Container adapter for syringe, double stopper with adapter for syringe, corresponding container and sampling method

Abstract

This container adapter (10) for a syringe comprises a main body (12), having a lateral configuration suitable for entering by force into a container opening while being adapted to the complementary shape of an inner lateral wall of this container opening, and a through-hole (22), formed longitudinally in the main body (12), for insertion of a sampling endpiece of the syringe. It further comprises a head stopper (24), integral with the main body (12), having an insertion pin (26) shaped to enter by force into the through-hole (22) and seal the latter hermetically.

Description

Syringe container adapter, double cap with syringe adapter, corresponding container and sampling method

[0001] The present invention relates to a syringe container adapter and a double stopper for a syringe container adapter. It also relates to a container comprising such an adapter or such a double stopper. It further relates to a method for withdrawing fluid from such a container using a syringe.

[0002] The invention applies more particularly to a syringe container adapter, comprising: a main body, having a lateral conformation suitable for forcing into a container opening while being adapted to the complementary shape of an inner lateral wall of this container opening; and a through hole, formed longitudinally in the main body, for the insertion of a syringe sampling tip.

[0003] Such an adapter is generally used in healthcare settings for the direct withdrawal of fluid from a container using a syringe with a sampling tip. However, besides being designed only for very specific hospital applications, such as withdrawing medication or nutritional fluids for enteral feeding using a dedicated enteral syringe, it is also unsuitable for home use where hygiene protocols are generally not as strictly followed. For example, it is not compatible with a standard commercially available nasal saline syringe, which has a capacity of ten milliliters and a smaller diameter than an enteral syringe.

[0004] What is currently available for nasal irrigation for adults, children, or babies from six months old is a container without a special adapter, in the form of a bottle of saline solution, for example, 0.9% NaCl (sodium chloride), and a standard ten-milliliter syringe. The syringe can optionally be fitted with a soft, detachable nasal tip for gentler contact with a baby's nostril and / or for hygiene reasons. The bottle of saline solution, for example, is brand B.Braun, Fresenius, Versol, L2N Pharma or Evolupharm (registered trademarks) is generally not marketed for use as a nasal wash, with the exception of the L2N Pharma bottle, and is not designed to facilitate sampling with a nasal syringe, with the notable exception of the Evolupharm bottle which is supplied with a container or small pouring cup integrated into the external cap to transfer some of its contents into it before sampling with a syringe.

[0005] Historically, nasal irrigation was typically performed using five-milliliter vials. However, in recent years, as nasal syringes have become recommended by healthcare professionals as part of a new irrigation method deemed more effective in preventing contamination, some manufacturers of saline solution for wound cleaning have capitalized on this trend by selling bottles for nasal irrigation. These bottles, however, have not been adapted for this purpose, notably by failing to allow for direct dispensing from the bottle while adhering to minimum hygiene and contamination control standards.

[0006] As a result, most users today get into the habit of taking the saline solution directly from the bottle or into a cup.

[0007] This raises two major problems: firstly, users may develop the bad habit of drawing up the solution with the syringe and its nasal tip, then returning it to the cup or bottle, contaminating the remaining saline solution; secondly, most users are already in the habit of pouring the solution into a container larger than the volume in the cup because this allows them to draw up more than one dose with a single syringe, thus increasing the risk of waste. This also often results in contamination of the solution by the syringe's nasal tip, increasing the risk of contamination for the person—adult, child, or baby—receiving the nasal injection. Furthermore, young children may be restless during nasal irrigation, which can lead to spilling the saline solution bottle.Furthermore, it is not easy to take the desired quantity directly from the bottle when it is far from full.

[0008] It may therefore be desirable to provide a syringe container adapter that would allow us to overcome at least some of the aforementioned problems and constraints.

[0009] A syringe container adapter is therefore proposed, comprising: a main body, having a lateral conformation suitable for forcing into a container opening while being adapted to the complementary shape of an inner lateral wall of this container opening; a through hole, formed longitudinally in the main body, for the insertion of a syringe sampling tip; and a cap, or stopper, integral with the main body, having an insertion pin shaped to force into the through hole and seal it hermetically.

