Tissue Care Devices

Abstract

We provide a new tissue care device that uses technology to spontaneously generate ion flow through enzyme reactions. [Solution] The biological tissue care device disclosed herein comprises a base portion that is placed at a predetermined position near biological tissue having a mucosa, and a device portion that is placed at a specific location on the base portion, and the device portion includes an ion flow generator that uses technology to spontaneously generate ion flow through an enzymatic reaction.

Description

[Technical Field]

[0001] The present disclosure relates to tissue care devices for use in the care, treatment, or prophylaxis of various mucosal tissues, such as those in the oral cavity, skin, eyes, nasal passages, ears, gastrointestinal tract, and urinary system. [Background technology]

[0002] In recent years, in the fields of beauty and medicine, devices known as biobatteries that are attached to the skin to pass electricity have become known. For example, Patent Document 1 discloses a patch for attachment to biological tissue that spontaneously generates an electric current through an enzymatic reaction when attached to the skin. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2014-207987 Summary of the Invention [Problem to be solved by the invention]

[0004] Until now, so-called biobattery technology has focused on devices that supply electricity to other devices used in living tissue. However, by focusing on the fact that not only does the enzyme reaction spontaneously generate an electric current but also creates a flow of ions (ion current), other applications are expected.

[0005] Therefore, the present disclosure has been made in consideration of the above problems, and its purpose is to provide a new biological tissue care device that uses technology to spontaneously generate ion flow through an enzyme reaction. [Means for solving the problem]

[0006] According to the present disclosure, a biological tissue care device is provided, comprising a base portion placed at a predetermined position near biological tissue having a mucous membrane, and a device portion placed at a specific location on the base portion, wherein the device portion includes an ion flow generator that uses technology to spontaneously generate ion flow through an enzymatic reaction, and the ion flow can provide therapeutic effects, preventive effects, or physiological activity promoting effects to the biological tissue. [Effects of the Invention]

[0007] According to the present disclosure, a new biological tissue care device can be provided that uses technology to spontaneously generate ion flow through an enzyme reaction. [Brief explanation of the drawings]

[0008] [Figure 1] 1 illustrates a tissue care device according to an embodiment of the present disclosure. [Figure 2] FIG. 2 is a cross-sectional view of FIG. 1 taken along line AA. [Figure 3] FIG. 2 is a plan view of a device portion of the embodiment. [Figure 4] FIG. 4 is a view showing a cross section BB in FIG. [Figure 5] FIG. 10 is a diagram showing a modified example of the device unit of the present embodiment. [Figure 6] FIG. 10 is a diagram showing a modified example of the device unit of the present embodiment. [Figure 7] FIG. 10 is a diagram showing a modified example of the device unit of the present embodiment. [Figure 8] FIG. 10 is a diagram showing a modified example of the device unit of the present embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0009] In the present disclosure, the term "biological tissue" refers to all tissues constituting a living organism, and is not particularly limited. For example, it includes not only externally accessible tissues such as skin, mucous membranes (oral mucosa, nasal mucosa, gastrointestinal mucosa, urogenital mucosa (including vaginal mucosa), ocular mucosa, etc.), teeth, gums, tongue, lips, cheeks, eye surface, eardrum, and ear canal, but also internal tissues accessible via endoscope, catheter, etc. (gastrointestinal mucosa, bronchial mucosa, blood vessel inner wall, etc.). It also includes not only healthy tissues but also tissues with inflammation, wounds, lesions, etc.

[0010] In this disclosure, the term "biological tissue care device" refers to a device used to provide at least one effect to biological tissue, such as treatment, prevention, protection, stimulation, activation, regeneration promotion, relaxation, conditioning, or cleansing. Here, "care" includes not only medical treatment but also non-medical uses such as cosmetic purposes, health maintenance, and quality of life improvement. Furthermore, the term "device" broadly includes instruments, machines, equipment, etc. that temporarily or continuously come into contact with biological tissue or that are located in the vicinity of biological tissue and exert an effect thereon.

[0011] In this disclosure, "spontaneously" means that ion flow is generated by a chemical reaction that occurs naturally in the installation environment without requiring an external power supply. In other words, it refers to a state in which electrons are transferred through a biochemical reaction, such as a reaction between an enzyme and a substrate, or a chemical reaction, without relying on power supplied from a battery or external power source, and thus an ion flow is generated. However, an auxiliary electrical or mechanical control mechanism may be added to control the initiation of the reaction. Furthermore, a sensor or the like may be provided to monitor the current value.

