Cell quality control method and cell manufacturing method

Abstract

An object of the present invention is to provide a method for quality control of cells that enables selection of cells having medicinal properties, and a method for producing cells that utilizes the quality control method. [Solution] According to the present invention, a method for quality control of cells for therapy or drug discovery is provided, which includes managing the behavior of one or more specific protein molecules that are essential for the cells to express a therapeutic effect, and managing the expression behavior of a group of related genes that are characteristic of the cells.

Description

[Technical Field]

[0001] The present invention relates to a quality control method for cells for therapy or drug discovery, which comprises controlling the behavior of specific protein molecules that are essential for the manifestation of therapeutic effects and controlling the expression behavior of related genes characteristic of cells. The present invention also relates to a method for producing cells using the above quality control method. [Background technology]

[0002] In recent years, advances in regenerative medicine and cell therapy technologies have led to the active development of various cell therapies and research cell products using autologous, allogeneic, or xenogeneic cells. For example, mesenchymal stem cells (MSCs) are expected to be a useful cell source for cell therapy. Mesenchymal stem cells can be collected from various body tissues, and it has been reported that they can be isolated from bone marrow tissue (Non-Patent Document 1), adipose tissue (Non-Patent Document 2), muscle tissue (Non-Patent Document 3), synovial tissue (Non-Patent Document 4), or periosteal tissue (Non-Patent Document 5). In particular, synovial-derived mesenchymal stem cells have been reported to have higher proliferation and chondrogenic potential than mesenchymal stem cells derived from various mesenchymal tissues, such as bone marrow (Non-Patent Document 6).

[0003] Furthermore, Patent Documents 1 and 2 disclose methods for treating articular cartilage damage and meniscus damage using synovium-derived mesenchymal stem cells.

[0004] However, it is known that ensuring the equivalence and identity of each lot in the quality control of cell products is extremely difficult. This is primarily due to the fact that the cells themselves that make up the product are not completely uniform, making it difficult to identify their characteristics. Therefore, in order to control product quality, not only have the quality testing of the final product been carried out, but also the QMS concept applied to medical devices has been adopted, and management of the entire process has been carried out by recording and controlling raw materials, material control, manufacturing process control, and process control tests. However, with advances in science and technology, the importance of identifying and describing the characteristics of the cells themselves, which are the final product, has increased. Cell quality control methods have been reported, such as one that uses the expression of several specific proteins as an indicator (Patent Document 3), but they have not yet been fully satisfactory. [Prior art documents] [Non-patent literature]

[0005] [Non-Patent Document 1] Prockop, DJ, 1997, Science. 276:71-4 [Non-patent document 2] Zuk, PA et al., 2002, Mol Biol Cell. 13:4279-95 [Non-patent document 3] Cao et al., 2003, Nat Cell Biol. 5:640-6 [Non-patent document 4] De Bari, C. et al., 2001, Arthritis Rheum. 44:1928-42 [Non-patent document 5] Fukumoto, T. et al., 2003, Osteoarthritis Cartilage. 11:55-64 [Non-patent document 6] Sakaguchi, et al., 2005, Arthritis Rhum. 52:2521-9 [Patent documents]

[0006] [Patent Document 1] Patent No. 5928961 [Patent Document 2] Patent No. 5656183 [Patent Document 3] Japanese Patent Application Publication No. 2018-117582 Summary of the Invention [Problem to be solved by the invention]

[0007] Conventionally, as described in Patent Document 3, methods for controlling the expression levels of several specific proteins have been disclosed for quality control of cell products. However, these methods are insufficient for identifying and controlling crude substances such as cells, and as a result, it has become clear that the equivalence and homogeneity of cell products cannot be fully controlled. In addition, for cell therapy products, there has been a demand for the identification and control of molecules directly related to the medicinal effects.

[0008] An object of the present invention is to provide a method for quality control of cells, which allows selection of cells having medicinal properties, and a method for producing cells utilizing the above quality control method. [Means for solving the problem]

[0009] As a result of intensive research conducted by the present inventors to solve the above problems, the present inventors have succeeded in selecting cells having a reliable medicinal effect based on the mechanism of action molecules, while separating and managing similar cell populations, by combining the management of specific protein molecules essential for the medicinal effect related to the mechanism of action with the management of the expression behavior pattern of related genes characteristic of the cell population. The present invention was completed based on the above findings.

[0010] That is, according to the present invention, the following inventions are provided. <1> A method for quality control of cells for therapy or drug discovery, comprising: Controlling the behavior of one or more specific protein molecules that are essential for the expression of a therapeutic effect by cells; Managing the expression behavior of related genes characteristic of the cells; and <2> The gene cluster characteristic of the above cells consists of 10 to 2,000 genes. <1> The method described below. <3> The related gene group characteristic of the cells is selected from at least one of immune-related gene group, inflammation-related gene group, angiogenesis-related gene group, nerve regeneration-related gene group, chondrogenesis-related gene group, osteogenesis-related gene group, adipogenesis-related gene group, fibrosis-related gene group, immunogenicity-related gene group, migration-related gene group, adhesion-related gene group, aging-related gene group, mesenchymal stem cell marker-related gene group, surface marker-related gene group, growth factor-related gene group, and chemokine or cytokine-related gene group; <1> or <2> The method described below. <4> In managing the expression behavior of the related gene group characteristic of the cell, when the correlation between the expression pattern of the gene group obtained by measuring the expression state of the related gene group characteristic of the cell and a reference expression pattern is equal to or greater than a certain level, the cell is determined to be usable. <1> from <3> 1. The method according to claim 1 , <5> The case where the correlation is above a certain level is when the correlation coefficient or the coefficient of determination, or the correlation coefficient and the coefficient of determination, are evaluated and the correlation coefficient or the coefficient of determination is above a certain level. <4> The method described below. <6> When evaluating the correlation coefficient or the coefficient of determination, (i) Substitute missing values ​​for which gene expression levels cannot be measured with the lower limit of measurement; (ii) Substitute missing values ​​for which gene expression levels cannot be measured with the lowest measured value, or (iii) Missing values ​​for which gene expression levels cannot be measured are processed using the following formula: read count for each gene + (1 × gene length / average gene length). The correlation coefficient or the coefficient of determination is calculated by performing one of the following: <5> The method described below. <7> The specific protein molecule is a cell surface antigen. <1> from <6> 1. The method according to claim 1 , wherein <8> The specific protein molecule includes one or more of CD29 and CD140b. <1> from <7> 1. The method according to claim 1 , wherein <9> The behavior of the specific protein molecule is the expression level. <1> from <8> 1. The method according to claim 1 , wherein <10> The cell is at least one type of cell selected from the group consisting of somatic stem cells, induced pluripotent stem cells, embryonic stem cells, differentiated cells derived from somatic stem cells, differentiated cells derived from induced pluripotent stem cells, and differentiated cells derived from embryonic stem cells. <1> from <9> 1. The method according to claim 1 , wherein <11> The cells are mesenchymal stem cells. <1> from <10> 1. The method according to claim 1 , wherein <12> The cells are used as a therapeutic agent for treating arthritis. <1> from <11> 1. The method according to claim 1 , wherein <13> The cells are used as a therapeutic agent for meniscus or osteoarthritis. <1> from <12> 1. The method according to claim 1 , wherein <14> The cells are cells for drug discovery. <1> from <11> 1. The method according to claim 1 , wherein <15> Obtaining a cell population containing candidate cells for therapy or drug discovery; and <1> from <14> selecting cells that meet the criteria from the cell population by any one of the methods described above; A method for producing cells for therapy or drug discovery, comprising: [Effects of the Invention]

[0011] According to the present invention, therapeutic efficacy can be ensured by identifying and managing molecules essential for the expression of drug efficacy, which is the most important factor for therapeutic cells. Furthermore, the present invention makes it possible to distinguish between similar cells, thereby enabling quality control that clearly shows the equivalence and homogeneity of cells, which cannot be ensured by the expression of drug efficacy alone. [Brief explanation of the drawings]

[0012] [Figure 1] FIG. 1 shows images of the medial meniscus of both knee joints in a meniscus injury model and a control. [Figure 2] FIG. 2 shows the results of evaluating the efficacy of synovial stem cells in which specific proteins have been inhibited in a meniscus injury model. [Figure 3] FIG. 3 shows the results of evaluating the efficacy of synovial stem cells in a meniscus injury model in which a specific protein was deleted by gene knockout. DETAILED DESCRIPTION OF THE INVENTION

[0013] The present invention will be described in detail below. In this specification, the symbol "to" is used to mean that the numerical values ​​before and after it are included as the lower limit and upper limit.

[0014] The quality control method for cells for therapy or drug discovery according to the present invention is a method comprising managing the behavior of one or more specific protein molecules that are essential for the expression of therapeutic effects by cells, and managing the expression behavior of a group of related genes characteristic of the cells.

[0015] Controlling the behavior of one or more specific protein molecules that are essential for cells to exert a therapeutic effect is quality control (first quality control) based on the identification and management of the mechanism-of-action molecules that are essential for the direct medicinal effect of cells. Managing the expression behavior of related gene groups characteristic of cells is a quality control (second quality control) that identifies gene expression patterns specific to cell populations that contain non-mechanism-of-action molecules that are not necessarily essential for the drug efficacy of the cells, and identifies cells from crude populations based on these patterns.

[0016] A feature of the present invention is the combination of the two quality control methods described above. The first quality control method described above enables the production of cells that exhibit reliable medicinal efficacy, and makes it possible to control the equivalence and homogeneity of efficacy relative to medicinal efficacy. The second quality control method described above makes it possible to control the equivalence and homogeneity of cell populations. In the present invention, the two quality control methods described above enable cell quality control that ensures efficacy, safety, equivalence, and homogeneity, making it possible to provide cell therapy products.

[0017] <cell> The cells that can be used are not particularly limited, but preferably, at least one type of cell selected from the group consisting of somatic stem cells, induced pluripotent stem cells (iPS cells), embryonic stem cells (ES cells), differentiated cells derived from somatic stem cells, differentiated cells derived from induced pluripotent stem cells, and differentiated cells derived from embryonic stem cells can be used.

[0018] Somatic stem cells that can be used include those present in bone marrow, blood, skin (epidermis, dermis, and subcutaneous tissue), fat, hair follicles, brain, nerves, liver, pancreas, kidney, muscle, and other tissues. Preferably, mesenchymal stem cells can be used as somatic stem cells.

[0019] Mesenchymal stem cells are known to exist in bone marrow, synovium, periosteum, adipose tissue, muscle tissue, etc., and are known to have the ability to differentiate into osteoblasts, chondrocytes, adipocytes, and muscle cells. Among the above mesenchymal stem cells, synovium-derived mesenchymal stem cells are known to have high chondrogenic potential.

[0020] Induced pluripotent stem cells (iPS cells) are cells with pluripotency (multiple differentiation potential) and proliferation ability that are produced by reprogramming somatic cells through the introduction of reprogramming factors, etc. The somatic cells used to produce iPS cells are not particularly limited, and may be differentiated somatic cells or undifferentiated stem cells.

[0021] The basic method for generating iPS cells is to use viruses to introduce four transcription factors: Oct3 / 4, Sox2, Klf4, and c-Myc into cells. There have been reports of human iPS cells being generated by introducing four factors: Oct4, Sox2, Lin28, and Nonog. There have also been reports of iPS cells being generated by introducing three factors other than c-Myc, two factors: Oct3 / 4 and Klf4, or Oct3 / 4 alone. Methods for introducing proteins, the expression products of genes, into cells have also been reported. Regarding gene transfer methods, technologies using retroviruses, lentiviruses, adenoviruses, plasmids, transposon vectors, and episomal vectors have been developed.

[0022] Embryonic stem cells (ES cells) can be established, for example, by culturing preimplantation early embryos, inner cell masses that constitute the above-mentioned early embryos, single blastomeres, etc. Early embryos produced by nuclear transfer of somatic cell nuclei may also be used. Parthenogenetic embryos may also be used. Some ES cells are available from repositories or commercially available. For example, human ES cells are available from the National Center for Child Health and Development (e.g., SEES1-7), the Kyoto University Institute for Frontier Medical Sciences (e.g., KhES-1, KhES-2, and KhES-3), WiCell Research Institute, ESI BIO, etc.

[0023] The origin of the cells is not particularly limited, and for example, cells from mammals such as humans, monkeys, mice, rats, guinea pigs, rabbits, cats, dogs, horses, cows, sheep, goats, and pigs can be used.

[0024] When the cells managed in the method of the present invention are used for therapy, the cells may be autologous or allogeneic, but are preferably autologous.

[0025] In the present invention, differentiated cells derived from somatic stem cells, differentiated cells derived from induced pluripotent stem cells, or differentiated cells derived from embryonic stem cells may be used. The conditions and procedures for culture methods for inducing differentiation to obtain differentiated cells are known in the art.

[0026] Culture media for inducing stem cell differentiation include basal media containing components necessary for stem cell survival and proliferation (inorganic salts, carbohydrates, hormones, essential amino acids, non-essential amino acids, vitamins, and fatty acids), such as Dulbeco's Modified Eagle Medium (D-MEM), Minimum Essential Medium (MEM), RPMI 1640, Basal Medium Eagle (BME), Dulbeco's Modified Eagle Medium:Nutrient Mixture F-12 (D-MEM / F-12), Glasgow Minimum Essential Medium (Glasgow MEM), and Hank's Balanced Salt Solution (Hank's Balanced Salt Solution), supplemented with at least one differentiation-inducing factor appropriate for the cell type being differentiated. Examples of adipocyte differentiation-inducing factors include dexamethasone (DEX), 3-isobutyl-1-methylxanthine (IBMX), indomethacin (IDM), insulin (Ins), troglitazone, and biotin. Examples of osteoblast differentiation inducers include dexamethasone (DEX), hydrocortisone, β-glycerophosphate, ascorbic acid, BMP4, and BMP2. Examples of chondrocyte differentiation inducers include TGF-β3, dexamethasone (DEX), and ascorbic acid diphosphate. Furthermore, to increase the cell proliferation rate, the above-mentioned medium may be supplemented with growth factors such as basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF), tumor necrosis factor (TNF), vitamins, interleukins, insulin, transferrin, heparin, heparan sulfate, collagen, bovine serum albumin (BSA), fibronectin, progesterone, selenite, B27 supplement, N2 supplement, ITS supplement, and the like, as well as antibiotics (penicillin, streptomycin, etc.). Each component of the medium should be sterilized by an appropriate method before use. In addition to the above, it is preferable that serum (for example, 10% fetal bovine serum (FBS)) is contained at a content of 1 to 20%.

[0027] Differentiation-inducing media containing differentiation-inducing factors for the target cells are commercially available, and these commercially available media may be used.

[0028] The culture temperature for proliferation and differentiation induction of stem cells varies depending on the origin of the cells, but for example, in the case of human-derived cells, it is preferably 30 to 40° C., more preferably 36 to 38° C. Furthermore, the CO gas concentration is preferably, for example, about 1 to 10%, more preferably about 2 to 5%.

[0029] Confirmation of induction of differentiation into target cells can be performed using known methods depending on the type of differentiated cells. For example, confirmation of induction of differentiation into adipocytes can be performed by staining cells with Oil Red O, measuring the amount of intracellular triglycerides, measuring the expression level of the peroxisome proliferator-activated receptor-γ (PPARγ) gene in cells, etc. Confirmation of induction of differentiation into osteoblasts can be performed by quantifying the amount of calcium deposition in cells, staining cells with alkaline phosphatase, measuring the alkaline phosphatase activity of cells, measuring the expression level of Osterix in cells, etc. Confirmation of induction of differentiation into chondrocytes can be performed by quantifying the amount of glycosaminoglycan in cells, staining cells with Alcian blue, measuring the expression level of collagen type II in cells, etc.

[0030] <Managing the behavior of one or more specific protein molecules that are essential for the expression of therapeutic effects by cells> The first quality control involves controlling the behavior of one or more specific protein molecules that are essential for the cells to exert a therapeutic effect. The specific protein molecule is not particularly limited, but is preferably a cell surface antigen, and more preferably includes one or more of CD29 and CD140b.

[0031] Specifically, controlling the behavior of a specific protein molecule includes controlling the expression level of the specific protein molecule.

[0032] The expression level of a specific protein molecule refers to the expression level of the gene for the specific protein or the expression level of the specific protein. The expression level of a specific protein molecule can be calculated as an absolute value or a relative value (such as a ratio or difference from a comparative control or standard expression level).

[0033] The expression level of a specific protein molecule can be measured by any method known to those skilled in the art and can be carried out according to standard methods. The expression level of a specific protein molecule can be measured by measuring the amount of mRNA, which is a transcription product of a gene. The method for measuring the amount of mRNA is not particularly limited as long as it can measure the desired amount of mRNA, and any known method can be appropriately selected and used. For example, a gene amplification method using an oligonucleotide that hybridizes to a gene encoding a specific protein molecule as a primer, or a hybridization method using an oligo(poly)nucleotide that hybridizes to a gene encoding a specific protein molecule as a probe can be used. Specific examples of such methods include RT-PCR (reverse transcription polymerase chain reaction), real-time RT-PCR, DNA microarray, cell array, Northern blot, dot blot, and RNase protection assay.

[0034] The primers and probes used in the above measurement methods can be labeled, and the amount of mRNA can be measured by examining the signal intensity of the label. Real-time RT-PCR is preferable because it allows RNA to be used directly as a sample and allows gene quantification based on the number of temperature cycles required for amplification by optically measuring the gene amplification process. Furthermore, the expression levels of mRNAs such as housekeeping genes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and beta-actin can be used as controls to standardize the expression levels of genes encoding specific protein molecules. The primers and probes used in the above measurement methods can be appropriately designed and prepared by those skilled in the art based on information about the nucleotide sequence of the gene encoding the specific protein molecule.

[0035] The expression level of a protein can be measured, for example, by immunological methods using antibodies or antibody fragments against a specific protein. Specific examples include flow cytometry, Western blotting, enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA), fluorescent antibody assay, cell array assay, etc. These measurement methods can also be performed using standard protocols or protocols that have been appropriately modified or altered from standard protocols.

[0036] For example, when measuring the expression level of a protein in cells by flow cytometry, the quality of the cells can be evaluated as high if the positive rate of a specific protein is preferably 70% or more, more preferably 80% or more, and even more preferably 90% or more.

[0037] In the present invention, the first quality control can be performed, for example, by comparing the expression level of a specific protein molecule in cells measured by the above-mentioned method with a predetermined reference expression level. The reference expression level may be, for example, the expression level of a specific protein molecule in cells that have already been confirmed to have a certain quality (positive control), or the expression level of cells that have already been confirmed to not have a certain quality (negative control).

[0038] By comparing the expression level of a specific protein molecule in a cell with a reference expression level, if the expression level of the specific protein molecule in the cell is equal to or higher than the expression level of the positive control, the quality of the cell can be evaluated as high, and if the expression level of the specific protein molecule in the cell is equal to or lower than the expression level of the negative control, the quality of the cell can be evaluated as low.

[0039] Alternatively, a cutoff value for the expression level of a specific protein molecule may be set in advance, and the expression level of the specific protein molecule measured for the cell may be compared with the cutoff value. The cutoff value may be set to the expression level of the specific protein molecule that provides the desired therapeutic effect, for example, based on a regression line showing the correlation between the expression amount of the specific protein molecule and the therapeutic effect. For example, if the expression level of the specific protein molecule of a cell is equal to or greater than the cutoff value, the cell can be evaluated as having high quality, and if it is equal to or less than the cutoff value, the cell can be evaluated as having low quality.

[0040] <Managing the expression behavior of related gene groups characteristic of cells> The second quality control involves monitoring the expression behavior of related genes characteristic of the cells. The cell-specific related gene group preferably consists of 10 to 5,000 genes, more preferably 10 to 2,000 genes. The lower limit of the number of genes may be 20 or more, 30 or more, 40 or more, 50 or more, 100 or more, 200 or more, 300 or more, or 500 or more. The upper limit of the number of genes may be 4,000 or less, 3,000 or less, 2,000 or less, or 1,500 or less.

[0041] The gene group characteristic of a cell is not particularly limited and can be appropriately selected depending on the type of cell. For example, when the cell is a mesenchymal stem cell, the gene group can be selected from at least one of immune-related genes, inflammation-related genes, angiogenesis-related genes, nerve regeneration-related genes, chondrogenesis-related genes, osteogenesis-related genes, adipogenesis-related genes, fibrosis-related genes, immunogenicity-related genes, migration-related genes, adhesion-related genes, aging-related genes, mesenchymal stem cell marker-related genes, surface marker-related genes, growth factor-related genes, and chemokine- or cytokine-related genes (e.g., 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 of the above-mentioned gene groups).

[0042] The above-mentioned various gene groups can be collected using, for example, commercially available panels, literature information, microarray data, or publicly known databases (e.g., Ontology database (http: / / www.informatics.jax.org / vocab / gene_ontology / )). Furthermore, frequently appearing genes can be selected from the collected gene groups and used.

[0043] In the second quality control, the usability of a cell can be determined based on the correlation between the expression pattern of the gene group obtained by measuring the expression state of the related gene group characteristic of the cell and a reference expression pattern. Specifically, the cell can be determined to be usable if the correlation between the expression pattern of the gene group obtained by measuring the expression state of the related gene group characteristic of the cell and the reference expression pattern is at least a certain level. For example, the correlation coefficient or coefficient of determination between the expression pattern of the gene group obtained by measuring the expression state of the related gene group characteristic of the cell and the reference expression pattern, or the correlation coefficient and the coefficient of determination, can be evaluated, and the cell can be determined to be usable if the correlation coefficient or the coefficient of determination is at least a certain level.

[0044] The method for measuring the expression state is not particularly limited, but the amount of mRNA can be measured. The method for measuring the amount of mRNA is not particularly limited as long as it can measure the desired amount of mRNA, and any known method can be appropriately selected and used. For example, RNA sequencing (RNA-Seq), RT-PCR, real-time RT-PCR, etc. can be used.

[0045] The coefficient of determination can be calculated by various methods, and is not particularly limited. As an example, a method using the RSQ function adopted in Microsoft Excel (registered trademark) can be used. The RSQ function returns the value of r squared (coefficient of determination) for a regression line using the (x, y) pair of the total gene group, consisting of the expression level y of a certain gene in a first target sample and the expression level x of the same gene in a second target sample, thereby making it possible to obtain the coefficient of determination between two target samples.

[0046] Various methods can be used to calculate the correlation coefficient, and there is no particular limitation. As an example, a method using the CORREL function adopted in Microsoft Excel (registered trademark) can be used. The CORREL function returns the value of the correlation coefficient for the (x, y) pair of the total gene group consisting of the expression level y of a certain gene in a first target sample and the expression level x of the same gene in a second target sample, thereby making it possible to obtain the correlation coefficient between two target samples.

[0047] When evaluating the correlation coefficient or coefficient of determination, (i) Substitute missing values ​​for which gene expression levels cannot be measured with the lower limit of measurement; (ii) Substitute missing values ​​for which gene expression levels cannot be measured with the lowest measured value, or (iii) Missing values ​​for which gene expression levels cannot be measured are processed using the following formula: read count for each gene + (1 × gene length / average gene length). It is preferable to calculate the correlation coefficient or the coefficient of determination by performing either of the above.

[0048] RNA sequencing (RNA-Seq) is a method for quantifying gene expression levels using a sequencer. The analysis process involves (1) performing quality control on the reads output from the sequencer, (2) mapping the reads to a reference sequence, and (3) counting the number of reads mapped to each gene region. The number of reads counted for each gene region can be considered the relative expression level of that gene. In other words, the read count for each gene is a typical output result obtained in gene expression analysis, and is a value tallied for each gene region.

[0049] The threshold value for the coefficient of determination or correlation coefficient can be selected from, for example, 0.70 or more, 0.71 or more, 0.72 or more, 0.73 or more, 0.74 or more, 0.75 or more, 0.76 or more, 0.77 or more, 0.78 or more, 0.79 or more, 0.80 or more, 0.81 or more, 0.82 or more, 0.83 or more, 0.84 or more, 0.85 or more, 0.86 or more, 0.87 or more, 0.88 or more, 0.89 or more, etc. depending on the cell type to be distinguished.

[0050] <Cell production method and cell use for treatment or drug discovery> According to the present invention, after obtaining a cell population containing candidate cells for therapy or drug discovery, cells that meet criteria can be selected from the cell population using the cell quality control method of the present invention, thereby producing cells for therapy or drug discovery.

[0051] Cells whose quality has been confirmed by the present invention can be used for regenerative medicine and basic research (e.g., drug discovery, etc.). For example, cells whose quality has been confirmed by the present invention can be used as transplant materials for the treatment of damaged or impaired biological tissues or for cosmetic purposes. In one example of the present invention, the cells are cells used as a therapeutic agent for arthritis. For example, the cells may be cells used as a therapeutic agent for meniscus or osteoarthritis.

[0052] As an example, the use of synovial membrane-derived mesenchymal stem cells as a therapeutic agent for arthritis (such as a therapeutic agent for osteoarthritis) or meniscus will be described below.

[0053] Synovial tissue can be harvested from a joint under anesthesia. The excised synovial tissue is enzymatically treated with a protease such as collagenase or trypsin, and the treated cells are filtered through a mesh filter. Nucleated cells collected by the above method can be selected for quality control in the method of the present invention, and the selected cells can be used for therapy.

[0054] Synovium-derived mesenchymal stem cells can be cultured and expanded ex vivo without prior differentiation induction using a differentiation medium. The undifferentiated synovium-derived mesenchymal stem cells expanded in this way can be transplanted into patients. To achieve efficient treatment, 10 cm 2 Preferably, 5 × 10 cells / ml are used per cartilage defect or meniscus defect of about the same size. 7 or more, more preferably 1×10 8 At least one mesenchymal stem cell may be transplanted.

[0055] In another example of the present invention, the cells can be used for drug discovery. As an example, cells whose quality has been controlled by the method of the present invention can be used to evaluate the efficacy or toxicity of candidate drugs and screen the candidate drugs. For example, the efficacy or toxicity of the candidate drug can be evaluated by comparing the characteristics of the cells when the candidate drug is contacted with the cells with those when the candidate drug is not contacted.

[0056] The present invention will be explained in more detail with reference to the following examples, but the present invention is not limited to these examples. [Example]

[0057] In Examples 1 to 5, a meniscus injury model was created, and specific protein molecules essential for the therapeutic effect of synovial stem cells were inhibited to identify and demonstrate the specific protein molecules essential for the drug's efficacy. The specific protein molecules were inhibited using cells inhibited with antibodies against the specific protein molecules, or using cells in which the specific protein molecules had been deleted by gene knockout. If the meniscus regeneration effect was significantly reduced, it could be demonstrated that the specific protein molecules were essential for the drug's efficacy.

[0058] Example 1: Preparation of synovial stem cells as therapeutic cells Five-week-old Lewis rats were used to establish synovial-derived mesenchymal stem cells. Synovial tissue was collected under isoflurane anesthesia. Collagenase V (Sigma Cat# C9263) was added to mMEMα with L-Alanyl-L-Glutamine, Phenol Red, and Sodium Pyruvate (Fujifilm WAKO Cat# 282-98675) medium at 2.0 mg / mL, supplemented with fetal bovine serum (Gibco Cat# 10270) at a concentration of 20% and antibiotic-antimycotic (100X) (Thermofisher Scientific Cat# 15240062) at a concentration of 1%, and incubated at 37°C for 2 hours. The reaction was stopped by adding chilled medium, and the cells were passed through a 40 μm cell strainer to remove residual tissue. The collected cells were then strained into a 75 cm 2 The cells were seeded into cell culture flasks (Corning Inc., model number: 353136) and cultured for 8 days at 37°C with a 5% CO2 concentration. After 8 days of culture, the medium in the flask was discarded and the flask was washed twice with phosphate-buffered saline (PBS). 4 mL of TrypLE Express (Thermo Fisher) was added and the flask was left to stand in a 37°C incubator for 5 minutes. The cells were then collected as mesenchymal stem cells, and the cell count was calculated using a Vi-CELL (Beckman Coulter, model number: 731050) viable cell autoanalyzer. The supernatant was discarded by centrifugation and transferred to a COS banker to create a frozen stock of synovial stem cells.

[0059] Example 2: Preparation of a meniscus injury model Ten-week-old Lewis rats were used to create a meniscus injury model to evaluate the meniscus regeneration effect. Meniscus injury and mesenchymal stem cell transplantation were performed by incising the skin over the knee joint under isoflurane anesthesia to expose the knee joint. The medial infrapatellar joint capsule was exposed and then incised longitudinally with a scalpel to expose the cartilage at the distal femur. The medial meniscus was detached from the synovial membrane, and approximately two-thirds of the medial meniscus was excised. The patellar tendon and synovial membrane were sutured, followed by muscle sutures. After meniscus injury treatment, the rats were divided into two groups: a group treated with rat synovial membrane-derived mesenchymal stem cells (synovial stem cells) prepared in Example 1 and a control group treated with PBS. For the synovial stem cell group, mesenchymal stem cells were established and frozen from the synovium. They were incubated for one week in mMEMα with L-Alanyl-L-Glutamine, Phenol Red, and Sodium Pyruvate (Fujifilm WAKO Cat# 282-98675) containing 20% ​​Fetal Bovine Serum (Gibco Cat# 10270) and 1% Antibiotic-Antimycotic (100X) (Thermofisher Scientific Cat# 15240062). 5x10 cells were collected. 6 The cells were implanted into the knee joint using a syringe needle, perpendicular to the knee joint, through the suture site, and the skin was sutured. After surgery, all rats were returned to their cages and allowed to exercise and eat and drink freely. Three weeks after the procedure, animals were necropsied. Under isoflurane anesthesia, the animals were euthanized by exsanguination via infraaortic section. The knee joint was then dislocated to expose the meniscus, and the medial meniscus was excised and photographed. Images of the excised medial meniscus from both knee joints are shown in Figure 1. The regenerated area was identified in the image based on differences in color and shape from the normal meniscus and outlined. While half of the menisci in the PBS group had regenerated to the mid-phalangeal region, many of the menisci in the synovial stem cell group regenerated to the anterior phalangeal region, confirming the effectiveness of synovial stem cell transplantation in meniscal regeneration.

[0060] To quantitatively compare the meniscus regeneration effect between the synovial stem cell group and the PBS group, the area of ​​the regenerated meniscus (within the line) was measured using ImageJ (version 1.52). The regenerated meniscus was visually determined based on the color and shape of the meniscus, and the area was calculated using the following formula.

[0061] Meniscal regeneration area (mm 2 ) = Number of pixels in the meniscus regeneration area / 1mm 2 Pixels per

[0062] The mean values, standard deviations, and statistical analyses of the regenerated areas for each group were all performed using Microsoft Excel® 2007 (Microsoft Corp.). Statistical analysis was performed using Student's T-Test between the synovial stem cell group and the PBS group, with a significance level of less than 5% (P<0.05) considered to indicate a difference.

[0063] The regenerated meniscus area values ​​for the synovial stem cell group and the PBS group are shown in Table 1. The regenerated meniscus area for the PBS group was 1.1 mm 2 In contrast, the synovial stem cell group had a mean of 2.0 mm 2 The regenerated area was approximately twice as large as that of the control group, demonstrating a statistically significant difference (P<0.01). This demonstrated that synovial stem cells are effective in meniscus regeneration therapy. In the following examples, specific protein molecules essential for efficacy were identified and demonstrated by administering cells in which specific protein molecules had been inhibited to the meniscus injury model described in this example.

[0064] [Table 1]

[0065] Example 3: Preparation of synovial stem cells by inhibiting specific proteins and evaluation of efficacy in a meniscus injury model For the synovial stem cells obtained in Example 1, neutralizing antibodies for the surface antigen CD29 (BioLegend Cat# 102202), the surface antigen CD140b (R&D Systems Cat# AF385), and the surface antigen CD44 (Absolute Antibody Cat# Ab00628-23.0) were prepared and incubated with each of these antibodies individually to prepare synovial stem cells inhibiting the corresponding specific protein molecules. These antibodies were designated CD29-inhibited synovial stem cells, CD140b-inhibited synovial stem cells, and CD44-inhibited synovial stem cells, respectively. Simultaneously, IgG-reactive synovial stem cells were incubated with synovial stem cells that do not exhibit molecular inhibition against synovial stem cells to prepare IgG-reactive synovial stem cells as controls. These cells were administered to a meniscus injury model as in Example 2, and the area of ​​meniscus regeneration after 3 weeks was measured as in Example 2. The results are shown in Figure 2.

[0066] The results showed that CD29-inhibited synovial stem cells had a statistically significant loss of therapeutic efficacy for meniscus regeneration compared to IgG-reactive synovial stem cells. Similarly, CD140b-inhibited synovial stem cells had a statistically significant decrease in therapeutic efficacy for meniscus regeneration compared to IgG-reactive synovial stem cells. These results identified CD29 and CD140b as specific protein molecules essential for drug efficacy. On the other hand, CD44-inhibited synovial stem cells did not show a significant decrease in therapeutic efficacy for meniscus regeneration compared to IgG-reactive synovial stem cells. This indicates that CD44 cannot be considered a specific protein molecule essential for drug efficacy.

[0067] Example 4: Preparation of synovial stem cells lacking specific proteins by gene knockout and evaluation of efficacy in a meniscus injury model The synovial stem cells obtained in Example 1 were subjected to gene knockout of TNFαR1, VCAM1, and Col2a1 individually. As a result, synovial stem cells in which the specific protein molecules TNFαR1, VCAM1, and Col2a1 were individually deleted were prepared: TNFαR1 knockout synovial stem cells, VCAM1 knockout synovial stem cells, and Col2a1 knockout synovial stem cells. These cells were compared for meniscus regeneration effects with non-knockout control cells, TNFαR1WT synovial stem cells, VCAM1WT synovial stem cells, and Col2a1WT synovial stem cells, using a meniscus injury model. The meniscus regeneration effects were evaluated in the same manner as in Example 2: each cell was administered to a meniscus injury model, and the area of ​​the regenerated meniscus after 3 weeks was measured in the same manner as in Example 2. The results are shown in Figure 3.

[0068] As a result, TNFαR1 knockout synovial stem cells showed no statistically significant difference compared to non-knockout synovial stem cells, and the therapeutic effect of meniscus regeneration was not reduced. VCAM1 knockout synovial stem cells also showed no statistically significant difference compared to non-knockout synovial stem cells, and the therapeutic effect of meniscus regeneration was not reduced. These results indicate that TNFαR1 and VCAM1 cannot be considered specific protein molecules essential for drug efficacy. On the other hand, Col2a1 knockout synovial stem cells showed a statistically significant decrease in the therapeutic effect of meniscus regeneration compared to non-knockout synovial stem cells. These results indicate that Col2a1 is a specific protein molecule essential for drug efficacy.

[0069] Example 5: The synovial stem cells obtained in Example 1 were measured by flow cytometry for the positivity rates of CD29 and CD140b, protein molecules essential for the efficacy identified in Example 3. The antibodies used were CD29 (PE anti-mouse / rat CD29 antibody, BioLegend Cat#102207) and CD140b (anti-PDGF receptor β, human, goat-poly, R&D Systems Cat#AF385), respectively.

[0070] As a result, the surface antigen positivity rate for CD29 was found to be 98.7%, and that for CD140b was 91.6%. Based on this, it was found that the standard values ​​for CD29 and CD140b should be 90% or more and 80% or more, respectively.

[0071] We also measured the positivity of CD29 and CD140b, proteins essential for drug efficacy, by flow cytometry using human synovial stem cells (Cryopreserved Synoviocytes, Normal, P1, product number: CDD-H-2910-N, lots: ST1414, ST1420, ST1434, ST1462) purchased from Articular Engineering. The antibodies used were CD29 (APC Mouse Anti-Human CD29 Cat: 559883) and CD140b (Anti-PDGF Receptor β, Human, Goat-Poly Cat: AF385), respectively.

[0072] The CD29 surface antigen positivity rates were 99.4%, 99.6%, 99.6%, and 99.5% for each lot. The CD140b surface antigen positivity rates were 92.2%, 90.7%, 95.2%, and 85.9% for each lot. Based on these results, it was found that the appropriate standard values ​​for CD29 and CD140b are 90% or higher and 80% or higher, respectively.

[0073] In the following Examples 6 to 10, we selected the expression of related genes that characterize cell populations, regardless of whether they are essential for drug efficacy, and demonstrated that by using the expression patterns of these genes, cell populations can be classified and managed based on correlations.

[0074] Example 6: Cell preparation and mRNA sample preparation for each cell Example 6-1: Preparation of MSC cells and their mRNA (1)Cell The following cells were prepared:

[0075] Synovial MSCs: Preparation of synovial stem cells (commercially available) (4 lots) Frozen synovial membrane-derived stem cells (Cryopreserved Synoviocytes, Normal, P1, model number: CDD-H-2910-N, lots: ST1414, ST1420, ST1434, ST1462) purchased from Articular Engineering were used.

[0076] L Bone marrow MSC: Preparation of bone marrow-derived mesenchymal stem cells (manufactured by Lonza) (3 lots) Bone marrow-derived mesenchymal stem cells (Mesenchymal Stem cells cryo amp model number: PT-2501, lot: 18TL241909, 0000494678, 19TL155677) purchased from LONZA were used.