[0010] Thus, the adapter acts as an easily manipulated internal stopper, allowing the selective insertion of a syringe tip when open and sealing the container opening when closed. Furthermore, it is within the capabilities of a person skilled in the art to design it according to the standard of the syringes used, for example, 10-milliliter syringes with a flexible, detachable nasal tip for nasal irrigation, ensuring optimal, secure, and airtight sampling, i.e., without risk of contamination, leakage, or waste. In other words, it is within the capabilities of a person skilled in the art to size the through hole, particularly its diameter, to accommodate the size of the intended syringes, especially the diameter of their sampling tip.Finally, such an adapter can be easily added to the standard screw cap of any known physiological saline bottle, thus ensuring a double seal of the container concerned by this addition.

[0011] The following objectives are therefore met in particular for a specific non-limiting application of nasal washing: avoid any risk of contamination of the physiological serum contained in the bottle, facilitate the filling of nasal syringes, in particular those of ten millilitres, prevent the contents of the container from spilling during nasal washing (for example between the treatment of two nostrils) or during transport, carry out a nasal wash safely, avoid waste.

[0012] In addition, in the particular case of an adapter design conforming to the standard for syringes with a detachable nasal tip, any contact between the nasal tip and the contents of the container can be avoided, as the device requires that the nasal tip in contact with the nasal mucosa be removed in order to safely collect this content using the syringe collection tip.

[0013] Optionally, the cap with a head, or cap, has a head configured as a circular disc forming a valve, or a circular base forming a lid, in the center of which the insertion pin extends in a direction essentially normal to this circular disc, or circular base.

[0014] Optionally, the cap with head, in particular the head of the cap with head, and the main body are connected together by a flexible tab, or ribbon, the whole being formed from the same elastic material by molding.

[0015] Optionally, the lateral conformation of the main body also includes a general cylindrical shape for press-fit insertion into a corresponding cylindrical neck of the container opening, for example by means of at least one press-fit collar.

[0016] Optionally also: the main body has an outside diameter, excluding neck(s), adapted to the inside diameter of a bottle neck, for example between 22.2 mm and 23 mm, preferably equal to 22.6 mm + / - 0.1 mm for a conventional physiological saline bottle; and the through hole has a diameter adapted to that of a syringe sampling tip, for example between 3.9 mm and 4 mm, preferably equal to 3.95 mm + / - 0.03 mm for a conventional ten millilitre nasal syringe.

[0017] Optionally, the main body also has a curved face, in particular with a concave, linear or convex slope, intended to be oriented towards the outside of the opening of the container, in the bottom of which the through hole is drilled, this curved face being configured to receive as a stop the head of the cap when the insertion pin extends into the through hole.

[0018] A double cap with syringe container adapter is also proposed, intended to seal an opening in the container, comprising: a syringe container adapter according to the present invention, forming a first inner cap of this double cap; and a second outer cap intended to cooperate with an outer side wall of the opening to seal it while covering the first inner cap.

[0019] Optionally, the second outer cap has an internal thread cooperating with an external thread of the container opening.

[0020] Also proposed is a container, containing or intended to contain a fluid to be taken by syringe, comprising an opening and an adapter according to the present invention, or a double cap with adapter according to the present invention.

[0021] A method for withdrawing fluid from a container according to the present invention using a syringe is also proposed, comprising the following steps: unscrewing, where applicable, the second outer cap to release the opening of the container, removing the insertion pin of the first inner cap to release the through hole of the adapter and removing, where applicable, a detachable tip of the syringe to release its sampling tip; forcibly inserting the sampling tip of the syringe into the through hole of the adapter from the top; inverting the container and the syringe inserted in the adapter, then aspirating a desired quantity of fluid using the syringe from the bottom; inverting the container and the syringe filled with the desired quantity of fluid again, then removing the syringe from the top;Force the insertion pin of the first inner cap into the through hole of the adapter, screw on, if necessary, the second outer cap to seal the opening of the container and, if necessary, attach the detachable tip of the syringe to its sampling tip.

[0022] The invention will be better understood with the aid of the following description, given solely by way of example and made with reference to the accompanying drawings in which: a schematic perspective view of a syringe container adapter, according to a first embodiment of the present invention; a schematic side view of the adapter, including an indication of a set of dimensions compatible with the use of a standard nasal syringe and a commercially available physiological saline bottle; a schematic top view of the adapter, with the same dimensions as the; a schematic perspective view of a syringe container adapter, according to a second embodiment of the present invention; a schematic side and cross-section of the adapter; a schematic bottom view of the adapter;Figure 1 schematically represents, in front view, a double-capped container, according to an embodiment of the present invention; Figure 2 illustrates the successive steps of a method for withdrawing, using a syringe, a fluid contained in a container such as that of Figure 3, according to an embodiment of the present invention; Figure 3 illustrates a first step of the method of withdrawal; Figure 4 illustrates a first intermediate step of the method of withdrawal; Figure 5 illustrates a second intermediate step of the method of withdrawal; and Figure 6 illustrates a final step of the method of withdrawal.