[0012] In this disclosure, "ion flow" (ionic current) refers to an electric current generated by the movement of ionic species (e.g., H+, Na+, K+, Cl-, etc.) along an electrochemical gradient in a solution or a wet environment. The ion flow in this disclosure occurs in conjunction with the movement of electrons resulting from enzyme reactions and the like, and by flowing on the surface or inside of biological tissues, it brings about various physiological effects on biological tissues. The strength, direction, distribution, duration, etc. of the ion flow can be adjusted by the electrode arrangement, the type and amount of enzyme, the concentration of the substrate, etc.

[0013] In this disclosure, "mucous membrane" refers to the moist tissue that covers the lumens and cavities in the body, and is composed of epithelial tissue and the lamina propria that supports it. Mucous membranes are generally moistened by bodily fluids and secretions, and function as a barrier against external stimuli and the invasion of pathogens. In this disclosure, mucous membranes include oral mucosa, nasal mucosa, ocular mucosa, gastrointestinal mucosa, respiratory mucosa, urogenital mucosa, and the like. In addition, in this disclosure, tissues such as skin that maintain a moist state similar to mucous membranes or can be made moist are also considered to be included in "biological tissues having mucous membranes."

[0014] Preferred embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings. In this specification and drawings, components having substantially the same functional configurations are designated by the same reference numerals, and redundant description will be omitted.

[0015] The biological tissue care device shown in Fig. 1 is a mouthpiece-type oral care device 1 that is placed in the oral cavity. Fig. 2 shows a cross section taken along line AA in Fig. 1. The user's teeth T and gums G are shown by imaginary lines.

[0016] The oral care device 1 includes a mouthpiece-shaped base portion 10 and a device portion 20 that is placed at a specific location on the base portion 10 .

[0017] The base 10 covers a part or the whole of the maxillary dentition, a part or the whole of the mandibular dentition, or a part or the whole of both the maxillary dentition and the mandibular dentition. "A part of the dentition" includes, for example, cases where only the front teeth or only the molars of the dentition are covered, or cases where part of the dentition has been removed or has an opening (through-hole), etc.

[0018] The device unit 20 is preferably configured to be detachable (removable) from the base unit 10 by the user. In this case, the base unit 10 can be used repeatedly by replacing only the device unit 20. Note that if the device unit 20 is integrally formed or fixed (adhered) to the base unit 10 in an inseparable manner, concerns about detachment during use can be eliminated. In this case, the base unit 10 and device unit 20 are replaced as a set.

[0019] The base unit 10 preferably has a recess (concave) 11 for attaching the device unit 20. The recess 11 preferably has substantially the same shape as the device unit 20, but is not particularly limited as long as the device unit 20 can be attached thereto. The presence of the recess 11 clarifies the position where the device unit 20 is attached. Furthermore, since the device unit 20 is less likely to protrude from the surface of the base unit 10, discomfort felt by the user when wearing the oral care device 1 can be reduced. A commercially available, general-purpose mouthpiece may be used as the base unit 10, to which the device unit 20 is attached, or a mouthpiece molded for each user may be used. When the base unit 10 has a recess 11, multiple recesses 11 may be provided on the base unit 10, allowing the device unit 20 to be attached at the required position depending on the application. In this case, the device unit 20 may be attached to all or only some of the recesses. Removable covers may be provided for recesses not to which the device unit 20 is attached to prevent unevenness on the base unit 10. In this case, discomfort during use due to unevenness can be suppressed. The device section 20 may be attached to the base section 10 by adhesion using a tape-like or gel-like adhesive, or by fitting or inserting the two sections into each other with a shape that fits together.

[0020] In the example of FIG. 1 , only a single device unit 20 is attached to the base unit 10, but multiple device units 20 may be arranged on the base unit 10. In this case, the range of effects obtained by the device unit 20 can be expanded. For example, if multiple device units 20 are arranged at equal intervals (or consecutively without any intervals) across the entire dentition, the effects of the device units 20 can be obtained across the entire dentition. The effects of the device units 20 will be described later. When multiple device units 20 are arranged, they may be independent of each other, or they may be connected in series or in parallel by connecting the anode (cathode) 21 a and the cathode (anode) 21 b of two adjacent device units 20 with a conductive part (for example, a wire similar to the conductive part 22).

