ON state, the capacitor C connected to the positive terminal of the first power supply U1 1-1 The voltage at one end of the diode D 1-1 If the differential voltage across the two diodes D 1-1 It is sufficient to set it as follows.

[0056] Similarly, if the second voltage is 1000V, the ground level is 0V, the reverse breakdown voltage of each diode is 1100V, and the solid-state switch element S 2-1 , solid-state switching element S 2-2 , solid-state switching element S 2-3 When both of these are turned on, the capacitor C connected to the positive terminal of the second power supply U2 2-1 The voltage at one end of the diode D 3-1 The differential voltage across both ends of the diode D 3-1 It is necessary to set up

[0057] 3, the pulse generating circuit according to the embodiment of the present invention may further include a first earth-fault module 4 and a second earth-fault module 5. The first earth-fault module 4 is electrically connected to the first pulse generating module and ground, respectively, and is configured to establish electrical continuity between the first pulse generating module and ground under control of a first earth-fault signal to discharge residual power in the first pulse generating module. The second earth-fault module 5 is electrically connected to the second pulse generating module and ground, respectively, and is configured to establish electrical continuity between the second pulse generating module and ground under control of a second earth-fault signal to discharge residual power in the second pulse generating module.

[0058] In some embodiments, the pulse generation circuit further includes a trigger unit 61 electrically connected to each of the first pulse generation module and the second pulse generation module, and at least a pair of electrodes 62 electrically connected to the trigger unit 61, the electrodes 62 being for contacting the load 3. The trigger unit 61 is configured to be turned on when triggered by a trigger command and to transmit the first pulse signal and / or the second pulse signal to the electrodes 62.

[0059] In some embodiments, the pulse generation circuit further includes an associated switch 63 associated with the trigger unit 61. Specifically, when the synergy pulse generation circuit in this embodiment is applied to a medical device, such as an electrical ablation device, the associated switch 63 may be a foot switch.

[0060] In some embodiments, there are multiple pairs of electrodes 62, and the pulse generation circuitry further includes a multiplexing unit 64. The multiplexing unit 64 may convert a single signal into a multiplexed signal to fit the multiple pairs of electrodes. Two identical signals are required for each electrode 62.

[0061] In some embodiments, the pulse generation circuit further includes a monitor module that monitors the voltage output by the first pulse signal and / or the second pulse signal and / or the current output by the first pulse signal and / or the second pulse signal. The monitor module includes a resistor 7, a first monitor unit 81, and a second monitor unit 82. The resistor 7 is electrically connected to the first pulse generation module, the second pulse generation module, and ground, respectively, and the first pulse signal and / or the second pulse signal may be applied to the resistor 7. The first monitor unit 81 is configured to monitor the current of the first pulse signal and / or the second pulse signal, and the second monitor unit 82 is configured to monitor the voltage applied to the resistor 7 by the first pulse signal and / or the second pulse signal. Of course, only one of the monitor units may be used to monitor either the output voltage or the current of the synergy pulse signal. For example, only the first monitor unit 81 is used, and in this case, the first monitor unit 81 can be configured as a voltage sensor or a current sensor.

[0062] The first monitor unit 81 includes a first Pearson coil, and the second monitor unit 82 includes a second Pearson coil. The first Pearson coil is arranged to induce a current of the first pulse signal and / or the second pulse signal. The second Pearson coil is arranged to induce a voltage to be applied to the resistor 7 by the first pulse signal and / or the second pulse signal. This allows monitoring of the voltage and output current output by the first pulse signal and / or the second pulse signal.

[0063] In one specific embodiment, a first pulse signal and a second pulse signal having predetermined parameters are generated. The two Pearson coils can induce corresponding currents and voltages. When the induction results of the two Pearson coils match the parameters of the first pulse signal and the second pulse signal, the Synergy pulse generator is in a normal operating state. When it is determined that the induction results of the two Pearson coils deviate from the parameters of the first pulse signal and the second pulse signal, it is determined that the Synergy pulse generator is in an inoperative state, so that an operator can immediately detect the malfunction and take corresponding measures.

