Fluid Delivery Device

Abstract

To provide a fluid delivery device that can be easily reused. [Solution] The present disclosure relates to a fluid delivery device that delivers fluid by contacting a microneedle with biological tissue, comprising a base portion having an electrode portion connected to a power supply means, and a cap portion that is arranged to cover the electrode portion and is detachable from the base portion, the cap portion incorporating a fluid holding portion that supplies fluid to the microneedle, and is arranged so that the fluid holding portion comes into contact with the electrode portion when the cap portion is attached to the base portion.

Description

[Technical Field]

[0001] FIELD The present disclosure relates to fluid delivery devices. [Background technology]

[0002] Iontophoresis is a conventional drug administration method that promotes drug penetration by passing a small electric current through the body. Iontophoresis can administer drugs directly into blood vessels or the affected area, which has the advantage of allowing drugs to be administered more efficiently and minimizing side effects compared to conventional oral administration.

[0003] The present inventors have developed a porous microneedle with a fixed negative charge by chemical modification to generate a large electroosmotic flow on the positive electrode side (see, for example, Patent Document 1). It has been reported that this microneedle can allow a drug to penetrate under the skin regardless of the charge of the drug, i.e., regardless of the direction of electrophoresis.

[0004] In response to this, the present inventors have developed an electroosmotic flow pump that uses a material with a fixed negative charge on the positive electrode side and a material with a fixed positive charge on the negative electrode side, which is capable of supplying drugs to the surface of the skin or tissue using electroosmotic flow from both the positive and negative electrode sides without interfering with drug penetration on the negative electrode side (see, for example, Patent Document 2). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Publication No. 2022-83780 [Patent Document 2] Japanese Patent Application Publication No. 2023-69170 Summary of the Invention [Problem to be solved by the invention]

[0006] The microneedles of Patent Document 1 allow drugs to penetrate beneath the skin regardless of the charge of the drug, i.e., regardless of the direction of electrophoresis. Furthermore, the electroosmotic pump described in Patent Document 2 can deliver drugs to the surface of the skin or tissue from both the positive and negative poles, thereby increasing the amount of drug administered. However, existing technologies leave room for improvement in terms of easily and repeatedly delivering drugs to biological tissues.

[0007] SUMMARY OF THE INVENTION The present disclosure has been made in view of the above problems, and has as its object to provide a fluid delivery device that can be easily used repeatedly. [Means for solving the problem]

[0008] According to the present disclosure, there is provided a fluid delivery device that delivers a fluid by bringing a microneedle into contact with biological tissue, comprising: a base portion having an electrode portion connected to a power supply means; a cap portion disposed to cover the electrode portion and detachable from the base portion, The cap portion has a built-in fluid holding portion for supplying a fluid to the microneedle, There is provided a fluid delivery device in which the fluid holding portion is arranged to contact the electrode portion when the cap portion is attached to the base portion. [Effects of the Invention]

[0009] The present disclosure provides a fluid delivery device that can be easily reused. [Brief explanation of the drawings]

[0010] [Figure 1] 1 is a cross-sectional view illustrating a configuration example of a fluid delivery device according to an embodiment of the present disclosure. [Figure 2] FIG. 2 is an enlarged partial view of the fluid delivery device of FIG. [Figure 3]2A-2C are cross-sectional views of different angles of the fluid delivery device of FIG. 1. [Figure 4] 2 is a perspective view of a cap portion of the fluid delivery device of FIG. 1. FIG. [Figure 5] FIG. 2 is a conceptual diagram for explaining the fluid delivery device according to the embodiment. [Figure 6] FIG. 2A is a perspective view showing an array of positive and negative microneedles of the fluid delivery device according to the embodiment, and FIG. 2B is an enlarged side view of one negative microneedle. [Figure 7] FIG. 10 is a conceptual diagram for explaining a modified example of the fluid delivery device of the present embodiment. [Figure 8] FIG. 8 is a cross-sectional view showing the fluid delivery device of FIG. 7 in use. DETAILED DESCRIPTION OF THE INVENTION

[0011] Preferred embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings. In this specification and drawings, components having substantially the same functional configurations are designated by the same reference numerals, and redundant description will be omitted.

[0012] The fluid delivery device 100 shown in FIG. 1 is a fluid delivery device that delivers a fluid by bringing microneedles 130 into contact with biological tissue (that is, injects a fluid into biological tissue).

