Tablets containing processed goji

Abstract

An object of the present invention is to provide a tablet containing a herbal medicine and having sufficient hardness so that it will not break during packaging, transportation, etc. [Solution] By producing tablets containing a processed plant product other than the processed plant product and in which the processed plant product content is 5 to 80% by weight, it is possible to provide the tablets with sufficient hardness to withstand packaging, transportation, etc.

Description

[Technical Field]

[0001] The present invention relates to a tablet containing a processed plant product. More specifically, the present invention relates to a tablet that contains a processed plant product other than a processed plant product and has sufficient mechanical strength to withstand breakage during packaging, transportation, etc. [Background technology]

[0002] Various physiological functions and pharmacological effects have been reported for herbal medicines depending on their types, and in recent years, they have been widely used in foods, pharmaceuticals, etc. Conventionally, herbal medicines have been formulated into tablets, granules, decoctions, capsules, etc. Among these, tablets are the most accepted formulation form because they have advantages such as ease of administration and masking the bitterness of herbal medicines, and are relatively easy to manufacture.

[0003] After being manufactured, tablets are packaged and transported, but during the packaging and transportation process they are subjected to considerable external forces such as vibration and impact. Therefore, in order to maintain the commercial value of tablets, they must be manufactured to have appropriate mechanical strength (hardness) to prevent breakage.

[0004] Here, tablets containing herbal medicines may contain powdered herbal medicines (crushed herbal medicines) made by powdering the herbal medicines themselves, or may contain powdered herbal medicine extracts made by extracting the active ingredients of the herbal medicines.

[0005] Tablets containing herbal powders contain a large amount of fiber, essential oil components, etc., so even if they are produced by compression molding using the same formulation technology as for other active ingredients, they cannot be hard enough to withstand packaging, transportation, etc., which is a problem.

[0006] Tablets containing herbal extract powder require a larger daily intake of active ingredients (herbal extract powder) than regular pharmaceutical tablets. This results in thicker tablets and a larger number of tablets to be taken per dose, making them difficult for consumers to take. Increasing the content of herbal extract powder in the tablet is an effective way to overcome this drawback, but increasing the content of herbal extract powder in the tablet reduces the content of excipients used relative to the tablet, resulting in a decrease in tablet hardness, making it difficult to withstand packaging, transportation, and other challenges.

[0007] Generally, formulation techniques for increasing tablet hardness include the incorporation of excipients such as lactose and crystalline cellulose, and binders such as hydroxypropyl cellulose and hydroxypropylmethyl cellulose. However, even if such formulation techniques are applied to tablets containing herbal powders or herbal extract powders, there is a problem in that sufficient hardness cannot be obtained.

[0008] Another known formulation method for increasing tablet hardness is to increase the tableting pressure (Non-Patent Document 1). However, even when this formulation method is applied to tablets containing herbal powders or herbal extract powders, sufficient hardness cannot be obtained. Furthermore, applying excessive tableting pressure in an attempt to improve hardness can cause problems such as capping (peeling off the top surface of the tablet) and lamination (layered peeling) during tableting. [Prior art documents] [Non-patent literature]

[0009] [Non-Patent Document 1] Basic Course on Pharmaceutical Development X: Tablet Manufacturing Engineering, Chijin Shokan, 156 pages, 1971 Summary of the Invention [Problem to be solved by the invention]

[0010] An object of the present invention is to provide a tablet containing a herbal medicine and having sufficient hardness so that it will not break during packaging, transportation, etc. [Means for solving the problem]

[0011] The present inventors have conducted extensive research to solve the above-mentioned problems and have found that by blending a processed plant product with a burdock product to produce tablets, the tablets can be provided with a hardness sufficient to withstand packaging, transportation, etc. Furthermore, the inventors have also found that by blending a processed plant product with a burdock product to produce tablets, not only can the hardness be improved but also gloss can be imparted. The present invention was completed through further research based on these findings.