[0021] In the example of FIG. 1 , the device unit 20 is configured to be located on the outer surface side of the user's front teeth. However, the device unit 20 may be configured to be installed at any position on the base unit 10. For example, when the user wears the oral care device 1, the device unit 20 may be located in a position corresponding to only the front teeth, only the molars, or both in the width direction of the dentition. In addition, the device unit 20 may be located in a position that contacts (or faces) the teeth, gums, or both in the height direction. Furthermore, the device unit 20 may be located in a position that contacts (or faces) any of the outer surface (lip side, cheek side), inner surface (palatal side, tongue side), or occlusal surface of the teeth. For example, the device unit 20 may be provided in a position that contacts both the outer surface and the inner surface of the teeth. Furthermore, the device unit 20 may be located so as to face the user's lips, cheek, or tongue. In other words, the device unit 20 may be located on either the inner surface side or the outer surface side of the base unit 10.

[0022] <Device section> An example of the device section 20 will be specifically described below.

[0023] Fig. 3 is a plan view of the device section 20 of this example, and Fig. 4 shows a cross section taken along line BB in Fig. 3. The device section 20 can be, for example, a flexible sheet-like or patch-like ion flow generator made only of organic materials.

[0024] The device section 20 includes two electrodes 21, each consisting of an anode (cathode) 21a and a cathode (anode) 21b, and a conductive section 22 for electrically connecting the two electrodes 21 (21a, 21b). The two electrodes 21 are spaced apart in the longitudinal direction of the device 20, and the conductive section 22 is provided between them. The electrode 21 may have any shape, for example, a rectangular sheet shape in a plan view. The electrode 21 is preferably made of an elastically deformable organic material, such as a carbon fiber cloth. The conductive section 22 may be made of any conductive material, but is preferably made of an elastically deformable organic material, such as a linear member made of a carbon material. The magnitude of the ion flow can be controlled by the resistance value of the conductive section 22.

[0025] The anode 21a carries a catalyst 23a for the reduction reaction, and the cathode 21b carries an enzyme serving as a catalyst 23b for the oxidation reaction. The catalysts 23a and 23b are preferably applied to each electrode 21. A membrane 24 that allows oxygen to pass through is preferably provided on the upper side of the anode 21a. As shown in FIGS. 1 and 2, the base 10 preferably has an air intake 12 connected to the electrode 21a via the membrane 24, which prevents a decrease in effectiveness. The air intake 12 is preferably open at a position exposed to the outside. For example, in the case of a mouthpiece-type device, the air intake 12 is preferably open on the palate side, tongue side, occlusal surface side, or the like so as to be less likely to be blocked by biological tissue such as the inside of the cheek. The membrane 24 may not be provided on the upper side of the anode 21a, or may be provided on the upper side of the cathode 21b.

[0026] The device unit 20 in FIG. 4 includes ion-conductive layers 25 located below the two electrodes 21 (on the biological tissue side during use). The ion-conductive layers 25 may have any shape, but preferably have a shape corresponding to each electrode 21, such as a rectangular sheet in plan view. The ion-conductive layers 25 have ion conductivity. The ion-conductive layers 25 may be water-retaining bodies, preferably, but not limited to, sponges impregnated with physiological saline or the like. The ion-conductive layers 25 can prevent the enzymes 23a and 23b from leaking out. The device unit 20 includes a frame 26 for holding (supporting) the electrodes 21, the conductive portions 22, the ion-conductive layers 25, etc. in appropriate positions. The frame 26 is an insulator. The frame 26 is preferably made of an elastic material such as silicone rubber. The frame 26 is, for example, a thin sheet (or patch) rectangular in plan view, and is provided with recesses (including through-holes) for arranging the electrodes 21, the conductive portions 22, the ion-conductive layers 25, etc.

[0027] The device section 20 is preferably in the form of a thin sheet (or patch) as a whole. The thickness T of the device section 20 is preferably, for example, 0.5 mm or more and 3 mm or less, and more preferably 1.5 mm or more and 2.5 mm or less. By having the thickness T within the above range, both convenience and ease of manufacture can be achieved. That is, if the thickness T is too large, convenience may decrease, and if the thickness T is too small, manufacturability may decrease.

[0028] The device section 20 is preferably flexible and elastically deformable as a whole, which makes it easier to fit the shape of the base section 10 and also the shapes of the user's dentition, gums, etc.

[0029] The device unit 20 is stored in a dry state before use. When the device unit 20 is used, liquid (moisture) is applied by submerging or pouring water on it, causing the ion conductive layer 25 to absorb the water and dissolve reactive molecules and electrolytes at the anode, resulting in a catalytic reaction at the electrode 21, enabling the device unit 20 to generate an ion flow. Even when used in a dry state, bodily fluids such as saliva can similarly enable the device unit 20 to generate an ion flow. Arrow C in FIG. 4 indicates the flow (ion flow) of positive ions (e.g., H+, Na+, etc.). The ion flow C flows outside the device 20 (e.g., on the surface of biological tissue, etc.).

