Auto Injector Assembly

Abstract

The automatic injector assembly (100) includes a housing (102), a syringe assembly (202) that stores a predetermined amount of a drug to be administered, a needle guard (212) that surrounds the syringe assembly (202), a portion of the needle guard (212) initially extending outside the housing (102) and adapted to retract into the housing (102) when the portion is pressed against an injection site, a spring holder (218) for holding a dose delivery spring (216), a locking unit (220) for keeping the spring holder (218) locked in a compressed state, and a plunger (222) that engages with the spring holder (218) and is adapted to move toward the syringe assembly (202) when the spring holder (218) is unlocked. The engagement position of plunger (222) and spring holder (218) is adapted to vary to control the distance traveled by plunger (222) within housing (102) based on a predetermined amount of medication in syringe assembly (202).

Description

[Technical Field]

[0001] The present disclosure relates to automatic injectors, and more particularly to automatic injector assemblies having plungers and adapted to operate to deliver different amounts of medication into an injection site. [Background technology]

[0002] Auto injectors are widely used to deliver drugs directly into a patient's body. Currently, there are many auto injectors available on the market. Existing auto injectors are primarily capable of delivering a predetermined dose of a drug to a patient. Typically, conventional auto injectors are adapted to deliver a predetermined dose of a drug to a patient. As is commonly known, each drug needs to be delivered to a patient in a different amount. This may also vary from patient to patient depending on the patient's condition, age, etc. Similarly, there are multiple other factors that contribute to determining the dosage of a drug to be injected into a patient's body. Therefore, for effective treatment, the same drug may need to be delivered in different amounts to different patients. However, manufacturers must produce specific autoinjectors for predefined amounts of the drug to be administered.

[0003] Therefore, to deliver a specific amount of drug, it is necessary to build a specific auto-injector that can deliver the predetermined dose to the patient. Due to such structural limitations, multiple auto-injectors are required for different dose volumes. Therefore, it is inconvenient for consumers to purchase, operate, and maintain multiple auto-injectors. Meanwhile, pharmaceutical manufacturers also need to manufacture multiple auto-injectors for various drugs that require different dose settings. For example, manufacturers may have to make significant efforts and investments in manufacturing plant infrastructure. Some device manufacturers are modifying auto-injector components to allow for variable dose delivery, but producing such auto-injectors requires significant modifications to the manufacturing plant's assembly line, which also increases the overall operating costs of the auto-injector. Summary of the Invention

[0004] This Summary is provided to introduce a selection of concepts in a simplified form that are further described in the Detailed Description. This Summary is not intended to identify key or essential inventive concepts of the invention, nor is it intended to delineate the scope of the invention. In one embodiment of the present disclosure, an automatic injector assembly is disclosed. The automatic injector assembly includes a housing having a proximal end and a distal end, a syringe assembly disposed adjacent to the proximal end of the housing and adapted to store a predetermined amount of a medication to be administered through a needle, a needle guard disposed surrounding the syringe assembly, a portion of the needle guard initially extending out of the housing and adapted to retract into the housing when pressed against an injection site, a spring holder disposed adjacent to the distal end of the housing and adapted to hold a dose delivery spring in a compressed state, a locking unit disposed inside the spring holder and adapted to maintain the spring holder locked with the housing, and a plunger adapted to engage with the spring holder and move toward the syringe assembly when the spring holder is unlocked. The engagement position of the plunger with the spring holder is adapted to change to control the distance the plunger travels within the housing based on the predetermined amount of medication in the syringe assembly. When the needle guard is retracted, it is adapted to push the locking unit further into the spring holder, unlocking the spring holder from the housing (102) and allowing the plunger to be moved towards the syringe assembly for administration of the medication into the injection site.

[0005] To further clarify the advantages and features of the present invention, a more particular description of the invention will be rendered by reference to specific embodiments thereof which are illustrated in the accompanying drawings. It is understood that these drawings depict only typical embodiments of the invention and therefore should not be considered as limiting its scope. The invention will be described and explained with additional specificity and detail through the use of the accompanying drawings. [Brief explanation of the drawings]