[0012] That is, the present invention provides the following aspects. Item 1. A tablet containing a processed plant product and a processed plant product other than the processed plant product, wherein the content of the processed plant product is 5 to 80% by weight. Item 2. The tablet according to Item 1, wherein the processed plant product is one or more selected from the group consisting of Angelica acutiloba, peony root, Cnidium root, licorice root, cinnamon bark, Panax ginseng, Atractylodes rhizome, Poria cocos, and Peony root. Item 3. The tablet according to Item 1 or 2, which is a direct compression tablet. Item 4. The tablet according to any one of Items 1 to 3, which is an uncoated tablet. Item 5. A product comprising the tablet according to any one of claims 1 to 4 and a pouch or bottle container filled with the tablet. Item 6. A method for improving the hardness of a tablet containing a processed plant product other than a processed gossypium product, comprising: The method for improving hardness comprises blending a processed plant product with a tablet containing a processed plant product other than the processed plant product. Item 7. A method for imparting gloss to a tablet containing a processed plant product other than a processed gossypium product, comprising: The method for imparting glossiness as described above, wherein a processed plant product other than the processed gossanite is blended with the processed plant product. [Effects of the Invention]

[0013] According to the tablet of the present invention, even though it contains herbal medicine, it is possible to improve the hardness and provide it with sufficient hardness to withstand packaging, transportation, etc., and it is also possible to impart gloss to the tablet, thereby providing it with aesthetic appeal that increases the user's visual satisfaction. DETAILED DESCRIPTION OF THE INVENTION

[0014] 1. Tablets containing processed goji The tablet of the present invention is characterized by containing a predetermined amount of a processed plant product other than the processed gossypium product. The tablet of the present invention will be described in detail below.

[0015] Garbage processed products The tablet of the present invention contains a processed gossypium. Gossypium is the root of the plant Achyranthes fauriei Leveille et Vaniot or Achyranthes bidentata Blume, which belongs to the Amaranthaceae family. In the present invention, by blending the processed gossypium with the processed plant product, the tablet hardness can be improved and the tablet can be made glossy.

[0016] Examples of processed goji pulverized materials include the above-mentioned raw material goji pulverized material (goji powder), dried material, solvent extract, etc. From the viewpoint of obtaining a good effect of improving the hardness and imparting gloss to the tablet, the pulverized material (goji powder) is preferred.

[0017] Gossan powder is made by powdering gossan itself. The average particle size of gossan powder is not particularly limited, but from the viewpoint of obtaining a good effect of improving tablet hardness and imparting gloss, it can be, for example, 0.1 to 100 μm, preferably 5 to 80 μm, and more preferably 10 to 80 μm. Here, the average particle size refers to the particle size at 50% of the cumulative value in the particle size distribution determined by laser diffraction / scattering method. The laser diffraction / scattering method is a method for measuring particle size by utilizing the fact that the light intensity distribution of diffracted / scattered light varies depending on the particle size when a laser beam is applied to particles. This method can usually be determined using a laser diffraction particle size distribution analyzer (e.g., the "Laser Particle Size Analyzer SALD-2200" manufactured by Shimadzu Corporation).

[0018] The preparation method for obtaining goshitsu powder is not particularly limited, and for example, a method in which raw goshitsu or dried goshitsu is pulverized using a known pulverizer such as a jet mill can be mentioned.

[0019] The dried goshitsu material is obtained by drying goshitsu itself or processed goshitsu. Examples of processed goshitsu include fermented goshitsu and enzyme-treated goshitsu. The moisture content in the dried product is preferably 10% by weight or less, more preferably 8% by weight or less. The specific form of the dried product is not important, and may be either shredded or pulverized (with an average particle size larger than the above-mentioned goshitsu powder), etc.