[0013] The fluid delivery device 100 comprises a base portion 110 and a cap portion 120 .

[0014] As shown in FIG. 2, the base unit 110 has an electrode unit 111 connected to a power supply. The electrode unit 111 has, for example, a first electrode 111a and a second electrode 111b. Each electrode may be formed by a screw or other conductive material. In this example, the screw constituting the electrode is inserted from inside the base unit, and the tip of the screw (through the partition) protrudes toward the outside of the base unit (inside the cap unit 120). Either the first electrode 111a or the second electrode 111b may be positive and the other negative. The power supply is preferably, for example, a dry battery 113, but is not limited thereto and may be any power source such as an AC power source. FIG. 1 shows the base unit 110 with the battery cover removed so that the dry battery can be replaced, and FIG. 3 shows the base unit 110 with the battery cover 115 attached.

[0015] The cap portion 120 is disposed so as to cover the electrode portion 111, and is detachable from the base portion 110. Fig. 4 shows the cap portion 120 removed from the base portion 110. The cap portion 120 may be held, for example, by fitting a protrusion 123 provided on the inner surface into a recess in the base portion (so-called claw fitting), or the cap portion 120 may be held to the base portion 110 by other holding means such as press fitting, adhesive, or screws.

[0016] 2 and 4, the microneedles 130 are provided on the end surface of the cap portion 120, with their tips exposed to the outside. The tips of the microneedles 130 are inserted through the epidermis of biological tissue when the fluid delivery device 100 is in use. This allows fluid to be injected from the fluid holding portion 140 into the biological tissue via the microneedles 130.

[0017] The fluid holding unit 140 is built into the cap unit 120 and holds the fluid to be supplied to the microneedles 130. The fluid holding unit 140 is preferably a water-absorbent body capable of soaking in a liquid or gel-like medicinal solution, but may be made of any material capable of holding a fluid. The water-absorbent body may be, for example, a sponge, gel, cotton, or the like. Examples of sponge materials include synthetic resins such as polyurethane and polyvinyl alcohol; natural polymers such as cellulose, and derivatives thereof. The fluid holding unit 140 may be built into the cap unit 120 surrounded by a tubular member 141 (sponge holder). This makes it easier to stabilize the posture and shape of the fluid holding unit 140 within the cap unit 120. Furthermore, when replacing the fluid holding unit 140, the entire tubular member 141 can be removed from the cap unit 120, making the replacement process easier.

[0018] The fluid holding portion 140 is disposed so as to come into contact with the electrode portion 111 when the cap portion 120 is attached to the base portion 110. The fluid holding portion 140 is flexibly deformable upon contact with the electrode portion 111. The fluid holding portion 140 may be provided with a hole or a notch for inserting the electrode portion 111. The electrode portion 111 may have, for example, a first electrode 111a and a second electrode 111b, and the fluid holding portion 140 may have, for example, a first fluid holding portion 140a in contact with the first electrode 111a and a second fluid holding portion 140b in contact with the second electrode 111b.

[0019] The microneedle 130 may have a first microneedle 130a that delivers fluid from the first fluid holding portion 140a, and a second microneedle 130b that delivers fluid from the second fluid holding portion 140b.

[0020] An insulating wall 150 protruding from the cap portion may be provided between the first microneedle 130a and the second microneedle 130b. The tip of the insulating wall 150 may protrude further from the cap portion 120 than the microneedle 130. This can suppress conduction between the first microneedle 130a and the second microneedle 130b without going through (passing through) biological tissue, thereby enhancing the effect of passing ion current, medicinal solution, and the like through biological tissue.

[0021] The insulating wall 150 may be configured to elastically deform when pressed against the biological tissue when the microneedle 130 is brought into contact with the biological tissue. In other words, the material of the insulating wall 150 is preferably an elastic material such as silicone or rubber. This allows the microneedle 130 to be brought into contact with the biological tissue, allowing ionic current, medicinal solution, and the like to easily pass through the biological tissue, while maintaining the insulating effect of the insulating wall 150. The insulating wall 150 may be formed integrally with the cap portion 120. The material of the insulating wall 150 is preferably water-repellent. This makes it difficult for medicinal solution delivered from the microneedle 130 to overcome the insulating wall 150 and reach the microneedle 130 on the opposite side, thereby enhancing the insulating effect. The insulating wall 150 is preferably formed in a ring shape so as to surround each microneedle 130.