[0077] J Bone Marrow MSC: Preparation of bone marrow-derived mesenchymal stem cells (manufactured by J-TEC) (3 lots) Bone marrow-derived mesenchymal stem cells (lot number: BKXH) produced by Japan Tissue Engineering (J-TEC) were used.

[0078] F bone marrow MSC: Preparation of bone marrow-derived mesenchymal stem cells (FF) (3 lots) Bone marrow-derived mesenchymal stem cells isolated from bone marrow fluid (Whole Bone Marrow, Fresh, 10 mL, model number: ALL-ABM001, lot numbers: 3024624, 3024625) purchased from Allcells were used.

[0079] REC-MSC: Preparation of bone marrow-derived mesenchymal stem cells (REC: manufactured by PuREC) (3 lots) Ultra-high purity human mesenchymal stem cells (REC) purchased from PUREC (product number: 387-16591, lot numbers: 050780614, 200370207, 111090605) were used.

[0080] iPSC-MSC: Preparation of iPSC-derived mesenchymal stem cells (FCDI) (1 lot) iCell mesenchymal stem cells (model number: R1098, lot number: 0004) purchased from FUJIFILM Cellular Dynamics were used.

[0081] L Adipose MSC: Preparation of adipose-derived mesenchymal stem cells (manufactured by Lonza) (3 lots) Adipose-derived mesenchymal stem cells (Adipose-Derived Stem cells (amp) model number: PT-5606, lot: 18TL241909, 0000494678, 19TL155677) purchased from LONZA were used.

[0082] (2) Culture medium Basal medium: MEMα (containing L-alanyl-L-glutamine, phenol red, and sodium pyruvate) (product number: 289-33365, lot number: SKH9471) supplemented with 20 μg / mL of gentamicin sulfate (Takada Pharmaceutical Gentacin Injection 60) as an antibiotic and fetal bovine serum (Selborne, product number: FBS-04) to a final concentration of 15% (v / v). Hereinafter, this medium will be referred to as the culture medium.

[0083] (3) Isolation of bone marrow-derived mesenchymal stem cells from bone marrow aspirate (Allcells bone marrow aspirate-derived mesenchymal stem cells) To isolate mesenchymal stem cells, purchased bone marrow fluid (lots: 3024624, 3024625) was centrifuged at 1000 rpm for 10 minutes, and the plasma was removed. Culture medium was added to the supernatant at a volume 10 times that before plasma removal, and the medium was diluted at 0.20 mL / cm. 2The cells were seeded into flasks so that the total volume was 1000 ml and cultured in an incubator at 37°C in a 5% CO2 atmosphere. The medium was changed every 3 or 4 days, and after 12 to 13 days of culture from seeding, the cells were detached using a 0.05% trypsin-EDTA (ethylenediaminetetraacetic acid) solution (hereafter referred to as trypsin, Life Technologies model number: 25300). After detachment, the trypsin was neutralized with an equal volume of medium and transferred to a separate tube. The culture flask was further rinsed with an equal volume of medium and added to the above tube to recover the remaining cells. The tube was centrifuged at 200 × g for 5 minutes, and the supernatant was removed. An appropriate volume of medium was added to the remaining pellet, and the cells were counted using a hemocytometer. The final concentration was 0.20 to 0.50 × 10 4 cells / cm 2 The cells were seeded into flasks so that the cells would reach a final concentration of 10% (v / v) dimethyl sulfoxide (SIGMA-ALDRICH, model number: D2650) in a final concentration of 100 × 10 cells / ml. After culturing for 3 or 4 days, when the cells had filled 60% or more of the bottom of the flask, subculture was repeated using the same procedure as above. At the end of the second subculture, the cells were centrifuged and frozen at 100 × 10 cells / ml in a freezing solution mixed with culture medium to a final concentration of 10% (v / v) dimethyl sulfoxide (SIGMA-ALDRICH, model number: D2650). 4 The concentration was adjusted to cells / mL.

[0084] (4) Cultivation of mesenchymal stem cells and gene extraction The mesenchymal stem cells (seven types, 17 lots in total) prepared had different recommended media, but to minimize the influence of the media on genetic analysis, each cell was cultured using the culture media described in (2) above. Frozen stocks of each MSC were thawed in a 37°C water bath, centrifuged at 200 × g for 5 minutes, the frozen solution was removed, and the respective media was added. The cells were cultured at 0.25–0.50 × 10 4 cells / cm 2The cells were seeded into flasks so that the total volume was 1000 ml and cultured in an incubator at 37°C in a 5% CO2 atmosphere for 3 or 4 days. When the cells filled more than 60% of the flask bottom, they were passaged twice using the method described above. The collected cells were added to a lysis buffer containing QIAGEN RNeasy (QIAGEN, 74104) RLT Buffer supplemented with DTT (Wako, 047-08973) and mixed by pipetting to prepare lysate, which was then stored at -80°C. RNA extraction was performed according to the QIAGEN protocol. The nucleic acid concentration of the resulting RNA solution was measured, and the solution was diluted as necessary.

[0085] Example 6-2: Regulation of non-MSC cells and their mRNA (1)Cell The following cells were prepared: LONZA Fibroblast (FB) CC-2509 ATCC Pulmonary artery endothelial cells (PAEC) PCS-100-022 PromoCell Visceral Fat Cells (WP) C-12732 PromoCell Chondrocyte (CH)C-12710 PromoCell Hematopoietic Progenitor Cells (CD34 Cells) C-12921 LONZA T cell 2W-200 ATCC Bcell PCS-800-018 PromoCell Monocytes (CD14 cells) C-12909 Peripheral blood-derived iPSC cells (iPSC)

[0086] (2) Preparation of cells other than mesenchymal stem cells and gene extraction Frozen vials of fibroblasts, pulmonary artery endothelial cells, visceral adipocytes, chondrocytes, hematopoietic progenitor cells, and monocytes were thawed in a 37°C water bath and slowly added to 10 mL of prewarmed MEMα / 15% FBS / 20 μg / mL gentamicin medium. Cell counting was performed. After centrifugation (300xG, 5 minutes, room temperature), the supernatant was removed as much as possible. Lysis buffer containing DTT (Wako, 047-08973) in QIAGEN RNeasy (QIAGEN, 74104) RLT buffer was added and mixed by pipetting to prepare lysates. 350 μL of the lysate was transferred to 1.5 mL tubes for RNA extraction.

[0087] T cells were thawed in a 37°C water bath and transferred to a 50ml conical tube. 1mL of warmed RPMI / NEAA / 1mmol / L sodium pyruvate / 2mmol / L L-alanine & L-glutammine / 10mmol / L HEPES / 10% FBS / 20U / mL DNase I was slowly added. 1mL of the warmed medium was transferred to the empty vial, and the rinse solution was added to the 50mL tube over 1-2 minutes, with repeated gentle agitation. A few drops of the medium were added to the tube, with repeated gentle agitation, over several minutes until the final volume reached 50mL. After cell counting, the tube was centrifuged (300xG, 5 minutes, room temperature), and the supernatant was removed as much as possible. RLT / DTT+ was added and the tube was mixed by pipetting. 350µL of the lysate was transferred to a 1.5mL tube for RNA extraction.

[0088] Frozen B cells were thawed from a vial in a 37°C water bath and slowly added to 5 mL of pre-warmed HBSS / 10 & HSA, followed by cell counting. After centrifugation (300 x G, 5 minutes, room temperature), the supernatant was removed as much as possible, and RLT / DTT+ was added and mixed by pipetting. 350 μL of the lysate was transferred to 1.5 mL tubes for RNA extraction.

[0089] iPS cells were cultured in a 6-well plate, and after removing the supernatant, 350 μL / well of RLT / DTT+ was added and lysed by pipetting. The lysate from one well was placed in one 1.5 mL tube and subjected to RNA extraction.

[0090] The number of cells used for each RNA extraction was 4x10 6 The volume of the lysate was not to exceed 1000 ml. If RNA extraction was not performed immediately after lysate preparation, it was stored at -80°C and thawed on ice on the day of RNA extraction before use. RNA extraction was performed according to the QIAGEN protocol. The nucleic acid concentration of the resulting RNA solution was measured, and it was diluted as necessary.

[0091] Example 7: Creation of a gene expression pattern panel (1) Selection of genes characteristic of MSCs Amplicon sequencing has been shown to be able to accurately measure up to 1,200 genes. Therefore, we narrowed down the genes that are considered to be markers for MSC function and status to 1,200 genes and constructed a high-throughput evaluation system. As items for evaluating MSC function and status, we selected 16 items related to MSCs, based on commercially available gene expression analysis panels (Table 2).

[0092] To select genes, we used commercially available panels (Thermo, Illumina, Qiagen, BIO-RAD), literature, microarray data, and the Ontology database (http: / / www.informatics.jax.org / vocab / gene_ontology / ) to select frequently appearing genes for each of the 16 items.

[0093] [Table 2]

[0094] As a result, genes were selected based on frequency of appearance from 26 commercially available panels, 294 literature reports, the Ontology database, and microarray data. After sorting out overlapping genes for each category, a total of 1,107 genes were extracted. 92 genes were then selected from the microarray data. The remaining gene, GAPDH, was selected as a house keeping gene, bringing the total to 1,200 genes. The gene selection method for each category and the selected genes are shown below.

[0095] <1> Selection of bone formation-related genes A total of 477 genes were extracted: 84 from Qiagen's PAHS-049Z "Osteogenesis PCR Array," 392 from the Ontology database (Osteogenesis), and 92 from 23 literature reports on MSC and Osteogenesis. Eleven differentiation prediction markers were added, and 96 genes were selected by prioritizing their frequency of appearance.

[0096] <2> Selection of adipogenesis-related genes A total of 354 genes were extracted: 84 from Qiagen's PAHS-026Z "Adipogenesis PCR Array," 270 from the Ontology database (adipogenesis), and 97 from 23 literature reports on MSCs and adipogenesis. Nine differentiation prediction markers were added, and 101 genes were selected by prioritizing their frequency of appearance.

[0097] <3> Selection of chondrogenesis-related genes As there were no commercially available panels related to cartilage, a selection was made based on the ontology database, cartilage markers from R&D Systems, literature, and cartilage matrix. A total of 398 genes were extracted: 214 from the ontology database (chondrogenesis), 30 from the R&D Systems website, 249 from 52 papers on MSC and chondrogenesis, and 14 from cartilage matrix. 119 genes were selected by prioritizing their frequency of appearance.

[0098] <4> Selection of immune-related genes The following three commercially available panels were selected: Qiagen PAHS-052Z "Innate & Adaptive Immune Response PCR Array" (84 types), Thermo Scientific #4414073 "TaqMan TM A total of 512 genes were extracted from 107 sources (96 from the "Array Human Immune Response" and 401 from the Illumina #20019169 "AmpliSeq for Illumina Immune Response Panel") and 15 publications related to MSCs and immunity. 282 genes were selected based on frequency of appearance.

[0099] <5> Selection of inflammation-related genes 798 types were analyzed using six commercially available panels (Qiagen PAHS-011Z "Inflammatory Cytokines & Receptors PCR Array," Qiagen PAHS-3803Z "Inflammatory Response and Autoimmunity 384H," Thermo EPX200-12185-901 "Inflammation 20-Plex Human ProcartaPlex"). TMPanel,” Illumina #20020496 “AmpliSeq for Illumina RNA Inflammation Response Research Panel,” BIO-RAD #171AL001M “Bio-Plex Pro Human Inflammation Assay Kit,” and BIO-RAD #12007283 “Bio-Plex Pro TM A total of 1,257 genes were extracted, including 715 from the Human Cytokine Screening 48-Plex Panel, the Ontology database (inflammatory response), and 110 from 29 literature articles on MSCs and anti-inflammation. 303 genes were selected based on frequency of appearance.

[0100] <6> Selection of angiogenesis-related genes 166 samples were collected from three commercially available panels: Qiagen PAHS-024Z "Angiogenesis PCR Array," Qiagen PAHS-072Z "Angiogenic Growth Factors PCR Array," and Thermo Scientific #4414071 "TaqMan TM A total of 647 genes were extracted, including 531 from the Array Human Angiogenesis (http: / / www.msc.go.jp / msc / human_angiogenesis / ), the Ontology database (angiogenesis), and 179 from 15 literature articles on MSC angiogenesis. 121 genes were selected based on their frequency of appearance.

[0101] <7> Selection of nerve regeneration-related genes 246 samples were collected from three commercially available panels: Qiagen PAHS-404Z "Neurogenesis PCR Array" (84 samples), Qiagen PAHS-031Z "Neurotrophin and Receptors PCR Array" (84 samples), and Thermo Scientific #4414094 "TaqMan TMA total of 380 genes were extracted from the Array Human Neurotransmitters (92 genes), 80 genes from the Ontology database (nerve development), and 92 genes from 16 literature articles on MSCs and nerve regeneration. 109 genes were selected based on their frequency of appearance.

[0102] <8> Selection of fibrosis-related genes A total of 346 genes were extracted: 84 from the Qiagen PAHS-026Z "Fibrosis PCR Array," 268 from the Ontology database (collagen metabolic process (GO:0032963), fibroblast proliferation (GO:0048144), connective tissue replacement (GO:0097709), and fibroblast migration (GO:0010761), and 59 from 19 literature reports on MSC fibrosis. 112 genes were selected by prioritizing their frequency of appearance.

[0103] <9> Selection of immunogenicity-related genes Since there were no commercially available panels regarding immunogenicity, a total of 42 genes were selected from 20 literature reports.

[0104] <10> Selection of migration-related genes A total of 199 genes were extracted: 84 from the Qiagen PAHS-128Z "Cell Motility PCR Array," 925 from the Ontology database (negative regulation of cell migration (GO:0030336), positive regulation of cell migration (GO:0030335), regulation of cell migration (GO:0030334), and mesenchymal stem cell migration (GO:1905319), and 137 from 15 literature articles on MSC migration. However, due to the large number of genes in the ontology, genes that only appeared in the ontology were excluded. 137 genes were selected by prioritizing their frequency of appearance.

[0105] <11> Selection of adhesion-related genes Thermo #4418778 "TaqMan TM A total of 138 genes were extracted: 92 from the "Array, Human Extracellular Matrix & Adhesion Molecules," 952 from 14 other items in the Ontology database, including cell adhesion mediated by integrin (GO:0033627), negative regulation of cell adhesion (GO:0007162), positive regulation of cell adhesion (GO:0045785), and regulation of cell adhesion (GO:0030155), 78 from 16 literature reports on MSC adhesion / engraftment, and 34 from adhesion molecules. However, due to the large number of genes in the ontology, genes that only appeared in the ontology were excluded. 95 genes were selected by prioritizing their frequency of appearance.

[0106] <12> Selection of aging-related genes A total of 493 genes were extracted: 163 from two commercially available panels (84 from Qiagen PAHS-178Z "Aging PCR Array" and 84 from Qiagen PAHS-050Z "Cellular Senescence PCR Array"), 153 from the Ontology database; Cell aging (GO:0007569), and 273 from 20 literature articles on MSC aging. 113 genes were selected based on frequency of appearance.

[0107] <13> , <14> Selection of growth factor and cytokine-related genes The genes in the growth factor and cytokine categories were selected together because they were similar. We extracted 144 genes from two commercially available panels (Qiagen PAHS-041Z "Growth Factor PCR Array" 84 genes and Qiagen PAHS-150Z "Cytokines and Chemokines PCR Array" 84 genes), 205 genes from 15 literature studies on growth factors and cytokines secreted by MSCs, and 38 cytokines detected by the R&D Systems Proteome Profiler Human XL Cytokine Array Kit (product number: ARY022) on a LAS-3000 (GE Healthcare) following the procedure described above. A total of 350 genes were extracted. 177 genes were selected based on frequency of appearance.

[0108] <15> Selection of MSC marker-related genes A total of 212 genes were extracted: 84 from Qiagen's PAHS-082Z "Mesenchymal Stem Cell PCR Array" and 165 from 16 literature reports on MSC markers. 110 genes were selected based on frequency of appearance.

[0109] <16> Selection of surface marker-related genes 90 types of MSCs were selected from Qiagen's PAHS-055Z "Cell Surface Markers PCR Array," 101 types of MSCs from the candidate gene group not selected by the MSC markers, and J bone marrow MSCs, F bone marrow MSCs, and iPSC-MSCs were passaged up to P6 using the above method and cultured on BD's Lyoplate TM From the data obtained by comprehensively analyzing 242 surface markers using the Human Cell Surface Marker Screening Panel (product number: 560747), priorities were set based on two criteria: high positive rates (50% or higher) and large differences in values ​​between samples (50% or higher). The procedure was carried out according to the protocol, and detection was performed using Thermo Fisher Scientific's Attune NxT. A total of 348 genes were extracted. 87 genes were selected based on their frequency of appearance.

