A device that stimulates tear production

Abstract

To provide a device that enables efficient tear fluid collection with less stress on the subject.SOLUTION: An embodiment of the present disclosure provides a device for stimulating tear secretion including a container body including a rim capable of coming into close contact with a face in a region around an eye, the container body defining therein a gas-receiving space capable of being filled with gas generated by an eye irritant.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present disclosure relates to devices for increasing tear production. [Background technology]

[0002] One method for collecting tears is, for example, to have a test paper pressed against the surface of the eyeball and absorb the tears.

[0003] It is necessary to collect tears efficiently. However, the method of pressing a test paper against the surface of the eyeball can cause irritation and pain to the eyeball. In addition, tear secretion cannot be freely controlled by the subject's will, and collecting a sufficient amount of tears can take time. For this reason, collecting tears can be a burden for the subject. It is necessary to collect tears efficiently while minimizing the burden on the subject. Summary of the Invention

[0004] Here, for example, but not by way of limitation, there is recognized a need for efficient collection of tear fluid while minimizing the burden on the subject.

[0005] Some embodiments of the present disclosure provide a device for causing tear secretion. In some embodiments, the device includes a container body. In some embodiments, the container body has a rim that can fit tightly against the face around the periphery of the eye. In some embodiments, the container body defines a gas-supplied space. In some embodiments, the gas-supplied space can be filled with gas generated from an ocular irritant.

[0006] According to the above embodiment, for example, tear collection can be performed efficiently while minimizing the burden on the subject.

[0007]

[0013] Further aspects and advantages of the present disclosure will become readily apparent to those skilled in the art from the following detailed description, wherein only illustrative embodiments of the present disclosure are shown and described. As will be realized, the present disclosure is capable of other and different embodiments, and its several details are capable of modifications in various obvious respects, all without departing from the present disclosure. Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive. [Brief explanation of the drawings]

[0008] [Figure 1] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 2] FIG. 2 is a view of the device according to the embodiment of FIG. 1 as seen from the opening side. [Figure 3] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 4] 4 is a view of the device according to the embodiment of FIG. 3 as seen from the opening side. [Figure 5] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 6] 6 is a view of the device according to the embodiment of FIG. 5 as seen from the opening side. [Figure 7] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 8] 8 is a view of the device according to the embodiment of FIG. 7 as seen from the opening side. [Figure 9] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 10] 10 is a view of the device according to the embodiment of FIG. 9 as seen from the opening side. [Figure 11] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 12] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 13] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 14] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 15]FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 16] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 17] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 18] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 19] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 20] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 21] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 22] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0009] In some embodiments, the device secretes tears. The device may or may not collect the secreted tears.

[0010] In some embodiments, when the device does not collect the tears secreted by the device, the tears secreted by the device may be collected by another collection means. The other collection means may be, for example, a container that collects the tears that drop from the eye, or a member other than a container. The other collection means may be, for example, a dropper that collects the tears by sucking them from the eye, or a member other than a dropper.

[0011] In some embodiments, the tear fluid is secreted from the eye of a subject, which in some embodiments may include or be a human.

[0012] In some embodiments, the subject may include or be a non-human animal. The non-human animal may include or be a mammal. The non-human animal may be, for example, but not limited to, a working animal, a livestock animal, a pet animal, or a wild animal.

[0013] In some embodiments, the device comprises a reservoir body. In some embodiments, the reservoir body has a rim that can be fitted to the face around the periphery of the eye. In some embodiments, when tearing, the reservoir body fits the rim to the face around the periphery of the subject's eye.

[0014] As used herein, the term "periphery of the eye" generally refers to a region of the face located at the periphery of the eye. In some embodiments, the periphery of the eye may include, for example, one or more of the region nasal to the inner corner of the eye, the region lateral to the temporal side of the outer corner of the eye, the upper eyelid, the region above the upper eyelid, the lower eyelid, and the region below the lower eyelid. In some embodiments, when the subject's head is oriented to produce tears from the eyes, the face with which the edge can be in close contact may include or may be a region below the subject's eyes.

[0015] In some embodiments, the container body defines a gas-supplied space. In some embodiments, the device may include a gas-supplied space formed within the container body, into which gas generated from the ocular irritant is supplied.

[0016] As used herein, the term "gas-supplied space" generally refers to a space that can be filled with gas generated from an ocular irritant.

[0017] In some embodiments, the eye irritant may be one that generates a gas that irritates the eye, thereby causing the eye to produce tears. In some embodiments, the eye irritant may include one of the substances that react to generate its components, or may be one of the substances that react to generate its components.

[0018] In some embodiments, the active ingredient of the ocular irritant may include or be a lachrymatory ingredient or factor. In some embodiments, the ocular irritant may include or be a part (or parts) of multiple substances necessary to produce a lachrymatory substance.

[0019] In some embodiments, the active ingredient of the ocular irritant may include a naturally occurring substance, or may be a naturally occurring substance. In some embodiments, the active ingredient of the ocular irritant may include a substance extracted from a plant of the Allium genus, or may be a substance extracted from a plant of the Allium genus. The Allium genus plant may be, for example, but not limited to, onion (Allium cepa), leek (Allium fistulosum), garlic (Allium sativum), Sicilian garlic (Allium siculum), etc., or may include one or more thereof.

[0020] In some embodiments, the active ingredient of the ocular irritant may include, or may be, an artificially synthesized substance. In some embodiments, the ocular irritant may include, or may be, a chemical substance. In some embodiments, the ocular irritant may include, or may be a tear gas or lachrymatory agent. In some embodiments, the ocular irritant may be volatile. In some embodiments, the ocular irritant may include, or may be an eye irritant component. In some embodiments, the ocular irritant may include, benzyl bromide (benzyl bromide, α-bromotoluene, bromomethylbenzene). In some embodiments, the ocular irritant may be, or may be, benzyl chloride (α-chlorotoluene, chloromethylbenzene), or may include one or more thereof.

[0021] In some embodiments, the active ingredient of the eye irritant may include a compound having a structure called thioalkanal S-oxide at the end of the alkyl chain, or an analogous compound thereof. In some embodiments, the active ingredient of the eye irritant may be a compound represented by R-CH=SO. This may include, for example, but is not limited to, thioethanal S-oxide (R=C1), thiopropanal S-oxide (R=C2), thiobutanal S-oxide (R=C3), and thiohexanal S-oxide (R=C4).

[0022] In some embodiments, the ocular irritant may include syn-propanethial-S-oxide (also referred to as CHOS, Thiopropanal S-Oxide, or 1-Sulfinylpropane), or may be syn-propanethial-S-oxide. In some embodiments, the ocular irritant may include a substance that synthesizes syn-propanethial-S-oxide, or may be a substance that synthesizes syn-propanethial-S-oxide. In some embodiments, the ocular irritant may generate syn-propanethial-S-oxide by reacting a substance during use.

[0023] In some embodiments, for example, an enzyme such as allinase (dry and supported on cellulose) may be used to decompose a sulfoxide amino acid (substrate) to generate sulfenic acid. In some embodiments, lachrymatory factor synthase (LFS) may be used to convert the resulting 1-propenesulfenic acid to syn-propanethial-S-oxide. In some embodiments, allinase and LFS may be placed in a container. In some embodiments, these enzymes may be supported on a support material in a dry state and placed in the container.

[0024] In some embodiments, for example, to generate syn-propanethial-S-oxide, one or more of trans-1-propenyl-L-cysteine ​​sulfoxide (PRENCSO), allinase, and LFS may be used. In some embodiments, for example, one or more of PRENCSO, allinase, and LFS may be held inside a container, and the remainder may be reacted with them upon use.

[0025] In some embodiments, for example, the active ingredient of the ocular irritant may include or be syn-butanethial S-Oxide, C4H8OS.

[0026] In some embodiments, various other tear gases may be used, for example, as eye irritants. Tear gas may be used within the scope of safety. For example, tear gas may be diluted. For example, tear gas may be modified to enhance safety. Tear gas may be, for example, but not limited to, an emetic such as adamsite; a sneezing agent such as diphenylcyanoarsine (DC) or diphenylchloroarsine (DA); or a lachrymator such as bromobenzyl cyanide, chloroacetophenone, chlorobenzylidenemalononitrile, or dibenzo-1,4-oxazepine, or may contain one or more of these. The tear gas may be pepper spray or may contain its main ingredient, capsaicin (also known as oleoresin capsicum, or OC agent).

[0027] In some embodiments, the device may further include a fibrous tissue that carries the ocular irritant and is disposed in the irritant placement portion. Examples of fibrous tissue that carries the ocular irritant include, but are not limited to, cellulose, gauze, nonwoven fabric, and sponge. The fibrous tissue that carries the ocular irritant may have various shapes. Examples of shapes include, but are not limited to, circular, sheet, string, circular, and spherical. As an example, the fibrous tissue may be formed into a cotton-like or fluffy form. This may increase the effective surface area, improving the volatilization efficiency of the lachrymatory component and the penetration efficiency of the substrate liquid. In some embodiments, the ocular irritant may be in liquid form and sealed in the bag. In some embodiments, the fibrous tissue that carries the ocular irritant may not be provided, and the components of the ocular irritant may be held in a dry state within the container body. In some embodiments, the ocular irritant may be prepared in a solid form, such as a tablet or powder. For example, the ocular irritant may be provided in a mixed state with an excipient.