[0022] The first fluid holding portion 140a and the second fluid holding portion 140b may be arranged in a first storage space 121a and a second storage space 121b, respectively, formed in the cap portion 120 (see FIG. 4). The first storage space 121a and the second storage space 121b are recesses provided in the cap portion 120. The first storage space 121a and the second storage space 121b are separated by a wall 122 made of an insulating member. The first storage space 121a and the second storage space 121b are arranged such that, when the cap portion 120 is attached to the base portion 110 (attached state), the tip ends of the first electrode 111a and the second electrode 111b enter the first storage space 121a and the second storage space 121b, respectively. The first storage space 121a and the second storage space 121b each form a flow path that communicates from the base portion 110 side to the microneedle 130 side. One end of the first storage space 121a and the second storage space 121b opens to the base portion 10 side, and the other end opens to the microneedle 130 side. In other words, one end of the first storage space 121a and the second storage space 121b is covered by the wall of the base portion 10 (the wall surface from which the electrode portion 111 protrudes), and the other end is covered by the first microneedle 130a and the second microneedle 130b, respectively.

[0023] The base unit 110 may include a gripping portion that is held by the user during use. The gripping portion is preferably shaped so that the user can hold it with one hand. The gripping portion may be rod-shaped extending in the left-right direction in FIGS. 1 and 3, or may be ball-shaped like a sphere. More specifically, the gripping portion may be pen-shaped, held like a pen, ball-grip-shaped, or brush-grip-shaped like a comb. The base unit 110 may have a fastener such as a belt or band-shaped fastener for fastening to the head, neck, chest, abdomen, waist, buttocks, arms, wrists, legs, ankles, fingers, or toes.

[0024] The fluid holding unit 140 may be configured to be replaceable by removing the cap unit 120 from the base unit 110. In this case, when the medicinal solution in the fluid holding unit 140 runs out due to use, it can be replaced with a fluid holding unit 140 containing a new medicinal solution. Note that the used cap unit 120 may be removed from the base unit 110 and the entire cap unit 120 may be replaced with a new one, or only the fluid holding unit 140 (or the set of the fluid holding unit 140 and the tubular member 141) may be replaced, or new medicinal solution may be injected into the fluid holding unit 140 and allowed to soak in. In any case, even if the medicinal solution in the fluid holding unit 140 runs out, the fluid delivery device 100 can be repeatedly used by replacing some parts.

[0025] When using the fluid delivery device 100, the microneedles 130 are pressed against biological tissue such as the scalp or other skin. This allows the microneedles 130 to penetrate the epidermis of the biological tissue and deliver a medicinal solution or the like into the biological tissue. When pressed against the biological tissue, the fluid delivery device 100 is energized and delivers the medicinal solution or the like. The fluid delivery device 100 may be equipped with a notification means that utilizes the power. For example, the notification means may include a vibration device 160 that generates vibrations, a lighting unit that generates light, a speaker that generates sound, or the like, or a combination of these. When the microneedles 130 are pressed against the biological tissue and energized, power is supplied from a power source (battery 113) to the notification means. One or more of these notification means can easily notify the user that the medicinal solution or the like has been successfully injected. In this example, a vibration device 160 is provided, which generates vibrations for a short period of time (e.g., 0.5 seconds, 1 second, etc.) to indicate the start of energization, making it easier for the user to understand that energization has started. Note that the device may also vibrate after a predetermined time (e.g., 10 seconds, 30 seconds, 1 minute, 5 minutes, etc.) has elapsed since the start of energization to notify the user of the timing for termination, or may vibrate for a short period of time repeatedly each time a predetermined time has elapsed to notify the user of the passage of time. Such notification conditions, such as vibration, may be stored in a memory unit of a control device provided in the base unit 110 and controlled by a control processing unit.

[0026] As described above, the fluid delivery device 100 of this embodiment is a fluid delivery device that delivers fluid by bringing microneedles into contact with biological tissue, and includes a base having an electrode connected to a power supply means, a cap disposed to cover the electrode and detachable from the base, the microneedle provided in the cap with its tip exposed to the outside, and a fluid holding portion incorporated in the cap for holding the fluid to be supplied to the microneedle, wherein the fluid holding portion is disposed so as to come into contact with the electrode when the cap is attached to the base. This configuration allows for easy repeated use of the fluid delivery device.