[0030] When a user attaches the oral care device 1 to the oral cavity in the same manner as a normal mouthpiece, the device portion 20 generates an ion flow C, which flows over the surfaces of the gums, teeth, and other oral tissues. As a result, it is possible to obtain effects such as massaging the gums, promoting blood circulation, stimulating the salivary glands, suppressing electrostatic adhesion of plaque, and promoting orthodontic treatment using the mouthpiece.

[0031] The mechanism of action of the effect of the ion flow C on biological tissue will be explained in detail. For example, when the ion flow C flows through biological tissue (e.g., gums), it changes the cell membrane potential of the biological tissue. This induces biochemical changes such as an increase in calcium ion concentration within the cells, promoting cell activation. In addition, the massage effect caused by the electroosmotic flow generated in the biological tissue promotes blood circulation.

[0032] Ion flow C promotes an increase in local blood flow. This is thought to be due to the fact that ion flow C induces the production of physiologically active substances such as nitric oxide (NO), which is involved in vasodilation, and affects the balance between contraction and relaxation of smooth muscle cells. Increased blood flow promotes the supply of oxygen and nutrients, increases the metabolic activity of tissues, and also promotes the removal of waste products.

[0033] In addition, the electrochemical action of ion flow C inhibits the membrane function and metabolism of microorganisms such as bacteria. In particular, it can suppress the growth of bacteria involved in plaque formation. This is thought to be because ion flow C acts on the bacterial cell membrane, changing the membrane potential and inhibiting the metabolic activity of the bacteria. It also has the effect of preventing electrostatic adhesion of bacteria and the formation of biofilms.

[0034] Furthermore, the ion flow C affects the electrical repulsion and attraction of surrounding charged particles (such as plaque constituents). In particular, since plaque is usually negatively charged particles, when a flow of positive ions of the ion flow C is formed, an electrostatic interaction occurs between the particles and the plaque constituents. This interaction inhibits the adhesion of plaque to the tooth surface and promotes the detachment of plaque that has already adhered.

[0035] Furthermore, ion flow C has the effect of promoting the activity of secretory glands such as the salivary glands. In particular, when ion flow C flows around salivary glands such as the submandibular gland, sublingual gland, and parotid gland, it stimulates the glandular cells and promotes saliva secretion. Saliva has antibacterial, buffering, and cleansing properties, which contribute to improving the self-cleaning function of the oral cavity.

[0036] Furthermore, ion current C also acts on nerve tissue, and weak currents below a certain threshold may produce an analgesic effect by gently stimulating sensory nerves. This may be particularly effective against chronic pain associated with gingivitis and periodontitis, as well as pain associated with orthodontic treatment.

[0037] Furthermore, ion flow C has the effect of promoting the effects of orthodontic treatment involving tooth movement. By improving blood flow and metabolic activity in periodontal tissues, ion flow C maintains the health of periodontal tissues and promotes tissue turnover during orthodontic treatment. Ion flow C may also promote the remodeling process of periodontal ligament fibers. Tooth movement during orthodontic treatment involves repeated degradation and remodeling of periodontal ligament fibers, and ion flow C is thought to make this process more efficient by regulating collagen synthesis and orientation. Furthermore, ion flow C may regulate the activity of osteoclasts (involved in bone resorption) and osteoblasts (involved in bone formation), accelerating the bone remodeling process.

[0038] These mechanisms of action not only work independently, but can also interact with each other to produce synergistic effects. Furthermore, by adjusting parameters such as the intensity, pattern (continuous or intermittent), and duration of the ion flow C, it is possible to prioritize a specific mechanism of action. For example, a low-intensity continuous ion flow C can promote cell activation, while a higher-intensity intermittent ion flow C can promote saliva secretion and enhance bactericidal effects.

[0039] These mechanisms of action work not only in the oral cavity, but also in other mucosal tissues, skin, etc. For example, when applied to the skin, it is expected to have effects such as activating skin metabolism by promoting blood circulation and promoting wound healing. When applied to the ocular mucosa, it is expected to have effects such as promoting tear secretion and activating corneal epithelial cells. When applied to the nasal mucosa, it is expected to have effects such as optimizing mucus secretion and protecting the mucosal epithelium. When applied to the urogenital mucosa, it is expected to have effects such as improving the chances of pregnancy (infertility treatment), improving menstrual pain (so-called "femcare"), and preventing sexually transmitted diseases. In this way, effects on various physiological and pathological conditions can be obtained depending on the type of biological tissue.

