Equipment for medical material processing

Abstract

The present application relates to the field of medical material production, and specifically discloses a high pressure equipment for medical material processing, which includes a pressure chamber for placing medical materials and / or raw materials for producing medical materials, and at least one through-hole is opened in the side wall of the pressure chamber, and the high pressure equipment further includes a sealing module for sealing the through-hole, and a fluid injection module is connected to the pressure chamber. A temperature adjustment module is installed in the pressure chamber. The present application can easily pressurize the pressure chamber, thereby realizing high pressure processing for the medical material. In addition, the temperature adjustment module of the present application can adjust the temperature of the fluid medium in the pressure chamber at any time when the temperature in the pressure chamber is too high or too low, thereby improving the effect of pressure processing for the medical material.

Description

[Technical Field]

[0001] This application relates to the field of medical material manufacturing, and in particular to high pressure equipment for medical material processing. [Background technology]

[0002] Medical materials include biomedical materials, which are generally natural or artificially synthesized special functional materials that are used to come into contact with and interact with living systems and can diagnose, treat, replace, repair, or guide regeneration of cells, tissues, and organs.

[0003] High-pressure treatment is one of the methods used in the production or processing of medical materials. High-pressure treatment is used to sterilize medical materials, but in the production of some medical materials, such as decellularized tissue, high pressure can also be used to remove cells from the raw material used to produce the decellularized tissue, i.e., biological tissue.

[0004] Medical materials are one of the most important materials in the medical field, and their production and use have received widespread attention and cherished. High-pressure processing is an important operation method in the production or processing of medical materials. Therefore, it is very important to design high-pressure equipment that can perform good high-pressure processing on medical materials or the raw materials used to produce medical materials. Summary of the Invention [Problem to be solved by the invention]

[0005] In order to perform good high-pressure treatment on medical materials or raw materials for manufacturing medical materials, the present application provides high-pressure equipment for treating medical materials. [Means for solving the problem]

[0006] The high pressure equipment for medical material processing provided in this application adopts the following technical solutions: A high-pressure device for processing medical materials, comprising a pressure chamber for placing medical materials and / or raw materials for manufacturing medical materials, at least one through groove extending through a side wall of the pressure chamber, the high-pressure device further comprising a sealing module for sealing the through groove, and a fluid injection module connected to the pressure chamber.

[0007] By adopting the above technical solution, after the pressure chamber is filled with fluid medium, the volume of the pressure chamber can be maintained as it is, and the fluid injection module can be used to continue injecting fluid medium into the pressure chamber, so that the medical material and / or raw materials for manufacturing medical materials placed in the pressure chamber can be subjected to ultra-high hydrostatic pressure treatment, and sufficient and uniform pressure can be applied to the medical material and / or raw materials for manufacturing medical materials.

[0008] Optionally, the fluid injection module includes a fluid storage tank and an injection pipe, one end of the injection pipe is connected to the pressure chamber, and the other end of the injection pipe is connected to the fluid storage tank by a fluid pump. A first control valve is installed in the injection pipe at a position between the fluid pump and the pressure chamber, and a pressure balance member is further installed in the pressure chamber.

[0009] Optionally, a temperature regulation module is installed in the pressure chamber.

[0010] The adoption of the above technical solution is likely to cause temperature fluctuations of the fluid medium during the process of pressure changes, and temperature generally has a significant impact on the performance of medical materials or raw materials for medical materials. Therefore, the temperature adjustment module adjusts the temperature of the fluid medium when the temperature of the fluid medium rises or falls, so as to ensure that the temperature of the fluid medium is appropriate during the high-pressure treatment process, thereby improving the performance of the final medical material.

[0011] Optionally, the temperature adjustment module includes a fluid adjustment tank for storing a cold fluid or a hot fluid, a communication pipe connected to the fluid adjustment tank, the communication pipe communicating with the fluid storage tank through a power pump, and a first temperature detector installed in the pressure chamber.

[0012] By adopting the above technical solution, after the first temperature detector detects the abnormal temperature of the fluid medium in the pressure chamber, the automatic control system can control the operation of the power pump, and the fluid medium in the fluid adjustment tank enters the fluid storage tank, thereby mixing the two fluid media to neutralize the temperature, and adding the fluid medium with the appropriate temperature to the pressure chamber to adjust the temperature of the fluid medium in the pressure chamber, which is convenient and fast.