[0006] These and other features, aspects, and advantages of the present invention will be better understood when the following detailed description is read in conjunction with the accompanying drawings, in which like characters represent like parts throughout the drawings: [Figure 1] FIG. 1 shows a perspective view of an automatic injector assembly according to one embodiment of the present disclosure; [Figure 2] FIG. 2 shows an exploded view of an automatic injector assembly showing various components according to one embodiment of the present disclosure; [Figure 3] FIG. 3 shows another exploded view of an automatic injector assembly according to one embodiment of the present disclosure; [Figure 4] FIG. 4 shows a cross-sectional view of an automatic injector assembly showing various components according to one embodiment of the present disclosure; [Figure 5] FIG. 5 illustrates a cross-sectional view of a portion of an automatic injector assembly showing the locking of the spring holder with the housing according to one embodiment of the present disclosure; [Figure 6] FIG. 6 illustrates a cross-sectional view of an automatic injector assembly showing the unlocking of the spring holder by movement of the needle guard according to one embodiment of the present disclosure. [Figure 7A] FIG. 7A shows a cross-sectional view of an automatic injector assembly showing the positions of components in an initial state, according to one embodiment of the present disclosure; [Figure 7B] FIG. 7B shows a cross-sectional view of the automatic injector assembly showing the position of the components after the drug has been administered, according to one embodiment of the present disclosure; [Figure 8A] FIG. 8A illustrates the positioning of the needle guard relative to the syringe holder in an initial state, according to one embodiment of the present disclosure: [Figure 8B] FIG. 8B illustrates the positioning of the needle guard relative to the syringe holder after the medication has been administered, according to one embodiment of the present disclosure; and [Figure 9] FIG. 9 illustrates an example showing how a user may use an automatic injector assembly, according to one embodiment of the present disclosure.

[0007] Additionally, those skilled in the art will appreciate that elements in the figures are illustrated for simplicity and may not necessarily be drawn to scale. For example, a flowchart may illustrate a method in terms of the most prominent steps involved to aid in a better understanding of aspects of the invention. Furthermore, with respect to device structure, one or more components of the device may be represented in the figures by conventional symbols, and the figures may show only certain details relevant to understanding embodiments of the invention so as not to obscure the figures with details that will be readily apparent to one of ordinary skill in the art having the benefit of the description herein.

[0008] Detailed Description of the Drawings For the purposes of promoting an understanding of the principles of the invention, reference will now be made to the embodiments illustrated in the drawings and specific language will be used to describe same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended. Such changes and further modifications in the illustrated systems, and such further applications of the principles of the invention as illustrated therein, as would normally occur to one of ordinary skill in the art to which the invention pertains, are contemplated. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The systems, methods, and examples provided herein are for illustrative purposes only and are not intended to be limiting.

[0009] For example, the term "some" as used herein may be understood as "none," or "one," or "two or more," or "all." Thus, the terms "none," "one," "multiple," "multiple but not all," or "all" fall within the definition of "some." The terms and structures used herein are intended to describe, teach, and clarify some embodiments and their specific features and elements, and therefore should not be construed to limit, restrict, or reduce the spirit and scope of the present disclosure. It should be understood by those skilled in the art.

[0010] Any terms used herein, such as "comprises," "includes," "having," "comprises," and similar grammatical variations, do not specify precise limitations or restrictions unless otherwise expressly stated, and certainly do not exclude the possibility of the addition of one or more features or elements. Furthermore, these terms should not be considered to exclude the possibility of the omission of one or more of the listed features and elements, unless otherwise stated, by use of limiting language, including, but not limited to, for example, "shall include" or "should include." Regardless of whether a particular feature or element has been limited to being used only once, it may still be referred to as "one or more features" or "one or more elements" or "at least one feature" or "at least one element." Furthermore, the use of the term "one or more" or "at least one" feature or element does not exclude the presence of any of those features or elements unless otherwise specified by limiting language, including but not limited to, "there must be one or more..." or "one or more elements are required." Unless otherwise defined, all terms used herein, particularly technical and / or scientific terms, may be construed to have the same meaning as commonly understood by one of ordinary skill in the art.

[0011] Reference is made herein to several "embodiments." It should be understood that embodiments are examples of possible implementations of any feature and / or element in the disclosure. Some embodiments have been described for the purpose of illustrating one or more potential ways in which particular features and / or elements in the disclosure meet the requirements of uniqueness, usefulness, and non-obviousness.

[0012] Use of phrases and / or terms including, but not limited to, "first embodiment," "further embodiment," "alternative embodiment," "one embodiment," "embodiment," "multiple embodiments," "some embodiments," "other embodiments," "further embodiments," "still further embodiments," "additional embodiments," or other variations thereof, does not necessarily refer to the same embodiment. Unless specified otherwise, one or more particular features and / or elements described in connection with one or more embodiments may be found in one embodiment, more than one embodiment, all embodiments, or none of the embodiments. Although one or more features and / or elements may be described herein in the context of only a single embodiment, in the context of multiple embodiments, or in the context of all embodiments, the features and / or elements may instead be provided individually, in any suitable combination, or not at all. Conversely, any features and / or elements that are described in the context of separate embodiments may alternatively be realized as coexisting in the context of a single embodiment.