[0028] In some embodiments, the ocular irritant may include at least a portion of an enzyme and a substrate that react to generate a gas, or may be an enzyme and a substrate that react to generate a gas. In some embodiments, the enzyme may be disposed in a dry state in the irritant disposition portion, and the substrate may be added to the enzyme in a solution state. In some embodiments, the enzyme may be allinase and lachrymatory factor synthase (LFS). In some embodiments, the substrate may be PRENCSO. In some embodiments, at the time of use, a solution of the substrate PRENCSO may be added dropwise to the enzyme. These may react to generate the active ingredient of the ocular irritant.

[0029] In some embodiments, the container body may be cup-shaped with an opening, or may not be cup-shaped with an opening. In some embodiments, if the container body is not cup-shaped, the container body may be, for example, plate-shaped, dish-shaped with a concave surface inside the outer edge, cylindrical with a bottom, or the like, as long as it can receive tear fluid. In some embodiments, the container body may include a bottom disposed on the other side in the first direction and a peripheral wall rising from the peripheral edge of the bottom to one side in the first direction.

[0030] In some embodiments, the container body may have an opening in one direction in the first direction, or in a direction other than the first direction. As used herein, the term "first direction" generally refers to the opening direction of the container body.

[0031] In some embodiments, when the container body has an opening, the rim may be formed continuously around the entire periphery, or may be formed only around a portion of the opening. In some embodiments, the container body may form a substantially closed space between the eye and the rim when worn with the rim tightly attached to the face around the eye, or may not form a closed space. In some embodiments, a container body that does not form a substantially closed space between the eye and the rim may form a partially open space between the eye and the rim.

[0032] In some embodiments, the device may further include an irritant placement portion that communicates with the gas-supplied space and in which an ocular irritant is placed, or may not include an irritant placement portion. In some embodiments, the irritant placement portion may be formed in at least a portion of the gas-supplied space, or may not be formed in at least a portion of the gas-supplied space. In some embodiments, the irritant placement portion may be formed separately from the gas-supplied space. In some embodiments, the irritant may be placed in a position closest to the user's iris or pupil when the device is in use. This is said to be the area on the eye that has the greatest tear-inducing effect. For example, the irritant placement portion may be defined substantially at the center of the bottom of the container, or may be defined at or near the center of the container's volume.

[0033] In some embodiments, the container body may further include a tear reservoir for collecting tears secreted from the eye, or may not include a tear reservoir.

[0034] In some embodiments, the container body may include a partition wall that separates the interior thereof into a gas supply portion and a tear fluid storage portion, or may not include a partition wall. In some embodiments, if a partition wall is not included, the gas supply portion and the tear fluid storage portion may be disposed inside the container body without being separated.

[0035] In some embodiments, when the gas supply portion and the tear fluid storage portion are disposed without being partitioned inside the container body, the stimulant placement portion may be formed on the bottom of the container body, or may be formed somewhere other than the bottom of the container body. In some embodiments, the stimulant placement portion may be formed to be disposed on the bottom. In some embodiments, when the stimulant placement portion is formed on the bottom of the container body, the bottom may be inclined toward the other side in the first direction from a bottom intermediate portion between a first end of the container body located on the outer corner of the eye and a second end located on the inner corner of the eye toward the first end and the second end when the container is worn with its edge in close contact with the face in the peripheral area of ​​the eye, or the bottom may not be inclined.

[0036] In some embodiments, the stimulant placement portion may be formed on the second end side of the bottom intermediate portion, or may not be formed on the second end side. In some embodiments, when the bottom includes a platform portion that protrudes from the periphery of the bottom toward the inside of the bottom on one side in the first direction, the stimulant placement portion may be formed on the platform portion, or may not be formed on the platform portion. In some embodiments, the bottom is detachable from the peripheral wall, and the stimulant placement portion may be disposed on the bottom portion, or may be disposed somewhere other than the bottom portion.

[0037] In some embodiments, the stimulant placement portion may be formed on the inner circumferential surface of the peripheral wall, or may not be provided on the inner circumferential surface of the peripheral wall. In some embodiments, the stimulant placement portion may include a holder body that holds the ocular stimulant, and a connecting member having one end connected to the holder body and the other end connected to the container body. In some embodiments, the container body may include a detachable member that is detachable from its opening, and the stimulant placement portion may be located on a surface of the detachable member that faces the inside of the container body when the detachable member is attached to the opening.

[0038] In various embodiments, the bottom portion may be configured to be detachably attached to the peripheral wall. For example, the bottom portion and the peripheral wall may each have a magnet and be configured to be detachably attached. Examples of detachable attachment between the bottom portion and the peripheral wall include, but are not limited to, magnets, double-sided tape, Velcro, snap-in, hooking, and insertion (e.g., sliding a portion of the bottom portion into a slit in the peripheral wall). Other embodiments may also be used.

[0039] In some embodiments, the partition wall may be disposed between a first end located on the outer corner of the eye and a second end located on the inner corner of the eye when the container is worn with its edge in close contact with the face around the eye, and may divide the interior of the container body into a first compartment on the first end side and a second compartment on the second end side; the partition wall may not divide the interior of the container body into a first compartment and a second compartment. In some embodiments, when the partition wall divides the interior of the container body into a first compartment and a second compartment, the first compartment may form the tear storage compartment, and the second compartment may form the gas supply space. In some embodiments, the first compartment may form the gas supply space, and the second compartment may form the tear storage compartment.

[0040] In some embodiments, the partition wall is disposed between an upper end of the container body located on the upper eyelid side and a lower end of the container body located on the lower eyelid side when the container is worn with its edge in close contact with the face around the eye, and may divide the interior of the container body into an upper compartment on the upper end side and a lower compartment on the lower end side, or the partition wall may not divide the interior of the container body into an upper compartment and a lower compartment. In some embodiments, when the partition wall divides the interior of the container body into an upper compartment and a lower compartment, the upper compartment may form the tear storage compartment, and the lower compartment may form the gas supply space. In some embodiments, the upper compartment may form the gas supply space, and the lower compartment may form the tear storage compartment.

[0041] In some embodiments, the entire periphery of the outer peripheral edge of the partition wall is joined to the inner peripheral surface of the container body, forming a sealed space between the partition wall and the inner peripheral surface of the container body, and the sealed space forms the stimulant placement portion, and the partition wall may have an air vent communicating with both surfaces thereof.

[0042] In some embodiments, the partition wall may be formed in a cylindrical shape rising from the bottom to one side in the first direction, and the stimulant placement portion may be positioned inside the cylindrical partition wall.

[0043] In some embodiments, the partition wall may be disposed at an intermediate position in the first direction of the peripheral wall, in a plane direction intersecting the first direction, to partially partition the internal space of the container body. In some embodiments, when the partition wall partially partitions the internal space of the container body, the stimulant disposing portion may be disposed on the bottom side of the partition wall in the first direction, and the tear fluid containing portion may be formed on the opposite side of the partition wall from the bottom in the first direction. In some embodiments, when the partition wall partially partitions the internal space of the container body, the stimulant disposing portion may be disposed on the opposite side of the partition wall from the bottom in the first direction, and the tear fluid containing portion may be formed on the bottom side of the partition wall in the first direction. In some embodiments, the partition wall is formed to have a communication portion that connects the internal space of the container body to the opposite side from the bottom side in the first direction, and the communication portion may be disposed on the inner corner side of the eye when the rim of the container body is worn in close contact with the face in the peripheral area of ​​the eye. In some embodiments, the communication portion may be disposed on the outer corner side of the eye when the rim of the container body is worn in close contact with the face in the peripheral area of ​​the eye. In some embodiments, the partition wall may be inclined from the communication portion toward the peripheral wall in the first direction toward the bottom side, or may not be inclined. In some embodiments, the partition wall may be inclined from the communication portion toward the peripheral wall in the first direction toward the opposite side from the bottom side.

[0044] In some embodiments, the device may include a tear reservoir that is integral with the container body and collects the tear fluid contained in the tear reservoir, or may not include a tear reservoir. In some embodiments, the tear reservoir may be formed in a bottomed cylindrical shape extending outward from an opening of the container body, or may not be formed in a bottomed cylindrical shape. In some embodiments, if the tear reservoir is not formed in a bottomed cylindrical shape, the tear reservoir may be, for example, without limitation, in a hollow spherical shape or a hollow box shape having an opening that communicates with the container body. In some embodiments, the tear reservoir may not be formed integrally with the container body. In some embodiments, the tear reservoir may be formed separately from the container body. In some embodiments, if the tear reservoir is formed separately from the container body, it may further include a connecting tube that connects the container body and the tear solution. In some embodiments, the tear reservoir may be configured so that the tear solution can be transferred from the container body to a tear reservoir that is formed separately from the container body.

[0045] In some embodiments, the tear container formed integrally with the container body may be positioned on the outer corner of the eye relative to the container body when the edge is in close contact with the face, around the periphery of the eye, and the tear container may have a container opening that opens on the inner corner of the eye. In some embodiments, the tear container formed integrally with the container body may be positioned at a position other than the outer corner of the eye relative to the container body when the edge is in close contact with the face, around the periphery of the eye. In some embodiments, the tear container may have a container opening that opens in a direction other than the inner corner of the eye. In some embodiments, the tear container may have a container opening that opens inward of the container body.