[0013] Optionally, a second temperature detector is located within the fluid storage tank.

[0014]

[0013] By adopting the above technical solution, the second temperature detector can detect the temperature of the fluid medium in the fluid storage tank in real time and control the amount of fluid medium added to the fluid storage tank, thereby more accurately controlling the temperature of the fluid medium in the fluid storage tank and facilitating the control of the temperature of the fluid medium entering the pressure chamber. Meanwhile, based on the above test, the temperature fluctuation situation of the fluid medium in the pressure chamber is calculated during the pressurization process corresponding to the pressurization conditions, and then the temperature of the fluid in the fluid storage tank is directly controlled, so that the temperature of the fluid medium in the fluid storage tank is used to offset the temperature change difference value of the pressure chamber during the pressurization process, which is convenient and fast.

[0015] Optionally, the temperature control module includes a neutralization tube, the neutralization tube is connected to the pressure chamber, a fourth control valve is installed on a tube wall of the neutralization tube protruding from the pressure chamber, and a third temperature detector is installed in the pressure chamber.

[0016] By adopting the above technical solution, the third temperature detector detects the temperature inside the pressure chamber. If the temperature inside the pressure chamber is abnormal, the neutralization pipe is directly used to add fluid medium with an appropriate temperature to neutralize the temperature of the fluid medium inside the pressure chamber.

[0017] Optionally, the sealing module includes a first sealing head, which is inserted into the through groove and abuts against a groove wall of the through groove, and a first driving member is connected to the first sealing head for driving the movement of the first sealing head.

[0018] Optionally, there are two through grooves, and the sealing module includes a second sealing head and an adjusting plug, the second sealing head is inserted into one of the through grooves and abuts against the groove wall of the through groove, a second driving member is connected to the second sealing head for driving the sliding movement of the second sealing head, the adjusting plug enters the pressure chamber through the other through groove, the adjusting plug is slidably connected to the groove wall of the through groove, and the adjusting plug and the groove wall of the through groove are hermetically installed, and a driving module is connected to the adjusting plug for driving the sliding movement of the adjusting plug.

[0019] By adopting the above technical solution, the driving module drives the movement of the adjusting plug, adjusts the distance between the adjusting plug and the second sealing head, and adjusts the volume of the pressure chamber, so that the pressure in the pressure chamber can be increased after the volume in the pressure chamber is reduced, and it is easy to realize pressurization of the pressure chamber.

[0020] Optionally, the driving module includes a driving base, a driving block, and a linking block, the linking block is connected to one end of the adjusting plug protruding from the pressure chamber, a driving chamber is installed in the driving base, a sliding groove is installed in the chamber wall of the driving chamber, the linking block enters the driving chamber through the sliding groove, the linking block is slidably connected to the groove wall of the sliding groove and is sealed between the linking block and the groove wall of the sliding groove, the driving block is installed at one end of the linking block entering the driving chamber, the driving block is slidably connected to the chamber wall of the driving chamber, the driving block divides the driving chamber into a first fluid chamber and a second fluid chamber independent of each other, and a circulation module is connected to the driving base for injecting fluid into the first fluid chamber and extracting fluid from the second fluid chamber or injecting fluid into the second fluid chamber and extracting fluid from the first fluid chamber.

[0021] By adopting the above technical solution, the fluid flows through the first fluid chamber and the second fluid chamber under the action of the circulation module, and thereby the pressure difference between the first fluid chamber and the second fluid chamber is utilized to slide the driving block in a predetermined direction. When the driving block moves toward the pressure chamber, it also moves the adjusting plug toward the second sealing head, which facilitates pressurizing the pressure chamber.

[0022] Optionally, the circulation module includes a first circulation pipe, a second circulation pipe, a third circulation pipe, and a fourth circulation pipe, one ends of the first circulation pipe and the second circulation pipe are all connected to the drive base, the first circulation pipe is in communication with the first fluid chamber, the second circulation pipe is in communication with the first fluid chamber, one end of the first circulation pipe remote from the drive base and one end of the second circulation pipe remote from the drive base are connected to a circulation pump, one end of the third circulation pipe is in communication with a position of the first circulation pipe close to the drive base, The other end of the third circulation pipe is connected to a position of the second circulation pipe close to the circulation pump, one end of the fourth circulation pipe is connected to a position of the second circulation pipe close to the drive base, and the other end of the fourth circulation pipe is connected to a position of the first circulation pipe close to the circulation pump. Second control valves are installed at a position of the first circulation pipe between the third circulation pipe and the fourth circulation pipe, a position of the third circulation pipe close to the second circulation pipe, a position of the second circulation pipe between the third circulation pipe and the fourth circulation pipe, and a position of the fourth circulation pipe close to the second circulation pipe.