[0040] It is preferable that the device part 20 is positioned so as to straddle the teeth and gums when the user wears the oral care device 1, in which case it is possible to achieve both the effect of suppressing plaque adhesion to the teeth and the effect of massaging the gums.

[0041] When the user wears the oral care device 1, the device portion 20 is preferably positioned so as to cover the entire area from one molar to the other, in which case a flow can be created across the entire dental arch.

[0042] Fig. 5 shows a modified device section 120. The device section 120 of Fig. 5 includes microneedles 27 in addition to the configuration of Fig. 4. The device section 120 includes a plurality of microneedles 27 and a needle fixing section 28 for fixing the microneedles 27 to the frame 26. The needle fixing section 28 is made of, for example, silicone rubber. Holes are formed in the needle fixing section 28 for fixing and holding the microneedles.

[0043] The microneedles 27 (e.g., porous microneedles) are ion conductors and can be made of sponge, hydrogel, xerogel, resin, or the like. A microneedle array may be formed by fitting a plurality of microneedles 27 into a needle fixing portion 28 to form an integrated unit. The microneedles 27 are disposed below the ion conductive layer 25 (the biological tissue side), preferably so that the bases of the microneedles 27 are in contact with the ion conductive layer 25. The tips of the microneedles 27 are, for example, conical, allowing the tips to penetrate the surface of biological tissue and be inserted into the interior. The microneedles 27 preferably have a void therein that serves as a flow path for liquid, gas, or the like, and the base and tip sides are preferably connected by this flow path. The microneedles 27 may be formed of any material, but are preferably formed of an organic substance, such as a hydrogel or a porous body.

[0044] When the device section 120 of Fig. 5 is used, the microneedles 27 penetrate the surface of the biological tissue and enter the interior, allowing the ion flow C to flow inside the biological tissue (e.g., gums, etc.). In addition, by adjusting the arrangement of the microneedles 27, it is possible to control the position (path) through which the ion flow C flows. When the surface resistance of the biological tissue is high and the internal resistance is low, the ion flow C can be efficiently flowed inside, thereby enhancing the effectiveness of the biological tissue care device.

[0045] FIG. 6 shows a modified device section 220. In addition to the configuration of FIG. 4, the device section 220 of FIG. 6 includes a tank section 29 having an internal space. The tank section 29 can store gel or liquid water, and preferably has an air intake opening 29a formed on its side. The opening 29a is not a required component, and the tank section 29 may be configured to shrink as the contents decrease. The tank section 29 also has a water supply hole 29b that can supply water from the tank to the conductive layers (25a, 25b). The ion conductive layer 25a located below the cathode 21a is fixed in a positively charged state and is formed, for example, by impregnating a sponge with a positively charged gel. The ion conductive layer 25b located below the anode 21b is fixed in a negatively charged state and is formed, for example, by impregnating a sponge with a negatively charged gel.

[0046] When the device unit 220 in FIG. 6 is in use, the liquid contained in each ion conductive layer 25a, 25b is delivered to the biological tissue as an electroosmotic flow accompanied by the flow of ion flow C, as described above (see thick arrow S). That is, the ion flow C is positive ions, and the water in the positive ion conductive layer 25a flows in the opposite direction to the ion flow C, while the water in the negative ion conductive layer 25b flows in the same direction as the ion flow C. Furthermore, when the liquid contained in the ion conductive layers 25a, 25b is delivered to the biological tissue, the water in the tank unit 29 automatically moves to the ion conductive layers 25a, 25b. Therefore, the ion conductive layers 25a, 25b are replenished with water equivalent to the amount of water in the tank unit 29, allowing the device to continue to exert its effects. If a gel is placed in the tank unit 29, the gel is used to retain the liquid.