[0110] <1200 selected genes> ABCB1(ATP-binding cassette, sub-family B (MDR / TAP), member 1A)、Abl1(c-abl oncogene 1, non-receptor tyrosine kinase)、ACACB(acetyl-Coenzyme A carboxylase beta)、Acan(aggrecan)、ACHE(acetylcholinesterase)、Ackr2(atypical chemokine receptor 2)、ackr3(atypical chemokine receptor 3)、ACLY(ATP citrate lyase)、ACTA2(Actin, alpha 2, smooth muscle, aorta)、ACTB(actin, beta)、ACTG2(actin, gamma 2, smooth muscle, enteric)、ACTN3(actinin alpha 3)、ACTR2(ARP2 actin-related protein 2)、ACTR3(ARP3 actin-related protein 3)、Acvr1(activin A receptor, type 1)、Acvr2a(activin receptor IIA)、Acvr2b(activin receptor IIB)、ADAMTS1(a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1)、ADAMTS5(a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) )、Adgrb1(adhesion G protein-coupled receptor B1)、Adig(adipogenin)、Adipoq(adiponectin,C1Q and collagen domain containing)、Adora1(adenosine A1 receptor)、Adora2a(adenosine A2a receptor)、Adrb2(adrenergic receptor, beta 2)、Afap1l2(actin filament associated protein 1-like 2)、Ager(advanced glycosylation end-product specific receptor)、AgRP(Agouti related protein)、AGT(angiotensinogen (serpin peptidase inhibitor, clade A, member 8) )、Ahsg(alpha-2-HS-glycoprotein)、Aif1(allograft inflammatory factor1)、Aimp1(aminoacyl tRNA synthetase complex-interacting multifunctional protein 1)、Akt1(thymoma viral proto-oncogene 1)、Akt3(thymoma viral proto-oncogene 3)、Alcam(activated leukocyte cell adhesion molecule)、Alox15(arachidonate 15-lipoxygenase)、Alox5(arachidonate 5-lipoxygenase)、Alox5ap(arachidonate 5-lipoxygenase activating protein)、Alpl(alkaline phosphatase,liver / bone / kidney)、AMOT(Angiomotin)、Ang(Angiogenin)、ANGEL2(angel homolog 2)、ANGPT1(angiopoietin 1)、ANGPT2(angiopoietin 2)、ANGPT4(angiopoietin 4)、ANGPTL1(Angiopoietin-like 1)、ANGPTL3(Angiopoietin-like 3)、ANGPTL4(Angiopoietin-like 4)、ANPEP(Alanyl (membrane) aminopeptidase)、Anxa1(annexin A1)、ANXA3(annexin A3)、ANXA5(annexin A5)、Anxa6(annexin A6)、Aoah(acyloxyacyl hydrolase)、Aoc3(amine oxidase, copper containing 3)、APAF1(apoptotic peptidase activating factor 1)、APBA1(amyloid beta (A4) precursor protein binding, family A, member 1)、APBA2(amyloid beta (A4) precursor protein-binding, family A, member 2)、Apoa1(apolipoprotein A-I)、, APOE(apolipoprotein E)、Areg(Amphiregulin)、ARF6(ADP-ribosylation factor 6)、 ARG1(arginase, liver)、ARG2(arginase type II)、Arhgap29(Rho GTPase activating protein 29)、ARHGAP35(Rho GTPase activating protein 35)、ARL6IP6(ADP-ribosylation factor-like 6 interacting protein 6)、Artn(Artemin)、Atm(ataxia telangiectasia mutated)、Atrn(attractin)、AURKB(aurora kinase B)、 Axin1(axin 1)、Axl(AXL receptor tyrosine kinase)、B2M(beta-2 microglobulin)、B3gat1(beta-1,3-glucuronyltransferase 1)、B4GALNT1(beta-1,4-N-acetyl-galactosaminyltransferase 1)、B4galt1(UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1)、BAIAP2(brain-specific angiogenesis inhibitor 1-associated protein 2)、BCAR1(breast cancer anti-estrogen resistance 1)、BCL2(B cell leukemia / lymphoma 2)、Bcl6(B cell leukemia / lymphoma 6)、 Bdkrb1(bradykinin receptor, beta 1)、Bdkrb2(bradykinin receptor, beta 2)、BDNF(Brain-derived neurotrophic factor)、Bglap(bone gamma carboxyglutamate protein)、BGN(biglycan)、BMI1(Bmi1 polycomb ring finger oncogene)、Bmp1(bone morphogenetic protein 1)、Bmp2(bone morphogenetic protein 2)、Bmp3(bone morphogenetic protein 3)、Bmp4(bone morphogenetic protein 4)、Bmp5(bone morphogenetic protein 5)、Bmp6(bone morphogenetic protein 6)、Bmp7(bone morphogenetic protein 7)、Bmpr1a(bone morphogenetic protein receptor, type 1A)、Bmpr1b(bone morphogenetic protein receptor, type 1B)、Bmpr2(bone morphogenetic protein receptor, type II (serine / threonine kinase) )、Bsg(basigin)、BST1(bone marrow stromal cell antigen 1)、BTC(Betacellulin)、Btk(Bruton agammaglobulinemia tyrosine kinase)、BTLA (B and T lymphocyte associated)、Btn2a2(butyrophilin, subfamily 2, member A2)、C1qa(complement component 1, q subcomponent, alpha polypeptide)、C1QC(complement component 1, q subcomponent, C chain)、C1R(complement component 1,r subcomponent A)、C1S(complement component 1, s subcomponent 1)、C2cd4a(C2 calcium-dependent domain containing 4A)、C3(complement component 3)、C3ar1(complement component 3a receptor 1)、Cadm1(cell adhesion molecule 1)、CALB1(calbindin 1)、Calcr(calcitonin receptor)Calr(calreticulin)、, Camp(cathelicidin antimicrobial peptide)、CAPN2(calpain 2)、Casp1(caspase 1)、CASP3(Caspase 3, apoptosis-related cysteine peptidase)、CAV1(caveolin 1)、CBLN2(cerebellin 2 precursor protein)、CCL1(chemokine (C-C motif) ligand 1)、CCL11(chemokine (C-C motif) ligand 11)、CCL13(chemokine (C-C motif) ligand 13)、CCL15(chemokine (C-C motif) ligand 15)、CCL16(chemokine (C-C motif) ligand 16)、CCL17(chemokine (C-C motif) ligand 17)、CCL18(chemokine (C-C motif) ligand 18)、CCL19(chemokine (C-C motif) ligand 19)、CCL2(chemokine (C-C motif) ligand 2)、Ccl20(chemokine (C-C motif) ligand 20)、CCL21(chemokine (C-C motif) ligand 21)、CCL22(chemokine (C-C motif) ligand 22)、CCL23(chemokine (C-C motif) ligand 23)、CCL24(chemokine (C-C motif) ligand 24)、CCL25(chemokine (C-C motif) ligand 25)、CCL26(chemokine (C-C motif) ligand 26)、CCL27(chemokine (C-C motif) ligand 27)、CCL3(chemokine (C-C motif) ligand 3)、CCL4(chemokine (C-C motif) ligand 4)、CCL5(chemokine (C-C motif) ligand 5)、CCL7(chemokine (C-C motif) ligand7)、CCL8(chemokine (C-C motif) ligand 8)、Ccn1(cellular communication network factor 1)、Ccn2(cellular communication network factor 2)、Ccn3(cellular communication network factor 3)、Ccn4(cellular communication network factor 4)、Ccnd1(cyclin D1)、Ccr1(chemokine (C-C motif) receptor 1)、CCR10(chemokine (C-C motif) receptor 10)、CCR2(chemokine (C-C motif) receptor 2)、CCR3(chemokine (C-C motif) receptor 3)、CCR4(chemokine (C-C motif) receptor 4)、CCR5(chemokine (C-C motif) receptor 5)、CCR6(chemokine (C-C motif) receptor 6)、CCR7(chemokine (C-C motif) receptor 7)、CCR8(chemokine (C-C motif) receptor 8)、CCR9(chemokine (C-C motif) receptor 9)、Ccrl2(chemokine (C-C motif) receptor-like 2)、CD14(CD14 antigen)、CD151(CD151 antigen)、CD160(CD160 antigen)、CD163(CD163 antigen)、CD164(CD164 antigen)、CD165(CD165 antigen)、CD180(CD180 antigen)、CD19(CD19 antigen)、CD1B(CD1b molecule)、CD1C(CD1c molecule)、CD1D(CD1d molecule)、CD2(CD2 antigen)、CD200(CD200 antigen)、CD209(CD209 molecule)、CD22(CD22 molecule)、CD226(CD226molecule)、CD24(CD24 molecule)、CD244(CD244 molecule, natural killer cell receptor 2B4)、CD247(CD247 molecule)、CD248(CD248 antigen, endosialin)、CD27(CD27 molecule)、CD274(CD274 antigen)、CD276(CD276 antigen)、CD28(CD28 antigen)、CD33(CD33 antigen)、CD34(CD34 antigen)、CD36(CD36 molecule)、CD37(CD37 molecule)、CD38(CD38 antigen)、CD3D(CD3d molecule)、CD3E(CD3 antigen, epsilon polypeptide)、CD3G(CD3g molecule)、CD4(CD4 antigen)、CD40(CD40 antigen)、CD40lg(CD40 ligand)、CD44(CD44 antigen)、 CD47(CD47 antigen (Rh-related antigen, integrin-associated signal transducer) )、CD48(CD48 antigen)、CD52(CD52 molecule)、CD53(CD53 molecule)、CD55(CD55 molecule)、CD58(CD58 molecule)、CD59(CD59 molecule)、CD6(CD6 molecule)、CD63(CD63 molecule)、CD68(CD68 antigen)、CD69(CD69 molecule)、CD70(CD70 antigen)、CD74(CD74 antigen)、CD79A(CD79a molecule, immunoglobulin-associated alpha)、CD79B(CD79b molecule, immunoglobulin-associated beta)、CD80(CD80 antigen)、CD83(CD83 molecule)、CD86(CD86 antigen)、CD8A(CD8 antigen, alpha chain)、CD8B(CD8b molecule)、CD9(CD9 antigen)、CD93(CD93 antigen)、CD99(CD99 antigen)、CDH1(cadherin 1)、CDH11(cadherin 11)、CDH2(cadherin 2)、CDH3(cadherin 3)、CDH4(cadherin 4)、CDH5(Cadherin 5,type 2 (vascular endothelium) )、CDK4(cyclin-dependent kinase 4)、CDK6(cyclin-dependent kinase 6)、CDKN1A(cyclin-dependent kinase inhibitor 1A (P21) )、CDKN1B(cyclin-dependent kinase inhibitor 1B)、CDKN1C(cyclin-dependent kinase inhibitor 1C (P57) )、CDKN2a(cyclin dependent kinase inhibitor 2A)、CDKN2b(cyclin dependent kinase inhibitor 2B)、CDKN2D(cyclin dependent kinase inhibitor 2D)、CEACAM1(carcinoembryonic antigen-related cell adhesion molecule 1)、CEACAM3(CEA cell adhesion molecule 3)、CEACAM5(CEA cell adhesion molecule 5)、CEACAM6(CEA cell adhesion molecule 6)、CEACAM8(CEA cell adhesion molecule 8)、Cebpa(CCAAT / enhancer binding protein (C / EBP), alpha)、Cebpb(CCAAT / enhancer binding protein (C / EBP), beta)、Cebpd(CCAAT / enhancer binding protein (C / EBP), delta)、CFD(complement factor D (adipsin) )、Cfh(complement component factor h)、CFI(complement component factor i)、CFL1(cofilin 1,non-muscle)、CHAD(chondroadherin)、Chadl(chondroadherin-like)、CHAT(choline acetyltransferase)、CHEK1(checkpoint kinase 1)、Chek2(checkpoint kinase 2)、CHI3L1(chitinase 3 like 1)、Chrd(chordin)、CHRM2(cholinergic receptor, muscarinic 2, cardiac)、Chrna7(cholinergic receptor, nicotinic, alpha polypeptide 7)、CHRNB2(cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) )、Chst11(carbohydrate sulfotransferase 11)、Chst4(carbohydrate sulfotransferase 4)、CIITA(class II transactivator)、Clcf1(cardiotrophin-like cytokine factor 1)、CLEC11A(Stem cell growth factor)、CLSTN2(calsyntenin 2)、, Clu(clusterin)、Cmklr1(chemokine-like receptor 1)、Cnmd(chondromodulin)、CNTF(Ciliary neurotrophic factor)、COL10A1(collagen, type X, alpha 1)、COL11A1(collagen, type XI, alpha 1)、COL11A2(collagen, type XI, alpha 2)、COL12A1(collagen, type XII, alpha 1)、COL14A1(collagen, type XIV, alpha 1)、COL15A1(collagen, type XV, alpha 1)、COL16A1(collagen, type XVI, alpha 1)、COL18A1(Collagen, type XVIII, alpha 1)、COL1A1(collagen, type I, alpha 1)、COL1A2(collagen, type I, alpha 2)、COL2A1(collagen, type II, alpha 1)、COL3A1(collagen, type III, alpha 1)、COL4A2(collagen, type IV, alpha 2)、COL4A3(Collagen, type IV, alpha 3 (Goodpasture antigen) )、COL4A6(collagen, type IV, alpha 6)、COL5A1(collagen, type V, alpha 1)、COL6A1(collagen, type VI, alpha 1)、COL8A1(collagen, type VIII, alpha 1)、COL9A1(collagen, type IX, alpha 1)、COL9A2(collagen, type IX, alpha 2)、COL9A3(collagen, type IX,alpha 3)、Comp(cartilage oligomeric matrix protein)、Cr2(complement receptor 2)、Creb1(cAMP responsive element binding protein 1)、CRK(v-crk avian sarcoma virus CT10 oncogene homolog)、Crp(C-reactive protein, pentraxin-related)、Crppa(CDP-L-ribitol pyrophosphorylase A)、CryAB(crystallin, alpha B)、CSF1(colony stimulating factor 1 (macrophage)CSF2(colony stimulating factor 2 (granulocyte-macrophage)CSF3(colony stimulating factor 3 (granulocyte)Cst3(Cystatin C)、Ctbp1(C-terminal binding protein 1)、Ctbp2(C-terminal binding protein 2)、CTLA4(cytotoxic T-lymphocyte-associated protein 4)、Ctnnal1(catenin (cadherin associated protein), alpha-like 1)、CTNNB1(catenin (cadherin associated protein), beta 1)、CTNND1(catenin (cadherin associated protein), delta 1)、CTTN(cortactin)、Cx3cl1(chemokine (C-X3-C motif) ligand 1)、, Cx3cr1(chemokine (C-X3-C motif) receptor 1)、CXCL1(chemokine (C-X-C motif) ligand 1)、CXCL10(chemokine (C-X-C motif) ligand 10)、CXCL11(chemokine (C-X-C motif) ligand 11)、CXCL12(chemokine (C-X-C motif) ligand 12)、CXCL13(chemokine (C-X-C motif) ligand 13)、CXCL16(chemokine (C-X-C motif) ligand 16)、CXCL2(chemokine (C-X-C motif) ligand 2)、CXCL3(chemokine (C-X-C motif) ligand 3)、CXCL5(chemokine (C-X-C motif) ligand 5)、CXCL6(Granulocyte chemotactic protein2)、CXCL8(C-X-C motif chemokine ligand 8)、CXCL9(chemokine (C-X-C motif) ligand 9)、CXCR1(chemokine (C-X-C motif) receptor 1)、CXCR2(chemokine (C-X-C motif) receptor 2)、CXCR3(chemokine (C-X-C motif) receptor 3)、CXCR4(chemokine (C-X-C motif) receptor 4)、CXCR5(chemokine (C-X-C motif) receptor 5)、CXCR6(chemokine (C-X-C motif) receptor 6)、Cybb(cytochrome b-245, beta polypeptide)、Cygb(cytoglobin)、Cyp26b1(cytochrome P450, family 26, subfamily b,polypeptide 1)、DAPK3(death-associated protein kinase 3)、DCN(decorin)、Ddit3(DNA-damage inducible transcript 3)、Ddr2(discoidin domain receptor tyrosine kinase 2)、DDX58(DEAD / H box helicase 58)、DIAPH1(diaphanous related formin 1)、Dio2(deiodinase, iodothyronine, type II)、Dkk1(dickkopf WNT signaling pathway inhibitor 1)、Dlk1(delta like non-canonical Notch ligand 1)、Dlx5(distal-less homeobox 5)、DLX6(distal-less homeobox 6)、DPF1(D4, zinc and double PHD fingers family 1)、DPF3(D4, zinc and double PHD fingers, family 3)、DPP4(dipeptidylpeptidase 4)、Dpt(dermatopontin)、DRD2(dopamine receptor D2)、DSCAM(DS cell adhesion molecule)、E2f1(E2F transcription factor 1)、EBI3(Epstein-Barr virus induced gene 3)、EDIL3(EGF-like repeats and discoidin I-like domains 3)、EDN1(endothelin 1)、Efemp1(epidermal growth factor-containing fibulin-like extracellular matrix protein 1)、EFNB2(Ephrin-B2)、EGF(epidermal growth factor)、Egfr(epidermal growth factor receptor)、Egr2(early growth response 2)、Elane(elastase,neutrophil expressed)、Elf3(E74-like factor 3)、ENC1(ectodermal-neural cortex 1)、Eng(endoglin)、Enpp3(ectonucleotide pyrophosphatase / phosphodiesterase 3)、ENTPD1(ectonucleoside triphosphate diphosphohydrolase 1)、EP300(E1A binding protein p300)、EPAS1(endothelial PAS domain protein 1)、Epcam(epithelial cell adhesion molecule)、Epha2(Eph receptor A2)、Ephb2(Eph receptor B2)、Ephb3(Eph receptor B3)、Ephx2(epoxide hydrolase 2, cytoplasmic)、Epo(erythropoietin)、Epyc(epiphycan)、ERBB2("V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro / glioblastoma derived oncogene homolog (avian) ")、EXT1(exostosin glycosyltransferase 1)、EZR(ezrin)、F2(coagulation factor II)、F2r(coagulation factor II (thrombin) receptor)、F2rl1(coagulation factor II (thrombin) receptor-like 1F3(coagulation factor IIIF8(coagulation factor VIIIFabp4(fatty acid binding protein 4, adipocyteFAP(fibroblast activation proteinFAS(Fas (TNF receptor superfamily member 6)Fasl(Fas ligand (TNF superfamily,member 6)FASN(fatty acid synthase)、Fbxo5(F-box protein 5)、Fcer1a(Fc receptor, IgE, high affinity I, alpha polypeptide)、, FCER1G(Fc receptor, IgE, high affinity I, gamma polypeptide)、Fcgr1a(Fc fragment of IgG receptor Ia)、FCGR3B(Fc fragment of IgG receptor IIIa)、FGF1(fibroblast growth factor 1)、FGF10(fibroblast growth factor 10)、FGF19(Fibroblast growth factor 19)、FGF2(fibroblast growth factor 2)、FGF4(Fibroblast growth factor 4)、FGF6(Fibroblast growth factor 6)、FGF7(Fibroblast growth factor 7)、FGF9(Fibroblast growth factor 9 (glia-activating factor) )、FGFR1(fibroblast growth factor receptor 1)、FGFR2(fibroblast growth factor receptor 2)、FGFR3(fibroblast growth factor receptor 3)、FGFR4(fibroblast growth factor receptor 4)、FLRT3(fibronectin leucine rich transmembrane protein 3)、FLT1(FMS-like tyrosine kinase 1)、FLT3LG(FMS-like tyrosine kinase 3 ligan)、FMOD(fibromodulin)、FN1(fibronectin 1)、FOXC2(forkhead box C2)、FOXD1(forkhead box D1)、FOXO1(forkhead box O1)、FOXO3(forkhead box O3)、FOXP3(forkhead box P3)、Fpr1(formyl peptide receptor 1)、Fpr2(formyl peptide receptor 2)、Frzb(frizzled-relatedprotein)、FUT1(Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) )、FUT4(fucosyltransferase 4)、FZD9(Frizzled family receptor 9)、GABRA5(gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5)、GABRB2(gamma-aminobutyric acid (GABA) A receptor, subunit beta 2)、GABRB3(gamma-aminobutyric acid (GABA) A receptor, subunit beta 3)、GAD1(glutamate decarboxylase 1)、GADD45A(growth arrest and DNA-damage-inducible 45 alpha)、Gal(galanin and GMAP prepropeptide)、GALNT5(polypeptide N-acetylgalactosaminyltransferase 5)、GATA2(GATA binding protein 2)、GATA3(GATA binding protein 3)、GATA4(GATA binding protein 4)、GBX2(gastrulation brain homeobox 2)、Gdf10(growth differentiation factor 10)、GDF15(Growth differentiation factor 15)、GDF5(growth differentiation factor 5)、GDF6(growth differentiation factor 6)、GDF7(Growth differentiation factor 7)、GDNF(Glial cell derived neurotrophic factor)、Ghsr(growth hormone secretagogue receptor)、GLB1(galactosidase, beta 1)、Gli1(GLI-Kruppel familymember GLI1)、GNLY(granulysin)、GPC3(glypican3)、 GPC4(glypican4)、GPI(Glucose-6-phosphate isomerase)、Gpm6b(glycoprotein m6b)、Gpr17(G protein-coupled receptor 17)、Gpx4(glutathione peroxidase 4)、Grem1(gremlin 1, DAN family BMP antagonist)、Grn(granulin)、GTF3A(General transcription factor IIIA)、GUSB(glucuronidase, beta)、Gypa(glycophorin A)、GZMB(granzyme B)、H2ac21(H2A clustered histone 21)、HAPLN1(hyaluronan and proteoglycan link protein 1)、HAS1(hyaluronan synthase 1)、HAT1(Histone acetyltransferase 1)、Havcr2(hepatitis A virus cellular receptor 2)、Hbegf(heparin-binding EGF-like growth factor)、Hck(hemopoietic cell kinase)、HDAC1(Histone deacetylase 1)、Hdac5(histone deacetylase 5)、Hdac7(histone deacetylase 7)、Hdac9(histone deacetylase 9)、Hes1(hes family bHLH transcription factor 1)、Hgf(hepatocyte growth factor)、Hif1a(hypoxia inducible factor 1, alpha subunit)、HLA-A(major histocompatibility complex, class I, A)、HLA-B(major histocompatibility complex, class I, B)、HLA-C(major histocompatibility complex, class I,C)、HLA-DMA(major histocompatibility complex, class II, DM alpha)、HLA-DMB(major histocompatibility complex, class II, DM beta)、HLA-DOA(major histocompatibility complex, class II, DO alpha)、HLA-DOB(major histocompatibility complex, class II, DO beta)、HLA-DPA1(major histocompatibility complex, class II, DP alpha 1)、HLA-DPB1(major histocompatibility complex, class II, DP beta 1)、HLA-DQA1(major histocompatibility complex, class II, DQ alpha 1)、HLA-DQA2(major histocompatibility complex, class II, DQ alpha 2)、HLA-DQB1(major histocompatibility complex, class II, DQ beta 1)、HLA-DQB2(major histocompatibility complex, class II, DQ bete 2)、HLA-DRA1(major histocompatibility complex, class II, DR alpha)、HLA-DRB1(major histocompatibility complex, class II, DR bete 1)、HLA-DRB5(major histocompatibility complex, class II, DR beta 5)、HLA-E(major histocompatibility complex, class I, E)、HLA-F(major histocompatibility complex, class I,F)、HLA-F-AS1(HLA-F antisense RNA 1)、HLA-G(major histocompatibility complex, class I, G)、Hmga2(high mobility group AT-hook 2)、Hmox1(heme oxygenase 1)、HNF1A(HNF1 homeobox A)、HPSE(Heparanase)、, Hras(Harvey rat sarcoma virus oncogene)、HSD11B1(hydroxysteroid 11-beta dehydrogenase 1)、HSF1(heat shock factor 1)、HSPA9(heat shock protein 9)、Hspd1(heat shock protein 1 (chaperonin) )、Ibsp(integrin binding sialoprotein)、ICAM1(intercellular adhesion molecule 1)、ICAM2(intercellular cell adhesion molecule)、ICAM5(intercellular adhesion molecule 5, telencephalin)、ICOS(inducible T cell co-stimulator)、ICOSLG(icos ligand)、ID1(inhibitor of DNA binding 1, HLH protein)、ID2(inhibitor of DNA binding 2)、ID4(inhibitor of DNA binding 4)、IDO1(indoleamine 2,3-dioxygenase 1)、IDO2(indoleamine 2,3-dioxygenase 2)、IFI27(interferon,alpha-inducible protein 27)、IFI35(interferon-induced protein 35)、IFI44L(interferon-induced protein 44 like)、IFI6(interferon alpha inducible protein 6)、IFIH1(interferon induced with helicase C domain 1)、IFIT1(interferon-induced protein with tetratricopeptide repeats 1)、IFIT2(interferon-induced protein with tetratricopeptide repeats 2)、IFIT3(interferon-induced protein with tetratricopeptide repeats 3)、IFITM1(interferon induced transmembrane protein 1)、IFITM2(interferon induced transmembrane protein 2)、IFNA1(interferon alpha 1)、IFNA17(interferon alpha 17)、IFNA2(Interferon, alpha 2)、IFNAR1(interferon (alpha and beta) receptor 1)、IFNB1(interferon beta 1,fibroblast)、Ifng(interferon gamma)、Ifngr1(interferon gamma receptor 1)、Ifngr2(interferon gamma receptor 2)、IGF1(insulin-like growth factor 1)、IGF1R(insulin-like growth factor I receptor)、IGF2(insulin-like growth factor 2)、IGF2R(insulin-like growth factor 2 receptor)、IGFBP1(insulin-like growth factor binding protein 1)、IGFBP2(insulin-like growth factor binding protein 2)、IGFBP3(insulin-like growth factor binding protein 3)、IGFBP4(insulin-like growth factor binding protein 4)、IGFBP5(insulin-like growth factor binding protein 5)、IGFBP6(insulin-like growth factor binding protein 6)、IGFBP7(insulin-like growth factor binding protein 7)、Igsf11(immunoglobulin superfamily, member 11)、Ihh(Indian hedgehog)、IL10(interleukin 10)、IL10RA(interleukin 10 receptor,alpha)、IL11(Interleukin 11)、IL12A(interleukin 12a)、IL12B(interleukin 12b)、IL13(interleukin 13)、IL13RA2(interleukin 13 receptor subunit alpha 2)、IL15(interleukin 15)、IL16(interleukin 16)、IL17a(interleukin 17A)、IL17b(interleukin 17B)、IL17c(interleukin 17C)、IL17d(interleukin 17D)、, IL17f(interleukin 17F)、IL17ra(interleukin 17 receptor A)、IL17rb(interleukin 17 receptor B)、IL17rc(interleukin 17 receptor C)、IL17re(interleukin 17 receptor E)、IL18(interleukin 18)、IL18r1(interleukin 18 receptor 1)、IL18rap(interleukin 18 receptor accessory protein)、IL1a(interleukin 1 alpha)、IL1b(interleukin 1 beta)、IL1f10(interleukin 1 family, member 10)、IL1r1(interleukin 1 receptor, type I)、IL1r2(interleukin 1 receptor, type II)、IL1rap(interleukin 1 receptor accessory protein)、IL1rl1(interleukin 1 receptor-like 1)、IL1rl2(interleukin 1 receptor-like 2)、IL1rn(interleukin 1 receptor antagonist)、IL2(interleukin 2)、IL21(interleukin 21)、IL22(interleukin 22)、IL22ra2(interleukin 22 receptor, alpha 2)、IL23a(interleukin 23, alpha subunit p19)、IL23r(interleukin 23 receptor)、IL24(Interleukin 24)、IL25(interleukin 25)、IL27(interleukin 27)、IL2ra(interleukin 2 receptor, alpha chain)、IL2RB(interleukin 2 receptor, beta chain)、IL2RG(interleukin 2 receptor,gamma chain)、IL3(interleukin 3)、IL31ra(interleukin 31 receptor A)、IL33(interleukin 33)、IL34(interleukin 34)、IL3RA(interleukin 3 receptor, alpha chain)、IL4(interleukin 4)、IL5(interleukin 5)、IL5ra(interleukin 5 receptor, alpha)、IL6(interleukin 6)、IL6R(interleukin 6 receptor, alpha)、IL6ST(interleukin 6 signal transducer)、IL7(interleukin 7)、IL7R(interleukin 7 receptor)、IL9(interleukin 9)、ILK(integrin linked kinase)、INHBA(Inhibin, beta A)、INHBE(inhibin subunit beta E)、INS(Insulin)、INSC(INSC spindle orientation adaptor protein)、INSR(insulin receptor)、Irak2(interleukin-1 receptor-associated kinase 2)、IRF1(interferon regulatory factor 1)、IRF3(interferon regulatory factor 3)、IRF4(interferon regulatory factor 4)、IRF7(interferon regulatory factor 7)、IRF9(interferon regulatory factor 9)、IRS1(insulin receptor substrate 1)、IRS2(insulin receptor substrate 2)、ITGA1(integrin a1)、ITGA10(integrin, alpha 10)、ITGA11(integrin alpha 11)、ITGA2(integrin alpha 2)、ITGA2b(integrin alpha 2b)、, ITGA3(integrin a3)、ITGA4(integrin alpha 4)、ITGA5(integrin alpha 5)、ITGA6(integrin alpha 6)、ITGA7(integrin alpha 7)、ITGA8(integrin alpha 8)、ITGA9(integrin alpha 9)、ITGAD(integrin, alpha D)、ITGAE(integrin alpha E, epithelial-associated)、ITGAL(integrin alpha L)、ITGAM(integrin alpha M)、ITGAV(integrin alpha V)、ITGAX(integrin alpha X)、ITGB1(integrin beta 1 (fibronectin receptor beta) )、ITGB2(integrin beta 2)、ITGB3(integrin beta 3)、ITGB4(integrin beta 4)、ITGB5(integrin b5)、ITGB6(integrin beta 6)、ITGB7(integrin beta 7)、ITGB8(integrin subunit beta 8)、Itih4(inter alpha-trypsin inhibitor,heavy chain 4)、JAG1(jagged 1)、JAG2(jagged 2)、JAK1(Janus kinase 1)、JAK2(Janus kinase 2)、JAKMIP3(janus kinase and microtubule interacting protein 3)、JCAD(junctional cadherin 5 associated)、JUN(jun proto-oncogene)、KAT2B(K(lysine) acetyltransferase 2B)、Kdr(kinase insert domain protein receptor)、KIF20B(kinesin family member 20B)、KIRREL3(kirre like nephrin family adhesion molecule 3)、Kit(KIT proto-oncogene receptor tyrosine kinase)、KITLG(kit ligand)、KLF15(Kruppel-like factor 15)、KLF2(Kruppel-like factor 2 (lung) )、KLF3(Kruppel-like factor 3 (basic) )、KLF4(Kruppel-like factor 4 (gut) )、KLF5(Kruppel-like factor 5)、Klkb1(kallikrein B, plasma 1)、KLRG1(killer cell lectin-like receptor subfamily G, member 1)、Kng1(kininogen 1)、KRT1(keratin 1)、KRT18(keratin 18)、KRT8(Keratin 8)、L1CAM(L1 cell adhesion molecule)、LAMA1(laminin, alpha 1)、LAMA2(laminin, alpha 2)、LAMA3(laminin, alpha 3)、LAMA4(laminin,alpha 4)、LAMB1(laminin B1)、Lamp1(lysosomal-associated membrane protein 1)、Lamp2(lysosomal-associated membrane protein 2)、Lamtor2(late endosomal / lysosomal adaptor, MAPK and MTOR activator 2)、Lbp(lipopolysaccharide binding protein)、Lep(leptin)、Lgals1(lectin, galactose binding, soluble 1)、LGALS3(lectin, galactose binding, soluble 3)、Lgals9(lectin, galactose binding, soluble 9)、LIF(leukemia inhibitory factor)、LIMK1(LIM-domain containing, protein kinase)、LIPE(lipase, hormone sensitive)、Lmna(lamin A)、LMNB1(lamin B1)、LMNB2(lamin B2)、LOX(lysyl oxidase)、Lpl(lipoprotein lipase)、Lrp1(low density lipoprotein receptor-related protein 1)、Lrp5(low density lipoprotein receptor-related protein 5)、LRRTM2(leucine rich repeat transmembrane neuronal 2)、LSAMP(limbic system-associated membrane protein)、LSM5(LSM5 homolog,U6 small nuclear RNA and mRNA degradation associated)、Lta(lymphotoxin A)、Ltbp1(latent transforming growth factor beta binding protein 1)、Ly86(lymphocyte antigen 86)、Ly96(lymphocyte antigen 96)、Lyn(LYN proto-oncogene, Src family tyrosine kinase)、LYZ(lysozyme 1)、MAFK(v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) )、MAGEA1(melanoma antigen, family A, 1)、, MAGEA10(melanoma antigen family A, 10)、MAGEA12(MAGE family member A12)、MAGEA3(melanoma antigen, family A, 3)、MAGEA4(melanoma antigen, family A, 4)、MAP2(microtubule-associated protein 2)、MAP2K1(mitogen-activated protein kinase kinase 1)、MAPK1(mitogen-activated protein kinase 1)、MAPK14(mitogen-activated protein kinase 14)、MAPK3(mitogen-activated protein kinase 3)、MAPK8(mitogen-activated protein kinase 8)、MAPKAPK2(MAP kinase-activated protein kinase 2)、Matn1(matrilin 1, cartilage matrix protein)、Matn3(matrilin 3)、Matn4(matrilin 4)、MBP(myelin basic protein)、MCAM(melanoma cell adhesion molecule)、Mdk(midkine)、MEF2C(myocyte enhancer factor 2C)、Mefv(Mediterranean fever)、MEG3(maternally expressed 3)、MET(met proto-oncogene)、Mgll(monoglyceride lipase)、MICA(MHC class I polypeptide-related sequence A)、MICB(MHC class I polypeptide-related sequence B)、Mif(macrophage migration inhibitory factor)、Mir34a(microRNA 34a)、Mki67(antigen identified by monoclonal antibody Ki 67)、Mme(membrane metalloendopeptidase)、MMP1(matrix metallopeptidase 1)、MMP12(matrix metallopeptidase 12)、MMP13(matrix metallopeptidase 13)、MMP14(matrix metallopeptidase 14 (membrane-inserted) )、MMP15(matrix metallopeptidase 15)、MMP16(matrix metallopeptidase 16)、MMP2(matrix metallopeptidase 2)、MMP25(matrix metallopeptidase 25)、MMP3(matrix metallopeptidase 3)、MMP7(matrix metallopeptidase 7)、MMP8(matrix metallopeptidase 8)、MMP9(matrix metallopeptidase 9)、Morc3(microrchidia 3)、MPO(myeloperoxidase)、Mrap(melanocortin 2 receptor accessory protein)、MST1(macrophage stimulating 1)、MSTN(Myostatin)、Msx1(msh homeobox 1)、Msx2(msh homeobox 2)、MX1(MX dynamin-like GTPase 1)、Myc(MYC proto-oncogene, bHLH transcription factor)、Myd88(myeloid differentiation primary response gene 88)、MYL9(myosin, light polypeptide 9, regulatory)、MYLK(myosin, light polypeptide kinase)、Nampt(nicotinamide phosphoribosyltransferase)、Nanog(Nanog homeobox)、NCAM(neural cell adhesion molecule 1)、NCOA2(nuclear receptor coactivator 2)、 Ncor2(nuclear receptor co-repressor 2)、NCR3LG1(natural killer cell cytotoxicity receptor 3 ligand 1)、NDP(Norrie disease (pseudoglioma) (human) )、Ndst1(N-deacetylase / N-sulfotransferase (heparan glucosaminyl) 1)、NECTIN2(nectin cell adhesion molecule 2)、NES(Nestin)、NETO1(neuropilin (NRP) and tolloid (TLL)-like 1)、Neurog1(neurogenin 1)、NF1(neurofibromin 1)、Nfe2l1(nuclear factor, erythroid derived 2,-like 1)、Nfe2l2(nuclear factor, erythroid derived 2, like 2)、Nfkb1(nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105)、Nfkbia(nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha)、Nfkbid(nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta)、NGF(Nerve growth factor (beta polypeptide) )、NGFR(nerve growth factor receptor (TNFR superfamily, member 16) )、Ninj1(ninjurin 1)、Nlrp12(NLR family, pyrin domain containing 12)、Nlrp3(NLR family,pyrin domain containing 3)、NODAL(Nodal homolog (mouse))、Nog(noggin)、NOS1(nitric oxide synthase 1, inducible)、NOS2(nitric oxide synthase 2, inducible)、NOS3(Nitric oxide synthase 3 (endothelial cell) )、NOTCH1(Notch 1)、Nox4(NADPH oxidase 4)、NR0B2(nuclear receptor subfamily 0, group B, member 2)、Nr1d1(nuclear receptor subfamily 1, group D, member 1)、NR1H3(nuclear receptor subfamily 1, group H, member 3)、NR3C1(nuclear receptor subfamily 3, group C, member 1)、NRF1(nuclear respiratory factor 1)、NRG1(Neuregulin 1)、NRGN(neurogranin)、NRP1(neuropilin 1)、NRP2(Neuropilin 2)、NT5E(5' nucleotidase, ecto)、NTF3(Neurotrophin 3)、NTF4(Neurotrophin 4)、NTN4(netrin 4)、Ntrk1(neurotrophic tyrosine kinase, receptor, type 1)、NUDT6(Nudix (nucleoside diphosphate linked moiety X)-type motif 6)、Ogn(osteoglycin)、Olr1(oxidized low density lipoprotein (lectin-like) receptor 1)、Orm1(orosomucoid 1)、Orm2(orosomucoid 2)、Osm(oncostatin M)、Otor(otoraplin)、OXTR(oxytocin receptor)、P2rx7(purinergic receptor P2X,ligand-gated ion channel, 7)、Pak1(p21 (RAC1) activated kinase 1)、PAK4(p21 (RAC1) activated kinase 4)、, PAM(peptidylglycine alpha-amidating monooxygenase)、Parp4(poly (ADP-ribose) polymerase family, member 4)、PCM1(pericentriolar material 1)、PCNA(proliferating cell nuclear antigen)、PDCD1(programmed cell death 1)、Pdcd1lg2(programmed cell death 1 ligand 2)、PDGFA(platelet derived growth factor, alpha)、PDGFb(platelet derived growth factor, B polypeptide)、PDGFRA(platelet derived growth factor receptor, alpha polypeptide)、PDGFRB(platelet derived growth factor receptor, beta polypeptide)、PECAM1(platelet / endothelial cell adhesion molecule 1)、PENK(preproenkephalin)、PF4(Platelet factor 4)、PGF(Placental growth factor)、Pglyrp1(peptidoglycan recognition protein 1)、Phex(phosphate regulating endopeptidase homolog, X-linked)、PHOX2A(paired-like homeobox 2a)、PIGF(phosphatidylinositol glycan anchor biosynthesis, class F)、PIGS(Phosphatidylinositol glycan anchor biosynthesis, class S)、PIK3CA(phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)、Pik3cd(phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta)、Pik3cg(phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)、Pknox1(Pbx / knotted 1 homeobox)、Pla2g2d(phospholipase A2, group IID)、Pla2g5(phospholipase A2, group V)、Pla2g7(phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) )、PLAT(plasminogen activator, tissue type)、PLAU(plasminogen activator, urokinase)、PLAUR(plasminogen activator, urokinase receptor)、PLCG1(phospholipase C, gamma 1)、PLD1(phospholipase D1)、PLG(plasminogen)、Plin1(perilipin 1)、Pml(PML nuclear body scaffold)、POT1(protection of telomeres 1A)、Pou4f1(POU domain, class 4, transcription factor 1)、POU5F1(POU class 5 homeobox 1)、PPARA(peroxisome proliferator activated receptor alpha)、Ppard(peroxisome proliferator activator receptor delta)、Pparg(peroxisome proliferator activated receptor gamma)、Ppargc1a(peroxisome proliferative activated receptor, gamma, coactivator 1 alpha)、PPARGC1B(peroxisome proliferative activated receptor, gamma,coactivator 1 beta)、Ppbp(pro-platelet basic protein)、Prdm16(PR domain containing 16)、PRDX4(peroxiredoxin 4)、PRF1(perforin 1 (pore forming protein)Prg4(proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)Prkca(protein kinase C, alpha)、Prkcd(protein kinase C, delta)、Prkcz(protein kinase C, zeta)、PRL(Prolactin)、PROCR(protein C receptor, endothelial)、PROK1(Prokineticin 1)、PROK2(Prokineticin 2)、PROM1(Prominin 1)、Pspn(Persefin)、Ptafr(platelet-activating factor receptor)、, PTEN(phosphatase and tensin homolog)、PTGES(prostaglandin E synthase)、Ptgfr(prostaglandin F receptor)、Ptgis(prostaglandin I2 (prostacyclin) synthase)、Ptgs1(prostaglandin-endoperoxide synthase 1)、Ptgs2(prostaglandin-endoperoxide synthase 2)、Pthlh(parathyroid hormone-like peptide)、Ptk2(PTK2 protein tyrosine kinase 2)、Ptn(pleiotrophin)、PTPRC(protein tyrosine phosphatase, receptor type, C)、PTX3(pentraxin related gene)、Pvr(poliovirus receptor)、pxn(paxillin)、Pycard(PYD and CARD domain containing)、RAB8A(RAB8A, member RAS oncogene family)、RAC1(Rac family small GTPase 1)、Rara(retinoic acid receptor, alpha)、RASA1(RAS p21 protein activator 1)、RB1(RB transcriptional corepressor 1)、Rbl1(RB transcriptional corepressor like 1)、Reg3a(regenerating islet-derived 3 alpha)、Reg3g(regenerating islet-derived 3 gamma)、Rel(reticuloendotheliosis oncogene)、Rela(v-rel reticuloendotheliosis viral oncogene homolog A (avian) )、Retn(resistin)、RHO(rhodopsin)、Rhoa(ras homolog family member A)、RHOB(ras homolog familymember B)、RND3(Rho family GTPase 3)、robo1(roundabout guidance receptor 1)、ROBO3(roundabout guidance receptor 3)、Rock1(Rho associated coiled-coil containing protein kinase 1)、Rock2(Rho associated coiled-coil containing protein kinase 2)、Ror2(receptor tyrosine kinase-like orphan receptor 2)、RORC(RAR-related orphan receptor gamma)、ROS1(Ros1 proto-oncogene)、Rpl13a(ribosomal protein L13A)、Runx1t1(RUNX1 translocation partner 1)、Runx2(runt related transcription factor 2)、RXRA(retinoid X receptor alpha)、S100a8(S100 calcium binding protein A8 (calgranulin A) )、S100a9(S100 calcium binding protein A9 (calgranulin B) )、S1P3(sphingosine-1-phosphate receptor 3)、S1PR1(Sphingosine-1-phosphate receptor 1)、Saa4(serum amyloid A 4)、Scgb1a1(secretoglobin, family 1A, member 1 (uteroglobin) )、SCN1B(sodium channel, voltage-gated, type I, beta)、SCN3B(sodium channel, voltage-gated, type III, beta)、SDC2(syndecan2)、SDC3(syndecan3)、Sele(selectin, endothelial cell)、SELL(selectin, lymphocyte)、Selp(selectin,platelet)、selplg(selectin, platelet (p-selectin) ligand)、SEMA3A(sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A)、Sema7a(sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A)、SERPINA1(serpin family A member 1)、SERPINB5(serpin family B member 5)、SERPINC1(Serpin peptidase inhibitor, clade C (antithrombin), member 1)、Serpine1(serine (or cysteine) peptidase inhibitor, clade E, member 1)、SERPINF1("Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1")、 Serpinf2(serine (or cysteine) peptidase inhibitor, clade F, member 2)、SERPINH1(serpin family H member 1)、Sfrp1(secreted frizzled-related protein 1)、SFRP5(secreted frizzled-related sequence protein 5)、SH2B2(SH2B adaptor protein 2)、SH3PXD2A(SH3 and PX domains 2A)、SHB(src homology 2 domain-containing transforming protein B)、SHBG(sex hormone binding globulin)、SHH(sonic hedgehog)、Shox2(short stature homeobox 2)、Sigirr(single immunoglobulin and toll-interleukin 1 receptor (TIR) domain)、SIRT1(sirtuin 1)、SIRT2(sirtuin 2)、SIRT3(sirtuin 3)、SIRT6(sirtuin 6)、SLC17A5(Solute carrier family 17 (anion / sugar transporter), member 5)、SLC1A3(solute carrier family 1 (glial high affinity glutamate transporter), member 3)、Slc2a4(solute carrier family 2 (facilitated glucose transporter), member 4)、Slc3a2(solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2)、Slc7a5(solute carrier family 7 member 5)、SLC9A6(solute carrier family 9 (sodium / hydrogen exchanger),member 6)、SLIT3(slit guidance ligand 3)、Slitrk6(SLIT and NTRK-like family, member 6)、SMAD1(SMAD family member 1)、SMAD2(SMAD family member 2)、SMAD3(SMAD family member 3)、SMAD4(SMAD family member 4)、SMAD5(SMAD family member 5)、SMAD6(SMAD family member 6)、SMAD7(SMAD family member 7)、Smurf1(SMAD specific E3 ubiquitin protein ligase 1)、SMURF2(SMAD specific E3 ubiquitin protein ligase 2)、SNAI1(snail family transcriptional repressor 1)、Snai2(snail family zinc finger 2)、SNCA(synuclein, alpha)、Snx19(sorting nexin 19)、Socs3(suppressor of cytokine signaling 3)、Socs5(suppressor of cytokine signaling 5)、Sod1(superoxide dismutase 1,soluble)、Sort1(sortilin 1)、Sost(sclerostin)、SOX2(SRY (sex determining region Y)-box 2)、SOX4(SRY (sex determining region Y)-box 4)、SOX5(SRY (sex determining region Y)-box 5)、SOX6(SRY (sex determining region Y)-box 6)、SOX9(SRY (sex determining region Y)-box 9)、SP1(Sp1 transcription factor)、Sp7(Sp7 transcription factor 7)、Sparc(secreted acidic cysteine rich glycoprotein)、SPG7(SPG7, paraplegin matrix AAA peptidase subunit)、SPHK1(Sphingosine kinase 1)、Spn(sialophorin)、SPON2(spondin 2, extracellular matrix protein)、Spp1(secreted phosphoprotein 1)、SPTBN5(spectrin beta, non-erythrocytic 5)、SRC(Rous sarcoma oncogene)、Srebf1(sterol regulatory element binding transcription factor 1)、ST3GAL2(ST3 beta-galactoside alpha-2,3-sialyltransferase 2)、ST6GAL1(beta galactoside alpha 2,6 sialyltransferase 1)、, Stab1(stabilin 1)、STAT1(signal transducer and activator of transcription 1)、STAT3(signal transducer and activator of transcription 3)、STAT4(signal transducer and activator of transcription 4)、STAT5a(signal transducer and activator of transcription 5A)、STAT5b(signal transducer and activator of transcription 5B)、STAT6(signal transducer and activator of transcription 6)、STC1(stanniocalcin 1)、STMN3(stathmin-like 3)、HSPA8(heat shock protein 8)、SVIL(supervillin)、Syk(spleen tyrosine kinase)、SYNGR1(synaptogyrin 1)、TAZ(tafazzin)、Tbx2(T-box 2)、TBX21(T-box 21)、Tbx3(T-box 3)、TBX5(T-box 5)、Tcf7l2(transcription factor 7 like 2, T cell specific, HMG box)、Tek(TEK receptor tyrosine kinase)、TENM2(teneurin transmembrane protein 2)、TERF1(telomeric repeat binding factor 1)、Terf2(telomeric repeat binding factor 2)、Tert(telomerase reverse transcriptase)、TFAM(transcription factor A, mitochondrial)、TFRC(transferrin receptor)、TGFA(Transforming growth factor, alpha)、Tgfb1(transforming growth factor,beta 1)、Tgfb2(transforming growth factor, beta 2)、TGFb3(transforming growth factor, beta 3)、TGFBR1(transforming growth factor, beta receptor I)、TGFBR2(transforming growth factor, beta receptor II)、TGFBR3(transforming growth factor, beta receptor III)、TGIF1(TGFB induced factor homeobox 1)、TGM2(transglutaminase 2, C polypeptide)、Thbs1(thrombospondin 1)、THBS2(thrombospondin 2)、THPO(Thrombopoietin)、THY1(Thy-1 cell surface antigen)、TIE1(Tyrosine kinase with immunoglobulin-like and EGF-like domains 1)、TIGIT(T cell immunoreceptor with Ig and ITIM domains)、TIMP1(tissue inhibitor of metalloproteinase 1)、TIMP2(tissue inhibitor of metalloproteinase 2)、TIMP3(tissue inhibitor of metalloproteinase 3)、TIMP4(tissue inhibitor of metalloproteinase 4)、Tirap(toll-interleukin 1 receptor (TIR) domain-containing adaptor protein)、Tlr1(toll-like receptor 1)、, Tlr2(toll-like receptor 2)、Tlr3(toll-like receptor 3)、Tlr4(toll-like receptor 4)、Tlr5(toll-like receptor 5)、Tlr6(toll-like receptor 6)、Tlr7(toll-like receptor 7)、Tlr8(toll-like receptor 8)、Tlr9(toll-like receptor 9)、TMEM33(transmembrane protein 33)、TMSB15A(thymosin beta 15a)、TNC(tenascin C)、Tnf(tumor necrosis factor)、Tnfaip3(tumor necrosis factor, alpha-induced protein 3)、Tnfaip6(tumor necrosis factor alpha induced protein 6)、TNFAIP8(tumor necrosis factor, alpha-induced protein 8)、TNFRSF10C(TNF receptor superfamily member 10c)、TNFRSF10D(TNF receptor superfamily member 10c)、Tnfrsf11b(tumor necrosis factor receptor superfamily, member 11b)、Tnfrsf14(tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) )、TNFRSF17(tumor necrosis factor receptor superfamily, member 17)、TNFRSF18(tumor necrosis factor receptor superfamily, member 18)、Tnfrsf1a(tumor necrosis factor receptor superfamily, member 1a)、Tnfrsf1b(tumor necrosis factor receptor superfamily,member 1b)、Tnfrsf4(tumor necrosis factor receptor superfamily, member 4)、TNFRSF9(tumor necrosis factor receptor superfamily, member 9)、Tnfsf10(tumor necrosis factor (ligand) superfamily, member 10)、Tnfsf11(tumor necrosis factor (ligand) superfamily, member 11)、TNFSF13(tumor necrosis factor (ligand) superfamily, member 13)、TNFSF13B(tumor necrosis factor (ligand) superfamily, member 13b)、Tnfsf14(tumor necrosis factor (ligand) superfamily, member 14)、Tnfsf15(tumor necrosis factor (ligand) superfamily, member 15)、Tnfsf18(tumor necrosis factor (ligand) superfamily, member 18)、Tnfsf4(tumor necrosis factor (ligand) superfamily, member 4)、Tnfsf8(tumor necrosis factor (ligand) superfamily, member 8)、Tnfsf9(tumor necrosis factor (ligand) superfamily,member 9)、Tollip(toll interacting protein)、TRA(T cell receptor alpha locus)、Traf6(TNF receptor-associated factor 6)、TRB(T cell receptor beta locus)、Trem1(triggering receptor expressed on myeloid cells 1)、Trem2(triggering receptor expressed on myeloid cells 2)、TRIM3(tripartite motif-containing 3)、Trp53(transformation related protein 53)、Trp53bp1(transformation related protein 53 binding protein 1)、Trpv1(transient receptor potential cation channel, subfamily V, member 1)、Tsc2(TSC complex subunit 2)、, TSC22D3(TSC22 domain family, member 3)、Tslp(thymic stromal lymphopoietin)、Twist1(twist basic helix-loop-helix transcription factor 1)、Twist2(twist basic helix-loop-helix transcription factor 2)、TXNIP(thioredoxin interacting protein)、TYMP(Thymidine phosphorylase)、Ucp1(uncoupling protein 1 (mitochondrial, proton carrier)Uts2(urotensin 2)、VASH1(vasohibin 1)、VASP(vasodilator-stimulated phosphoprotein)、VCAM1(vascular cell adhesion molecule 1)、Vcan(versican)、vcl(vinculin)、VDR(vitamin D (1,25-dihydroxyvitamin D3) receptor)、Vegfa(vascular endothelial growth factor A)、VEGFB(Vascular endothelial growth factor B)、VEGFC(vascular endothelial growth factor C)、VEGFD(vascular endothelial growth factor D)、VIM(Vimentin)、VPS13A(vacuolar protein sorting 13A)、VPS13C(vacuolar protein sorting 13C)、Vsir(V-set immunoregulatory receptor)、Vtcn1(V-set domain containing T cell activation inhibitor 1)、VTN(vitronectin)、VWA5A(von Willebrand factor A domain containing 5A)、VWF(Von Willebrand factor)、WEE1(WEE 1 homolog 1 (S. pombe)WIPF1(WAS / WASL interacting protein family, member 1)、Wnt1(wingless-type MMTV integration site family, member 1)、Wnt10b(wingless-type MMTV integration site family, member 10B)、Wnt3a(wingless-type MMTV integration site family, member 3A)、Wnt5a(wingless-type MMTV integration site family, member 5A)、Wnt5b(wingless-type MMTV integration site family,member 5B)、Wrn(Werner syndrome RecQ like helicase)、Xcl1(chemokine (C motif) ligand 1)、Xcr1(chemokine (C motif) receptor 1)、Ywhaz(tyrosine 3-monooxygenase / tryptophan 5-monooxygenase activation protein, zeta polypeptide)、Zfp36(zinc finger protein 36)、ZFP42(Zinc finger protein 42 homolog (mouse) )、Zhx3(zinc fingers and homeoboxes 3)、Zmpste24(zinc metallopeptidase, STE24)、ZNF25(zinc finger protein 25)、ACTC1(actin, alpha, cardiac muscle 1)、AFF3(AF4 / FMR2 family, member 3)、AGMO(alkylglycerol monooxygenase)、AHNAK2(AHNAK nucleoprotein 2)、AK4(adenylate kinase 4)、AKR1C1(aldo-keto reductase family 1, member C1)、ANKRD1(ankyrin repeat domain 1 (cardiac muscle) )、ANXA10(annexin A10)、B3GALT2(UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase 2)、BST2(bone marrow stromal cell antigen 2)、C1orf198(chromosome 1 open reading frame 198)、C2orf88(chromosome 2 open reading frame 88)、CCND2(cyclin D2)、CEMIP(cell migration inducing protein, hyaluronan binding)、, CHAC1(ChaC glutathione-specific gamma-glutamylcyclotransferase 1)、CHRNA1(cholinergic receptor, nicotinic alpha 1)、CLDN1(claudin 1)、CLDN11(claudin 11)、CNIH3(cornichon family AMPA receptor auxiliary protein 3)、CNN1(calponin 1, basic, smooth muscle)、CSGALNACT1(chondroitin sulfate N-acetylgalactosaminyltransferase 1)、CTSS(cathepsin S)、CYP1B1(cytochrome P450, family 1, subfamily B, polypeptide 1)、DAPK1(death-associated protein kinase 1)、DDIT4(DNA damage inducible transcript 4)、DIRAS3(DIRAS family, GTP-binding RAS-like 3)、EBF2(early B-cell factor 2)、ELN(elastin)、ESM1(endothelial cell-specific molecule 1)、ETV1(ets variant 1)、FABP3(fatty acid binding protein 3, muscle and heart)、FHL1(four and a half LIM domains 1)、FLG(filaggrin)、FOSB(FBJ murine osteosarcoma viral oncogene homolog B)、GBP4(guanylate binding protein 4)、GBP5(guanylate binding protein 5)、GFRA1(GDNF family receptor alpha 1)、HAS2(hyaluronan synthase 2)、HHIP(hedgehog interacting protein)、H2AC8(histone cluster 1,H2ae)、H2ac7(histone cluster 1, H2ad)、H3C4(histone cluster 1, H3d)、H3C8(histone cluster 1, H3g)、HSPB6(heat shock protein, alpha-crystallin-related, B6)、IL18BP(interleukin 18 binding protein)、IL32(interleukin 32)、Acod1(immunoresponsive 1 homolog (mouse) )、KCTD16(potassium channel tetramerization domain containing 16)、KLF10(Kruppel-like factor 10)、KRT34(keratin 34, type I)、KRTAP1-1(keratin associated protein 1-1)、KRTAP1-5(keratin associated protein 1-5)、LMOD1(leiomodin 1 (smooth muscle) )、LRIG3(leucine-rich repeats and immunoglobulin-like domains 3)、LRRC15(leucine rich repeat containing 15)、LRRC17(leucine rich repeat containing 17)、LYPD6B(LY6 / PLAUR domain containing 6B)、MALL(mal, T-cell differentiation protein-like)、MFAP4(microfibrillar associated protein 4)、MKX(mohawk homeobox)、MYCT1(myc target 1)、NEFM(neurofilament, medium polypeptide)、NFASC(neurofascin)、NFATC2(nuclear factor of activated T-cells, cytoplasmic,calcineurin-dependent 2)、NTSR1(neurotensin receptor 1 (high affinity) )、OAS1(2-5-oligoadenylate synthetase 1)、PHLDA1(pleckstrin homology-like domain, family A, member 1)、PITX2(paired-like homeodomain 2)、PREX1(phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1)、PSAT1(phosphoserine aminotransferase 1)、PSG9(pregnancy specific beta-1-glycoprotein 9)、RAB27B(RAB27B, member RAS oncogene family)、, RCAN2 (regulator of calcineurin 2), RDH5 (retinol dehydrogenase 5 (11-cis / 9-cis)), RGCC (regulator of cell cycle), RIMS1 (regulating synaptic membrane exocytosis 1), RORA (RAR-related orphan receptor A), RPL12 (Zhang2013 ALT_ACCEPTOR, ALT_DONOR, coding, INTERNAL, intronic best transcript NM_000976), RSAD2 (radical S-adenosyl methionine domain containing 2), SCRG1 (stimulator of chondrogenesis 1), SERPINB2 (serpin peptidase inhibitor, clade B (ovalbumin), member 2), SLAMF8 (SLAM family member 8), SLC14A1 (solute carrier family 14 (urea transporter), member 1 (Kidd blood group)), SLC38A1 (solute carrier family 38, member 1), SYT1 (synaptotagmin I), TFPI2 (tissue factor pathway inhibitor 2), THBS4 (thrombospondin 4), TINAGL1 (tubulointerstitial nephritis antigen-like 1), TMEM130 (transmembrane protein 130), TNMD (tenomodulin), UBD (ubiquitin D), VIT (vitrin), XG (Xg blood group; Xg pseudogene, Y-linked 2), GAPDH (glyceraldehyde-3-phosphate dehydrogenase), CMRF-56

[0111] (2) Deletion of specific genes Of the genes selected in (1) above, CMRF-56 was removed because it is a dendritic cell marker. When ordering primers from Illumina, there were 18 genes that were not sold by Illumina, so these were removed. These 18 genes are as follows: HLA-DRB5, NTF4, UTS2, MIF, CD24, CD70, IL17D, C2ORF88, HLA-DQB1, CEMIP, CD165, TRA, TRB, XCL1, ACOD1, CCR10, CXCR3, MIR34A

[0112] (3) Preparation of two types of primer sets The following two types of primer sets were prepared. Primer set containing highly expressed genes Primer set excluding highly expressed genes

[0113] Of the 1,181 genes excluding CMRF-56 and the 18 mentioned above, 38 genes were considered for replacement with other genes due to their high expression. Concerned that highly expressed genes may account for a large proportion of the read count if they are included in the primer set, two primer sets were created: one that does not include highly expressed genes (1,143 genes) and one that includes highly expressed genes (1,181 genes). The 38 highly expressed genes are as follows:

[0114] ACTB, Ahsg, B2M, Bsg, C3, Calr, CD63, CFL1, Clu, COL6A1 CTNNB1, FASN, FN1, GPC3, GPI, HLA-A, HLA-B, Hspd1, IGFBP3, IGFBP4 IGFBP5, KRT18, KRT8, Lgals1, Mki67, Nfe2l1, SERPINA1, SERPINH1, Slc7a5, Sparc HSPA8, TFRC, THBS2, TIMP2, TNC, VIM, Ywhaz, GAPDH

[0115] Example 8: Measurement of gene expression (1) Reverse transcription Ampliseq cDNA Synthesis for Illumina (Illumina, 20022654) was used. Following the manufacturer's protocol, the AmpliSeq cDNA Reaction Mix, AmpliSeq RT Enzymer Mix, and prepared mRNA were mixed. This was then placed in a thermal cycler and the RT reaction was carried out (one cycle at 42°C for 30 minutes, followed by one cycle at 85°C for 5 minutes, and then maintained at 10°C for completion).

