Neutron Capture Therapy System

Abstract

To provide a neutron capture therapy system which has good anti-activation performance. and can further attenuate the radiation in comparison to a conventional reinforced concrete structure.SOLUTION: A neutron capture therapy system includes a neutron generating device and a beam shaping assembly. The neutron capture therapy system further includes a concrete wall accommodating the neutron generating device and the beam shaping assembly and shielding radiations generated by the neutron generating device and the beam shaping assembly, and the concrete wall and a reinforcing portion at least partially disposed in the concrete wall are provided to support the beam shaping assembly, and more than 90% (weight percent) of a material of the reinforcing portion is composed of at least one element of C, H, O, N, Si, Al, Mg, Li, B, Mn, Cu, Zn, S, Ca, and Ti.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a radiation delivery system, and more particularly to a neutron capture therapy system. [Background technology]

[0002] With the development of atomic science, radiation therapy using cobalt-60, linear accelerators, electron beams, etc. It has already become one of the main methods of cancer treatment. However, conventional photon or electron therapy is The beam kills tumor cells by limiting their physical conditions, while also targeting many normal tissues along the beam path. Also, tumor cells have different levels of sensitivity to radiation, Conventional radiotherapy is difficult to treat highly radioresistant malignant tumors (e.g., glioblastoma multiforme (gLiob Treatment for melanoma (melanoma multiforme) The effect is not good.

[0003] To reduce radiation damage to normal tissue surrounding the tumor, chemotherapy (cHemotHe Targeted therapy in radiation therapy is used in radiation therapy. Currently, the relative biological effectiveness (RBI) of Radiation sources with high radiation effectiveness (RBE) are being actively developed (e.g. (For example, proton therapy, heavy particle therapy, neutron capture therapy, etc.) Of these, neutron capture therapy is For example, in boron neutron capture therapy, boron-containing The drug specifically collects in tumor cells, and by combining this with highly precise control of the neutron beam, it is possible to achieve a level of efficacy that is superior to conventional methods. It offers a better cancer treatment option compared to conventional radiation.

[0004] Various types of radiation may be produced during the radiation therapy process, such as boron neutron capture therapy. It produces neutrons and photons with low to high energy levels, and these radiations are harmful to humans. They can cause different degrees of damage to normal tissues in the body. In this case, it is necessary to achieve effective treatment while minimizing the effects on the external environment, medical personnel, or normal tissues of the irradiated subject. How to reduce radiation contamination from radiation therapy equipment is a very important topic. are typically placed in buildings of concrete construction and are designed to absorb radiation that may be generated by the equipment. In general reinforced concrete structures, after the rebar is activated by neutrons, It produces radioactive isotopes with long half-lives, for example, cobalt-60 has a half-life of 5.27 years. , forming radioactive waste with long decay times, which has adverse effects on the environment and radiation safety.

[0005] Therefore, it is necessary to provide a new technical means to solve the above problems. Summary of the Invention [Problem to be solved by the invention]

[0006] In order to solve the above problem, a neutron capture therapy system according to one aspect of the present application is the neutron generating device includes an accelerator and a target; The charged particle beam accelerated by the accelerator interacts with the target to generate a neutron beam. The beam shaper includes a reflector, a moderator, a thermal neutron absorber, a radiation shield, and a beam an outlet, the moderator directing neutrons generated by the target to epithermal neutron energy The reflector surrounds the moderator and directs the escaping neutrons toward the moderator. This improves the epithermal neutron beam intensity, and the thermal neutron absorber absorbs the superficial normal tissue during treatment. To avoid excessive dose to the tissue, the radiation shield absorbs thermal neutrons. A body is provided behind the reflector surrounding the beam exit, and normal tissue lines in the non-irradiated area are To reduce the amount of neutrons and photons leaking out, the neutron generator and the a concrete wall that houses a frame forming body, and the concrete wall and at least a portion thereof The reinforcing portion provided in the concrete wall supports the beam shaper, and the reinforcing portion More than 90% (by weight) of the material is C, H, O, N, Si, Al, Mg, Li, B It consists of at least one element selected from the group consisting of Mn, Cu, Zn, S, Ca, and Ti. The port structure is designed to absorb neutrons and other radiation that leak during the operation of the neutron capture therapy system. The reinforcement improves the rigidity of the concrete, improving its tensile strength. The load-bearing capacity can be improved, and the material of the reinforcement part has a small cross section with neutrons, or It consists of elements with short half-lives of radioactive isotopes produced after activation by neutrons, The radioactivity induced by neutron activation is small, so the dose from secondary radiation is reasonably suppressed. In addition, this will be more advantageous for future dismantling of the equipment.

[0007] Furthermore, the reinforcing portion is made of a material having an elastic modulus of 40 GPa or more and a yield strength of 100 MPa or more. , and the ultimate strength is 200 MPa or more.

[0008] Furthermore, the half-life of the radioactive isotope generated after the reinforcing portion is activated by neutrons is less than a year old.

[0009] Furthermore, at least a part of the material of the reinforcing portion is an aluminum alloy or a carbon fiber composite material. or glass fiber composite. After being activated by neutrons, aluminum has a half-life The activation resistance of carbon fiber composites or glass fiber composites is high, and the Compared to the sintered structure, the radioactivity induced by neutron activation within a limited time is significantly reduced. Lower.

