Biosignal Measurement System

Abstract

A biosignal measurement system (10) of the present invention comprises a plurality of electrode devices (20, 30) and a biosignal generation device (40). Each of the plurality of electrode devices (20, 30) includes an electrode (21, 31) that measures biopotential, an amplification circuit (22, 32) that amplifies the measured biopotential, a quantization circuit (23, 33) that converts the amplified biopotential into digital data to generate biopotential information, and a wireless transmitter (24, 34) that transmits the biopotential information. The biosignal generation device (40) uses the biopotential information transmitted from the electrode devices (20, 30) to generate biosignal waveforms and reference electronic information. The electrode devices use the reference potential information received from the biosignal generation device (40) to amplify the biopotential. This makes it possible to eliminate discomfort and restraint on a body of a wearer of the electrode device during wearing and take natural measurements of biosignals.

Description

[Technical Field]

[0001] The present invention relates to a biosignal measurement system for measuring biosignals such as electrocardiogram waveforms. [Background technology]

[0002] In recent years, one of the methods for managing personal health is to record biosignals such as electrocardiogram waveforms over a long period of time and analyze the characteristics and changes of the waveforms to detect the activity of the autonomic nervous system and early signs of heart disease.As a method for acquiring biosignals such as electrocardiogram waveforms over a long period of time, wearable electrodes in which bioelectrodes are attached to clothing have been proposed (see, for example, Non-Patent Document 1).

[0003] An electrocardiogram, which is one type of biosignal, requires measuring the potential difference between electrodes placed on both the left and right sides of the heart. As shown in Figure 8, the wearable electrode 100 in Non-Patent Document 1 has a device 400 that measures bioelectric potentials worn around the center of the torso, and electrodes (200, 300) that are wired over compression wear and come into contact with the left and right waist regions. [Prior art documents] [Non-patent literature]

[0004] [Non-Patent Document 1] Naoko Kasai, Takayuki Ogasawara, Hiroshi Nakajima, Shingo Tsukada, "Development and Practical Application of Hitoe, a Functional Material that Enables Biometric Measurement Simply by Wearing It," IEICE Communications Society Magazine, Vol. 11, No. 1, pp. 17-23, Published June 1, 2017 Summary of the Invention [Problem to be solved by the invention]

[0005] When bioelectrodes are attached to the torso through clothing, the effort required for attachment can be irritating to the wearer, and the pressure of the clothing can be uncomfortable for the wearer. When electrodes are attached to a location other than the torso, for example, to the limbs, the wiring connecting the left and right electrodes forms a loop like handcuffs, which restricts the wearer's physical movement and creates a strong constraint.

[0006] The object of the present invention is to solve the above-mentioned problems and to provide a biosignal measurement system that can measure biosignals naturally by eliminating the discomfort and physical constraints that the wearer feels when wearing an electrode device. [Means for solving the problem]

[0007] In order to solve the above problem, the biosignal measurement system of the present invention comprises: electrodes for measuring biopotentials; an amplifier circuit for amplifying the measured biopotentials; a quantization circuit for converting the amplified biopotentials into digital data to generate biopotential information; a plurality of electrode devices each having a wireless transmitter for transmitting the biopotential information; a wireless receiver for receiving reference potential information from the amplifier circuit; and a power source for supplying power to the amplifier circuit, the quantization circuit, the wireless transmitter, and the wireless receiver; a biosignal generating device having a wireless receiver for receiving the biopotential information transmitted from the wireless transmitters of the electrode devices; an arithmetic circuit for generating a biosignal waveform and the reference potential information using the biopotential information from at least two electrode devices of the plurality of electrode devices; and a wireless transmitter for transmitting the generated reference potential information to the electrode device; and the amplifier circuit of the electrode device amplifies the biopotential using the reference potential information received from the biosignal generating device. [Effects of the Invention]

[0008] According to the present invention, it is possible to provide a biosignal measurement system that can measure biosignals naturally by eliminating the discomfort and physical constraints that the wearer feels when wearing an electrode device. [Brief explanation of the drawings]

