Drug Mixture Kit

Abstract

To provide a novel drug mixing and injecting kit excellent in safety.SOLUTION: A drug mixing and injecting kit 10 includes: a first assembly 12 in which a first cartridge 16 housing first drug is inserted in a cylindrical first barrel 18; a second assembly 14 in which a second cartridge 86 housing a second drug is inserted in a cylindrical second barrel 88; and a double-hook needle 54 communicating with both the first cartridge 16 and the second cartridge 86. The double-hook needle 54 has a configuration in which a first puncture member 56 punctured in a first elasticity lid body 26 and a second puncture member 58 punctured in a second elasticity lid body 96 are separably connected and is provided with a first anti-loosening mechanism 116 which prevents detachment of the first puncture member 56 from the first barrel 18 in the puncture state into the first elasticity lid body 26 of the first puncture needle 60, and the second puncture member 58 punctured in the second elasticity lid body 96 is separable from the first puncture member 56 and the first barrel 18 together with the second barrel 88.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a drug co-injection kit that mixes drugs contained in two cartridges before administration. [Background technology]

[0002] Conventionally, for example, in dental treatment, etc., drug co-injection kits have been provided that mix a drug and a drug solution before administration. For example, a drug co-injection kit, such as the syringe device disclosed in International Publication No. 2017 / 057659 (Patent Document 1), includes two syringe-shaped cartridges containing a drug and a drug solution, and a double-ended needle that penetrates the elastic valve body of each cartridge to connect the interiors of the cartridges to each other. Then, with the interiors of the two cartridges connected to each other by the double-ended needle, the pistons of each cartridge are alternately pressed to mix the drug and the solution, thereby adjusting the administered drug solution. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] International Publication No. 2017 / 057659 Summary of the Invention [Problem to be solved by the invention]

[0004] After the preparation of the drug solution by mixing drugs is completed, the drug injection kit removes one of the cartridges filled with the drug solution from the double-ended needle and attaches a hollow administration needle to the removed cartridge, allowing the drug solution in the cartridge to be injected into the patient's body. This hollow administration needle has needle tips on both sides so that it can puncture the patient's body while also penetrating the elastic valve of the cartridge. By piercing the elastic valve with one needle tip, preparation for administration of the drug solution is completed.

[0005] However, hollow injection needles, which have a special structure with needle tips on both sides, pose a high risk of medical personnel touching the needle tip during operation, and require careful handling.

[0006] Furthermore, some measures are also required for double-ended needles, since the tip of one of the needles is exposed when one cartridge is removed.Furthermore, for example, when one cartridge is removed from the double-ended needle, the double-ended needle may also come off from the other cartridge, and the tip of the double-ended needle may be exposed in an unintended manner.

[0007] An object of the present invention is to provide a novel drug co-injection kit that is safer. [Means for solving the problem]

[0008] The following describes preferred embodiments for understanding the present invention, but the embodiments described below are merely examples and may be appropriately combined with one another. Multiple components described in each embodiment may be recognized and employed independently to the greatest extent possible, and may also be appropriately combined with any of the components described in other embodiments. Accordingly, the present invention is not limited to the embodiments described below, and various other embodiments may be realized.

[0009] The first aspect is a drug mixer including a first assembly in which a first cartridge, which is a piston-type syringe containing a first drug and whose tip opening is sealed with a first elastic lid, is inserted into a first cylindrical barrel; a second assembly in which a second cartridge, which is a piston-type syringe containing a second drug and whose tip opening is sealed with a second elastic lid, is inserted into a second cylindrical barrel; and a double-ended needle that is pierced through the first elastic lid and the second elastic lid, respectively, to communicate the first cartridge with the second cartridge. The injection kit includes a double-ended needle having a connecting structure in which a first puncture member having a first puncture needle to be punctured into the first elastic cover and a second puncture member having a second puncture needle to be punctured into the second elastic cover are separably connected, and a first retention mechanism is provided that prevents the first puncture member from coming off the first barrel by engaging the first puncture member with the first barrel, thereby maintaining the first puncture needle in a state of puncturing the first elastic cover, and the connecting structure is The first puncture member and the second puncture member have a screw structure, and are screwed together by mutual rotation of the first puncture member and the second puncture member. The release of the connection allows the second puncturing member to be separated from the first puncturing member, and the second assembly in which the second puncturing needle of the second puncturing member has punctured the second elastic cover can be removed from the first assembly in which the first puncturing member has been locked to the first barrel by the first removal prevention mechanism; the second puncturing member has a second cylindrical portion that is engaged with and fitted onto the tip portion of the second barrel at the puncturing position of the second puncturing needle in the second puncturing cover; The first barrel extends further forward than the first cartridge and includes the double-ended needle. and the second cylindrical portion The needle holder has a cylindrical needle housing portion that houses the needle. The needle housing The tip of the second barrel Inside Move towards the department and bring in the gifts. It has a cylindrical part that can be The second puncture needle is adapted to puncture the second elastic cover inside the needle accommodating section.

[0010] In the drug co-infusion kit constructed according to this aspect, the second puncture member of the double-ended needle is separated from the first puncture member and the first barrel together with the second barrel while puncturing the second elastic cap, so that the hollow administration needle used to administer the mixed drug solution to a patient does not require a needle tip to penetrate the second elastic cap, thereby improving safety when handling the hollow administration needle compared to conventional hollow administration needles with needle tips on both sides.

[0011] Because the first puncture member and the second puncture member are separable, the first barrel (first cartridge) and the second barrel (second cartridge) are separated from each other when the first puncture needle is inserted into the first elastic cover and the second puncture needle is inserted into the second elastic cover. Therefore, even when removing the second cartridge, the first puncture needle and the second puncture needle are not accidentally exposed, and contact with the needle tip of the double-ended needle can be prevented. Furthermore, with the drug co-injection kit constructed according to this aspect, the double-ended needle is housed in the needle housing of the first barrel, making it less likely that unintended contact will occur with the double-ended needle. For example, even when the second barrel and the second cartridge are separate from the first barrel and the first cartridge, it is less likely that the tip of the second puncture needle of the double-ended needle will come into contact, improving safety. Furthermore, the double-ended needle can be handled integrally with the first assembly, making it easier to handle.

[0012] No. 2 The embodiment is 1 of In the drug co-injection kit described in the embodiment, the communicating portion of the second puncture member that is connected to the first puncture member and connects the first puncture needle and the second puncture needle is a luer portion having a luer taper, and the luer portion is a luer portion for attaching a hollow needle.

[0013] In the drug co-injection kit constructed according to this aspect, the second puncture member separated from the first cartridge while punctured by the second elastic cover has a luer part, which makes it possible to use, for example, a general hollow syringe needle equipped with a connector having a luer taper that is attached to the tip of a syringe as the hollow administration needle. Note that the luer part is preferably a luer specified in ISO 80369.

[0014] Furthermore, by providing the first puncture member with a structure that can be connected to the luer part, it is possible to easily achieve a separable connection between the first puncture member and the second puncture member.

[0017] No. 3The first aspect is or second In the drug co-injection kit described in the above aspect, the first puncture member has a first cylindrical portion that surrounds the outer periphery of the first puncture needle, and the first removal prevention mechanism is constituted by a first axial locking portion that is locked axially between the first cylindrical portion and the first barrel when the first puncture needle is in a state where it has punctured the first elastic cover body.

[0018] According to the medicine co-injection kit constructed according to this aspect, the first axial locking portion can prevent the first puncture member from coming off the first barrel with a simple structure.

[0019] No. 4 The first to second aspects are 3 In the drug co-injection kit described in any one of the above aspects, the first puncture member and the second puncture member are screwed together in the double-ended needle, a first rotation limiting mechanism is provided that limits the relative rotation between the first barrel and the first puncture member when the first puncture needle is in a state of puncturing the first elastic cover, and a second rotation limiting mechanism is provided that limits the relative rotation between the second barrel and the second puncture member when the second puncture needle is in a state of puncturing the second elastic cover, and the relative rotation between the second barrel and the first barrel is exerted on the first puncture member and the second puncture member to release the screw engagement, and the second puncture member is separated from the first puncture member and the first barrel together with the second barrel.