[0010] The neutron capture therapy system further includes a treatment table and a collimator, is provided at the rear of the beam outlet to collect neutrons and The electron beam passes through the beam shaper and collimator and is irradiated onto the subject on the treatment table. A radiation shielding device is installed between the object to be irradiated and the beam outlet, and the beam emitted from the beam outlet is The target may be one or more targets, and the target may be a shield against radiation reaching normal tissue of the subject. The charged particle beam selectively interacts with or simultaneously interacts with one or several of the targets. By interacting with multiple targets, one or more therapeutic neutron beams are generated and Depending on the number of targets, there may be one or more beam shapers, collimators, and treatment tables. stomach.

[0011] Furthermore, the neutron capture therapy system further includes a charged particle beam generation chamber and an irradiation chamber. The subject on the treatment table is treated by neutron beam irradiation in the irradiation chamber, and the The charged particle beam generating chamber houses the accelerator, and the concrete wall is The partition wall completely separates the irradiation chamber from the charged particle beam generation chamber. The irradiation chamber and the charged particle beam generating chamber may be partially separated. The irradiation chamber and the charged particle beam generating chamber may be connected to each other. Alternatively, a separate irradiation room may be provided for each treatment table.

[0012] Preferably, the beam shaper is provided within the partition wall and is supported by the partition wall. a receiving cavity is provided in the partition wall, and the beam shaper is disposed in the receiving cavity; The partition wall is mounted within the housing, and the receiving cavity penetrates the partition wall along the thickness direction.

[0013] Preferably, the neutron generator further comprises a charged particle beam generated by an accelerator. a beam transfer section for transferring the beam to the target, and a through hole is provided in the partition wall, and the beam The beam transfer portion passes through the through hole, and at least a portion of the reinforcing portion is provided within the partition wall. The beam shaper is supported by the reinforcing portion.

[0014] According to another aspect of the present invention, there is provided a method for adjusting the beam quality of a neutron beam generated by a neutron generating device. The support device for supporting the beam shaper is a receiving case in which the beam shaper is mounted. a concrete wall and a reinforcement at least partially disposed within the concrete wall. The concrete structure shields neutrons and other radiation that leaks during operation. The beam shaper is sensitive to deformation and the support structure is sufficiently rigid. The reinforcement part installed in the concrete is required to improve the rigidity of the concrete. This increases the strength, improves the tensile strength, and improves the load-bearing capacity.

[0015] Furthermore, the reinforcing portion is made of a material having an elastic modulus of 40 GPa or more and a yield strength of 100 MPa or more. , and the ultimate strength is 200 MPa or more.

[0016] Furthermore, 90% (by weight) or more of the material of the reinforcing portion is C, H, O, N, Si, At least one element selected from Al, Mg, Li, B, Mn, Cu, Zn, S, Ca, and Ti The material of the reinforcement part has a small cross section with neutrons or is activated by neutrons. It consists of elements with short half-lives of radioactive isotopes produced after activation by neutrons. The induced radioactivity is small, so in addition to rationally limiting the dose from secondary radiation, future This is more advantageous for dismantling the device.

[0017] Furthermore, the half-life of the radioactive isotope generated after the reinforcing portion is activated by neutrons is less than a year old.

[0018] Furthermore, the receiving cavity is a through hole formed in the concrete wall, The reinforcing portion includes a circular ring, a framework, and a reinforcing bar, and the circular ring is provided to surround the beam shaping body. The framework is provided around the ring, and the reinforcing bars are horizontal, vertical and concrete. The reinforcement bars are distributed in the concrete at predetermined intervals along the thickness direction of the concrete, and the reinforcement bars are The reinforcement bar has at least a portion passing through the framework or abutting against the framework. The material of the ring and the frame is an aluminum alloy, a carbon fiber composite, or a glass The lath fiber composite material is used, and the material of the distribution reinforcement is steel, aluminum alloy, or carbon fiber composite. or glass fiber composite. The ring and framework improve the stiffness of the concrete and increase its tensile strength. The reinforcement prevents cracks in the concrete and improves the overall performance of the wall. can be done.

[0019] Furthermore, the aluminum alloy is an aluminum-magnesium alloy, and the carbon fiber The fiber composite material is a carbon fiber resin composite material, and the glass fiber composite material is a glass fiber resin composite material. The ring is made of a shape or a reinforcement, and the framework is made of a shape or a reinforcement. When the framework is a frame, it includes horizontal frame beams and vertical frame columns. The horizontal framing beams and the vertical framing columns are connected by bolts or welded. Concrete has high compressive strength, but its tensile strength is low, and strain increases over time under normal stress. The tensile strength and shear strength of aluminum magnesium alloy extrusions increased slowly with time. High strength, high stiffness, and strain that increases slowly with time under normal stress. The tensile strength of the carbon fiber resin composite or glass fiber resin composite is high, and the concrete When the framework is made of steel, it can compensate for the lack of mechanical properties and material properties. The horizontal frame includes horizontal longitudinal reinforcement and ribs, and the vertical frame includes horizontal longitudinal reinforcement and ribs. The concrete has high compressive strength and aluminum-magnesium Aluminum magnesium alloy bars have high tensile load capacity, and aluminum magnesium alloy bars are used in areas that are subject to tension. When placed, it can compensate for the lack of tensile strength of concrete, and carbon fiber resin composite or The high tensile strength of the glass fiber composite material means that the placement of stiffening rods can improve the shear performance of the wall. It can be raised.

[0020] Preferably, the reinforcing portion is a first reinforcing portion provided in the concrete wall. and a second reinforcing portion at least partially extending from the concrete wall.