[0027] The fluid delivery device 100 may include a cover member that covers the cap portion 120. This can prevent liquid leakage through the microneedles 130 and prevent unintended contact with biological tissue. The cover member is preferably shaped to cover at least the entire surface on which the microneedles 130 are provided.

[0028] The cap portion 120 of the fluid delivery device 100 may have a transparent portion for visually checking the remaining amount of medicinal liquid or the like held in the fluid holding portion 140. The transparent portion may be made of, for example, a transparent or translucent resin. The transparent portion may be provided corresponding to each of the first fluid holding portion 140a and the second fluid holding portion 140b.

[0029] In this example, the mechanism is such that electricity is automatically applied when the microneedles 130 of the fluid delivery device 100 are pressed against biological tissue, but the present invention is not limited to this, and a power switch for setting whether electricity is applied or not may be provided on the base unit 110. When the power switch is in the off state, electricity is prevented from being applied even when the microneedles 130 are pressed against biological tissue.

[0030] Figure 5 is a conceptual diagram illustrating the principle of operation of a fluid delivery device. Device 10 in Figure 5 has first transporter 11, second transporter 12, positive microneedle 13, negative microneedle 14, and current / voltage application means 15.

[0031] The first transporter 11 is elongated and has a first transport flow path (not shown) extending from one end to the other end thereof. The first transporter 11 is configured to allow a first fluid 21 to flow through the first transport flow path. The second transporter 12 is elongated and has a second transport flow path (not shown) extending from one end to the other end thereof. The second transporter 12 is configured to allow a second fluid 22 to flow through the second transport flow path. The first transporter 11 and the second transporter 12 may be configured separately from each other, or may be provided integrally.

[0032] The first fluid 21 flowed through the first transport channel and the second fluid 22 flowed through the second transport channel may be any fluid to be injected into a subject, but when the subject is skin or tissue inside a living body, it is preferable that the first fluid 21 and the second fluid 22 are fluids containing a drug. The first fluid 21 and the second fluid 22 may be different fluids or the same fluid.

[0033] As shown in FIG. 6, the positive microneedle 13 and the negative microneedle 14 are each made of a porous material and have a conical shape. They have a flange 23 around the rear end of the base of the cone. The positive microneedle 13 has at least a first opening (not shown) at its tip and a first flow path (not shown) that has a fixed positive charge and is in communication with the first opening. The negative microneedle 14 has at least a second opening (not shown) at its tip and a second flow path (not shown) that has a fixed negative charge and is in communication with the second opening. The first flow path and the second flow path extend in a network-like manner through the voids in the porous material. In a specific example shown in FIG. 2, the tip ends of the positive microneedle 13 and the negative microneedle 14 have a height of 300 μm, and the flange 23 has a height of 300 μm. It is preferable to provide an elastically deformable insulating wall between the positive microneedle 13 and the negative microneedle 14 that is higher than the height of the microneedles.

[0034] As shown in Figure 5, the positive microneedle 13 is provided at one end of the first transporter 11 so that the first flow path communicates with the first transport flow path. The positive microneedle 13 is provided so that its tip protrudes from one end of the first transporter 11 in the extension direction of the first transporter 11. The negative microneedle 14 is provided at one end of the second transporter 12 so that the second flow path communicates with the second transport flow path. The negative microneedle 14 is provided so that its tip protrudes from one end of the second transporter 12 in the extension direction of the second transporter 12. The positive microneedle 13 and the negative microneedle 14 are arranged adjacent to each other so that their respective tips protrude on the same side.

[0035] The positive microneedle 13 and the negative microneedle 14 may each consist of a plurality of microneedles, as shown in FIG. 6, or may each consist of a single microneedle. When a plurality of microneedles are used, they may form a microneedle array. The positive microneedle 13 and the negative microneedle 14 may each have a pointed tip, as shown in FIG. 2, so that they can be inserted into a target object and directly inject the first fluid 21 and the second fluid 22 into the target object. Alternatively, the tip may be curved or flat, so that they can spread the surface of the target object and allow the first fluid 21 and the second fluid 22 to penetrate into the target object. The first opening and the second opening may each consist of a single opening or a plurality of openings.