[0020] The method for preparing a dried product of goshitsu is not particularly limited, and examples thereof include a method in which goshitsu itself or the above-mentioned processed goshitsu is subjected to a conventionally known drying method such as sun drying, far-infrared radiation, or a dryer (hot air drying, cold air drying, vacuum freeze drying). The goshitsu may be chopped or pulverized before drying, or may be chopped or pulverized after drying. The pulverization method may be similar to the pulverization method used to prepare the above-mentioned goshitsu powder.

[0021] The solvent extract of Gossypium is a component (extract) of Gossypium that is soluble in an extraction solvent. Specific embodiments of the solvent extract of Gossypium include the liquid and dried extract itself, as well as a dried mixture of the extract and an excipient.

[0022] The method for obtaining a solvent extract of Gossypium chinense is not particularly limited, and examples include drying an extract or a concentrate thereof obtained by extracting Gossypium chinense. The extraction solvent used in the extraction process is not particularly limited, and examples include water and organic solvents (alcohols such as ethanol, methanol, isopropanol, propylene glycol, and 1,3-butylene glycol; aqueous alcohols such as aqueous ethanol and aqueous methanol; ether, hexane, benzene, chloroform, acetone, pentane, and ethyl acetate). These extraction solvents may be heated and used as a single solvent or a mixed solvent of any combination of solvents. The extraction conditions are not particularly limited as long as they are generally applicable to plant extraction. For example, 1 to 500 parts by weight, preferably 10 to 200 parts by weight, of water or an organic solvent is added to 1 part by weight of the total weight of the extraction material (calculated as dry weight), and the mixture is stirred at room temperature to about 100°C, preferably about 30 to 70°C, for about 1 to 300 minutes, preferably about 30 to 200 minutes. The obtained extract is filtered to remove solids, concentrated as needed, and then dried. The concentration method is not particularly limited and includes known solvent removal methods such as using an evaporator. The drying method for the extract or its concentrate is not particularly limited and includes known drying methods such as spray drying, vacuum concentration drying, and freeze drying. When the extract is subjected to drying (particularly drying by spray drying), it is desirable to add an excipient to the extract. Adding an excipient in this manner shortens the drying time and also reduces the hygroscopicity after drying. The excipient added during the drying process of the extract is not particularly limited, as long as it is pharmaceutically acceptable, and examples thereof include inorganic excipients such as silicic anhydride, hydrous silicon dioxide, aluminum silicate, magnesium aluminosilicate, magnesium aluminometasilicate, turk, and titanium oxide; celluloses such as cellulose, carboxymethyl cellulose, methyl cellulose, and hydroxypropyl cellulose; starches such as starch and hydroxypropyl starch; dextrin, gelatin, and the like. These excipients may be used alone or in combination of two or more.The amount of excipient added during the drying treatment of the extract (i.e., the amount of excipient contained in the processed goshitsu product) is not particularly limited, but may be, for example, 5 to 70 parts by weight, preferably 20 to 50 parts by weight, of excipient per 100 parts by weight of the dry weight of the extract. Note that the above-mentioned solvent extract may be one that has been subjected to purification procedures such as deodorization and decolorization, as long as the effects derived from the goshitsu raw material are not lost.

[0023] The above-mentioned slag products may be used alone or in combination of two or more.

[0024] The content of the processed plant product in the tablet of the present invention is 5 to 80% by weight. By blending at this ratio, tablets containing the processed plant product described in detail below can be imparted with high tablet hardness and gloss, and their thickness can also be reduced. From the viewpoint of better achieving these effects, the content of the processed plant product is preferably 8 to 80% by weight, more preferably 10 to 80% by weight. Furthermore, from the viewpoint of the hardness improvement effect per content of the processed plant product and the rate of increase in gloss imparted, the content is more preferably 10 to 70% by weight, and particularly preferably 10 to 60% by weight. Note that when the processed plant product contains an excipient, the content of the processed plant product described above is a value calculated excluding the content of the excipient.