[0023] The adapter 10, shown in perspective in Figure 1, comprises a main body 12, essentially cylindrical in shape, corresponding to a complementary cylindrical shape of an inner lateral wall of a container opening into which it is intended to be press-fitted for a hermetic lateral sealing of the container. When the container is a bottle or flask, the main body 12 of the adapter 10 is thus shaped to press-fit into its opening neck. The press-fit insertion of the main body 12 into the container opening can be achieved by a negative clearance between its outer diameter and the inner diameter of the opening and / or by means of at least one collar formed as an annular projection on its cylindrical lateral wall. Two collars 14 and 16 are thus illustrated in Figure 1.

[0024] The main body 12 has a hollow circular base 18, not visible on the image, intended to face inwards towards the container, and an opposite solid face 20, also circular but curved and intended to face outwards from the container opening. This curve may be concave, linear (i.e., frustoconical in cross-section), or convex. A through hole 22, formed longitudinally in the main body 12, is drilled at the bottom of this curve for the insertion of a syringe tip, for example, the tip of a nasal syringe. The curve facilitates the insertion of the nasal syringe tip into the through hole by guiding it towards it.

[0025] The adapter 10 further includes a cap with a head 24 having: an insertion pin 26 shaped to enter forcefully into the through hole 22 of the main body 12 and seal it hermetically: the forceful insertion of this pin 26 can be achieved by a negative clearance between its outer diameter and the diameter of the through hole 22 and / or by means of at least one collar formed in annular projection on its cylindrical side wall (a collar 28 is thus illustrated in the middle of the insertion pin 26); and a head configured as a circular disc 30 forming a valve, in the center of which the insertion pin 26 extends in a direction essentially normal to this circular disc 30.

[0026] The cap with head 24 is integral with the main body 12, being connected to it by a flexible, ribbon-like tab 32 extending between the circular disc 30 and a peripheral collar 34 of the curved solid face 20 of the main body 12. The assembly consisting of the main body 12, the cap with head 24, and the flexible tab 32 is, for example, made from an elastic material and formed by molding. Transparent polypropylene is suitable but is not the only possible material.

[0027] In the open configuration of the adapter 10 as illustrated in the figure, the flexible tab 32 and the cap with head 24 extend laterally from the collar 34, which is designed to abut against the opening of a container into which the remainder of the main body 12 of the adapter 10 is inserted. In the closed configuration of the adapter 10, the flexible tab 32 is elastically folded back on itself, and the insertion pin 26 of the cap with head 24 is inserted into the through hole 22 to seal it hermetically. The head of the insertion pin 26, in its circular pellet-like configuration 30, abuts against the curved face 20 of the main body 12.This results in two advantages: the opening and closing of this first inner stopper formed by the adapter 10 is particularly simple and can be performed quickly with one hand, or even with one finger; in closed configuration, the adapter 10 is particularly compact, so that it can itself be covered by a second conventional outer stopper intended to cooperate with an outer side wall of the opening of the container in question to seal it in double security.

[0028] A concrete example of the design and dimensions of adapter 10 is shown in a side view on the left and a top view on the right. It is designed to conform to the specific use of a conventional 10-milliliter nasal syringe and a commercially available saline solution bottle. Such a nasal syringe has a predominantly cylindrical, but slightly truncated conical, sampling tip with an average diameter of approximately 4.2 mm. A commercially available saline solution bottle is, for example, made of transparent polyethylene terephthalate (PET), with a half-liter capacity, a cylindrical shape, and an internal neck opening diameter of approximately 22 mm with an external thread.