[0013] All specific details described herein are used in the context of several embodiments and therefore should not necessarily be construed as limitations on the proposed disclosure.

[0014] The present disclosure relates to an automatic injector assembly having a plunger capable of administering different amounts of medication. The position of the plunger can be adjusted to change the distance traveled within the housing based on different amounts of medication to be delivered to a patient. The position needs to be adjusted so that the plunger can travel the distance required to expel the medication from the syringe assembly. The plunger is adapted to engage with a spring holder at different positions based on dosage requirements to vary the distance traveled by the plunger within the housing. This adjustment of the plunger position occurs only during the manufacturing stage, for example, by the manufacturer, in response to a predefined amount of medication to be administered by the particular device. Therefore, the user does not need to adjust the device and can use it directly.

[0015] The automatic injector assembly may also include one or more stoppers on the interior surface of the housing for engaging the spring holder to limit movement of the plunger to administer the medication unless the user manually activates the device, and the plunger is adapted to move and force the medication into the injection site only when manual activation by the user releases the spring holder from the stopper.

[0016] For clarity, the first digit of the reference number for each component in this disclosure indicates the number of the figure in which the corresponding component is shown. For example, a reference number beginning with the digit "1" appears in at least FIG. 1. Similarly, a reference number beginning with the digit "2" appears in at least FIG. 2.

[0017] Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. FIG. 1 shows a perspective view of an automatic injector assembly 100 according to one embodiment of the present disclosure. FIG. 2 shows an exploded view of the automatic injector assembly 100 showing various components according to one embodiment of the present disclosure. FIG. 3 shows another exploded view of the automatic injector assembly 100 according to one embodiment of the present disclosure. FIG. 4 shows a cross-sectional view of the automatic injector assembly 100 showing various components according to one embodiment of the present disclosure. With reference to FIGS. 1, 2, 3, and 4, the automatic injector assembly 100 may include, but is not limited to, a housing 102, a syringe assembly 202 having a needle 406, a needle shield 408, a cap 208, a syringe holder 210, a needle guard 212, a needle guard spring 214, a dose delivery spring 216, a spring holder 218, a locking unit 220, and a plunger 222.

[0018] In one embodiment, the housing 102 can include a proximal portion 108 and a distal portion 110. The proximal portion 108 can accommodate the positioning of the syringe assembly 202, the needle shield 408, the cap 208, the syringe holder 210, the needle guard 212, and the needle guard spring 214. Additionally, the distal portion 110 can accommodate the dose delivery spring 216, the spring holder 218, the locking unit 220, and the plunger 222. Housing 102 may include a proximal end 104 and a distal end 106. A syringe assembly 202 may be disposed adjacent to proximal end 104. Syringe assembly 202 may be supported within housing 102 via a syringe holder 210. Syringe assembly 202 may be adapted to store a predetermined amount of a medication to be administered. Syringe assembly 202 may include a needle 406 through which the medication is administered into an injection site.

[0019] In one embodiment, the needle shield 408 may be adapted to encapsulate the needle 406. Additionally, the needle shield 408 may be secured with a cap 208, which may be adapted to close the proximal end 104 of the housing 102 when not in use. The cap 208 and the needle shield 408 may be adapted to be removed prior to initiating the drug administration process.

[0020] Furthermore, a needle guard 212 may be disposed to surround the syringe assembly 202. The needle guard 212 may be positioned such that a portion of the needle guard 212 is adapted to extend out of the housing 102 in an initial state. The automatic injector assembly 100 is actuated by a user, for example, by pressing the proximal end 104 against an injection site. When the extension portion is pressed against the injection site, the needle guard 212 may be adapted to retract into the housing 102. In this process, the needle 406 of the syringe assembly 202 is extended to be inserted into the injection site and returns to its original position once the medication has been administered.

[0021] In one embodiment, the needle guard spring 214 may be adapted to support movement of the needle guard 212 within the housing 102 to administer the medication. The needle guard spring 214 may be adapted to be disposed between an inner surface of the housing 102 and an outer surface of the needle guard 212. Thus, the space between the housing 102 and the needle guard 212 accommodates the movement, i.e., compression and expansion, of the needle guard spring 214. The needle guard spring 214 may accommodate the extension and retraction of the needle guard 212 within the housing 102 during administration of the medication.