[0064] For example, when the synergy pulse generating circuit of this embodiment is applied to the medical field, i.e., when it is applied to a pulse treatment device, the monitoring results from the monitor module can instantly determine whether the first pulse and / or second pulse output are normal, and coordination between the output at the load 3 and the set output parameters is maintained.

[0065] Based on the same inventive idea, an embodiment of the present invention provides a synergy pulse generator, as shown in Figure 4. The synergy pulse generator includes the synergy pulse generating circuit and a control module according to the above embodiment. The control module is electrically connected to the first pulse generating module 1 and the second pulse generating module 2, respectively, and is configured to generate a first control signal and a second control signal based on input information. The first control signal is transmitted to the first pulse generating module 1, and the second control signal is transmitted to the second pulse generating module 2.

[0066] The synergy pulse generating device according to this embodiment includes the beneficial effects of the synergy pulse generating circuit of the above-described embodiment, and therefore a description thereof will be omitted.

[0067] Specifically, the synergistic pulse generator of this embodiment can be used in an electrical ablation device that provides a synergistic output of a microsecond pulse and a nanosecond pulse, and can also be referred to as a micro-nano knife system. For example, the first pulse is a microsecond pulse and the second pulse is a nanosecond pulse. The micro-nano knife system can generate a combination of a nanosecond pulse and a microsecond pulse, and by applying the combination of a nanosecond pulse and a microsecond pulse to tumor tissue, the ablation effect of the tumor tissue can be effectively improved.

[0068] Based on the same inventive idea, an embodiment of the present invention also provides a synergistic pulse generating method, as shown in Figure 5. The synergistic pulse generating method includes:

[0069] In S1, an nth (n is an integer of 1 or more) stage first pulse generating unit 11 included in a first pulse generating module 1 receives and stores power supplied at a first voltage from a first power supply U1. An mth (m is an integer of 1 or more) stage second pulse generating unit 21 included in a second pulse generating module 2 receives and stores power supplied at a second voltage higher than the first voltage from a second power supply U2.

[0070] In addition, the charging process of the first pulse generating module 1 and the charging process of the second pulse generating module 2 may be performed simultaneously, or only the first pulse generating module 1 or the second pulse generating module 2 may be charged, or the charging process of the first pulse generating module 1 and the charging process of the second pulse generating module 2 may not be performed simultaneously.

[0071] Specifically, the n-stage first pulse generating unit 11 included in the first pulse generating module 1 receiving and storing the amount of power supplied at a first voltage from the first power supply U1 includes each first switch unit 112 turning off when it receives a third control signal, and connecting the first memory unit 111 of each stage in parallel to the first power supply U1 to receive and store the power supplied from the first power supply U1.

[0072] Taking the synergy pulse generating circuit shown in Figure 3 as an example, the charging process of the first pulse generating module 1 is as follows: 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 receives a third control signal, the solid-state switch element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 and solid-state switch element S 1-4 are both in the off state, and diode D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 has a one-way on function. This allows the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 are in a parallel relationship and are electrically connected to the first end and the second end of the first power supply U1, i.e., are both electrically connected to the positive and negative terminals of the first power supply U1. 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 The first pulse generating module 1 is charging until the potential difference between both ends of the first pulse generating module 1 and the second pulse generating module 1 reaches the first voltage.

[0073] Specifically, the mth stage second pulse generating unit 21 included in the second pulse generating module 2 receives and stores power supplied at a second voltage from the second power supply U2, and each second switch unit 212 turns off when it receives a fourth control signal, and the second memory unit 211 of each stage is connected in parallel to the second power supply U2 to receive and store the power supplied from the second power supply U2.