[0009] [Figure 1] FIG. 1 is a diagram showing an example of the configuration of a biological signal measurement system according to a first embodiment of the present invention. [Figure 2] FIG. 2 is a conceptual diagram of a biological signal measurement system according to an embodiment of the present invention. [Figure 3] FIG. 3 shows an example of a measurement circuit used in a conventional biosignal measurement system. [Figure 4] FIG. 4 is a diagram showing an example of the configuration of a biological signal measurement system according to the second embodiment of the present invention. [Figure 5] FIG. 5 is a diagram showing an example of the configuration of a biological signal measurement system according to the third embodiment of the present invention. [Figure 6] FIG. 6 is a diagram showing an example of an operation flow in the reference potential correction circuit according to the third embodiment of the present invention. [Figure 7] FIG. 7 is a diagram showing an example of the configuration of a reference potential correction circuit according to the fourth embodiment of the present invention. [Figure 8] FIG. 8 shows an example of the configuration of a conventional biosignal measurement system. DETAILED DESCRIPTION OF THE INVENTION

[0010] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The following describes embodiments of the present invention with reference to the accompanying drawings. However, the present invention is not limited to the following embodiments.

[0011] First Embodiment 1 is a diagram showing an example of the configuration of a biosignal measurement system according to a first embodiment of the present invention. The biosignal measurement system 10 of this embodiment includes a plurality of electrode devices (20, 30) that measure biopotentials, and a biosignal generating device 40 that generates a biosignal waveform using biopotential information from the plurality of electrode devices (20, 30).

[0012] The electrode device (20, 30) has electrodes (21, 31) that measure a biopotential, amplifier circuits (22, 32) that amplify the measured biopotential, quantization circuits (23, 33) that convert the amplified biopotential into digital data to generate biopotential information, wireless transmitters (24, 34) that transmit the biopotential information, wireless receivers (26, 36) that receive reference potential information from a biosignal generating device 40, and power supplies (25, 35) that supply power to the amplifier circuits (22, 32), quantization circuits (23, 33), wireless transmitters (24, 34), and wireless receivers (26, 36). The amplifier circuits (22, 32) amplify the biopotential using the reference potential information received from the biosignal generating device 40.

[0013] The biosignal generating device 40 has a wireless receiver 41 that receives biopotential information transmitted from wireless transmitters (24, 34) of the electrode devices (20, 30), an arithmetic circuit 42 that generates a biosignal waveform and reference potential information in an amplifier circuit (22, 32) using biopotential information from at least two of the multiple electrode devices (20, 30), and a wireless transmitter 44 that transmits the generated reference potential information to the electrode devices (20, 30).

[0014] A conceptual diagram of a biosignal measurement system 10 according to this embodiment is shown in FIG. 2. For example, when generating an electrocardiogram as a biosignal, it is necessary to arrange multiple electrode devices (20, 30) in positions that sandwich the heart. A possible way to wear the electrode devices (20, 30) that is comfortable for the wearer 1 is to wear the electrode devices (20, 30) on the four limbs, such as the hands and feet. By adopting such a wearing style of the electrode devices (20, 30), it is possible to significantly reduce the feeling of pressure and discomfort caused by wearing clothing, etc.

[0015] Each electrode device (20, 30) measures an in-phase component that appears as a noise component and an out-of-phase component that appears as a biopotential. The biopotential signals that can be measured by the electrodes (21, 31) of each electrode device (20, 30) are weak and have an extremely poor signal-to-noise ratio.

[0016] In the biosignal measurement system 10 according to this embodiment, a plurality of measured biopotential signals are transmitted to the biosignal generation device 40 via wireless communication, and a difference calculation is performed on the biopotential signals in the biosignal generation device 40. By performing the difference calculation, it is possible to generate a biosignal by removing in-phase components that appear as noise components, thereby improving the S / N ratio.

[0017] In the biosignal measurement system of this embodiment, the transmission of biopotential information from multiple electrode devices that measure biopotentials to a biosignal generating device that generates biosignal waveforms is performed using wireless communication, thereby providing a biosignal measurement system that can measure biosignals naturally, eliminating the discomfort and physical constraints on the wearer caused by physical wiring when wearing electrode devices.

[0018] 2 illustrates the case where an electrocardiogram, which is one type of biosignal, is measured, but the biosignal measurement system of this embodiment is not limited to electrocardiogram measurement and can also be applied to measurement of other biosignals such as electromyograms and electroencephalograms. By applying the biosignal measurement system of this embodiment, it is possible to eliminate discomfort felt by the wearer due to the physical wiring of the electrode device, and it is also expected to have the effect of increasing the degree of freedom in electrode placement and broadening the range of gadgets that can be implemented.