[0046] In some embodiments, the container body may have an access opening that allows access to the interior of the container body from the exterior when the container body is worn with its rim tightly against the face around the periphery of the eye, for example, but not limited to, the access opening for collecting tears or injecting ocular irritants.

[0047] In some embodiments, at least a portion or all of the container body may be formed from a transparent material that allows the interior to be optically confirmed from the outside of the container body. The transparent material that allows the interior to be optically confirmed from the outside of the container body may be, for example, but not limited to, a resin-based material or a glass-based material. In some embodiments, the transparent material that allows the interior to be optically confirmed from the outside of the container body may have transparency that allows the amount of tear fluid accumulated inside the container body to be confirmed from the outside of the container body visually or with a camera. In some embodiments, a camera may be disposed inside the container body. In some aspects, the required light may be incident from the outside of the container to the interior. In some aspects, the required light may be emitted inside the container body.

[0048] In some embodiments, the device may include two container bodies. In some embodiments, the device may include a connector connecting the inner-corner ends of the two container bodies, which are positioned closer to the inner corners of the eyes when the two container bodies are worn with their edges in close contact with the face around the periphery of the eyes. In some embodiments, the device may further include a fastener that can fasten the container bodies to the subject's head so that the edges are in close contact with the face around the periphery of the eyes. In some embodiments, each of the two container bodies may further include a fastener that is provided at the outer-corner end that is positioned closer to the outer corners of the eyes when the two container bodies are worn with their edges in close contact with the face around the periphery of the eyes, and that can fasten the container bodies to the subject's head. For example, but not limited to, the fastener may be shaped like a temple for glasses so that the glasses can be hung on the subject's ears, or like a band so that the glasses can be worn around the back of the subject's head.

[0049] A device 100A according to an embodiment is shown in Figures 1 and 2. The device 100A shown in Figures 1 and 2 includes a container body 10A and a partition wall 20A.

[0050] The container body 10A includes a bottom 11 and a peripheral wall 12. The container body 10A has an opening 13 that opens toward one side Da1 in the first direction Da. The container body 10A is made of a transparent material that allows the interior of the container body 10A to be optically confirmed from the outside, such as a transparent or translucent resin material.

[0051] The bottom 11 is disposed on the other side Da2 of the first direction Da in the container body 10A. The first direction Da is the direction in which the opening 13 opens. The first direction Da is the direction connecting the opening 13 and the bottom 11. The bottom 11 is, for example, plate-shaped and disposed along a plane intersecting (substantially perpendicular to) the first direction Da. The bottom 11 is formed in an elliptical shape when viewed from the first direction Da. The elliptical bottom 11 has a second direction Db perpendicular to the first direction Da as its major axis direction. The bottom 11 has a third direction Dc perpendicular to the first direction Da and the second direction Db as its minor axis direction. The bottom 11 may have an oval, circular, polygonal, or other shape when viewed from the first direction Da.

[0052] The peripheral wall 12 is formed to rise from the peripheral direction of the bottom 11 to one side Da1 in the first direction Da. The peripheral wall 12 is formed in a cylindrical shape extending in the first direction Da. The peripheral wall 12 is formed so that the inner diameter gradually increases from the bottom 11 to the other side Da2 in the first direction Da toward the one side Da1. The peripheral edge 125 of the peripheral wall 12 at the end on the one side Da1 in the first direction Da increases in diameter in a flared (morning-glory) shape toward the one side Da1 in the first direction Da. The peripheral edge 125 of the peripheral wall 12 is formed with a rim 15. The rim 15 is formed so that it can be closely attached to the face at the periphery of the subject's eye when the device 100A is used. When the container body 10A is worn with the rim 15 in close contact with the face at the periphery of the eye 1000, a substantially closed space is formed between the container body 10A and the eye 1000. The rim 15 does not have to completely adhere to the face at the periphery of the eye 1000 to form a completely closed space. As long as tears can be collected by the container body 10A, there may be a small gap between the rim 15 and the face at the periphery of the eye 1000.

[0053] As shown in FIG. 2 , the container body 10A is used with the rim 15 in close contact with the face at the periphery of the subject's eye 1000. The second direction Db of the container body 10A is oriented substantially along a direction connecting the inner corner 1001 side and the outer corner 1002 side of the subject's eye 1000. The container body 10A has a first end 101 and a second end 102. The first end 101 is located on the inner corner 1001 side when the container is worn with the rim 15 in close contact with the face at the periphery of the eye 1000. The second end 102 is located on the outer corner 1002 side when the container is worn with the rim 15 in close contact with the face at the periphery of the eye 1000.

[0054] The partition wall 20A divides the interior of the container body 10A into multiple spaces. The partition wall 20A is disposed between the first end 101 and the second end 102. The partition wall 20A is disposed in the intermediate portion between the first end 101 and the second end 102 in the second direction Db. The partition wall 20A may be disposed in a position shifted toward the first end 101 or the second end 102 from the intermediate portion between the first end 101 and the second end 102 in the second direction Db. The partition wall 20A is disposed in a plane direction substantially perpendicular to the second direction Db. The outer edges of the partition wall 20A are joined to the bottom 11 and the peripheral wall 12 of the container body 10A. The partition wall 20A divides the interior of the container body 10A into a first compartment 111 on the first end 101 side and a second compartment 112 on the second end 102 side.

[0055] A gas supply space 70A and a tear fluid storage section 80A are arranged inside container body 10A. Partition wall 20A divides the interior of container body 10A into gas supply space 70A and tear fluid storage section 80A. In the present disclosure, first section 111 forms gas supply space 70A. Second section 112 forms tear fluid storage section 80A.

[0056] Gas supply space 70A is defined by container body 10A. A stimulant placement section 60A is disposed within container body 10A. An eye stimulant 90 is disposed in stimulant placement section 60A. In the present disclosure, eye stimulant 90 is disposed within gas supply space 70A. As a result, stimulant placement section 60A is formed in at least a portion of gas supply space 70A. Therefore, stimulant placement section 60A is in communication with gas supply space 70A.

[0057] The eye irritant 90 stimulates the eyes and generates a gas that causes the eyes to secrete tears. The eye irritant 90 generates a component that causes the eyes to secrete tears through a reaction.

[0058] In an embodiment of the present disclosure, the active ingredient of the eye irritant 90 includes a substance extracted from a plant of the Allium genus, which is a naturally occurring substance. In an embodiment of the present disclosure, the eye irritant 90 includes, for example, allinase, which is a type of enzyme, and LFS. The eye irritant 90 is supported in a dry state on, for example, cellulose as a fibrous tissue 91.

[0059] In an embodiment of the present disclosure, the ocular stimulant 90 is PRENCSO as a substrate carried by a fibrous tissue 91 in a dry state.

[0060] The enzyme in the eye irritant 90 reacts with the substrate solution (aqueous solution) to produce syn-propanethial-S-oxide, which in turn produces gas containing syn-propanethial-S-oxide that irritates the eye and induces tear production.

[0061] In some embodiments, a mixture of the substrate and the enzyme may be provided and water may be added thereto. In some embodiments, the ocular irritant 90 may include the enzyme and the substrate.

[0062] To collect tears from a subject's eye using device 100A, ocular irritant 90 is placed in irritant placement section 60A of container body 10A. The ocular irritant 90 may be pre-fixed to the inner circumferential surface of container body 10A, for example, with an adhesive. When a substrate solution or water is dripped onto the ocular irritant 90 in container body 10A, gas generated from the ocular irritant 90 fills gas supply space 70A. With opening 13 of container body 10A facing the subject's eye 1000, rim 15 is brought into close contact with the face around the periphery of eye 1000. The subject tilts their head so that the outer corner 1002 of eye 1000, against which container body 10A is pressed, is downward relative to inner corner 1001.

[0063] The gas in gas supply space 70A stimulates eye 1000 by contacting the subject's eyeball. This causes tears to be secreted from eye 1000. The secreted tears flow out of eye 1000 from the lower outer corner 1002 side of the eye. The flowing tears flow into tear storage section 80A of container body 10A. In this way, tears are collected by container body 10A. Partition wall 20A within container body 10A prevents the collected tears from flowing toward stimulant placement section 60A, where ocular stimulant 90 is placed.

[0064] The device 100A described above can collect tears without directly pressing a test paper against the subject's eyeball. The device 100A stimulates the eye 1000 with gas generated from the ocular stimulant 90 to secrete tears. This allows for efficient secretion of tears. The device 100A brings the edge 15 of the container body 10A into close contact with the face around the periphery of the eye. This prevents the gas generated from the ocular stimulant 90 from diffusing to the surroundings. Therefore, the gas generated from the ocular stimulant 90 can efficiently stimulate the eye 1000. The device 100A prevents the tears secreted from the eye 1000 from leaking out of the container body 10A. Therefore, the device 100A allows for efficient collection of tears while minimizing the burden on the subject.

[0065] 3 and 4 show a device 100B according to an embodiment. In the following description, components common to the device 100A shown in FIGS. 1 and 2 are denoted by the same reference numerals as in FIGS. 1 and 2, and descriptions thereof will be omitted.

[0066] The device 100B shown in FIGS. 3 and 4 includes a container body 10B and a partition wall 20B.

[0067] The container body 10B has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15.

