Treatment selection support device, treatment selection support method, and program

Abstract

The present invention assists with the selection of a treatment method by displaying the information of a plurality of patients. A treatment-method selection assistance device (10) comprises: a medication history acquisition unit (11) that acquires, as a medication history, the history of administering medication to each patient; a medical condition acquisition unit (12) that acquires the medical condition of each patient; and a display control unit (13) that causes a display device to display a display screen on which the medication histories and medical conditions of the plurality of patients are displayed along a time axis.

Description

[Technical Field]

[0001] The present disclosure relates to a treatment method selection support device, a treatment method selection support method, and a computer-readable medium. [Background technology]

[0002] Patent Document 1 discloses an information system that supports the analysis of side effects of prescription drugs, and Patent Document 2 discloses a medical information display device that displays various medical data on a single screen. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] International Publication No. 2015 / 189958 [Patent Document 2] Japanese Patent Publication No. 2020-038641 Summary of the Invention [Problem to be solved by the invention]

[0004] When deciding on a treatment plan for a patient, it is effective to check not only the treatments that have been selected for that patient so far and their effects, but also the treatments that have been selected for other patients and their effects.

[0005] Therefore, one of the objectives that the embodiments disclosed in this specification aim to achieve is to provide a treatment method selection support device that supports the selection of a treatment method by displaying information on multiple patients. [Means for solving the problem]

[0006] A treatment method selection support device according to a first aspect of the present disclosure includes: a medication history acquisition means for acquiring a history of medication administered to each patient as a medication history; a disease state acquisition means for acquiring the disease state of each patient; a display control means for causing a display device to display a screen on which the medication histories and disease states of a plurality of patients are displayed along a time axis; It is equipped with:

[0007] A method for supporting selection of a treatment method according to a second aspect of the present disclosure includes: The computer A medication history is obtained that records the administration of medication to each patient. Obtain the disease status of each patient; A display screen on which the medication histories and disease states of a plurality of patients are displayed along a time axis is displayed on a display device.

[0008] A non-transitory computer-readable medium according to a third aspect of the present disclosure includes: On the computer, A process of acquiring a history of administering drugs to each patient as a medication history; obtaining the disease status of each patient; A process of displaying on a display device a display screen on which the medication histories and the disease states of a plurality of patients are displayed along a time axis; The program for executing the above is stored. [Effects of the Invention]

[0009] According to the present disclosure, the selection of a treatment method can be supported by displaying information on multiple patients. [Brief explanation of the drawings]

[0010] [Figure 1] 1 is a block diagram showing the configuration of a treatment method selection support device according to a first embodiment. [Figure 2] FIG. 10 is a schematic diagram illustrating an example of a displayed screen. [Figure 3] FIG. 10 is a schematic diagram illustrating an example of a displayed screen. [Figure 4] FIG. 10 is a schematic diagram illustrating an example of a displayed screen. [Figure 5] FIG. 10 is a schematic diagram illustrating an example of a displayed screen. [Figure 6]FIG. 10 is a schematic diagram illustrating an example of a displayed screen. DETAILED DESCRIPTION OF THE INVENTION

[0011] (Embodiment 1) 1 is a schematic diagram showing an example of the configuration of a treatment method selection support device 10 according to the first embodiment. The treatment method selection support device 10 includes a medication history acquisition unit 11, a medical condition acquisition unit 12, and a display control unit 13. The treatment method selection support device 10 is connected to a display device (e.g., a display or a monitor) not shown. The treatment method selection support device 10 may include a display device.

[0012] The medication history acquisition unit 11 acquires a history of medications administered to each patient as a medication history. The medication history includes the names of the medications administered to each patient and the periods during which the medications were administered. The medications may be anticancer drugs.

[0013] The disease condition acquisition unit 12 acquires the state of the disease (also referred to as the disease condition) of each patient. If the disease is cancer, the disease condition may be any of the stage, malignancy, classification, and prognostic factors of the cancer.