[0036] The positive microneedle 13 may be made of any material capable of immobilizing a positive charge in the first flow path, and the negative microneedle 14 may be made of any material capable of immobilizing a negative charge in the second flow path. The positive microneedle 13 and the negative microneedle 14 may be made of, for example, a hydrogel material, a porous resin, an oxide, a metal, a biodegradable material, or the like. More specifically, the positive microneedle 13 may have a higher mobility of anions than cations when a fluid is introduced into the first flow path. For example, the positive microneedle 13 may have a positive charge immobilized on the wall surface of the first flow path, a positive charge embedded in the surface layer, or may be made of a hydrogel containing positively charged functional groups. The negative microneedle 14 may have a higher mobility of cations than anions when a fluid is introduced into the second flow path. For example, the negative microneedle 14 may have a negative charge immobilized on the wall surface of the second flow path, a negative charge embedded in the surface layer, or may be made of a hydrogel containing negatively charged functional groups.

[0037] Here, the hydrogel material refers to a material that forms a hydrogel when dispersed in water (dispersion medium). Examples of hydrogel materials include natural polymers such as agar, gelatin, agarose, xanthan gum, gellan gum, sclerotium gum, gum arabic, tragacanth gum, karaya gum, cellulose gum, tamarind gum, guar gum, locust bean gum, glucomannan, chitosan, carrageenan, quince seed, galactan, mannan, starch, dextrin, curdlan, casein, pectin, collagen, fibrin, peptides, chondroitin sulfates such as sodium chondroitin sulfate, hyaluronic acid (mucopolysaccharides) and hyaluronates such as sodium hyaluronate, alginic acid, sodium alginate, and alginates such as calcium alginate, and derivatives thereof; cellulose derivatives such as methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, and carboxymethylcellulose, and salts thereof; polyacrylic acid, polymethacrylic acid, poly(methylcellulose), ... Examples of suitable polymers include poly(meth)acrylic acids and their salts, such as sodium dimethacrylate and acrylic acid-alkyl methacrylate copolymers; synthetic polymers such as polyvinyl alcohol, polyhydroxyethyl methacrylate, polyacrylamide, poly(N-isopropylacrylamide), polyvinylpyrrolidone, polystyrene sulfonic acid, polyethylene glycol, carboxyvinyl polymers, alkyl-modified carboxyvinyl polymers, maleic anhydride copolymers, polyalkylene oxide resins, crosslinked products of poly(methyl vinyl ether-alt-maleic anhydride) and polyethylene glycol, crosslinked products of polyethylene glycol, N-vinylacetamide crosslinked products, acrylamide crosslinked products, and crosslinked products of starch-acrylate graft copolymers; silicones; interpenetrating network hydrogels and semi-interpenetrating network hydrogels; poly(2-hydroxyethyl methacrylate), poly(2-acrylamido-2-methylpropanesulfonic acid); and mixtures of two or more of these.Among these, from the viewpoints of load-bearing capacity and biocompatibility, preferred materials for constituting the hydrogel are collagen, glucomannan; carboxymethylcellulose, sodium carboxymethylcellulose; polyacrylic acid, sodium polyacrylate; interpenetrating network structure hydrogels, and semi-interpenetrating network structure hydrogels. Furthermore, from the viewpoints of obtaining excellent mechanical strength and excellent biocompatibility, a crosslinked product of poly(methyl vinyl ether-alt-maleic anhydride) and polyethylene glycol is preferred, and further, from the viewpoint of ensuring the electrical neutrality of the hydrogel, crosslinked polyethylene glycol is preferred.

[0038] Furthermore, examples of hydrogel materials having a fixed charge (positive or negative charge) include gel materials in which functional groups having a fixed charge have been introduced into hydrogel materials having no fixed charge, and gel materials that are polymers (polymers) containing monomer units having a fixed charge. Among these, gel materials that are polymers (polymers) containing monomer units having a fixed charge are preferred, and copolymers of a non-charged monomer and a monomer having a fixed charge are more preferred.

[0039] Resins include polycarbonate, acrylonitrile-butadiene-styrene (ABS) resin, phenolic resin, acrylic resin, and methacrylic resin (such as polyglycidyl methacrylate resin). Oxides include inorganic oxides and their derivatives, such as silicon oxide, tin oxide, zirconia oxide, titanium oxide, niobium oxide, tantalum oxide, aluminum oxide, tungsten oxide, hafnium oxide, and zinc oxide. Metals include nickel, iron, and alloys thereof. Biodegradable materials include polylactic acid-glycolic acid copolymer (PLGA), PLGA-based composites, β-tricalcium phosphate, calcium carbonate, polycaprolactone, polydioxanone, hydroxyapatite, polyethylene glycol, and magnesium alloys. The positive microneedle 13 and the negative microneedle 14 may be made of a combination of two or more of the materials listed above.