[0021] Furthermore, the first reinforcing portion includes a circular ring, a framework, and a distribution reinforcement, and the circular ring is connected to the beam. The framework is provided around the ring, and the distribution reinforcement is horizontal. and distributed in the concrete at predetermined intervals along the thickness direction of the concrete, At least a part of the reinforcement passes through or contacts the framework, and the reinforcement is At least a portion of the ring is in contact with the ring, and the ring and the frame are made of aluminum alloy or carbon fiber. The material of the distribution bars is steel, aluminum alloy, or The ring and frame are made of carbon fiber composite or glass fiber composite to increase the rigidity of the concrete. The reinforcement prevents concrete cracking and improves the overall performance of the wall. It can be improved.

[0022] Furthermore, the aluminum alloy is an aluminum-magnesium alloy, and the carbon fiber The fiber composite material is a carbon fiber resin composite material, and the glass fiber composite material is a glass fiber resin composite material. The circular ring is made of a shape or a reinforcement, and the framework is a horizontal framework shape beam or a horizontal The horizontal frame includes horizontal longitudinal reinforcement and ribs. The compressive strength of the concrete is high, but its tensile strength is low and strain increases slowly with time under normal stress. As a result, the aluminum magnesium alloy extrusions have high tensile strength and shear strength, and high rigidity. and the strain does not increase slowly with time under normal stress, and the aluminum matrix Magnesium alloy bars have high tensile strength, and carbon fiber resin composite or glass fiber resin composite bars It has high tensile strength and can compensate for the lack of concrete mechanical properties and material properties. By placing the reinforced concrete in place, the shear performance of the wall can be improved.

[0023] Furthermore, the second reinforcing portion is connected to a horizontal support plate and the support plate and the first reinforcing portion. and a side plate, the receiving cavity being formed in the support plate.

[0024] Furthermore, a flange is provided on the side of the support plate facing the first reinforcing portion, and the flange The holder forms the receiving cavity and also regulates the position of the beam shaping body in the horizontal direction. A through hole is formed in the support plate, and the neutron beam passes through the beam shaper and exits from the through hole. It comes out.

[0025] A building for a neutron irradiation system according to a further aspect of the present invention is a concrete structure for housing the concrete, a reinforcement portion being provided within the concrete structure, and the reinforcement 90% or more (by weight) of the material in the strong part is C, H, O, N, Si, Al, Mg, or Li It is composed of at least one element selected from the group consisting of B, Mn, Cu, Zn, S, Ca, and Ti. The cleat structure is designed to protect against neutrons and other radiation leaking during the operation of the neutron irradiation system. The reinforcement improves the rigidity of the concrete, improving its tensile strength. The load-bearing capacity can be improved, and the material of the reinforcement part has a small cross section with neutrons, or It consists of elements with short half-lives of radioactive isotopes produced after activation by neutrons, The radioactivity induced by neutron activation is small, so the dose from secondary radiation is reasonably suppressed. In addition, this will be more advantageous for future dismantling of the equipment.

[0026] Furthermore, the reinforcing portion includes horizontal and / or vertical distribution reinforcement, and the horizontal and / or vertical distribution reinforcement The reinforcement bars are installed horizontally, vertically and at predetermined intervals along the thickness direction of the concrete structure. Distributed within the cleat structure, the distribution reinforcement prevents concrete cracking and improves the overall performance of the wall. It can be done.

[0027] Furthermore, the reinforcing portion is made of a material having an elastic modulus of 40 GPa or more and a yield strength of 100 MPa or more. , and the ultimate strength is 200 MPa or more.

[0028] Furthermore, the half-life of the radioactive isotope generated after the reinforcing portion is activated by neutrons is less than a year old.

[0029] Furthermore, at least a part of the material of the reinforcing portion is an aluminum alloy or a carbon fiber composite material. or glass fiber composite. After being activated by neutrons, aluminum has a half-life The activation resistance of carbon fiber composites or glass fiber composites is high, and the Compared to the sintered structure, the radioactivity induced by neutron activation within a limited time is significantly reduced. Lower.

[0030] Furthermore, the aluminum alloy is an aluminum-magnesium alloy, and the carbon fiber The fiber composite material is a carbon fiber resin composite material, and the glass fiber composite material is a glass fiber resin composite material. The concrete of the concrete structure is boron-containing barite concrete. Aluminum magnesium alloy, carbon fiber composite or glass fiber composite has excellent mechanical properties. Boron-containing concrete has better neutron absorption properties and is In addition to improving the radiation shielding effect of concrete, it also reduces the neutron exposure of metal materials in concrete. The amount can be reduced. [Brief explanation of the drawings]

[0031] [Figure 1]1 is a structural schematic diagram of a neutron capture therapy system according to an embodiment of the present invention; [Figure 2] 1 is a schematic diagram of a support structure of a beam shaper of a neutron capture therapy system according to a first embodiment of the present invention. [Figure 3] FIG. 3 is a schematic cross-sectional view of FIG. 2 taken along line AA. [Figure 4] FIG. 3 is a schematic cross-sectional view of FIG. 2 taken along line BB. [Figure 5] FIG. 3 is a schematic cross-sectional view of FIG. 2 taken along CC line. [Figure 6] FIG. 10 is a schematic diagram of a support structure of a beam shaper of a neutron capture therapy system according to a second embodiment of the present invention. [Figure 7] FIG. 7 is a schematic cross-sectional view of FIG. 6 taken along the line DD. [Figure 8] FIG. 7 is a schematic cross-sectional view of FIG. 6 taken along the line E-E. [Figure 9] FIG. 7 is a schematic cross-sectional view of FIG. 6 taken along the line F-F. [Figure 10] FIG. 10 is a schematic diagram of a support structure of a beam shaper of a neutron capture therapy system according to a third embodiment of the present invention. [Figure 11] FIG. 11 is a schematic cross-sectional view of FIG. DETAILED DESCRIPTION OF THE INVENTION

[0032] The following detailed description of the embodiments of the present invention will be given with reference to the accompanying drawings, which will enable those skilled in the art to can be implemented by reference to the text of the specification.