[0014] The display control unit 13 causes the display device to display a screen on which the medication history and disease state of multiple patients are displayed along a time axis. The time axis may represent the year, month, and date, or the period since an event described below. The display screen includes the medication history and disease state (e.g., the stage of cancer), so the effectiveness of drug treatment can be understood by looking at the screen. This allows the user (doctor) to select a treatment method appropriate for treating the patient. The selection of a treatment method is not limited to selecting a drug to be administered. Radiation therapy may also be selected as a treatment method.

[0015] The display control unit 13 may further display on the screen events, the dates of which are determined for each patient. In such cases, marks indicating the events are further displayed along the time axis. An event may be, for example, the start or end of drug administration. When displaying the end of drug administration, the display control unit 13 may further display "ineffective discontinuation" or "planned termination" as the reason for termination. In addition, the display control unit 13 may display the determination of the best overall response, the presence or absence of adverse events of Grade 3 or higher, etc. Furthermore, an event may be the performance of medical treatment or diagnosis for each patient, the collection of a sample for each patient, a change in the patient's condition (e.g., stage), or the discovery or registration of a disease for each patient. The sample may be tumor tissue or non-tumor tissue. Furthermore, an event may be the admission or discharge of a patient, or a change in the treatment plan or drug prescription plan.

[0016] The event may also be the holding of an expert panel for each patient. An expert panel is a meeting where multiple specialists discuss appropriate treatment for a patient based on the results of cancer gene panel testing. The treatment selection support device 10 may be used in the expert panel. A mark indicating the expert panel is displayed on the screen, allowing the user to understand that the treatment plan has changed as a result of the expert panel.

[0017] Furthermore, the event may be related to the response level, which indicates the therapeutic effect for each patient. An example of an event related to the response level is evaluating the response level or performing a test to evaluate the response level. The response level for GIST (Gastrointestinal Stromal Tumor) is known as a criterion for evaluating tumor shrinkage. The response level indicates complete response (CR), partial response (PR), progressive disease (PD), or stable disease (SD). CR indicates complete tumor disappearance. PR indicates a reduction in the sum of tumor diameters by 30% or more. SD indicates no change in tumor size. PD indicates an increase in the sum of tumor diameters by 20% or more, and an absolute increase of 5 mm or more, or the appearance of a new lesion. By having the display control unit 13 display the response level on the screen, the user can more accurately grasp the therapeutic effect of the drug.

[0018] The display control unit 13 may have a function to switch between displaying and hiding marks representing each event.

[0019] As described above, the time axis on the displayed screen may represent the period from an event (e.g., the start of drug treatment), which makes it easier to compare treatment effects even when the start times of drug treatments are different.

[0020] The display control unit 13 may switch between a first screen in which the time axis represents the year, month, and date, and a second screen in which the time axis represents the period from an event, according to a user's selection. By displaying the first screen, the date on which the event occurred can be confirmed. Furthermore, by displaying the second screen, treatment effects can be easily compared between patients even if the dates on which the events occurred differ between patients. The display control unit 13 may further have a function to change the event that serves as the basis for the time axis, according to a user's selection.

[0021] The display control unit 13 may further display on the screen a period during which the drug has not been approved. The period during which the drug has not been approved is a period during which the drug has not been approved or a period during which the approval of the drug has been revoked.

[0022] The display control unit 13 may have a function to display statistical information regarding the medication period when displaying the medication history. The display control unit 13 may have a function to display the response rate indicating how many patients have been administered the drug and how many have achieved remission, together with the average and median values ​​of the medication period.

[0023] The display control unit 13 may further have a function to display each patient's date of birth, the date of cancer registration for each patient, the patient's medical history, the patient's family medical history, and genetic mutation information for each patient. A doctor can select a treatment method for each patient by referring to this information. For example, displaying both information about the patient to be diagnosed and information about patients with similar medical histories and genetic mutations on the display device may lead to the selection of an appropriate treatment method.