[0068] The partition wall 20B divides the interior of the container body 10B into multiple spaces. The partition wall 20B is disposed between the upper end 103 and the lower end 104. The partition wall 20B is disposed in the middle between the upper end 103 and the lower end 104 in the third direction Dc. The partition wall 20B may be disposed in a position shifted toward the upper end 103 or the lower end 104 from the middle between the upper end 103 and the lower end 104 in the third direction Dc. The partition wall 20B is disposed in a plane direction substantially perpendicular to the third direction Dc. The outer edges of the partition wall 20B are joined to the bottom 11 and the peripheral wall 12 of the container body 10B. The partition wall 20B divides the interior of the container body 10B into an upper compartment 121 on the upper end 103 side and a lower compartment 122 on the lower end 104 side.

[0069] A gas supply space 70B and a tear fluid storage portion 80B are arranged inside container body 10B. Partition wall 20B divides the interior of container body 10B into gas supply space 70B and tear fluid storage portion 80B. In the present disclosure, upper compartment 121 forms gas supply space 70B. Lower compartment 122 forms tear fluid storage portion 80B.

[0070] Gas supply destination space 70B is defined by container body 10B. A stimulant placement section 60B is disposed within container body 10B. An eye stimulant 90 is disposed in stimulant placement section 60B. In the present disclosure, eye stimulant 90 is disposed within gas supply destination space 70B. As a result, stimulant placement section 60B is formed in at least a portion of gas supply destination space 70B. Therefore, stimulant placement section 60B is in communication with gas supply destination space 70B.

[0071] To collect tears from a subject's eye 1000 using device 100B, container body 10B is placed with rim 15 in close contact with the face around the periphery of eye 1000. Upper end 103 is positioned on the upper eyelid 1003 side. Lower end 104 is positioned on the lower eyelid 1004 side.

[0072] The gas in gas supply space 70B generated by ocular stimulant 90 stimulates the subject's eye 1000. This causes tears to be secreted from eye 1000. The secreted tears flow out of eye 1000. The flowing tears flow into tear storage section 80B of container body 10B. In this way, tears are collected by container body 10B. Partition wall 20B within container body 10B prevents the collected tears from flowing toward stimulant placement section 60B where ocular stimulant 90 is placed.

[0073] The device 100B described above makes it possible to efficiently collect tears while minimizing the burden on the subject.

[0074] 5 and 6 show a device 100C according to an embodiment. In the following description, components common to the device 100A shown in FIGS. 1 and 2 are denoted by the same reference numerals as in FIGS. 1 and 2, and descriptions thereof will be omitted.

[0075] The device 100C shown in FIGS. 5 and 6 includes a container body 10C and a partition wall 20C.

[0076] The container body 10C has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15.

[0077] The partition wall 20C divides the interior of the container body 10C into multiple spaces. The partition wall 20C is disposed inward of the inner peripheral surface of the container body 10C. The entire circumference of the outer peripheral edge 21 of the partition wall 20C is joined to the container body 10C. The bottom outer peripheral edge 211 of the partition wall 20C is curved in an arc shape when viewed from the first direction Da. The bottom outer peripheral edge 211 is joined to the bottom 11 at a position away from the inner peripheral surface 114 of the peripheral wall 12 on the first end 101 side toward the second side Db2 in the second direction Db. In the partition wall 20C, side outer peripheral edges 212 located on both sides of the peripheral wall 12 in the circumferential direction are joined to the inner peripheral surface of the peripheral wall 12 on the first end 101 side. The partition wall 20C is formed so that its circumferential width gradually decreases from the other side Da2 toward one side Da1 in the first direction Da. An enclosed space 131 is formed between the partition wall 20C and the inner peripheral surface 114 of the peripheral wall 12 on the first end 101 side. The partition wall 20C divides the interior of the container body 10C into the enclosed space 131 and an open space 132. The open space 132 is open to one side Da1 in the first direction Da by the opening 13.

[0078] Partition wall 20C has vent holes 220 that communicate with both sides thereof. For example, two vent holes 220 are arranged in partition wall 20C, one on each side in the circumferential direction of peripheral wall 12. The number of vent holes 220 is not limited to two. The number of vent holes 220 may be one, or three or more. The position of vent hole 220 is not specifically limited as long as it communicates with gas supply space 70C within container body 10C.

[0079] A stimulant-disposing portion 60C is disposed within the container body 10C. An eye stimulant 90 is disposed in the stimulant-disposing portion 60C. The stimulant-disposing portion 60C is formed in the sealed space 131.

[0080] A gas supply space 70C is defined within container body 10C. In the embodiment of the present disclosure, open space 132 forms gas supply space 70C. Gas generated from ocular irritant 90 arranged in irritant arrangement portion 60C of sealed space 131 is supplied to gas supply space 70C through vent 220.

[0081] To collect tears from the subject's eye 1000 using the device 100C, the container body 10C is attached with the rim 15 in close contact with the face around the periphery of the eye 1000. The subject tilts their head so that the outer corner 1002 of the eye 1000 against which the container body 10C is pressed is positioned downward relative to the inner corner 1001.

[0082] The gas generated from the ocular stimulant 90 is supplied to the gas supply space 70C, thereby stimulating the subject's eye 1000. As a result, tears secreted from the eye 1000 flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage section 80C of the container body 10C. In this way, the tears are collected by the container body 10C. The partition wall 20C inside the container body 10C prevents the collected tears from flowing toward the stimulant placement section 60C where the ocular stimulant 90 is placed.

[0083] The device 100C described above makes it possible to efficiently collect tears while minimizing the burden on the subject.

[0084] 7 and 8 show a device 100D according to an embodiment. In the following description, components common to the device 100A shown in FIGS. 1 and 2 are denoted by the same reference numerals as in FIGS. 1 and 2, and descriptions thereof will be omitted.

[0085] A device 100D shown in FIGS. 7 and 8 includes a container body 10D and a partition wall 20D.

[0086] The container body 10D has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15.

[0087] The partition wall 20D divides the interior of the container body 10D into multiple spaces. The partition wall 20D is formed on the bottom 11. The partition wall 20D is cylindrical. The partition wall 20D extends from the bottom 11 to one side Da1 in the first direction Da. The height of the partition wall 20D from the bottom 11 is lower than the edge 15 of the container body 10D. The partition wall 20D has a circular cross-sectional shape when viewed from the first direction Da. The cross-sectional shape of the partition wall 20D may be elliptical, polygonal, or the like. The partition wall 20D is disposed in the center of the bottom 11 when viewed from the first direction Da. The partition wall 20D divides the interior of the container body 10D into an inner compartment 141 and an outer compartment 142. The inner compartment 141 is formed radially inward of the partition wall 20D. The outer compartment 142 is formed radially outward of the partition wall 20D.

[0088] A gas supply space 70D and a tear fluid storage section 80D are arranged within container body 10D. Partition wall 20D divides the interior of container body 10D into a stimulant disposing section 60D and a tear fluid storage section 80D. In the present disclosure, inner compartment 141 forms stimulant disposing section 60D. Outer compartment 142 forms tear fluid storage section 80D.

[0089] Gas supply space 70D is defined by container body 10D. Gas generated from ocular stimulant 90 placed in stimulant placement portion 60D can fill (fill) the entire interior of container body 10D. In an embodiment of the present disclosure, gas supply space 70D is the entire interior of container body 10D.

[0090] To collect tears from the subject's eye 1000 using the device 100D, the container body 10D is attached with the rim 15 in close contact with the face around the periphery of the eye 1000.

[0091] The gas in gas supply space 70D generated by ocular stimulant 90 stimulates the subject's eye 1000. This causes tears to be secreted from eye 1000. The secreted tears flow out of eye 1000. The flowing tears flow into tear storage section 80D of container body 10D. In this way, tears are collected by container body 10D. Partition wall 20D within container body 10D prevents the collected tears from flowing toward stimulant placement section 60D where ocular stimulant 90 is placed.

[0092] The device 100D described above makes it possible to efficiently collect tears while minimizing the burden on the subject.

[0093] 9 and 10 show a device 100E according to an embodiment. In the following description, components common to the device 100A shown in FIGS. 1 and 2 are denoted by the same reference numerals as in FIGS. 1 and 2, and descriptions thereof will be omitted.

[0094] A device 100E shown in FIGS. 9 and 10 includes a container body 10E and a partition wall 20E.

[0095] The container body 10E has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15.

[0096] The partition wall 20E divides the interior of the container body 10E into multiple spaces. The partition wall 20E is disposed at a central position in the first direction Da on the peripheral wall 12. The partition wall 20E is disposed away from the bottom 11 on one side Da1 in the first direction Da. The partition wall 20E is disposed in a planar direction intersecting the first direction Da. The partition wall 20E is disposed on the first side Db1 in the second direction Db, with a communicating portion 230 spaced apart from the peripheral wall inner surface 114 on the first end 101 side.

[0097] The partition wall 20E is inclined toward the other side Da2 of the first direction Da from the first end 101 side toward the second end 102 side of the container body 10E with respect to a plane direction perpendicular to the first direction Da. The partition wall 20E is formed so as to partially block the internal space of the container body 10E when viewed from the first direction Da.