[0022] The automatic injector assembly 100 may further include a spring holder 218 disposed adjacent the distal end 106 of the housing 102. The spring holder 218 may be adapted to hold the dose delivery spring 216 in a compressed state. The dose delivery spring 216 may be disposed between an inner surface of the housing 102 and an outer surface of the spring holder 218. Such positioning of the dose delivery spring 216 outside the plunger 222 makes it possible to accommodate drugs having higher viscosities by modifying the stiffness of the spring, for example, by increasing the wire diameter or the overall spring diameter. In another embodiment, the dose delivery spring 216 may be disposed inside the spring holder 218. The spring holder 218 may be adapted to be locked with the housing 102. In one embodiment, a locking unit 220 may be disposed inside the spring holder 218 and adapted to maintain the spring holder 218 in a locked state with the housing 102.

[0023] 5 illustrates a cross-sectional view of a portion of the automatic injector assembly 100 illustrating the locking of the spring holder 218 with the housing 102, according to one embodiment of the present disclosure. With reference to FIGS. 4 and 5, the housing 102 may include a pair of stops 402 formed on an interior surface to lock the spring holder 218. Additionally, the spring holder 218 may include a pair of arms 404 adapted to engage with the pair of stops 402 to lock the spring holder 218 to the housing 102.

[0024] Additionally, the spring holder 218 may similarly engage with the locking unit 220. For example, the spring holder 218 may snap-lock with the locking unit 220. In one embodiment, the needle guard 212, when retracted, is adapted to further push the locking unit 220 into the spring holder 218, thereby unlocking the spring holder 218 from the housing 102. Figure 6 shows a cross-sectional view of the automatic injector assembly 100 illustrating the unlocking of the spring holder 218 by movement of the needle guard 212, according to one embodiment of the present disclosure.

[0025] The spring holder 218 is unlocked to allow the plunger 222 to move toward the syringe assembly 202 to administer the medication into the injection site. In one embodiment, the spring holder 218 may be adapted to unlock to release the dose delivery spring 216 from a compressed state and push the plunger 222 toward the syringe assembly 202 based on the compressive force of the dose delivery spring 216. Thus, the plunger 222 may be adapted to move toward the syringe assembly 202 when the spring holder 218 is unlocked. In the locked state of the spring holder 218, movement of the plunger 222 is restricted.

[0026] Plunger 222 may engage with spring holder 218. In one embodiment, plunger 222 may include a plurality of threads formed on its exterior surface. Additionally, spring holder 218 may include a nut (not shown) adapted to engage with the plurality of threads of plunger 222. Plunger 222 may rotate into the nut to control the distance traveled by plunger 222 within housing 102 to administer a drug into an injection site based on a predetermined amount of drug in syringe assembly 202.

[0027] In another embodiment, plunger 222 may include a plurality of threads formed on an interior surface. Additionally, spring holder 218 may include a shaft 224 adapted to engage with the plurality of threads of plunger 222. Plunger 222 may be adapted to rotate within shaft 224 to control the distance traveled by plunger 222 within housing 102 to administer the medication. Thus, the position of engagement of plunger 222 with spring holder 218 may be adapted to vary to control the distance traveled by plunger 222 within housing 102 based on the amount of a predetermined drug in syringe assembly 202.

[0028] 7A shows a cross-sectional view of the automatic injector assembly 100 illustrating the position of the components in an initial state, i.e., before the needle guard 212 is pressed against the injection site, according to one embodiment of the present disclosure. Additionally, FIG. 7B shows a cross-sectional view of the automatic injector assembly 100 illustrating the position of the components after the medication has been administered, according to one embodiment of the present disclosure. As shown, the plunger 222, along with the spring holder 218, moves toward the syringe assembly 202, forcing the medication through the needle 406 and into the injection site.

[0029] In one embodiment, the automatic injector assembly 100 may include means for ensuring that the device is not reused. In particular, engagement of the needle guard 212 with the syringe holder 210 during retraction and extension is such that the needle guard 212 is locked with the syringe holder 210, ensuring that further movement of the needle guard 212 is limited. FIG. 8A illustrates the positioning of the needle guard 212 relative to the syringe holder 210 in an initial state, according to one embodiment of the present disclosure. The syringe holder 210 may include a locking portion 802 formed on its exterior surface. Additionally, the needle guard 212 may include, but is not limited to, a longitudinal groove 804 adapted to receive the locking portion 802 of the syringe holder 210.