[0033] As shown in FIG. 1, the neutron irradiation system in this embodiment preferably uses boron neutrons. Capture therapy system 100, neutron generator 10, beam shaper 20, collimator 30, The neutron generator 10 includes an accelerator 11 and a target T. The accelerator 11 is Charged particles (e.g., protons, deuterium nuclei, etc.) are accelerated and A charged particle beam P is generated, and the charged particle beam P is irradiated onto the target T and interacts with the target T to produce a neutral A neutron beam N is generated, and the target T is preferably a metal target. the available neutron production rate and energy, the available accelerated charged particle energy and current magnitude, The appropriate nuclear reaction is selected according to the physical and chemical properties of the metal target, and is constantly being discussed. The nuclear reaction that occurs is 7 Li(p,n) 7 Be affected 9 Be(p,n) 9 B and these two types of reactions Both are endothermic reactions. The energy thresholds of the two nuclear reactions are 1.881Me V and 2.055 MeV, and the ideal neutron source for boron neutron capture therapy is keV energy. Because it is a low-rank epithermal neutron, theoretically it is possible to use a proton with an energy just slightly higher than the threshold. Bombarding a lithium metal target with This allows for clinical use without the need for additional deceleration treatment, but lithium metal ( Two types of targets, Li and beryllium metal (Be), and proton action cross sections at threshold energies is not high and to generate a sufficiently large neutron flux, high-energy protons are generally used. The ideal target is one with a high neutron production rate and The energy distribution is close to the epithermal neutron energy region (described in detail below), It does not generate excessively strong penetrating radiation, is safe, inexpensive, easy to operate, and has high temperature resistance. However, in reality, it is not possible to find a nuclear reaction that meets all the requirements. In the present embodiment, a target made of lithium metal is employed. As is well known, the material of the target T is made of metal materials other than lithium and beryllium. It may be made of, for example, tantalum (Ta) or tungsten (W); The get T may be disk-shaped or may have other solid shapes, or may be made of liquid material (liquid The accelerator 11 may be a linear accelerator, a cyclotron, a synchrotron, or the like. , a synchrocyclotron, and the neutron generating device 10 may be a nuclear reactor. It does not use an accelerator and a target. The neutron source for boron neutron capture therapy comes from a nuclear reactor or Despite the nuclear reaction between the accelerator charged particles and the target, the product is actually a mixture of It is a radiation field, i.e. the beam contains neutrons and photons ranging from low to high energy. Boron neutron capture therapy for deep tumors contains a large amount of other radiation, except for epithermal neutrons. The higher the dose, the greater the proportion of normal tissues that will cause non-selective dose precipitation, and therefore Radiation that causes unnecessary doses of radiation should be reduced as much as possible. For tissues, avoid too much radiation of any kind, as well as causing unnecessary dose deposition. should be.

[0034] The neutrons N generated by the neutron generator 10 pass through the beam shaper 20 and the collimator 30 in order. The beam shaper 20 is connected to the neutron generator 1. The collimator 30 can adjust the beam quality of the neutron beam N generated by the collimator 30. It is used to collect the electron beam N and provide the neutron beam N with high targetability during the treatment process. By adjusting the collimator 30, the beam direction and the beam on the treatment couch 40 can be controlled. The positional relationship between the treatment table 40 and the object to be irradiated 200 can be adjusted. The position can also be adjusted to target the beam to tumor cells M within the subject 200. These adjustments can be done manually or automatically by a series of control mechanisms. As can be appreciated, the present invention may also be implemented without a collimator, and the beam After exiting the beam shaper 20, the beam is irradiated onto the object 200 to be irradiated on the treatment table 40.