[0116] (2) PCR reaction (first round) AmpliSeq for Illumina Custom RNA Panel (Illumina, 20020496) and AmpliSeq for Illumina Library PLUS (Illumina, 20019102) were used. Following the manufacturer's protocol, AmpliSeq HiFi Mix, AmpliSeq Custom RNA Panel, and cDNA were mixed and placed in a thermal cycler for PCR (1 cycle of 99°C for 2 minutes, followed by 15 cycles of 99°C for 15 seconds, then 60°C for 8 minutes, followed by a 10°C hold to complete the reaction).

[0117] (3) Partial digestion of the amplicon AmpliSeq for Illumina Library PLUS (Illumina, 20019102) was used. FuPa Reagent was added to the PCR reaction mixture, mixed, and then placed in a thermal cycler for reaction (1 cycle each of 50°C for 10 minutes, 55°C for 10 minutes, and 62°C for 20 minutes, followed by a 10°C hold).

[0118] (4) Index adapter ligation AmpliSeq for Illumina Library PLUS (Illumina, 20019102) and AmpliSeq for Illumina CD Indexes Set A (Illumina, 20029105) were used. After the previous step, Switch Solution, AmpliSeq CD indexes, and DNA Ligase were added immediately in that order. After mixing, the mixture was placed in a thermal cycler and the ligation reaction was carried out (one cycle each of 22°C for 30 minutes, 68°C for 5 minutes, and 72°C for 5 minutes, followed by a 10°C hold to complete the reaction).

[0119] (5) Refining AMPure XP 450 mL Kit (BECKMAN COULTER, A63882) was used. AMPure XP beads were added to the ligation reaction solution, and after stirring, the mixture was left to stand at room temperature for 5 minutes. The mixture was placed on a magnetic stand and left to stand for 2 minutes, after which the supernatant was removed. 70% ethanol was added, the mixture was left to stand for 30 seconds, and the supernatant was removed. This process was repeated twice. The mixture was air-dried for 10 minutes.

[0120] (6) PCR reaction (second time) AmpliSeq for Illumina Library PLUS was used. Lib Amp Mix and Library Amp Primers were mixed, added to the purified sample, and mixed. The PCR reaction was performed in a thermal cycler to generate libraries (98°C for 2 minutes, followed by 7 cycles of 98°C for 15 seconds and 64°C for 1 minute, followed by a 10°C hold).

[0121] (7) Refining Purification was performed using the AMPure XP 450 mL Kit. AMPure XP beads were added to the PCR reaction solution, and the mixture was stirred and left to stand at room temperature for 5 minutes. The mixture was placed on a magnetic stand and left to stand for 5 minutes, after which the supernatant was removed. 70% ethanol was added, the mixture was left to stand for 30 seconds, and the supernatant was removed. This was repeated twice. The mixture was air-dried for 5 minutes. The mixture was removed from the magnetic stand, Low TE was added, and the mixture was stirred. The mixture was placed on a magnetic stand and left to stand for 5 minutes. The supernatant was collected and used as the NGS library.

[0122] (8) Quantification The KAPA Library Quantification Kit (KAPA BIOSYSTEMS) was used. The NGS library was adjusted to a specific concentration and mixed with KAPA Master Mix. The standard was also mixed with KAPA Master Mix. Quantification was performed using qPCR on a CFX96 Real-Time System.

[0123] (9) Sequence The PhiX Control kit v3 (Illumina TG-110-3001) was used. The library was diluted and denatured to ssDNA with 0.2N NaOH solution. HT1 was then added. PhiX control DNA was denatured in the same manner. These were added to the kit's reagent cartridge and sequenced on a MiSeq (Illumina).

[0124] Example 9: Gene Expression Data Processing Read data was imported into QIAGEN's CLC Genomics Workbench. The sequence information referenced during import was the Homo sapience sequence. Read data contains an error probability value for each base. When read data is imported into CLC Genomics Workbench, it is converted into a Phred Score. The Phred Score is calculated by taking the logarithm of the error probability of each base and multiplying it by -10 to generate a score (see formula below).

[0125] Phred Score = -10 × log 10 P err

[0126] Quality trimming was performed using the Phred Score. The quality trimming procedure is shown below. First, the Phred Score was converted to a p-value (following formula).

[0127] P err = 10 -phredScore / 10

[0128] Next, the difference between the limit (0.05) set during trimming and the p-value was calculated, and the cumulative sum of the differences was calculated. At this time, values ​​below 0 were set to 0. The read start point after trimming was the point where the cumulative sum first became 0 or greater, and the read end point after trimming was the point where the cumulative sum was maximum. After quality trimming, the read counts were converted to expression levels using the following procedure. First, the read sequences were aligned to the most similar region on the genome. Next, RPKM (Reads Per Kilobase Million) was calculated using the following formula:

[0129] RPKM = number of reads mapped to an exon region ÷ [total number of reads mapped to that sample (in millions) × exon length (kb)]

[0130] The value obtained by dividing RPKM by the sum of RPKM was calculated as TPM (Transcript Per Million). When logarithmically processing TPM, missing values ​​were processed using the formula "read count of each gene + (1 × gene length / average of gene length)", and then RPKM and TPM were calculated.

[0131] In addition, similar analysis results were obtained when missing values ​​were treated by using the minimum detected value or by inserting the lower detection limit value.

[0132] Example 10: Gene Expression Data Analysis The correlation coefficient and coefficient of determination for the measured gene group were calculated using the logarithmic TPM values ​​of each gene expression data. The correlation coefficient was calculated using the CORREL function employed in Microsoft Excel® described above, and the coefficient of determination was calculated using the RSQ function employed in Microsoft Excel® described above. The median values ​​of each cell population were also calculated: the median values ​​of the synovial MSC population, the median values ​​of the L bone marrow MSC population, and the median values ​​of the REC-MSC population. The coefficient of determination values ​​are shown in Table 3 below, compared to the cell values ​​for one lot.

[0133] [Table 3]

[0134] As a result, when controlling the quality of each MSC, it became possible to set boundary values ​​between it and other MSC populations, as well as between it and non-MSC populations.

[0135] For synovial MSCs, the coefficient of determination (CR) was 0.886 compared to synovial MSCs from a different lot, and 0.949 compared to the median of the synovial MSC population. Furthermore, comparisons with MSCs derived from other tissues yielded values ​​of 0.821, 0.786, 0.821, and 0.663, indicating that a threshold of 0.83 or higher can be used to define synovial MSCs within an MSC population. Furthermore, comparisons with non-MSC cell types yielded coefficients of determination ranging from 0.093 to 0.720, indicating that the threshold for tissue-derived MSCs can be set at around 0.75.

[0136] Furthermore, bone marrow MSCs have a coefficient of determination of 0.916 compared to synovial MSCs from a different lot, and a coefficient of determination of 0.961 compared to the median of the bone marrow MSC population. Furthermore, comparisons with MSCs derived from other tissues yielded coefficients of determination of 0.864, 0.873, 0.833, and 0.755, indicating that a threshold of 0.88 or higher can be used to define bone marrow MSCs within an MSC population. Furthermore, comparisons with non-MSC cell types yield coefficients of determination ranging from 0.111 to 0.773, indicating that the threshold for tissue-derived MSCs can be set at around 0.78.

[0137] Furthermore, for L-adipose MSCs, the coefficient of determination (CR) was 0.905 compared to synovial MSCs from a different lot, and 0.960 compared to the median of the adipose MSC population. Furthermore, when compared to MSCs derived from other tissues, the coefficients were 0.841, 0.823, 0.826, and 0.711, indicating that a threshold of 0.85 or higher can be used to define bone marrow MSCs within an MSC population. Furthermore, when compared to non-MSC cell types, the coefficients of determination were approximately 0.113 to 0.746, indicating that the threshold for tissue-derived MSCs can be set at approximately 0.75.

[0138] Furthermore, in both cases, iPSC-MSCs had a low coefficient of determination among MSC cell types, and were found to have properties that were so different from tissue-derived MSCs that they were indistinguishable from fibroblasts (FBs). This was considered a very reasonable result, considering that iPSC-MSCs are artificially produced through special differentiation induction and the manufacturing process is significantly different.

[0139] Furthermore, in consideration of the impact of including highly expressed genes on the measurement results and subsequent quality control, we prepared and performed a primer set (1143 genes) that did not include highly expressed genes and a primer set (1181 genes) that did include highly expressed genes, and found that the same results were possible with either primer set, and there was no difference between them. These results demonstrate that in cell quality control, managing the patterns of multiple gene expression groups specific to the cells in question is extremely useful for proving equivalence and homogeneity.

[0140] Example 11: Global gene expression analysis Human transcriptome sequencing analysis was performed at Riken Genesis Co., Ltd. on the mRNA samples of each cell prepared in Example 6. After sequencing analysis of the samples using NovaSeq6000 (Illumina, 20012850), the read data was analyzed using DRAGEN ver. 3.7.5 to calculate the gene expression levels of all 25,192 genes as TPM. The gene names of all 25,192 genes are listed at the end of this example.

[0141] The above-mentioned combinations of all 25,192 gene expressions and combinations of 1,143 genes randomly selected from all 25,192 gene expressions were analyzed in the same manner as in Example 10. Furthermore, the power of the analysis was calculated to compare the usefulness of gene sets in cell quality control. First, the coefficient of variation of each type of cell relative to the median of the target cell population for each gene set was calculated. Then, the statistical power was calculated based on the following formula:

[0142] Power (selected 1143 versus random 1143) = {coefficient of variation of "primer set 1143 gene expression excluding highly expressed genes selected in Example 7"} ÷ {coefficient of variation of "random 1143 gene expression randomly selected in Example 11"}

[0143] Power (1143 selected from a total of 25192) = {coefficient of variation of "expression of 1143 genes in the primer set excluding the highly expressed genes selected in Example 7"} ÷ {coefficient of variation of "expression of all 25192 genes obtained in Example 11"}

[0144] The coefficients of variation calculated as above and the coefficients of determination calculated in the same manner as in Example 10 are summarized in Tables 4, 5, and 6.

[0145] [Table 4]

[0146] [Table 5]

[0147] [Table 6]

[0148] The results showed that, whether using the full 25,192-gene set or a randomly selected set of 1,143 genes, it was possible to set boundaries between each MSC population and between each MSC population and non-MSC population during quality control. For example, in the case of synovial MSCs, the coefficient of determination (CR) between synovial MSCs from a different lot was 0.950 for 1,143 random genes and 0.947 for all 25,192 genes. The coefficient of determination between the CR and the median of the synovial MSC population was 0.978 for 1,143 random genes and 0.978 for all 25,192 genes. Furthermore, when compared with MSCs derived from other tissues, the coefficients were 0.950, 0.910, and 0.921 for the 1,143 random genes, and 0.928, 0.912, and 0.919 for all 25,192 genes. This suggests that defining synovial MSCs within an MSC population can be achieved by using a coefficient of determination threshold of 0.96 or higher for the 1,143 random genes and 0.93 or higher for all 25,192 genes. Furthermore, when compared with non-MSC cell types, the coefficients of determination were 0.541-0.896 for the random 1,143 genes and 0.592-0.886 for all 25,192 genes, indicating that threshold control for tissue-derived MSCs can be set to around 0.90 for both the random 1,143 genes and all 25,192 genes. Similar threshold control is also possible for bone marrow MSCs and adipose MSCs.

[0149] On the other hand, when comparing detection power, the 1,143 gene set selected in Example 7 showed 2.07 to 2.99 times the detection power when all 25,192 genes were used, and 1.90 to 4.67 times the detection power when 1,143 random genes were used, indicating that this is a gene set that can highly detect differences between various types of cells. In fact, the coefficient of determination for each cell type is significantly lower than when using a random 1,143-gene set or the full 25,192-gene set, demonstrating that this gene set is an excellent gene set for quality control in this cell type. Therefore, it is clear that the quality control of the present invention can be achieved using either the full gene set or a randomly selected gene set, and it has been demonstrated that even more accurate quality control is possible by selecting a more sensitive gene set.