[0020] With the drug co-infusion kit configured according to this aspect, the first puncture member and the second puncture member can be easily unscrewed by twisting the first barrel and the second barrel relative to each other. Because the first puncture member and the second puncture member can be separated by unscrewing them, there is no need to apply a large tensile force, and unintended separation, such as the first puncture member coming off the first barrel together with the second puncture member, can be prevented.

[0021] No. 5 The embodiment is 4In the drug co-injection kit described in the above aspect, the first puncture member has a first cylindrical portion that surrounds the outer periphery of the first puncture needle, and the first rotation limiting mechanism is constituted by a first circumferential locking portion that is locked circumferentially between the first cylindrical portion and the first barrel when the first puncture needle is in a state where it has punctured the first elastic cover body.

[0022] According to the drug injection kit constructed in accordance with this embodiment, the first rotation limiting mechanism is constructed using the first cylindrical portion that surrounds the outer periphery of the first puncture needle, thereby providing a large resistance (torque) against rotation.

[0023] No. 6 The embodiment is 4 or 5 In the drug co-injection kit described in the above aspect, the second puncture member has a second tubular portion that is inserted onto the tip of the second barrel when the second puncture needle is in a state of puncturing the second elastic cover, and the second rotation limiting mechanism is constituted by a second circumferential locking portion that is circumferentially locked between the second tubular portion and the second barrel when the second puncture needle is in a state of puncturing the second elastic cover.

[0024] According to the drug injection kit constructed in accordance with this aspect, the second rotation limiting mechanism is constructed using the second cylindrical portion that surrounds the outer periphery of the second puncture needle, thereby providing a large resistance (torque) against rotation.

[0025] No. 7 The first to second aspects are 6 In the drug co-injection kit described in any one of the above aspects, the second puncture member has a second tubular portion that is inserted onto the tip of the second barrel when the second puncture needle is in a state of puncturing the second elastic cover, and a second axial locking portion that is axially locked between the second tubular portion and the second barrel constitutes a second removal mechanism that prevents the second puncture member from coming off the second barrel.

[0026] According to the drug co-injection kit constructed in accordance with this aspect, the second puncture member and the second barrel are prevented from separating by the second retention mechanism, and therefore the second puncture member can be separated from the first barrel together with the second barrel and the second cartridge.

[0027] No. 8 The first to second aspects are 7 The drug co-injection kit according to any one of the above aspects is provided with a first positioning mechanism that positions the first barrel and the first cartridge relative to each other in the axial direction, and a second positioning mechanism that positions the second barrel and the second cartridge relative to each other in the axial direction.

[0028] With the drug co-injection kit constructed according to this aspect, separation of the first cartridge and the first barrel is prevented, and separation of the second cartridge and the second barrel is prevented, and separation of the first barrel and the second cartridge is reliably achieved. Furthermore, by positioning the second cartridge and the second barrel, the second puncture needle of the second puncture member that separates integrally with the second barrel is maintained in a state where it is punctured by the second elastic cover that seals the opening of the second cartridge.

[0029] No. 9 The first to second aspects are 8 In the drug co-injection kit described in any one of the above aspects, the first barrel is provided with a first flange-shaped portion that protrudes outward, and the second barrel is provided with a second flange-shaped portion that protrudes outward, and the outer surfaces of the first flange-shaped portion and the second flange-shaped portion are used as surfaces to be operated by fingers.

[0030] According to the drug co-injection kit constructed according to this aspect, the first barrel and the second barrel can be easily separated by holding the operating surfaces of the first flange and the second flange. In particular, when the first puncture member and the second puncture member are connected by screwing and the first puncture member and the second puncture member are separated by twisting the first barrel and the second barrel, as in the fifth to seventh aspects, the separation can be performed with a relatively small input by applying a torsional force to the large-diameter first flange and the second flange. [Effects of the Invention]

[0031] According to the present invention, it is possible to achieve superior safety in a drug co-injection kit. [Brief explanation of the drawings]

[0032] [Figure 1] FIG. 2 is a cross-sectional view showing a drug co-injection kit according to a first embodiment of the present invention; [Figure 2] II-II cross section of Figure 1 [Figure 3] FIG. 2 is a perspective view of a first barrel constituting the drug co-injection kit shown in FIG. [Figure 4] Cross-sectional view of the first barrel shown in Figure 1 [Figure 5] FIG. 2 is a perspective view of a first puncture member constituting the drug co-injection kit shown in FIG. 1; [Figure 6] FIG. 2 is a perspective view of a second puncture member constituting the drug co-injection kit shown in FIG. 1; [Figure 7] FIG. 2 is a perspective view of a second barrel constituting the drug co-injection kit shown in FIG. [Figure 8] 8 is a cross-sectional view showing a state in which the double-ended needle is inserted into the first elastic cover and the second elastic cover in the drug mixed injection kit shown in FIG. 1, and corresponds to the cross section VIII-VIII in FIG. 9. [Figure 9] IX-IX cross section of Figure 8 [Figure 10] FIG. 2 is an enlarged perspective cross-sectional view of a first rotation limiting mechanism in the drug co-injection kit of FIG. [Figure 11]FIG. 2 is an enlarged perspective cross-sectional view of a second rotation limiting mechanism in the drug co-injection kit of FIG. [Figure 12] FIG. 2 is a cross-sectional view of the drug mixed injection kit shown in FIG. 1, showing a state in which the administration syringe is separated from the first barrel side. [Figure 13] 13 is a diagram illustrating the connection of an administration hollow needle to the administration syringe shown in FIG. 12. DETAILED DESCRIPTION OF THE INVENTION

[0033] Hereinafter, an embodiment of the present invention will be described with reference to the drawings.

[0034] 1 and 2 show a drug co-injection kit 10 as a first embodiment of the present invention. The drug co-injection kit 10 has a first assembly 12 and a second assembly 14. In the following description, the first assembly 12 and the second assembly 14 are arranged facing each other, and the distal end side of the first assembly 12 and the distal end side of the second assembly 14 are in opposite directions. In other words, the first side, which is the left side in FIG. 1, is the proximal end side of the first assembly 12 and the distal end side of the second assembly 14, and the second side, which is the right side in FIG. 1, is the distal end side of the first assembly 12 and the proximal end side of the second assembly 14.

[0035] The first assembly 12 has a structure in which a first cartridge 16 is inserted into a first barrel 18. The first cartridge 16 is a piston-type syringe in which a first plunger 22 is inserted into a first cylinder 20. The first cylinder 20 has a substantially cylindrical shape and includes a first storage area 24 therein. The material of the first cylinder 20 is appropriately selected depending on factors such as corrosion resistance to the drug stored in the first storage area 24, and is formed from, for example, glass, synthetic resin, metal, etc.

[0036] The opening on the second side, which is the tip side of the first cylinder 20, is fluid-tightly sealed by a first elastic lid 26. The first elastic lid 26 is formed of an elastic material such as rubber or a resin elastomer, and is inserted into the small-diameter tip portion of the first cylinder 20. The second-side end of the first elastic lid 26 protrudes further toward the second side than the first cylinder 20 and is overlapped with the tip surface of the first cylinder 20. The first elastic lid 26 is prevented from slipping off from the first cylinder 20 to the second side by a first fixing member 28 that fits into the second-side end of the first cylinder 20. The first fixing member 28 is tubular and has a bottom on the second side. A first tip through-hole 30 that penetrates the bottom of the first fixing member 28 in the axial direction (left-right direction in FIG. 1 ) is provided in the bottom of the first fixing member 28, and the first elastic lid 26 is exposed to the second side through the first tip through-hole 30. In addition, the first elastic cover 26 may be fixed to the first cylinder 20 by means of adhesion, welding, or the like, which prevents the first elastic cover 26 from coming off the first cylinder 20 and makes it easier to seal the opening of the first cylinder 20 fluid-tightly with the first elastic cover 26.

[0037] The first plunger 22 is rod-shaped so as to be insertable into the first cylinder 20, with a first end having a larger diameter and a second end covered with a first rubber tip 32 that is in fluid-tight contact with the inner circumferential surface of the first cylinder 20. The first plunger 22 is desirably hollowed out to reduce the amount of material required; for example, the first side from the attachment portion of the first rubber tip 32 may extend in the axial direction with a cross-shaped cross section, or the outer circumferential surface may be hollowed out so as to have a number of recesses opening into it, but in this embodiment, hollowed out holes that open towards the base end are formed on the central axis.