[0074] Taking the synergy pulse generating circuit shown in Figure 3 as an example, the charging process of the second pulse generating module 2 is as follows: 2-1 , solid-state switching element S 2-2 and solid-state switch element S 2-3 receives a fourth control signal, the solid-state switch element S 2-1 , solid-state switching element S 2-2 and solid-state switch element S 2-3 are both in the off state, and diode D 3-1 , diode D 3-2 , diode D 3-3 , diode D 3-4 , diode D 4-1 , diode D 4-2 and diode D 4-3 has a one-way on function. This allows the capacitor C 2-1 , capacitor C 2-2 and capacitor C 2-3 are in a parallel relationship and electrically connected to the first end and the second end of the second power supply 112, i.e., both are electrically connected to the positive and negative terminals of the second power supply U2. 2-1 , capacitor C 2-2 and capacitor C 2-3 The second pulse-generating module 2 is charging until the potential difference between both ends of the

[0075] In one specific embodiment, the first control signal and the second control signal are both high, while the third control signal and the fourth control signal are both low. That is, unless the first pulse-generating module 1 receives the first control signal, the first power supply U1 maintains a state in which the first capacitance of each stage is charged, or a state in which the voltage difference across the first capacitance of each stage is a first voltage. Similarly, unless the second pulse-generating module 2 receives the second control signal, the second power supply 122 maintains a state in which the second capacitance of each stage is charged, or a state in which the voltage difference across the second capacitance of each stage is a second voltage.

[0076] In S2, x (x is an integer greater than or equal to 1 and less than or equal to n) first pulse generating units 11 receive a first control signal, discharge under the control of the first control signal, and form a first pulse to be applied to load 3.

[0077] 5, the first pulse generating unit 11 has a first memory unit 111, a first switch unit 112, and a first off unit 113, and the first off unit 113 allows only a current from the first power supply U1 to the first pulse generating unit 11, or only a current from the first pulse generating unit 11 of the current stage to the first pulse generating unit 11 of the next stage. At this time, in step S2, the x first switch units 112 receive a first control signal and turn on under control of the first control signal, thereby connecting the x first memory units 111 of the same stage as the first switch unit 112 that received the first control signal in series and discharging them to form a first pulse.

[0078] 3, the first off unit 113 includes a first off unit and a second off unit. The first storage unit 111 has a first capacitance, the first switch unit 112 has a first solid-state switch element, the first off element has a first diode, and the second off element has a second diode. In this synergy pulse generating circuit, the first pulse generating module 1 includes four first pulse generating units 11, where n is equal to 4.

[0079] As shown in FIG. 3, the first switch units 112 in the first to fourth stages, i.e., the first solid-state switch elements in the first to fourth stages, are respectively solid-state switch elements S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 The first switch memories of the first to fourth stages, that is, the first capacitances of the first to fourth stages, are capacitors C 1-1 , capacitor C 1-2 , capacitor C 1-3 , capacitor C 1-4The first off elements of the first to fourth stages, that is, the first diodes of the first to fourth stages, are diodes D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 The second off elements in the first to fourth stages, that is, the second diodes in the first to fourth stages, are diodes D 2-1 , diode D 2-2 , diode D 2-3 , and diode D 2-4 is.

[0080] As shown in Figure 3, the solid-state switch element S 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 , and a solid-state switching element S 1-4 When any of the solid-state switch elements S receives a first switching signal, 1-1 , solid-state switching element S 1-2 , solid-state switching element S 1-3 and solid-state switch element S 1-4 are both on, and diode D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 has a one-way on function. This allows the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 are in a series relationship, and the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 discharge simultaneously. Since the discharge voltages are both the first voltage, the voltage of the formed pulse is four times the first voltage.

[0081] In S3, y (y is an integer between 1 and m) second pulse generating units 21 receive the second control signal, discharge under the control of the second control signal, and form a second pulse to be applied to the load 3. The width of the second pulse is smaller than the width of the first pulse. The time at which the second pulse generating units 21 receive the second control signal is different from the time at which the first pulse generating units 11 receive the first control signal.