[0150] DDX11L1、WASH7P、MIR1302-2、FAM138A、OR4F5、LOC729737、LOC100996522、LOC100132287、LOC100288646、OR4F29、OR4F16、LOC100133331、LOC1002880 69、LOC100287934、FAM87B、LINC00115、LOC643837、FAM41C、LOC284600、LOC100130417、SAMD11、NOC2L、KLHL17、PLEKHN1、C1orf170、HES4、ISG15、AGRN 、RNF223、C1orf159、LOC254099、MIR200B、MIR200A、MIR429、TTLL10、TNFRSF18、TNFRSF4、SDF4、B3GALT6、FAM132A、UBE2J2、SCNN1D、ACAP3、PUSL1、CPSF 3L、GLTPD1、TAS1R3、DVL1、MXRA8、AURKAIP1、CCNL2、LOC148413、MRPL20、ANKRD65、TMEM88B、VWA1、ATAD3C、ATAD3B、ATAD3A、TMEM240、SSU72、C1orf233 MIB2、MMP23B、CDK11B、SLC35E2B、MMP23A、CDK11A、SLC35E2、NADK、GNB1、CALML6、TMEM52、C1orf222、KIAA1751、GABRD、PRKCZ、C1orf86、SKI、MORN1、LOC 100129534、RER1、PEX10、PLCH2、PANK4、HES5、LOC115110、LOC100133445、TNFRSF14、LOC100996583、FAM213B、MMEL1、TTC34、ACTRT2、FLJ42875、LOC100 996587, PRDM16, MIR4251, ARHGEF16, MEGF6, MIR551A, TPRG1L, WRAP73, TP73, TP73-AS1, CCDC27, SMIM1, LRRC47, CEP104, DFFB, C1orf174, LOC100133612, LOC728716, LOC284661, AJAP1, MIR4417, MIR4689, NPHP4, KCNAB2, CHD5, RPL22, RNF207, ICMT, 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TED4、CTPS1、SLFNL1-AS1、SLFNL1、SCMH1、FOXO6、EDN2、HIVEP3、GUCA2B、GU CA2A、FOXJ3、RIMKLA、ZMYND12、PPCS、CCDC30、PPIH、YBX1、CLDN19、LEPRE1、C 1orf50、LOC100129924、CCDC23、ERMAP、ZNF691、SLC2A1、SLC2A1-AS1、FAM1 83A、EBNA1BP2、WDR65、TMEM125、C1orf210、TIE1、MPL、CDC20、ELOVL1、MED8、SZT2、HYI、PTPRF、KDM4A、KDM4A-AS1、ST3GAL3、ARTN、IPO13、DPH2、ATP6V0B 、B4GALT2、CCDC24、SLC6A9、KLF17、DMAP1、ERI3、RNF220、MIR5584、TMEM53、 C1orf228、RNU5F-1、RNU5D-1、KIF2C、RPS8、SNORD55、SNORD46、SNORD38A、S NORD38B、BEST4、PLK3、TCTEX1D4、BTBD19、PTCH2、EIF2B3、HECTD3、UROD、ZSW IM5、LOC400752、HPDL、MUTYH、TOE1、TESK2、CCDC163P、MMACHC、PRDX1、AKR1 A1、NASP、CCDC17、GPBP1L1、RPS15AP10、TMEM69、IPP、MAST2、PIK3R3、TSPAN 1、POMGNT1、LURAP1、RAD54L、LRRC41、UQCRH、NSUN4、FAAH、LOC729041、DMBX 1、MKNK1-AS1、KNCN、MKNK1、MOB3C、ATPAF1、TEX38、KIAA0494-AS1、KIAA0494 、CYP4B1、CYP4Z2P、CYP4A11、CYP4X1、CYP4Z1、CYP4A22、PDZK1IP1-AS1、PDZ K1IP1、TAL1、STIL、CMPK1、FOXE3、FOXD2-AS1、FOXD2、TRABD2B、SKINTL、SLC 5A9、SPATA6、AGBL4、BEND5、ELAVL4、DMRTA2、FAF1、CDKN2C、MIR4421、C1orf 185、RNF11、TTC39A、EPS15、OSBPL9、NRD1、MIR761、RAB3B、TXNDC12、KTI12、B TF3L4、ZFYVE9、CC2D1B、ORC1、PRPF38A、ZCCHC11、GPX7、FAM159A、SELRC1、Z YG11B、ZYG11A、ECHDC2、SCP2、MIR1273F、MIR5095、MIR1273G、PODN、SLC1A7 、CPT2、C1orf123、MAGOH、LOC100507564、LRP8、SLC25A3P1、DMRTB1、GLIS1、 TMEM48、YIPF1、DIO1、HSPB11、LRRC42、LDLRAD1、TMEM59、TCEANC2、MIR4781、CDCP2、CYB5RL、MRPL37、SSBP3、C1orf191、ACOT11、FAM151A、HEATR8、HEATR8-TTC4、TTC4、PARS2、TTC22、C1orf177、DHCR24、TMEM61、BSND、PCSK9、USP24、 LOC100507634、MIR4422、LOC100507652、PPAP2B、PRKAA2、C1orf168、C8A、C 8B、DAB1、OMA1、TACSTD2、MYSM1、JUN、LOC100131060、HSD52、FGGY、MIR4711 、HOOK1、CYP2J2、C1orf87、LOC100996570、NFIA、TM2D1、INADL、MIR3116-1、 MIR3116-2、L1TD1、KANK4、USP1、DOCK7、ANGPTL3、LOC100507664、LOC400756 、ATG4C、LINC00466、LOC100996301、FOXD3、ALG6、ITGB3BP、EFCAB7、DLEU2L 、PGM1、ROR1、UBE2U、CACHD1、MIR4794、RAVER2、JAK1、MIR3671、MIR101-1、A K4、DNAJC6、LEPROT、LEPR、PDE4B、SGIP1、MIR3117、TCTEX1D1、INSL5、WDR78 、MIER1、SLC35D1、C1orf141、IL23R、IL12RB2、SERBP1、GADD45A、GNG12、GNG1 2-AS1、DIRAS3、WLS、MIR1262、RPE65、DEPDC1、LRRC7、PIN1P1、LRRC40、SRSF 11、ANKRD13C、HHLA3、CTH、PTGER3、ZRANB2-AS1、ZRANB2、MIR186、ZRANB2-A S2、NEGR1、NEGR1-IT1、LRRIQ3、FPGT-TNNI3K、FPGT、TNNI3K、C1orf173、CRY Z、TYW3、LHX8、SLC44A5、ACADM、RABGGB、SNORD45C、SNORD45A、SNORD45B、MS H4、ASB17、ST6GALNAC3、ST6GALNAC5、PIGK、AK5、ZZZ3、USP33、FAM73A、NEXN -AS1、NEXN、FUBP1、DNAJB4、GIPC2、MGC27382、PTGFR、IFI44L、IFI44、ELTD1 、LPHN2、TTLL7、PRKACB、SAMD13、UOX、DNASE2B、RPF1、GNG5、SPATA1、CTBS、C 1orf180、SSX2IP、LPAR3、MCOLN2、MCOLN3、WDR63、MIR4423、SYDE2、C1orf52、BCL10、LOC646626、DDAH1、CYR61、ZNHIT6、COL24A1、ODF2L、CLCA2、CLCA1、CLCA4、CLCA3P、SH3GLB1、SEP15、HS2ST1、LOC339524、LMO4、LOC100505768、P KN2、GTF2B、CCBL2、RBMXL1、GBP3、GBP1、GBP2、GBP7、GBP4、GBP5、GBP6、GBP1P1、LRRC8B、FLJ27354、LRRC8C、LRRC8D、GEMIN8P4、ZNF326、BARHL2、LOC1493 51、LOC100505840、ZNF644、LOC100996620、HFM1、CDC7、HSP90B3P、TGFBR3、BRDT、EPHX4、BTBD8、KIAA1107、C1orf146、GLMN、RPAP2、GFI1、EVI5、RPL5、FA M69A、SNORD21、SNORA66、MTF2、TMED5、CCDC18、LOC100131564、DR1、FNBP1L、BCAR3、LOC100129046、LOC100132240、MIR760、DNTTIP2、GCLM、ABCA4、ARHG AP29、LOC100505940、ABCD3、F3、MIR378G、SLC44A3、CNN3、LOC729970、ALG14、TMEM56、TMEM56-RWDD3、RWDD3、LOC100996630、FLJ31662、LOC100996635 、PTBP2、DPYD、DPYD-AS1、MIR137HG、MIR2682、MIR137、LOC729987、SNX7、LPPR5、LOC100129620、LPPR4、PALMD、FRRS1、AGL、LOC730081、SLC35A3、HIAT1、 SASS6, TRMT13, LRRC39, DBT, LOC100506007, RTCA, MIR553, CDC14A, GPR88, LOC100128787, VCAM1, EXTL2, SLC30A7, DPH5, LOC100506051, S1PR1, OLFM3, DNAJA1P5, COL11A1, RNPC3, AMY2B, ACTG1P4, AMY2A, AMY1A, AMY1B, AMY1C, LOC100129138, PRMT6, NTNG1, VAV3, VAV3-AS1, SLC25A24, NBPF4, LOC400768,NBPF6、FAM102B、HENMT1、PRPF38B、FNDC7、STXBP3、AKNAD1、SRG7、GPSM2、CLCC1、WDR47、TAF13、TMEM167B、SCARNA2、C1orf194、KIAA1324、SARS、CELSR2、PSRC1、 MYBPHL, SORT1, PSMA5, SYPL2, ATXN7L2, CYB561D1, AMIGO1, GPR61, GNAI3, MIR197, GNAT2, AMPD2, GSTM4, GSTM2, GSTM1, GSTM5, GSTM3, EPS8L3, CSF1, AH CYL1, STRIP1, ALX3, UBL4B, SLC6A17, KCNC4, LOC440600, RBM15, SLC16A4, LAMTOR5, PROK1, CYMP, KCNA10, KCNA2, KCNA3, CD53, LRIF1, DRAM2, CEPT1, DEN ND2D, CHI3L2, CHIAP2, CHIA, PIFO, PGCP1, OVGP1, WDR77, ATP5F1, C1orf162, ADORA3, LOC100129269, RAP1A, FAM212B, LOC100506343, DDX20, KCND3, LOC643355, CTTNBP2NL, MIR4256, WNT2B, ST7L, CAPZA1, MOV10, RHOC, PPM1J, FAM19A3, LOC128322, LOC100996702, SLC16A1, AKR7A2P1, LOC100506392, LOC 100996251、LRIG2、LOC643441、MAGI3、PHTF1、RSBN1、PTPN22、AP4B1-AS1、BCL2L15、AP4B1、DCLRE1B、HIPK1、OLFML3、SYT6、TRIM33、BCAS2、DENND2C、AM PD1, NRAS, CSDE1, SIKE1, SYCP1, TSHB, TSPAN2, NGF, VANGL1, CASQ2, NHLH2, SLC22A15, MAB21L3, ATP1A1, ATP1A1OS, LOC100506459, CD58, MIR548AC, IGS F3、MIR320B1、CD2、PTGFRN、CD101、TTF2、MIR942、TRIM45、LOC100506478、VTCN1、MAN1A2、LOC100996263、FAM46C、GDAP2、WDR3、SPAG17、TBX15、WARS2、 HAO2、HSD3B2、HSD3B1、HSD3BP4、LINC00622、ZNF697、PHGDH、HMGCS2、REG4、NBPF7、ADAM30、NOTCH2、LOC100132913、FAM72B、HIST2H2BA、LOC100996318、FCGR1B、EMBP1、MIR3118-1、ANKRD20A12P、MIR3118-2、MIR3118-3、LOC1001 30000、LOC100286793、LOC100996473、PPIAL4G、FAM72D、SRGAP2B、LINC006 23、LOC730256、PPIAL4B、LOC728875、PFN1P2、LOC653513、NBPF9、PDE4DIP、 LOC100996517、NUDT4P1、NOTCH2NL、NBPF10、HFE2、TXNIP、POLR3GL、ANKRD34 A、LIX1L、RBM8A、GNRHR2、PEX11B、ITGA10、ANKRD35、PIAS3、NUDT17、POLR3C 、RNF115、CD160、PDZK1、GPR89A、GPR89C、PDZK1P1、RNU1-9、NBPF11、LOC1005 06011、LOC100509195、HYDIN2、LOC100996529、LOC728989、PRKAB2、PDIA3P 、FMO5、CHD1L、LINC00624、BCL9、ACP6、GJA5、GJA8、GPR89B、RNU1-6、NBPF24、 LOC100505824、MIR5087、LOC100996555、FLJ39739、LOC100132999、PPIAL4 A、NBPF14、PPIAL4D、NBPF15、PPIAL4E、NBPF16、PPIAL4F、FLJ37786、LOC645 166、RNU1-5、LOC388692、FCGR1C、FAM72C、PPIAL4C、FAM91A2、LOC642441、L OC644634、HIST2H2BF、FCGR1A、HIST2H3D、HIST2H4A、HIST2H3C、HIST2H2AA3 、HIST2H2BC、HIST2H2AA4、HIST2H3A、HIST2H4B、HIST2H2BE、HIST2H2AC、HI ST2H2AB、BOLA1、SV2A、SF3B4、MTMR11、OTUD7B、VPS45、PLEKHO1、ANP32E、CA1 4、APH1A、C1orf54、C1orf51、MRPS21、PRPF3、RPRD2、TARS2、ECM1、LINC0056 8、ADAMTSL4、LOC100996516、MIR4257、MCL1、ENSA、GOLPH3L、HORMAD1、CTSS、CTSK、ARNT、LOC100996521、SETDB1、CERS2、ANXA9、FAM63A、PRUNE、BNIPL、C1orf56、CDC42SE1、MLLT11、GABPB2、SEMA6C、TNFAIP8L2-SCNM1、TNFAIP8L2、LYSMD1、SCNM1、TMOD4、 VPS72、PIP5K1A、PSMD4、LOC100507670、ZNF687、PI4KB、RFX5、SELENBP1、PSMB4、POGZ、CGN、TUFT1、MIR554、SNX27、CELF3、RIIAD1、MRPL9、OAZ3、TDRKH、LINGO4、RORC、C2CD4D、LOC100132111、THEM5、THEM4、S100A10、S100A11、LOC100131107、TCHHL1、TCHH、RPTN、HRNR、FLG、FLG-AS1、FLG2、CRNN、LCE5A、CRCT1、LCE3E、LCE3D、LCE3C、LCE3B、LCE3A、LCE2D、LCE2C、LCE2B、LCE2A、LCE4A、C1orf68、KPRP、LCE1F、LCE1E、LCE1D、LCE1C、LCE1B、LCE1A、LCE6A、SMCP、IVL、SPRR4、SPRR1A、SPRR3、SPRR1B、SPRR2D、SPRR2A、SPRR2B、SPRR2E、SPRR2F、SPRR2C、SPRR2G、LELP1、PRR9、LOR、PGLYRP3、PGLYRP4、S100A9、S100A12、S100A8、S100A7A、S100A7L2、S100A7、S100A6、S100A5、S100A4、S100A3、S100A2、S100A16、S100A14、S100A13、S100A1、CHTOP、SNAPIN、ILF2、NPR1、INTS3、SLC27A3、GATAD2B、DENND4B、CRTC2、SLC39A1、CREB3L4、JTB、RAB13、RPS27、NUP210L、MIR5698、TPM3、MIR190B、C1orf189、C1orf43、UBAP2L、HAX1、AQP10、ATP8B2、IL6R、SHE、TDRD10、UBE2Q1、CHRNB2、ADAR、KCNN3、PMVK、PBXIP1、PYGO2、SHC1、CKS1B、MIR4258、FLAD1、LENEP、ZBTB7B、DCST2、DCST1、LOC100505666、ADAM15、EFNA4、EFNA3、EFNA1、SLC50A1、DPM3、KRTCAP2、TRIM46、MUC1、MIR92B、THBS3、MTX1、GBAP1、GBA、FAM189B、SCAMP3、CLK2、HCN3、PKLR、FDPS、RUSC1-AS1、RUSC1、ASH1L、MIR555、POU5F1P4、ASH1L-AS1、MSTO1、YY1AP1、D AP3、MSTO2P、GON4L、SYT11、RIT1、KIAA0907、SNORA42、SCARNA4、RXFP4、ARH GEF2、SSR2、UBQLN4、LAMTOR2、RAB25、MEX3A、LMNA、SEMA4A、SLC25A44、PMF1 -BGLAP、PMF1、BGLAP、PAQR6、SMG5、TMEM79、C1orf85、VHLL、CCT3、TSACC、RHB G、C1orf61、MIR9-1、MEF2D、IQGAP3、TTC24、APOA1BP、GPATCH4、HAPLN2、BCA N、NES、CRABP2、ISG20L2、RRNAD1、MRPL24、HDGF、PRCC、SH2D2A、NTRK1、INSRR 、PEAR1、LRRC71、ARHGEF11、MIR765、ETV3L、ETV3、CYCSP52、FCRL5、FCRL4、F CRL3、FCRL2、FCRL1、CD5L、KIRREL、KIRREL-IT1、LOC646268、CD1D、LOC10050 5799、CD1A、CD1C、CD1B、CD1E、OR10T2、OR10K2、OR10K1、OR10R2、OR6Y1、OR6 P1、OR10X1、OR10Z1、SPTA1、OR6K2、OR6K3、OR6K6、OR6N1、OR6N2、MNDA、PYHI N1、IFI16、AIM2、CADM3、LOC100131825、DARC、FCER1A、OR10J3、OR10J1、OR1 0J5、APCS、CRP、DUSP23、FCRL6、SLAMF8、C1orf204、VSIG8、CCDC19、TAGLN2、I GSF9、SLAMF9、LOC100505633、PIGM、KCNJ10、KCNJ9、IGSF8、ATP1A2、ATP1A4 、CASQ1、PEA15、DCAF8、LOC100287049、PEX19、COPA、SUMO1P3、NCSTN、NHLH1、 VANGL2、SLAMF6、CD84、SLAMF1、CD48、SLAMF7、LY9、CD244、ITLN1、ITLN2、F1 1R、TSTD1、USF1、ARHGAP30、PVRL4、KLHDC9、PFDN2、NIT1、DEDD、UFC1、USP21、PPOX, B4GALT3, ADAMTS4, NDUFS2, FCER1G, APOA2, TOMM40L, MIR5187, NR1I3, PCP4L1, MPZ, SDHC, C1orf192, FCGR2A, HSPA6, FCGR3A, FCGR2C、HSPA7、FCGR3B、FCGR2B、RPL31P11、FCRLA、FCRLB、DUSP12、ATF6、OLFML2B、NOS1AP、MIR4654、MIR556、C1orf111、C1orf226、SH2D1B、UHMK1、UAP1 、DDR2、HSD17B7、C1orf110、RGS4、RGS5、NUF2、PBX1、LOC100505795、LMX1A、RXRG、LOC400794、LRRC52、MGST3、LOC100505828、ALDH9A1、LOC440700、TMCO 1、UCK2、MIR3658、FAM78B、MIR921、FMO9P、POGK、TADA1、ILDR2、MAEL、GPA33、DUSP27、POU2F1、CD247、CREG1、RCSD1、LOC100128751、MPZL1、ADCY10、MPC2 、DCAF6、MIR1255B2、GPR161、TIPRL、SFT2D2、ANKRD36BP1、LOC100996595、TBX19、MIR557、LOC100505918、XCL2、XCL1、DPT、LINC00626、ATP1B1、NME7、BL ZF1, C1orf114, SLC19A2, LOC100287813, F5, SELP, SELL, SELE, METTL18, C1orf112, SCYL3, KIFAP3, METTL11B, MIR3119-1, MIR3119-2, LOC284688, GORAB, PRRX1, LOC100127910, C1orf129, FMO3, MIR1295A, MIR1295B, FMO6P, FMO2, FMO1, FMO4, TOP1P1, PRRC2C, MYOC, VAMP4, METTL13, DNM3, DNM3OS, MIR214 、MIR3120、MIR199A2、LOC100505991、C1orf105、PIGC、SUCO、FASLG、TNFSF18、TNFSF4、LOC100506023、PRDX6、SLC9C2、ANKRD45、LOC730159、KLHL20、CEN PL、DARS2、GAS5-AS1、GAS5、SNORD81、SNORD47、SNORD80、SNORD79、SNORD78、SNORD44、SNORD77、SNORD76、SNORD75、SNORD74、ZBTB37、SERPINC1、RC3H1、RABGAP1L, GPR52, CACYBP, MRPS14, TNN, KIAA0040, TNR, RFWD2, SCARNA3, PAPPA2, ASTN1, MIR488, FAM5B, LOC100506128, SEC16B, LOC730102, RASAL2-AS1, RASAL2, LINC00083, TEX35, C1orf220, MIR4424, RALGPS2, ANGPTL1, FAM20B, TOR3A, ABL2, SOAT1, AXDND1, NPHS2, TDRD5, LOC100506206, FAM163A, TO R1AIP2, TOR1AIP1, CEP350, QSOX1, FLJ23867, LHX4, LOC100527964, ACBD6, MIR3121, XPR1, KIAA1614, STX6, MR1, IER5, GM140, CACNA1E, ZNF648, GLUL, TEDDM1, LINC00272, RGSL1, RNASEL, RGS16, LOC284648, RGS8, NPL, DHX9, SHCBP1L, LAMC1, LAMC2, NMNAT2, SMG7-AS1, SMG7, NCF2, ARPC5, RGL1, APOBEC4, GLT25D2, TSEN15, C1orf21, EDEM3, FAM129A, RNF2, TRMT1L, LOC100996636, SWT1, IVNS1ABP, LOC100288079, HMCN1, PRG4, TPR, C1orf27, OCLM, PDC, PTG S2, PLA2G4A, FAM5C, LOC440704, LOC100652834, RGS18, RGS21, RGS1, RGS13, MIR4426, RGS2, UCHL5, TROVE2, GLRX2, CDC73, MIR1278, B3GALT2, KCNT2, MI R4735、CFH、CFHR3、CFHR1、CFHR4、CFHR2、CFHR5、F13B、ASPM、ZBTB41、CRB1、DENND1B、C1orf53、LHX9、NEK7、ATP6V1G3、PTPRC、LOC100131234、MIR181B1 、MIR181A1、NR5A2、FAM58BP、C1orf98、ZNF281、KIF14、DDX59、CAMSAP2、GPR25、C1orf106、KIF21B、LOC100506546、CACNA1S、ASCL5、TMEM9、IGFN1、PKP1、TNNT2、LAD1、TNNI1、PHLDA3、CSRP1、RPS10P7、NAV1、MIR5191、MIR1231、IPO9、SHISA4、LMOD1、TIMM17A、RNPEP、ELF3、GPR37L1、ARL8A、PTPN7、PTPRVP、LGR6、UBE2T、 PPP1R12B, SYT2, KDM5B, KDM5B-AS1, LOC641515, LOC148709, RABIF, KLHL12, ADIPOR1, CYB5R1, TMEM183A, PPFIA4, MYOG, ADORA1, MYBPH, CHI3L1, CHIT1, LOC100506775、LOC730227、BTG2、FMOD、PRELP、OPTC、ATP2B4、SNORA77、LINC00260、LAX1、ZC3H11A、ZBED6、SNRPE、LINC00303、SOX13、ETNK2、REN、KISS1 、GOLT1A、PLEKHA6、LINC00628、PPP1R15B、PIK3C2B、MDM4、LRRN2、NFASC、CNTN2、TMEM81、RBBP5、DSTYK、TMCC2、NUAK2、KLHDC8A、LEMD1-AS1、LEMD1、MIR1 35B、CDK18、LOC284578、MFSD4、ELK4、SLC45A3、NUCKS1、RAB7L1、SLC41A1、PM20D1、LOC284581、SLC26A9、LOC100505630、FAM72A、AVPR1B、C1orf186、LOC 100505650, CTSE, SRGAP2, IKBKE, RASSF5, EIF2D, DYRK3, MAPKAPK2, IL10, IL19, IL20, IL24, FAIM3, PIGR, FCAMR, C1orf116, YOD1, PFKFB2, C4BPB, C4BPA, CD55, CR2, CR1, CR1L, CD46, MIR29C, MIR29B2, LOC148696, CD34, PLXNA2, LOC100506899, LOC100509303, MIR205HG, MIR205, CAMK1G, LAMB3, MIR4260, G 0S2、HSD11B1、TRAF3IP3、C1orf74、IRF6、DIEXF、SYT14、SERTAD4-AS1、SERTAD4、HHAT、KCNH1、RCOR3、TRAF5、LINC00467、RD3、SLC30A1、NEK2、LPGAT1、IN TS7, DTL, RPL21P28, MIR3122, PPP2R5A, SNORA16B, TMEM206, NENF, ATF3, FAM71A, BATF3, NSL1, TATDN3, C1orf227, FLVCR1-AS1, FLVCR1, VASH2, ANGEL2,RPS6KC1、LINC00538、PROX1、SMYD2、PTPN14、CENPF、KCNK2、KCTD3、USH2A、E SRRG、GPATCH2、SPATA17、LINC00210、RRP15、LOC728463、TGFB2、LOC643723 、LYPLAL1、SLC30A10、EPRS、BPNT1、IARS2、MIR215、MIR194-1、RAB3GAP2、MI R664、SNORA36B、AURKAPS1、MARK1、C1orf115、MARC2、MARC1、HLX、C1orf140、 DUSP10、HHIPL2、TAF1A、LOC100506161、MIA3、AIDA、BROX、FAM177B、DISP1、 TLR5、SUSD4、C1orf65、CAPN8、CAPN2、TP53BP2、LOC100288102、LOC10028749 7, LOC100996486, FBXO28, DEGS1, NVL, MIR320B2, CNIH4, WDR26, MIR4742, CNIH3, DNAH14, LBR, ENAH, SRP9, EPHX1, TMEM63A, LEFY1, PYCR2, LEFY2, SDE 2、H3F3A、ACBD3、MIXL1、LIN9、PARP1、C1orf95、ITPKB、ITPKB-IT1、PSEN2、A DCK3、CDC42BPA、ZNF678、LOC100130093、JMJD4、SNAP47、PRSS38、WNT9A、MIR 5008、LOC728728、LOC100996502、WNT3A、LOC100506571、ARF1、MIR3620、C1 orf35、MRPL55、GUK1、GJC2、C1orf148、IBA57、C1orf145、OBSCN、TRIM11、TRI M17, HIST3H3, HIST3H2A, HIST3H2BB, MIR4666A, RNF187, BTNL10, RNA5S1, RNA5S2, RNA5S3, RNA5S4, RNA5S5, RNA5S6, RNA5S7, RNA5S8, RNA5S9, RNA5S10 RNA5S11、RNA5S12、RNA5S13、RNA5S14、RNA5S15、RNA5S16、RHOU、DUSP5P1、R NA5S17、RAB4A、SPHAR、CCSAP、ACTA1、NUP133、ABCB10、TAF5L、URB2、GALNT2、PGBD5、COG2、AGT、CAPN9、C1orf198、TTC13、ARV1、FAM89A、MIR1182、TRIM67、LOC149373、C1orf131、GNPAT、EXOC8、SPRTN、EGLN1、SNRPD2P2、TSNAX-DISC1、TSNAX、LINC00582、 DISC1、DISC2、SIPA1L2、KIAA1383、NTPCR、PCNXL2、KIAA1804、KCNK1、MIR44 27、SLC35F3、MIR4671、COA6、TARBP1、LOC100506795、IRF2BP2、LINC00184、L OC100506810、PP2672、TOMM20、SNORA14B、RBM34、ARID4B、MIR4753、GGPS1、 TBCE、B3GALNT2、GNG4、LYST、MIR1537、NID1、GPR137B、ERO1LB、EDARADD、LGA LS8、LGALS8-AS1、HEATR1、ACTN2、MTR、RYR2、MIR4428、LOC100130331、ZP4、 LOC339535、CHRM3、CHRM3-AS2、RPS7P5、FMN2、GREM2、LOC100506929、RGS7、M IR3123, FH, KMO, OPN3, CHML, WDR64, EXO1, MAP1LC3C, PLD5, LOC100505955, LOC731275, CEP170, SDCCAG8, MIR4677, AKT3, LOC339529, ZNF238, LOC44074 2、C1orf100、ADSS、C1orf101、DESI2、COX20、HNRNPU-AS1、HNRNPU、EFCAB2、 KIF26B、SMYD3、LOC255654、TFB2M、CNST、SCCPDH、LOC100130097、LOC149134 、AHCTF1、ZNF695、ZNF670-ZNF695、ZNF670、ZNF669、C1orf229、ZNF124、MIR 3916、VN1R5、ZNF496、NLRP3、OR2B11、OR2W5、GCSAML-AS1、OR2C3、GCSAML、OR 2G2, OR2G3, OR13G1, OR6F1, OR1C1, OR14A16, OR11L1, TRIM58, OR2W3, OR2T8, OR2L13, OR2L8, OR2AK2, OR2L1P, OR2L5, OR2L2, OR2L3, OR2M1P, OR2M5, OR2M 2, OR2M3, OR2M4, OR2T33, OR2T12, OR2M7, OR14C36, OR2T4, OR2T6, OR2T1, OR2T2, OR2T3, OR2T5, OR2G6, OR2T29, OR2T34, OR2T10, OR2T11, OR2T35, OR2T27OR14I1、LYPD8、SH3BP5L、MIR3124、ZNF672、ZNF692、PGBD2、TUBB8、ZMYND11、DIP2C、MIR5699、C10orf108、LARP4B、LOC100288619、GTPBP4、IDI2、IDI2-A S1、IDI1、WDR37、LINC00200、ADARB2、LOC642422、ADARB2-AS1、LOC282980、LOC399708、PFKP、PITRM1、LOC100507034、KLF6、LOC100652988、LOC1005070 59、LOC100128356、LOC100216001、LOC338588、AKR1E2、TAKR、AKR1C1、AKR1C2、AKR1C3、AKR1CL1、AKR1C4、UCN3、TUBAL3、NET1、CALML5、LOC100132159、C ALML3、ASB13、FAM208B、GDI2、ANKRD16、FBXO18、IL15RA、IL2RA、RBM17、PFKFB3、MIR3155A、MIR3155B、LOC399715、DKFZp667F0711、PRKCQ、LOC439949、L OC100507127、SFMBT2、ITIH5、ITIH2、KIN、ATP5C1、TAF3、FLJ45983、GATA3、LOC100507143、LOC100507163、SFTA1P、LOC254312、CELF2、LOC439950、CELF 2-AS1、USP6NL、LOC100507213、ECHDC3、C10orf47、LOC219731、UPF2、DHTKD1、SEC61A2、MIR548AK、NUDT5、CDC123、CAMK1D、MIR4480、MIR4481、MIR548Q、 LOC283070、CCDC3、OPTN、MCM10、RNU6-2、UCMA、PHYH、SEPHS1、BEND7、PRPF18、FRMD4A、MIR4293、MIR1265、FAM107B、CDNF、HSPA14、SUV39H2、DCLRE1C、ME IG1、LOC100289151、OLAH、ACBD7、C10orf111、RPP38、NMT2、LOC100192204、FAM171A1、ITGA8、FAM188A、PTER、C1QL3、RSU1、CUBN、TRDMT1、LOC100507347、VIM、ST8SIA6、LOC100128098、PTPLA、STAM、TMEM236、MIR511-1、MRC1、MIR511-2、SLC39A12、LOC100129213、CACNB2、NSUN6、ARL5B、PLXDC2、MIR4675、NEBL、C10orf113、LOC100128511、 RNU6-15、C10orf114、MIR1915、SKIDA1、MLLT10、DNAJC1、LOC100507445、EB LN1、LOC100130992、COMMD3-BMI1、COMMD3、BMI1、SPAG6、LOC100499489、LO C100289455、PIP4K2A、ARMC3、MSRB2、PTF1A、C10orf67、MIR1254-2、OTUD1、 KIAA1217、MIR603、ARHGAP21、PRTFDC1、ENKUR、THNSL1、GPR158-AS1、GPR158 、LOC100507531、MYO3A、GAD2、APBB1IP、LINC00264、LOC731789、PDSS1、ABI 1、LINC00202、ANKRD26、YME1L1、MASTL、ACBD5、LRRC37A6P、PTCHD3、RAB18、 MKX、ARMC4、MPP7、WAC-AS1、WAC、BAMBI、LOC100507605、C10orf126、LYZL1、 LOC387647、SVIL、MIR604、MIR938、KIAA1462、MTPAP、MAP3K8、LYZL2、ZNF438 、LOC100507663、ZEB1-AS1、ZEB1、LOC100996668、ARHGAP12、KIF5B、EPC1、C CDC7、C10orf68、ITGB1、NRP1、LOC100505583、PARD3、LOC100505601、CUL2、 MIR3611, CREM, CCNY, GJD4, FZD8, MIR4683, ANKRD30A, MTRNR2L7, ZNF248, LOC100419868, ZNF25, ZNF33A, ZNF37A, LOC100129055, HSD17B7P2, SEPT7L, L OC399744、ACTR3BP5、LOC441666、LOC84856、ZNF37BP、ZNF33B、BMS1、MIR51 00、RET、CSGALNACT2、RASGEF1A、FXYD4、HNRNPF、ZNF487P、LOC100996605、Z NF239, ZNF485, ZNF32-AS3, ZNF32, ZNF32-AS1, ZNF32-AS2, HNRNPA3P1, LINC00619, LOC100506835, LOC283033, LOC100506853, LOC100130539, CXCL12TMEM72-AS1、TMEM72、RASSF4、C10orf10、C10orf25、ZNF22、RSU1P2、LOC338579、MIR3156-1、OR13A1、ALOX5、MARCH8、ZFAND4、FAM21C、AGAP4、PTPN20A、 BMS1P1、GLUD1P7、FAM35B、SYT15、GPRIN2、PPYR1、LOC643650、LOC728643、ANXA8L1、FAM25B、AGAP10、BMS1P2、FAM35B2、LOC100996567、ANTXRL、ANXA8L2 , FAM21B, CTSL1P2, BMS1P6, AGAP9, FAM25G, ANXA8, ZNF488, RBP3, GDF2, GDF10, PTPN20B, FRMPD2P1, BMS1P5, FAM25C, FRMPD2, MAPK8, ARHGAP22, WDFY4, LRRC18, MIR4294, VSTM4, LOC100506733, FAM170B, C10orf128, LOC100506769, C10orf71, DRGX, ERCC6, PGBD3, CHAT, SLC18A3, C10orf53, OGDHL, PARG, AG AP8、LOC728407、TIMM23B、AGAP7、MSMB、NCOA4、TIMM23、LOC100996610、LOC100652748、AGAP6、FAM21A、ASAH2、SGMS1、ASAH2B、A1CF、PRKG1、MIR605、CST F2T、LOC100506939、DKK1、MBL2、PCDH15、MIR548F1、MTRNR2L5、ZWINT、MIR3924、IPMK、CISD1、UBE2D1、TFAM、BICC1、FAM133CP、LOC100507008、PHYHIPL、 FAM13C、SLC16A9、M1、CCDC6、C10orf40、ANK3、CDK1、RHOBTB1、LOC100507058、TMEM26、C10orf107、ARID5B、RTKN2、ZNF365、ADO、EGR2、NRBF2、JMJD1C、MI R1296、LOC84989、REEP3、ANXA2P3、CTNNA3、LRRTM3、DNAJC12、SIRT1、HERC4、MYPN、ATOH7、PBLD、HNRNPH3、RUFY2、DNA2、LOC100996629、SLC25A16、TET1、CCAR1、SNORD98、MIR1254-1、STOX1、DDX50、DDX21、KIAA1279、SRGN、VPS26A、SUPV3L1、HKDC1、HK1、TACR2、TSPAN15、NEUROG3、C10orf35、COL13A1、H2AFY2、AIFM2、TYSND1、SAR1A、PPA1、 NPFFR1、LRRC20、EIF4EBP2、NODAL、PALD1、PRF1、ADAMTS14、TBATA、SGPL1、PCBD1、UNC5B、LOC728978、SLC29A3、CDH23、C10orf105、C10orf54、PSAP、CHST3、SPOCK2、ASCC1、ANAPC16、DDIT4、DNAJB12、MICU1、MCU、MIR4676、OIT3、PLA2G12B、P4HA1、NUDT13、ECD、FAM149B1、DNAJC9、DNAJC9-AS1、MRPS16、TTC18、ANXA7、MSS51、PPP3CB、USP54、MYOZ1、SYNPO2L、AGAP5、BMS1P4、GLUD1P3、SEC24C、FUT11、CHCHD1、ZSWIM8、LOC100507331、NDST2、CAMK2G、C10orf55、PLAU、VCL、AP3M1、ADK、KAT6B、DUPD1、DUSP13、SAMD8、VDAC2、COMTD1、ZNF503-AS1、ZNF503、ZNF503-AS2、MIR606、C10orf11、KCNMA1、DLG5、LOC100131132、LOC100128292、POLR3A、RPS24、LOC100132987、LOC283050、ZMIZ1、PPIF、ZCCHC24、EIF5AL1、SFTPA2、SFTPA1、LOC650623、LOC642361、LOC100288974、MBL1P、SFTPD、TMEM254-AS1、TMEM254、PLAC9、ANXA11、LOC439990、LOC100130698、MAT1A、DYDC1、DYDC2、FAM213A、TSPAN14、SH2D4B、NRG3、GHITM、C10orf99、CDHR1、LRIT2、LRIT1、RGR、LOC170425、FAM190B、GRID1-AS1、GRID1、MIR346、WAPAL、OPN4、LDB3、BMPR1A、MMRN2、SNCG、C10orf116、AGAP11、FAM25A、GLUD1、FAM35A、FAM22A、LOC728190、LOC439994、FAM22D、LOC728218、MIR4678、MINPP1、PAPSS2、ATAD1、CFL1P1、KLLN、PTEN、RNLS、LIPJ、LIPF、LIPK、LIPN、LIPM、ANKRD22、STAMBPL1、LOC100132116、ACTA2、FAS、FAS-AS1、MIR4679-2、MIR4679-1、CH25H、LIPA、IFIT2、IFIT3、IFIT1B、IFIT1、IFIT5、SLC16A12、PANK1、MIR107、FLJ37201、KIF20B、LOC643529、HTR7、RPP30、ANKRD1、LINC00502、NUDT9P1、PCGF5、LOC100188947、HECTD2、PPP1R3C、LOC100507633、TNKS2、FGFBP3、BTAF1、CPEB3、MARCH5、MARK2P9、IDE、KIF11、HHEX、EXOC6、CYP26C1、CYP26A1、MYOF、CEP55、FFAR4、RBP4、PDE6C、FRA10AC1、LGI1、SLC35G1、PIPSL、PLCE1、LOC100128054、NOC3L、TBC1D12、HELLS、CYP2C18、CYP2C19、CYP2C9、CYP2C8、C10orf129、PDLIM1、SORBS1、ALDH18A1、TCTN3、ENTPD1、LOC728558、C10orf131、CC2D2B、CCNJ、MIR3157、ZNF518A、BLNK、DNTT、OPALIN、TLL2、TM9SF3、PIK3AP1、RPL13AP5、MIR607、LCOR、C10orf12、SLIT1、LOC100505540、ARHGAP19-SLIT1、ARHGAP19、FRAT1、FRAT2、RRP12、PGAM1、EXOSC1、ZDHHC16、MMS19、UBTD1、ANKRD2、HOGA1、C10orf62、MORN4、PI4K2A、AVPI1、MARVELD1、ZFYVE27、SFRP5、LOC100505561、GOLGA7B、CRTAC1、R3HCC1L、LOXL4、PYROXD2、MIR1287、HPS1、MIR4685、HPSE2、CNNM1、GOT1、NKX2-3、SLC25A28、ENTPD7、COX15、CUTC、ABCC2、DNMBP、DNMBP-AS1、CPN1、ERLIN1、CHUK、CWF19L1、SNORA12、BLOC1S2、PKD2L1、SCD、LINC00263、WNT8B、SEC31B、NDUFB8、HIF1AN、PAX2, FAM178A, SEMA4G, MIR608, MRPL43, C10orf2, LZTS2, PDZD7, SFXN3, KAZALD1, TLX1NB, TLX1, LBX1, FLJ41350, BTRC, POLL, DPCD, MIR3158-1, MIR3158-2, FBXW4, FGF8, NPM3, MGEA5, LOC100289509, KCNIP2, C10orf76, HPS6, LDB1, PPRC1, NOLC1, ELOVL3, PITX3, GBF1, NFKB2, PSD, FBXL15, CUEDC2, MIR146B, LOC100505761, C10orf95, TMEM180, ACTR1A, SUFU, TRIM8, ARL3, SFXN2, WBP1L, CYP17A1, CYP17A1-AS1, C10orf32, C10orf32-AS3MT, AS3MT, CNNM2, NT5C2, LOC729020, INA、PCGF6、TAF5、USMG5、MIR1307、PDCD11、CALHM2、CALHM1、CALHM3、NEURL、SH3PXD2A、LOC100505839、OBFC1、SLK、COL17A1、MIR936、SFR1、WDR96、MIR6 09、GSTO1、MIR4482-1、GSTO2、ITPRIP、LOC100505869、CCDC147、SORCS3、SORCS1、XPNPEP1、LOC100505933、ADD3、MXI1、SMNDC1、DUSP5、SMC3、RBM20、LOC 282997、PDCD4、MIR4680、BBIP1、SHOC2、RPL13AP6、MIR548E、ADRA2A、GPAM、TECTB、GUCY2GP、ACSL5、ZDHHC6、VTI1A、MIR4295、TCF7L2、HABP2、NRAP、CASP 7、PLEKHS1、MIR4483、DCLRE1A、NHLRC2、ADRB1、C10orf118、MIR2110、TDRD1、VWA2、AFAP1L2、ABLIM1、FAM160B1、TRUB1、ATRNL1、GFRA1、CCDC172、PNLIPR P3、PNLIP、PNLIPRP1、PNLIPRP2、C10orf82、HSPA12A、ENO4、KIAA1598、VAX1、MIR3663、KCNK18、SLC18A2、PDZD8、EMX2OS、EMX2、LOC100996346、RAB11FIP 2、CASC2、FAM204A、LOC100506126、PRLHR、CACUL1、NANOS1、EIF3A、SNORA19、FAM45A、SFXN4、PRDX3、GRK5、MIR4681、RGS10、TIAL1、BAG3、INPP5F、MCMBPSEC23IP、MIR4682、PPAPDC1A、WDR11-AS1、WDR11、FGFR2、ATE1、LOC1001308 