[0023] By adopting the above technical solution, the first and second valves are closed and the third and fourth valves are opened, so that the fourth circulation pipe, the fluid pump, and the third circulation pipe form a fluid flow path between the first and second fluid chambers. By closing the third and fourth valves and opening the first and second valves, a fluid flow path is formed between the first circulation pipe, the circulation pump, and the second circulation pipe, and when the circulation pump is started, the fluid can flow in the first and second fluid chambers according to the predetermined fluid flow path.

[0024] Optionally, the injection pipe is connected to a discharge pipe at a position between the first control valve and the pressure chamber, and a third control valve is installed in the discharge pipe. [Effects of the Invention]

[0025] As described above, the present application includes at least one of the following beneficial technical effects. 1. After the pressure chamber is sealed, the fluid medium can be continuously injected into the pressure chamber, which can easily pressurize the pressure chamber, thereby realizing hydrostatic pressure treatment for medical materials or raw materials for medical materials.

[0026] 2. In the present invention, after the pressure chamber is sealed, the pressure chamber can be easily pressurized by moving the adjusting plug and reducing the volume of the pressure chamber.

[0027] 3. The present invention is equipped with a temperature adjustment module, which can adjust the temperature of the fluid medium in the pressure chamber as needed when the temperature inside the pressure chamber is too high or too low, thereby improving the pressure treatment effect on medical materials or raw materials for medical materials.

[0028] 4. A second temperature detector is installed in the fluid storage tank of the present application, which can detect the temperature of the fluid medium in the fluid storage tank in real time and work in cooperation with the temperature control module, and can directly control the temperature of the fluid in the fluid storage tank, so that the temperature of the fluid medium in the fluid storage tank can be used to offset the temperature change difference value of the pressure chamber during the pressurization process. [Brief explanation of the drawings]

[0029] [Figure 1] 1 is a structural schematic diagram of a high-pressure device for medical material processing in Example 1 of the present application. [Figure 2] FIG. 2 is a cross-sectional view taken along line AA in FIG. [Figure 3] FIG. 10 is a structural schematic diagram of a high-pressure device for medical material processing in Example 2 of the present application. [Figure 4] FIG. 10 is a structural schematic diagram of a high-pressure device for medical material processing in Example 3 of the present application. [Figure 5] FIG. 5 is a cross-sectional view taken along line BB in FIG. [Figure 6] FIG. 10 is a structural schematic diagram of a high-pressure device for medical material processing in Example 4 of the present application. [Figure 7] FIG. 7 is a cross-sectional view taken along line CC in FIG. 6. [Figure 8]FIG. 10 is a structural schematic diagram of a high-pressure device for medical material processing in Example 5 of the present application. [Figure 9] FIG. 9 is a cross-sectional view taken along line DD in FIG. 8. DETAILED DESCRIPTION OF THE INVENTION

[0030] The present application will now be described in more detail with reference to the drawings.

[0031] Decellularized tissues are widely used as biomedical materials in the field of tissue transplantation due to their low immune rejection. Decellularization is a process for obtaining decellularized tissues, which involves removing cells from foreign or xenogeneic tissues using chemical and physical methods, thereby producing and molding non-immunogenic or low-immunogenic biological tissue structures.

[0032] This embodiment takes the example of obtaining a decellularized tissue biological medical material, and uses the high-pressure equipment for processing medical materials of the present application to perform hydrostatic pressure treatment on the biological tissue, remove cells from the biological tissue, and disinfect and sterilize the biological tissue to obtain a decellularized tissue, in which the fluid medium may be saline or the like. [Example 1]

[0033] Example 1 provides a high-pressure device for medical material processing.