[0019] The electrodes (21, 31) of the electrode devices (20, 30) can be made of various materials and have various configurations, including Ag / AgCl electrodes used in medical applications, conductive cloth electrodes, and metal electrodes.

[0020] In addition, usability can be further improved by using a non-contact electrode configuration in which electrodes are worn over clothing using cloth or metal electrodes that do not need to be directly attached to the wearer's body.

[0021] Since biopotential information is a very weak signal, it requires signal amplification using a filter circuit and an operational amplifier (22, 32). The amplifier circuits (22, 32) of the electrode devices (20, 30) require high input impedance to reduce loss of biopotential.

[0022] In an inverting amplifier circuit, the resistor that determines the input impedance also affects the gain setting and contributes directly to thermal noise, reducing the signal-to-noise ratio of the biopotential. On the other hand, a non-inverting amplifier circuit has the advantage that noise is less likely to increase even when configured with a high input impedance. It is effective to use a non-inverting amplifier circuit as the amplifier circuit (22, 32). By adopting a non-inverting amplifier circuit, it is possible to achieve a configuration equivalent to that of an instrumentation amplifier, which has a high ability to suppress common-mode components that appear as noise components in the system.

[0023] Any wireless standard can be used in the wireless transmitters (24, 34) of the electrode devices (20, 30), such as carrier communication, Wi-Fi (registered trademark), or Bluetooth (registered trademark). The biosignal generating device 40 that receives the biopotential information transmitted by the electrode devices (20, 30) can be selected according to the communication standard being used. When a short-range communication standard such as Bluetooth is used, a device carried by the wearer, such as a smartphone, can be used, and when a short-range communication standard such as Wi-Fi is used, a device such as a server can also be used.

[0024] In this embodiment, usability is improved by using multiple electrode devices (20, 30) without physical wiring. However, since the electrode devices (20, 30) are not connected by physical wiring, a problem occurs in that the reference potentials in the amplifier circuits of each electrode device do not match. An instrumentation amplifier, as shown in Figure 3, is a measurement circuit commonly used in conventional systems with physical wiring.

[0025] In biosignal measurement, to detect the potential difference between biopotentials measured by multiple electrodes, it is necessary to amplify the difference between the two input potentials input to the input terminals of the differential amplifier circuit downstream of the instrumentation amplifier in Figure 4 while significantly suppressing the common-mode noise component input to the input terminals.To suppress this common-mode noise component, it is important that the inverting input terminals of the two non-inverting amplifier circuits in the amplification stage upstream of the instrumentation amplifier in Figure 3 are connected to each other, in other words, that the reference potential of the two non-inverting amplifier circuits is shared.

[0026] The potential at the connection point of the inverting input terminals of these two non-inverting amplifier circuits converges to the average of the two input potentials and becomes the reference potential of the two non-inverting amplifier circuits. In Figure 1, there is no physical wiring between the electrode devices (20, 30), and the inverting input terminals of the amplifier circuits (22, 32) of the electrode devices (20, 30) are not connected by physical wiring. As a result, the reference potentials of the amplifier circuits (22, 32) of each electrode device (20, 30) may not match, which may result in a deterioration of measurement accuracy.

[0027] In this embodiment, in order to improve the deterioration of measurement accuracy due to mismatch in reference potentials, the reference potential of the two separated non-inverting amplifier circuits is made common. Specifically, the reference potential is made common by using the reference potential generated by the biosignal generating device 40 as the reference potential of the amplifier circuits (22, 32) in each electrode device (20, 30). This enables signal amplification with a common reference potential of the amplifier circuits (22, 32) between the multiple electrode devices (20, 30), improves the measurement accuracy of the biosignal, and ultimately enables the acquisition of a good biosignal.

[0028] The electrode devices (20, 30) of this embodiment are equipped with wireless receivers (26, 36) for receiving reference potential information from the biosignal generating device 40. The amplifier circuits (22, 32) of each electrode device (20, 30) amplify the biopotential by using, as a reference potential, a potential obtained by converting the reference potential information received as a digital value into an analog value.

[0029] A digital-to-analog converter (DAC) can be used to convert digital values ​​to analog values. Some electronic devices, such as audio equipment, have a low-pass filter at the output of the DAC, and using a similar configuration can suppress unstable oscillations in the amplifier circuit.

[0030] The arithmetic circuit 42 of the biosignal generating device 40 uses information on the biopotential measured by the multiple electrode devices (20, 30) to generate a reference potential when amplifying the biopotential in the electrode devices (20, 30). For example, the arithmetic circuit 42 of the biosignal generating device 40 may generate the reference potential by using an arithmetic average of information on the biopotential measured by the multiple electrode devices (20, 30).