[0035] The beam shaper 20 further includes a reflector 21, a moderator 22, a thermal neutron absorber 23, and a radiation seal. The neutron generator 10 includes a beam exit 25 and a beam body 24. The neutrons generated by the neutron generator 10 are -Because of the wide spectrum, epithermal neutrons can meet the therapeutic needs, but other types of neutrons and and photon content should be reduced as much as possible to avoid causing injury to the operator or the subject. Therefore, the neutrons emitted from the neutron generator 10 pass through the moderator 22 and are transported to the high-speed neutral Neutron energy (>40keV) in the epithermal neutron energy range (0.5eV-40keV) It is necessary to adjust the energy level to 0.5 eV and reduce thermal neutrons (<0.5 eV) as much as possible. is made of a material with a large cross section for fast neutrons and a small cross section for epithermal neutrons, In a preferred embodiment, the moderator 13 is made of D2O, AlF3, Fluental, CaF2, The reflector 21 is made of at least one of Li2CO3, MgF2, and Al2O3. The neutrons that have passed through the moderator 22 and are scattered to the surrounding area are reflected back into the neutron beam N. It is preferable to use a material with high neutron reflectivity and improve the utilization rate of neutrons by irradiating it. For example, the reflector 21 is made of at least one of Pb and Ni; The rear part has a thermal neutron absorber, which is made of a material with a large cross section that interacts with thermal neutrons, and is preferably In a preferred embodiment, the thermal neutron absorber 23 is made of Li-6, and the thermal neutron absorber 23 is moderated. The thermal neutrons passing through the body 22 are absorbed to reduce the content of thermal neutrons in the neutron beam N, and the cured Avoid excessive dose to superficial normal tissue during treatment; the radiation shield 24 It is installed at the rear of the reflector surrounding the beam outlet, and is used to detect neutrons leaking from parts other than the beam outlet 25. The material of the radiation shield body 24 is a photon shield material. The radiation shielding body includes at least one of the neutron shielding materials. The 24 materials are photon shielding material lead (Pb) and neutron shielding material polyethylene (PE). A collimator 30 is provided behind the beam outlet 25, and the thermal radiation emitted from the collimator 30 The neutron beam is irradiated to the irradiated body 200, and after passing through the superficial normal tissue, it is slowed down to thermal neutrons. As can be seen, the beam shaper 20 can also include other structures. It is sufficient to obtain the epithermal neutron beam required for treatment.

[0036] After the subject 200 takes or is injected with a boron (B-10) drug, the boron drug selectively Concentrated in tumor cells M, followed by boron (B-10) drug with high capture cross section for thermal neutrons. Taking advantage of the characteristics of having 10 B(n, α) 7 by Li neutron capture and fission reactions 4 He and 7 It produces two heavy charged particles of Li. The average energy of the two charged particles is about 2.33 MeV, a high linear energy transfer , LET), which has the characteristics of a short range, and the linear energy transfer and range of the α short particle are 150 keV / μm, 8 μm, 7 Li heavy charged particle 175 keV / μm, 5 μm The total range of the two particles is approximately the size of one cell, so the impact on the organism is Radiation injury can be limited to the cell hierarchy without causing significant damage to normal tissues. , achieving the purpose of killing tumor cells locally.

[0037] In this embodiment, a radiation shielding device 50 is further provided between the irradiation object 200 and the beam exit 25. The beam exiting from the beam outlet 25 is shielded from radiation to normal tissue of the subject, It should be understood that the radiation shielding device 50 need not be installed.

[0038] The boron neutron capture therapy system 100 is entirely contained within a concrete building. Specifically, the boron neutron capture therapy system 100 further includes an irradiation chamber 101 and a charging chamber 102. The particle beam generating chamber 102 includes a particle beam generating chamber 101, and the object 200 to be irradiated on the treatment table 40 is irradiated in the irradiation chamber 101. The neutron beam N irradiation treatment is performed, and the charged particle beam generation chamber 102 houses the accelerator 11. The beam shaper 20 is separated from the irradiation chamber 101 by a partition wall 103 between the charged particle beam generation chamber 102. As can be seen, the partition wall 103 separates the irradiation chamber 101 and the charged particle beam generation chamber 102. The irradiation chamber 101 and the charged particle beam generation chamber 102 may be completely separated. The irradiation chamber 101 and the charged particle beam generation chamber 102 may be partially separated, and the irradiation chamber 101 and the charged particle beam generation chamber 102 may be connected. The target T may be one or more, and the charged particle beam P selectively penetrates the target T. It acts on one or several targets T or on multiple targets T simultaneously. By doing so, one or more therapeutic neutron beams N can be generated. Depending on the number of beam shapers 20, collimators 30, and treatment tables 40, one or more beam shapers 20, collimators 30, and treatment tables 40 may be provided. Multiple treatment units may be installed in the same irradiation room, with each treatment unit having its own individual irradiation unit. A chamber may be provided.

[0039] The irradiation chamber 101 and the charged particle beam generation chamber 102 are separated by a concrete wall W (including a partition wall 103). The concrete structure is a space surrounded by a boron neutron capture therapy system. It is possible to shield neutrons and other radiation that leak during the operation of the system 100. The concrete wall W has a reinforcement portion (hereinafter, referred to in detail) at least partly provided in the concrete. By including the CFRP (which we will introduce), rigidity is improved, tensile strength is improved, and load-bearing capacity is improved. The reinforced part is made of a material with an elastic modulus of 40 GPa or more, a yield strength of 100 MPa or more, and an ultimate strength of At the same time, the material of the reinforcement part must have a small cross section with neutrons or is a radioisotope produced after activation by neutrons with a short half-life (less than 1 year). Specifically, 90% (by weight) or more of the material of the reinforcing part is C, H, O At least one of N, Si, Al, Mg, Li, B, Mn, Cu, Zn, S, Ca, and Ti In this embodiment, at least a part of the material of the reinforcing portion is aluminum. alloy, carbon fiber composite, glass fiber composite, or a combination thereof. The alloy may be selected to be at least partially an aluminum-magnesium alloy, and aluminum After being activated by neutrons, nium has a short half-life of only 2.2 minutes, In reinforced concrete structures, elements such as iron, cobalt, and nickel, which are abundant in the reinforcing bars, After being activated by cobalt, it has a long half-life. For example, the half-life of cobalt-60 is 5.27 years. When an aluminum magnesium alloy is used, the material is activated by neutrons within a limited time. This significantly reduces the induced radioactivity, which not only reasonably limits the dose from secondary radiation but also This will be more advantageous for dismantling existing equipment. Aluminum magnesium alloys have excellent mechanical properties. As you can see, other aluminum alloys can be selected. If you select composite or glass fiber composite, it is a composite of carbon fiber or glass fiber and resin. The composite material of carbon fiber or glass fiber and resin has high strength and excellent activation resistance. As will be appreciated, other composite materials may be selected. The beam shaper 20 has a partition wall 103 and at least a part of the partition wall 103. The support is provided by the reinforcing portion.