[0029] The main body 12 then has an outside diameter, excluding collars 14 and 16, of between 22.2 mm and 23 mm, preferably 22.6 mm + / - 0.1 mm to ensure negative clearance for press-fit insertion of the adapter 10 into the bottle neck. Collars 14 and 16 add a peripheral thickness of approximately 1 mm, or at most 2 mm, just sufficient to ensure a tight, press-fit fit into the container opening. The collar 34 has an outside diameter of between 24.2 mm and 25 mm, preferably 24.6 mm + / - 0.1 mm. The main body 12 further has a longitudinal thickness of between 10 mm and 11 mm, preferably equal to 10.4 mm + / - 0.1 mm, including a collar thickness 34 of about 1 mm, a distance between collar 34 and collar 16 of about 2.7 mm and a distance between the two collars 14, 16 of about 2.7 mm also.

[0030] The circular base 18 is hollowed out with a recess centered on an inner diameter between 17.5 mm and 18.5 mm, preferably equal to 18 mm + / - 0.1 mm, and on a depth of about 4.3 mm.

[0031] In the non-limiting example shown, the curved solid face 20 has a frustoconical cross-section, and therefore a linear slope. It extends from the inside of the collar 34, over a diameter of between 19.5 mm and 20.5 mm, preferably 20 mm + / - 0.1 mm, and to a depth of approximately 3.7 mm from the outside of the collar 34 at a slope of approximately 65°. At this depth, it reaches the diameter of the through hole 22, which is between 3.9 mm and 4 mm, preferably 3.95 mm + / - 0.03 mm, i.e., very slightly less than 4 mm to ensure no leakage between the bottle and the syringe. This results in a depth of approximately 2.4 mm for the through hole 22, which has a negative clearance of approximately 0.25 mm with the average diameter of a standard nasal syringe tip. The slightly truncated conical shape of such a sampling tip also allows for progressive forceful insertion into the through hole 22.

[0032] The flexible tongue 32 has a length of approximately 7.1 mm and a thickness of approximately 0.3 mm.

[0033] The cap with head 24 has a head (circular disc 30) of about 0.7 mm thick and 11.5 mm in diameter, as well as a cylindrical insertion pin with an outside diameter between 3.9 mm and 4 mm, preferably equal to 3.95 mm + / - 0.03 mm, and a length of about 5.5 mm, including a distance between its free end and the collar 28 of about 2.3 mm.

[0034] The adapter 40, shown in perspective in Figure 1, in lateral view and in section AA in Figure 2, and in bottom view in Figure 3, differs slightly from that of Figures 1 to 3 in its profile. Its main body 42 has only one collar 44 near its flange 46 and features a narrowing R of external diameter near its circular base 48, for a more gradual press-fit insertion than in the previous embodiment. Otherwise, it is similar to the adapter 10, with a slight offset of the collar 50 of its insertion pin 52 near its free end 54, which is frustoconical or rounded.

[0035] A container 60 containing or intended to contain a fluid to be drawn by syringe, in particular a bottle of physiological saline, is illustrated on the.

[0036] This bottle 60 is fitted with a double stopper 62 according to the present invention. This double stopper 62 includes a syringe container adapter such as that 10 or 40 of Figures 1 to 3 or 4 to 6, forming a first inner stopper 64 inserted tightly and hermetically into the opening neck 66 of the bottle 60. It further includes a second outer stopper 68 with an internal thread, intended to cooperate with an external thread 70 of the opening neck 66 to seal it while covering the first inner stopper 64.

[0037] An optimized method for withdrawing a fluid from a container using a syringe will now be detailed with reference to the [reference], with some steps illustrated in Figures 9A to 9D. It is described, more specifically but without limitation, for withdrawing physiological saline from bottle 60 of the [reference] using a standard ten-milliliter nasal syringe.

[0038] In the first step 100, a bottle of physiological saline solution 60 and a standard syringe 72 with a flexible, detachable nasal tip 74 are provided. This step is illustrated by the.

[0039] During a preparation step 102, the second outer cap 68 is unscrewed from the neck 66 of the bottle 60 to free its opening, the insertion pin of the adapter forming the first inner cap 64 is removed from the through hole to free it and the detachable nasal tip 74 of the nasal syringe 72 is removed to free its sampling tip 76. The latter can then be brought close to the neck 66 of the bottle 60, as illustrated by the.

[0040] In a subsequent step 104, the sampling tip 76 of the nasal syringe 72 is forcibly inserted from above into the through hole of the adapter forming the first inner stopper 64.