[0024] The treatment method selection support device 10 includes a processor, a memory, and a storage device (not shown). The storage device stores a computer program that implements the processing of the treatment method selection support method according to this embodiment. The processor then loads the computer program from the storage device into the memory and executes the computer program. This allows the processor to realize the functions of a medication history acquisition unit 11, a medical condition acquisition unit 12, and a display control unit 13.

[0025] Alternatively, the medication history acquisition unit 11, the medical condition acquisition unit 12, and the display control unit 13 may each be realized by dedicated hardware. Furthermore, some or all of the components of each device may be realized by general-purpose or dedicated circuits, processors, etc., or a combination of these. These may be configured by a single chip, or by multiple chips connected via a bus. Some or all of the components of each device may be realized by a combination of the above-mentioned circuits, etc., and programs. Furthermore, a CPU (Central Processing Unit), GPU (Graphics Processing Unit), FPGA (Field-Programmable Gate Array), quantum processor (quantum computer control chip), etc., may be used as the processor.

[0026] Furthermore, when some or all of the components of the treatment method selection support device 10 are realized by multiple information processing devices, circuits, etc., the multiple information processing devices, circuits, etc. may be centrally or decentralized. For example, the information processing devices, circuits, etc. may be realized as a client-server system, a cloud computing system, or the like, connected via a communication network. Furthermore, the functions of the treatment method selection support device 10 may be provided in a SaaS (Software as a Service) format.

[0027] Next, with reference to Figs. 2 to 6, the screens displayed by the treatment selection support device 10 will be specifically described. Fig. 2 is a schematic diagram illustrating an example of a screen displayed by the display control unit 13. The horizontal direction in Fig. 2 represents the time direction, and the time axis represents the period from the start of drug therapy (for example, the total number of days). A line L1 extending vertically indicates the time when drug therapy started. Y represents the unit of the scale of the time axis, and the period from the start of drug therapy is represented by 1Y to 11Y. The scale of the time axis, i.e., the unit of the auxiliary line, is arbitrary and may be one week, one month, or one year. The display control unit 13 may have a function to switch the unit of the auxiliary line.

[0028] In FIG. 2, the medical conditions (also called status) of patients 1, 2, and 3, the medication histories of patients 1, 2, and 3, and marks indicating events are arranged vertically.

[0029] First, the medical conditions of patients 1, 2, and 3 will be described. In Figure 2, the medical conditions of patient 1, patient 2, and patient 3 are arranged vertically. Each rectangular area represents a period during which the stage of cancer progression of a patient is constant. For example, rectangular area 21 represents the period during which the stage of cancer progression of patient 3 is stage I, rectangular area 22 represents the period during which the stage of cancer progression of patient 3 is stage II, and rectangular area 23 represents the period during which the stage of cancer progression of patient 3 is stage III. Note that I, II, and III represent the Roman numerals 1, 2, and 3, respectively.

[0030] Next, the medication histories of patients 1, 2, and 3 will be described. Drugs A to I represent the administered medications. In the medication history of FIG. 3, the histories of the first to sixth drug therapies are arranged vertically. For example, the history of the third drug therapy includes rectangular portions 31, 32, and 33. Rectangular portion 31 represents the period during which drug C was administered to patient 1, rectangular portion 32 represents the period during which drug A was administered to patient 2, and rectangular portion 33 represents the period during which drug E was administered to patient 3.

[0031] Next, the marks indicating events will be described. Each mark is placed at a position corresponding to the date on which the event occurred. Each mark is composed of a rectangular portion and a straight portion extending downward from the rectangular portion. The characters written in the rectangular portion indicate the name of the event, the above-mentioned efficacy level, etc. The straight portion indicates the precise position on the date on which the event occurred. Below, marks 41 to 49 out of the multiple marks will be specifically described.

[0032] Mark 41 indicates that a diagnosis has been made for patient 1. Mark 42 indicates that patient 2's third medication with drug A was discontinued due to ineffectiveness. Mark 43 indicates that patient 3's third medication with drug E resulted in an adverse event.