[0082] 5, the second pulse generating unit 21 includes a second memory unit 211, a second switch unit 212, and a second off unit 213. The second off unit 213 allows only a current from the second power supply U2 to the second pulse generating unit 21, or only a current from the second pulse generating unit 21 of the current stage to the second pulse generating unit 21 of the next stage. At this time, in step S3, the y second switch units 212 receive the second control signal and are turned on under control of the second control signal, thereby connecting the y second memory units 211 of the same stage as the second switch unit 212 that received the second control signal in series and discharging them to form a second pulse.

[0083] 3, the second off unit 213 has a third off element and a fourth off element. The second storage unit 211 has a second capacitor, the second switch unit 212 has a second solid-state switch element, the third off element has a third diode, and the fourth off element has a fourth diode. In the synergy pulse generating circuit, the second pulse generating module 2 includes four stages of second pulse generating units 21, where m is equal to 3.

[0084] As shown in FIG. 3, the second switch sections 212 in the first to fourth stages, i.e., the second transistors in the first to third stages, are respectively solid-state switch elements S 2-1 , solid-state switching element S 2-2 and solid-state switching element S 2-3 The second storage units 211 in the first to third stages, that is, the second capacitances in the first to third stages, are respectively capacitors C 2-1 , capacitor C 2-2and capacitor C 2-3 The third off elements in the first to third stages, that is, the third diodes in the first to third stages, are respectively diodes D 3-1 , diode D 3-2 and diode D 3-3 The fourth off elements in the first to third stages, that is, the fourth diodes in the first to third stages, are diodes D 4-1 , diode D 4-2 and diode D 4-3 is.

[0085] As shown in Figure 3, the solid-state switch element S 2-1 , solid-state switching element S 2-2 and solid-state switch element S 2-3 When each of the solid-state switch elements S receives a second control signal, 2-1 , solid-state switching element S 2-2 and solid-state switch element S 2-3 are both in the on state. 2-1 , capacitor C 2-2 and capacitor C 2-3 are in series, and the capacitor C 2-1 , capacitor C 2-2 and capacitor C 2-3 are discharged simultaneously. Since the discharge voltages are both the second voltage, the voltage of the second pulse formed is three times the second voltage.

[0086] In S4, the first pulse and / or the second pulse is applied to the load 3.

[0087] The synergy pulse generation method in this embodiment can selectively form a first pulse and a second pulse with different widths, and by selecting the voltages of the first pulse and the second pulse, the purpose of applying a composite pulse to the load 3 is achieved. For example, if the load 3 is a tumor cell, the role of the composite pulse is advantageous in improving the ablation effect on the tumor cell.

[0088] The synergistic pulse generation method according to this embodiment may include only one of steps S1 and S2, or may include both steps simultaneously. The order of steps S1 and S2 may be adjusted according to actual needs, and different pulse combinations may be output according to actual needs. In a specific embodiment, the pulse combination includes a plurality of first pulse groups, each of which includes a number of first pulses and a time t1 between adjacent first pulses, each of which includes a number of first pulses and a time t2 between adjacent first pulses, i.e., only step S1 of the two steps S1 and S2 is included. In another embodiment, the pulse group includes a plurality of second pulse groups, each of which includes a number of second pulses and a time t3 between adjacent second pulses, each of which includes b number of second pulses and a time t4 between adjacent second pulses, i.e., only step S2 of the two steps S1 and S2 is included. In another specific embodiment, the pulse group may include a plurality of first pulses and a plurality of second pulses, and the first pulses and the second pulses may be applied alternately to the load 3. The second pulse may be reapplied to the load 3 after all of the first pulses have been applied to the load 3, or the second pulse may be reapplied to the load 3 after all of the second pulses have been applied to the load 3. These first pulses may form a plurality of first pulse groups, and these second pulses may form a plurality of second pulse groups. The first pulse groups and the second pulse groups are applied alternately to the load 3, i.e., both step S1 and step S2 are included.