[0047] The device unit 220 shown in FIG. 6 allows the liquid in the conductive layers (25a, 25b) and the tank unit 29 to be applied to biological tissue. As a result, for example, by supplying water to the dentition, the effect of the ion flow C can be enhanced, the duration of the effect can be extended, and the effect can be improved. Furthermore, various problems caused by a lack of saliva in the oral cavity (such as tooth decay, periodontal disease, bad breath, stomatitis, and changes in taste) can be alleviated. Furthermore, by applying a drug or the like to at least one of the conductive layers (25a, 25b) and the tank unit 29, the drug can be administered to a desired location in the oral cavity (the location of the device 20). The liquids in the conductive layers (25a, 25b) and the tank unit 29 may be the same or different. Examples of the drug include an analgesic, a periodontal remedy, a whitening agent, a purifying agent (bactericide), and a pH buffer. It is preferable that the device unit 220 be positioned at an appropriate location to administer the drug depending on the type of drug. For example, when a whitening agent is used as the drug, it is desirable that the device portion 220 be disposed so as to come into contact with the outer surface of the tooth (including the position spanning the tooth and gums). In the case of a painkiller, a periodontal disease drug, or the like, it is desirable that the device portion 220 be disposed so as to come into contact with the gums. Therefore, for example, it is desirable that a recess for disposing the device portion 220 be provided at an appropriate position in the base portion.

[0048] FIG. 7 shows a device section 320 as a further modification. In addition to the configuration of FIG. 6, the device section 320 of FIG. 7 includes a plurality of microneedles 27 and a needle fixing section 28 similar to the device section 120 of FIG. 5. When the device section 320 is used, for example, the liquid in the conductive layers (25a, 25b) and the tank section 29 can be applied to the inside of biological tissue through the microneedles 28 with high precision. As a result, it is possible to effectively administer a drug or efficiently apply moisture to a desired location.

[0049] FIG. 8 shows a device section 420 as another modified example. In addition to the configuration of FIG. 6, the device section 420 of FIG. 8 has a space 30 formed below the conductive layers (25a, 25b) and the conductive section 22. The device section 420 is configured such that ion flow C flows through the space 30, but the ion flow C does not substantially flow (or does not flow easily) to the outside. In this case, the liquid contained in each ion conductive layer 25a, 25b can be delivered to the outside of the device section 420 without causing the ion flow C to flow outside the device section 420 (see arrow S). A film 31 (membrane) that forms the space 30 is provided on the underside of the device section 420. Although the film 31 has holes that allow liquid to pass through, when not in use, the liquid contained in the ion conductive layers 25a, 25b does not leak out, but is delivered from the device section 420 to the biological tissue by the delivery pressure (water pressure).

[0050] As described above, the biological tissue care device 1 of this embodiment includes a base section 10 that is placed at a predetermined position near biological tissue (G) having a mucosa, and a device section 20 that is placed at a specific location on the base section 10. The device section 20 includes an ion flow generator that uses technology to spontaneously generate ion flow through an enzyme reaction. With this configuration, the moisture in the mucosa facilitates the flow of ions, allowing the ions to flow effectively near the mucosa, thereby achieving effects such as massaging biological tissue and promoting blood circulation.

[0051] In this embodiment, the ion flow generating device preferably includes a plurality of electrodes including an electrode carrying an enzyme that catalyzes an oxidation-reduction reaction, a conductive portion for electrically connecting the plurality of electrodes, and a conductive layer located closer to the biological tissue than the plurality of electrodes.

[0052] In this embodiment, the conductive layer may be a water absorbent that does not contain substantially water when not in use. In this case, the generation of ion flow can be initiated by supplying water to the water supply body immediately before or during use.

[0053] In this embodiment, the base portion may be formed with an intake hole for supplying oxygen to the device portion 20. By doing so, oxygen can be continuously supplied to the electrodes, thereby preventing a decrease in the effectiveness of the device portion 20.

[0054] In this embodiment, the device portion may include a microneedle connected to the conductive layer, which allows for efficient ion flow and drug administration inside the biological tissue.

[0055] In this embodiment, the device section may include a tank section for supplying a predetermined liquid to the conductive layer. By storing a desired liquid (including gel) in the tank section, any liquid can be applied to biological tissue.

[0056] In this embodiment, the device unit may be configured to be detachable from the base unit, which allows, for example, the base unit to be attached once and then detached to adjust its position, or the base unit to be used repeatedly while only the device unit is replaced with a new one.

[0057] In this embodiment, the base portion may have a recess formed therein for attaching the device portion. This clarifies the position where the device portion is attached to the base portion. Furthermore, since the device portion is less likely to protrude from the surface of the base portion, the discomfort felt by the user when wearing the oral care device 1 can be reduced.

[0058] In this embodiment, the base portion may be configured to have a plurality of recesses formed therein, allowing the user to select any recess to attach the device portion 20. This allows the effect of the device portion 20 to be imparted to a desired position.

[0059] In this embodiment, the base portion may be arranged inside the oral cavity. The base portion is not limited to the mouthpiece type, and may be arranged under the tongue, on the roof of the mouth, or the like.