[0030] The locking portion 802 may be adapted to move along the longitudinal groove 804 to accommodate relative movement of the needle guard 212 with respect to the syringe holder 210 when the needle guard 212 is retracted into the housing 102. Additionally, the needle guard 212 may include a longitudinal slot 806 formed adjacent to the longitudinal groove 804. The longitudinal slot 806 may be adapted to accommodate return movement of the locking portion 802 when the needle guard 212 returns to its original position after administration of the medication.

[0031] 8B illustrates the positioning of the needle guard 212 relative to the syringe holder 210 after the medication has been administered, according to one embodiment of the present disclosure. As shown, the longitudinal slot 806 may include a stopper slot 808 adapted to retain the locking portion 802 at the end of its return travel, limiting further movement of the needle guard 212 once the medication has been administered. This provision in the automatic injector assembly 100 serves as a safety feature to avoid needlestick injuries, for example, after disposal of the automatic injector assembly 100.

[0032] In one embodiment, automatic injector assembly 100 may include a viewing slot 112 formed on housing 102 for externally viewing the movement of plunger 222. Thus, a user may externally inspect the correct use of automatic injector assembly 100.

[0033] FIG. 9 illustrates an example of how a user may use the automatic injector assembly 100, according to one embodiment of the present disclosure. As shown, the cap 208 is removed. The automatic injector assembly 100 is then positioned at a patient's injection site and held there for a predefined duration. The automatic injector assembly 100 is activated by pressing the needle guard 212 against the injection site. Pressing the needle guard 212 activates needle insertion and dose administration in a single motion by the patient. Specifically, after removing the cap 208, the user presses the proximal end 104 of the automatic injector assembly 100, i.e., the extended portion of the needle guard 212, against the injection site. Once the medication has been delivered, the used pen may be disposed of in a sharps collector.

[0034] As can be seen, the automatic injector assembly 100 of the present disclosure provides a comprehensive and effective approach for delivering medication into a patient's body in various dosages. In operation, a user removes the cap 208 along with the needle shield 408 before positioning the automatic injector assembly 100 at an injection site. The needle guard 212 is then pressed against the injection site. As a result, the needle guard 212 retracts into the housing 102, pushing the locking unit 220 and unlocking the spring holder 218. As a result, expansion of the dose delivery spring 216 causes the spring holder 218, along with the plunger 222, to move toward the syringe assembly 202, forcing the medication through the needle 406 and into the injection site. Furthermore, expansion of the needle guard spring 214 causes the needle guard 212 to lock with the syringe holder 210, restricting further movement while reaching its original position. Once drug delivery is complete and the automatic injector assembly 100 is removed, the needle guard 212 springs back to its initial position covering the needle 406, thereby protecting the user from needlestick injuries.

[0035] Thus, the automatic injector assembly 100 is a drug delivery mechanism that can be used with a variety of different drugs that need to be delivered to a patient through a pre-filled syringe or cartridge. The construction of the automatic injector assembly 100 is such that a single such automatic injector assembly 100 can be used for different injection requirements by changing the operating settings.

[0036] Plunger 222 can engage with spring holder 218 at different positions, for example, via nut or shaft 224, based on different amounts of medication to be administered by automatic injector assembly 100. Furthermore, through the engagement of arm 404 and stopper 402, spring holder 218 is locked to housing 102. Therefore, spring holder 218 and plunger 222 cannot move unless unlocked by needle guard 212. Additionally, once the medication has been administered, needle guard 212 locks with syringe holder 210, ensuring that automatic injector assembly 100 cannot be reused.

[0037] Because the same device is used for different drug dosage requirements, manufacturing costs and inconvenience for the manufacturer will be significantly reduced. Additionally, the overall operating costs of the automatic injector assembly 100 will also be reduced. Furthermore, the handling and maintenance of multiple automatic injectors, as is the case with existing technology, will be significantly reduced. Thus, the automatic injector assembly 100 of the present disclosure is easy to use, cost-effective, compact, operationally efficient, and offers ease of manufacture, maintenance, and operation.