[0089] The application of the embodiments of the present invention at least provides an advantage of realizing a synergistic pulse generating circuit, a generating device, and a generating method thereof according to the embodiments of the present invention. It is possible to selectively generate a first pulse and / or a second pulse with different widths, and to select the voltages of the first pulse and the second pulse. This achieves the purpose of applying a composite pulse to a load. For example, if the load is tumor cells, the role of the composite pulse is advantageous in improving the ablation effect on the tumor cells.

[0090] The terms "first" and "second" are merely descriptive and are not intended to indicate or suggest relative importance or the number of technical features that are presented. Therefore, a feature qualified by "first" or "second" may explicitly or implicitly include one or more features. In the description of this invention, "plurality" means two or more unless otherwise specified.

[0091] In the description of the present invention, the terms "mounted," "connected," and "coupled" should be understood in a broad sense unless otherwise clearly specified or limited, and may mean, for example, a fixed connection, a detachable connection, an integral connection, a direct connection, an indirect connection via an intermediate medium, or internal communication between two elements. The specific meanings of the above terms in the present invention will be specifically understood by those skilled in the art.

[0092] In the description herein, the particular features, structures, materials, or characteristics may be combined as appropriate in any one or more embodiments or examples.

[0093] It should be pointed out that the above are only some examples of the present invention, and those skilled in the art may make some improvements and modifications without departing from the principles of the present invention. [Explanation of symbols]

[0094] 1...first pulse generating module, 11...first pulse generating section, 111...first memory section, 112...first switch section, 113...first off section, 2...second pulse generating module, 21...second pulse generating section, 211...second memory section, 212...second switch section, 213...second off section, 3...load, U1...first power supply, U2...second power supply

Claims

1. a first power source; a first pulse generating module electrically connected to the first power supply, the first pulse generating module including n (n is an integer of 2 or more) stages of first pulse generating units configured to receive and store power supplied at a first voltage from the first power supply, and to discharge the stored power when a first control signal is received to discharge x (x is an integer of 1 or more and n or less) first pulse generating units that receive a first control signal to form first pulses to be applied to a load; a second power source; a second pulse generating module electrically connected to the second power supply, the second pulse generating module including m (m is an integer of 2 or more) stages of second pulse generating units configured to receive and store power supplied at a second voltage from the second power supply, and to discharge the stored power when a second control signal is received to discharge y (y is an integer of 1 or more and m or less) second pulse generating units that receive a second control signal to form second pulses to be applied to a load; The output terminals of the first pulse generating module and the second pulse generating module are arranged to be connected to the same load; the second voltage is greater than the first voltage, and the width of the second pulse is less than the width of the first pulse; the first pulse generating unit includes a first storage unit, a first switch unit, and a first off unit; the first switch unit receives the first control signal, and is turned on under control of the first control signal, thereby discharging the first storage units connected in series at the same stage as the first switch unit that receives the first control signal, in order to form the first pulse; the first off section is configured such that only a charging current flows from the first power supply to the first pulse generating section, or such that a charging current flows from the first pulse generating section of a current stage to the first pulse generating section of a next stage, and such that only a discharging current flows from the first pulse generating section of a current stage to the first pulse generating section of a next stage, the second pulse generating unit includes a second storage unit, a second switch unit, and a second off unit; the second switch unit receives the second control signal, and is turned on under control of the second control signal, thereby discharging the second storage units connected in series at the same stage as the second switch unit that receives the second control signal, in order to form the second pulse; the second off section is configured such that only a charging current flows from the second power supply to the second pulse generating section, or such that a charging current flows from the second pulse generating section of a current stage to the second pulse generating section of a next stage, and such that only a discharging current flows from the second pulse generating section of a current stage to the second pulse generating section of a next stage, the first off unit includes a first off element and a second off element, a first off element in a first stage electrically connected to a first end of the first power supply and a first end of a first storage unit in a first stage; The first off element in the i-th stage (i is an integer of 2 or more) is electrically connected to the first end of the first memory unit in the i-1-th stage, the first end of the first memory unit in the i-1-th stage, and the first off element in the i-1-th stage, the second off element of each stage is electrically connected to the second end of the first storage unit of the stage, the second end of the first switch of the stage, and the second off element of the next stage, respectively; the second off unit includes a third off element and a fourth off element, the third off element of the first stage is electrically connected to a first end of the second power supply and a first end of the second memory unit of the first stage, The third off element in the j-th stage (j is an integer of 2 or more) is electrically connected to the first end of the second memory unit in the j-1-th stage, the first end of the second memory unit in the j-1-th stage, and the third off element in the j-1-th stage, The fourth off element of each stage is electrically connected to the second end of the second storage unit of the stage, the second end of the second switch of the stage, and the fourth off element of the next stage. A synergy pulse generating circuit characterized by:

