Spectral domain optical nonlinear tomography

JP7789433B2Active Publication Date: 2025-12-22PHILOPHOS INC
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Patent Information

Application Number
JP2024531318
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2021-11-25
Filing Date
2022-03-22
Publication Date
2025-12-22
Estimated Expiration
2042-03-22

AI Technical Summary

Technical Problem

Conventional optical coherence tomography (OCT) devices suffer from limited image contrast ratios due to the dominance of the DC component in the detected signal, leading to reduced image quality and limited observable depth within biological tissues.

Method used

The proposed optical tomography device employs a detection unit that generates nonlinear light by mixing sample and reference light in a nonlinear crystal, canceling out phase components using symmetrically arranged diffraction gratings, and performs Fourier transforms optically, eliminating the need for separate signal processing on a computer.

Benefits of technology

This approach enhances image contrast ratios, enables faster processing speeds, and allows for deeper tissue observation compared to conventional OCT devices, while potentially reducing costs by using conventional Si image sensors instead of expensive InGaAs sensors.

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Abstract

The optical tomography apparatus according to the present invention includes a sample optical path system that injects light incident from a light source into a sample corresponding to a biological tissue, a reference optical path system that collects the light incident from the light source, and a detection unit that detects a tomographic image of the sample by causing interference between the sample light transmitted from the sample optical path system and reflected from the sample, and the reference light transmitted from the reference optical path system. The detection unit includes a nonlinear crystal that receives the sample light and the reference light and generates nonlinear light having a wavelength different from that of the sample light and the reference light, and an image sensor that detects a depth direction signal from the nonlinear light.
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