[0098] The partition wall 20E partially divides the space within the container body 10E into a bottom-side space 151 and an opening-side space 152. The bottom-side space 151 is formed within the container body 10E on the other side Da2 (bottom 11 side) in the first direction Da across the partition wall 20E. The opening-side space 152 is formed on one side Da1 (opening 13 side) in the first direction Da across the partition wall 20E. The bottom-side space 151 and the opening-side space 152 are in communication with each other via a communication portion 230.

[0099] A stimulant-arranging section 60E and a tear fluid containing section 80E are arranged within container body 10E. Partition wall 20E partially divides the interior of container body 10E into stimulant-arranging section 60E and tear fluid containing section 80E. In the present disclosure, bottom-side space 151 forms stimulant-arranging section 60E. Opening-side space 152 forms tear fluid containing section 80E.

[0100] Gas supply space 70E is defined by container body 10E. Gas generated from ocular stimulant 90 placed in stimulant placement section 60E flows from bottom-side space 151 through communication section 230 into opening-side space 152. Gas generated from ocular stimulant 90 can fill (permeate) the entire interior of container body 10E. In an embodiment of the present disclosure, gas supply space 70E is the entire interior of container body 10E.

[0101] To collect tears from the subject's eye 1000 using the device 100E, the container body 10E is attached with the rim 15 tightly attached to the face around the periphery of the eye 1000. The subject tilts their head so that the outer corner 1002 of the eye 1000 against which the container body 10E is pressed is downward relative to the inner corner 1001.

[0102] The gas in the gas supply space 70E generated by the ocular stimulant 90 stimulates the subject's eye 1000. This causes tears to be secreted from the eye 1000. The secreted tears flow out of the eye 1000. The flowing tears flow into the tear storage section 80E of the container body 10E. In this way, the tears are collected by the container body 10E. The partition wall 20E in the container body 10E prevents the collected tears from flowing toward the stimulant placement section 60E where the ocular stimulant 90 is placed. The partition wall 20E is inclined toward the other side Da2, from the first end 101 side toward the second end 102 side of the container body 10E, with respect to a plane direction perpendicular to the first direction Da. This prevents tears from flowing toward the communicating section 230.

[0103] The device 100E described above makes it possible to efficiently collect tears while minimizing the burden on the subject.

[0104] Figure 11 shows a device 100F according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and descriptions thereof will be omitted.

[0105] 11 includes a container body 10F. The container body 10F has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15. A stimulant-disposing portion 60F, a gas-supplied space 70F, and a tear-containing portion 80F are arranged within the container body 10F.

[0106] The stimulant-arranging section 60F is disposed on the bottom 11. The stimulant-arranging section 60F may be disposed on the bottom 11 at a position biased toward the first side Db1 in the second direction Db. The stimulant-arranging section 60F may, for example, simply place the eye stimulant 90 on the bottom 11. The stimulant-arranging section 60F may, for example, fix the eye stimulant 90 to the bottom 11 with an adhesive or the like.

[0107] Gas supply space 70F is defined by container body 10F. Gas generated from ocular stimulant 90 placed in stimulant placement portion 60F can fill (permeate) the entire interior of container body 10F. In an embodiment of the present disclosure, gas supply space 70F is the entire interior of container body 10F.

[0108] The tear collection section 80F is formed inside the container body 10F. To collect tears from the subject's eye using the device 100F, the container body 10F is worn with the edge 15 in close contact with the face around the periphery of the eye 1000. The subject tilts their head so that the outer corner 1002 of the eye 1000 against which the container body 10F is pressed is downward relative to the inner corner 1001. The tear collection section 80F is formed in the container body 10F in an area on the second side Db2 in the second direction Db, which is the outer corner 1002 side of the eye.

[0109] The gas generated from eye stimulant 90 is supplied to gas supply space 70F, thereby stimulating eye 1000 of the subject. As a result, tears secreted from eye 1000 flow out of eye 1000 from the lower outer corner 1002 side. The flowing tears flow into tear storage portion 80F of container body 10F. In this way, tears are collected by container body 10F.

[0110] The device 100F described above makes it possible to efficiently collect tears while minimizing the burden on the subject.

[0111] Figure 12 shows a device 100G according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and descriptions thereof will be omitted.

[0112] 12 includes a container body 10G. The container body 10G has a bottom 11G, a peripheral wall 12, an opening 13, and a rim 15.

[0113] The bottom 11G has a bottom intermediate portion 115 between the first end 101 and the second end 102 that is raised in the second direction Db. The bottom 11G is inclined from the bottom intermediate portion 115 toward the first end 101 side Da1 in the second direction Db and toward the second end 102 side Da2 in the second direction Db, respectively, toward the other side Da2 in the first direction Da (the bottom 11 side).

[0114] A stimulant arranging section 60G, a gas supply space 70G, and a tear fluid containing section 80G are arranged within the container body 10G.

[0115] The stimulant-arranging portion 60G is disposed on the bottom portion 11G. The stimulant-arranging portion 60G is disposed on the bottom portion 11G on the first side Db1 in the second direction Db relative to the raised bottom intermediate portion 115.

[0116] Gas supply space 70G is defined by container body 10G. Gas generated from ocular stimulant 90 placed in stimulant placement portion 60G can fill (permeate) the entire interior of container body 10G. In an embodiment of the present disclosure, gas supply space 70G is the entire interior of container body 10G.

[0117] The tear collection section 80G is formed inside the container body 10G. To collect tears from the subject's eye 1000 using the device 100G, the container body 10G is worn with the rim 15 in close contact with the face around the periphery of the eye 1000. The subject tilts their head so that the outer corner 1002 of the eye 1000 against which the container body 10G is pressed is downward relative to the inner corner 1001. The tear collection section 80G is located on the second side Db2 in the container body 10G in the second direction Db relative to the raised bottom intermediate portion 115.

[0118] The gas generated from the eye stimulant 90 is supplied to the gas supply space 70G, thereby stimulating the eye 1000 of the subject. As a result, tears secreted from the eye 1000 flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage portion 80G of the container body 10G. In this way, the tears are collected by the container body 10G. With the device 100G described above, it is possible to efficiently collect tears while minimizing the burden on the subject.

[0119] Figure 13 shows a device 100H according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and description thereof will be omitted. 13 includes a container body 10H. The container body 10H has a bottom 11H, a peripheral wall 12, an opening 13, and a rim 15. A stimulant-disposing portion 60H, a gas-supplied space 70H, and a tear-containing portion 80H are arranged within the container body 10H.

[0120] The bottom 11H is detachable from the peripheral wall 12. The bottom 11H may be configured to be openable and closable relative to the peripheral wall 12. The stimulant placement section 60H is disposed on the bottom 11H. The stimulant placement section 60H may, for example, simply place the ocular stimulant 90 on the bottom 11H. The stimulant placement section 60H may, for example, fix the ocular stimulant 90 to the bottom 11H with an adhesive or the like.

[0121] Gas supply space 70H is defined by container body 10H. Gas generated from ocular stimulant 90 placed in stimulant placement portion 60H can fill (permeate) the entire interior of container body 10H. In an embodiment of the present disclosure, gas supply space 70H is the entire interior of container body 10H.

[0122] The tear collection section 80H is formed inside the container body 10H. To collect tears from the subject's eye 1000 using the device 100H, the container body 10H is worn with the edge 15 in close contact with the face around the periphery of the eye 1000. The subject tilts their head so that the outer corner 1002 of the eye 1000 against which the container body 10H is pressed is downward relative to the inner corner 1001. The tear collection section 80H is formed in the container body 10H in an area on the second side Db2 in the second direction Db, which is the outer corner 1002 side of the eye.

[0123] To collect tears from the subject's eye 1000 using device 100H, first, container body 10H is attached with rim 15 tightly attached to the face around the periphery of eye 1000. At this time, bottom 11H may be detached from peripheral wall 12. After the subject wears device 100H, bottom 11H with ocular stimulant 90 placed thereon is attached to peripheral wall 12. The ocular stimulant 90 is placed in a state where it can generate gas by dripping substrate solution or water onto it. The gas generated from the eye stimulant 90 is supplied to the gas supply space 70H, thereby stimulating the eye 1000 of the subject. As a result, tears secreted from the eye 1000 flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage section 80H of the container body 10H. In this way, the tears are collected by the container body 10H. With the device 100H described above, tears are collected while minimizing the burden on the subject. This can be done efficiently.

[0124] Figure 14 shows a device 100I according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and descriptions thereof will be omitted. 14 includes a container body 10I. The container body 10I has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15. A stimulant-disposing portion 60I, a gas-supplied space 70I, and a tear-containing portion 80I are arranged within the container body 10I.

[0125] The stimulant arranging section 60I is disposed on the inner circumferential surface of the peripheral wall 12. The stimulant arranging section 60I may be disposed on the inner circumferential surface of the peripheral wall 12 at a position biased towards the first side Db1 in the second direction Db. The stimulant arranging section 60I is disposed on the peripheral wall inner circumferential surface 114 on the first end 101 side of the peripheral wall 12. The stimulant arranging section 60I may, for example, fix the ocular stimulant 90 to the peripheral wall inner circumferential surface 114 with an adhesive or the like.

[0126] Gas supply space 70I is defined by container body 10I. The gas generated from ocular stimulant 90 placed in stimulant placement portion 60I can fill (permeate) the entire interior of container body 10I. In an embodiment of the present disclosure, gas supply space 70I is the entire interior of container body 10I.