2. the first switch unit is configured to be turned off when a third control signal is received so that the first storage unit of each stage is connected in parallel to the first power supply and receives and stores power supplied from the first power supply; The second switch unit is configured to be turned off when a fourth control signal is received so that the second storage unit of each stage is connected in parallel to the second power supply and receives and stores power supplied from the second power supply.

2. The synergy pulse generating circuit according to claim 1.

3. both ends of the first memory unit in each stage are electrically connected to both ends of the first power supply, respectively, a control end of the first switch unit in each stage is configured to receive the first control signal, a first end and a second end of the first switch in each stage are electrically connected to a first end of the first memory unit in the current stage and a second end of the first memory unit in a next stage, respectively; Both ends of the second storage unit in each stage are electrically connected to both ends of the second power supply, respectively, and a control end of the second switch unit in each stage is configured to receive the second control signal, and a first end and a second end of the second switch in each stage are electrically connected to a first end of the second storage unit in the current stage and a second end of the second storage unit in the next stage, respectively.

2. The synergy pulse generating circuit according to claim 1.

4. the first storage unit has a first capacity, and the second storage unit has a second capacity; the first switch section includes a first solid-state switch element, and the second switch section includes a second solid-state switch element; The first off element includes a first diode, the second off element includes a second diode, the third off element includes a third diode, and the fourth off element includes a fourth diode.

2. The synergy pulse generating circuit according to claim 1.

5. Each of the first off elements in the second to n-th stages has one of the first diodes, each of the second off elements in each stage has one of the second diodes, and a reverse breakdown voltage of the first diode and a reverse breakdown voltage of the second diode are greater than the first voltage; Each of the third off elements in the second to m-th stages has one of the third diodes, and each of the fourth off elements in each stage has one of the fourth diodes, and the reverse breakdown voltage of the third diode and the reverse breakdown voltage of the fourth diode are greater than the second voltage.

5. The synergy pulse generating circuit according to claim 4.

6. the first off-elements of the first stage include s first diodes, and s (s is an integer of 1 or more) times the reverse breakdown voltage of the first diode is greater than (n-1) times the first voltage; The third off-element of the first stage includes t (t is an integer equal to or greater than 1) third diodes, and s times the reverse breakdown voltage of the third diode is greater than (m-1) times the second voltage.

6. The synergy pulse generating circuit according to claim 5.

7. The pulse generating circuit further comprises: a first earth leakage module electrically connected to the first pulse generating module and to a ground, and configured to conduct the first pulse generating module and to a ground under control of a first earth leakage signal so as to discharge residual power in the first pulse generating module; a second earth leakage module electrically connected to the second pulse generating module and to a ground, and configured to conduct the second pulse generating module and the ground under control of a second earth leakage signal so as to discharge residual power in the second pulse generating module.

2. The synergy pulse generating circuit according to claim 1.

8. the first pulse is a millisecond pulse or a microsecond pulse; The second pulse is a nanosecond pulse.