[0031] Since a communication module typically has both transmitting and receiving functions, the wireless transmitters (24, 34) and wireless receivers (26, 36) in Fig. 1 may be implemented in a single communication module. As long as it is possible to send the digitized biopotential information output from the quantization circuits (23, 33) to the biosignal generating device 40 and receive the reference potential information obtained by calculating the biopotential information from the biosignal generating device 40, the configuration is not limited to that of Fig. 1 and other configurations may be used.

[0032] One type of biosignal is the electrocardiogram, known as the 12-lead electrocardiogram, which is used for medical purposes. When measuring a 12-lead electrocardiogram, 10 electrodes are attached to the limbs and around the ribs, and the potential difference between multiple electrode pairs is measured. With this type of electrode arrangement, numerous cables get tangled around the wearer's body, causing significant discomfort to the wearer, so measurements are rarely taken in positions other than the recumbent position.

[0033] By applying the biosignal measurement system of this embodiment as a system for generating a 12-lead electrocardiogram, it is possible to eliminate all of the numerous cables mentioned above. This eliminates the discomfort felt by the wearer due to the numerous cables, and also makes it possible to perform 12-lead electrocardiogram measurement at any time in daily life, which is expected to contribute to the advancement of medical care.

[0034] <Second embodiment> 4 is a diagram showing an example of the configuration of a biosignal measurement system according to a second embodiment of the present invention. The function required of the biosignal generating device is to receive biopotential information transmitted from multiple electrode devices and generate a biosignal and reference potential information using the received biopotential information. As in the configuration example of FIG. 4, the function of the biosignal generating device 40 may be implemented in any of the electrode devices 30.

[0035] In the following explanation, the electrode device 30 that implements the functions of the biological signal generating device 40 is referred to as the parent device, and the electrode device 20 that transmits a signal of the measured potential to the parent device is referred to as the child device, and the operation of this embodiment is explained.

[0036] A wireless receiver 41 of the parent device receives information on the biopotential measured by the child device, and an arithmetic circuit 42 of the parent device generates a biosignal and reference potential information using the information on the biopotential measured by the parent device and the information on the biopotential measured by the child device. The generated biosignal is stored in a memory 43 of the parent device and can be used when analyzing the biosignal, thereby realizing the same functions as the biosignal generating device 40 of the first embodiment.

[0037] The reference potential information generated in the parent device is used as a reference potential in the amplifier circuit 32 of the parent device and is also transmitted to the child device via a wireless transmitter 44. The amplifier circuit 22 of the child device amplifies the biopotential using the reference potential that has been converted into analog data from the reference potential information received from the parent device. In this embodiment, there is no need for a biosignal generating device 40 as a device separate from the electrode device, so there is no need to carry a device such as a smartphone, and biosignal measurement can be realized with less restrictions on the user.

[0038] <Third embodiment> According to the first and second embodiments, it is possible to measure biosignals with the same accuracy as conventional biosignal measurement systems using multiple electrode devices without physical wiring. However, there is a problem in that delays occur when biopotential information and reference potential information are transmitted between the biosignal generating device 40 and the electrode devices (20, 30) via wireless communication including digital logic. The amount of delay varies depending on the communication protocol, but for example, with Bluetooth, it is about 10 msec.

[0039] In conventional biosignal measurement systems with physical wiring, delay can be considered to be almost zero. On the other hand, in this embodiment, if the delay due to wireless transmission is large, the effect may not be negligible. Since the reference potential is generated by adding two pieces of biopotential information, the differential mode component, which is a signal component, is suppressed, and only the common mode (in-phase) component, which is a noise component, remains.

[0040] When the amplifier circuit of the electrode device is a non-inverting amplifier circuit, the output voltage Vo is expressed by the following equation (1): S(t) and C(t) are the signal component and the common mode component, respectively, and have periodicity.

number

[0041] According to the above formula (1), if there is a delay that inverts the phase of the common-mode component, the common-mode component will not be suppressed but will instead be emphasized, which may cause output saturation or oscillation in the amplifier circuit, making it impossible to measure biopotentials.