[0060] In this embodiment, the device unit may include a plurality of ion flow generators arranged along the tooth row. This allows the effect of the device unit 20 to be applied to a wide range of the tooth row. The plurality of ON current generators may be connected in series along the tooth row.

[0061] In this embodiment, the device unit may have a space for allowing ions to flow, located closer to the biological tissue than the conductive layers. In this case, the ions flow through the space, and the liquid contained in each conductive layer can be delivered to the outside of the device unit (biological tissue) without causing the ions to flow outside the device unit.

[0062] Examples of materials for the electrode 21 and the conductive portion 22 include carbon materials such as carbon nanotubes, Ketjen Black (registered trademark), Glassy Carbon (registered trademark), graphene, fullerene, carbon fiber, carbon fabric, and carbon aerogel; conductive polymers such as polyaniline, polyacetylene, polypyrrole, poly(p-phenylene vinylene), polythiophene, and poly(p-phenylene sulfide); semiconductors such as silicone, germanium, indium tin oxide (ITO), titanium oxide, copper oxide, and silver oxide; and metals such as gold, platinum, titanium, aluminum, tungsten, copper, iron, and palladium. Carbon materials such as carbon fabric and carbon nanotubes are particularly preferred from the standpoints of flexibility and electrochemical stability. In particular, when immobilizing an enzyme on an electrode at a high density, carbon fabric modified with carbon nanotubes is preferred.

[0063] The cathode 21a is supported with a catalyst that catalyzes the reduction reaction. Examples of such catalysts include enzymes such as bilirubin oxidase (BOD), laccase, and Cu efflux oxidase (Cueo); and transition metal complexes such as iron(II) phthalocyanine.

[0064] The anode 21b supports a catalyst that catalyzes an oxidation reaction. Examples of such catalysts include oxidoreductases such as glucose oxidase, glucose dehydrogenase (GDH), fructose dehydrogenase (D-fructose dehydrogenase (FDH), alcohol oxidase, alcohol dehydrogenase, lactate oxidase, and lactate dehydrogenase.

[0065] The ion conductive layer 25 is composed of a water absorbent and is disposed in contact with each electrode 21. The ion conductive layer 25 has a structure in which dried fuel or electrolyte is contained within a sponge. The water absorbent in contact with the anode 21b contains a fuel, such as an organic substance, that undergoes an oxidation reaction at the anode. Examples of fuel include glucose, fructose, ascorbic acid (vitamin C), alcohol, and lactic acid. Examples of sponge materials include synthetic resins such as polyurethane and polyvinyl alcohol; natural polymers such as cellulose; and their derivatives. The sponge contains fine open cells. Therefore, by absorbing an electrolyte solution consisting of an aqueous electrolyte solution into the sponge and then drying it, the solute electrolyte within the sponge becomes dry. At least a portion of the electrolyte may be exposed in a solid state on the inner wall surfaces of the cells without being incorporated into the sponge material. In addition to the electrolyte, the sponge may contain fuel for a biobattery, a drug that can act on a living body, other additives, etc.

[0066] The microneedles can be made of sponge, hydrogel, xerogel, resin, metal, or the like.

[0067] Although the preferred embodiments of the present disclosure have been described in detail above with reference to the accompanying drawings, the technical scope of the present disclosure is not limited to such examples. It is clear that a person skilled in the art of the present disclosure can conceive of various modified or altered examples within the scope of the technical idea described in the claims, and it is understood that these also naturally fall within the technical scope of the present disclosure.

[0068] For example, in the above embodiment, the base unit 10 is a mouthpiece type, but is not limited to this, and the base unit 10 can have any shape depending on the application and environment. For example, when placed under the tongue, the base unit 10 may have a shape corresponding to the shape inside the mandible (inside the lower dentition), and when placed in the nasal cavity, the base unit 10 may be ring-shaped, cylindrical, or the like, corresponding to the shape of the inner surface of the nasal cavity. Furthermore, when placed in the eye, the base unit 10 may be contact lens-shaped, and when placed in the rectum or vagina, the base unit 10 may be ring-shaped, cylindrical, or the like, corresponding to the shape of the inner surface of the rectum or vagina.

[0069] Furthermore, the effects described herein are merely descriptive or exemplary and are not limiting. In other words, the technology according to the present disclosure may achieve other effects that will be apparent to those skilled in the art from the description of this specification, in addition to or in place of the above-described effects.