[0041] Next, bottle 60 and the nasal syringe 72 inserted into the through-hole are inverted, and then the desired amount of saline solution is drawn up from the bottom using the plunger of the nasal syringe 72. The execution of this step 106 is illustrated in Figure 1. Thanks to the inverting and the adapter, saline solution can thus be drawn directly, without leakage or waste, regardless of the amount of solution contained in bottle 60.

[0042] In a subsequent step 108, the bottle 60 and the nasal syringe 72 inserted into the through hole and filled with the desired amount of physiological saline are turned upside down again, and then the nasal syringe 72 is removed from the top.

[0043] Finally, in a final step 110, the insertion pin of the adapter forming the first inner cap 64 is forced into the through hole to seal it, and the detachable nasal tip 74 is repositioned on the sampling tip 76 of the nasal syringe 72 for use. This results in the following situation. During this same step, if further sampling of physiological saline is no longer desired, the second outer cap 68 can also be screwed back onto the neck 66 of the bottle 60. It should be noted that at no time can there be any contact between the nasal tip and the drawn physiological saline solution.

[0044] It is clear that a syringe container adapter such as one of those described above, and a syringe fluid sampling method such as that described with reference to the, allow for simple, safe, hygienic and waste-free fluid sampling.

[0045] In particular, this innovation allows for the direct dispensing of saline solution through the adapter when inserted into the opening of a bottle or vial, notably for nasal irrigation, while minimizing the risk of solution contamination and simplifying nasal syringe filling for the user. Furthermore, the flip-top cap ensures a double seal on the bottle to prevent any unwanted leakage.

[0046] Furthermore, the device allows for the precise dispensing of ten milliliters of solution, without waste. This innovation eliminates the need to transfer the solution into a cup for dispensing, ensuring that the solution remains in the bottle throughout its use, thus preserving its sterility. And unlike traditional bottles without an adapter, where it is impossible to dispense the solution when the level is too low for the syringe to reach the bottom, this invention allows the solution to be dispensed regardless of the bottle's capacity by simply inverting the bottle before dispensing.

[0047] Furthermore, the following advantageous technical features should be noted: the adapter is designed to fit optimally into a bottle, but with a slight curve on its outer face to allow for optimal solution withdrawal and prevent leakage; it allows for immediate withdrawal of the solution using a ten-milliliter syringe and is equipped with a small valve providing a double closure and enabling one-handed operation; currently, no cap or bottle allows for direct withdrawal of a solution using a standard ten-milliliter syringe; the proposed adapter is specifically designed with dimensions and a shape adapted to facilitate syringe insertion without any leakage of the solution; it also ensures easy closure during use and a double closure (i.e.cap with a valve-forming head + second external cap of the bottle) during transport to prevent any leakage of the solution; the physiological serum bottle equipped with an adapter according to the invention is the only one which allows the physiological serum solution to be taken directly from the bottle and guarantees the absence of contamination of the solution.

[0048] It is also worth recalling the technical advantages of the embodiments described above: withdrawal of the physiological saline solution directly from the bottle; introduction of a syringe via the adapter without difficulty or leakage, allowing in particular the withdrawal of the solution with a standard ten millilitre syringe without leakage by guaranteeing the seal between the syringe and the bottle by the adapter; no possibility of contact between the solution and the nasal tip of the syringe during withdrawal; double flap closure to avoid the risk of leakage of the solution during use or during transport, reduction of waste of the solution: possibility of withdrawing up to the last drop contained in the bottle.

[0049] Currently, there is no commercially available device that allows for filling a nasal syringe without transferring the solution to another container and without ensuring that the user cannot draw the solution with the syringe's nasal tip in direct contact with the nasal mucosa. Nasal hygiene is essential to prevent ENT (ear, nose, and throat) infections, and improper use can lead to user contamination. Therefore, a significant advantage of an adapter according to the invention is that this device forces the user to remove the nasal tip from the syringe, something very few users currently do. This ensures mandatory safety during the withdrawal process.

[0050] Potential industrial applications or fields of application for such an innovation include: pharmaceuticals and healthcare, hygiene, the pharmaceutical industry, pharmaceutical wholesalers, pharmacies, etc.

[0051] It should also be noted that the invention is not limited to the embodiments described above. Indeed, it will become apparent to those skilled in the art that various modifications can be made to the embodiments described above, in light of the instruction just provided. In the detailed presentation of the invention given above, the terms used should not be interpreted as limiting the invention to the embodiments set forth in this description, but should be interpreted to include all equivalents that a person skilled in the art can foresee by applying their general knowledge to the implementation of the instruction just provided.