[0038] As shown in FIGS. 3 and 4 , the first barrel 18 has an overall cylindrical shape. A first side portion of the first barrel 18 forms a first cartridge accommodating section 34 that accommodates the first cartridge 16. A first flange-shaped section 36 that protrudes outward is provided near the first end of the first cartridge accommodating section 34. The first flange-shaped section 36 has a plate-shaped section that protrudes outward from the first cartridge accommodating section 34 and extends from the outer circumferential end of the plate-shaped section in the direction of the first arrow in the drawings, and its outer circumferential surface forms a first operating surface 38 that is operated by fingers. As shown in FIG. 3 , the first flange-shaped section 36 is a non-cylindrical surface whose protruding dimension from the first cartridge accommodating section 34 to the outer periphery varies circumferentially, and the first operating surface 38 has a structure that includes six circumferentially curved concave surfaces that are continuously arranged in the circumferential direction.

[0039] A pair of first positioning pieces 40, 40 that incline inward toward the second side are provided at the second side end of the first cartridge accommodating section 34. The first cartridge 16 is inserted into the first cartridge accommodating section 34 of the first barrel 18 from the first side, and is inserted into the first cartridge accommodating section 34 until the first fixing member 28 climbs over the first positioning pieces 40, 40 and reaches the second side beyond the first positioning pieces 40, 40. Then, the first fixing member 28 and the first positioning pieces 40, 40 are engaged in the axial direction, thereby forming a first positioning mechanism that positions the first barrel 18 and the first cartridge 16 relative to each other in the axial direction, and prevents the first cartridge 16 from coming off the first barrel 18.

[0040] The second side portion of the first barrel 18 is a needle accommodating portion 42. The needle accommodating portion 42 is cylindrical and has a larger diameter than the first cartridge accommodating portion 34. The needle accommodating portion 42 extends further toward the second side (tip side) from an annular position determining portion 44 that protrudes toward the outer periphery near the second side end of the first cartridge accommodating portion 34. The second side end of the first cartridge accommodating portion 34 is disposed at the first side end of the needle accommodating portion 42. The first side end of the needle accommodating portion 42 is provided with first windows 46, 46 that penetrate radially. The first window 46 is a rectangular hole, and a first locking piece 48 is provided that protrudes from the second side edge of the first window 46 toward the first side. The first locking piece 48 protrudes into the first window 46 and gradually slopes radially inward from the second side toward the first side.

[0041] As shown in Figure 4, the needle accommodating section 42 is provided with positioning ribs 50, 50 on a first side portion where a first puncturing member 56, described later, is accommodated. The positioning ribs 50, 50 protrude from the inner peripheral surface of the needle accommodating section 42 and extend circumferentially. The two positioning ribs 50, 50 are arranged spaced apart from each other in the axial direction, and the axial distance between the positioning ribs 50 is approximately the same as or slightly greater than the axial length of a locking protrusion 68 of the first puncturing member 56, described later. The positioning rib 50 extends circumferentially with a substantially semicircular cross section so that the locking protrusion 68, described later, can ride over it.

[0042] A rotation-limiting rib 52 is provided on the first side portion of needle accommodating section 42. Rotation-limiting rib 52 protrudes from the inner peripheral surface of needle accommodating section 42 and extends linearly in the axial direction. Multiple rotation-limiting ribs 52 are provided at predetermined distances from each other in the circumferential direction. Each rotation-limiting rib 52 extends in the axial direction with a substantially rectangular cross section whose both circumferential surfaces extend substantially perpendicular to the circumferential direction so that a locking protrusion 68 (described later) does not climb over it in the circumferential direction.

[0043] A double-ended needle 54 is housed in the needle housing 42. In this embodiment, the double-ended needle 54 is attached in advance to the first barrel 18 of the first assembly 12, and can be handled integrally with the first assembly 12. The double-ended needle 54 has a structure in which a first puncturing member 56 shown in FIG. 5 and a second puncturing member 58 shown in FIG. 6 are connected together.

[0044] As shown in FIGS. 1 and 2, the first puncture member 56 includes a first puncture needle 60. The first puncture needle 60 is a hollow needle with a needle tip on the first side and an axially extending lumen. The base end of the first puncture needle 60 includes a first flange-shaped portion 62 that expands toward the outside. The inner periphery of the first flange-shaped portion 62 includes a female luer 64 that protrudes toward the second side. The female luer 64 is generally cylindrical in shape, has a female luer taper where the inner periphery has a larger diameter toward the second side, and has a male thread on the outer periphery. The female luer 64 is preferably a luer defined in ISO 80369. The outer periphery of the first flange-shaped portion 62 includes a first tubular portion 66 that protrudes toward the first side. The first tubular portion 66 is generally cylindrical and is disposed so as to surround the first puncture needle 60. The first cylindrical portion 66 is thin-walled to allow for flexible deformation. As shown in Fig. 5, the first cylindrical portion 66 is provided with a plurality of locking protrusions 68 that protrude from the outer peripheral surface at the first end. The locking protrusions 68 are arranged at approximately equal intervals in the circumferential direction. At the first end, the locking protrusions 68 gradually become narrower toward the first side.

[0045] As shown in FIGS. 1 and 2, the second puncture member 58 includes a second puncture needle 70. The second puncture needle 70 is a hollow needle with a tip on the second side and a lumen penetrating in the axial direction. The base end of the second puncture needle 70 is provided with a second flange-shaped portion 72 that widens toward the outside. The inner peripheral portion of the second flange-shaped portion 72 is provided with a male luer 74 as a luer portion that protrudes toward the first side. The male luer 74 is generally cylindrical in shape and has a male luer taper where the outer peripheral surface has a larger diameter toward the second side. The male luer 74 is preferably a luer specified in ISO 80369. The lure of the second puncture needle 70 is connected to the lure of the male luer 74, penetrating the second puncture member 58 in the axial direction. A tubular luer lock portion 76 is disposed on the outer peripheral side of the male luer 74 so as to surround the outer periphery of the male luer 74. The luer lock portion 76 has a female thread provided on its inner circumferential surface, which can be threadedly engaged with the male thread provided on the female luer 64 of the first puncture member 56 .

[0046] The outer peripheral end of the second flange-shaped portion 72 is provided with a second cylindrical portion 78 that protrudes toward the second side. The second cylindrical portion 78 is provided with multiple inner peripheral protrusions 80 that protrude from its inner peripheral surface. The multiple inner peripheral protrusions 80 are arranged at approximately equal intervals in the circumferential direction. The protrusion dimension of the inner peripheral protrusions 80 at the second side end gradually decreases toward the second side. A pair of second window portions 82, 82 is provided in the peripheral wall of the second cylindrical portion 78 at positions facing each other in the radial direction. A second locking piece 84 protrudes toward the first side from the second side edge of the second window portion 82. The second locking piece 84 protrudes into the second window portion 82 and gradually inclines radially inward toward the first side.

[0047] The first puncture member 56 and the second puncture member 58 are connected to each other by mating the female luer 64 of the first puncture member 56 and the male luer 74 of the second puncture member 58. The first puncture member 56 and the second puncture member 58 are also connected by threading the male thread on the outer circumferential surface of the female luer 64 into the female thread of the luer lock portion 76, and will not separate even when tensile force is applied in the axial direction. The double-ended needle 54 is configured by connecting the first puncture member 56 and the second puncture member 58 in this manner. The double-ended needle 54 has a first puncture needle 60 protruding toward a first side and a second puncture needle 70 protruding toward a second side, and has needle tips on both axial sides. In the double-ended needle 54, the male luer 74 forms a communication portion that connects the first puncture needle 60 and the second puncture needle 70. In short, the inner lumens of the first puncture needle 60 and the second puncture needle 70 are connected through the inner lumens of the male luer 74, so that the inner lumens of the continuous first puncture needle 60, second puncture needle 70 and male luer 74 penetrate the double-ended needle 54 in the axial direction.