[0070] The following configurations also fall within the technical scope of the present disclosure. (Item 1) a base portion to be placed at a predetermined position near biological tissue having a mucosa; a device portion disposed at a specific location on the base portion, The device portion is a biological tissue care device including an ion flow generator that uses a technology for spontaneously generating ion flow through an enzyme reaction. (Item 2) The biological tissue care device described in item 1, wherein the ion flow generating device includes a plurality of electrodes including an electrode carrying an enzyme that catalyzes an oxidation-reduction reaction, a conductive portion for electrically connecting the plurality of electrodes, and a conductive layer located closer to the biological tissue than the plurality of electrodes. (Item 3) 3. The biological tissue care device according to item 2, wherein the conductive layer is a water-absorbent body that does not substantially contain water when not in use. (Item 4) Item 1. The biological tissue care device according to item 1, wherein the base portion has an intake hole formed therein for supplying oxygen to the device portion. (Item 5) 3. The biological tissue care device of claim 2, wherein the device portion includes microneedles connected to the conductive layer. (Item 6) 3. The biological tissue care device according to item 2, wherein the device portion includes a tank portion for supplying a predetermined liquid to the conductive layer. (Item 7) Item 2. The biological tissue care device according to item 1, wherein the device portion is configured to be detachable from the base portion. (Item 8) 8. The biological tissue care device according to item 7, wherein the base portion has a recess formed therein for attaching the device portion. (Item 9) Item 9. The biological tissue care device according to item 8, wherein a plurality of recesses are formed in the base portion, and the user is configured to be able to select any of the recesses and attach the device portion. (Item 10) Item 10. The tissue care device of item 1, wherein the base portion is placed in the oral cavity. (Item 11) Item 11. The biological tissue care device of item 10, wherein the base portion is a mouthpiece type. (Item 12) Item 12. The biological tissue care device according to item 11, wherein the device portion includes a plurality of the ion flow generators arranged along the tooth row. (Item 13) Item 13. The tissue care device of item 12, wherein the plurality of ion flow generators are connected in series along the tooth row. (Item 14) 7. The biological tissue care device according to item 6, wherein the device portion is located closer to the biological tissue than the conductive layer and has a space for allowing ions to flow. [Explanation of symbols]

[0071] 1. Biotissue care devices 10 Base 20 Device Section 21 electrodes 21a Anode (cathode) 21b Cathode (anode) 22 Conductive part 23a, 23b enzymes 25 Conductive layer

Claims

1. a base portion to be placed at a predetermined position near biological tissue having a mucosa; a device portion disposed at a specific location on the base portion, the device section includes an ion flow generator that uses a technology for spontaneously generating an ion flow through an enzyme reaction; the device section is configured to be detachable from the base section, A biological tissue care device in which a plurality of recesses are formed in the base portion, and the device portion is configured so that a user can select any of the recesses to attach the device portion.

2. The biological tissue care device of claim 1, wherein the ion flow generating device includes a plurality of electrodes including an electrode carrying an enzyme that catalyzes an oxidation-reduction reaction, a conductive portion for electrically connecting the plurality of electrodes, and an ion conductive layer located closer to the biological tissue than the plurality of electrodes.

3. The tissue care device according to claim 2 , wherein the ion-conductive layer is a water-absorbent body that does not contain substantially water when not in use.

4. The tissue care device according to claim 1 , wherein the base portion has an intake hole formed therein for supplying oxygen to the device portion.

5. The tissue care device of claim 2 , wherein the device portion includes microneedles connected to the ion-conducting layer.

6. The biological tissue care device according to claim 2 , wherein the device portion includes a tank portion for supplying a predetermined liquid to the ion conductive layer.

7. A biological tissue care device as described in claim 1, wherein a used device portion can be removed from the base portion and a new device portion can be attached to the recess.

8. A biological tissue care device as described in Claim 6, wherein the tank portion is adjacent to the ion conductive layer, and fluid in the tank portion is supplied to the ion conductive layer through a water supply hole that connects the tank portion and the ion conductive layer.

9. A biological tissue care device as described in Claim 8, wherein the tank portion includes two tank portions each adjacent to a pair of ion conductive layers corresponding to the two electrodes, respectively.

10. The tissue care device of claim 1 , wherein the base portion is positioned within the oral cavity.

11. The tissue care device of claim 10 , wherein the base portion is a mouthpiece.

12. The biological tissue care device of claim 11 , wherein the device portion includes a plurality of the ion flow generators arranged along a row of teeth.

13. The tissue care device of claim 12 , wherein the plurality of ion flow generators are connected in series along the row of teeth.

14. The biological tissue care device according to claim 6 , wherein the device portion has a space for allowing ions to flow, the space being located closer to the biological tissue than the ion conductive layer.

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