[0127] The tear collection section 80I is formed inside the container body 10I. To collect tear from the subject's eye 1000 using the device 100I, the container body 10I is worn with the edge 15 in close contact with the face around the periphery of the eye 1000. The subject tilts their head so that the outer corner 1002 of the eye 1000 against which the container body 10I is pressed is downward relative to the inner corner 1001. The tear collection section 80I is formed in the container body 10I in an area on the second side Db2 in the second direction Db, which is the outer corner 1002 side of the eye.

[0128] The gas generated from the eye stimulant 90 is supplied to the gas supply space 70I, thereby stimulating the eye 1000 of the subject. As a result, tears secreted from the eye 1000 flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage portion 80I of the container body 10I. In this way, the tears are collected by the container body 10I. With the device 100I described above, it is possible to efficiently collect tears while minimizing the burden on the subject.

[0129] Figure 15 shows a device 100J according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and description thereof will be omitted. 15 includes a container body 10J. The container body 10J has a bottom 11J, a peripheral wall 12, an opening 13, and a rim 15.

[0130] The bottom 11J has a base 117. The base 117 protrudes from the periphery of the bottom 11J toward one side Da1 in the first direction Da. The base 117 is formed in a circular shape when viewed from the first direction Da. The base 117 is formed so that its outer diameter gradually decreases from the bottom 11J toward the one side Da1 in the first direction Da. The base 117 is formed in a substantially truncated cone shape. An annular recess 127 having a circular ring shape when viewed from the first direction Da is formed on the bottom 11J radially outward of the base 117.

[0131] A stimulant-disposing portion 60J, a gas-supplied space 70J, and a tear-containing portion 80J are arranged within the container body 10J. The stimulant placement portion 60J is disposed on the base portion 117. The gas supply space 70J is defined by the container body 10J. The gas generated from the ocular stimulant 90 disposed in the stimulant placement portion 60J can fill (permeate) the entire interior of the container body 10J. In an embodiment of the present disclosure, the gas supply space 70J is the entire interior of the container body 10J. The tear fluid storage portion 80J is formed inside the container body 10J. The tear fluid storage portion 80J is formed in an annular recess 127 formed in the bottom portion 11J.

[0132] The gas generated from the eye stimulant 90 is supplied to the gas supply space 70J, thereby stimulating the eye 1000 of the subject. As a result, tears secreted from the eye 1000 flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage portion 80J of the container body 10J. In this way, the tears are collected by the container body 10J. With the device 100J described above, it is possible to efficiently collect tears while minimizing the burden on the subject.

[0133] Figure 16 shows a device 100K according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and description thereof will be omitted. The device 100K shown in FIG. 16 includes a container body 10K.

[0134] Container body 10K has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15. A stimulant disposing section 60K, a gas supply space 70K, and a tear fluid containing section 80K are arranged within container body 10K.

[0135] The stimulant placement unit 60K includes a holder main body 61 and a connecting member 62. The holder main body 61 holds the ocular stimulant 90. The holder main body 61 may be formed, for example, in a frame shape corresponding to the outer shape of the ocular stimulant 90 so as to hold the outer periphery of the ocular stimulant 90. The holder main body 61 may have any other configuration as long as it can hold the ocular stimulant 90. One end of the connecting member 62 is connected to the holder main body 61. The other end of the connecting member 62 is connected to the container body 10K. The connecting members 62 are provided on both sides of the holder main body 61, sandwiching it between them. The ocular stimulant 90 held in the holder main body 61 is held by multiple connecting members 62. In an embodiment of the present disclosure, the connecting member 62 is provided as, for example, two connecting members. The connecting member 62 may include three or more connecting members. The holder main body 61 and the eye stimulant 90 supported by the connecting member 62 may be disposed away from the bottom 11 on one side Da1 in the first direction Da. The holder main body 61 and the eye stimulant 90 supported by the connecting member 62 may be disposed in contact with the bottom 11. When the connecting member 62 is floating in the internal space of the container body 10K, for example, the volatilization efficiency of the lachrymatory component is increased.

[0136] The gas supply space 70K is defined by the container body 10K. The gas generated from the ocular stimulant 90 placed in the stimulant placement portion 60K can fill (permeate) the entire interior of the container body 10K. In an embodiment of the present disclosure, the gas supply space 70K is the entire interior of the container body 10K.

[0137] The tear storage section 80K is formed inside the container body 10K. Gas generated from the eye stimulant 90 is supplied to the gas supply space 70K, stimulating the subject's eye 1000. As a result, tears secreted from the eye 1000 flow into the tear storage section 80K of the container body 10K. If the holder body 61 supported by the connecting member 62 and the eye stimulant 90 are positioned away from the bottom 11 on one side Da1 in the first direction Da, contact of the eye stimulant 90 with tears is prevented. With the device 100K described above, tears can be collected efficiently while minimizing the burden on the subject.

[0138] Figure 17 shows a device 100L according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and description thereof will be omitted.

[0139] The device 100L shown in FIG. 17 includes a container body 10L and a detachable member 300. The device 100L shown in FIG.

[0140] The container body 10L has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15. The detachable member 300 is configured to be detachable from the opening 13. The detachable member 300 is configured to close the opening 13 when attached to the opening 13.

[0141] The stimulant arranging portion 60L is arranged on the detachable member 300. When the detachable member 300 is attached to the opening 13, the stimulant arranging portion 60L is arranged on the surface of the detachable member 300 on the side facing the inside of the container body 10L. The stimulant placement portion 60L holds the ocular stimulant 90. The stimulant placement portion 60L is attached to the opening 13 of the container body 10L in a state in which a substrate solution or water is dropped onto the ocular stimulant 90 and gas can be generated from the ocular stimulant 90. This supplies gas into the container body 10L.

[0142] The gas supply space 70L is defined by the container body 10L. The gas generated from the ocular stimulant 90 placed in the stimulant placement section 60L can fill (permeate) the entire interior of the container body 10L. In an embodiment of the present disclosure, the gas supply space 70L is the entire interior of the container body 10L. The tear storage section 80L is formed inside the container body 10L.

[0143] When collecting tears, the detachable member 300 is attached to the opening 13 of the container body 10L while gas can be generated from the ocular irritant 90. Once the gas generated from the ocular irritant 90 is supplied to the gas supply space 70L, the detachable member 300 is removed from the opening 13. The user presses the edge 15 of the container body 10L against the face around the periphery of the eye 1000 before the gas diffuses from the gas supply space 70L. This causes the subject's eye 1000 to come into contact with the gas and be stimulated. As a result, tears secreted from the eye 1000 flow into the tear storage portion 80L of the container body 10L. The device 100L described above enables efficient collection of tears while minimizing the burden on the subject.

[0144] Figure 18 shows a device 100M according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and descriptions thereof will be omitted.

[0145] The device 100M shown in FIG. 14 includes a container body 10M and a tear container 400.

[0146] The container body 10M may be any one of the container bodies 10A to 10L described above.

[0147] The tear container 400 is provided integrally with the container body 10M. The tear container 400 collects the tear contained in the tear container portion 80M. The tear container 400 is arranged to extend outward from the opening 13 of the container body 10M. The tear container 400 is formed in a cylindrical shape with a bottom. The tear container 400 has a container opening 401 that opens toward the inner corner of the eye 1001 when the edge 15 of the container body 10M is worn in close contact with the face around the edge of the eye 1000.

[0148] The subject tilts their head so that the outer corner 1002 of the eye 1000 against which the container body 10M is pressed is downward relative to the inner corner 1001. The gas generated from the eye stimulant 90 disposed in the stimulant disposing portion 60M is supplied to the gas supply space 70M, stimulating the subject's eye 1000. As a result, tears secreted from the eye 1000 flow out of the eye 1000 from the outer corner 1002 side, which is the lower side. The flowing tears flow into the tear storage portion 80M of the container body 10M. By tilting the device 100M so that the tear container 400 faces downward, the tears in the tear storage portion 80M of the container body 10M can be collected by the tear container 400. Alternatively, the tears flowing out of the eye 1000 may be collected directly by the tear container 400. In this case, the interior of the tear container 400 forms the tear storage portion 80M.

[0149] Figure 19 shows a device 100N according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and descriptions thereof will be omitted.

[0150] 19 includes a container body 10N and an access opening 500. The container body 10N may be any one of the container bodies 10A to 10L described above.

[0151] The access opening 500 is formed on, for example, the rim 125 of the container body 10N. The access opening 500 is formed to allow access to the interior of the container body 10N from the outside when the container is worn with the rim 15 tightly attached to the face around the periphery of the eye 1000. The access opening 500 is used to collect tears contained in the tear storage compartment 80N of the container body 10N with a collector such as a dropper. The collector can access the tears contained in the tear storage compartment 80N through the access opening 500. The access opening 500 can also be used to introduce gas generated from the eye irritant 90 disposed outside the container body 10N into the container body 10N. In some embodiments, the access opening 500 may be configured to be substantially sealable. The access opening does not have to be completely sealed, but may be sealed to the extent that, for example, the lachrymatory component can sufficiently induce a lachrymatory effect on the eyeball. For example, the access opening may have an openable / closable lid. For example, the access opening may have a resilient lid (including a garbage disposal splash guard) in the shape of a chrysanthemum.