[0048] The first puncture member 56 and the second puncture member 58 can be separated from each other by relative rotation (torsional displacement) to release the threaded engagement between the female luer 64 and the luer lock portion 76. In short, the double-ended needle 54 is configured by connecting the first puncture member 56 and the second puncture member 58 in a separable manner.

[0049] In the double-ended needle 54 of this embodiment, both the first puncture member 56 and the second puncture member 58 are made entirely of synthetic resin, and the first puncture needle 60 can be formed integrally with the first puncture member 56, and the second puncture needle 70 can be formed integrally with the second puncture member 58. This makes manufacturing safer and easier than insert molding a metal puncture needle.

[0050] The double-ended needle 54 is housed in the needle housing 42 of the first barrel 18. Two positioning ribs 50, 50 protrude from the inner peripheral surface of the needle housing 42 at positions spaced apart in the axial direction, and the double-ended needle 54 is positioned in the axial direction within the needle housing 42 by inserting the locking projection 68 of the first puncturing member 56 between the positioning ribs 50, 50. The double-ended needle 54 housed in the needle housing 42 is disposed such that the needle tip of the first puncturing needle 60 is located further distal than the first cartridge 16. The double-ended needle 54 does not necessarily have to be housed entirely in the needle housing 42, but preferably, the entirety of the double-ended needle 54 is housed entirely in the needle housing 42, thereby preventing unintended contact with the double-ended needle 54 and direct twisting of the second puncturing member 58. In particular, when the second assembly 14 is independent of the first assembly 12 in the drug co-injection kit 10, the entire double-ended needle 54 is housed in the needle housing section 42, thereby preventing unintended contact with the needle tip of the second puncture needle 70 and improving safety.

[0051] The second assembly 14 has a structure in which a second cartridge 86 is inserted into a second barrel 88. The second cartridge 86 has a piston-type syringe structure in which a second plunger 94 is inserted into a second storage area 92 of a second cylinder 90, and the opening on the tip side (first side) of the second cylinder 90 is fluid-tightly sealed by a second elastic lid 96. The second cartridge 86 has substantially the same structure as the first cartridge 16. That is, the second cylinder 90, the second plunger 94, and the second elastic lid 96 have substantially the same structure as the first cylinder 20, the first plunger 22, and the first elastic lid 26, and therefore detailed description thereof will be omitted here. In addition, a second tip rubber 98 corresponding to the first tip rubber 32 is provided on the first side end of the second plunger 94. The second elastic cover 96 is fixed to the second cylinder 90 by a second fixing member 100 having a structure corresponding to that of the first fixing member 28, and the second fixing member 100 has a second tip through-hole 102 formed therein that penetrates the bottom.

[0052] 7, the second barrel 88 has a cylindrical shape as a whole and includes a second cartridge accommodating portion 104 into which the second cartridge 86 is inserted. A second flange portion 106 that protrudes outward is provided near the second end of the second cartridge accommodating portion 104. The second flange portion 106 has substantially the same structure as the first flange portion 36, and therefore its outer circumferential surface forms a second operating surface 108 whose shape corresponds to that of the first operating surface 38, although a description thereof will be omitted here.

[0053] An outer peripheral protrusion 110 protruding from the outer peripheral surface is provided at the first end of the second cartridge accommodating section 104. The outer peripheral protrusion 110 is rib-shaped and extends in the axial direction, and multiple outer peripheral protrusions 110 are arranged at approximately equal intervals in the circumferential direction. The width of the outer peripheral protrusion 110 gradually narrows toward the first side at the first end.

[0054] The second cartridge accommodating portion 104 has window-shaped openings 112, 112 formed on both radial sides. The window-shaped openings 112 are provided adjacent to the second side of the outer peripheral protrusion 110. A second positioning piece 114 protruding into the window-shaped opening 112 is provided at the edge of the second side of the window-shaped opening 112. The second positioning piece 114 is inclined radially inward toward the first side, which is the protruding tip side. Similar to the first positioning piece 40, the second positioning piece 114 is allowed to bend and deform, allowing the second fixing member 100 to pass from the second side to the first side. In addition, the engagement with the second fixing member 100 inserted toward the first side beyond the second positioning piece 114 prevents the second cartridge 86 from slipping out of the second barrel 88 to the second side, thereby forming a second positioning mechanism that positions the second barrel 88 and the second cartridge 86 relative to each other in the axial direction.

[0055] The drug co-injection kit 10 is configured including the first assembly 12 and the second assembly 14 configured as described above. In the drug co-injection kit 10 of this embodiment, the first assembly 12 and the second assembly 14 are independent of each other. This makes it possible to reduce the axial length of the drug co-injection kit 10 compared to when the first assembly 12 and the second assembly 14 are previously combined in series in the axial direction. That is, although FIGS. 1 and 2 show the first assembly 12 and the second assembly 14 arranged facing each other in the axial direction, for example, the package size can be reduced by packaging the independent first assembly 12 and the second assembly 14 in parallel.

[0056] In the drug co-injection kit 10, the first drug housed in the first cartridge 16 of the first assembly 12 and the second drug housed in the second cartridge 86 of the second assembly 14 are different drugs. At least one of the first drug and the second drug has fluidity such as liquid or gel. Specifically, for example, the second drug may be a solid drug, and the first drug may be a solvent that dissolves the second drug. However, both the first drug and the second drug may be liquid.

[0057] The drug co-injection kit 10 is used as follows. First, the first assembly 12 and the second assembly 14 are arranged with their distal ends facing each other, as shown in FIGS. 1 and 2 , and the second assembly 14 is inserted into the distal end opening of the first assembly 12. The distal end opening of the first assembly 12 is formed by the second tubular portion 78 of the second puncture member 58, and the distal end of the second assembly 14 (second barrel 88) is inserted into the second tubular portion 78. In the drug co-injection kit 10 of this embodiment, the double-ended needle 54 is pre-set in the needle housing portion 42 of the first barrel 18 of the first assembly 12, eliminating the need to attach the double-ended needle 54 to the first assembly 12. For example, a user can easily perform the operation by holding the first assembly 12 and the second assembly 14 with the double-ended needle 54 in their left and right hands.

[0058] By bringing the first assembly 12 and the second assembly 14 closer to each other, the second puncture needle 70 punctures the second elastic cover 96 of the second cartridge 86. The second puncture needle 70 may penetrate the second elastic cover 96, or may puncture the second elastic cover 96 partway through without penetrating it.

[0059] Due to the resistance to puncture of the second puncture needle 70 against the second elastic cover 96 or the abutment of the second barrel 88 against the second flange-shaped portion 72, a force is applied to the double-ended needle 54 pushing it towards the first side, causing the double-ended needle 54 to move towards the first side relative to the first barrel 18. The double-ended needle 54 is positioned relative to the needle accommodating section 42 of the first barrel 18 by the engagement between the locking projection 68 and the positioning ribs 50, 50, but the action of an external force causes the locking projection 68 to move over the positioning rib 50 and move towards the first side.

[0060] As the double-ended needle 54 moves toward the first side, the first puncture needle 60 punctures the first elastic cover 26 of the first cartridge 16. By further moving the first assembly 12 and the second assembly 14 closer to each other, the first puncture needle 60 penetrates the first elastic cover 26 and the second puncture needle 70 penetrates the second elastic cover 96, as shown in Figures 8 and 9. As a result, the first storage area 24 of the first cartridge 16 containing the first drug and the second storage area 92 of the second cartridge 86 containing the second drug are connected to each other through the inner cavities of the first and second puncture needles 60, 70 and the inner cavities of the male luer 74 connecting the inner cavities of the first and second puncture needles 60, 70.

[0061] When the first cartridge 16 and the second cartridge 86 are in close proximity with each other and the first storage area 24 and the second storage area 92 interconnected, the end face of the first tubular portion 66 of the first puncture member 56 abuts against the position determining portion 44, thereby limiting the amount of movement of the first puncture member 56 toward the first side relative to the first barrel 18.

[0062] The first puncturing member 56 is positioned on the first side with the locking protrusion 68 climbing over the first locking piece 48, and the amount of movement of the first puncturing member 56 toward the second side relative to the first barrel 18 is limited by the first axial locking portion 116 formed by the locking of the locking protrusion 68 and the first locking piece 48. As described above, in this embodiment, when the first puncturing needle 60 has punctured the first elastic cover 26, the first prevention mechanism that prevents the first puncturing member 56 from coming off the first barrel 18 toward the second side is configured to include the first axial locking portion 116 with a simple locking structure. Note that, for example, frictional resistance acting between the first puncturing needle 60 and the first elastic cover 26 also acts to make it difficult for the first puncturing member 56 to come off the first barrel 18.