[0025] In the tablets of the present invention, the blending ratio of the gossip processed product to the other plant processed products is not particularly limited, but from the viewpoint of obtaining a better hardness-improving effect and gloss-imparting effect, the gossip processed product may be 0.1 to 15 parts by weight, preferably 0.15 to 4 parts by weight, more preferably 0.15 to 2.5 parts by weight, per 1 part by weight of the plant processed product.

[0026] Plant processed products other than processed goshitsu products The tablet of the present invention contains a processed plant product other than goshitsu. The processed plant product may be a pulverized product (crude herb powder), dried product, solvent extract, etc., of the raw plant (other than goshitsu). From the viewpoint of obtaining the tablet hardness-improving effect and gloss-imparting effect of the processed goshitsu, a pulverized product (crude herb powder) is preferable. Specific embodiments and preparation methods of these processed plant products are the same as those of the processed goshitsu described above, except that the following plants are used as raw materials.

[0027] The plant used as the raw material for the plant processed product is not particularly limited as long as it is a plant other than Achyranthes gracilis, a plant of the Amaranthaceae family, which is the raw material for Goshitsu. For example, a person skilled in the art can appropriately select the plant depending on the physiological function and pharmacological effect to be imparted to the tablet. Specific examples of such plants include ginseng (Panax Ginseng), Panax pseudo-ginseng, ginseng (Panax quinquefolium Linne), Cistanche Tubulosa (Cistanche Tubulosa), Plantago Ovata Forsk, ephedra (Ephedra sinica Stapf, Ephedra intermedia Schrenk et CA Meyer, Ephedra equisetina Bunge), rhubarb (Rheum palmatum Linne, Rheum tanguticum Maximowicz, Rheum officinable Baillon, Rheum coreanum Nakai, or interspecific hybrids thereof), licorice (Glycyrrhiza uralensis Fischer, Glycyrrhiza glabra Linne), ephedra (Ephedra sinica Stapf, Ephedra intermedia Schrenk et CA Meyer, Ephedra equisetina Bunge), peony (Paeonia lactiflora Pallas), Scutellariae baicalensis Georgi, ginger (Zingiber officinale Roscoe), Japanese holly (Schizonepeta tenuifolia Briquet), forsythia (Forsythia suspense Vahl, Forsythia viridissima Lindley), Japanese angelica (Angelica acutiloba Kitagawa, Angelica acutiloba Kitagawa var. sugiyamae Hikino), Cnidium officinale Makino, Japanese holly (Gardenia jasminoides Ellis), mint (Mentha arvensis Linne var.piperascens Malinvaud), Saposhnikovia divaricata Schischkin, Sandalwood (Atractylodes japonica Koidzumi ex Kitamura, Atractylodes ovata De Candolle), Bellflower (Platycodon grandiflorum A. De Candolle), Saiko (Bupleurum falcatum Linne), Hange (Pinellia ternata) Breitenbach), Zizypus jujube (Miller var. Examples of suitable plants include Atractylodes lancea De Candolle, Atractylodeschinensis Koidzumi, Paeonia suffruticosa Andrews, Paeonia moutan Sims, Cinnamon bark (Cinnamomum cassis Blume), and Poria cocos Wolf. These plants may be used singly or in combination of two or more. To obtain better hardness-improving and gloss-imparting effects in the tablet of the present invention, preferred plants include one or more selected from the group consisting of Angelica acutiloba, Peony root, Cnidium officinale, Peony bark, Panax ginseng, Licorice root, Cinnamon bark, Atractylodes rhizome, and Poria cocos.

[0028] In the present invention, the part of the plant used as the raw material for the plant processed product is not particularly limited as long as the effects of the present invention are achieved, and can be appropriately selected by a person skilled in the art depending on the type of plant. Examples of the part of the plant that can be used as the raw material for the plant processed product include the whole plant, rhizome, leaves, roots, and fruit.