[0038] The autoinjector assembly 100 of the present disclosure may be used to deliver a variety of therapeutic compounds, such as drugs and biologics, including, but not limited to, antibodies, antisense, RNA interference, gene therapy, primary and embryonic stem cells, vaccines, and combinations thereof. For example, the embodiments described herein may be utilized in combination with known monoclonal antibodies, which may include, but are not limited to:

[0039] Abciximab, Abituzumab, Abrilumab, Actoxumab, Adalimumab, Adecatumumab, Aducanumab, Afasevikumab, Afelimomab, Afutuzumab, Alacizumab pegol, ALD518, ALD403, Alemtuzumab, Alirocumab, Altumomab pentetate pentetate, Amatuximab, AMG334, Anatumomab mafenatox, Anetumab ravtansine, Anifrolumab, Anrukinzumab, Apolizumab, Arcitumomab, Ascrinvacumab, Aselizumab, Atezolizumab, Atinumab, Atlizumab, Atorolimumab, Avelumab, Bapineuzumab, Basiliximab iximab, Bavituximab, Bectumomab, Begelomab, Belimumab, Benralizumab, Bertilimumab, Besilesomab, Bevacizumab, Bezlotoxumab, Biciromab, Bimagrumab, Bimekizumab, Bivatuzumab-mertansinemertansine, bleselumab, blinatumomab, blontuvetmab, blosozumab, bococizumab, brazikumab, brentuximab vedotin, briakinumab, brodalumab, brolucizumab, brontuzumab, burosumab, cabilalizumab, canakinumab, cantuzumab mertansine, cantuzumab vedotin ravtansine, Caplacizumab, Capromab pendetide, Casirivimab, Carlumab, Carotuximab, Catumaxomab, cBR96-doxorubicin immunoconjugate, Cedelizumab, Cergutuzumab amunaleukin, Certolizumab pegol, Cetuximab, Sitagumab bogatox, cixutumumab, clazakizumab, clenoliximab, clivatuzumab tetraxetan, codrituzumab, coltuximab ravtansine, conatumumab, concizumab, CR6261, crenezumab, cloteduumab,

[0040] Dacetuzumab, Daclizumab, Dalotuzumab, Dapirolizumab pegol, Daratumumab, Detrekumab, Demcizumab, Denintuzumab mafodotin, Denosumab, Depatuxizumab mafodotin, Derlotuximab biotin Biotin, Detumomab, Dinutuximab, Diridavumab, Domagrozumab, Dorlimomab aritox, Drozitumab, Durigotumab, Dupilumab, Durvalumab, Dusigitumab, Ecromeximab, Eculizumab, Edobacomab, Edrecolomab, Efalizumab ), Efungumab, Eldelumab, Elgemtumab, Elotuzumab, Elsilimomab, Emactuzumab, Emibetuzumab, Emicizumab, Enavatuzumab, Enfortumab vedotin, Enlimomab pegol, Enoblituzumab, Enokizumab, Enoticumab, Ensituximab, Epitumomab situxetanCituxetan, Epratuzumab, Erenumab, Erlizumab, Ertumaxomab, Etaracizumab, Etrolizumab, Evinacumab, Evolocumab, Exbivirumab, Fanolesomab, Faralimomab, Farletuzumab, Fasinumab, FBTA05, Felvizumab, Fezakinumab, Fivatuzumab, Ficlatuzumab, Figitumumab, Filibumab, Flanvotumab, Fletikumab, Fontolizumab, Foralumab, Foravirumab, Fresolimumab, Fulranumab, Futuximab, Galcanezumab, Galiximab, Ganitumab, Gantenerumab, Gavilimomab, Gemtuzumab Ozogamicin ozogamicin), Gevokizumab, Girentuximab, Glembatumumab vedotin, Golimumab, Gomiliximab, Guselkumab,

[0041] Ibalizumab, Ibritumomab tiuxetan, Icrucumab, Idarucizumab, Igovomab, IMA-638, IMAB362, Imalumab, Imciromab, Imdevimab, Imgatuzumab, Inclacumab, Indatuximab ravtansine, Indusatumab vedotin vedotin, inebilizumab, infliximab, inolimomab, inotuzumab ozogamicin ozogamicin, intetumumab, ipilimumab, iratumumab, isatuximab, itolizumab, ixekizumab, keliximab, labetuzumab, lambrolizumab, lampalizumab, lanadelumab, landogrozumab, laprituximab emtansine emtansine, LBR-101 / PF0442g7429, lebrikizumab, lemaresomab, lendalizumab, lenzilumab, lerdelimumab, lexatumumab, ribivirumab, rifastuzumab vedotin, ligelizumab, rilotomab satetraxetansatetlaxetan, lintuzumab, lirilumab, lodelcizumab, lokivetmab, lorvotuzumab mertansine, lucatumumab, lulizumab pegol pegol, Lumiliximab, Ramretuzumab, LY2951742, Mapatumumab, Margetuximab, Maslimomab, Matuzumab, Mavrilimumab, Mepolizumab, Metelimumab, Milatuzumab, Minretumomab, Mirvetuximab-Soravtansine soravtansine, Mitumomab, Mogamulizumab, Monalizumab, Morolimumab, Motavizumab, Moxetumomab pasudotox, Muromonab-CD3, Nacolomab tafenatox, Namilumab, Naptumomab estafenatox, Naratuximab emtansine Emtansine, Narnatumab, Natalizumab, Navicixizumab, Navivumab, Nebacumab, Necitumumab, Nemolizumab, Nerelimomab, Nesvacumab, Nimotuzumab, Nivolumab, Nofetumomab-merpentanemerpentan)、