[0152] A device 100X according to an embodiment is shown in Fig. 20. The device 100X shown in Fig. 20 includes a container body 10X and a locking member 600X.

[0153] The container body 10X may be any one of the container bodies 10A to 10N (devices 100A to 100N) described above.

[0154] The fastening device 600X fastens the container body 10X to the head of the user so that the rim 15 fits closely against the face around the periphery of the eye 1000. The fastening device 600X may be, for example, an elastic string (rubber band), a string, a belt, or a tape with a hook-and-loop fastener. For example, one end of two strings 601 is connected to one side of the container body 10X in the second direction Db. One end of the elastic string 602 is connected to the other side of the container body 10X in the second direction Db. The other ends of the two strings 601 are connected to the other end of the elastic string 602. The container body 10X is attached to the head of the subject using such fastening device 600X.

[0155] Fig. 21 shows a device 100Y according to an embodiment. The device 100Y shown in Fig. 21 includes two container bodies 10Y, a connecting member 700Y, and a fastener 600Y.

[0156] The container body 10Y may be any one of the container bodies 10A to 10N (devices 100A to 100N) described above.

[0157] The connecting member 700Y connects the first ends 101 of the two container bodies 10Y together. The first end 101 of the container body 10Y is the inner corner of the eye end of the container body 10Y that faces the inner corner of the eye 1001 when the two container bodies 10Y are worn with their edges 15 in close contact with the face around the periphery of the eye 1000.

[0158] The fastener 600Y fastens the two container bodies 10Y to the user's head so that the edges 15 are in close contact with the facial surface around the periphery of the eye 1000. The fastener 600Y may be, for example, an elastic band, a string, a belt, or a tape with a hook-and-loop fastener. The fastener 600Y connects the second ends 102 of the two container bodies 10Y to each other. The second ends 102 are the ends on the outer corner of the eye 1002 side when the two container bodies 10Y are worn with the edges 15 in close contact with the facial surface around the periphery of the eye 1000. To wear the device 100Y on the user, the fastener 600Y is hung around the back of the user's head with the edges 15 of the two container bodies 10Y in close contact with the facial surface around the periphery of the eye 1000.

[0159] Fig. 22 shows a device 100Z according to an embodiment. The device 100Z shown in Fig. 22 includes two container bodies 10Z, a connecting member 700Z, and a locking member 600Z. The container body 10Z may be any one of the container bodies 10A to 10N (devices 100A to 100N) described above.

[0160] The connecting member 700Z connects the first ends 101 of the two container bodies 10Z together. The first end 101 of the container body 10Z is the inner corner of the eye end of the container body 10Z that faces the inner corner of the eye 1001 when the two container bodies 10Z are worn with their edges 15 in close contact with the face around the periphery of the eye 1000. The connecting member 700Z may be in the shape of a frame having a frame 701 formed to surround the two container bodies 10Z.

[0161] The fasteners 600Z fasten the two container bodies 10Z to the head of the user so that the rims 15 fit closely against the face around the eyes 1000. The fasteners 600Z may be formed like temples on glasses. The fasteners 600Z extend from the second ends 102 of the two container bodies 10Z. When the connecting member 700Z has a frame 701, the fasteners 600Z may be connected to the frame 701. To put the device 100Z on the user, the two container bodies 10Z are placed with the edges 15 of the two container bodies 10Z in close contact with the face around the periphery of the eye 1000, and the fasteners 600Z are hung on the user's ears.

[0162] The present disclosure also provides the following embodiments: A101 The container body has a rim that can be fitted tightly to the face around the periphery of the eye, and defines a gas supply space therein that can be filled with gas generated from the eye irritant. A device that induces tear production. A111 The device of embodiment A101, The device further comprises a stimulant placement section that communicates with the gas supply space and in which the eye stimulant is placed. A112 The device of embodiment A111, The stimulant placement portion is formed in at least a part of the gas supply space. device. A121 A device according to any one of embodiments A101 to A112, comprising The device further comprises a tear storage section inside the container body that collects tears secreted from the eye. A131 A device according to any one of embodiments A101 to A121, comprising The container body is A cup-shaped container having an opening that opens toward one side in the first direction, The edge is formed continuously around the entire periphery of the opening. device. A132 The device of embodiment A131, The container body forms a substantially closed space between the eye and the eye when the edge is in close contact with the face around the eye. device. A133 A device according to embodiment A131 or A132, comprising The container body is a bottom portion disposed on the other side in the first direction; a peripheral wall rising from the peripheral edge of the bottom portion to one side in the first direction, device. A141 The device of embodiment A133, The device includes a partition wall inside the container body that separates the gas supply portion from the tear fluid storage portion. A142 The device of embodiment A141, The container body has a first end located on the outer corner of the eye and a second end located on the inner corner of the eye when the container body is worn with the edge of the container body in close contact with the face in the peripheral area of ​​the eye, the partition wall is disposed between the first end and the second end and partitions the interior of the container body into a first compartment on the first end side and a second compartment on the second end side. device. A143 The device of embodiment A142, comprising: The first compartment forms the tear fluid storage section, and the second compartment forms the gas supply space. device. A144 The device of embodiment A141, The container body has an upper end located on the upper eyelid side and a lower end located on the lower eyelid side when the container body is worn with the edge of the container body in close contact with the face around the eye, The partition wall is disposed between the upper end and the lower end, and partitions the interior of the container body into an upper compartment on the upper end side and a lower compartment on the lower end side. device. A145 The device of embodiment A141, the entire circumference of the outer peripheral end of the partition wall is joined to the inner peripheral surface of the container body, forming an enclosed space between the partition wall and the inner peripheral surface of the container body; The sealed space forms the stimulant placement portion, The partition wall has a vent hole communicating with both surfaces thereof. device. A146 The device of embodiment A141, The partition wall is formed in a cylindrical shape rising from the bottom to one side in the first direction, The stimulant placement portion is arranged inside the cylindrical partition wall, device. A147 The device of embodiment A141, the partition wall is disposed at a middle position of the peripheral wall in the first direction and in a plane direction intersecting the first direction, and partially partitions the internal space of the container body; the stimulant placement portion is disposed on the bottom side in the first direction relative to the partition wall; the tear fluid storage portion is formed on the partition wall on the opposite side to the bottom portion in the first direction. device. A148 The device of embodiment A147, comprising: the partition wall is formed to have a communication portion that communicates the internal space of the container body between the bottom side and the opposite side in the first direction, The communication part is arranged on the inner corner side of the eye when the edge of the container body is attached in close contact with the face in the peripheral area of ​​the eye. device. A149 The device of embodiment A148, comprising: The partition wall is inclined toward the bottom in the first direction from the communication portion toward the peripheral wall. device. A151 A device according to any one of embodiments A133 to A149, comprising The stimulant placement portion is formed on the bottom of the container body. device. A152 The device of embodiment A151, The container body has a first end located on the outer corner of the eye and a second end located on the inner corner of the eye when the container body is worn with the edge of the container body in close contact with the face in the peripheral area of ​​the eye, the bottom portion is inclined from a bottom intermediate portion between the first end and the second end toward the other side in the first direction toward the first end side and the second end side, device. A153 The device of embodiment A152, The stimulant placement portion is formed on the bottom portion toward the second end side relative to the bottom portion intermediate portion. device. A154 The device of embodiment A151, the bottom portion includes a platform portion that rises from a peripheral edge of the bottom portion toward the inside of the bottom portion on one side in the first direction, The stimulant placement portion is formed on the base portion. device. A155 The device of embodiment A151, The bottom portion is detachable from the peripheral wall, The stimulant placement portion is disposed on the bottom portion. device. A156 A device according to any one of embodiments A133 to A148, comprising The stimulant placement portion is formed on the inner circumferential surface of the peripheral wall, device. A157 A device according to any one of embodiments A133 to A148, comprising The stimulant placement unit is A holding portion main body that holds the eye stimulant; a connecting member having one end connected to the holder body and the other end connected to the container body; Equipped with device. A158 A device according to any one of embodiments A133 to A148, comprising a detachable member that is detachable from the opening of the container body, the stimulant placement portion is placed on a surface of the detachable member facing the inside of the container body when the detachable member is attached to the opening. device. A161 A device according to any one of embodiments A101 to A158, comprising The device further comprises a tear fluid container that is integral with the container body and that collects the tear fluid contained in the tear fluid storage section. A162 The device of embodiment A161, The tear fluid container is formed in a cylindrical shape with a bottom extending outward from the opening of the container body. device. A163 The device of embodiment A162, The tear container is positioned on the outer corner of the eye relative to the container body in a state where the edge is in close contact with the face around the eye, The tear container has a container opening that opens to the inner corner of the eye. device. A171 A device according to any one of embodiments A101 to A163, comprising The container body has an access opening through which the inside of the container body can be accessed from the outside when the container body is worn with the edge in close contact with the face around the eye. device. A172 A device according to any one of embodiments A101 to A171, comprising At least a part or all of the container body is formed of a transparent material that allows the inside of the container body to be optically confirmed from the outside. device. A181 A device according to any one of embodiments A101 to A172, comprising The device further comprises a fibrous tissue that carries the ocular irritant and is disposed in the irritant placement portion. A182 A device according to any one of embodiments A101 to A172, comprising The eye irritant is in a liquid form and sealed in a bag. device. A191 A device according to any one of embodiments A101 to A182, comprising The ocular irritant comprises benzyl bromide. device. A192 A device according to any one of embodiments A101 to A182, comprising The ocular irritant comprises syn-propanethial-S-oxide. device. A193 A device according to any one of embodiments A101 to A192, comprising The ocular irritant comprises at least a portion of an enzyme and a substrate that react to generate the gas. device. A194 The device of embodiment A193, The enzyme is placed in the stimulant placement portion in a dry state, The substrate is configured to be added to the enzyme in solution. device. A195 The device of embodiment A194, the enzymes are allinase and lachrymal factor synthase (LFS), The substrate is PRENCSO. device. A201 A device according to any one of embodiments A101 to A195, comprising: Two of the container bodies; a connecting member that connects the inner corner end portions of the two container bodies that are located on the inner corner side of the eyes when the two container bodies are attached with the edges in close contact with the face in the peripheral area of ​​the eyes; 1. A device comprising: A211 A device according to any one of embodiments A101 to A201, comprising: The device further comprises a fastener that can fasten the container body to the subject's head so that the rim fits snugly against the face in the periphery of the eye. A211b The device of embodiment A201, The device further comprises a fastening device that is provided at each of the two container bodies at the end on the outer corner of the eye that faces the outer corner of the eye when the two container bodies are worn with the edges in close contact with the face around the eye, and that can fasten the container body to the subject's head.