[0042] To solve this problem, in a third embodiment, the phase fluctuation of the reference potential information caused by the propagation delay is corrected using the time-series data of the stored reference potential information. Fig. 5 is a diagram showing an example of the configuration of a biosignal measurement system according to a third embodiment of the present invention. In this embodiment, as shown in Fig. 5, a reference potential correction circuit (27, 37) is provided in each electrode device (20, 30), a certain amount of time-series data of the received reference potential information is stored, and a correlation value of the stored time-series data of the reference potential information is calculated to estimate the lag in the time-series data of the reference potential information, and the phase fluctuation of the reference potential information is corrected based on the estimated lag.

[0043] FIG. 6 is a diagram showing an example of an operation flow of a reference potential correction circuit according to a third embodiment of the present invention. In this embodiment, a predetermined amount of time-series data of reference potential information is saved (S1-1 to S1-3), a correlation value of the saved data of reference potential information is calculated (S1-4), a lag, which is the amount of delay in the time-series data of reference potential information, is estimated using the calculated correlation value (S1-5), and phase fluctuations of the reference potential information are corrected according to the estimated lag value (S1-6). By correcting the phase of the reference potential information according to the lag value estimated using the correlation value, phase fluctuations caused by propagation delays are corrected, enabling biopotential measurement with reduced saturation and oscillation. A ring buffer may be used to save the time-series data of reference potential information. Using a ring buffer allows for efficient memory allocation.

[0044] <Fourth embodiment> 7 is a diagram showing an example of the configuration of a reference potential correction circuit according to a fourth embodiment of the present invention. In the reference potential correction circuit 50 of this embodiment, reference potential information received from a biosignal generating device is converted into an analog signal, and then the reference potential information is compared in phase with a biopotential signal input from an electrode unit, and the phase of the reference potential is corrected according to the obtained phase difference. By correcting the phase in the analog domain, there is no need to perform digital calculations as in the third embodiment, and power consumption can be significantly reduced.

[0045] The reference potential correction circuit 50 of this embodiment can be realized, for example, as shown in FIG. 7, by a phase comparator 51, an LPF (Low-Pass Filter) 52, a VCO (Voltage-controlled oscillator) 53, an AM modulator 54, an APF (All-Pass Filter) 55, and an AM demodulator 56.

[0046] In this embodiment, a signal having a frequency corresponding to the phase difference between the biopotential signal and the reference potential signal is output using a phase comparator 51 that compares the phases of the biopotential signal and the reference potential signal, an LPF 52 that outputs a DC component from the output of the phase comparator 51, and a VCO 53 that is an oscillator that outputs a signal having a frequency corresponding to the output of the LPF 52. In an AM modulator 54, the reference potential signal is amplitude-modulated by the output signal of this VCO 53, and the amplitude-modulated reference potential signal is passed through an APF 55.

[0047] The APF 55 changes only the phase of the reference potential signal without changing its amplitude, so by passing the reference potential signal amplitude-modulated using the output signal of the VCO 53 through the APF 55, it is possible to shift the phase of the reference potential signal in accordance with the frequency of the output signal of the VCO 53, i.e., the phase difference detected by the phase comparator 51. The output signal of the all-pass filter can be demodulated by the AM demodulator 56 to obtain the phase-shifted reference potential signal.

[0048] <Fifth embodiment> According to the first and second embodiments, it is possible to measure biosignals with the same accuracy as conventional biosignal measurement systems using multiple electrode devices without physical wiring. Meanwhile, the reference potential output changes in a stepwise manner depending on the sampling rate of the device, so the reference potential remains constant until the next sampled value is transmitted, and the reference potential signal changes in a stepwise manner. However, because the true reference potential is constantly changing, this difference is output as an error, and there is a problem that the suppression performance of the common-mode (in-phase) component is reduced.

[0049] To solve the above problem, in the fifth embodiment, a reference potential signal that changes stepwise is interpolated in a reference potential correction circuit provided in each electrode device (20, 30). Because the reference potential signal in the amplifier circuit (22, 32) contains a periodic noise component called 50 or 60 Hz hum, by estimating this periodic signal, it is possible to interpolate the reference potential signal that changes stepwise according to the sampling rate of the electrode device. The interpolation of the reference potential signal can be performed in either the electrode device (20, 30) or the biosignal generating device 40.

[0050] When implemented by the electrode device (20, 30), this is achieved by receiving a reference potential signal and then interpolating the reference potential until the next reception. On the other hand, when implemented by the biosignal generating device 40, the interpolated results in the biosignal generating device 40 can be transmitted to the electrode device (20, 30). This interpolation may be performed by identifying frequency information using a Fourier transform or a wavelet transform.