Claims

Adapter (10; 40) for container (60) for syringe (72), comprising: a main body (12; 42), having a lateral conformation suitable for forcing into a container opening while being adapted to the complementary shape of an inner lateral wall of this container opening; and a through hole (22), formed longitudinally in the main body (12; 42), for the insertion of a sampling tip (76) of the syringe (72); characterized in that it comprises a cap with a head (24), integral with the main body (12; 42), having an insertion pin (26; 52) conformed to forcing into the through hole (22) and hermetically sealing it. Adapter (10; 40) of container (60) for syringe (72) according to claim 1, in which the head of the cap with head (24) is configured as a circular disc (30) forming a valve, in the center of which extends the insertion pin (26; 52) in a direction essentially normal to this circular disc (30). Adapter (10; 40) of container (60) for syringe (72) according to claim 1 or 2, in which the cap with head (24), in particular the head of the cap with head (24), and the main body (12; 42) are connected to each other by a flexible tab (32), the whole being formed of the same elastic material by molding. Adapter (10; 40) of container (60) for syringe (72) according to any one of claims 1 to 3, wherein the lateral conformation of the main body (12; 42) has a general cylindrical shape for press-fit insertion into a corresponding cylindrical neck (66) of the container opening (60), for example by means of at least one press-fit collar (14, 16; 44). Adapter (10) for container (60) for syringe (72) according to claim 4, wherein: the main body (12) has an outside diameter, excluding neck(s), adapted to the inside diameter of a bottle neck, for example between 22.2 mm and 23 mm, preferably equal to 22.6 mm + / - 0.1 mm for a conventional physiological saline bottle; and the through hole (22) has a diameter adapted to that of a syringe sampling tip, for example between 3.9 mm and 4 mm, preferably equal to 3.95 mm + / - 0.03 mm for a conventional ten millilitre nasal syringe. Adapter (10; 40) of container (60) for syringe (72) according to any one of claims 1 to 5, in which the main body (12; 42) has a curved face (20), in particular with a concave, linear or convex slope, intended to be oriented towards the outside of the container opening (60), in the bottom of which is drilled the through hole (22), this curved face (20) being configured to receive as a stop the head of the cap with head (24) when the insertion pin (26; 52) extends into the through hole (22). Double stopper (62) with adapter (10; 40) of container (60) for syringe (72), intended to seal an opening of the container (60), comprising: an adapter (10; 40) of container (60) for syringe (72) according to any one of claims 1 to 6, forming a first inner stopper (64) of this double stopper (62); and a second outer stopper (68) intended to cooperate with an outer side wall of the opening to seal it while covering the first inner stopper (64). Double adapter cap (10; 40) of container (60) for syringe (72) according to claim 7, wherein the second outer cap (68) has an internal thread cooperating with an external thread (70) of the opening of the container (60). Container (60), containing or intended to contain a fluid to be withdrawn by syringe (72), having an opening (66) and an adapter (10; 40) according to any one of claims 1 to 6, or a double stopper (62) with adapter (10; 40) according to claim 7 or 8. A method for withdrawing fluid from a container (60) according to claim 9, using a syringe (72), comprising the following steps: unscrewing (102), if applicable, the second outer cap (68) to release the opening (66) of the container (60); removing the insertion pin (26; 52) from the first inner cap (64) to release the through hole (22) of the adapter (10; 40); and removing, if applicable, a detachable tip (74) from the syringe (72) to release its sampling tip (76); forcing (104) the sampling tip (76) of the syringe (72) into the through hole (22) of the adapter (10; 40) from above; inverting (106) the container (60) and the syringe (72) inserted in the adapter (10; 40), and then aspirating of a desired quantity of fluid using the syringe (72) from below;inverting (108) the container (60) and the syringe (72) filled with the desired quantity of fluid, then removing the syringe (72) from the top; forcibly inserting (110) the insertion pin (26; 52) of the first inner cap (64) into the through hole (22) of the adapter (10; 40), screwing on, if necessary, the second outer cap (68) to close the opening (66) of the container (60) and, if necessary, placing the detachable tip (74) of the syringe (72) onto its sampling tip (76).

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