[0042] Obiltoxaximab, Obinutuzumab, Ocaratuzumab, Ocrelizumab, Odulimomab, Ofatumumab, Olaratumab, Olokizumab, Omalizumab, Onartuzumab, Ontuxizumab, Opicinumab, Oportuzumab monatox, oregovomab, orticumab, otelixizumab, otletuzumab, oxelumab, ozanezumab, ozoralizumab, pagibaximab, palivizumab, pamrevlumab, panitumumab, pancomab, panobac umab, Parsatuzumab, Pascolizumab, Pasotuxizumab, Pateclizumab, Patritumab, Pembrolizumab, Pemtumomab, Perakizumab, Pertuzumab, Pexelizumab, Pidilizumab, Pinatuzumab Vedotin vedotin, pintumomab, placulumab, plozalizumab, pogalizumab, polatuzumab vedotinVedotin, Ponezumab, Prezalizumab, Priliximab, Pritoxaximab, Pritumumab, PRO140, Quilizumab, Racotumomab, Radretumab, Rafivirumab, Ralpancizumab mab, ramucirumab, ranibizumab, raxibacumab, rifanezumab, regavirumab, reslizumab, rilotumumab, rinucumab, risankizumab, rituximab, rivabazumab pegol pegol, Robatumumab, Roledumab, Romosozumab, Rontalizumab, Rovalpituzumab tesirine, Rovelizumab, Ruplizumab, Sacituzumab govitecan, Samalizumab, Sapelizumab, Sarilumab, Satumomab pendetidependetide, secukinumab, seribantumab, setoxaximab, sevirumab, SGN-CD19A (SGN-CD19A), SGN-CD33A (SGN-CD33A), sibrotuzumab, sifalimumab, siltuximab, simtuzumab, siplizumab, sirukumab, sofituzumab vedotin vedotin), solanezumab, solitomab, sonepcizumab, sontuzumab, stamulumab, sulesomab, suvizumab,

[0043] Tavalumab, Tacatuzumab tetraxetan, Tadocizumab, Talizumab, Tamtuvetmab, Tanezumab, Taplitumomab paptox, Tarextumab, Tefibazumab, Telimomab aritox, tenatumomab, teneliximab, teplizumab, teprotumumab, tesidolumab, tetulomab, tezepelumab, TGN1412, ticilimumab, tigatuzumab, tildrakizumab, timolumab, tisotumab vedotin vedotin, TNX-650, tocilizumab, toralizumab, tosatoxumab, tositumomab, tovetumab, tralokinumab, trastuzumab, trastuzumab emtansine, TRBS07, tregalizumab, tremelimumab, trevogrumab, tucotuzumab Celmoleukin, Tuvirumab, Ublituximab, Ulocuplumab, Urelumab, Urtoxazumab, Ustekinumab, Utomilumab, Vadastuximab-Talilinetalirine, vandortuzumab vedotin, vantictumab, vanucizumab, vapaliximab, varlilumab, vatelizumab, vedolizumab, veltuzumab, vepalimomab, vesencumab, visilizumab, vobarilizumab, volociximab, vorsetuzumab mafodotin, votumumab, xentuzumab, zalutumumab, zanolimumab, zatuximab, ziralimumab, and zolimomab aritox, or combinations thereof.

[0044] Although specific language has been used to describe the present subject matter, no limitations are intended thereby. As will be apparent to those skilled in the art, various operational modifications may be made to the methods to implement the inventive concepts taught herein. The figures and the foregoing description provide examples of embodiments. Those skilled in the art will understand that one or more of the described elements may be combined into a single functional element. Alternatively, certain elements may be divided into multiple functional elements. Elements of one embodiment may be added to another embodiment.