[0063] As a result, the first puncture member 56 is positioned on both axial sides relative to the first barrel 18, and the double-ended needle 54 including the first puncture member 56 is positioned on both axial sides relative to the first barrel 18.

[0064] When the first cartridge 16 and the second cartridge 86 are in a close proximity state with the first puncture needle 60 puncturing the first elastic cover 26, as shown in FIG. 10 , the locking protrusion 68 is circumferentially locked to the rotation-limiting rib 52 formed on the inner circumferential surface of the first barrel 18. The relative rotation (torsional displacement) between the first puncturing member 56 and the first barrel 18 is limited by a first circumferential locking portion 118 formed by the locking of the locking protrusion 68 and the rotation-limiting rib 52. As described above, in this embodiment, the first rotation-limiting mechanism that limits the relative rotation between the first barrel 18 and the first puncturing member 56 is provided with a simple structure using the first circumferential locking portion 118. The locking protrusion 68 that constitutes the first rotation-limiting mechanism is provided on the first tubular portion 66 that constitutes the outer circumferential end of the first puncturing member 56, and a resistance force against the relative rotation between the first puncturing member 56 and the first barrel 18 is efficiently exerted with a large torque. Note that it is not necessary for all of the locking protrusions 68 to constitute the first rotation limiting mechanism, and in this embodiment, there are more locking protrusions 68 than rotation limiting ribs 52, which makes it difficult for the circumferential orientation of the first puncturing member 56 to be restricted when inserting it into the first barrel 18, and reduces the allowable amount of relative rotation between the first barrel 18 and the first puncturing member 56.

[0065] When the first cartridge 16 and the second cartridge 86 are in a close proximity state with the second puncture needle 70 puncturing the second elastic cover 96, as shown in FIG. 8 , the outer peripheral protrusion 110 of the second barrel 88 passes over the second locking piece 84 of the second puncture member 58 and is inserted toward the first side. The second axial locking portion 120, formed by the axial locking of the outer peripheral protrusion 110 and the second locking piece 84, limits the amount of movement of the second barrel 88 toward the second side relative to the second puncture member 58. In this manner, the second removal mechanism, which prevents the second barrel 88 from separating from the second puncture member 58 toward the second side, is configured by the second axial locking portion 120 with a simple locking structure. For example, frictional resistance acting between the second puncture needle 70 and the second elastic cover 96 also acts to make it difficult for the second barrel 88 to separate from the second puncture member 58.

[0066] When the first cartridge 16 and the second cartridge 86 are in an approaching state with the second puncture needle 70 puncturing the second elastic cover 96, the outer peripheral protrusion 110 of the second barrel 88 is inserted circumferentially between the inner peripheral protrusions 80 of the second puncture member 58, as shown in Fig. 11 . The outer peripheral protrusions 110 and the inner peripheral protrusions 80 are circumferentially engaged to form a second circumferential engaging portion 122, and a second rotation limiting mechanism that limits relative rotation (torsional displacement) about the central axis of the second barrel 88 and the second puncture member 58 is configured with a simple engaging structure by the second circumferential engaging portion 122. The inner peripheral protrusions 80 that constitute the second rotation limiting mechanism are provided on the second tubular portion 78 that constitutes the outer peripheral end of the second puncture member 58, and a resistance force against relative rotation between the second puncture member 58 and the second barrel 88 is efficiently exerted with a large torque. In this embodiment, since there are more outer peripheral protrusions 110 than inner peripheral protrusions 80, the circumferential orientation is less likely to be restricted when inserting the second barrel 88 into the second puncture member 58, and the allowable amount of relative rotation between the second barrel 88 and the second puncture member 58 is reduced.

[0067] Next, with the first storage area 24 and the second storage area 92 in communication with each other, a drug mixing operation is performed by alternately pushing the first plunger 22 of the first cartridge 16 and the second plunger 94 of the second cartridge 86. By alternately pushing the first plunger 22 and the second plunger 94 in this manner, the first drug stored in the first cartridge 16 and the second drug stored in the second cartridge 86 are moved back and forth between the first storage area 24 and the second storage area 92, allowing the first drug and the second drug to be mixed. It is desirable to repeat the mixing operation multiple times, thereby ensuring that the first drug and the second drug are mixed evenly.

[0068] When preparation of the medicinal liquid to be administered by mixing the first and second drugs is completed, the first plunger 22 is pushed in, and with the medicinal liquid to be administered contained in the second containing area 92, the second barrel 88 is rotated (torsional displacement) relative to the first barrel 18. By pinching the first flange 36 of the first barrel 18 and the second flange 106 of the second barrel 88 with the fingers and applying a force in the torsional direction, the first barrel 18 and the second barrel 88 can be rotated relative to each other with a smaller force.

[0069] Furthermore, the outer peripheral surface of the first flange portion 36 is the first operation surface 38, and the outer peripheral surface of the second flange portion 106 is the second operation surface 108, and the first operation surface 38 and the second operation surface 108 have shapes other than cylindrical. Therefore, by holding the first and second flange portions 36, 106 with the fingers in contact with the first operation surface 38 and the second operation surface 108, the hand is less likely to slip when applying a force in the torsional direction. In particular, in this embodiment, the first and second operation surfaces 38, 108 have a shape that provides multiple curved surfaces in the circumferential direction that are concave toward the outer periphery, making it easy to apply force with the fingers.

[0070] The first puncture member 56, which is positioned circumferentially relative to the first barrel 18, and the second puncture member 58, which is positioned circumferentially relative to the second barrel 88, rotate relative to each other in accordance with the relative rotation of the first barrel 18 and the second barrel 88. The relative rotation of the first puncture member 56 and the second puncture member 58 releases the threaded engagement between the female luer 64 of the first puncture member 56 and the luer lock portion 76 of the second puncture member 58, thereby releasing the connection between the first puncture member 56 and the second puncture member 58. The relative rotation direction of the first barrel 18 and the second barrel 88 is the same direction as the threaded engagement between the female luer 64 and the luer lock portion 76 of the double-ended needle 54.

[0071] When the threaded connection between the first puncture member 56 and the second puncture member 58 is released, it becomes possible to pull the second barrel 88 out of the first barrel 18. That is, when the second barrel 88 is pulled toward the second side while the first barrel 18 is positioned, the second barrel 88, which is not positioned axially relative to the first barrel 18, moves toward the second side.

[0072] The first puncturing member 56 is positioned in the axial direction with respect to the first barrel 18 by engagement between the locking protrusion 68 and the first locking piece 48 of the first axial locking portion 116, and the first detachment mechanism that prevents the first puncturing member 56 from coming off the first barrel 18 is configured by the first axial locking portion 116. This prevents the first puncturing member 56 from coming off from the first barrel 18 to the second side when the second barrel 88 is pulled out of the first barrel 18.

[0073] The second puncturing member 58 is positioned axially relative to the second barrel 88 by engagement between the outer peripheral protrusion 110 and the second locking piece 84 at the second axial locking portion 120, and the second axial locking portion 120 constitutes a second retention mechanism that prevents the second puncturing member 58 from coming off the second barrel 88. As a result, the second puncturing member 58 moves toward the second side integrally with the second barrel 88 as the second barrel 88 moves toward the second side. Therefore, as shown in FIG. 12 , the second puncturing member 58 separates from the first barrel 18 together with the second barrel 88, while keeping the second puncturing needle 70 inserted into the second cartridge 86.

[0074] As described above, the drug co-injection kit 10 includes a first retention mechanism that prevents the first puncturing member 56 from coming off the first barrel 18, and a second retention mechanism that prevents the second puncturing member 58 from coming off the second barrel 88 in a puncturing state in which the first and second puncturing needles 60, 70 have penetrated the first and second elastic caps 26, 96. Therefore, after the first puncturing member 56 and the second puncturing member 58 are threadably disconnected, the first puncturing member 56 and the second puncturing member 58 can be separated by a simple operation of pulling the first barrel 18 and the second barrel 88 outward in the axial direction, separating them from each other. The administration syringe 124, in which the second puncturing member 58 is attached to the tip portion of the second assembly 14, can then be obtained independently of the first barrel 18.