87、NSMCE4A、TACC2、BTBD16、PLEKHA1、MIR3941、ARMS2、HTRA1、DMBT1、C10o rf120、FLJ46361、CUZD1、FAM24B-CUZD1、FAM24B、LOC399815、FAM24A、C10o rf88、PSTK、IKZF5、ACADSB、HMX3、HMX2、BUB3、GPR26、CPXM2、CHST15、OAT、NK X1-2、LHPP、LOC100506255、FAM53B、METTL10、FAM175B、ZRANB1、CTBP2、MIR 4296、LOC100169752、TEX36、LOC283038、FLJ37035、C10orf137、MMP21、UROS 、MIR4484、BCCIP、DHX32、FANK1、ADAM12、C10orf90、LOC728065、DOCK1、FAM 196A、NPS、FOXI2、CLRN3、PTPRE、MKI67、MGMT、EBF3、MIR4297、LOC387723、CT AGE7P、GLRX3、MIR378C、TCERG1L、FLJ46300、PPP2R2D、BNIP3、JAKMIP3、DPY SL4、STK32C、LOC100506057、LRRC27、PWWP2B、C10orf91、INPP5A、NKX6-2、T TC40、LOC100289424、LOC399829、GPR123、KNDC1、UTF1、VENTX、MIR202、ADA M8、TUBGCP2、ZNF511、CALY、PRAP1、FUOM、ECHS1、MIR3944、PAOX、MTG1、SPRN、 LOC619207、CYP2E1、SYCE1、SPRNP1、FRG2B、LOC100133161、SCGB1C1、ODF3、 BET1L、RIC8A、SIRT3、PSMD13、NLRP6、ATHL1、IFITM5、IFITM2、IFITM1、IFITM 3, B4GALNT4, PKP3, SIGIRR, ANO9, PTDSS2, RNH1, HRAS, LRRC56, C11orf35, LOC692247, RASSF7, MIR210HG, MIR210, LOC143666, PHRF1, IRF7, CDHR5, SCTDRD4、DEAF1、TMEM80、EPS8L2、TALDO1、PDDC1、LOC100506518、NS3BP、CEND1、SLC25A22、PIDD、RPLP2、SNORA52、PNPLA2、EFCAB4A、CD151、POLR2L、TSPAN4、 CHID1、AP2A2、MUC6、MUC2、MUC5B、TOLLIP、LOC255512、BRSK2、MOB2、DUSP8、LOC338651、KRTAP5-1、KRTAP5-2、KRTAP5-3、KRTAP5-4、KRTAP5-5、FAM99A、FAM99B、LOC100505570、KRTAP5-6、IFITM10、CTSD、SYT8、TNNI2、LSP1、MIR4298、TNNT3、MRPL23、MRPL23-AS1、H19、MIR675、INS-IGF2、IGF2、MIR483、IGF2-AS、INS、TH、MIR4686、ASCL2、C11orf21、TSPAN32、CD81、TSSC4、TRPM5、KCNQ1、KCNQ1OT1、KCNQ1DN、CDKN1C、SLC22A18AS、SLC22A18、PHLDA2、NAP1L4、SNORA54、LOC100505870、CARS、OSBPL5、MRGPRG、MRGPRG-AS1、MRGPRE、ZNF195、LOC650368、OR7E12P、TRPC2、ART5、ART1、CHRNA10、NUP98、PGAP2、RHOG、STIM1、MIR4687、RRM1、LOC100506082、OR52B4、TRIM21、OR52K2、OR52K1、OR52M1、C11orf40、OR52I2、OR52I1、TRIM68、OR51D1、OR51E1、OR51E2、OR51F1、OR52R1、OR51F2、OR51S1、OR51T1、OR51A7、OR51G2、OR51G1、OR51A4、OR51A2、MMP26、OR51L1、OR52J3、OR52E2、LOC100506101、OR52A5、OR52A1、OR51V1、HBB、HBD、HBBP1、HBG1、HBG2、HBE1、OR51B4、OR51B2、OR51B5、OR51B6、OR51M1、OR51Q1、OR51I1、OR51I2、OR52D1、UBQLN3、UBQLNL、OR52H1、OR52B6、TRIM6、TRIM6-TRIM34、TRIM34、TRIM5、TRIM22、OR56B1、OR52N4、OR52N5、OR52N1、OR52N2、OR52E6、OR52E8、OR52E4、OR56A3、OR56A5、OR52L1、OR56A4、OR56A1、OR56B4, OR52B2, OR52W1, C11orf42, FAM160A2, CNGA4, CCKBR, PRKCDBP, SMP D1, APBB1, HPX, TRIM3, ARFIP2, FXC1, DNHD1, RRP8, ILK, TAF10, TPP1, DCHS1. MRPL17, GVINP1, OR2AG2, OR2AG1, OR6A2, OR10A5, OR10A2, OR10A4, OR2D2, O R2D3, ZNF215, ZNF214, NLRP14, RBMXL2, LOC100506238, MIR302E, SYT9, LOC1 00506258. OLFML1, PPFIBP2, CYB5R2, OVCH2, OR5P2, OR5P3, OR5E1P, LOC283 299 OR10A6 OR10A3 NLRP10 EIF3F TUB RIC3 LMO1 STK33 TRIM66 RPL27 A. SNORA3, SNORA45, ST5, AKIP1, C11orf16, ASCL3, TMEM9B, NRIP3, SCUBE2. MIR5691, KRT8P41, DENND5A, TMEM41B, IPO7, SNORA23, LOC644656, ZNF143, W.S EE1, SWAP70, LOC440028, SBF2-AS1, SBF2, ADM, AMPD3, MTRNR2L8, MIR4485. RNF141, MRVI1-AS1, LYVE1, MRVI1, CTR9, EIF4G2, SNORD97, ZBED5, LOC72901 3. GALNTL4, CSNK2A1P, MIR4299, USP47, DKK3, MICAL2, MICALCL, PARVA, TEA D1, LOC100506305, LOC100506352, RASSF10, ARNTL, LOC100996618, BTBD10 PTH, FAR1, SPON1, RRAS2, COPB1, PSMA1, PDE3B, CYP2R1, CALCA, CALCB, INSC SOX6, C11orf58, PLEKHA7, OR7E14P, RPS13, SNORD14A, SNORD14B, PIK3C2A. NUCB2, NCR3LG1, KCNJ11, ABCC8, USH1C, OTOG, MYOD1, KCNC1, SERGEF, TPH1. SAAL1, SAA3P, MRGPRX3, MRGPRX4, LOC494141, SAA4, SAA2-SAA4, SAA2, SAA1HPS5、GTF2H1、MIR3159、LDHA、LDHC、LDHAL6A、TSG101、UEVLD、SPTY2D1-AS1、SPTY2D1、TMEM86A、IGSF22、PTPN5、MRGPRX1、MRGPRX2、ZDHHC13、 CSRP3、E2F8、NAV2、NAV2-AS5、NAV2-AS4、MIR4486、LOC100126784、MIR4694、DBX1、HTATIP2、PRMT3、SLC6A5、NELL1、ANO5、SLC17A6、FANCF、GAS2、SVIP、LOC100500938、LUZP2、ANO3、MUC15、SLC5A12、FIBIN、BBOX1、CCDC34、LGR4、LIN7C、BDNF-AS、BDNF、KIF18A、MIR610、METTL15、KCNA4、FSHB、ARL14EP、MPPED2、DCDC5、LOC100508736、DCDC1、DNAJC24、IMMP1L、ELP4、PAX6、DKFZp686K1684、LOC100506675、RCN1、WT1、WT1-AS、EIF3M、CCDC73、PRRG4、QSER1、DEPDC7、TCP11L1、LINC00294、CSTF3、LOC338739、HIPK3、KIAA1549L、C11orf91、CD59、FBXO3、LOC100507109、LMO2、CAPRIN1、NAT10、ABTB2、CAT、ELF5、EHF、APIP、PDHX、MIR1343、LOC100507144、CD44、SLC1A2、PAMR1、FJX1、TRIM44、LDLRAD3、MIR3973、COMMD9、PRR5L、TRAF6、RAG1、RAG2、C11orf74、LRRC4C、LOC100507205、HNRNPKP3、API5、TTC17、MIR670、LOC100507261、LOC100131381、MIR129-2、HSD17B12、ALKBH3、SEC14L1P1、LOC100507300、C11orf96、ACCSL、ACCS、EXT2、ALX4、CD82、TSPAN18、TP53I11、LOC221122、PRDM11、SYT13、CHST1、LOC100507384、DKFZp779M0652、SLC35C1、CRY2、MAPK8IP1、C11orf94、PEX16、GYLTL1B、PHF21A、CREB3L1、DGKZ、MIR4688、MDK、CHRM4、AMBRA1、MIR3160-1、MIR3160-2、HARBI1、ATG13、ARHGAP1、ZNF408、F2、CKAP5、MIR5582、SNORD67、LRP4-AS1、LRP4、C11orf49、ARFGAP2、PACSIN3、DDB2、ACP2、NR1H3、MADD、MYBPC3、SPI1、LOC100507417、MIR4487、SLC39A13、PSMC3、RAPSN、CEL F1、PTPMT1、KBTBD4、NDUFS3、FAM180B、C1QTNF4、MTCH2、AGBL2、FNBP4、NUP160、PTPRJ、MIR3161、OR4B1、OR4X2、OR4X1、OR4S1、OR4C3、OR4A47、TRIM51GP、 TRIM49B、TRIM64C、FOLH1、LOC440040、OR4C13、OR4C12、LOC441601、LOC646813、OR4A5、OR4C46、TRIM48、TRIM51HP、OR4A16、OR4A15、OR4C15、OR4C16 4C11、OR4P4、OR4S2、OR4C6、OR5D13、OR5D14、OR5L1、OR5D18、OR5L2、OR5D16、TRIM51、OR5W2、OR5I1、OR10AG1、OR7E5P、OR5F1、OR5AS1、OR8I2、OR8H2、OR8H2 H3、OR8J3、OR8K5、OR5J2、OR5T2、OR5T3、OR5T1、OR8H1、OR8K3、OR8K1、OR8J1、OR8U1、OR5R1、OR5M9、OR5M3、OR5M8、OR5M11、OR5M10、OR5M1、OR5AP2、OR5AR 1、OR9G1、OR9G4、OR5AK2、OR5AK4P、LRRC55、APLNR、TNKS1BP1、SSRP1、P2RX3、PRG3、PRG2、SLC43A3、RTN4RL2、SLC43A1、TIMM10、SMTNL1、UBE2L6、SERPING 1、MIR130A、YPEL4、CLP1、ZDHHC5、MED19、TMX2、TMX2-CTNND1、C11orf31、BTBD18、CTNND1、OR9Q1、OR6Q1、OR9I1、OR9Q2、OR1S2、OR1S1、OR10Q1、OR10W1 R5B17、OR5B3、OR5B2、OR5B12、OR5B21、LPXN、ZFP91-CNTF、ZFP91、CNTF、GLYAT、GLYATL2、LOC100287413、GLYATL1、LOC283194、FAM111B、FAM111A、DTX4、MPEG1、OR5AN1、OR5A2、OR5A1、OR4D6、OR4D10、OR4D11、OR4D9、OSBP、MIR3162、PATL1、OR10V1、OR10V2P、STX3、MRPL16、GIF、TCN1、PLAC1L、MS4A3、MS4A2、 MS4A6A、MS4A4E、MS4A4A、MS4A6E、MS4A7、MS4A14、MS4A5、MS4A1、MS4A12、MS 4A13、LINC00301、MS4A8B、MS4A15、MS4A10、CCDC86、PTGDR2、ZP1、PRPF19、TM EM109、TMEM132A、SLC15A3、CD6、CD5、VPS37C、PGA3、PGA4、PGA5、VWCE、DDB1 、DAK、CYBASC3、TMEM138、TMEM216、CPSF7、SDHAF2、PPP1R32、MIR4488、LRRC1 0B、SYT7、RPLP0P2、DAGLA、C11orf9、DKFZP434K028、LOC100129473、C11orf 10、MIR611、FEN1、FADS1、MIR1908、FADS2、FADS3、RAB3IL1、BEST1、FTH1、LOC 100507521、INCENP、SCGB1D1、SCGB2A1、SCGB1D2、SCGB2A2、SCGB1D4、ASRGL 1、SCGB1A1、AHNAK、EEF1G、TUT1、MTA2、EML3、ROM1、B3GAT3、GANAB、INTS5、C1 1orf48、METTL12、SNORA57、C11orf83、UBXN1、LRRN4CL、HNRNPUL2-BSCL2、B SCL2、GNG3、HNRNPUL2、TTC9C、ZBTB3、POLR2G、TAF6L、TMEM179B、TMEM223、NX F1、STX5、WDR74、RNU2-2、SNHG1、SNORD22、SNORD31、SNORD30、SNORD29、SNO RD28、SNORD27、SNORD26、SNORD25、SLC3A2、CHRM1、SLC22A6、SLC22A8、SLC22 A24, SLC22A25, SLC22A10, SLC22A9, HRASLS5, LGALS12, RARRES3, HRASLS2, PLA2G16, ATL3, RTN3, C11orf95, C11orf84, MARK2, RCOR2, NAA40, RNU6-45, C OX8A、OTUB1、MACROD1、FLRT1、STIP1、FERMT3、TRPT1、NUDT22、DNAJC4、VEGF B、FKBP2、PPP1R14B、PLCB3、BAD、GPR137、KCNK4、C11orf20、ESRRA、TRMT112、PRDX5, CCDC88B, RPS6KA4, MIR1237, LOC100996455, SLC22A11, SLC22A12, N.S RXN2, RASGRP2, PYGM, SF1, MAP4K2, MEN1, CDC42BPG, EHD1, MIR192, MIR194- 2, ATG2A, PPP2R5B, GPHA2, C11orf85, BATF2, ARL2-SNX15, ARL2, SNX15, SAC 3D1, NAALADL1, CDCA5, ZFPL1, LOC100130348, VPS51, TM7SF2, ZNHIT2, FAU, M RPL49, SYVN1, SPDYC, CAPN1, SLC22A20, POLA2, CDC42EP2, DPF2, TIGD3, SLC 25A45, FRMD8, NEAT1, MIR612, MALAT1, SCYL1, LTBP3, LOC254100, SSSCA1, FA M89B, EHBP1L1, KCNK7, MAP3K11, PCNXL3, MIR4690, SIPA1, MIR4489, RELA AT5, RNASEH2C, AP5B1, OVOL1, SNX32, CFL1, MUS81, EFEMP2, CTSW, FIBP, CCDC 85B, FOSL1, C11orf68, DRAP1, TSGA10IP, SART1, EIF1AD, BANF1, CST6, CATS PER1, GAL3ST3, SF3B2, PACS1, KLC2, RAB1B, CNIH2, YIF1A, TMEM151A, CD248 RIN1, BRMS1, B3GNT1, SLC29A2, LOC100505504, NPAS4, MRPL11, PELI3, DPP 3. BBS1, ZDHHC24, ACTN3, CTSF, CCDC87, CCS, RBM14, RBM14-RBM4, RBM4, RBM4 B, SPTBN2, C11orf80, RCE1, PC, LRFN4, MIR3163, C11orf86, SYT12, RHOD, KD M2A, ADRBK1, ANKRD13D, SSH3, LOC100130987, POLD4, CLCF1, RAD9A, PPP1CA. TBC1D10C, CARNS1, RPS6KB2, PTPRCAP, CORO1B, GPR152, CABP4, TMEM134, AI P. PITPNM1, CDK2AP2, CABP2, GSTP1, NDUFV1, LOC100996505, DOC2GP, NUDT8.TBX10, ACY3, ALDH3B2, FAM86C2P, RNU6-46, UNC93B1, ALDH3B1, NDUFS8, MIR4691, TCIRG1, CHKA, SUV420H1, C11orf24, LRP5, PPP6R3, GAL, MTL5, CPT1A, MRPL21 IGHMBP2、MRGPRD、MRGPRF、TPCN2、MIR3164、MYEOV、LOC100505834、LOC1009 96515、CCND1、ORAOV1、FGF19、FGF4、FGF3、LOC100127946、ANO1-AS2、ANO1、 FADD, PPPFIA1, MIR548K, CTTN, SHANK2, SHANK2-AS1, SHANK2-AS3, MIR3664, FLJ42102, DHCR7, NADSYN1, KRTAP5-7, KRTAP5-8, KRTAP5-9, KRTAP5-10, KRT AP5-11、FAM86C1、ZNF705E、DEFB108B、LOC100133315、LOC100129216、RNF1 21、IL18BP、NUMA1、MIR3165、LRTOMT、LAMTOR1、ANAPC15、FOLR3、FOLR1、FOL R2、INPPL1、PHOX2A、CLPB、PDE2A、MIR139、ARAP1、ARAP1-AS2、STARD10、MIR 4692、ATG16L2、FCHSD2、P2RY2、P2RY6、LOC100287837、ARHGEF17、RELT、FAM1 68A、PLEKHB1、RAB6A、MRPL48、COA4、PAAF1、DNAJB13、UCP2、UCP3、C2CD3、PP ME1、P4HA3、PGM2L1、MIR548AL、KCNE3、LIPT2、LOC100287896、POLD3、CHRDL 2、MIR4696、RNF169、XRRA1、SPCS2、NEU3、OR2AT4、SLCO2B1、TPBGL、ARRB1、M IR326、RPS3、SNORD15A、SNORD15B、KLHL35、GDPD5、SERPINH1、MAP6、MOGAT2、 LOC283214、DGAT2、LOC100506113、UVRAG、WNT11、PRKRIR、LOC100996578、C 11orf30、LRRC32、GUCY2EP、TSKU、ACER3、B3GNT6、CAPN5、OMP、MYO7A、GDPD4 、PAK1、AQP11、CLNS1A、RSF1、AAMDC、INTS4、NDUFC2-KCTD14、KCTD14、THRSP 、NDUFC2、ALG8、LOC100289388、KCTD21、USP35、GAB2、NARS2、TENM4、MIR708、MIR5579、MIR4300、FAM181B、PRCP、C11orf82、RAB30、SNORA70E、LOC100506 233、PCF11、LOC100506282、ANKRD42、CCDC90B、DLG2、TMEM126B、TMEM126A、 CREBZF、CCDC89、SYTL2、CCDC83、PICALM、EED、C11orf73、CCDC81、ME3、PRSS 23、OR7E2P、FZD4、LOC100506368、TMEM135、RAB38、MIR3166、CTSC、GRM5-AS 1, GRM5, RNU6-16, TYR, NOX4, FOLH1B, TRIM77P, TRIM49, TRIM64B, TRIM49DP, TRIM49L1, TRIM64, TRIM51EP, TRIM53AP, TRIM49C, UBTFL1, NAALAD2, CHOR DC1、MIR4490、MIR1261、FAT3、MTNR1B、SLC36A4、CCDC67、C11orf75、KIAA17 31、SCARNA9、SNORA25、SNORA32、SNORD6、SNORA1、SNORA8、SNORD5、SNORA18、 MIR1304、SNORA40、TAF1D、C11orf54、MED17、VSTM5、HEPHL1、PANX1、FOLR4、 GPR83、MRE11A、MIR548L、ANKRD49、LOC643037、FUT4、PIWIL4、AMOTL1、CWC1 5、KDM4D、KDM4E、SRSF8、ENDOD1、SESN3、LOC100129203、FAM76B、CEP57、MTM R2、MAML2、LOC100131541、MIR1260B、CCDC82、JRKL、JRKL-AS1、CNTN5、ARHG AP42、TMEM133、PGR、LOC101054525、TRPC6、MIR3920、ANGPTL5、KIAA1377、C 11orf70、YAP1、BIRC3、BIRC2、TMEM123、MMP7、MMP20、MMP27、MMP8、MMP10、W TAPP1, MMP1, MMP3, MMP12, MMP13, DCUN1D5, DYNC2H1, MIR4693, PDGFD, DDI1, CASP12, LOC643733, CASP4, CASP5, CASP1, CARD16, CARD17, CARD18, GRIA4MSANTD4、KBTBD3、AASDHPPT、GUCY1A2、CWF19L2、ALKBH8、ELMOD1、LOC643923、SLN、SLC35F2、RAB39A、CUL5、ACAT1、NPAT、ATM、C11orf65、KDELC2、EXPH5、DDX10、 SKCG-1、C11orf87、ZC3H12C、RDX、FDX1、ARHGAP20、C11orf53、C11orf92、C11orf93、MIR4491、POU2AF1、LOC100132078、LOC644277、BTG4、MIR34B、MIR34 C, C11orf88, LAYN, SIK2, PPP2R1B, ALG9, FDXACB1, C11orf1, CRYAB, HSPB2, HSPB2-C11orf52, C11orf52, DIXDC1, DLAT, PIH1D2, C11orf57, TIMM8B, SDHD 、IL18、TEX12、BCO2、PTS、C11orf34、NCAM1、LOC100288346、TTC12、ANKK1、DRD2、MIR4301、TMPRSS5、ZW10、CLDN25、USP28、HTR3B、HTR3A、ZBTB16、NNMT、C 11orf71、RBM7、REXO2、NXPE1、NXPE4、NXPE2、CADM1、LOC283143、BUD13、ZNF259、APOA5、APOA4、APOC3、APOA1、SIK3、PAFAH1B2、SIDT2、LOC100652768、TA GLN, PCSK7, RNF214, BACE1, BACE1-AS, CEP164, DSCAML1, FXYD2, FXYD6-FXYD2, FXYD6, TMPRSS13, IL10RA, TMPRSS4-AS1, TMPRSS4, SCN4B, SCN2B, AMICA1 、MPZL3、MPZL2、CD3E、CD3D、CD3G、UBE4A、LOC100131626、ATP5L、MGC13053、MLL、TTC36、TMEM25、IFT46、ARCN1、PHLDB1、TREH、DDX6、CXCR5、BCL9L、MIR44 92, UPK2, FOXR1, CCDC84, RPL23AP64, RPS25, TRAPPC4, MIR3656, SLC37A4, HYOU1, VPS11, HMBS, H2AFX, DPAGT1, C2CD2L, HINFP, ABCG4, NLRX1, PDZD3, CCD C153、CBL、MCAM、RNF26、C1QTNF5、MFRP、USP2、LOC100499227、THY1、PVRL1、LOC100507077、TRIM29、OAF、POU2F3、LOC649133、TMEM136、ARHGEF12、GRIK4、TBCEL、TECTA、SC5DL、SORL1、LOC100507165、LOC100507145、MIR100HG、MI R125B1、BLID、MIRLET7A2、MIR100、UBASH3B、CRTAM、C11orf63、BSX、LOC341 056、HSPA8、SNORD14E、SNORD14D、SNORD14C、CLMP、MIR4493、LOC100128242 、GRAMD1B、SCN3B、ZNF202、OR6X1、OR6M1、TMEM225、OR8D4、OR4D5、OR6T1、OR 10S1、OR10G4、OR10G9、OR10G8、OR10G7、VWA5A、OR8G2、OR8G1、OR8G5、OR8D 1、OR8D2、OR8B2、OR8B3、OR8B4、OR8B8、OR8B12、OR8A1、PANX3、TBRG1、SIAE、 SPA17、NRGN、VSIG2、ESAM、MSANTD2、LOC100130428、ROBO3、ROBO4、HEPACAM 、HEPN1、CCDC15、SLC37A2、TMEM218、PKNOX2、FEZ1、MGC39545、EI24、STT3A、 CHEK1、ACRV1、PATE1、PATE2、PATE3、PATE4、HYLS1、PUS3、DDX25、LOC33866 7、CDON、RPUSD4、FAM118B、SRPR、FOXRED1、TIRAP、DCPS、FLJ39051、ST3GAL4 KIRREL3, KIRREL3-AS2, MIR3167, KIRREL3-AS3, ETS1, FLI1, FLI1-AS1, KCNJ1, KCNJ5, C11orf45, TP53AIP1, ARHGAP32, BARX2, TMEM45B, NFRKB, PRDM1 0、LINC00167、APLP2、ST14、ZBTB44、LOC100996646、ADAMTS8、ADAMTS15、C1 1orf44、LOC100507431、SNX19、NTM、C11orf39、OPCML、SPATA19、LOC283174 、MIR4697、LOC646543、IGSF9B、LOC100128239、JAM3、NCAPD3、VPS26B、THYN1、ACAD8、GLB1L3、GLB1L2、B3GAT1、LOC283177、LOC729305、LOC100507548、LOC100288778、FAM138D、IQSEC3、LOC574538、SLC6A12、SLC6A13、KDM5A、CCDC77、B4GALNT3、NINJ2、WNK1、RAD52、LOC100130219、ERC1、LOC100292680、FBXL14、WNT5B、MIR3649、ADIPOR2、 CACNA2D4、LRTM2、LOC100271702、DCP1B、CACNA1C、CACNA1C-AS4、CACNA1C-IT3、CACNA1C-AS1、LOC283440、FKBP4、ITFG2、NRIP2、LOC100507424、LOC100996378、FOXM1、RHNO1、TULP3、TEAD4、TSPAN9、PRMT8、LOC100129223、LOC100128816、EFCAB4B、PARP11、LOC100507511、CCND2、C12orf5、FGF23、FGF6、C12orf4、RAD51AP1、DYRK4、AKAP3、NDUFA9、GALNT8、KCNA6、KCNA1、LOC100507560、KCNA5、NTF3、ANO2、VWF、CD9、PLEKHG6、TNFRSF1A、SCNN1A、LTBR、CD27-AS1、CD27、TAPBPL、VAMP1、MRPL51、NCAPD2、SCARNA10、GAPDH、LOC100996356、IFFO1、NOP2、CHD4、LOC100127974、SCARNA11、LPAR5、ACRBP、ING4、ZNF384、PIANP、COPS7A、MLF2、PTMS、LAG3、CD4、GPR162、LEPREL2、GNB3、CDCA3、USP5、TPI1、SPSB2、RPL13P5、DSTNP2、LRRC23、ENO2、ATN1、RNU7-1、C12orf57、PTPN6、MIR200C、MIR141、PHB2、SCARNA12、EMG1、LPCAT3、C1S、C1R、C1RL、C1RL-AS1、RBP5、CLSTN3、PEX5、ACSM4、CD163L1、CD163、APOBEC1、GDF3、DPPA3、CLEC4C、NANOGNB、NANOG、SLC2A14、SLC2A3、FOXJ2、C3AR1、NECAP1、CLEC4A、POU5F1P3、ZNF705A、FAM66C、FAM90A1、FAM86FP、LOC389634、CLEC6A、CLEC4D、CLEC4E、AICDA、MFAP5、RIMKLB、A2ML1、PHC1、M6PR、KLRG1、LINC00612、A2M-AS1、A2M、PZP、A2MP1、MIR1244-3、LOC100499405、LOC642846、LOC100653000、LOC728715、DDX12P、OVOS、KLRB1、LOC374443、CLEC2D、CLECL1、CD69、KLRF1、CLEC2B、KLRF2、CLEC2A、CLEC12A、CLEC1B、CLEC12B、CLEC9A、CLEC1A、CLEC1 7A、OLR1、TMEM52B、GABARAPL1、KLRD1、KLRC4-KLRK1、KLRK1、KLRC4、KLRC3、KLRC2、KLRC1、KLRAP1、MAGOHB、STYK1、CSDA、LOC100506226、TAS2R7、TAS2R8 、TAS2R9、TAS2R10、PRH1-PRR4、PRR4、PRH1、TAS2R13、PRH2、TAS2R14、TAS2R50、TAS2R20、TAS2R19、TAS2R31、TAS2R46、TAS2R43、TAS2R30、TAS2R42、PRB3 、PRB4、PRB1、PRB2、LOC338817、ETV6、BCL2L14、LOC100506248、LRP6、MANSC1、LOH12CR2、LOH12CR1、DUSP16、CREBL2、GPR19、CDKN1B、APOLD1、MIR613、DD X47、RPL13AP20、GPRC5A、MIR614、GPRC5D、HEBP1、LOC100506314、HTR7P1、KIAA1467、GSG1、EMP1、C12orf36、GRIN2B、ATF7IP、PLBD1、GUCY2C、HIST4H4、H 2AFJ、WBP11、C12orf60、C12orf69、ART4、MGP、ERP27、ARHGDIB、PDE6H、RERG、PTPRO、EPS8、STRAP、DERA、SLC15A5、MGST1、LMO3、SKP1P2、MIR3974、RERGL、 PIK3C2G, PLCZ1, CAPZA3, PLEKHA5, AEBP2, LOC100506393, PDE3A, SLCO1C1, SLCO1B3, SLCO1B7, SLCO1B1, SLCO1A2, IAPP, PYROXD1, RECQL, GOLT1B, C12orf39, GYS2, LDHB, KCNJ8, ABCC9, CMAS, ST8SIA1, KIAA0528, LOC100996472, ETNK1, SOX5, MIR920, LINC00477, BCAT1, C12orf77, LOC645177, LRMP, CASC1,LYRM5, KRAS, IFLTD1, MIR4302, LOC100506451, RASSF8, LOC100996477, BHLHE41, SSPN, ITPR2, ASUN, FGFR1OP2, TM7SF3, MED21, C12orf71, STK38L, ARNTL2, C12orf70 PPFIBP1, REP15, MRPS35, MANSC4, KLHDC5, PTHLH, CCDC91, FAR2, LOC100506606, ERGIC2, LOC101055625, OVCH1, TMTC1, IPO8, CAPRIN2, LOC100287314 TSPAN11、DDX11-AS1、DDX11、FAM60A、FLJ13224、DENND5B、DENND5B-AS1、ME TTL20、AMN1、H3F3C、KIAA1551、BICD1、FGD4、DNM1L、YARS2、PKP2、SYT10、ALG 10、ALG10B、CPNE8、KIF21A、ABCD2、C12orf40、SLC2A13、LRRK2、MUC19、CNTN 1、PDZRN4、GXYLT1、YAF2、ZCRB1、PPHLN1、PRICKLE1、LOC100506684、ADAMTS2 0、PUS7L、IRAK4、TWF1、TMEM117、NELL2、DBX2、RACGAP1P、PLEKHA8P1、ANO6、 LOC400027、ARID2、SCAF11、SLC38A1、SLC38A2、LOC100288798、SLC38A4、AMI GO2、MIR4698、PCED1B-AS1、PCED1B、MIR4494、RPAP3、ENDOU、RAPGEF3、SLC4 8A1、HDAC7、VDR、TMEM106C、COL2A1、SENP1、PFKM、ASB8、C12orf68、OR10AD1、 H1FNT、ZNF641、LOC100505923、ANP32D、C12orf54、OR8S1、LALBA、KANSL2、S NORA34、SNORA2A、SNORA2B、CCNT1、LOC255411、ADCY6、MIR4701、LOC1005061 25、CACNB3、DDX23、RND1、CCDC65、FKBP11、ARF3、WNT10B、WNT1、DDN、PRKAG1 、MLL2、RHEBL1、DHH、LMBR1L、TUBA1B、TUBA1A、LOC100293962、TUBA1C、PRPH、 TROAP、C1QL4、DNAJC22、SPATS2、LOC100335030、KCNH3、MCRS1、FAM186B、PR PF40B、FMNL3、TMBIM6、NCKAP5L、BCDIN3D-AS1、BCDIN3D、FAIM2、LOC283332、AQP2, AQP5, AQP6, RACGAP1, ASIC1, SMARCD1, GPD1, COX14, CERS5, LIMA1, MIR1293, FAM186A, LARP4, DIP2B, ATF1, TMPRSS12, METTL7A, HIGD1C, SLC11A 2、LETMD1、CSRNP2、TFCP2、POU6F1、DAZAP2、SMAGP、BIN2、CELA1、GALNT6、SLC4A8、SCN8A、FIGNL2、LOC728503、ANKRD33、ACVRL1、ACVR1B、GRASP、NR4A1、 C12orf44、KRT80、LOC283403、LINC00592、KRT7、KRT81、KRT86、KRT83、KRT85、KRT84、KRT82、KRT75、KRT6B、KRT6C、KRT6A、KRT5、KRT71、KRT74、KRT72、K RT73, KRT2, KRT1, KRT77, KRT76, KRT3, KRT4, KRT79, KRT78, KRT8, KRT18, EIF4B, LOC283335, TENC1, SPRYD3, IGFBP6, SOAT2, CSAD, ZNF740, ITGB7, RARG ,MFSD5,ESPL1,PFDN5,C12orf10,AAAS,SP7,SP1,AMHR2,PRR13,PCBP2,MAP3K12,TARBP2,NPFF,ATF7,LOC100652999,ATP5G2,CALCOCO1,HOXC-AS5,HOXC13,HOXC12,HOTAIR,HOXC11,HOXC10,MIR196A2,HOXC9,HOXC8,HOXC5,HOXC6,HOXC4,MIR615,FLJ12825,LOC100240735,LOC100240734,LOC400043, SMUG1, CBX5, MIR3198-2, HNRNPA1, NFE2, COPZ1, MIR148B, GPR84, ZNF385A, ITGA5, GTSF1, NCKAP1L, PDE1B, PPP1R1A, GLYCAM1, LACRT, DCD, MUCL1, TESP A1.BLOC1S1-RDH5、BLOC1S1、RDH5、CD63、GDF11、SARNP、ORMDL2、DNAJC14、TMEM198B、MMP19、WIBG、DGKA、PMEL、CDK2、RAB5B、SUOX、IKZF4、RPS26、ERBB3、 PA2G4、RPL41、ZC3H10、ESYT1、MYL6B、MYL6、SMARCC2、RNF41、NABP2、SLC39A5、ANKRD52、COQ10A、CS、CNPY2、PAN2、IL23A、STAT2、APOF、TIMELESS、MIP、SPRYD4、GLS2、RBMS2、BAZ2A、ATP5B、SNORD59B、SNORD59A、PTGES3、NACA、PRIM1、HSD17B6、SDR9C7、RDH16、GPR182、HBCBP、ZBTB39、TAC3、MYO1A、TMEM194A、NAB2、STAT6、LRP1、MIR1228、NXPH4、SHMT2、NDUFA4L2、STAC3、R3HDM2、INHBC、INHBE、GLI1、ARHGAP9、MARS、DDIT3、MIR616、MBD6、DCTN2、KIF5A、PIP4K2C、DTX3、ARHGEF25、SLC26A10、B4GALNT1、OS9、AGAP2、LOC100130776、TSPAN31、CDK4、MARCH9、CYP27B1、METTL1、METTL21B、TSFM、AVIL、CTDSP2、MIR26A2、LOC100506844、XRCC6BP1、LOC100506869、LRIG3、SLC16A7、FAM19A2、USP15、MON2、C12orf61、MIRLET7I、PPM1H、AVPR1A、DPY19L2、TMEM5、SRGAP1、C12orf66、C12orf56、XPOT、TBK1、RASSF3、MIR548Z、MIR548C、GNS、TBC1D30、FLJ41278、WIF1、LEMD3、MSRB3、LOC100507065、RPSAP52、HMGA2、LLPH、TMBIM4、IRAK3、HELB、GRIP1、CAND1、LOC100507175、DYRK2、IFNG、IL26、IL22、MDM1、LOC100507195、RAP1B、SNORA70G、LOC100507250、NUP107、SLC35E3、MDM2、CPM、CPSF6、MIR1279、LYZ、YEATS4、FRS2、MIR3913-1、MIR3913-2、CCT2、LRRC10、BEST3、RAB3IP、C12orf28、CNOT2、KCNMB4、PTPRB、LOC100507330、PTPRR、TSPAN8、LGR5、ZFC3H1、THAP2、TMEM19、RAB21、TBC1D15、MRS2P2、TPH2、TRHD E-AS1、TRHDE、LOC100507363、LOC100507377、ATXN7L3B、KCNC2、CAPS2、GLI PR1L1、GLIPR1L2、GLIPR1、KRR1、PHLDA1、NAP1L1、BBS10、OSBPL8、ZDHHC17、 CSRP2、E2F7、LOC100507484、NAV3、LOC100507498、SYT1、MIR1252、PAWR、PPP 1R12A、OTOGL、PTPRQ、MYF6、MYF5、LIN7A、MIR617、MIR618、ACSS3、MIR4699、 PPFIA2、CCDC59、METTL25、TMTC2、SLC6A15、TSPAN19、LRRIQ1、ALX1、RASSF9 、NTS、MGAT4C、LOC100507559、MKRN9P、C12orf50、C12orf29、CEP290、TMTC3 、KITLG、LOC728084、DUSP6、POC1B、POC1B-GALNT4、GALNT4、ATP2B1、LOC3387 58、LOC100507594、LINC00615、CCER1、EPYC、KERA、LUM、DCN、LOC256021、BT G1、CLLU1OS、CLLU1、C12orf74、PLEKHG7、EEA1、LOC643339、NUDT4、UBE2N、M RPL42、SOCS2-AS1、SOCS2、CRADD、PLXNC1、CCDC41、LOC144486、MIR5700、TM CC3、MIR492、KRT19P2、NDUFA12、NR2C1、FGD6、VEZT、MIR331、MIR3685、METAP 2、USP44、NTN4、LOC100505645、SNRPF、CCDC38、AMHDD1、HAL、LTA4H、ELK3、C DK17、C12orf55、LOC100996254、NEDD1、RMST、MIR1251、MIR135A2、RNU6-36 、MIR4495、MIR4303、SLC9A7P1、LOC643770、TMPO-AS1、TMPO、SLC25A3、SNORA53、IKBIP、APAF1、ANKS1B、FAM71C、UHRF1BP1L、GOLGA2P5、MIR1827、ACTR6、DEPDC4、SCYL2、SLC17A8、NR1H4、GAS2L3、ANO4、SLC5A8、UTP20、ARL1、SPIC、MYBPC1、CHPT1、SYCP3、GNPTAB、DRAM1、CCDC53、NUP37、 PARPBP、PMCH、IGF1、LINC00485、PAH、ASCL1、C12orf42、STAB2、NT5DC3、GNN 、HSP90B1、MIR3652、C12orf73、TDG、GLT8D2、HCFC2、NFYB、TXNRD1、EID3、CH ST11、IGANRP、MIR3922、SLC41A2、C12orf45、ALDH1L2、KIAA1033、APPL2、C1 2orf75、NUAK1、CKAP4、TCP11L2、POLR3B、LOC100287944、RFX4、LOC10050597 8、RIC8B、C12orf23、MTERFD3、CRY1、BTBD11、PWP1、PRDM4、ASCL4、LOC72873 9、WSCD2、CMKLR1、FICD、SART3、ISCU、TMEM119、SELPLG、MIR4496、CORO1C、SS H1、MIR619、DAO、SVOP、USP30-AS1、USP30、ALKBH2、UNG、ACACB、FOXN4、MYO1 H、KCTD10、UBE3B、MMAB、MVK、FAM222A、FAM222A-AS1、TRPV4、MIR4497、GLTP、 TCHP、GIT2、ANKRD13A、C12orf76、IFT81、ATP2A2、ANAPC7、ARPC3、GPN3、FAM 216A、VPS29、RAD9B、PPTC7、TCTN1、HVCN1、PPP1CC、CCDC63、MYL2、LOC10013 1138、CUX2、FAM109A、SH2B3、ATXN2、BRAP、ACAD10、ALDH2、MAPKAPK5-AS1、M APKAPK5、ADAM1A、TMEM116、ERP29、NAA25、MIR3657、TRAFD1、HECTD4、RPL6、P TPN11、MIR1302-1、RPH3A、OAS1、OAS3、OAS2、DTX1、RASAL1、CCDC42B、DDX54 、C12orf52、IQCD、TPCN1、SLC24A6、PLBD2、SDS、SDSL、LHX5、LOC100506465、R BM19、TBX5、TBX5-AS1、TBX3、MED13L、MIR620、MIR4472-2、LINC00173、MAP1 LC3B2、C12orf49、RNFT2、HRK、FBXW8、TESC、FBXO21、NOS1、KSR2、RFC5、WSB2、LOC100128895、VSIG10、PEBP1、TAOK3、SUDS3、SRRM4、HSPB8、LOC144742、CCDC60、TMEM233、PRKAB1、CIT、MIR1178、CCDC64、RAB35、GCN1L1、MIR4498、RPLP0、PXN-AS1、PXN、LOC100996317、RNU4-2、RNU4-1、SIRT4、PLA2G1B、MSI1、COX6A1、TRIAP1、GATC、SRSF9、DYNLL1、LOC100506668、COQ5、RNF10、POP5、CABP1、MLEC、UNC119B、MIR4700、ACADS、SPPL3、HNF1A-AS1、HNF1A、C12orf43、OASL、P2RX7、P2RX4、CAMKK2、ANAPC5、RNF34、KDM2B、ORAI1、MORN3、TMEM120B、RHOF、LOC338799、SETD1B、HPD、PSMD9、WDR66、BCL7A、LOC100506691、MLXIP、LRRC43、IL31、B3GNT4、DIABLO、VPS33A、CLIP1、LOC100507066、ZCCHC8、RSRC2、KNTC1、HCAR2、HCAR3、HCAR1、DENR、CCDC62、HIP1R、VPS37B、ABCB9、OGFOD2、ARL6IP4、PITPNM2、MIR4304、LOC100507091、MPHOSPH9、C12orf65、CDK2AP1、SBNO1、LOC100293704、SETD8、RILPL2、SNRNP35、RILPL1、MIR3908、TMED2、DDX55、EIF2B1、GTF2H3、TCTN2、ATP6V0A2、DNAH10、CCDC92、ZNF664、ZNF664-FAM101A、FAM101A、NCOR2、SCARB1、UBC、MIR5188、DHX37、BRI3BP、AACS、TMEM132B、LOC400084、LOC100128554、LOC100996671、LOC387895、LOC100507206、LOC440117、FLJ37505、LINC00507、MIR4419B、TMEM132C、MIR3612、SLC15A4、LOC100128276、GLT1D1、TMEM132D、LOC100190940、FLJ31485、FZD10、PIWIL1、RIMBP2、STX2、RAN、GPR133、LOC100128840、LOC116437、LOC100128002、LOC338797、LOC100996701、SFSWAP、MMP17、ULK1、PUS1、EP400、SNORA49、EP400NL、DDX51、 NOC4L、LOC100996246、GALNT9、LOC100130238、LOC100506978、FBRSL1、LOC100996573、LRCOL1、P2RX2、POLE、PXMP2、PGAM5、ANKLE2、GOLGA3、CHFR、ZNF 605、ZNF26、ZNF84、ZNF140、ZNF10、ZNF268、ANHX、ANKRD20A9P、RNU6-55、RNU6-76、LOC100652856、LINC00442、RNU6-52、TUBA3C、ANKRD26P3、LINC00442 1、TPTE2、MPHOSPH8、PSPC1、ZMYM5、ZMYM2、GJA3、GJB2、GJB6、CRYL1、MIR4499、IFT88、IL17D、N6AMT2、XPO4、LATS2、SAP18、SKA3、MRP63、MIPEPP3、LINC0 