[0040] The current / voltage application means 15 has a first electrode 24 arranged in the first transport flow path and a second electrode 25 arranged in the second transport flow path, and is configured to be able to apply a current or voltage between the first electrode 24 and the second electrode 25. The first electrode 24 is inserted into the first transport flow path from the other end side of the first transporter 11, and the second electrode 25 is inserted into the second transport flow path from the other end side of the second transporter 12. More specifically, the current / voltage application means 15 is configured to apply a current or voltage with the first electrode 24 as negative and the second electrode 25 as positive. As a result, when current or voltage is applied between the first electrode 24 and the second electrode 25 by the current / voltage application means 15, an ionic current flows through the first fluid 21 in the first flow path and the second fluid 22 in the second flow path, and electroosmotic flow causes the first fluid 21 to flow outward from the first opening and the second fluid 22 to flow outward from the second opening.

[0041] Next, the operation will be described. The fluid delivery device 10 is used as follows. First, the positive microneedle 13 provided at one end of the first transporter 11 and the negative microneedle 14 provided at one end of the second transporter 12 are inserted into or pressed against the skin or tissue inside a living body. In this state, a current or voltage is applied between the first electrode 24 and the second electrode 25 by the current / voltage application means 15. This causes an ionic current to flow through the first fluid 21 in the first flow path and the second fluid 22 in the second flow path, causing the first fluid 21 to flow outward from the first opening of the positive microneedle 13 and the second fluid 22 to flow outward from the second opening of the negative microneedle 14 due to electroosmotic flow. This allows the fluid delivery device 10 to directly inject the first fluid 21 and the second fluid 22 into the subcutaneous tissue or tissue. Therefore, by using fluids containing a drug as the first fluid 21 and the second fluid 22, the drug can be administered more efficiently than with conventional electroosmotic pumps that do not have microneedles.

[0042] The fluid delivery device 10 can control the flow rate of the generated electroosmotic flow by adjusting the current or voltage applied by the current / voltage application means 15, and has excellent control over the amount of discharge of the first fluid 21 and the second fluid 22. Furthermore, in the fluid delivery device 10, the positive side microneedle 13 and the negative side microneedle 14 are adjacent to each other and are arranged so that their tips protrude on the same side, allowing the entire device to be configured compactly and miniaturized. Furthermore, the positive side microneedle 13 and the negative side microneedle 14 can be easily pierced or pressed against a target object simultaneously, making it easy to handle.

[0043] The microneedles may have a sharp tip as shown in Figure 5, or may have a blunt tip as shown in Figures 7 and 8. If the tip is blunt, the tip may have any shape as long as it is formed as a flat surface or a smoothly curved surface, and may be, for example, a truncated cone, truncated pyramid, columnar such as a cylinder or prism, or a shape with a dome-shaped tip.

[0044] As shown in FIG. 8, when a microneedle 130 (13, 14) with a blunt tip is pressed against the skin, it can spread the stratum corneum 1, facilitating molecular permeation and allowing substances such as drugs held in the flow channel 11 to penetrate the stratum corneum 1. The microneedle 130 can also penetrate substances such as drugs into the layer 2 below the stratum corneum 1. When pressed against the skin and a current or voltage is applied between the microneedle 130 and the skin, an ionic current flows, and the fixed charge of the flow channel 131 generates an electroosmotic flow in the flow channel 131. This can improve the penetration efficiency of substances such as drugs. Furthermore, when the flow channel 131 is modified with a polymer, this can promote the movement of relatively large molecules or particles, for example, those with a molecular weight of approximately 500 to 10,000, thereby improving the penetration efficiency of these molecules and particles.

[0045] Although the preferred embodiments of the present disclosure have been described in detail above with reference to the accompanying drawings, the technical scope of the present disclosure is not limited to such examples. It is clear that a person skilled in the art of the present disclosure can conceive of various modified or altered examples within the scope of the technical idea described in the claims, and it is understood that these also naturally fall within the technical scope of the present disclosure.

[0046] Furthermore, the effects described herein are merely descriptive or exemplary and are not limiting. In other words, the technology according to the present disclosure may achieve other effects that will be apparent to those skilled in the art from the description of this specification, in addition to or in place of the above-described effects.