[0029] The content of the processed plant products other than the gossip product in the tablet of the present invention is not particularly limited as long as the effects of the present invention are exhibited, but the total amount is usually about 0.1 to 90 wt%, preferably about 10 to 90 wt%, more preferably about 20 to 80 wt%, even more preferably about 30 to 80 wt%, and particularly preferably about 40 to 80 wt%. Since the hardness of the tablet of the present invention is improved by the incorporation of the gossip product, it can have sufficient mechanical strength even if it contains a high content of processed plant products other than the gossip product.

[0030] Other ingredients In addition to the processed gossypium and processed plant products other than the processed gossypium, the tablet of the present invention may contain other nutritional components or pharmacological components depending on its intended use. Such nutritional components and pharmacological components are not particularly limited as long as they are usable in foods and pharmaceuticals, but examples include antacids, stomachic agents, digestive aids, intestinal regulators, antispasmodics, mucosal repair agents, anti-inflammatory agents, astringents, antiemetics, antitussives, expectorants, anti-inflammatory enzymes, sedatives, hypnotics, antihistamines, caffeine, cardiac diuretics, antibacterial agents, vasoconstrictors, vasodilators, local anesthetics, herbal extract powders, vitamins, and menthols. These nutritional components and pharmacological components may be used alone or in combination of two or more. The content of these components can be appropriately determined by those skilled in the art depending on the type of components used.

[0031] Furthermore, in addition to the processed gossypium and processed plant products other than the processed gossypium, the tablet of the present invention may contain other additives required for formulation into tablets, as necessary. Such additives are not particularly limited as long as they are usable in foods and pharmaceuticals, but examples include water, excipients (other than the excipients contained in the processed gossypium and processed plant products), binders, lubricants, disintegrants, antioxidants, preservatives, flavorings, flavoring agents, thickeners, pigments, pH adjusters, buffers, chelating agents, etc. These additives may be used alone or in combination of two or more. The content of these additives is appropriately determined depending on the type of additive used, etc.

[0032] Formulation properties The tablet of the present invention can have an appropriate hardness that prevents breakage during packaging, transportation, etc. The hardness of the tablet of the present invention may be such that it does not break during packaging, transportation, etc., and specifically is 170 N or more, more preferably 180 N or more, and even more preferably 190 N or more. The hardness of the tablet of the present invention is measured using a load cell type tablet hardness tester.

[0033] The tablet of the present invention further has glossiness, which can be determined by visually inspecting the surface of the tablet.

[0034] Formulation The tablets of the present invention may be direct-compressed tablets without prior granulation, since the hardness is increased by the incorporation of the gossip-processed product. Furthermore, the tablets of the present invention may be plain tablets without a coating (e.g., a glossing agent, a sugar-coating base, a water-soluble coating base such as gelatin, an enteric coating base, a film-coating base, etc.), since the glossiness is imparted by the incorporation of the gossip-processed product. Of course, this does not exclude the tablets of the present invention from being coated tablets with such a coating, and in this case, from being two-layer or more multi-layer tablets.

[0035] The size of the tablets of the present invention is not particularly limited as long as the effects of the present invention are achieved, and can be appropriately determined by those skilled in the art depending on, for example, the intended recipient and purpose of administration. For example, the diameter of the tablets of the present invention is exemplified as a size that is easy to ingest, preferably 18 mm or less, more preferably 15 mm or less, and even more preferably 12 mm or less. Because the hardness of the tablets of the present invention is increased by the incorporation of processed gossypium, the amount of additives added to increase tablet hardness, such as excipients and binders, relative to the content of the herbal ingredients can be reduced. Therefore, the tablets of the present invention can be manufactured with an even smaller diameter than the above, preferably 10 mm or less, more preferably 9 mm or less, and even more preferably 8 mm or less. Similarly, the thickness of the tablets (thickest part) can also be reduced, preferably 4.45 mm or less, and even more preferably 4.43 mm or less. Furthermore, the weight per tablet of the present invention is similarly preferably 180 to 400 mg, more preferably 250 to 350 mg.