0539、ZDHHC20、EFHA1、RNU6-59、FGF9、LINC00424、LINC00540、BASP1P1、SGCG、RNU6-58、SACS、SACS-AS1、LINC00327、TNFRSF19、MIPEP、C1QTNF9B-AS1 、C1QTNF9B、ANKRD20A19P、SPATA13、MIR2276、SPATA13-AS1、C1QTNF9、PARP4、TPTE2P6、ATP12A、RNF17、CENPJ、TPTE2P1、LOC100996470、PABPC3、FAM12 3A、LOC100996347、MTMR6、NUPL1、ATP8A2、RNU6-78、SHISA2、RNF6、CDK8、WASF3、GPR12、USP12、RPL21、SNORD102、SNORA27、RASL11A、GTF3A、MTIF3、RNU 6-63, LNX2, POLR1D, LOC100506997, GSX1, PDX1, ATP5EP2, LINC00543, CDX2, PRHOXNB, FLT3, PAN3-AS1, PAN3, RNU6-82, FLT1, POMP, SLC46A3, RNU6-53, MTUS2, MTUS2-AS1, SLC7A1, UBL3, LINC00297, LINC00544, KATNAL1, RNU6-64, LINC00427, LINC00426, HMGB1, USPL1, ALOX5AP, LINC00398, LINC00545,TEX26-AS1、MEDAG、TEX26、HSPH1、B3GALTL、RXFP2、EEF1DP3、FRY-AS1、FRY、ZAR1L、BRCA2、N4BP2L1、N4BP2L2、MINOS1P1、N4BP2L2-IT2、PDS5B、LINC0042 3、KL、STARD13、STARD13-AS2、RFC3、LINC00457、NBEA、MAB21L1、LINC00445、DCLK1、SOHLH2、CCDC169-SOHLH2、CCDC169、RNU6-71、SPG20、SPG20OS、CCNA 1、SERTM1、RFXAP、SMAD9、ALG5、EXOSC8、FAM48A、CSNK1A1L、LINC00547、POSTN、TRPC4、LINC00571、UFM1、LINC00366、FREM2、RNU6-56、STOML3、PROSER1、NHLRC3、LHFP、COG6、MIR4305、LINC00332、LINC00548、LINC00598、FOXO1、MIR320D1、MRPS31、SLC25A15、TPTE2P5、MIR621、SUGT1P3、ELF1、WBP4、MIR316 8、KBTBD6、KBTBD7、MTRF1、NAA16、RNU6-57、OR7E37P、RGCC、VWA8、MIR5006、VWA8-AS1、DGKH、AKAP11、TNFSF11、FAM216B、EPSTI1、DNAJC15、ENOX1、CCDC1 22、LACC1、LINC00284、SMIM2、SMIM2-IT1、SERP2、TSC22D1、TSC22D1-AS1、LINC00330、NUFIP1、KIAA1704、LOC100996395、GTF2F2、RNU6-69、KCTD4、TPT1 、SNORA31、TPT1-AS1、SLC25A30、SLC25A30-AS1、COG3、FAM194B、SPERT、SIAH3、ZC3H13、CPB2-AS1、CPB2、LCP1、LINC00563、KIAA0226L、RNU6-68、LOC731 932、LRCH1、ESD、HTR2A、SUCLA2、NUDT15、MED4、MED4-AS1、ITM2B、LINC00441、RB1、LPAR6、RCBTB2、LOC100996412、LOC100996416、LINC00462、CYSLTR2、FNDC3A、MLNR、CDADC1、CAB39L、SETDB2、PHF11、RCBTB1、ARL11、EBPL、KPNA3、CTAGE10P、SPRYD7、DLEU2、MIR3613、TRIM13、KCNRG、MIR16-1、MIR15A、DLEU1、FLJ31945、ST13P4、DLEU7、DLEU7-AS1、RNASEH2B-AS1、 RNASEH2B、GUCY1B2、LINC00371、FAM124A、SERPINE3、MIR5693、INTS6、INTS 6-AS1、MIR4703、WDFY2、DHRS12、LINC00282、CCDC70、ATP7B、ALG11、UTP14C 、LOC100506859、NEK5、NEK3、MRPS31P5、TPTE2P2、THSD1、VPS36、CKAP2、TPT E2P3、HNRNPA1L2、SUGT1、LECT1、MIR759、PCDH8、OLFM4、LINC00558、LINC004 58、MIR1297、MIR5007、PRR20A、PRR20B、PRR20C、PRR20D、PRR20E、PCDH17、D IAPH3、DIAPH3-AS1、DIAPH3-AS2、TDRD3、MIR3169、PCDH20、OR7E156P、LOC64 7264, RNU6-81, MIR548X2, MIR4704, PCDH9, PCDH9-AS2, PCDH9-AS3, LINC00550, KLHL1, ATXN8OS, LINC00348, DACH1, MZT1, BORA, DIS3, PIBF1, RNU6-79 KLF5、RNU6-66、KLF12、LINC00402、LOC100288208、LINC00381、LINC00347、 CTAGE11P、TBC1D4、COMMD6、UCHL3、LMO7、C13orf45、KCTD12、BTF3P11、IRG1、 CLN5、FBXL3、MYCBP2、MYCBP2-AS1、SCEL、LOC100129307、SLAIN1、MIR3665、 LOC100505518、EDNRB、LINC00439、LINC00446、POU4F1-AS1、POU4F1、RNF219 、LINC00331、RBM26、RBM26-AS1、NDFIP2-AS1、NDFIP2、SPRY2、RNU6-67、SLI TRK1、LINC00333、LINC00351、RNU6-72、SLITRK6、MIR4500HG、MIR4500、SLIT RK5、LINC00433、LINC00353、LINC00559、MIR622、RNU6-75、LINC00410、LIN C00379、MIR17HG、MIR17、MIR18A、MIR19A、MIR20A、MIR19B1、MIR92A1、GPC5、MIR548AS、GPC5-AS1、GPC6、GPC6-AS2、DCT、TGDS、GPR180、SOX21、ABCC4、CL DN10、CLDN10-AS1、DZIP1、DNAJC3、UGGT2、HS6ST3、MIR4501、LINC00359、OX GR1、MBNL2、RAP2A、IPO5、FARP1、RNF113B、MIR3170、STK24、SLC15A1、DOCK9 、RNU6-83、UBAC2-AS1、UBAC2、GPR18、GPR183、FKSG29、MIR623、TM9SF2、CLY BL、MIR4306、ZIC5、ZIC2、PCCA、PCCA-AS1、GGACT、LOC100507654、TMTC4、LO C100996276、NALCN-AS1、NALCN、ITGBL1、FGF14、MIR2681、MIR4705、FGF14- IT1、FGF14-AS2、TPP2、METTL21C、CCDC168、TEX30、KDELC1、BIVM、BIVM-ERC C5、ERCC5、METTL21EP、SLC10A2、DAOA-AS1、DAOA、LINC00343、LINC00460、EF NB2、ARGLU1、LINC00551、LINC00443、FAM155A、MIR1267、LIG4、ABHD13、TNF SF13B、MYO16、MYO16-AS1、IRS2、COL4A1、COL4A2、COL4A2-AS2、COL4A2-AS1 、RAB20、CARKD、CARS2、ING1、LINC00346、ANKRD10、ANKRD10-IT1、LOC10099 6267、ARHGEF7、TEX29、SOX1、LINC00403、SPACA7、TUBGCP3、C13orf35、ATP11 A、LOC100506063、MCF2L-AS1、MCF2L、F7、F10、PROZ、PCID2、CUL4A、LAMP1、G RTP1、ADPRHL1、DCUN1D2、TMCO3、TFDP1、ATP4B、GRK1、LINC00552、FAM70B、G AS6-AS1、GAS6、LOC100506394、LINC00452、LINC00565、RASA3、CDC16、MIR5 48AR、MIR4502、UPF3A、CHAMP1、OR11H12、LOC642426、POTEG、LOC100506303、FLJ39632、THEN、OR11H2、OR4Q3、OR4M1、OR4N2、OR4K2、OR4K5、OR4K1、OR4K15、OR4K14、OR4K13、OR4L1、OR4K17、OR4N5、OR11G2、OR11H6、OR11H4、TTC5、CCNB1IP1、SNORD126、 RPPH1, PARP2, TEP1, KLHL33, OSGEP, APEX1, TMEM55B, PNP, RNASE10, RNASE9 RNASE11, RNASE12, OR6S1, ANG, RNASE4, EDDM3A, EDDM3B, RNASE6, RNASE1 LOC100507513, RNASE3, ECRP, RNASE2, METTL17, SLC39A2, NDRG2, TPPP2, RN ASE13, RNASE7, RNASE8, ARHGEF40, ZNF219, TMEM253, OR5AU1, LINC00641, HN RNPC, RPGRIP1, SUPT16H, CHD8, SNORD9, SNORD8, RAB2B, TOX4, METTL3, SALL 2. OR10G3, OR10G2, OR4E2, DAD1, ABHD4, OXA1L, SLC7A7, MRPL52, MMP14, LRP 10. REM2, RBM23, PRMT5-AS1, PRMT5, HAUS4, MIR4707, AJUBA, C14orf93, PSM B5, PSMB11, CDH24, ACIN1, C14orf119, LOC100128908, CEBPE, SLC7A8, C14or f164, HOMEZ, PPP1R3E, BCL2L2-PABPN1, BCL2L2, PABPN1, SLC22A17, EFS, IL 25. CMTM5, MYH6, MIR208A, MYH7, MIR208B, NGDN, THTPA, ZFHX2, AP1G2, JPH4 DHRS2, DHRS4-AS1, DHRS4, DHRS4L2, DHRS4L1, LRRC16B, CPNE6, NRL, PCK2 DCAF11, FITM1, PSME1, EMC9, PSME2, ​​RNF31, IRF9, REC8, IPO4, TM9SF1, TSSK4 CHMP4A, MDP1, NEDD8-MDP1, NEDD8, GMPR2, TINF2, TGM1, RABGGTA, DHRS1, N.S OP9, CIDEB, LTB4R2, LTB4R, ADCY4, RIPK3, NFATC4, NYNRIN, CBLN3, KHNYN, SD R39U1, CMA1, CTSG, GZMH, GZMB, STXBP6, NOVA1, MIR4307, LOC728755, LINC0 0645, FOXG1, C14orf23, LOC100506004, LOC100996589, PRKD1, G2E3, SCFD1.COCH、LOC100506071、STRN3、MIR624、AP4S1、HECTD1、HEATR5A、DTD2、GPR33 、NUBPL、LOC100506110、ARHGAP5-AS1、ARHGAP5、AKAP6、NPAS3、EGLN3、SPTS SA、EAPP、RNU1-7、RNU1-8、SNX6、CFL2、BAZ1A、IGBP1P1、LOC100506157、SRP 54、FAM177A1、PPP2R3C、KIAA0391、PSMA6、NFKBIA、INSM2、RALGAPA1、BRMS1L 、PTCSC3、MBIP、SFTA3、NKX2-1、NKX2-1-AS1、NKX2-8、PAX9、SLC25A21、MIR4 503、LOC100129794、MIPOL1、FOXA1、TTC6、SSTR1、CLEC14A、LINC00639、SEC 23A、GEMIN2、TRAPPC6B、PNN、MIA2、CTAGE5、LOC100288846、FBXO33、LRFN5、 FSCB、C14orf28、KLHL28、FAM179B、LOC100996613、PRPF39、SNORD127、FKBP3 、FANCM、MIS18BP1、RPL10L、MDGA2、MIR548Y、LINC00648、RPS29、RN7SL1、LR R1、RPL36AL、MGAT2、DNAAF2、POLE2、KLHDC1、KLHDC2、NEMF、RN7SL2、ARF6、C 14orf182、LOC100506499、C14orf183、METTL21D、SOS2、L2HGDH、MIR4504、A TP5S、CDKL1、MAP4K5、ATL1、SAV1、NIN、ABHD12B、PYGL、TRIM9、TMX1、LINC006 40、FRMD6-AS2、FRMD6、FRMD6-AS1、GNG2、C14orf166、NID2、PTGDR、PTGER2、 TXNDC16、GPR137C、ERO1L、PSMC6、STYX、GNPNAT1、FERMT2、DDHD1、MIR5580、B MP4、CDKN3、CNIH、GMFB、CGRRF1、SAMD4A、GCH1、MIR4308、WDHD1、SOCS4、MAP K1IP1L、LGALS3、DLGAP5、FBXO34、ATG14、TBPL2、KTN1-AS1、KTN1、RPL13AP3、LINC00520、PELI2、C14orf101、OTX2、OTX2-AS1、EXOC5、AP5M1、NAA30、C14orf105、SLC35F4、C14orf37、ACTR10、PSMA3、FLJ31306、 ARID4A、TOMM20L、TIMM9、KIAA0586、DACT1、DAAM1、GPR135、L3HYPDH、JKAMP、CCDC175、RTN1、MIR5586、LRRC9、PCNXL4、DHRS7、PPM1A、C14orf39、SIX6、SIX1、SIX4、MNAT1、TRMT5、SLC38A6、TMEM30B、PRKCH、FLJ22447、HIF1A、HIF1A-AS2、SNAPC1、SYT16、LINC00643、KCNH5、RHOJ、GPHB5、PPP2R5E、WDR89、SGPP1、SYNE2、MIR548H1、ESR2、TEX21P、MTHFD1、AKAP5、ZBTB25、ZBTB1、HSPA2、PPP1R36、PLEKHG3、SPTB、CHURC1、CHURC1-FNTB、GPX2、RAB15、FNTB、MAX、MIR4706、LOC100506321、MIR4708、FUT8、FUT8-AS1、MIR625、LINC00238、GPHN、FAM71D、MPP5、ATP6V1D、EIF2S1、PLEK2、MIR5694、TMEM229B、PLEKHH1、PIGH、ARG2、VTI1B、RDH11、RDH12、ZFYVE26、RAD51B、LOC100996664、ZFP36L1、ACTN1、DCAF5、EXD2、GALNTL1、ERH、SLC39A9、PLEKHD1、CCDC177、KIAA0247、LOC100289511、SRSF5、SLC10A1、LOC100506358、SMOC1、SLC8A3、ADAM21P1、SYNJ2BP-COX16、COX16、SYNJ2BP、ADAM21、ADAM20P1、ADAM20、MED6、TTC9、MAP3K9、PCNX、SNORD56B、LOC145474、SIPA1L1、RGS6、DPF3、DCAF4、ZFYVE1、RBM25、PSEN1、PAPLN、NUMB、HEATR4、C14orf169、ACOT1、ACOT2、ACOT4、ACOT6、DNAL1、PNMA1、ELMSAN1、MIR4505、LOC100506476、LOC100506498、PTGR2、ZNF410、FAM161B、COQ6、ENTPD5、CCDC176、ALDH6A1、LIN52、VSX2、ABCD4、VRTN、SYNDIG1L、NPC2、MIR4709、ISCA2、LTBP2、KIAA0317、FCF1、YLPM1、PROX2、DL ST、RPS6KL1、PGF、EIF2B2、MLH3、ACYP1、ZC2HC1C、NEK9、TMED10、FOS、LOC731 223、JDP2、BATF、FLVCR2、C14orf1、TTLL5、TGFB3、IFT43、GPATCH2L、ESRRB、 VASH1、ANGEL1、C14orf166B、IRF2BPL、KIAA1737、ZDHHC22、TMEM63C、NGB、MI R1260A、POMT2、GSTZ1、TMED8、SAMD15、NOXRED1、VIPAS39、AHSA1、ISM2、SPT LC2、ALKBH1、SLIRP、SNW1、C14orf178、ADCK1、NRXN3、DIO2、DIO2-AS1、CEP12 8、TSHR、GTF2A1、SNORA79、STON2、LOC100506700、SEL1L、LOC100996280、FL RT2、LOC100506718、LOC283585、GALC、GPR65、LOC283587、KCNK10、SPATA7、P TPN21、ZC3H14、EML5、TTC8、FOXN3、LOC100128075、FOXN3-AS1、FOXN3-AS2、 LOC100506792、EFCAB11、TDP1、KCNK13、PSMC1、NRDE2、CALM1、LINC00642、TT C7B、LOC283588、RPS6KA5、C14orf159、SNORA11B、GPR68、CCDC88C、SMEK1、C ATSPERB、TC2N、FBLN5、TRIP11、ATXN3、NDUFB1、CPSF2、SLC24A4、RIN3、LGMN、 GOLGA5, CHGA, ITPK1, ITPK1-AS1, MOAP1, TMEM251, C14orf142, UBR7, BTBD7, UNC79, COX8C, PRIMA1, FAM181A-AS1, FAM181A, ASB2, MIR4506, LINC00521, OTUB2, DDX24, IFI27L1, IFI27, IFI27L2, PPP4R4, SERPINA10, SERPINA6, SERPINA1, SERPINA11, SERPINA9, SERPINA12, SERPINA4, SERPINA5, SERPINA3SERPINA13P、GSC、DICER1、MIR3173、DICER1-AS1、CLMN、LINC00341、SYNE3、LOC100506972、SNHG10、SCARNA13、GLRX5、LOC100506999、TCL6、TCL1B、TCL1A、 LOC100133207、LINC00617、C14orf132、BDKRB2、BDKRB1、LOC100130815、ATG2B、GSKIP、AK7、PAPOLA、VRK1、LOC100129345、C14orf64、C14orf177、BCL11B、SETD3、CCNK、CCDC85C、LOC100507108、HHIPL1、CYP46A1、EML1、EVL、MIR151B、MIR342、DEGS2、YY1、SLC25A29、MIR345、SLC25A47、WARS、WDR25、BEGAIN、LINC00523、DLK1、MIR2392、MEG3、MIR770、MIR493、MIR337、MIR665、RTL1、MIR431、MIR433、MIR127、MIR432、MIR136、LOC100288160、MEG8、SNORD112、MIR370、SNORD113-1、SNORD113-2、SNORD113-3、SNORD113-4、SNORD113-5、SNORD113-6、SNORD113-7、SNORD113-8、SNORD113-9、LOC100507242、SNORD114-1、SNORD114-2、SNORD114-3、SNORD114-4、SNORD114-5、SNORD114-6、SNORD114-7、SNORD114-8、SNORD114-9、SNORD114-10、SNORD114-11、SNORD114-12、SNORD114-13、SNORD114-14、SNORD114-15、SNORD114-16、SNORD114-17、SNORD114-18、SNORD114-19、SNORD114-20、SNORD114-21、SNORD114-22、SNORD114-23、SNORD114-24、SNORD114-25、SNORD114-26、SNORD114-27、SNORD114-28、SNORD114-29、SNORD114-30、SNORD114-31、MIR379、MIR411、MIR299、MIR380、MIR1197、MIR323A、MIR758、MIR329-1、MIR329-2、MIR494、MIR1193、MIR543、MIR495、MIR376C、MIR376A2、MIR654、MIR376B、MIR376A1、MIR300、MIR1185-1、MIR1185-2、MIR381、MIR487B、MIR539、MIR889、MIR544A、MIR655、MIR487A、MIR382、MIR134、MIR668、MIR485、MIR323B、MIR154、MI R496、MIR377、MIR541、MIR409、MIR412、MIR369、MIR410、MIR656、MEG9、LOC100507277、DIO3OS、MIR1247、DIO3、LINC00239、PPP2R5C、LOC100653021、D YNC1H1、HSP90AA1、WDR20、MOK、ZNF839、CINP、TECPR2、ANKRD9、MIR4309、RCOR1、TRAF3、AMN、CDC42BPB、EXOC3L4、TNFAIP2、LINC00605、EIF5、SNORA28、 MARK3、CKB、TRMT61A、BAG5、APOPT1、KLC1、XRCC3、ZFYVE21、PPP1R13B、LINC00637、C14orf2、TDRD9、RD3L、ASPG、MIR203、MIR3545、KIF26A、C14orf180、L OC100288144、TMEM179、MIR4710、INF2、ADSSL1、SIVA1、AKT1、ZBTB42、LINC00638、KIAA0284、PLD4、AHNAK2、C14orf79、CDCA4、GPR132、JAG2、NUDT14、B RF1、BTBD6、PACS2、TEX22、LOC100507437、MTA1、LOC100128343、CRIP2、CRIP1、C14orf80、TMEM121、MIR4507、KIAA0125、ADAM6、LINC00226、LINC00221、 CHEK2P2、HERC2P3、GOLGA6L6、GOLGA8CP、NBEAP1、MIR3118-4、MIR5701-1、LOC348120、LOC646214、CXADRP2、MIR3118-6、NF1P2、MIR5701-2、LOC727924 、OR4M2、OR4N4、OR4N3P、MIR1268A、REREP3、MIR4509-1、GOLGA8DP、GOLGA6L1、TUBGCP5、CYFIP1、NIPA2、NIPA1、LOC283683、WHAMMP3、GOLGA8I、HERC2P2、HERC2P7、GOLGA8EP、LOC100996599、LOC440243、GOLGA8S、GOLGA6L2、MIR4508、MKRN3、MAGEL2、NDN PWRN2、PWRN1、NPAP1、SNRPN、SNURF、SNORD107、PAR-SN、PAR5、SNORD64、SNORD108、LOC100506948、 SNORD109A、SNORD116-1、SNORD116-2、SNORD116-3、SNORD116-4、SNORD116-5、SNORD116-6、SNORD116-7、SNORD116-8、SNORD116-9、SNORD116-10、SNORD116-11、SNORD116-12、SNORD116-13、SNORD116-14、SNORD116-15、SNORD116-16、SNORD116-17、SNORD116-18、SNORD116-19、SNORD116-20、SNORD116-21、SNORD116-22、SNORD116-23、SNORD116-24、SNORD116-25、SNORD116-26、SNORD116-27、SNORD116-28、SNORD116-29、IPW、PAR1、SNORD115-1、SNORD115-2、SNORD115-3、SNORD115-4、SNORD115-5、SNORD115-6、SNORD115-7、SNORD115-8、SNORD115-9、SNORD115-10、SNORD115-11、SNORD115-12、SNORD115-13、SNORD115-14、SNORD115-15、SNORD115-16、SNORD115-17、SNORD115-18、SNORD115-19、SNORD115-20、SNORD115-21、SNORD115-22、PAR4、SNORD115-23、SNORD115-24、SNORD115-25、SNORD115-26、SNORD115-27、SNORD115-28、SNORD115-29、SNORD115-30、SNORD115-31、SNORD115-32、SNORD115-33、SNORD115-34、SNORD115-35、SNORD115-36、SNORD115-37、SNORD115-38、SNORD115-39、SNORD115-40、SNORD115-41、SNORD115-42、SNORD115-43、SNORD115-44、SNORD115-45、SNORD115-47、SNORD115-48、SNORD109B、UBE3A、ATP10A、MIR4715、LOC100128714、LOC503519、GABRB3、GABRA5、GABRG3、OCA2、HERC2、LOC100996625、LOC645202、GOLGA8F、MIR4509-2、MIR4509-3、GOLGA8G、LOC100132202、LOC100996644、HERC2P9、WHAMMP2、LOC100289656、LOC6 46278、GOLGA6L7P、APBA2、FAM189A1、NDNL2、LOC100130111、TJP1、GOLGA8J、ULK4P3、GOLGA8T、DKFZP434L187、CHRFAM7A、LOC100996413、ULK4P2、GOLGA8T 8H、ARHGAP11B、LOC100288637、HERC2P10、FAN1、MTMR10、TRPM1、MIR211、LOC283710、KLF13、OTUD7A、CHRNA7、LOC100996675、GOLGA8K、ULK4P1、GOLGA8 O、WHAMMP1、LOC100996255、ARHGAP11A、SCG5、GREM1、FMN1、TMCO5B、RYR3、AVEN、CHRM5、EMC7、PGBD4、KATNBL1、EMC4、SLC12A6、NOP10、C15orf55、LPCAT4 、GOLGA8A、MIR1233-1、GOLGA8B、MIR1233-2、GJD2、ACTC1、AQR、ZNF770、ANP32AP1、ATPBD4、MIR3942、ATPBD4-AS1、MIR4510、LOC100507480、C15orf41、 CSNK1A1P1、LOC145845、MEIS2、TMCO5A、SPRED1、FAM98B、RASGRP1、C15orf53、C15orf54、THBS1、FSIP1、GPR176、LOC100505534、EIF2AK4、SRP14、LOC100 131089, BMF, BUB1B, PAK6, C15orf56, ANKRD63, PLCB2, C15orf52, PHGR1, DISP2, C15orf23, IVD, BAHD1, CHST14, MRPL42P5, C15orf57, RPUSD2, CASC5, LOC100505648, RAD51, FAM82A2, GCHFR, DNAJC17, C15orf62, ZFYVE19, PPP1R14D, SPINT1, RHOV, VPS18, DLL4, CHAC1, INO80, EXD1, CHP1, OIP5-AS1, OIP5,NUSAP1, NDUFAF1, RTF1, ITPKA, LTK, RPAP1, TYRO3, MGA, MIR626, MAPKBP1, JMJD7, JMJD7-PLA2G4B, PLA2G4B, SPTBN5, MIR4310, LOC100289090, EHD4, PLA2G4E, PLA2G4D, PLA2G4F, VPS39, MIR627, TMEM87A GANC、CAPN3、ZFP106、SNAP23、LRRC57、HAUS2、STARD9、CDAN1、TTBK2、UBR1、 TMEM62、CCNDBP1、EPB42、TGM5、TGM7、LCMT2、ADAL、ZSCAN29、TUBGCP4、TP53 BP1、MAP1A、PPIP5K1、CKMT1B、STRC、CATSPER2、CKMT1A、CATSPER2P1、PDIA3 、ELL3、SERF2、SERF2-C15ORF63、MIR1282、SERINC4、HYPK、MFAP1、WDR76、FR MD5、PIN4P1、CASC4、CTDSPL2、LOC645212、EIF3J、SPG11、PATL2、B2M、TRIM6 9、C15orf43、SORD、DUOX2、DUOXA2、DUOXA1、DUOX1、SHF、SLC28A2、GATM、GAT M-AS1、SPATA5L1、C15orf48、MIR147B、SLC30A4、HMGN2P46、BLOC1S6、SQRDL 、SEMA6D、SLC24A5、MYEF2、CTXN2、SLC12A1、DUT、FBN1、LOC100506059、CEP15 2、SHC4、EID1、SECISBP2L、COPS2、GALK2、NDUFAF4P1、MIR4716、FAM227B、FG F7、DTWD1、ATP8B4、SLC27A2、HDC、GABPB1、FLJ10038、GABPB1-AS1、MIR4712 、USP8、USP50、TRPM7、SPPL2A、AP4E1、DCAF13P3、TNFAIP8L3、CYP19A1、MIR4 713、LOC100652954、LOC100996299、GLDN、DMXL2、SCG3、LYSMD2、TMOD2、TMO D3、LEO1、MAPK6、BCL2L10、GNB5、LOC100129973、MYO5C、MIR1266、MYO5A、EN PP19、FAM214A、ONECUT1、WDR72、UNC13C、RSL24D1、RAB27A、PIGB、DYX1C1-C CPG1、CCPG1、MIR628、FLJ27352、DYX1C1、PYGO1、PRTG、NEDD4、RFX7、TEX9、M NS1、ZNF280D、LOC145783、TCF12、LOC283663、CGNL1、GCOM1、MYZAP、POLR2M、ALDH1A2、AQP9、LIPC、ADAM10、HSP90AB4P、FAM63B、SLTM、RNF111、CCNB2、MY O1E、MIR2116、LDHAL6B、FAM81A、GCNT3、GTF2A2、BNIP2、FOXB1、ANXA2、NARG 2、RORA、LOC100506530、VPS13C、C2CD4A、C2CD4B、MGC15885、TLN2、MIR190A 、TPM1、LOC100128979、LACTB、RPS27L、RAB8B、APH1B、CA12、USP3、LOC10013 0855、FBXL22、HERC1、MIR422A、DAPK2、FAM96A、SNX1、SNX22、PPIB、CSNK1G1 、KIAA0101、TRIP4、ZNF609、OAZ2、RBPMS2、MIR1272、PIF1、PLEKHO2、ANKDD1 A、SPG21、MTFMT、SLC51B、RASL12、KBTBD13、UBAP1L、PDCD7、CLPX、CILP、PAR P16、RNU5A-1、RNU5B-1、IGDCC3、IGDCC4、DPP8、PTPLAD1、RNU6-19、VWA9、SLC 24A1、DENND4A、MIR4511、RAB11A、MEGF11、MIR4311、DIS3L、TIPIN、SCARNA1 4、MAP2K1、SNAPC5、MIR4512、RPL4、SNORD18C、SNORD18B、SNORD16、SNORD18 A、ZWILCH、LCTL、SMAD6、SMAD3、AAGAB、IQCH、IQCH-AS1、C15orf61、MAP2K5、 SKOR1、RNU6-1、PIAS1、CALML4、CLN6、FEM1B、ITGA11、CORO2B、ANP32A、MIR43 12、ANP32A-IT1、SPESP1、NOX5、LINC00277、GLCE、PAQR5、LOC145694、KIF23 、RPLP1、LOC145837、LINC00593、TLE3、MIR629、UACA、LARP6、THAP10、LRRC4 9、CT62、THSD4、NR2E3、MYO9A、SENP8、GRAMD2、PKM、PARP6、CELF6、HEXA、HEX A-AS1、TMEM202、ARIH1、MIR630、LOC646670、GOLGA6B、HIGD2B、BBS4、ADPGK、ADPGK-AS1、NEO1、HCN4、C15orf60、NPTN、CD276、C15orf59、TBC1D21、LOXL1-AS1、LOXL1、STOML1、PML、GOLGA6A、LOC732265、LOC283731、ISLR2、ISLR、 STRA6、CCDC33、CYP11A1、LOC729739、SEMA7A、UBL7、LOC440288、ARID3B、CLK3、EDC3、CYP1A1、CYP1A2、CSK、MIR4513、LMAN1L、CPLX3、ULK3、SCAMP2、MPI 、FAM219B、COX5A、RPP25、SCAMP5、PPCDC、C15orf39、GOLGA6C、GOLGA6D、COMMD4、NEIL1、MIR631、MAN2C1、SIN3A、PTPN9、SNUPN、IMP3、SNX33、CSPG4、ODF3 L1、DNM1P35、MIR4313、LOC441728、LOC730058、UBE2Q2、FBXO22、FBXO22-AS1、NRG4、C15orf27、ETFA、TYRO3P、ISL2、SCAPER、MIR3713、RCN2、PSTPIP1、T SPAN3、PEAK1、LINC00597、HMG20A、LINGO1、LOC253044、LOC645752、LOC440292、LOC91450、TBC1D2B、SH2D7、CIB2、IDH3A、ACSBG1、DNAJA4、WDR61、CRABP 1、IREB2、AGPHD1、PSMA4、CHRNA5、CHRNA3、CHRNB4、LOC646938、ADAMTS7、MORF4L1、CTSH、RASGRF1、LOC100129540、LOC729911、MIR184、ANKRD34C、TMED3、KIAA1024、MTHFS、ST20-MTHFS、ST20、C15orf37、BCL2A1、ZFAND6、FAH、LOC100996492、LOC283688、ARNT2、LOC100133746、FAM108C1、KIAA1199、MIR54 9、MESDC2、MIR4514、MESDC1、C15orf26、IL16、STARD5、TMC3、MEX3B、EFTUD1、FAM154B、LOC390660、GOLGA6L10、UBE2Q2P2、GOLGA6L9、LOC440297、AGSK1 、RPS17、LOC643696、UBE2Q2P3、LOC727849、RPS17L、CPEB1、LOC283692、AP3B2、LOC338963、LOC283693、LOC100505616、SCARNA15、FSD2、WHAM、HOMER2、FAM103A1、C15orf40、BTBD1、MIR4515、TM6SF1、HDGFRP3、BNC1、SH3GL3、ADA MTSL3、LOC648809、DNM1P41、LOC100505679、LOC440300、LOC388152、GOLGA 6L4、GOLGA6L5、UBE2Q2P1、LOC100506874、ZSCAN2、SCAND2、WDR73、NMB、SEC 11A、ZNF592、ALPK3、SLC28A1、PDE8A、LOC642423、GOLGA6L3、AKAP13、KLHL25 、MIR1276、MIR548AP、AGBL1、LOC727915、LINC00052、NTRK3、NTRK3-AS1、MR PL46、MRPS11、DET1、MIR1179、MIR7-2、MIR3529、AEN、ISG20、ACAN、HAPLN3、M FGE8、ABHD2、RLBP1、FANCI、POLG、MIR9-3、LOC254559、RHCG、LOC283761、TI CRR、KIF7、PLIN1、PEX11A、WDR93、MESP1、MESP2、ANPEP、AP3S2、C15orf38-AP 3S2, MIR5094, MIR5009, C15orf38, ZNF710, MIR3174, IDH2, SEMA4B, CIB1, GDPGP1, TTLL13, NGRN, GABARAPL3, ZNF774, IQGAP1, CRTC3, LOC100507079, BL M、FURIN、FES、MAN2A2、UNC45A、HDDC3、RCCD1、PRC1、LOC100507118、VPS33B 、SV2B、SLCO3A1、ST8SIA2、LOC100507166、C15orf32、LOC100144604、FAM174 B, LOC643797, ASB9P1, LOC100507217, LOC100996653, CHD2, MIR3175, RGMA, UNQ9370, LOC100996663, MCTP2, LOC400456, LOC145820, LOC100507311, LO C100507288、NR2F2-AS1、NR2F2、MIR1469、LOC100507325、LOC100652749、S PATA8、LOC91948、ARRDC4、FAM169B、IGF1R、MIR4714、PGPEP1L、SYNM、TTC23、LRRC28, MEF2A, LYSMD4, DNM1P46, ADAMTS17, FLJ42289, CERS3, LINS, ASB7, LOC440313, ALDH1A3, LRRK1, CHSY1, VIMP, SNRPA1, PCSK6, LOC100507472, TM2D3, TARSL2, LOC100128108, OR4F6, OR4F15、OR4F13P、OR4F4、FAM138E、MIR1302-10、WASH3P、DDX11L9、DDX11L1 0、POLR3K、SNRNP25、RHBDF1、MPG、NPRL3、HBZ、HBM、HBA2、HBA1、HBQ1、LUC7L 、ITFG3、RGS11、ARHGDIG、PDIA2、AXIN1、MRPL28、TMEM8A、LOC100134368、NM E4、DECR2、RAB11FIP3、LINC00235、SOLH、MIR5587、MIR3176、C16orf11、NHLR C4、PIGQ、RAB40C、WFIKKN1、C16orf13、LOC100287175、FAM195A、WDR90、RHO T2、RHBDL1、STUB1、JMJD8、WDR24、FBXL16、GS52、METRN、FAM173A、CCDC78、H AGHL, NARFL, MSLN, MIR662, RPUSD1, CHTF18, GNG13, PRR25, LMF1, SOX8, SSTR5-AS1, SSTR5, C1QTNF8, CACNA1H, TPSG1, TSB2, TPSAB1, TPSSD1, UBE2I, BAI AP3、TSR3、GNPTG、UNKL、C16orf91、CCDC154、CLCN7、PTX4、TELO2、IFT140、T MEM204、CRAMP1L、HN1L、MAPK8IP3、MIR3177、NME3、MRPS34、EME2、SPSB3、NU BP2、IGFALS、HAGH、FAHD1、MEIOB、LINC00254、HS3ST6、MSRB1、RPL3L、NDUFB 10、RPS2、SNORA10、SNORA64、SNHG9、SNORA78、RNF151、TBL3、NOXO1、GFER、SY NGR3、ZNF598、NPW、SLC9A3R2、NTHL1、TSC2、PKD1、MIR1225、MIR4516、MIR31 80-5、RAB26、LOC100507303、SNORD60、TRAF7、CASKIN1、MLST8、BRICD5、PGP 、E4F1、DNASE1L2、ECI1、RNPS1、MIR3677、MIR940、MIR4717、ABCA3、ABCA17P 、CCNF、C16orf59、NTN3、TBC1D24、ATP6V0C、AMDHD2、CEMP1、MIR3178、PDPK1、LOC652276、FLJ42627、ERVK13-1、KCTD5、PRSS27、SRRM2-AS1、SRRM2、TCEB2 、PRSS33、PRSS41、PRSS21、ZG16B、PRSS30P、PRSS22、FLYWCH2、FLYWCH1、KRE MEN2、PAQR4、PKMYT1、LINC00514、LOC100507378、CLDN9、CLDN6、TNFRSF12A 、HCFC1R1、THOC6、CCDC64B、LOC100128770、MMP25、LOC100996528、LOC1005 07419、IL32、ZSCAN10、ZNF205-AS1、ZNF205、LOC100507458、ZNF213、CASP1 6、OR1F1、OR1F2P、ZNF200、MEFV、FLJ39639、ZNF263、TIGD7、ZNF75A、OR2C1、 MTRNR2L4、ZNF434、ZNF174、ZNF597、NAA60、C16orf90、CLUAP1、NLRC3、SLX4 、DNASE1、TRAP1、CREBBP、ADCY9、SRL、LOC100507501、TFAP4、GLIS2、PAM16、C ORO7-PAM16、CORO7、VASN、DNAJA3、NMRAL1、HMOX2、CDIP1、C16orf96、FAM10 0A、MGRN1、NUDT16L1、ANKS3、C16orf71、ZNF500、SEPT12、LOC440335、ROGDI 、GLYR1、UBN1、PPL、SEC14L5、NAGPA、NAGPA-AS1、C16orf89、ALG1、FAM86A、L OC100287538、RBFOX1、LOC440337、TMEM114、METTL22、ABAT、TMEM186、PMM2、 CARHSP1、USP7、C16orf72、GRIN2A、ATF7IP2、LOC100287628、EMP2、TEKT5、N UBP1、FAM18A、CIITA、DEXI、LOC100505564、CLEC16A、SOCS1、TNP2、PRM3、PR M2, PRM1, MIR548H2, RMI2, LOC388210, LOC400499, LITAF, SNN, TXNDC11, ZC3H7A, BCAR4, RSL1D1, GSPT1, TNFRSF17, SNX29, FLJ32790, CPPED1, MIR4718SHISA9、ERCC4、MKL2、LOC100129781、MIR193B、MIR365A、PARN、BFAR、PLA2G10、LOC642778、LOC100652777、LOC642799、ABCC6P2、NOMO1、MIR3179-1、 MIR3670-1、MIR3180-1、NPIP、PDXDC1、MIR1972-1、NTAN1、RRN3、MIR3180-4、LOC100288332、MPV17L、C16orf45、KIAA0430、NDE1、MIR484、MYH11、FOPNL、ABCC1、ABCC6、NOMO3、MIR3179-2、MIR3670-2、MIR3180-2、PKD1P1、XYLT1、LOC100996242、MIR3180-3、MIR3179-3、NOMO2、ABCC6P1、RPS15A、ARL6IP1、SMG1、TMC7、COQ7、ITPRIPL2、SYT17、CLEC19A、TMC5、GDE1、CCP110、C16orf62、C16orf88、IQCK、GPRC5B、GPR139、GP2、UMOD、PDILT、ACSM5、ACSM2A、ACSM2B、ACSM1、THUMPD1、ACSM3、ERI2、LOC81691、DCUN1D3、LYRM1、DNAH3、TMEM159、ZP2、ANKS4B、CRYM、CRYM-AS1、SNX29P1、NPIPL3、LOC100190986、LOC100271836、MIR3680-1、SLC7A5P2、METTL9、IGSF6、OTOA、RRN3P1、LOC100996277、UQCRC2、PDZD9、C16orf52、VWA3A、EEF2K、POLR3E、CDR2、RRN3P3、SMG1P1、LOC100132247、LOC653786、HS3ST2、USP31、SCNN1G、SCNN1B、COG7、GGA2、EARS2、UBFD1、NDUFAB1、PALB2、DCTN5、PLK1、ERN2、CHP2、PRKCB、CACNG3、RBBP6、FLJ45256、TNRC6A、SLC5A11、ARHGAP17、LOC554206、LOC283887、LCMT1、LOC100506655、AQP8、ZKSCAN2、HS3ST4、MIR548W、C16orf82、KDM8、NSMCE1、FLJ21408、IL4R、IL21R、IL21R-AS1、GTF3C1、KIAA0556、GSG1L、XPO6、LOC100506705、SBK1、LOC728741、EIF3CL、CLN3、APOBR、IL27、NUPR1、CCDC101、SULT1A2、SULT1A1、LOC728734、EIF3C、LOC100507607、ATXN2L、TUFM、MIR4721、SH2B1、ATP2A1、LOC100289092、RABEP2、CD19、NFATC2IP、MIR4517、SPNS1、LAT、RRN3P2、SNX29P2、LOC728888、LOC606724、BOLA2、SLX1B、SLX1B-SULT1A4、SULT1A4、LOC388242、LOC440354、MIR3680-2、SLC7A5P1、SPN、QPRT、C16orf54、ZG16、KIF22、MAZ、LOC100289283、PRRT2、PAGR1、MVP、CDIPT、LOC440356、SEZ6L2、ASPHD1、KCTD13、TMEM219、TAOK2、HIRIP3、INO80E、DOC2A、C16orf92、FAM57B、LOC100996332、ALDOA、PPP4C、TBX6、YPEL3、GDPD3、MAPK3、CORO1A、BOLA2B、SLX1A、SLX1A-SULT1A3、SULT1A3、LOC613038、LOC613037、LOC595101、CD2BP2、TBC1D10B、MYLPF、SEPT1、ZNF48、ZNF771、DCTPP1、SEPHS2、ITGAL、LOC100506928、MIR4518、ZNF768、ZNF747、LOC100996344、ZNF764、ZNF688、ZNF785、ZNF689、PRR14、FBRS、LOC730183、SRCAP、SNORA30、LOC100862671、PHKG2、C16orf93、RNF40、ZNF629、MIR4519、BCL7C、MIR762、CTF1、FBXL19-AS1、FBXL19、ORAI3、SETD1A、HSD3B7、STX1B、STX4、ZNF668、ZNF646、PRSS53、VKORC1、BCKDK、KAT8、LOC100507092、LOC100996366、PRSS8、PRSS36、FUS、PYCARD、LOC100652740、TRIM72、PYDC1、ITGAM、ITGAX、ITGAD、COX6A2、ZNF843、ARMC5、TGFB1I1、SLC5A2、C16orf58、LOC100128371、AHSP、CSDAP1、KIAA0664L3、ZNF720、ZNF267、LOC729264、LOC100507221、LOC390705、TP53TG3、SLC6A10P、TP53TG3C、TP53TG3B、LOC653562、LINC00273、LOC100505948、UBE2MP1、LOC283914、LOC146481、 