[0163] While preferred embodiments of the present invention have been shown and described herein, it will be apparent to those skilled in the art that such embodiments are provided by way of example only. The present invention is not intended to be limited by the specific examples provided herein. While the present invention has been described with reference to the above specification, the descriptions and illustrations of the embodiments herein are not intended to be construed in a limiting sense. Numerous variations, changes, and substitutions will occur to those skilled in the art without departing from the invention. Furthermore, it should be understood that all aspects of the invention are not limited to the specific depictions, configurations, or relative proportions set forth herein, which depend upon a variety of conditions and variables. It should be understood that various alternatives to the embodiments of the invention described herein may be used in practicing the invention. It is therefore contemplated that the present invention shall encompass all such alternatives, modifications, variations, or equivalents. It is intended that the following claims define the scope of the invention, and that methods and structures within the scope of these claims and their equivalents be covered thereby. [Explanation of symbols]

[0164] 10A~10N, 10X~10Z Container body 11, 11G, 11H, 11J bottom 12 Surrounding wall 13 Aperture 15. Edge 20A~20E Partition wall 21 Outer edge 60A~60L Stimulant placement section 60X~60Z locking tool 61 Holding part body 62 Connecting member 70A~70M Gas supply space 80A~80N Tear fluid storage section 90 Eye irritants 91 Fibrous Tissue 100A~100N, 100X~100Z devices 101 First end 102 Second end 103 Upper edge 104 Lower edge 111 First Section 112 Second Section 115 Bottom middle part 117 Daibu 121 Upper Section 122 Lower Section 125 Periphery 131 Closed space 220 Ventilation 230 Communication part 300 Detachable member 320 Ventilation 400 tear container 401 Container opening 500 Access Opening 600X~600Z Locking tool 700Y, 700Z connector 1000 eyes 1001 inner corner of the eye 1002 outer corner of the eye 1003 Upper eyelid 1004 Lower eyelid Da First Direction Da1 one side Da2 other side Db second direction Dc third direction

Claims

1. a cup-shaped container body that is fitted to the face around the eye and defines a gas supply space therein that can be filled with gas generated from the eye irritant; The container body is A cup-shaped container having an opening that opens toward one side in the first direction, The edge is formed continuously around the entire periphery of the opening, The container body is a bottom portion disposed on the other side in the first direction; a peripheral wall rising from a peripheral edge of the bottom portion to one side in the first direction, The bottom portion is detachable from the peripheral wall, The stimulant placement portion is disposed on the bottom portion. A device that induces tear production.

2. The container body further includes a tear collection section for collecting tears secreted from the eye. The device of claim 1 .

3. The container body forms a substantially closed space between the eye and the eye when the edge is in close contact with the face around the eye. The device of claim 1 .

4. a partition wall that separates the gas supply space from the tear fluid storage section is provided inside the container body; The device of claim 1 .

5. The container body has a first end located on the outer corner of the eye and a second end located on the inner corner of the eye when the container body is worn with the edge of the container body in close contact with the face in the peripheral area of ​​the eye, the partition wall is disposed between the first end and the second end and partitions the inside of the container body into a first compartment on the first end side and a second compartment on the second end side; The device of claim 4.

6. The first compartment forms the tear fluid storage section, and the second compartment forms the gas supply space. The device of claim 5.

7. The container body has an upper end located on the upper eyelid side and a lower end located on the lower eyelid side when the container body is worn with the edge of the container body in close contact with the face around the eye, The partition wall is disposed between the upper end and the lower end and partitions the inside of the container body into an upper compartment on the upper end side and a lower compartment on the lower end side. The device of claim 4.

8. the entire circumference of the outer peripheral end of the partition wall is joined to the inner peripheral surface of the container body, forming an enclosed space between the partition wall and the inner peripheral surface of the container body; The sealed space forms the stimulant placement portion, The partition wall has a vent hole communicating with both surfaces thereof. The device of claim 4.

9. The partition wall is formed in a cylindrical shape rising from the bottom to one side in the first direction, The stimulant placement portion is arranged inside the cylindrical partition wall, The device of claim 4.

10. the partition wall is disposed at a middle position of the peripheral wall in the first direction and in a plane direction intersecting the first direction, and partially partitions the internal space of the container body; the stimulant placement portion is disposed on the bottom side in the first direction relative to the partition wall; the tear fluid storage portion is formed on the partition wall on the opposite side to the bottom portion in the first direction. The device of claim 4.

11. the partition wall is formed to have a communication portion that communicates the internal space of the container body between the bottom side and the opposite side in the first direction, The communication part is arranged on the inner corner side of the eye when the edge of the container body is attached in close contact with the face in the peripheral area of ​​the eye. The device of claim 10.

12. The partition wall is inclined toward the bottom in the first direction from the communication portion toward the peripheral wall. The device of claim 11.

13. The container body has a first end located on the outer corner of the eye and a second end located on the inner corner of the eye when the container body is worn with the edge of the container body in close contact with the face in the peripheral area of ​​the eye, the bottom portion is inclined from a bottom portion intermediate portion between the first end and the second end toward the first end side and the second end side toward the other side in the first direction, The device of claim 1 .

14. The stimulant placement portion is formed on the bottom portion toward the second end side relative to the bottom portion intermediate portion. The device of claim 13.

15. The stimulant placement unit is A holding portion main body that holds the eye stimulant; a connecting member having one end connected to the holder body and the other end connected to the container body; Equipped with A device according to any one of claims 1 to 11.

16. a detachable member that is detachable from the opening of the container body, the stimulant placement portion is placed on a surface of the detachable member facing the inside of the container body when the detachable member is attached to the opening. A device according to any one of claims 1 to 11.

17. The device further includes a tear fluid container that is integral with the container body and that collects the tear fluid contained in the tear fluid container.

17. A device according to any one of claims 1 to 16.

18. the tear container is disposed on the outer corner of the eye relative to the container body in a state where the edge is in close contact with the face in the peripheral area of ​​the eye, The tear container has a container opening that opens toward the inner corner of the eye.

18. The device of claim 17.

19. The container body has an access opening through which the inside of the container body can be accessed from the outside when the container body is worn with the edge in close contact with the face around the eye.

17. A device according to any one of claims 1 to 16.

20. At least a part or all of the container body is formed of a transparent material that allows the inside of the container body to be optically confirmed from the outside.

20. A device according to any one of claims 1 to 19.

21. Further comprising a fibrous tissue that carries the eye irritant and is placed in the irritant placement portion, 21. A device according to any one of claims 1 to 20.

22. The eye irritant is in a liquid form and is sealed in a bag.

21. A device according to any one of claims 1 to 20.

23. The ocular irritant comprises benzyl bromide.

23. A device according to any one of claims 1 to 22.

24. The ocular irritant comprises syn-propanethial-S-oxide.

24. A device according to any one of claims 1 to 23.

25. The ocular irritant comprises at least a portion of an enzyme and a substrate that react to generate the gas.

25. A device according to any one of claims 1 to 24.

26. The enzyme is placed in the stimulant placement portion in a dry state, The substrate is configured to be added to the enzyme in solution.

26. The device of claim 25.

27. The enzymes are allinase and lachrymal factor synthase (LFS), The substrate is PRENCS0.

27. The device of claim 26.

28. Two of the container bodies; and a connecting member that connects the inner corner side end portions of the two container bodies that are located on the inner corner side of the eyes when the two container bodies are attached with the edges in close contact with the face in the peripheral area of ​​the eyes.

28. A device according to any one of claims 1 to 27.

29. The container body further includes a fastener that can fasten the container body to the subject's head so that the edge is in close contact with the face in the peripheral area of ​​the eye.

29. A device according to any one of claims 1 to 28.

30. Each of the two container bodies further includes a fastener that is provided at the outer corner end of the eye when the two container bodies are attached with the edges in close contact with the face around the eye, and that can fasten the container body to the head of the subject.

29. The device of claim 28.

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