[0075] When the threaded engagement between the luer lock portion 76 and the female luer 64 of the first puncture member 56 is released, the second puncture member 58 moves slightly toward the second side relative to the first puncture member 56. Because the engagement between the male luer 74 and the female luer 64 is released by this slight movement accompanying the release of the threaded engagement, the tensile force exerted between the first barrel 18 and the second barrel 88 can be small, reducing the risk of damage or the like caused by the application of a large tensile force.

[0076] Note that the first cartridge 16 and the first barrel 18 are prevented from being separated by a first positioning mechanism that axially engages the first fixing member 28 with the first positioning pieces 40, 40, and the second cartridge 86 and the second barrel 88 are prevented from being separated by a second positioning mechanism that axially engages the second fixing member 100 with the second positioning pieces 114, 114. As a result, for example, when separating the second barrel 88 from the first barrel 18, the second cartridge 86 is prevented from falling off the second barrel 88, and the administration syringe 124 is placed in a state where it is equipped with the second cartridge 86 that contains the administered medicinal solution.

[0077] Furthermore, by positioning the second cartridge 86 and the second barrel 88, the second puncture needle 70 of the second puncture member 58, which separates integrally with the second barrel 88, is held in a punctured state in the second elastic cover 96 that seals the opening of the second cartridge 86, thereby preventing the second puncture needle 70 from unintentionally coming out of the second elastic cover 96, etc.

[0078] As shown in FIG. 13 , an administration hollow needle 126 is attached to the administration syringe 124 removed from the first barrel 18. The administration hollow needle 126 includes a metal needle body 128 and a connector 130 that is provided on the base end side of the needle body 128, is formed of synthetic resin, or the like, and has a female luer taper on its inner circumferential surface. The administration hollow needle 126 can be attached to the administration syringe 124 by mating and connecting the connector 130 to the male luer 74 of the second puncture member 58. Because the administration syringe 124 has the male luer 74 at its tip portion, a general hollow needle for a syringe can be used as the administration hollow needle 126. The connector 130 of this embodiment has a male thread on the outer circumferential surface of the base end and is screwed into the luer lock portion 76. The administration hollow needle 126 may be included in the drug co-injection kit 10, but may also be prepared separately from the drug co-injection kit 10.

[0079] Then, hollow needle 126 for administration attached to syringe 124 for administration is inserted into the patient, and second plunger 94 of syringe 124 for administration is pushed in, whereby the medicinal liquid to be administered in second cartridge 86 is administered to the patient.

[0080] According to the drug co-injection kit 10 configured in accordance with this embodiment, the double-ended needle 54 includes a separable first puncture member 56 and a separable second puncture member 58, and the second puncture member 58 separates from the first puncture member 56 and the first barrel 18 together with the second barrel 88 while remaining punctured in the second elastic cap 96. Therefore, when attaching the hollow administration needle 126 to the administration syringe 124 that has been separated from the first barrel 18, there is no need to re-puncture the second elastic cap 96, and a hollow needle with only one needle tip can be used as the hollow administration needle 126. Therefore, compared to using a hollow administration needle with a conventional structure having needle tips on both sides, the attachment of the hollow administration needle 126 to the administration syringe 124 can be performed more safely.

[0081] Even after administration syringe 124 is separated, double-ended needle 54 is maintained in a state in which first puncture needle 60 is punctured into first elastic cover 26 and second puncture needle 70 is punctured into second elastic cover 96. Therefore, there is no risk of touching the needle tip of double-ended needle 54 after administration syringe 124 is separated, thereby improving safety.

[0082] The first puncture member 56 and the second puncture member 58 are connected by fitting the female luer 64 and the male luer 74 together, and the hollow administration needle 126 is connected using the male luer 74 of the second puncture member 58 that has been separated from the first puncture member 56. By providing the second puncture member 58 with a standardized male luer 74, a general hollow syringe needle equipped with a connector 130 having a female luer taper can be used as the hollow administration needle 126.

[0083] The connecting portion of second puncture member 58 with connector 130 is male luer 74, and the outer peripheral surface of male luer 74, which does not come into contact with the administered medicinal liquid during the mixing operation of the first and second drugs, fits into the inner peripheral surface of connector 130. This prevents the mating surfaces of male luer 74 and connector 130 from becoming easily disconnected due to adhesion of the administered medicinal liquid.

[0084] First puncture member 56 and second puncture member 58 are connected by threaded engagement of female luer 64 and luer lock portion 76, and the connection between first puncture member 56 and second puncture member 58 can be easily released by a twisting operation. In addition, hollow needle 126 for administration is fixed using luer lock portion 76 of second puncture member 58 separated from first puncture member 56, preventing unintentional detachment of hollow needle 126 for administration from syringe 124 for administration.

[0085] Although the embodiments of the present invention have been described in detail above, the present invention is not limited to those specific descriptions. For example, the first assembly 12 and the second assembly 14 may be connected in advance. In this case, the first assembly 12 and the second assembly 14 may be connected by, for example, using a separate cylindrical collar member to connect the connecting sides of the first assembly 12 and the second assembly 14 facing each other, or by extending the needle accommodating portion 42 side of the first barrel 18 in the axial direction and connecting it to the second barrel 88. This allows the first assembly 12 and the second assembly 14 to be connected in a position where the first puncture needle 60 does not puncture the first elastic cover 26 and the second puncture needle 70 does not puncture the second elastic cover 96.

[0086] The first puncturing member 56 and the second puncturing member 58 are not necessarily connected by screwing. For example, the first puncturing member 56 and the second puncturing member 58 may be connected by an axial locking structure, and the locking may be released by the action of a tensile force or by relative rotation in the circumferential direction. Note that if the connection between the first puncturing member 56 and the second puncturing member 58 is released by pulling, the first and second rotation limiting mechanisms may be omitted, and relative rotation between the first puncturing member 56 and the first barrel 18 and relative rotation between the second puncturing member 58 and the second barrel 88 may be permitted. Furthermore, the separable connection structure between the first puncturing member 56 and the second puncturing member 58 is not limited to a direct connection between the two members, but may be achieved indirectly via another connecting member. Furthermore, instead of connecting the first puncturing member 56 and the second puncturing member 58 by screwing, a connection structure using a connecting pin that can be inserted between the two members from the side and can be removed may also be used.

[0087] In the above embodiment, an example was shown in which the first removal prevention mechanism is configured by axial locking (first axial locking portion 116) between the first locking piece 48 and the locking protrusion 68, but the specific structure of the first removal prevention mechanism is not particularly limited as long as it can prevent the first puncture member 56 from coming off the first barrel 18. Specifically, for example, the first removal prevention mechanism can also be configured by providing a slip stopper that increases axial frictional resistance between the first tubular portion 66 and the needle accommodating portion 42. As with the first removal prevention mechanism, the specific structure of the second removal prevention mechanism is also not limited. Furthermore, once the first puncturing member 56 and the second puncturing member 58 are placed in a puncturing communication state with the first cylinder 20 (first elastic cover 26) or the second cylinder 90 (second elastic cover 96), they may continue to be maintained in this puncturing communication state. Therefore, for example, a fastening means such as adhesive or double-sided tape may be used to fix the first puncturing member 56 and the second puncturing member 58 in a puncturing communication state with the first cylinder 20 or the second cylinder 90, thereby forming a removal prevention mechanism that prevents the first puncturing member 56 and the second puncturing member 58 from coming off the first cylinder 20 or the second cylinder 90.

[0088] In the above embodiment, an example was shown in which the first rotation limiting mechanism is configured by circumferential locking (first circumferential locking portion 118) between the rotation limiting rib 52 and the locking protrusion 68, but the specific structure of the first rotation limiting mechanism is not particularly limited as long as it is capable of limiting the relative rotation between the first barrel 18 and the first puncturing member 56 when the first barrel 18 and the second barrel 88 rotate relative to each other. Specifically, for example, the first rotation limiting mechanism can also be configured by providing a non-slip surface that increases circumferential frictional resistance between the first tubular portion 66 and the needle accommodating portion 42. Note that, like the first rotation limiting mechanism, the specific structure of the second rotation limiting mechanism is also not limited.