[0033] Mark 44 indicates that a sample has been collected from patient 1. The sample will be used for cancer gene panel testing. Marks 45 and 46 indicate that expert panels have been convened for patient 1 and patient 3, respectively. An expert panel is also called an EP (Expert Panel).

[0034] Marks 47 and 48 indicate events related to the response level of patient 2. Furthermore, marks 47 and 48 indicate that the response levels were PR (partial response) and CR (complete response), respectively. Mark 49 indicates an event related to the response level of patient 3, indicating that the response level was PD (progression disease).

[0035] Figure 2 shows the treatment stages of multiple patients, starting from the start date of drug therapy. By checking the treatment effects and response rates of patients (e.g., cancer patients), it is possible to select an appropriate treatment plan.

[0036] In the screen shown in Figure 2, the time axis represents the period elapsed since the start of drug therapy, but as mentioned above, the time axis may represent the number of days elapsed since another event. In Figure 3, the time axis represents the period elapsed since the expert panel was held. Note that other aspects are the same as in Figure 2, and explanations of similar parts to Figure 2 will be omitted. The vertical line L2 indicates the date the expert panel was held. -10Y to 2Y represent the period elapsed since the expert panel was held. A minus sign indicates that the event occurred before the expert panel.

[0037] In Figure 3, the starting point is the start date of the expert panel. Therefore, it is possible to visualize how the treatment plan changed before and after the expert panel was started, i.e., after cancer genome information was taken into account. It also visualizes information on whether the patient's condition improved or worsened after a certain drug was prescribed.

[0038] On the screens shown in Figures 2 and 3, the medication history, medical condition, and events of each patient are displayed separately. However, the display control unit 13 may display information for each patient together. Figure 4 shows a case where information for each patient is displayed together. Note that other than that, it is the same as Figure 2, and the description of the same parts as Figure 2 will be omitted.

[0039] In Figure 4, information on patient 1, patient 2, and patient 3 are arranged vertically. Also, the medication history and events for each patient are displayed vertically. In Figure 4, the display of medical conditions is omitted.

[0040] The displayed screen may include a chart showing the flow of an average drug therapy. Compared to Figure 4, Figures 51, 52, 53, and 54 have been added to Figure 5. The rest of the screen is the same as Figure 2, and the description of the same parts as Figure 2 will be omitted.

[0041] Graphs 51, 52, 53, and 54 show statistical information regarding the duration of medication for drugs A, B, C, and D, respectively.

[0042] Graphics 51 to 54 are each composed of a rectangular portion and a straight line portion. For example, graphic 53 is composed of a rectangular portion 531 and straight line portions 532 and 533. Rectangular portion 531 represents the average administration period of drug C. The period from the left end of straight line portion 532 to the right end of straight line portion 533 represents the maximum administration period of drug C.

[0043] Next, referring to Figure 6, we will explain how to display the period during which a drug has not been approved. In the screen shown in Figure 6, the time axis represents the year, month, and date. 2011 to 2015 represent the Gregorian calendar year, and the auxiliary lines represent one month. Figure 6, like Figure 4, omits the display of the medical condition. Below, we will omit the explanation of the same parts as Figure 2.

[0044] In the medication history of Figure 6, patients who received the same medication are displayed together. The medication history of a drug with generic name X, the medication history of a drug with generic name Y, the medication history of a drug with generic name XX, and the medication history of a drug with generic name Z are arranged vertically. The drug with generic name X includes drug A and drug B. The drug with generic name Y includes drug C. The drug with generic name XX includes drugs D to G. The drug with generic name Z includes drug H and drug I. For example, the medication history of drug C includes the medication history of patient 1 and the medication history of patient 3.

[0045] Rectangular portion 61 indicates the period during which drug A was not approved. Mark 62 indicates the approval date of drug A. Similarly, the period during which drug H was not approved and the approval date of drug H are also shown. In Figure 6, adverse events are displayed as events, but reasons for invalidation may also be displayed.