[0047] The following configurations also fall within the technical scope of the present disclosure. (Item 1) A fluid delivery device that delivers a fluid by bringing microneedles into contact with biological tissue, a base portion having an electrode portion connected to a power supply means; a cap portion disposed to cover the electrode portion and detachable from the base portion; The microneedle is provided in the cap portion and has a tip exposed to the outside; a fluid holding portion that is built into the cap portion and holds a fluid to be supplied to the microneedle; Equipped with The fluid delivery device is arranged so that the fluid holding portion contacts the electrode portion when the cap portion is attached to the base portion. (Item 2) the electrode unit has a first electrode and a second electrode, Item 1. The fluid delivery device according to item 1, wherein the fluid holding portion has a first fluid holding portion in contact with the first electrode and a second fluid holding portion in contact with the second electrode. (Item 3) The microneedle is a first microneedle for discharging fluid from the first fluid holding portion; Item 3. The fluid delivery device of item 2, comprising: a second microneedle for delivering fluid from the second fluid holding portion. (Item 4) Item 4. The fluid delivery device according to item 3, wherein an insulating wall protruding from the cap portion is provided between the first microneedle and the second microneedle. (Item 5) Item 5. The fluid delivery device according to item 4, wherein the tip of the insulating wall protrudes from the cap portion further than the microneedle. (Item 6) 5. The fluid delivery device according to item 4, wherein the insulating wall is configured to be pressed against the biological tissue and elastically deformed when the microneedle is brought into contact with the biological tissue. (Item 7) Item 2. The fluid delivery device according to item 1, wherein the first fluid holding portion and the second fluid holding portion are respectively arranged in a first accommodating space and a second accommodating space formed in the cap portion. (Item 8) Item 10. The fluid delivery device of item 1, wherein the base portion includes a grip portion that is gripped by a user during use. (Item 9) Item 10. The fluid delivery device of item 1, wherein the fluid holding portion is configured to be replaceable by removing the cap portion from the base portion. [Explanation of symbols]

[0048] 100 Fluid delivery device 110 Base 111 Electrode section 120 Cap part 130 Microneedles 140 Fluid holding part 150 Insulated Wall

Claims

1. A fluid delivery device that delivers a fluid by bringing microneedles into contact with biological tissue, a base portion having an electrode portion connected to a power supply means; a cap portion disposed to cover the electrode portion and detachable from the base portion; The microneedle is provided in the cap portion and has a tip exposed to the outside; a fluid holding portion that is built into the cap portion and holds a fluid to be supplied to the microneedle; Equipped with the cap is disposed so that the fluid holding portion is in contact with the electrode portion when the cap is attached to the base portion; the electrode portion has a first electrode and a second electrode, the fluid holding portion has a first fluid holding portion in contact with the first electrode and a second fluid holding portion in contact with the second electrode, The microneedle is a first microneedle for delivering fluid from the first fluid holding portion; a second microneedle for delivering fluid from the second fluid holding portion; an insulating wall protruding from the cap portion is provided between the first microneedle and the second microneedle; The fluid delivery device is configured such that when the microneedle is brought into contact with biological tissue, the insulating wall is pressed against the biological tissue and elastically deforms, thereby causing the microneedle to come into contact with the biological tissue.

2. The fluid delivery device according to claim 1 , wherein a tip of the insulating wall protrudes from the cap portion further than the microneedle.

3. A fluid delivery device as described in claim 1, wherein the insulating wall is made of a water-repellent material.

4. A fluid delivery device as described in claim 3, wherein the insulating wall is arranged to surround the first microneedle and the second microneedle, respectively.

5. A fluid delivery device as described in claim 1, wherein the fluid holding portion is an absorbent body capable of soaking in liquid or gel-like fluid.

6. A notification means for indicating that power supply from the power supply means has started, The fluid delivery device according to claim 1 , wherein the energization is initiated by bringing the microneedles into contact with biological tissue, and power is supplied from the power supply means to the notification means.

7. the first fluid holding portion and the second fluid holding portion are disposed in a first accommodating space and a second accommodating space formed in the cap portion, respectively; The fluid delivery device of claim 1 , wherein the fluid retaining portion is configured to be replaceable by removing the cap portion from the base portion.

8. The fluid delivery device of claim 1 , wherein the base portion includes a grip portion that is gripped by a user during use.

9. A fluid delivery device as described in Claim 6, wherein the notification means not only notifies that current flow has started, but also notifies after a predetermined time has elapsed since current flow started.

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