[0040] Continuing to refer to FIGS. 2 to 5, this is Example 1 of the partition wall 103. The partition wall 103 is a side wall. That is, the irradiation chamber 101 and the charged particle beam generation chamber 102 are arranged horizontally, and the partition wall 103 A receiving cavity 1031 is provided in the receiving cavity 1031, and the beam shaper 20 is The receiving cavity 1031 penetrates the partition wall 103 along the thickness direction. In the example, the entire beam shaper 20 is cylindrical, and the receiving cavity 103 accordingly 1 is a circular through hole. The beam shaper is highly sensitive to deformation and requires a sufficient support structure. To ensure rigidity, the bulkhead 103 has reinforcement 1032 in the concrete. The reinforcing portion 1032 is provided between the circular muscle a surrounding the beam shaping body 20 and the frame surrounding the circular muscle a. The framework reinforcement b includes horizontal frame b1 and vertical frame b2, and the horizontal frame b 1 includes horizontal longitudinal reinforcement b11 and ribs b12, and vertical frame b2 includes vertical longitudinal reinforcement b21 and ribs b2 The number of horizontal / vertical reinforcement and ribs is determined according to the actual situation. 32 further includes horizontal and vertical distribution reinforcement c, which is horizontal, vertical and concrete The cleats are distributed throughout the concrete wall at predetermined intervals along the thickness direction. The horizontal and vertical arrangements are determined depending on the situation and are only shown schematically in the figure. The reinforcing bars c pass through the framework bars b, and the horizontal and vertical reinforcing bars c that intersect with the circular reinforcing bars a abut against it. This improves anchor performance and makes it easier to position the anchor during construction. An anchor plate d is provided at the tip of the straight vertical reinforcement b21, and the horizontal vertical reinforcement b11 and the vertical vertical reinforcement b21 are connected. In addition to the distribution reinforcement that contacts the circular reinforcement, distribution reinforcement is only applied to the area other than the framework reinforcement. In this case, if the distribution reinforcement and the framework reinforcement are guaranteed to have a certain contact length, the anchor Plates are not required. The material of the circular reinforcement a and the framework reinforcement b is aluminum magnesium alloy. Or carbon fiber resin composite material or glass fiber resin composite material, and the material of the distribution reinforcement is also aluminum. It is a magnesium alloy, a carbon fiber resin composite, or a glass fiber resin composite, and neutrons As it is generated in the beam shaper, the activation of the surrounding material is of utmost importance and is understandable. In order to reduce costs, the distribution reinforcement should be at least partially (e.g., other than the framework reinforcement). The part (of the reinforcement) may be made of steel, and the quantity of the reinforcement must meet the requirements of the building structure. As those skilled in the art are well aware, during the construction process, In the concrete structure, width stoppers (not shown) may be provided along the thickness direction of the concrete. The quantity of the bars is determined according to the actual situation, and the crossing bars are bound together with fixing parts such as steel wire. Connected, for example, horizontal and vertical distribution reinforcement, horizontal / vertical distribution reinforcement and width stop reinforcement, horizontal / vertical longitudinal reinforcement and Between the ribs, circular reinforcement and horizontal / vertical reinforcement. As you can see, other concrete walls When no beam shapers or other components are attached to W, only the distribution reinforcement may be installed. First, connect the distribution bars of other concrete walls with the distribution bars, circular reinforcement and framework reinforcement of the partition wall 103. Then, the wall edges (including the inner wall of the storage cavity) are formed and the Concrete is poured, and after pouring is complete, the beam shaper is installed in the bulkhead cavity. As can be appreciated, the construction process may be carried out in other ways as would be familiar to one skilled in the art. The compressive load-bearing capacity of the reinforced concrete is high, and the tensile load-bearing capacity of the aluminum magnesium alloy bars and steel bars is high. When aluminum magnesium alloy bars and steel bars are placed in the area subjected to tension, concrete The lack of tensile strength of the concrete can be compensated for, and the placement of stiffening rods improves the shear performance of the wall. The distributed reinforcing bars prevent cracks in the concrete and improve the overall performance of the wall. It is possible.