[0034] 1 and 2, a high-pressure device for medical material processing includes a pressure chamber 1 and a base 2. In this embodiment, the pressure chamber 1 is cylindrical, with a through-hole 11 drilled through the side wall at one axial end of the pressure chamber 1 and a sealed installation at the other axial end of the pressure chamber 1. The pressure chamber 1 is fixedly connected to a base 2, a sealing module 3 is attached to the base 2, and a fluid injection module 4 is connected to the pressure chamber 1. The sealing module 3 is operated to open the through-hole 11, biological tissue is placed in the pressure chamber 1, the sealing module 3 is operated to seal the through-hole 11, and then the fluid injection module 4 is operated to fill the pressure chamber 1 with a fluid medium. In this embodiment, the fluid medium is saline. When pressurization is required, the fluid injection module 4 is continuously operated to inject the fluid medium into the pressure chamber 1. During this process, the volume within the pressure chamber 1 remains unchanged, so that the pressurization operation can be achieved.

[0035] As shown in Figures 1 and 2, the sealing module 3 includes a first sealing head 31, and a first driving member 32 is fixedly connected to the base 2. The first driving member 32 in this embodiment can drive a cylinder, a hydraulic cylinder, etc. The first driving module 7 in this embodiment is a driving cylinder. The driving end of the first driving member 32 faces the through groove 11 along the axial direction of the pressure chamber 1. The first sealing head 31 includes a first sealing plate 33 fixedly connected to the driving end of the first driving member 32 and a first sealing plug 34 fixedly connected to one side wall of the first sealing plate 33 away from the first driving member 32. The first sealing plug 34 is inserted into the through groove 11 and abuts against the groove wall of the through groove 11. A first sealing sheet 35 is fixedly connected to the side wall of the first sealing plate 33 facing the pressure chamber 1, and the first sealing sheet 35 abuts against the end wall of the pressure chamber 1. By activating the first driving member 32 and moving the first sealing plate 33 and the first sealing plug 34 away from the pressure chamber 1, the through groove 11 can be opened, and by activating the first driving member 32 and inserting the first sealing plug 34 into the through groove 11 and abutting the end walls of the first sealing plate 33 and the pressure chamber 1, the pressure chamber 1 can be sealed.

[0036] 1 and 2, the fluid injection module 4 in this embodiment includes a fluid storage tank 41 and an injection pipe 42. One end of the injection pipe 42 is fixedly connected to the first sealing head 31. The injection pipe 42 passes through a first sealing plate 33 and a first sealing plug 34 before entering the pressure chamber 1. The first sealing plate 33 and the first sealing plug 34 are both hermetically connected to the outer wall of the injection pipe 42. The other end of the injection pipe 42 is connected to a fluid pump 43. An end of the fluid pump 43 remote from the injection pipe 42 is connected to a rise pipe 44. The end of the rise pipe 44 remote from the fluid pump 43 enters the fluid storage tank 41. A first control valve 45 is attached to the injection pipe 42 between the fluid pump 43 and the first sealing plate 33. A discharge pipe 46 is connected to the injection pipe 42 between the first control valve 45 and the first sealing plate 33, and a third control valve 47 is attached to the discharge pipe 46. Moreover, in this embodiment, a pressure balance member 5 is further attached to the first sealing head 31, and the pressure balance member 5 includes a balance pipe 51 fixedly connected to the first sealing head 31. The balance pipe 51 passes through a first sealing plate 33 and a first sealing plug 34 before entering the pressure chamber 1. The first sealing plate 33 and the first sealing plug 34 are both hermetically connected to the outer wall of the balance pipe 51, and a pressure balance valve 52 is attached to the wall of the balance pipe 51 protruding from the first sealing head 31. In this embodiment, a pressure detector 48 is attached to the first sealing plug 34.

[0037] The operating principle of the high-pressure medical material processing device in Example 1 is as follows: biological tissue is placed in pressure chamber 1, and first drive member 32 is activated to insert first sealing head 31 into through-groove 11. First sealing head 31 and first sealing plate 33 seal through-groove 11 of pressure chamber 1. The pressure balance valve 52 is opened, and fluid pump 43 is activated to fill pressure chamber 1 with the fluid medium from fluid storage tank 41. Then, pressure balance valve 52 is closed. Pressure continues to be applied to pressure chamber 1 as needed. Since the volume of pressure chamber 1 remains constant, the pressure in pressure chamber 1 increases. The biological tissue can be decellularized until the pressure detector 48 detects that the pressure in pressure chamber 1 reaches the required level. After the high-pressure processing is completed, the pressure is released, and then the third control valve 47 is opened to discharge the fluid medium from pressure chamber 1. Finally, the first drive member 32 is activated to move first sealing head 31 away from pressure chamber 1, and the processed biological tissue can be removed. [Example 2]