[0036] The packaging form of the tablets of the present invention is not particularly limited, and examples thereof include individual packaging in PTP packages and non-individually packaged in pouch containers or bottle containers. Because the hardness of the tablets of the present invention is increased by the incorporation of a barbed wire, it is more preferable that they be provided as non-individually packaged products filled in pouch containers or bottle containers. In addition, the material of the bottle container in such products is not particularly limited, and may be any of glass, metal, and resin.

[0037] Formulation Method The method for producing the tablets of the present invention is not particularly limited as long as the tablets obtained can exhibit the desired effects, and can be produced according to a conventionally known method. Usually, the processed gossypium spp., the processed plant product, and optionally other excipients are mixed and compressed into tablets.

[0038] When a liquid substance is used as the processed goshitsu product or processed plant product, it is used in an amount such that the dry weight of the liquid substance will be the above-mentioned content (i.e., 5 to 80% by weight for the processed goshitsu product, 0.1 to 90% by weight for the processed plant product, etc.). When a processed goshitsu product or processed plant product containing an excipient is used, it is used in an amount such that the weight excluding the excipient will be the above-mentioned content.

[0039] In tableting, a mixture containing all of the ingredients to be blended may be tableted (direct tableting) without prior granulation, or some or all of the ingredients to be blended may be granulated into granules or other granular tablets before tableting. In the present invention, since the hardness of the tablet is increased by blending the bark processed material, tablets with good mechanical properties can be obtained even by direct tableting without prior granulation.

[0040] As the tableting machine, a single punch tableting machine, a rotary tableting machine, a high-speed rotary tableting machine, etc. can be used. The tableting pressure during tableting is not particularly limited as long as it is possible to form tablets, but is, for example, 250 to 4000 kg / cm. 2 Examples include:

[0041] Intake The daily intake amount of the tablet of the present invention can be changed as appropriate depending on the subject of administration and the type of blended herbal medicine, but for example, the daily dose for an adult (body weight 60 kg) is usually about 0.01 to 12 g, preferably about 0.05 to 10 g, more preferably about 0.07 to 8 g, in terms of the total amount of the Gossypium processed product and the processed plant product. The tablet of the present invention is usually used in an oral administration form, divided into 2 to 3 doses per day.

[0042] 2. Methods for improving tablet hardness and adding gloss to tablets The present invention provides a method for improving tablet hardness. Specifically, the method for improving tablet hardness is characterized by blending a gossanite product with a tablet containing a plant processed product other than the gossanite product. The types and amounts of ingredients used in the method for improving hardness, the tablet molding method, etc. are as described in the above section "1. Tablets containing a gossanite product."

[0043] The present invention also provides a method for imparting gloss to a tablet. Specifically, the method for imparting gloss to a tablet is characterized by blending a gossan-processed product with a tablet containing a plant processed product other than the gossan-processed product. In the method for imparting gloss, the types and amounts of ingredients used, the tablet molding method, etc. are as described in the above section "1. Tablets containing a gossan-processed product." [Example]

[0044] The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

[0045] Test Example 1 1. Tablet manufacturing 1-1. Preparation of the waste The scouring powder was prepared as follows. The "dried scouring powder" (shredded material) was coarsely pulverized for 1 minute using a sample mill SK-M 10R (Kyoritsu Riko Co., Ltd.) at 10 revolutions per minute, then sieved through a 500 μm mesh, and further pulverized at 16,000 rpm using an SP-2 benchtop pulverizer (Sakai Co., Ltd.) to obtain scouring powder. The average particle size of the resulting scouring powder was 40 μm.

[0046] 1-2. Tablet manufacturing Tablets were manufactured with the composition shown in Table 1. Specifically, all of the components shown in Table 1 were mixed in the indicated ratios, and the resulting mixed powder was compressed in a tablet press at a compression force of 10 kN to obtain convex tablets (disk-shaped, 8 mm diameter) weighing 200 mg each.