[0041] As shown in FIGS. 6 to 9, this is Example 2 of the partition wall 103′, and the following points that are different from Example 1 will be described. The reinforcing portion 1032' of the partition wall 103' is a circular member a' surrounding the beam shaper. and a framework member b' surrounding the annular member a', and the framework member b' is a horizontal framework member beam b The reinforcement part 1032' further includes horizontal and vertical distribution reinforcement c ', and horizontal and vertical distribution reinforcement c' are The water is distributed throughout the concrete wall at regular intervals, and the intervals are determined according to the specific circumstances. The flat frame beam b1' and the vertical frame column b2' are connected by bolts and welding. The horizontal and vertical distribution reinforcement c' may be used as long as the strength of the joint is ensured. The air passes through holes pre-installed in the aluminum magnesium alloy framework b' and passes through the The horizontal and vertical distribution reinforcement c' that intersects with the circular member a' is abutted against it. This improves anchor performance and makes it easier to position the anchor during construction. In addition to the distribution reinforcement, distribution reinforcement may be provided only in the area other than the framework shape. The material of the circular ring shape a' and the framework shape b' is aluminum magnesium alloy or is made of carbon fiber resin composite material or glass fiber resin composite material, and the material of the distribution reinforcement is also aluminum. Magnesium alloy, carbon fiber resin composite, or glass fiber resin composite, and neutrons are Since it is generated in the body of the body, activation of the surrounding material is of utmost importance and is understandable. Therefore, in order to reduce costs, the distribution reinforcement should be at least partially (e.g., other than the framework The part (of the reinforcement) may be made of steel, and the quantity of the reinforcement must meet the requirements of the building structure. As those skilled in the art are well aware, during the construction process, In the concrete structure, width stoppers (not shown) may be provided along the thickness direction of the concrete. The quantity of the bars is determined according to the actual situation, and the crossing bars are bound together with fixing parts such as steel wire. Connected, for example, horizontal, vertical distribution reinforcement, horizontal / vertical distribution reinforcement and width stop reinforcement, circular member and horizontal In this embodiment, the cross section of the aluminum magnesium alloy profile The shape is H-shaped, but as can be appreciated, the cross section can be other shapes. Binding the distribution bars of other concrete walls, the distribution bars of partition wall 103', circular members, and framework members After that, the wall edges (including the inner wall of the storage cavity) are formed and concrete is installed. The cleat is poured, and after pouring is complete, the beam former is installed in the bulkhead cavity. As can be appreciated, the construction process may be carried out in other ways as would be familiar to one skilled in the art. Although the compressive strength of the sheet is high, its tensile strength is low and strains over time under normal stress. The tensile strength and shear strength of aluminum magnesium alloy extrusions increase slowly. High strength, high stiffness, and strain does not increase slowly with time under normal stress The distributed reinforcing bars can compensate for the lack of concrete mechanical properties and material properties. This prevents cracks in the concrete and improves the overall performance of the wall.

[0042] As can be seen, the reinforcement of the bulkhead may be a combination of the above two embodiments, e.g. For example, the reinforcement portion may include a circular reinforcement surrounding the beam shaper and a framework member surrounding the circular reinforcement, or Alternatively, it includes a ring-shaped member surrounding the beam shaper and framework reinforcement surrounding the ring-shaped member.

[0043] As shown in FIGS. 10 and 11, the partition wall 103″ is a third embodiment. The irradiation chamber and the charged particle beam generation chamber are arranged vertically, i.e., the partition 103'' is a floor slab (floor plate or ceiling plate), and the neutron generator 10 ″ further The charged particle beam includes a beam transfer section 12'' that transfers the charged particle beam to a target, and the charged particle beam penetrates through a partition wall 103''. A through hole 1031'' is provided, and the beam transfer section 12'' passes through the through hole 1031''. The reinforcing portion 1032'' of the partition wall 103'' includes a first reinforcing portion d and a second reinforcing portion e. The first reinforcement d is provided in the concrete of the bulkhead 103'' and the second reinforcement e is at least The second reinforcement e extends from the concrete of the bulkhead 103'' and is supported by a horizontal support plate e1. and a side plate e2 connecting the support plate e1 and the first reinforcing portion d. The beam shaper 20'' , and is supported by a horizontal support plate e1. In this embodiment, the second reinforcing portion e is a U-shaped groove The side plate e2 has two opposing plates, and the material is aluminum magnesium alloy or is a carbon fiber resin composite or a glass fiber resin composite, which reduces the production of radionuclides, Structural steel has high strength, excellent plasticity and toughness, uniform material quality, and excellent weldability. Considering this, steel may be used and, as can be appreciated, other materials or other types of construction may be used. A flange e11 is provided on the side of the support plate e1 facing the first reinforcing portion d, and The beam shaper 20'' is located within the flange e11, and the flange e11 is In this embodiment, the beam shaping body is cylindrical in shape. Accordingly, the flange is a circular reinforcement. A through hole e12 is further formed in the support plate e1. The neutron beam N generated by the neutron generator 10 passes through a beam shaper 20''. The wire passes through the through hole e12, and in this embodiment, the through hole e12 cuts the support plate e1. It is formed by

[0044] The first reinforcement improves the strength of the edge of the floor slab hole (through hole), while improving beam alignment. The first reinforcing part supports the frame based on the structure of the reinforcing part in the above embodiment. Since this is a floor slab, it is not necessary to use framing reinforcement or framing. The framed section includes only horizontal frame or horizontal framed section beams, and does not include vertical frame or vertical framed section beams. Instead of columns, horizontal frames or horizontal framed beams are used, and the specific structure is not described in detail. Only two profile beams are shown in the figure. When the first reinforcement is configured as a framework profile, , the side plate e2 is welded or bolted to the frame section, and as can be seen, Other connection methods may be used as long as the connection strength is ensured, and the first reinforcing portion serves as a framework reinforcement. When constructed, an anchor plate is provided at the tip of the side plate e2 and anchored to the framework reinforcement. Considering the vertical force on the floor slab and the first reinforcement, The flat framing or horizontal framing beams run the full length of the floor slab. The reinforcement portion 1032'' further includes a (horizontal) distribution bar c'' and a width stop bar (not shown), etc. Reinforcement bars c'' are placed in the concrete at predetermined intervals horizontally and along the thickness of the concrete. During construction, the distribution bars of the other concrete walls and the partition wall 103'' are first distributed. The reinforcement bars / shapes and circular reinforcement bars / shapes are tied together and anchored, and the second reinforcement part is welded to the first reinforcement part. After that, the wall edge (including the inner wall of the through hole) is formed and the After the concrete is poured, the beam shaping body is removed from the side without the side plate of the second reinforcement part. The beam transfer unit is inserted into the flange and attached through the through hole. The construction process may be carried out in other ways as would be familiar to one skilled in the art.