[0038] As shown in FIG. 3 , the second embodiment of the high-pressure equipment for medical material processing differs from the first embodiment in the following ways: A second temperature detector 62 is fixedly installed inside the fluid storage tank 41. Before performing full-scale high-pressure processing, a simulated pressurization operation is performed under predetermined pressurization conditions to obtain temperature changes of the fluid medium in the pressure chamber 1 throughout the pressurization process. Based on these changes, the temperature range of the fluid medium required for the fluid storage tank 41 is estimated. During full-scale pressurization, the second temperature detector 62 detects the temperature of the fluid medium in the fluid storage tank 41 in real time. If an abnormality occurs in the temperature of the fluid medium in the fluid storage tank 41, the temperature of the fluid medium in the fluid storage tank 41 can be directly adjusted. The temperature of the fluid medium in the fluid storage tank 41 can be adjusted by adding a fluid medium of an appropriate temperature to neutralize it, or by using a cooler, heating pipe, or other device. [Example 3]

[0039] 4 and 5, the third embodiment of the high-pressure equipment for medical material processing differs from the second embodiment in the following respects. A temperature adjustment module 6 is attached to the pressure chamber 1 of this embodiment. The temperature adjustment module 6 includes a fluid adjustment tank 61, which contains a cold fluid or a hot fluid. In this embodiment, the fluid adjustment tank 61 contains a cold fluid, and the cold fluid and the fluid medium in the fluid storage tank 41 are the same substance. A communication pipe 63 is connected to the fluid adjustment tank 61, and the communication pipe 63 communicates with the fluid storage tank 41 via a power pump 64. A first temperature detector 65 is fixedly attached to the side wall of the first sealing plug 34 that enters the pressure chamber 1.

[0040] The operating principle of the high-pressure equipment for medical material processing in Example 3 is as follows: The first temperature detector 65 detects the temperature of the fluid medium in the pressure chamber 1. If the temperature in the pressure chamber 1 is found to be too high, the automatic control system turns on the power pump 64, and the cold fluid in the fluid adjustment tank 61 is injected into the fluid storage tank 41 for neutralization. At the same time, the second temperature detector 62 detects the temperature of the fluid storage tank 41 in real time. If the temperature of the fluid medium in the fluid storage tank 41 is appropriate, the automatic control system starts the fluid pump 43 to add a relatively low-temperature fluid medium to the pressure chamber 1 until the temperature in the pressure chamber 1 reaches an appropriate range. Alternatively, while adding a relatively low-temperature fluid medium to the pressure chamber 1, the third control valve 47 is simultaneously opened to discharge the relatively high-temperature fluid medium from the pressure chamber 1, thereby more quickly adjusting the temperature of the fluid medium in the pressure chamber 1, provided that the operating safety of the pressure chamber 1 is ensured. [Example 4]

[0041] 6 and 7, the fourth embodiment of the high-pressure equipment for medical material processing differs from the first embodiment in the following respects: In this embodiment, a temperature control module 6 is attached to the pressure chamber 1, and the temperature control module 6 includes a neutralization tube 311 attached to the first sealing head 31. The neutralization tube 311 passes through a first sealing plate 33 and a first sealing plug 34 before entering the pressure chamber 1, and the first sealing plate 33 and the first sealing plug 34 are both hermetically connected to the outer wall of the neutralization tube 311. A fourth control valve 312 is attached to the wall of the neutralization tube 311 protruding from the pressure chamber 1. In this embodiment, a third temperature detector 313 is attached to the side of the first sealing plug 34 away from the first sealing plate 33. The third temperature detector 313 detects the temperature in the pressure chamber 1 in real time. If the temperature in the pressure chamber 1 is too high or too low, the fourth control valve 312 is opened to inject a fluid medium into the pressure chamber 1 through the neutralization pipe 311 to neutralize the temperature in the pressure chamber 1. Then, the pressure chamber 1 continues to be pressurized normally until the temperature in the pressure chamber 1 becomes appropriate. [Example 5]