Claims

1. An automatic injector assembly (100) comprising: a housing (102) having a proximal end (104) and a distal end (106); a syringe assembly (202) disposed adjacent to the proximal end (104) of the housing (102) and adapted to store a predetermined amount of a medication to be administered through the needle (406); a needle guard (212) disposed around the syringe assembly (202) and adapted such that a portion of the needle guard (212) extends out of the housing (102) in an initial state and retracts into the housing (102) when the portion is pressed onto the injection site; a spring holder (218) disposed adjacent to the distal end (106) of the housing (102) and adapted to hold the dose delivery spring (216) in a compressed state; a locking unit (220) disposed inside the spring holder (218) and adapted to maintain the spring holder (218) locked with the housing (102); and a plunger (222) adapted to engage with the spring holder (218) and move toward the syringe assembly (202) when the spring holder (218) is unlocked, the position of the plunger's engagement with the spring holder (218) adapted to vary to control the distance traveled by the plunger (222) within the housing (102) based on the amount of a predetermined drug in the syringe assembly (202); Including, When the needle guard (212) is retracted, it is adapted to push the locking unit (220) further into the spring holder (218), unlocking the spring holder (218) from the housing (102) and moving the plunger (222) towards the syringe assembly (202) for administration of the medication into the injection site; wherein the plunger (222) has a plurality of threads formed on its exterior surface; The spring holder (218) includes a nut adapted to engage a plurality of threads of the plunger (222), and the plunger (222) is rotated into the nut to control the travel distance of the plunger (222) within the housing (102) to administer a drug into the injection site based on a predetermined amount of drug in the syringe assembly (202). or wherein the plunger (222) has a plurality of threads formed on its interior surface; the spring holder (218) includes a shaft (224) adapted to engage with a plurality of threads of the plunger (222), and the plunger (222) is rotated into the shaft (224) to control the travel distance of the plunger (222) within the housing (102) to administer the drug into the injection site based on a predetermined amount of drug in the syringe assembly (202).

2. 2. The automatic injector assembly of claim 1, wherein the needle guard is adapted to press against the injection site, extend to allow the needle of the syringe assembly to be inserted into the injection site, and return to its original position when the medication has been administered.

3. a syringe holder (210) adapted to support the syringe assembly (202) within the housing (102); and a needle guard spring (214) adapted to be disposed between an inner surface of the housing (102) and an outer surface of the needle guard (212), the needle guard spring (214) adapted to support movement of the needle guard (212) for administration of a drug within the housing (102); The automatic injector assembly (100) of claim 1.

4. a housing (102) having a pair of stoppers (402) formed on its interior surface; and a spring holder (218) including a pair of arms (404) adapted to engage a pair of stoppers (402) to lock the spring holder (218) to the housing (102), limiting the movement of the plunger (222); 10. The automatic injector of claim 1.

5. 2. The automatic injector assembly (100) of claim 1, wherein the spring holder (218) is adapted to unlock the dose delivery spring (216), release the dose delivery spring (216) from a compressed state, and push the plunger (222) toward the syringe assembly (202) based on the compressive force of the dose delivery spring (216).

6. a needle shield (408) adapted to enclose the needle (406); and a cap (208) secured to the needle shield (408) and adapted to close the proximal end (104) of the housing (102) when the proximal end (104) is not in use; The cap (208) and needle shield (408) are adapted to be removed prior to pressing the needle guard (212) against an injection site for administering a drug; The automatic injector assembly (100) of claim 1.

7. a syringe holder (210) having a locking portion (802) formed on an exterior surface thereof; and A needle guard (212) comprising: a longitudinal groove (804) adapted to receive a locking portion (802) of the syringe holder (210) when the needle guard (212) retracts into the housing (102), the locking portion (802) adapted to move along the longitudinal groove (804) to accommodate relative movement of the needle guard (212) with respect to the syringe holder (210); and a longitudinal slot (806) formed adjacent to the longitudinal groove (804) and adapted to accommodate the return movement of the locking portion (802) when the needle guard (212) returns to its original position after administration of the medication, the longitudinal slot (806) including a stopper slot (808) adapted to hold the locking portion (802) at the end of the return movement and limit further movement of the needle guard (212) once the medication has been administered; the needle guard (212), The automatic injector assembly (100) of claim 3.

8. 10. The automatic injector assembly (100) of claim 1, including a viewing slot (112) formed on the housing (102) to allow movement of the plunger (222) to be viewed externally.

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