[0045] The boron neutron capture therapy system 100 further includes a preparation room, a control room, and other treatment support rooms. A preparation room can be placed for each irradiation room, including a space for preparing the patient before irradiation treatment. The patient is fixed to the treatment table, the boron drug is injected, and the treatment plan is simulated. A connecting passage is installed between the preparation room and the irradiation room, and preparation work is carried out After completion, the object to be irradiated can be directly pushed into the irradiation chamber, or automatically transferred to the irradiation chamber via a track. The control room controls the accelerator, beam transfer unit, treatment table, etc. The entire irradiation process is controlled and managed by a supervisor in the control room, who simultaneously monitors multiple irradiation rooms. It is possible.

[0046] The concrete wall in this example is made of boron with a thickness of 1 m or more and a density of 3 g / cc. Barite-containing concrete walls, boron-containing concrete has better neutron absorption It has the ability to improve the radiation shielding effect of concrete, and also to As can be appreciated, other thicknesses or densities may be used to reduce the amount of neutron exposure the material receives. The thickness of the concrete wall in different parts may have different degrees or may be replaced by other materials, The density or material may vary. As can be appreciated, the present invention also encompasses other types of neutral It may be applied to a child irradiation system.

[0047] The above description of exemplary specific embodiments of the present invention will help those skilled in the art to understand the present invention. While the present invention is clearly not limited in scope to specific embodiments, it will be readily apparent to those skilled in the art that the present invention is not limited in scope to specific embodiments. It is to be understood that various modifications will be apparent to those skilled in the art without departing from the spirit and spirit of the invention as defined and determined by the appended claims. If within the scope of the present invention, these variations are obvious and therefore fall within the scope of the claims of the present invention. is located.

Claims

1. the neutron generator includes a neutron generator and a beam shaper, the neutron generator including an accelerator and a target, a charged particle beam accelerated by the accelerator interacts with the target to generate a neutron beam, the beam shaper including a reflector, a moderator, a thermal neutron absorber, a radiation shield, and a beam outlet, the moderator moderating neutrons generated by the target to an epithermal neutron energy region, the reflector surrounding the moderator and directing stray neutrons to the moderator to improve the epithermal neutron beam intensity, the thermal neutron absorber absorbing thermal neutrons to avoid excessive doses to superficial normal tissue during treatment, the radiation shield surrounding the beam outlet and provided behind the reflector to shield leaking neutrons and photons to reduce normal tissue dose in non-irradiated regions, and further including a concrete wall, the concrete wall and a reinforcing portion at least a portion of which is provided within the concrete wall supporting the beam shaper, the concrete wall being a floor or ceiling panel; the reinforcing portion includes a first reinforcing portion and a second reinforcing portion, the first reinforcing portion is provided in the concrete of the partition wall and functions as a reinforcing member for the concrete, and the second reinforcing portion at least partially extends from the concrete of the partition wall; A neutron capture therapy system, wherein the second reinforcement section includes a horizontal support plate and a side plate connecting the horizontal support plate and the first reinforcement section, the side plate extending at least partially from the underside of the concrete wall, and the beam shaper being supported by the horizontal support plate.

2. 2. The neutron capture therapy system of claim 1, wherein a flange is provided on the side of the horizontal support plate facing the first reinforcement portion, the beam shaper is positioned within the flange, and the flange horizontally restricts the position of the beam shaper.

3. The neutron capture therapy system of claim 2 , wherein the beam shaper is cylindrical and the flange is an annular reinforcing bar.

4. 2. The neutron capture therapy system according to claim 1, wherein a through-hole is further formed in the horizontal support plate, and the neutron beam generated by the neutron generator passes through the beam shaper and exits from the through-hole.

5. 2. The neutron capture therapy system of claim 1, wherein the neutron generator further includes a beam transfer unit that transfers the charged particle beam generated by the accelerator to the target, a through-hole is provided in the concrete of the partition, and the beam transfer unit passes through the through-hole.

6. 2. The neutron capture therapy system of claim 1, wherein 90% (by weight) or more of the material of the reinforcing portion is composed of at least one element selected from the group consisting of C, H, O, N, Si, Al, Mg, Li, B, Mn, Cu, Zn, S, Ca, and Ti.

7. 2. The neutron capture therapy system of claim 1, wherein the reinforcing portion is made of a material having an elastic modulus of 40 GPa or more, a yield strength of 100 MPa or more, and an ultimate strength of 200 MPa or more, the half-life of a radioactive isotope generated after the reinforcing portion is activated by neutrons is less than one year, and at least a portion of the material of the reinforcing portion is an aluminum alloy, a carbon fiber composite, or a glass fiber composite.

8. 3. The neutron capture therapy system of claim 2, further comprising a charged particle beam generating chamber and an irradiation chamber, wherein the accelerator is housed in the charged particle beam generating chamber, and the concrete wall comprises a partition between the charged particle beam generating chamber and the irradiation chamber.

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