[0042] As shown in Figures 8 and 9, the fifth embodiment of the high-pressure equipment for medical material processing differs from the third embodiment in the following respects. In this embodiment, one through-hole 11 penetrates each of the axial end side walls of the pressure chamber 1. For ease of explanation, one through-hole 11 is named the material through-hole 12, and the other through-hole 11 is named the adjustment groove 13. The sealing module 3 includes a second sealing head 36 and an adjustment plug 37. A second driving member 38 is attached to the base 2 at a position facing the material through-hole 12. The second driving member 38 may be a driving cylinder, a hydraulic cylinder, or the like. In this embodiment, the second driving member 38 is a driving cylinder. The second sealing head 36 in this embodiment includes a second sealing plate 361 fixedly connected to the driving end of the second driving member 38 and a second sealing plug 362 fixedly connected to one side wall of the second sealing plate 361 facing the pressure chamber 1. The second sealing plug 362 is inserted into the material through-hole 12 and abuts against the groove wall of the material through-hole 12. A second gasket 39 is fixedly connected to one side of the second sealing plate 361 facing the pressure chamber 1, and the second sealing plate 361 abuts against the end wall of the pressure chamber 1. Moreover, the balance pipe 51 and the injection pipe 42 are both attached to the second sealing head 36, and the first temperature detector 65 and the pressure detector 48 are both attached to one side wall of the second sealing plug 362 facing away from the second sealing plate 361.

[0043] 8 and 9, the adjusting plug 37 enters the pressure chamber 1 through the adjusting groove 13, and the adjusting plug 37 slides and connects with the groove wall of the adjusting groove 13, and the adjusting plug 37 is installed so as to seal the gap between the adjusting plug 37 and the groove wall of the through groove 11. A driving module 7 that drives the sliding movement of the adjusting plug 37 is attached to the base 2.

[0044] 8 and 9, the driving module 7 in this embodiment includes a driving base 71, a driving block 72, and an interlocking block 73. The driving base 71 is fixedly connected to the base 2 and faces the adjustment groove 13. A driving chamber 74 is installed within the driving base 71. A sliding groove 75 is installed in the chamber wall near the driving chamber 74 and facing the material through-hole groove 12. The interlocking block 73 is fixedly connected to one end of the adjustment plug 37 protruding from the pressure chamber 1. The interlocking block 73 enters the driving chamber 74 through the sliding groove 75. The interlocking block 73 and the groove wall of the sliding groove 75 slide to connect with each other, and the space between the interlocking block 73 and the groove wall of the sliding groove 75 is sealed. The drive block 72 is fixedly connected to one end of the interlocking block 73 that enters the drive chamber 74, and the peripheral wall of the drive block 72 is slidably connected to and sealed with the chamber wall of the drive chamber 74. The drive block 72 divides the drive chamber 74 into a first fluid chamber 76 and a second fluid chamber 77 that are independent of each other, and the first fluid chamber 76 is located on one side of the second fluid chamber 77 that is away from the pressure chamber 1. Furthermore, a pressure detector 78 is fixedly attached to the chamber wall of both the first fluid chamber 76 and the second fluid chamber 77, and an adjustment pipe 79 is connected to the chamber wall of both the first fluid chamber 76 and the second fluid chamber 77, and a pressure adjustment valve 791 is attached to the pipe wall where the adjustment pipe 79 protrudes from the drive base 71.

[0045] As shown in Figures 8 and 9, a circulation module 8 is attached to the drive base 71, and the circulation module 8 includes a first circulation pipe 81, a second circulation pipe 82, a third circulation pipe 83, and a fourth circulation pipe 84, one ends of the first circulation pipe 81 and the second circulation pipe 82 are all connected to the drive base 71, the first circulation pipe 81 is connected to the first fluid chamber 76, the second circulation pipe 82 is connected to the first fluid chamber 76, a circulation pump 85 is connected to one end of the first circulation pipe 81 away from the drive base 71, and one end of the circulation pump 85 away from the first circulation pipe 81 is connected to one end of the second circulation pipe 82 away from the drive base 71.

[0046] 8 and 9 , one end of the third circulation pipe 83 communicates with the first circulation pipe 81 at a position close to the drive base 71, and one end of the third circulation pipe 83 remote from the first circulation pipe 81 communicates with the second circulation pipe 82 at a position close to the circulation pump 85. One end of the fourth circulation pipe 84 communicates with the second circulation pipe 82 at a position close to the drive base 71, and one end of the fourth circulation pipe 84 remote from the second circulation pipe 82 communicates with the first circulation pipe 81 at a position close to the circulation pump 85. Second control valves 86 are installed at a position of the first circulation pipe 81 between the third circulation pipe 83 and the fourth circulation pipe 84, a position of the third circulation pipe 83 close to the second circulation pipe 82, a position of the second circulation pipe 82 between the third circulation pipe 83 and the fourth circulation pipe 84, and a position of the fourth circulation pipe 84 close to the second circulation pipe 82. For ease of explanation, the second control valve 86 in the first circulation pipe 81 will be named the first valve 861, the second control valve 86 in the second circulation pipe 82 will be named the second valve 862, the second control valve 86 in the third circulation pipe 83 will be named the third valve 863, and the second control valve 86 in the fourth circulation pipe 84 will be named the fourth valve 864.