2. The synergy pulse generating circuit according to claim 1.

9. Further comprising a trigger portion and at least a pair of electrodes electrically connected to the trigger portion, the trigger unit is electrically connected to the first pulse generating module and the second pulse generating module, respectively, and the electrode is for connection to a load; The trigger unit is configured to be conductive when triggered by a trigger command to transmit a first pulse signal and / or a second pulse signal to the electrode.

2. The synergy pulse generating circuit according to claim 1.

10. The power supply further includes a monitor module for monitoring a voltage output by the first pulse signal and / or the second pulse signal and for monitoring a current output by the first pulse signal and / or the second pulse signal.

2. The synergy pulse generating circuit according to claim 1.

11. A synergy pulse generating circuit according to any one of claims 1 to 10; a control module electrically connected to the first pulse generating module and the second pulse generating module, respectively, configured to generate the first control signal and the second control signal based on input information, and to transmit the first control signal to the first pulse generating module and the second control signal to the second pulse generating module. A synergy pulse generator characterized by:

12. A synergy pulse generating method used in the synergy pulse generating circuit according to any one of claims 1 to 10, comprising: an nth (n is an integer of 2 or more) stage first pulse generating unit included in a first pulse generating module receives and stores power supplied from a first power supply at a first voltage, and an mth (m is an integer of 2 or more) stage second pulse generating unit included in a second pulse generating module receives and stores power supplied from a second power supply at a second voltage higher than the first voltage; x (x is an integer of 1 to n) first pulse generating units receive a first control signal and discharge under control of the first control signal to form a first pulse; y second pulse generating units (y is an integer of 1 to m) receive second control signals and discharge under the control of the second control signals to form second pulses; applying the first pulse and / or the second pulse to a load; The width of the second pulse is smaller than the width of the first pulse. A synergy pulse generating method.

13. The time when the second pulse generating unit receives the second control signal is different from the time when the first pulse generating unit receives the first control signal. The synergy pulse generating method according to claim 12.

14. the first pulse generating unit includes a first storage unit, a first switch unit, and a first off unit that allows a current to flow only from the first power supply to the first pulse generating unit or a current to flow only from the first pulse generating unit of a current stage to the first pulse generating unit of a next stage; receiving a first control signal from the x number of first pulse generating units and discharging under control of the first control signal to form a first pulse includes receiving the first control signal from the x number of first switch units and turning on under control of the first control signal, thereby connecting in series the x number of first storage units in the same stage as the first switch units that have received the first control signal and discharging them so as to form the first pulse; the second pulse generating unit includes a second storage unit, a second switch unit, and a second off unit that allows a current to flow only from the second power supply to the second pulse generating unit or a current to flow only from the second pulse generating unit of a current stage to the second pulse generating unit of a next stage, The y number of second pulse generating units receiving the second control signal and discharging under control of the second control signal to form the second pulse includes the y number of second switch units receiving the second control signal and turning on under control of the second control signal, thereby connecting in series the y number of second storage units in the same stage as the second switch units that received the second control signal and discharging them so as to form the second pulse. The synergy pulse generating method according to claim 12.

15. The n-stage first pulse generating unit included in the first pulse generating module receives and stores power supplied at a first voltage from a first power supply, and the first storage unit of each stage is turned off when it receives a third control signal, so that the first storage unit of each stage is connected in parallel to the first power supply and receives and stores power supplied from the first power supply; The m-stage second pulse generating units included in the second pulse generating module receive and store power supplied at a second voltage from a second power supply, and the second storage units of each stage are turned off when they receive a fourth control signal, so that the second storage units of each stage are connected in parallel to the second power supply and receive and store power supplied from the second power supply. The synergistic pulse generating method according to claim 14.

16. the first pulse is a millisecond pulse or a microsecond pulse; The second pulse is a nanosecond pulse. The synergy pulse generating method according to claim 12.

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