[0051] Furthermore, when performing the above-mentioned interpolation, the use of an auto-regressive (AR) model allows for the interpolation to be performed with a small amount of calculation, which has the advantage of being easily implemented in the electrode devices (20, 30). The AR model approximates a signal using multiple coefficients called AR coefficients. The number of these AR coefficients is a parameter that can be determined arbitrarily by the designer, but the amount of data is generally smaller than that used for estimation. Therefore, by configuring the biosignal generating device 40 to calculate the AR coefficients and send these values ​​to the electrode devices (20, 30), the amount of communication can be reduced, and the amount of calculation in the electrode devices (20, 30) can be reduced, which is expected to reduce the power consumption of the electrode devices (20, 30). [Industrial Applicability]

[0052] The present invention can be applied to bioelectrodes that are routinely used to acquire biosignals such as electrocardiogram signals, and biosignal measurement systems that use bioelectrodes. [Explanation of symbols]

[0053] 1...wearer, 2...clothing, 10...biological signal measurement system, 20, 30...electrode device, 21, 31...electrode, 22, 32...amplification circuit, 23, 33...quantization circuit, 24, 34...wireless transmitter, 25, 35...power supply, 26, 36 wireless receiver, 40...biological signal generating device, 41...wireless receiver, 42...arithmetic circuit, 43...memory.

Claims

1. a plurality of electrode devices each having electrodes for measuring biopotentials, an amplifier circuit for amplifying the measured biopotentials, a quantizer circuit for converting the amplified biopotentials into digital data to generate biopotential information, a wireless transmitter for transmitting the biopotential information, a wireless receiver for receiving reference potential information of the amplifier circuit, and a power source for supplying power to the amplifier circuit, the quantizer circuit, the wireless transmitter, and the wireless receiver; a biosignal generating device including a wireless receiver that receives the biopotential information transmitted from the wireless transmitter of the electrode device, an arithmetic circuit that generates a biosignal waveform and the reference potential information using the biopotential information of at least two of the plurality of electrode devices, and a wireless transmitter that transmits the generated reference potential information to the electrode device; Equipped with The amplifier circuit of the electrode device amplifies the biopotential using the reference potential information received from the biosignal generating device. Biosignal measurement system.

2. The electrode device is equipped with the biosignal generating apparatus, and the arithmetic circuit of the electrode device generates the biosignal waveform and the reference potential information using the biopotential information measured by the electrode device and the biopotential information measured by another electrode device.

2. The biological signal measurement system according to claim 1.

3. the electrode device includes a reference potential correction circuit that corrects a phase fluctuation of the reference potential information caused by a propagation delay between the electrode device and the biological signal generating device; The amplifier circuit amplifies the biopotential using the reference potential information corrected by the reference potential correction circuit.

3. The biological signal measurement system according to claim 1 or 2.

4. The reference potential correction circuit estimates a lag in the data of the reference potential information using a correlation value calculated using a plurality of pieces of data of the reference potential information, and corrects a phase fluctuation of the reference potential information based on the estimated lag.

4. The biological signal measurement system according to claim 3.

5. The reference potential correction circuit a phase comparator for comparing the phase of the biopotential signal with that of a reference potential signal obtained from the reference potential information; a low-pass filter for outputting a DC component of the output of the phase comparator; an oscillator for outputting a signal of a frequency corresponding to the output of the low-pass filter; a modulator for amplitude-modulating the reference potential information using the output of the oscillator; an all-pass filter for inputting the output signal of the modulator; and a demodulator for demodulating the output signal of the all-pass filter; The output signal of the demodulator is output as the corrected reference potential.

4. The biological signal measurement system according to claim 3.

6. the electrode device includes a reference potential correction circuit that interpolates the reference potential that changes stepwise in accordance with a sampling rate of the electrode device by estimating a periodic signal included in the reference potential signal in the amplifier circuit; The amplifier circuit amplifies the biopotential using the reference potential interpolated in the reference potential correction circuit.

3. The biological signal measurement system according to claim 1 or 2.

7. The reference potential correction circuit uses an AR model to interpolate the reference potential.

7. The biological signal measuring system according to claim 6.

8. The reference potential correction circuit interpolates the reference potential information that changes stepwise using the AR coefficient calculated by the biological signal generating device.

8. The biological signal measuring system according to claim 7.

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