[0047] 2. Tablet evaluation 2-1.Hardness For each tablet of Comparative Example 1 and Examples 1 to 9, the hardness in the horizontal direction relative to the tablet was measured using a load cell tablet hardness tester (PC-30, manufactured by Okada Seiko Co., Ltd.). The vertical direction is the direction in which pressure and compression are applied with the pestle during tableting, and the horizontal direction is the direction perpendicular to the vertical direction. The hardness of each of 10 tablets was measured, and the average value of these measurements was used to calculate the hardness.

[0048] 2-2. Glossiness Ten monitors were asked to evaluate the degree of glossiness of each tablet of Comparative Example 1 and Examples 1 to 9. The glossiness was scored using a visual analog scale (VAS), with a glossiness of "10" indicating that the tablet surface was clearly glossy, and a glossiness of "1" indicating that no glossiness was observed. The average glossiness scores judged by the 10 monitors were calculated (rounded to one decimal place).

[0049] 2-3. Thickness The thickness of the tablets of Comparative Example 1, Example 3, Example 6, Example 7 and Example 9 was measured using a digital outside micrometer 211-101E (manufactured by MonotaRo Co., Ltd.).

[0050] 3.Results The results are shown in Tables 1 and 2. The tablet containing only Angelica acutiloba powder without Gossan powder (Comparative Example 1) had low tablet hardness and no gloss, but the tablets containing Gossan powder together with Angelica acutiloba powder (Examples 1 to 9) had improved tablet hardness and gloss. Furthermore, the tablets containing Gossan powder and Angelica acutiloba powder (Examples 3, 6, 7, and 9) were thinner than the tablet containing only Angelica acutiloba powder (Comparative Example 1), and were therefore easier to take.

[0051] [Table 1]

[0052] [Table 2]

[0053] Test Example 2 Tablets were prepared in the same manner as in Comparative Example 1 and Examples 2, 5, 6 and 8, except that peony root powder, Cnidium root powder, licorice root powder, cinnamon bark powder, carrot powder, Atractylodes Root powder, Poria cocos powder or Peony root powder was used instead of Angelica acutiloba powder. It was confirmed that regardless of which herbal powder was used, the tablets prepared in the same manner as in Examples 2, 5, 6 and 8 had improved tablet hardness and were imparted with gloss, and were thinner than the tablets prepared in the same manner as in Comparative Example 1.

[0054] Prescription example Tablets were prepared with the compositions shown in Table 3. As in the above Examples, all of these tablets were excellent in tablet hardness and gloss, and were thin and easy to take.

[0055] [Table 3]

Claims

1. A tablet containing powdered goji rhizome and one or more processed plant products selected from the group consisting of Angelica acutiloba, Peony root, and Cnidium officinale, wherein the content of said powdered goji rhizome is 5 to 80% by weight, and the content of said powdered goji rhizome is 56 / 24 parts by weight or more per part by weight of said processed plant product.

2. 2. The tablet of claim 1 which is a direct compression tablet.

3. The tablet according to claim 1 or 2, which is an uncoated tablet.

4. A product comprising the tablet according to any one of claims 1 to 3 and a pouch or bottle container filled with said tablet.

5. 1. A method for improving the hardness of a tablet containing one or more processed plant products selected from the group consisting of Angelica acutiloba, Peony root, and Cnidium root, The method for improving hardness comprises blending powdered goji husk with a tablet containing the processed plant product in an amount of 56 / 24 parts by weight or more of powdered goji husk per part by weight of the processed plant product.

6. 1. A method for imparting gloss to a tablet containing one or more plant processed products selected from the group consisting of Angelica acutiloba, Peony root, and Cnidium root, comprising: The method for imparting glossiness comprises blending powdered goji husk with the tablet containing the processed plant product in an amount of 56 / 24 parts by weight or more per part by weight of the processed plant product.

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