[0047] The high-pressure equipment for medical material processing in Example 5 of the present application includes two pressurization methods, one of which is to apply pressure by continuously adding fluid medium to the pressure chamber 1 while maintaining the position of the adjustment plug 37.

[0048] Another pressurizing device does not continuously inject fluid medium into pressure chamber 1, but instead closes first valve 861 and second valve 862, opens third valve 863 and fourth valve 864, and turns on circulation pump 85. The liquid in second fluid chamber 77 flows through fourth circulation pipe 84, fluid pump 43, and third circulation pipe 83 into first fluid chamber 76, moving drive block 72 toward pressure chamber 1. The interlocking block 73 then moves regulating plug 37 toward second sealing plug 362, reducing the volume of pressure chamber 1 and achieving pressurization. When pressure relief is required, closes third valve 863 and fourth valve 864, starts circulation pump 85, and opens first valve 861 and second valve 862. The liquid in first fluid chamber 76 flows through first circulation pipe 81, circulation pump 85, and second circulation pipe 82 into second fluid chamber 77, and the drive block 72 moves regulating plug 37 away from second sealing plug 362.

[0049] In addition, to increase safety during pressurization, the pressure detector 78 detects the pressure in the first fluid chamber 76 and the second fluid chamber 77 in real time, and if the pressure is abnormal, the pressure can be adjusted by the pressure adjustment valve 791.

[0050] The above are preferred embodiments of the present application, and the scope of protection of the present application is not limited based on these. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application. [Explanation of symbols]

[0051] 1...pressure chamber, 11...through groove, 12...material through groove, 13...adjusting groove, 2...base, 3...sealing module, 31...first sealing head, 311...neutralization pipe, 312...fourth control valve, 313...third temperature detector, 32...first driving member, 33...first sealing plate, 34...first sealing plug, 35...first sealing seat, 36...second sealing head, 361...second sealing plate, 362...second sealing plug, 37...adjusting plug, 38...second driving member, 39...second gasket, 4...fluid injection module, 41...fluid storage tank, 42...injection pipe, 43...fluid pump, 44...lift pipe, 45...first control valve, 46...discharge pipe, 47...third control valve, 48...pressure detector, 5...pressure balance member, 51. ..Balance pipe, 52...pressure balance valve, 6...temperature adjustment module, 61...fluid adjustment tank, 62...second temperature detector, 63...communicating pipe, 64...power pump, 65...first temperature detector, 7...drive module, 71...drive base, 72...drive block, 73...interlocking block, 74...drive chamber, 75...slide movement groove, 76...first fluid chamber, 77...second fluid chamber, 78...pressure detector, 79...adjustment pipe, 791...pressure adjustment valve, 8...circulation module, 81...first circulation pipe, 82...second circulation pipe, 83...third circulation pipe, 84...fourth circulation pipe, 85...circulation pump, 86...second control valve, 861...first valve, 862...second valve, 863...third valve, 864...fourth valve.