[0046] Finally, the effects of embodiment 1 will be described. The treatment method selection support device according to embodiment 1 displays the medication histories and medical conditions of multiple patients on a time axis. By displaying information on multiple patients, the treatment method selection support device 10 can support doctors in selecting a treatment method.

[0047] In the above examples, the program includes instructions (or software code) that, when loaded into a computer, cause the computer to perform one or more functions described in the embodiments. The program may be stored on a non-transitory computer-readable medium or a tangible storage medium. By way of example and not limitation, computer-readable medium or tangible storage medium includes random-access memory (RAM), read-only memory (ROM), flash memory, solid-state drive (SSD) or other memory technology, CD-ROM, digital versatile disc (DVD), Blu-ray disc or other optical disk storage, magnetic cassette, magnetic tape, magnetic disk storage or other magnetic storage device. The program may also be transmitted on a transitory computer-readable medium or communication medium. By way of example and not limitation, transitory computer-readable medium or communication medium includes electrical, optical, acoustic, or other forms of propagated signals.

[0048] The present disclosure is not limited to the above-described embodiments, and may be modified as appropriate without departing from the spirit and scope of the present disclosure. In addition, the present disclosure may be implemented by appropriately combining the respective embodiments.

[0049] Although the present invention has been described above with reference to the embodiments, the present invention is not limited to the above-described embodiments. Various modifications that can be understood by those skilled in the art can be made to the configuration and details of the present invention within the scope of the present invention. [Explanation of symbols]

[0050] 10 Treatment Selection Support Device 11 Medication history acquisition unit 12. Medical Condition Acquisition Department 13 Display control unit 1, 2, 3 patients A, B, C, D, E, F, G, H, I drugs 21, 22, 23, 31, 32, 33, 531, 61 rectangular part 41, 42, 43, 44, 45, 46, 47, 48, 49, 62 marks 51, 52, 53, 54 Shapes 532, 533 Straight section L1, L2 straight line

Claims

1. a medication history acquisition means for acquiring a history of administration of each of a plurality of types of drugs to each patient as a medication history; a disease state acquisition means for acquiring the disease state of each patient; a display control means for causing a display device to display a screen on which the medication histories and disease states of a plurality of patients are displayed along a time axis; Equipped with The display control means Further displaying the event on the screen in accordance with information acquired from a storage unit in which information on the event, the date of which is determined for each patient, is previously stored; The expert panel meeting for each patient is displayed as an event. Treatment selection support device.

2. The display control means switching between a first screen in which the time axis represents the year, month, and day and a second screen in which the time axis represents the period from the event in response to a user selection; The treatment method selection support device according to claim 1 .

3. The display control means further displaying, on the screen, a period during which the drug has not been approved, in accordance with information acquired from the storage unit in which information on the period during which the drug has not been approved is previously stored; The treatment method selection support device according to claim 1 or 2.

4. The disease state is any one of the progression, malignancy, class classification, and prognostic factors of cancer. The treatment method selection support device according to any one of claims 1 to 3.

5. The display control means further displaying at least one of the medical history of each patient, the medical history of each patient's family, and genetic mutation information of each patient on the screen; The treatment method selection support device according to any one of claims 1 to 4.

6. The computer Acquiring a medication history that includes a history of administration of each of a plurality of types of drugs to each patient; obtaining a disease state for each patient; displaying on a display device a screen in which the histories and disease states of a plurality of patients are displayed along a time axis; Including, The displaying includes: Further displaying the event on the screen in accordance with information acquired from a storage unit in which information on the event, the date of which is determined for each patient, is previously stored; The expert panel meeting for each patient is displayed as an event. Methods for supporting treatment selection.

7. On the computer, A process of acquiring a history of administration of each of a plurality of types of drugs to each patient as a medication history; obtaining the disease status of each patient; a process of displaying on a display device a screen in which the histories and disease states of a plurality of patients are displayed along a time axis; Execute The display process includes: Further displaying the event on the screen in accordance with information acquired from a storage unit in which information on the event, the date of which is determined for each patient, is previously stored; The expert panel meeting for each patient is displayed as an event. program.

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