[0089] In the above embodiment, the second puncture member 58 is described as having a male luer 74 conforming to ISO 80369, which can be connected to a hollow needle for a general syringe. However, for example, the connector of the second puncture member and the hollow needle for administration may be connected by a dedicated connection mechanism, thereby eliminating the need for a hollow needle for a general syringe. This allows, for example, a dedicated hollow needle for administration to be included in a drug co-injection kit, thereby providing a hollow needle for administration that is more suitable for the administered drug solution and preventing frequent use of the hollow needle for administration. Specifically, for example, the first puncture member may have a cylindrical female threaded portion with a female thread on its inner surface instead of the female luer 64, and the second puncture member may have a cylindrical male threaded portion with a male thread on its outer surface instead of the male luer 74. By threading the female threaded portion and the male threaded portion together, the first puncture member and the second puncture member can be separably connected, allowing only a hollow needle for administration having a connector that can be threaded onto the male threaded portion to be connected.

[0090] It is desirable that the first cartridge 16 be entirely housed in and protected by the first barrel 18 as in the above embodiment, but, for example, the base end portion may protrude toward the base end from the first barrel 18. Similarly, the second cartridge 86 does not need to be entirely housed in the second barrel 88, and may be exposed from the second barrel 88.

[0091] The first and second barrels 18, 88 may be cylindrical as a whole, and may be provided with slits or windows so that the first and second cartridges 16, 86 and the double-ended needle 54 are partially exposed in the circumferential direction, for example.

[0092] When the first puncture member 56 and the second puncture member 58 are connected by screwing and can be separated by unscrewing the screwing, the operation surfaces 38, 108, which are the outer peripheral surfaces of the first flange portion 36 and the second flange portion 106, are preferably not cylindrical so as to easily apply a torsional force. However, the operation surfaces 38, 108 are not limited to the shape of a combination of concave surfaces shown in the above embodiment. For example, operation protrusions protruding outward from the first and second barrels 18, 88 can be partially provided in the circumferential direction, and the circumferential end surfaces of the operation protrusions can be used as operation surfaces to be pressed by fingers. The operation surfaces do not necessarily have to be located at the base ends of the first and second barrels 18, 88. For example, they may be provided midway along the axial direction of the first and second barrels 18, 88. The present invention originally includes all of the inventions described below in (i) to (x), and the configurations and effects thereof will be described below. The present invention provides (i) A drug co-injection kit comprising: a first assembly in which a first cartridge, the first cartridge comprising a piston-type syringe containing a first drug and having a tip opening sealed with a first elastic lid, is inserted into a first cylindrical barrel; a second assembly in which a second cartridge, the second cartridge comprising a piston-type syringe containing a second drug and having a tip opening sealed with a second elastic lid, is inserted into a second cylindrical barrel; and double-ended needles pierced through the first elastic lid and the second elastic lid, respectively, to communicate between the first cartridge and the second cartridge, a drug co-injection kit in which the double-ended needle has a structure in which a first puncturing member having a first puncturing needle to be punctured into the first elastic cover and a second puncturing member having a second puncturing needle to be punctured into the second elastic cover are separably connected, a first retention mechanism is provided to prevent the first puncturing member from coming off the first barrel when the first puncturing needle has punctured the first elastic cover, and the second puncturing member that has punctured the second elastic cover can be separated from the first puncturing member and the first barrel together with the second barrel; (ii) The drug co-injection kit according to (i), wherein the second puncture member has a communicating portion that is connected to the first puncture member and that communicates between the first puncture needle and the second puncture needle and is a luer portion having a luer taper. (iii) The drug co-injection kit according to (i) or (ii), wherein the first barrel is provided with a needle accommodating portion that extends further distally than the first cartridge and accommodates the double-ended needle; (iv) The drug co-injection kit according to any one of (i) to (iii), wherein the first puncture member includes a first cylindrical portion surrounding the outer periphery of the first puncture needle, and the first retention mechanism is configured by a first axial locking portion that is locked in the axial direction between the first cylindrical portion and the first barrel when the first puncture needle is in a state of puncturing the first elastic cover body. (v) The drug co-infusion kit according to any one of (i) to (iv), wherein the first puncture member and the second puncture member are screwed together in the double-ended needle, a first rotation limiting mechanism is provided that limits the relative rotation between the first barrel and the first puncture member when the first puncture needle is in a state of puncturing the first elastic cover, and a second rotation limiting mechanism is provided that limits the relative rotation between the second barrel and the second puncture member when the second puncture needle is in a state of puncturing the second elastic cover, and the relative rotation between the second barrel and the first barrel is exerted on the first puncture member and the second puncture member to release the screw engagement, and the second puncture member is separated from the first puncture member and the first barrel together with the second barrel. (vi) The drug co-injection kit according to (v), wherein the first puncture member includes a first cylindrical portion surrounding the outer periphery of the first puncture needle, and the first rotation limiting mechanism is configured by a first circumferential locking portion that is locked in the circumferential direction between the first cylindrical portion and the first barrel when the first puncture needle is in a state where it has punctured the first elastic cover. (vii) The drug co-injection kit according to (v) or (vi), wherein the second puncture member has a second cylindrical portion that is fitted onto the tip of the second barrel when the second puncture needle is in a state of puncturing the second elastic cover, and the second rotation limiting mechanism is constituted by a second circumferential locking portion that is locked circumferentially between the second cylindrical portion and the second barrel when the second puncture needle is in a state of puncturing the second elastic cover; (viii) A drug co-injection kit according to any one of (i) to (vii), wherein the second puncture member has a second cylindrical portion that is fitted onto the tip of the second barrel when the second puncture needle is in a state of puncturing the second elastic cover, and a second axial locking portion that is axially locked between the second cylindrical portion and the second barrel constitutes a second removal prevention mechanism that prevents the second puncture member from being removed from the second barrel; (ix) A drug co-injection kit according to any one of (i) to (viii), comprising a first positioning mechanism that positions the first barrel and the first cartridge relative to each other in the axial direction, and a second positioning mechanism that positions the second barrel and the second cartridge relative to each other in the axial direction. (x) A drug co-injection kit according to any one of (i) to (ix), wherein the first barrel is provided with a first flange-shaped portion that protrudes outward, the second barrel is provided with a second flange-shaped portion that protrudes outward, and the outer surfaces of the first flange-shaped portion and the second flange-shaped portion are surfaces that can be operated by fingers. This includes inventions relating to: In the invention described in (i) above, the hollow administration needle used to administer the mixed medicinal solution to a patient is separated from the first puncture member and the first barrel together with the second barrel while the second puncture member of the double-ended needle is punctured into the second elastic cap. This eliminates the need for a needle tip to penetrate the second elastic cap. Therefore, compared to conventional hollow administration needles with needle tips on both sides, safety in handling the hollow administration needle is improved. Because the first puncture member and the second puncture member are separable, the first barrel (first cartridge) and the second barrel (second cartridge) are separated from each other while the first puncture needle is punctured into the first elastic cap and the second puncture needle is punctured into the second elastic cap. Therefore, even during operations such as removing the second cartridge, the first puncture needle and the second puncture needle are not accidentally exposed, and contact with the needle tip of the double-ended needle can be prevented. In the invention described in (ii) above, the second puncturing member separated from the first cartridge while punctured by the second elastic cover has a luer part, which makes it possible to use, for example, a general hollow syringe needle equipped with a connector having a luer taper that is attached to the tip of a syringe as the hollow administration needle. It is desirable that the luer part be a luer specified in ISO 80369. Furthermore, by providing the first puncturing member with a structure connectable to the luer part, it is possible to easily achieve separable connection between the first puncturing member and the second puncturing member. In the invention described in (iii) above, the double-ended needle is housed in the needle housing of the first barrel, making it difficult for unintended contact to occur with the double-ended needle. For example, even when the second barrel and the second cartridge are separate from the first barrel and the first cartridge, it is difficult for the tip of the second puncture needle of the double-ended needle to be touched, improving safety. In addition, the double-ended needle can be handled integrally with the first assembly, making it easier to handle. In the invention described in (iv) above, the first puncture member can be prevented from coming off the first barrel by the first axial locking portion with a simple structure. In the invention described in (v) above, the first puncture member and the second puncture member can be easily unscrewed by twisting the first barrel and the second barrel relative to each other. Because the first puncture member and the second puncture member can be separated by unscrewing them, there is no need to apply a large tensile force, and unintended separation, such as the first puncture member coming off the first barrel together with the second puncture member, can be prevented. In the invention described in (vi) above, the first rotation limiting mechanism is configured using the first cylindrical portion that surrounds the outer periphery of the first puncture needle, so that a large resistance (torque) against rotation can be obtained. In the invention described in (vii) above, the second rotation limiting mechanism is configured using the second cylindrical portion that surrounds the outer periphery of the second puncture needle, so that a large resistance (torque) against rotation can be obtained. In the invention described in (viii) above, the second puncturing member and the second barrel are prevented from separating by the second anti-detachment mechanism, and therefore the second puncturing member can be separated from the first barrel together with the second barrel and the second cartridge. In the invention described in (ix) above, separation of the first cartridge and the first barrel is prevented, and separation of the second cartridge and the second barrel is prevented, and the first cartridge and the second cartridge are reliably separated as the first barrel and the second barrel are separated. Furthermore, by positioning the second cartridge and the second barrel, the second puncture needle of the second puncture member that separates integrally with the second barrel is maintained in a state of being inserted into the second elastic cover that seals the opening of the second cartridge. In the invention described in (x) above, the first barrel and the second barrel can be easily separated by holding the operating surfaces of the first flange and the second flange. In particular, when the first puncture member and the second puncture member are connected by screwing and the first puncture member and the second puncture member are separated by twisting the first barrel and the second barrel, as in the fifth to seventh aspects, the separation can be performed with a relatively small input by applying a twisting force to the large-diameter first flange and the second flange. [Explanation of symbols]