Claims

1. An apparatus for processing medical materials, comprising a pressure chamber (1) for placing medical materials and / or raw materials for manufacturing medical materials, the pressure chamber (1) having at least one through-groove (11) extending through a side wall thereof, the apparatus further comprising a sealing module (3) for sealing the through-groove (11), and a fluid injection module (4) connected to the pressure chamber (1); There are two through grooves (11), and the sealing module (3) includes a second sealing head (36) and an adjusting plug (37), the second sealing head (36) is inserted into one of the through grooves (11) and abuts against the groove wall of the through groove (11), a second driving member (38) is connected to the second sealing head (36) for driving the sliding movement of the second sealing head (36), the adjusting plug (37) enters the pressure chamber (1) through the other through groove (11), the adjusting plug (37) is slidably connected to the groove wall of the through groove (11), and the adjusting plug (37) and the groove wall of the through groove (11) are hermetically installed between them, and a driving module (7) is connected to the adjusting plug (37) for driving the sliding movement of the adjusting plug (37). The driving module (7) includes a driving base (71), a driving block (72) and an interlocking block (73), the interlocking block (73) is connected to one end of the adjusting plug (37) protruding from the pressure chamber (1), a driving chamber (74) is installed in the driving base (71), a sliding groove (75) is installed in the chamber wall of the driving chamber (74) and the interlocking block (73) enters the driving chamber (74) through the sliding groove (75), the interlocking block (73) slides and connects with the groove wall of the sliding groove (75), and the space between the interlocking block (73) and the groove wall of the sliding groove (75) is sealed, and a drive block (72) installed at one end of the interlocking block (73) entering the drive chamber (74), the drive block (72) slidingly connected to a chamber wall of the drive chamber (74), the drive block (72) dividing the drive chamber (74) into a first fluid chamber (76) and a second fluid chamber (77) independent of each other, and a circulation module (8) connected to the drive base (71) for injecting fluid into the first fluid chamber (76) and extracting fluid from the second fluid chamber (77) or for injecting fluid into the second fluid chamber (77) and extracting fluid from the first fluid chamber (76).

2. 2. The medical material processing device according to claim 1, wherein the fluid injection module (4) comprises a fluid storage tank (41) and an injection pipe (42), one end of the injection pipe (42) being connected to the pressure chamber (1) and the other end of the injection pipe (42) being connected to the fluid storage tank (41) by a fluid pump (43), a first control valve (45) being installed on the injection pipe (42) at a position between the fluid pump (43) and the pressure chamber (1), and a pressure balance member (5) being further installed in the pressure chamber (1).

3. 3. The medical material processing device according to claim 2, wherein a second temperature detector (62) is installed in the fluid storage tank (41).

4. 2. The medical material processing device according to claim 1, characterized in that a temperature control module (6) is installed in the pressure chamber (1).

5. 5. The medical material processing device according to claim 4, wherein the temperature adjustment module (6) includes a fluid adjustment tank (61) for storing a cold fluid or a hot fluid, a connecting pipe (63) connected to the fluid adjustment tank (61), the connecting pipe (63) being connected to the fluid injection module (4) by a power pump (64), and a first temperature detector (65) being installed in the pressure chamber (1).

6. The medical material processing device according to claim 4, characterized in that the temperature control module (6) includes a neutralization pipe (311), the neutralization pipe (311) is connected to the pressure chamber (1), a fourth control valve (312) is installed on the pipe wall of the neutralization pipe (311) protruding from the pressure chamber (1), and a third temperature detector (313) is installed in the pressure chamber (1).

7. The medical material processing device according to claim 1, characterized in that the sealing module (3) includes a first sealing head (31), which is inserted into the through groove (11) and abuts against the groove wall of the through groove (11), and a first driving member (32) is connected to the first sealing head (31) for driving the movement of the first sealing head (31).

8. The circulation module (8) includes a first circulation pipe (81), a second circulation pipe (82), a third circulation pipe (83), and a fourth circulation pipe (84), one end of each of the first circulation pipe (81) and the second circulation pipe (82) is connected to the drive base (71), the first circulation pipe (81) is connected to the first fluid chamber (76), the second circulation pipe (82) is connected to the first fluid chamber (76), one end of the first circulation pipe (81) remote from the drive base (71) and one end of the second circulation pipe (82) remote from the drive base (71) are connected by a circulation pump (85), one end of the third circulation pipe (83) is connected to a position of the first circulation pipe (81) close to the drive base (71), and the other end of the third circulation pipe (83) is connected to the second circulation pipe (76).

2. The medical material processing device according to claim 1, wherein one end of the fourth circulation pipe (84) is connected to the second circulation pipe (82) at a position close to the circulation pump (85), one end of the fourth circulation pipe (84) is connected to the second circulation pipe (82) at a position close to the drive base (71), and the other end of the fourth circulation pipe (84) is connected to the first circulation pipe (81) at a position close to the circulation pump (85), and second control valves (86) are installed at a position on the first circulation pipe (81) between the third circulation pipe (83) and the fourth circulation pipe (84), a position on the third circulation pipe (83) close to the second circulation pipe (82), a position on the second circulation pipe (82) between the third circulation pipe (83) and the fourth circulation pipe (84), and a position on the fourth circulation pipe (84) close to the second circulation pipe (82).

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