[0093] 10 Drug Mixture Kit 12 1st assembly 14 Second assembly 16 First Cartridge 18 First Barrel 20 No. 1 cylinder 22 First plunger 24 Containment Area 1 26 First elastic cover 28 First fixing member (first positioning mechanism) 30 1st tip through hole 32 First tip rubber 34 First cartridge storage section 36 First collar 38 1st operation surface (operation surface) 40 First positioning piece (first positioning mechanism) 42 needle storage section 44 Position regulation part 46 First window section 48 1st locking piece 50 Positioning rib 52 Rotation limiting rib 54 Double ended needle 56 First puncture member 58 second puncture member 60 1st puncture needle 62 First flange-shaped portion 64 Female Lure 66 First cylindrical section 68 Locking protrusion 70 Second puncture needle 72 Second flange-shaped portion 74 Male Lure (Lure Section) 76 Luer lock part 78 Second cylindrical section 80 Inner peripheral protrusion 82 Second window section 84 Second locking piece 86 Second Cartridge 88 Second Barrel 90 No. 2 cylinder 92 Second Containment Area 94 Second plunger 96 Second elastic cover 98 Second tip rubber 100 second fixing member (second positioning mechanism) 102 2nd tip through hole 104 second cartridge storage section 106 Second collar 108 2nd operation surface (operation surface) 110 Outer periphery protrusion 112 Window-like opening 114 Second positioning piece (second positioning mechanism) 116 First axial locking part (first retaining mechanism) 118 First circumferential locking portion (first rotation limiting mechanism) 120 Second axial locking part (second retaining mechanism) 122 Second circumferential locking portion (second rotation limiting mechanism) 124 Administration syringe 126 Hollow needle for administration 128 Needle body 130 Connector

Claims

1. a first assembly in which a first cartridge including a piston-type syringe containing a first drug and having a tip opening sealed with a first elastic lid is inserted into a cylindrical first barrel; a second assembly in which a second cartridge including a piston-type syringe containing a second drug and having a distal end opening sealed with a second elastic lid is inserted into a cylindrical second barrel; a double-ended needle that is pierced through the first elastic cover and the second elastic cover, respectively, to connect the first cartridge and the second cartridge to each other; A drug co-injection kit comprising: the double-ended needle has a connecting structure in which a first puncturing member having a first puncturing needle to be punctured into the first elastic cover and a second puncturing member having a second puncturing needle to be punctured into the second elastic cover are separably connected; a first retention mechanism is provided that prevents the first puncture member from coming off the first barrel by engaging the first puncture member with the first barrel, thereby maintaining the first puncture needle in a state of puncturing the first elastic cover; The connecting structure has a screw structure for connecting the first puncturing member and the second puncturing member, and the screw connection is released by rotation of the first puncturing member and the second puncturing member relative to each other, thereby allowing the second puncturing member to be separated from the first puncturing member, and the second assembly in which the second puncturing needle of the second puncturing member has punctured the second elastic cover can be removed from the first assembly in which the first puncturing member is locked to the first barrel by the first removal prevention mechanism; the second puncture member has a second cylindrical portion that is engaged with and fitted onto the tip end portion of the second barrel at a puncture position of the second puncture needle in the second elastic cover, the first barrel has a cylindrical needle accommodating portion that extends distally beyond the first cartridge and accommodates the double-ended needle and the second cylindrical portion; The needle accommodating section has a cylindrical section into which the tip of the second barrel can be moved and inserted, and the second puncture needle is inserted into the second elastic lid body inside the needle accommodating section.

2. a communication portion of the second puncture member that is connected to the first puncture member and that communicates between the first puncture needle and the second puncture needle is a luer portion having a luer taper; 2. The drug co-injection kit according to claim 1, wherein the lure part is a lure part for attaching a hollow needle.

3. the first puncture member includes a first cylindrical portion surrounding the outer periphery of the first puncture needle; The drug injection kit according to claim 1 or 2, wherein the first retention mechanism is constituted by a first axial locking portion that is axially locked between the first cylindrical portion and the first barrel when the first puncture needle is inserted into the first elastic cover.

4. The first puncture member and the second puncture member are threadedly engaged in the double-ended needle, a first rotation limiting mechanism that limits relative rotation between the first barrel and the first puncturing member when the first puncturing needle is in a state of puncturing the first elastic cover, a second rotation limiting mechanism that limits relative rotation between the second barrel and the second puncturing member when the second puncturing needle is in a state of puncturing the second elastic cover, The drug co-injection kit according to any one of claims 1 to 3, wherein the relative rotation between the second barrel and the first barrel is applied to the first puncture member and the second puncture member, thereby releasing the threaded engagement, and the second puncture member is separated from the first puncture member and the first barrel together with the second barrel.

5. the first puncture member includes a first cylindrical portion surrounding the outer periphery of the first puncture needle; The drug injection kit according to claim 4, wherein the first rotation limiting mechanism is constituted by a first circumferential locking portion that is locked circumferentially between the first cylindrical portion and the first barrel when the first puncture needle is inserted into the first elastic cover.

6. the second puncture member includes a second cylindrical portion that is fitted onto the tip end portion of the second barrel when the second puncture needle is in a state of puncturing the second elastic cover, The drug injection kit according to claim 4 or 5, wherein the second rotation limiting mechanism is constituted by a second circumferential locking portion that is locked circumferentially between the second cylindrical portion and the second barrel when the second puncture needle is inserted into the second elastic cover.

7. the second puncture member includes a second cylindrical portion that is fitted onto the tip end portion of the second barrel when the second puncture needle is in a state of puncturing the second elastic cover, The drug co-injection kit according to any one of claims 1 to 6, wherein a second axial locking portion that is axially locked between the second cylindrical portion and the second barrel constitutes a second retention mechanism that prevents the second puncture member from coming out of the second barrel.

8. A first positioning mechanism that positions the first barrel and the first cartridge relative to each other in the axial direction, and a second positioning mechanism that positions the second barrel and the second cartridge relative to each other in the axial direction. A drug co-injection kit according to any one of claims 1 to 7.

9. The first barrel is provided with a first flange portion that protrudes outward, The second barrel is provided with a second flange portion that protrudes outwardly, The drug co-injection kit according to any one of claims 1 to 8, wherein the outer peripheral surfaces of the first flange portion and the second flange portion are surfaces that can be operated by fingers.

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