LOC100130700、RNA5SP411、FLJ26245、ANKRD26P1、SHCBP1、VPS35、ORC6、MY LK3、C16orf87、GPT2、DNAJA2、NETO2、ITFG1、PHKB、LOC100507534、ABCC12、A BCC11、LONP2、LOC100507577、SIAH1、N4BP1、CBLN1、C16orf78、ZNF423、CNE P1R1、HEATR3、PAPD5、ADCY7、BRD7、NKD1、LOC100996329、SNX20、NOD2、CYLD、 SALL1、LOC388276、LOC100505619、TOX3、LOC643714、CHD9、LOC643802、RBL 2、AKTIP、RPGRIP1L、FTO、FTO-IT1、LOC100996338、IRX3、LOC100996345、CRN DE、IRX5、LOC100132339、IRX6、MMP2、LPCAT2、CAPNS2、SLC6A2、CES1P2、CES 1P1、CES1、CES5A、LOC283856、GNAO1、DKFZP434H168、MIR3935、LOC10050572 2, AMFR, NUDT21, OGFOD1, BBS2, MT4, MT3, MT2A, MT1L, MT1E, MT1M, MT1JP, MT1A, MT1DP, MT1B, MT1F, MT1G, MT1H, MT1IP, MT1X, LOC100996353, NUP93, MIR1 38-2、SLC12A3、HERPUD1、CETP、NLRC5、CPNE2、FAM192A、RSPRY1、ARL2BP、PL LP、CCL22、CX3CL1、CCL17、CIAPIN1、COQ9、POLR2C、DOK4、CCDC102A、GPR114、 GPR56、GPR97、CCDC135、KATNB1、KIFC3、LOC388282、CNGB1、TEPP、ZNF319、U SB1、MMP15、C16orf80、CSNK2A2、CCDC113、PRSS54、GINS3、NDRG4、SETD6、CNO T1、SNORA46、SNORA50、SLC38A7、GOT2、LOC644649、LOC729159、CDH8、RNU6- 21、CDH11、LOC283867、CDH5、LOC100505865、BEAN1、TK2、CKLF、CKLF-CMTM1、CMTM1、CMTM2、CMTM3、CMTM4、DYNC1LI2、CCDC79、NAE1、CA7、PDP2、CDH16、RRAD、FAM96B、CES2、CES3、CES4A、CBFB、C16orf70、B3GNT9、TRADD、FBXL8、HSF 4、NOL3、KIAA0895L、EXOC3L1、E2F4、ELMO3、MIR328、LRRC29、TMEM208、FHOD1、SLC9A5、PLEKHG4、KCTD19、LRRC36、TPPP3、ZDHHC1、HSD11B2、ATP6V0D1、AG RP, LOC100505942, FAM65A, CTCF, RLTPR, ACD, PARD6A, ENKD1, C16orf86, GFOD2, RANBP10, TSNAXIP1, CENPT, THAP11, NUTF2, EDC4, NRN1L, PSKH1, CTRL, PSMB10, LCAT, SLC12A4, DPEP3, DPEP2, DDX28, DUS2L, NFATC3, ESRP2, PLA2G15, SLC7A6, SLC7A6OS, PRMT7, SMPD3, ZFP90, CDH3, CDH1, TMCO7, HAS3, CHTF8 、CIRH1A、SNTB2、VPS4A、COG8、PDF、NIP7、TMED6、TERF2、CYB5B、MIR1538、NFAT5、NQO1、NOB1、WWP2、MIR140、CLEC18A、PDXDC2P、MIR1972-2、PDPR、CLEC1 8C、LOC100506060、EXOSC6、AARS、DDX19B、LOC100506083、DDX19A、ST3GAL2、RNU6-23、FUK、COG4、SF3B3、SNORD111B、SNORD111、IL34、MTSS1L、VAC14、LO C100130894、HYDIN、FTSJD1、CALB2、ZNF23、LOC100506105、ZNF19、CHST4、LOC100132529、TAT、MARVELD3、PHLPP2、SNORA70D、LOC100996499、AP1G1、SNO RD71、ATXN1L、ZNF821、IST1、PKD1L3、DHODH、HP、HPR、TXNL4B、DHX38、PMFBP1、ZFHX3、HTA、C16orf47、LOC100506172、PSMD7、LOC283922、CLEC18B、GLG1、RFWD3、MLKL、FA2H、WDR59、ZNRF1、LDHD、ZFP1、CTRB2、CTRB1、BCAR1、CFDP1、TMEM170A、CHST6、CHST5、TMEM231、GABARAPL2、ADAT1、KARS、TERF2IP、CNTNAP4、 MIR4719, MON1B, SYCE1L, ADAMTS18, NUDT7, VAT1L, CLEC3A, WWOX, MAF, DYNLRB2, CDYL2, LOC100996425, CMC2, CENPN, ATMIN, C16orf46, GCSH, PKD1L2, BCMO1, GAN, MIR4720, CMIP, LOC100129617, PLCG2, SDR42E1, HSD17B2, MPHOSPH6, CDH13, MIR3182, HSBP1, MLYCD, OSGIN1, NECAB2, SLC38A8, MBTPS1, HSD L1、DNAAF1、TAF1C、ADAD2、LOC654780、KCNG4、WFDC1、ATP2C2、KIAA1609、COTL1、KLHL36、USP10、CRISPLD2、ZDHHC7、KIAA0513、FAM92B、LOC400548、LIN C00311、MIR5093、GSE1、GINS2、C16orf74、MIR1910、EMC8、COX4I1、IRF8、LOC100506542、LOC146513、LOC732275、FOXF1-AS1、FOXF1、MTHFSD、FLJ30679 FOXC2、FOXL1、C16orf95、FBXO31、MAP1LC3B、ZCCHC14、JPH3、LOC100129215、KLHDC4、SLC7A5、CA5A、BANP、LOC400553、LOC100506735、ZNF469、ZFPM1、M IR5189、ZC3H18、IL17C、CYBA、MVD、SNAI3-AS1、SNAI3、RNF166、CTU2、PIEZO1、MIR4722、LOC100289580、FLJ40448、CDT1、APRT、GALNS、TRAPPC2L、PABPN 1L、CBFA2T3、LOC642452、LOC100129697、LOC100506183、ACSF3、LINC00304、LOC400558、CDH15、SLC22A31、ZNF778、LOC642533、ANKRD11、LOC10028703 6、SPG7、RPL13、SNORD68、CPNE7、DPEP1、CHMP1A、C16orf55、CDK10、SPATA2L、VPS9D1、LOC100128881、ZNF276、FANCA、SPIRE2、TCF25、MC1R、TUBB3、DEF8、CENPBD1、AFG3L1P、DBNDD1、GAS8、C16orf3、LOC100130015、PRDM7、LOC1009 96541、LOC100506347、DOC2B、LOC100506371、RPH3AL、LOC100506388、C17o rf97, FAM101B, VPS53, FAM57A, GEMIN4, DBIL5P, GLOD4, RNMTL1, NXN, TIMM22, ABR, MIR3183, BHLHA9, TUSC5, YWHAE, CRK, MYO1C, INPP5K, PITPNA-AS1, PI TPNA、SLC43A2、SCARF1、RILP、PRPF8、TLCD2、MIR22HG、MIR22、WDR81、SERPI NF2、SERPINF1、SMYD4、RPA1、RTN4RL1、DPH1、OVCA2、MIR132、MIR212、HIC1、 SMG6、SRR、TSR1、SNORD91B、SNORD91A、SGSM2、MNT、LOC284009、METTL16、PA FAH1B1、KIAA0664、MIR1253、RAP1GAP2、OR1D5、OR1D2、OR1G1、LOC100288728 、OR1A2、OR1A1、OR1D4、OR3A2、OR3A1、OR3A4P、OR1E1、OR3A3、OR1E2、SPATA2 2、ASPA、TRPV3、TRPV1、SHPK、CTNS、TAX1BP3、P2RX5-TAX1BP3、EMC6、P2RX5、 ITGAE、GSG2、C17orf85、CAMKK1、P2RX1、ATP2A3、ZZEF1、CYB5D2、ANKFY1、UB E2G1、SPNS3、SPNS2、MYBBP1A、GGT6、SMTNL2、ALOX15、PELP1、ARRB2、MED11、C C17orf 107、GP1BA、SLC25A11、RNF167、PFN1、ENO3、SPAG7、CAMTA2、INCA1、KIF1C、S LC52A1、ZFP3、ZNF232、USP6、ZNF594、LOC100130950、SCIMP、RABEP1、NUP88 、RPAIN、C1QBP、DHX33、DERL2、MIS12、LOC728392、NLRP1、LOC339166、WSCD1、AIPL1、FAM64A、PITPNM3、KIAA0753、TXNDC17、MED31、C17orf100、MIR4520A、MIR4520B、ALOX15P1、SLC13A5、XAF1、FBXO39、TEKT1、ALOX12P2、LOC100506713、ALOX12、RNASEK、RNASEK-C17orf49、C17orf49、MIR497HG、MIR195、MIR497、BCL6B、SLC16A13、SLC16A11、CLEC10A、ASGR2、ASGR1、DLG4、ACADVL、MIR324、DVL2、PHF23、GABARAP、CTDNEP1、ELP5、CLDN7、SLC2A4、YBX2、EIF5A、GPS2、NEURL4、ACAP1、KCTD11、TMEM95、TNK1、PLSCR3、C17orf61-PLSCR3、C17orf61、NLGN2、SPEM1、C17orf74、LOC100996282、TMEM102、FGF11、CHRNB1、ZBTB4、SLC35G6、POLR2A、TNFSF12、TNFSF12-TNFSF13、TNFSF13、SENP3、SENP3-EIF4A1、EIF4A1、SNORA48、SNORD10、SNORA67、CD68、MPDU1、SOX15、FXR2、SHBG、SAT2、ATP1B2、TP53、WRAP53、EFNB3、DNAH2、RPL29P2、KDM6B、TMEM88、LSMD1、CYB5D1、CHD3、SCARNA21、LOC284023、KCNAB3、TRAPPC1、CNTROB、GUCY2D、ALOX15B、ALOX12B、MIR4314、ALOXE3、HES7、PER1、VAMP2、TMEM107、SNORD118、MIR4521、MIR3676、C17orf59、AURKB、LINC00324、CTC1、PFAS、SLC25A35、RANGRF、ARHGEF15、ODF4、LOC100128288、KRBA2、RPL26、RNF222、NDEL1、MYH10、CCDC42、SPDYE4、MFSD6L、PIK3R6、PIK3R5、NTN1、STX8、WDR16、USP43、DHRS7C、GLP2R、RCVRN、GAS7、MYH13、MYH8、MYH4、MYH1、MYH2、MYH3、SCO1、ADPRM、TMEM220、MAGOH2、LINC00675、PIRT、SHISA6、DNAH9、ZNF18、MAP2K4、MIR744、LINC00670、MYOCD、ARHGAP44、MIR1269B、ELAC2、HS3ST3A1、MIR548H3、CDR T15P1、COX10-AS1、COX10、CDRT15、HS3ST3B1、MGC12916、FLJ45831、CDRT7、PMP22、MIR4731、TEKT3、FAM18B2-CDRT4、CDRT4、FAM18B2、CDRT1、TRIM16、Z NF286A、TBC1D26、CDRT15P2、MEIS3P1、ADORA2B、ZSWIM7、TTC19、NCOR1、PIGL、MIR1288、CENPV、UBB、TRPV2、C17orf76-AS1、SNORD49B、SNORD49A、SNORD 65、FAM211A、ZNF287、ZNF624、CCDC144A、USP32P1、FAM106CP、KRT16P2、TBC1D27、TNFRSF13B、MPRIP、PLD6、FLCN、COPS3、NT5M、SMCR9、MED9、RASD1、PEM T, RAI1, SMCR5, SREBF1, MIR33B, TOM1L2, LOC100507131, LRRC48, ATPAF2, GID4, DRG2, MYO15A, ALKBH5, LLGL1, FLII, SMCR7, TOP3A, SMCR8, SHMT1, EVPLL, LOC339240, LGALS9C, USP32P2, FAM106A, CCDC144B, TBC1D28, ZNF286B, FOXO3B, TRIM16L, FBXW10, FAM18B1, PRPSAP2, SLC5A10, FAM83G, GRAP, SNORD 3B-1、SNORD3B-2、SNORD3D、GRAPL、LOC79999、SNORD3A、SNORD3C、LOC388436、EPN2、EPN2-IT1、EPN2-AS1、B9D1、MIR1180、MAPK7、MFAP4、RNF112、SLC47 A1、SNORA59B、ALDH3A2、SLC47A2、ALDH3A1、ULK2、AKAP10、SPECC1、LOC100131943、CCDC144C、LOC100996259、LGALS9B、KRT16P3、CDRT15L2、CCDC144NL、LOC339260、USP22、DHRS7B、TMEM11、C17orf103、MAP2K3、KCNJ12、C17orf51、FAM27L、FLJ36000、MTRNR2L1、LOC100506418、MIR4522、WSB1、TBC1D3P5、KSR1、LGALS9、NOS2、LYRM9、NLK、PYY2、PPY2、KRT18P55、TMEM97、IFT20、TNFAIP1、POLDIP2、TMEM199、MIR4723、SEBOX、VTN、SARM1、SLC46A1、SLC13A2、FOXN1、UNC119、PIGS、ALDOC、SPAG5、SPAG5-AS1、SGK494、KIAA0100、 SDF2、SUPT6H、PROCA1、RAB34、NARR、RPL23A、SNORD42B、SNORD4A、SNORD42A、SNORD4B、TLCD1、NEK8、TRAF4、FAM222B、ERAL1、MIR451A、MIR451B、MIR144、MIR4732、FLOT2、DHRS13、PHF12、SEZ6、PIPOX、MYO18A、TIAF1、CRYBA1、NUFIP2、MIR4523、TAOK1、ABHD15、TP53I13、GIT1、ANKRD13B、CORO6、SSH2、EFCAB5、NSRP1、MIR423、MIR3184、SLC6A4、BLMH、TMIGD1、CPD、GOSR1、TBC1D29、LRRC37BP1、SH3GL1P2、SUZ12P1、CRLF3、ATAD5、TEFM、ADAP2、RNF135、DPRXP4、LOC646021、MIR4733、NF1、OMG、EVI2B、EVI2A、RAB11FIP4、MIR4724、MIR193A、MIR4725、MIR365B、COPRS、UTP6、SUZ12、LRRC37B、SH3GL1P1、RHOT1、ARGFXP2、LOC100506596、RHBDL3、C17orf75、MIR632、ZNF207、PSMD11、CDK5R1、MYO1D、LOC100506629、LOC100506643、TMEM98、SPACA3、ASIC2、AA06、CCL2、CCL7、CCL11、CCL8、CCL13、CCL1、C17orf102、TMEM132E、CCT6B、ZNF830、LIG3、RAD51L3-RFFL、RFFL、RAD51D、FNDC8、NLE1、UNC45B、SLC35G3、SLFN5、SLFN11、SLFN12、SLFN13、SLFN12L、SLFN14、SNORD7、PEX12、AP2B1、RASL10B、GAS2L2、C17orf50、MMP28、TAF15、C17orf66、CCL5、RDM1、LYZL6、CCL16、CCL15-CCL14、CCL14、CCL15、CCL23、CCL18、CCL3、CCL4、TBC1D3B、CCL3L3、CCL4L1、TBC1D3C、CCL3L1、CCL4L2、TBC1D3H、TBC1D3G、ZNHIT3、MYO19、PIGW、GGNBP2、DHRS11、MRM1、LHX1、AATF、MIR2909、ACACA、C17orf78、TADA2A、DUSP14、SYNRG、DDX52、HNF1B、LOC284100、TBC1D3F、TBC1D3、LOC440434、MRPL45、GPR179、SOCS7 、ARHGAP23、SRCIN1、C17orf96、MIR4734、MLLT6、MIR4726、CISD3、PCGF2、PSMB3、PIP4K2B、CWC25、MIR4727、C17orf98、RPL23、SNORA21、LASP1、LINC0067 2、FBXO47、LOC100996526、LRRC37A11P、LOC100131347、PLXDC1、ARL5C、CACNB1、RPL19、STAC2、FBXL20、MED1、CDK12、NEUROD2、PPP1R1B、STARD3、TCAP、P NMT、PGAP3、ERBB2、MIR4728、MIEN1、GRB7、IKZF3、ZPBP2、GSDMB、ORMDL3、LRRC3C、GSDMA、PSMD3、LOC100505620、CSF3、MED24、SNORD124、THRA、NR1D1、MS L1、CASC3、RAPGEFL1、WIPF2、CDC6、RARA、GJD3、TOP2A、IGFBP4、TNS4、CCR7、SMARCE1、KRT222、KRT24、KRT25、KRT26、KRT27、KRT28、KRT10、TMEM99、KRT1 2、KRT20、KRT23、KRT39、KRT40、KRTAP3-3、KRTAP3-2、KRTAP3-1、KRTAP1-5、KRTAP1-4、KRTAP1-3、KRTAP1-1、KRTAP2-1、KRTAP2-2、KRTAP2-3、KRTAP2-4、 KRTAP4-7、KRTAP4-8、KRTAP4-9、KRTAP4-11、KRTAP4-12、KRTAP4-6、KRTAP4-5、KRTAP4-4、KRTAP4-3、KRTAP4-2、KRTAP4-1、KRTAP9-1、KRTAP9-2、KRTAP9 -3、KRTAP9-8、KRTAP9-4、KRTAP9-9、KRTAP9-6、KRTAP9-7、KRTAP16-1、KRTAP17-1、KRT33A、KRT33B、KRT34、KRT31、LOC100505782、KRT37、KRT38、KRT32、KRT35、KRT36、KRT13、KRT15、KRT19、LOC147093、KRT9、KRT14、KRT16、KRT17、KRT42P、EIF1、GAST、HAP1、JUP、LEPREL4、FKBP10、NT5C3L、KLHL10、KLHL11、ACLY、 TTC25、CNP、DNAJC7、NKIRAS2、ZNF385C、LOC100507656、DHX58、KAT2A、HSPB 9、RAB5C、KCNH4、HCRT、GHDC、STAT5B、STAT5A、STAT3、PTRF、ATP6V0A1、MIR5 48AT、MIR5010、NAGLU、HSD17B1、COASY、MLX、PSMC3IP、FAM134C、TUBG1、TUB G2、PLEKHH3、CCR10、CNTNAP1、EZH1、RAMP2-AS1、RAMP2、VPS25、WNK4、COA3、 CNTD1、BECN1、PSME3、AOC2、AOC3、AOC4、LINC00671、G6PC、PTGES3L-AARSD1 、AARSD1、PTGES3L、RUNDC1、RPL27、IFI35、VAT1、RND2、BRCA1、NBR2、NBR1、T MEM106A, TMEM106A-AS1, LOC100130581, ARL4D, MIR2117, DHX8, ETV4, MEOX1, SOST, DUSP3, C17orf105, MPP3, CD300LG, MPP2, FAM215A, LOC100996563, P PY, PYY, NAGS, TMEM101, LSM12, G6PC3, HDAC5, C17orf53, ASB16, ASB16-AS1, TMUB2, ATXN7L3, UBTF, SLC4A1, RUNDC3A, SLC25A39, GRN, FAM171A2, ITGA2 B、GPATCH8、FZD2、C17orf104、CCDC43、DBF4B、ADAM11、GJC1、HIGD1B、EFTUD 2、CCDC103、GFAP、KIF18B、C1QL1、DCAKD、NMT1、PLCD3、ACBD4、HEXIM1、HEXIM 2、FMNL1、MAP3K14-AS1、SPATA32、MAP3K14、ARHGAP27、PLEKHM1、MIR4315-1 、LRRC37A4P、LOC644172、CRHR1、MGC57346、CRHR1-IT1、MAPT-AS1、SPPL2C、 MAPT、MAPT-IT1、STH、KANSL1、KANSL1-AS1、LRRC37A、ARL17B、NSFP1、LRRC3 7A2、ARL17A、NSF、WNT3、WNT9B、GOSR2、MIR5089、RPRML、CDC27、MYL4、ITGB3、EFCAB13、MRPL45P2、NPEPPS、KPNB1、TBKBP1、TBX21、OSBPL7、MRPL10、LRRC46、SCRN2、SP6、LOC100506295、SP2、LOC100506325、PNPO、PRR15L、CDK5RAP3、COPZ2、MIR152、NFE2L1、CBX1、SNX11、SKAP1、MIR1203、HOXB1、HOXB2、HOXB-AS1、HOXB3、HOXB4、MIR10A、HOXB-AS3、HOXB5、HOXB6、HOXB7、HOXB8、HOXB9、MIR196A1、LOC100506373、PRAC、HOXB-AS5、MIR3185、HOXB13、TTLL6、CALCOCO2、ATP5G1、UBE2Z、SNF8、GIP、IGF2BP1、B4GALNT2、GNGT2、ABI3、PHOSPHO1、FLJ40194、ZNF652、PHB、NGFR、LOC100288866、NXPH3、SPOP、SLC35B1、FAM117A、KAT7、TAC4、FLJ45513、DLX4、DLX3、LOC284080、ITGA3、PDK2、SAMD14、PPP1R9B、SGCA、HILS1、COL1A1、TMEM92、XYLT2、MRPL27、EME1、LRRC59、ACSF2、CHAD、RSAD1、MYCBPAP、EPN3、SPATA20、CACNA1G-AS1、CACNA1G、ABCC3、ANKRD40、LUC7L3、LINC00483、WFIKKN2、TOB1、TOB1-AS1、LOC100506609、SPAG9、NME1-NME2、NME1、NME2、MBTD1、UTP18、FLJ42842、CA10、C17orf112、KIF2B、TOM1L1、COX11、STXBP4、HLF、MMD、TMEM100、PCTP、ANKFN1、NOG、C17orf67、DGKE、MTVR2、TRIM25、MIR3614、COIL、SCPEP1、RNF126P1、AKAP1、MSI2、MRPS23、CUEDC1、VEZF1、FLJ44342、SRSF1、DYNLL2、OR4D1、MSX2P1、OR4D2、EPX、MKS1、LPO、MPO、BZRAP1、BZRAP1-AS1、MIR142、MIR4736、SUPT4H1、RNF43、HSF5、MTMR4、SEPT4, C17orf47, TEX14, RAD51C, PPM1E, TRIM37, SKA2, MIR454, MIR301A, PRR11, SMG8, GDPD1, YPEL2, MIR4729, DHX40, CLTC, CLTC-IT1, PTRH2, VMP1, MIR21, TUBD1, RPS6KB1, RNFT1, TBC1D3P1-DHX40P1, MIR4737, HEATR6 LOC645638, LOC653653, LOC100996660, CA4, USP32, SCARNA20, LOC100506 882 C17orf64 APPBP2 PPM1D BCAS3 TBX2 C17orf82 TBX4 NACA2 BRIP1 INTS2, MED13, TBC1D3P2, EFCAB3, METTL2A, TLK2, MRC2, MARCH10, MIR633. TANC2, CYB561, ACE, KCNH6, DCAF7, TACO1, MAP3K3, LIMD2, LOC729683, STRA DA, CCDC47, DDX42, FTSJ3, PSMC5, SMARCD2, TCAM1P, CSH2, GH2, CSH1, CSHL1 GH1, CD79B, SCN4A, C17orf72, ICAM2, ERN1, SNORD104, SNORA76, TEX2, PEC AM1, MILR1, POLG2, DDX5, MIR3064, MIR5047, CEP95, SMURF2, LOC146880, PLE KHM1P, MIR4315-2, LRRC37A3, AMZ2P1, GNA13, LOC100507002, RGS9, AXIN2 CEP112, APOH, PRKCA, MIR634, CACNG5, CACNG4, CACNG1, HELZ, LOC10099636 8. PSMD12, PITPNC1, MIR548D2, MIR548AA2, NOL11, SNORA38B, BPTF, C17orf 58. KPNA2, LINC00674, LOC440461, AMZ2, ARSG, SLC16A6, WIPI1, MIR635, PRK AR1A、FAM20A、ABCA8、ABCA9、ABCA6、MIR4524B、MIR4524A、ABCA10、ABCA5、M AP2K6, KCNJ16, KCNJ2-AS1, KCNJ2, FLJ37644, SOX9, LINC00673, LINC00511 SLC39A11, SSTR2, COG1, FAM104A, C17orf80, CPSF4L, CDC42EP4, SDK2, LOC 100134391, LINC00469, LOC400620, RPL38, MGC16275, TTYH2, DNAI2, KIF19.BTBD17、GPR142、GPRC5C、CD300A、CD300LB、CD300C、CD300LD、C17orf77、CD300E、RAB37、CD300LF、SLC9A3R1、MIR3615、NAT9、TMEM104、GRIN2C、FDXR、F ADS6、USH1G、OTOP2、OTOP3、HID1、CDR2L、ICT1、ATP5H、KCTD2、LOC100996374、SLC16A5、ARMC7、NT5C、HN1、SUMO2、NUP85、GGA3、MRPS7、MIF4GD、LOC1002 87042、SLC25A19、GRB2、MIR3678、KIAA0195、CASKIN2、TSEN54、LLGL2、MYO15B、RECQL5、SMIM5、SMIM6、SAP30BP、ITGB4、GALK1、H3F3B、MIR4738、UNK、LO C100507191、UNC13D、WBP2、TRIM47、TRIM65、MRPL38、FBF1、ACOX1、TEN1-CDK3、TEN1、CDK3、EVPL、SRP68、GALR2、ZACN、EXOC7、FOXJ1、RNF157-AS1、RNF1 57, FAM100B, QRICH2, PRPSAP1, SPHK1, UBE2O, AANAT, RHBDF2, CYGB, PRCD, SNHG16, SNORD1C, SNORD1B, SNORD1A, ST6GALNAC2, ST6GALNAC1, MXRA7, JMJD6, METTL23, SRSF2, MIR636, MFSD11, MGAT5B, SEC14L1, LINC00338, SCARNA16, SEPT9, MIR4316, LOC100507351, LOC100132174, FLJ45079, TNRC6C, LOC1 00131096、TMC6、TMC8、C17orf99、SYNGR2、TK1、AFMID、BIRC5、TMEM235、LOC100996291、SOCS3、PGS1、DNAH17、LOC100996295、CYTH1、USP36、TIMP2、LOC 100653515、LGALS3BP、CANT1、LOC100507410、C1QTNF1、ENGASE、RBFOX3、MIR4739、HP09025、ENPP7、CBX2、CBX8、LOC100507425、CBX4、TBC1D16、CCDC40MIR1268B、GAA、EIF4A3、CARD14、SGSH、SLC26A11、RNF213、LOC100294362、ENDOV、LOC100507440、MIR4730、NPTX1、RPTOR、LOC100128105、FLJ46026、CHMP6、PP13、BAIAP2-AS1、BAIAP2、 AATK、MIR657、MIR3065、MIR338、MIR1250、AATK-AS1、AZI1、ENTHD2、C17orf 89、SLC38A10、LINC00482、TMEM105、LOC100130370、LOC100507520、BAHCC1、 MIR4740、MIR3186、ACTG1、FSCN2、C17orf70、NPLOC4、TSPAN10、PDE6G、OXLD 1、CCDC137、ARL16、HGS、MRPL12、SLC25A10、GCGR、FAM195B、PPP1R27、P4HB、A RHGDIA、ALYREF、ANAPC11、NPB、PCYT2、SIRT7、MAFG、MAFG-AS1、PYCR1、MYAD ML2、NOTUM、ASPSCR1、STRA13、LRRC45、RAC3、DCXR、RFNG、GPS1、DUS1L、FASN、 CCDC57、SLC16A3、CSNK1D、CD7、SECTM1、TEX19、UTS2R、OGFOD3、HEXDC、HEXD C-IT1、C17orf62、NARF、FOXK2、WDR45L、RAB40B、MIR4525、FN3KRP、FN3K、TBC D、ZNF750、B3GNTL1、METRNL、LOC100505909、FLJ43681、ROCK1P1、USP14、TH OC1、COLEC12、CETN1、CLUL1、C18orf56、TYMS、ENOSF1、YES1、ADCYAP1、LINC0 0470、LOC100652823、METTL4、NDC80、CBX3P2、SMCHD1、EMILIN2、LPIN2、LOC 727896、MYOM1、MYL12A、MYL12B、TGIF1、LOC100505592、DLGAP1、DLGAP1-AS1 、DLGAP1-AS2、DLGAP1-AS3、DLGAP1-AS5、C18orf42、LINC00526、LINC00667 、ZFP161、EPB41L3、LOC645355、MIR3976、TMEM200C、L3MBTL4、MIR4317、LOC1 00130480、ARHGAP28、LINC00668、LAMA1、LRRC30、PTPRM、LOC100192426、RAB 12、LOC100287082、SOGA2、NDUFV2、ANKRD12、TWSG1、RALBP1、PPP4R1、RAB31、TXNDC2, VAPA, APCDD1, NAPG, PIEZO2, SLC35G4, GNAL, CHMP1B, MPPE1, IMPA2, C18orf61, CIDEA, TUBB6, AFG3L2, SLMO1, SPIRE1, PSMG2, CEP76, LOC100996324, PTPN2, SEH1L, CEP192, LDLRAD4, LOC100288122, MIR5190, MIR4526, FAM210A, RNMT, MC5R, MC2R, ZNF519, ANKRD20A5P, CYP4F35P, CXADRP3, POTEC, ANKRD30B、MIR3156-2、LOC644669、ROCK1、GREB1L、ESCO1、SNRPD1、ABHD3、MIR320C1、MIB1、MIR133A1、MIR1-2、LOC100128893、GATA6、CTAGE1、RBBP8、M 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、CTDP1、KCNG2、PQLC1、HSBP1L1、TXNL4A、RBFA、LOC100506070、ADNP2、PARD 6G-AS1、PARD6G、LOC100506089、WASH5P、MIR1302-11、FAM138F、OR4F17、FLJ 45445、LOC100996328、PPAP2C、MIER2、THEG、C2CD4C、SHC2、ODF3L2、MADCAM 1、TPGS1、CDC34、GZMM、BSG、HCN2、POLRMT、FGF22、RNF126、FSTL3、PRSS57、PA LM, C19orf21, PTBP1, MIR4745, LPPR3, MIR3187, AZU1, PRTN3, ELANE, CFD, MED16, R3HDM4, KISS1R, ARID3A, WDR18, GRIN3B, C19orf6, CNN2, ABCA7, HMHA1 、POLR2E、GPX4、SBNO2、STK11、C19orf26、ATP5D、MIDN、CIRBP-AS1、CIRBP、C 19orf24、EFNA2、MUM1、NDUFS7、GAMT、DAZAP1、RPS15、APC2、C19orf25、PCSK4 、REEP6、ADAMTSL5、PLK5、MEX3D、MBD3、UQCR11、TCF3、ONECUT3、ATP8B3、REX O1、MIR1909、LOC100288123、KLF16、FAM108A1、ADAT3、SCAMP4、CSNK1G2、CSN K1G2-AS1、BTBD2、MKNK2、MOB3A、IZUMO4、AP3D1、DOT1L、PLEKHJ1、MIR1227、 SF3A2、AMH、MIR4321、JSRP1、OAZ1、C19orf35、LINGO3、LOC100129831、LSM7、 SPPL2B、TMPRSS9、TIMM13、LMNB2、GADD45B、GNG7、DIRAS1、SLC39A3、SGTA、TH OP1、ZNF554、ZNF555、ZNF556、ZNF57、ZNF77、TLE6、TLE2、AES、GNA11、GNA15、S1PR4, NCLN, CELF5, NFIC, C19orf77, DOHH, FZR1, MFSD12, C19orf71, HMG20B, GIPC3, TBXA2R, 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ZNF302、ZNF181、ZNF599、LOC400685、LOC100652909、LOC100652911、ZNF30、ZNF792、GRAMD1A、SCN1B、HPN、LOC100128675、FXYD3、LGI4、FXYD1、FXYD7、FXYD5、FAM187B、LSR、USF2、HAMP、MAG、CD22、MIR5196、FFAR1、FFAR3、LOC100128682、FFAR2、KRTDAP、DMKN、SBSN、GAPDHS、LOC100506469、TMEM147、ATP4A、HAUS5、RBM42、ETV2、COX6B1、UPK1A、UPK1A-AS1、ZBTB32、MLL4、IGFLR1、U2AF1L4、PSENEN、LIN37、HSPB6、C19orf55、ARHGAP33、PRODH2、NPHS1、KIRREL2、APLP1、NFKBID、HCST、TYROBP、LRFN3、SDHAF1、SYNE4、ALKBH6、CLIP3、THAP8、WDR62、OVOL3、POLR2I、TBCB、CAPNS1、COX7A1、ZNF565、ZNF146、LOC100134317、LINC00665、ZFP14、ZFP82、LOC644189、ZNF566、LOC728752、ZNF260、ZNF529、ZNF382、ZNF461、ZNF567、ZNF850、ZNF790-AS1、ZNF790、ZNF345、ZNF829、ZNF568、ZNF420、ZNF585A、ZNF585B、ZNF383、LOC284412、LOC100507342、HKR1、ZNF527、ZNF569、ZNF570、ZNF793、LOC400692、LOC100507433、ZNF540、ZNF571、ZFP30、ZNF781、ZNF607、LOC100507486、ZNF573、LOC644554、LOC100631378、WDR87、SIPA1L3、DPF1、PPP1R14A、SPINT2、YIF1B、C19orf33、KCNK6、CATSPERG、PSMD8、GGN、SPRED3、FAM98C、RASGRP4、RYR1、MAP4K1、EIF3K、ACTN4、CAPN12、LGALS7、LGALS7B、LGALS4、ECH1、HNRNPL、RINL、SIRT2、NFKBIB、LOC643669、SARS2、MRPS12、FBXO17、FBXO27、PAPL、PAK4、NCCRP1、SYCN、IL28B、IL28A、IL29、LRFN1、GMFG、SAMD4B、PAF1、MED29、ZFP36、MIR4530、PLEKHG2、RPS16、LOC723805、SUPT5H、TIMM50、DLL3、SELV、EID2B、EID2、LGALS13、LOC100129935、LGALS16、LGALS17A、LGALS14、CLC、LEUTX、DYRK1B、FBL、FCGBP、PSMC4、ZNF546、ZNF780B、ZNF780A、MAP3K10、TTC9B、CNTD2、AKT2、LOC100507646、MIR641、C19orf47、PLD3、HIPK4、PRX、SERTAD1、SERTAD3、BLVRB、SPTBN4、SHKBP1、LTBP4、NUMBL、ADCK4、ITPKC、C19orf54、SNRPA、MIA、MIA-RAB4B、RAB4B、RAB4B-EGLN2、EGLN2、CYP2A6、CYP2A7、CYP2G1P、CYP2B7P1、CYP2B6、CYP2A13、CYP2F1、CYP2S1、AXL、HNRNPUL1、CCDC97、TGFB1、B9D2、TMEM91、EXOSC5、BCKDHA、B3GNT8、ATP5SL、C19orf69、LOC100505495、CEACAM21、CEACAM4、CEACAM7、CEACAM5、CEACAM6、CEACAM3、LYPD4、DMRTC2、RPS19、CD79A、ARHGEF1、LOC100505585、RABAC1、ATP1A3、GRIK5、ZNF574、POU2F2、LOC100505622、MIR4323、DEDD2、ZNF526、GSK3A、LOC100132272、ERF、LOC100652741、CIC、PAFAH1B3、PRR19、TMEM145、MEGF8、CNFN、LOC100996307、LIPE、CXCL17、CEACAM1、CEACAM8、PSG3、PSG8、LOC100289650、PSG10P、PSG1、PSG6、PSG7、PSG11、PSG2、PSG5、PSG4、LOC284344、PSG9、PRG1、CD177、TEX101、LYPD3、PHLDB3、ETHE1、ZNF575、XRCC1、PINLYP、IRGQ、ZNF576、ZNF428、SRRM5、CADM4、PLAUR、IRGC、SMG9、KCNN4、LYPD5、ZNF283、ZNF404、LOC100505715、ZNF45、ZNF221、 ZNF155、ZNF230、ZNF222、ZNF223、ZNF284、ZNF224、LOC100379224、ZNF225、 ZNF234、ZNF226、ZNF227、ZNF233、ZNF235、ZFP112、ZNF285、ZNF229、ZNF180 、CEACAM20、CEACAM22P、IGSF23、PVR、MIR4531、CEACAM19、CEACAM16、BCL3、 CBLC、BCAM、PVRL2、TOMM40、APOE、APOC1、APOC1P1、APOC4-APOC2、APOC4、APO C2、CLPTM1、RELB、CLASRP、ZNF296、GEMIN7、PPP1R37、NKPD1、TRAPPC6A、BLO C1S3、EXOC3L2、MARK4、CKM、KLC3、ERCC2、PPP1R13L、CD3EAP、ERCC1、FOSB、RT N2、PPM1N、VASP、OPA3、GPR4、EML2、MIR330、LOC100287177、GIPR、MIR642A、 MIR642B、SNRPD2、QPCTL、FBXO46、LOC388553、SIX5、DMPK、DMWD、RSPH6A、SYM PK、FOXA3、IRF2BP1、MYPOP、NANOS2、NOVA2、CCDC61、MIR769、PGLYRP1、IGFL 4、IGFL3、IGFL2、DKFZp434J0226、IGFL1、HIF3A、PPP5C、CCDC8、PNMAL1、PPP5 D1, PNMAL2, CALM3, PTGIR, GNG8, DACT3, DACT3-AS1, PRKD2, MIR320E, STRN4, FKRP, SLC1A5, SNAR-E, AP2S1, ARHGAP35, NPAS1, TMEM160, ZC3H4, SAE1, BBC 3、MIR3190、MIR3191、CCDC9、PRR24、C5AR1、GPR77、DHX34、MEIS3、SLC8A2、K PTN、NAPA-AS1、NAPA、ZNF541、GLTSCR1、EHD2、GLTSCR2、SNORD23、SEPW1、TPR X1, CRX, SULT2A1, SNAR-A12, SNAR-C5, SNAR-A1, SNAR-A3, SNAR-C2, SNAR-A 2、SNAR-C4、SNAR-A13、SNAR-C3、SNAR-C1、BSPH1、ELSPBP1、CABP5、PLA2G4C、LOC100505754、LIG1、C19orf68、CARD8、LOC100505812、ZNF114、CCDC114、E MP3、TMEM143、SYNGR4、KDELR1、GRIN2D、GRWD1、KCNJ14、CYTH2、LMTK3、SULT 2B1, FAM83E, SPACA4, RPL18, SPHK2, DBP, CA11, SEC1P, NTN5, FUT2, MAMSTR, RASIP1, IZUMO1, FUT1, FGF21, BCAT2, HSD17B14, PLEKHA4, PPP1R15A, TULP2 NUCB1, DHDH, BAX, FTL, GYS1, RUVBL2, LHB, CGB, SNAR-G2, CGB2, CGB1, SNAR-G1, CGB5, CGB8, CGB7, NTF4, KCNA7, SNRNP70, LIN7B, C19orf73, PPFIA3, HR C、TRPM4、SLC6A16、MIR4324、CD37、TEAD2、DKKL1、CCDC155、PTH2、LOC10050 7003、SLC17A7、PIH1D1、ALDH16A1、FLT3LG、RPL13A、SNORD32A、SNORD33、SNO RD34、SNORD35A、RPS11、SNORD35B、MIR150、FCGRT、RCN3、NOSIP、PRRG2、PRR 12、RRAS、SCAF1、IRF3、BCL2L12、PRMT1、MIR5088、ADM5、CPT1C、TSKS、AP2A1 、FUZ、MED25、PTOV1-AS1、PTOV1、MIR4749、PNKP、AKT1S1、TBC1D17、MIR4750 、IL4I1、NUP62、ATF5、MIR4751、SIGLEC11、SIGLEC16、VRK3、ZNF473、FLJ268 50, SNAR-A4, SNAR-A14, SNAR-A5, SNAR-A6, SNAR-A7, SNAR-A8, SNAR-A9, SNAR-A10, SNAR-A11, SNAR-B1, SNAR-B2, SNAR-D, IZUMO2, MYH14, KCNC3, NAPS B、NAPSA、NR1H2、POLD1、SPIB、MYBPC2、FAM71E1、EMC10、LOC100506114、JOS D2、ASPDH、LRRC4B、SNAR-F、SYT3、C19orf81、SHANK1、CLEC11A、GPR32、ACPT、C19orf48、SNORD88B、SNORD88A、SNORD88C、MGC45922、KLK1、KLK15、KLK3、KLK2、KLKP1、KLK4、LOC390956、KLK5、KLK6、KLK7、KLK8、KLK9、KLK10、KLK11、 KLK12、KLK13、KLK14、CTU1、SIGLEC9、SIGLEC7、SIGLEC17P、CD33、SIGLECL1、IGLON5、VSIG10L、ETFB、CLDND2、NKG7、LIM2、LOC147646、SIGLEC10、LOC100129083、SIGLEC8、CEACAM18、SIGLEC12、SIGLEC6、ZNF175、FLJ30403、SIGLEC5、SIGLEC14、MIR99B、MIRLET7E、MIR125A、LINC00085、HAS1、FPR1、FPR2、FPR3、ZNF577、ZNF649、ZNF613、ZNF350、ZNF615、ZNF614、ZNF432、ZNF841、ZNF616、ZNF83、ZNF836、PPP2R1A、ZNF766、MIR643、ZNF480、ZNF610、ZNF880、ZNF528、ZNF534、ZNF578、ZNF808、ZNF701、ZNF137P、ZNF611、ZNF600、ZNF28、ZNF468、ZNF320、ZNF816-ZNF321P、ZNF321P、ZNF816、ZNF702P、ERVV-1、ERVV-2、ZNF160、ZNF415、ZNF347、ZNF665、ZNF677、VN1R2、VN1R4、FAM90A27P、BIRC8、ZNF845、ZNF525、ZNF765、TPM3P9、ZNF761、ZNF813、ZNF331、LOC284379、DPRX、MIR512-1、MIR512-2、MIR1323、MIR498、MIR520E、MIR515-1、MIR519E、MIR520F、MIR515-2、MIR519C、MIR1283-1、MIR520A、MIR526B、MIR519B、MIR525、MIR523、MIR518F、MIR520B、MIR518B、MIR526A1、MIR520C、MIR518C、MIR524、MIR517A、MIR519D、MIR521-2、MIR520D、MIR517B、MIR520G、MIR516B2、MIR526A2、MIR518E、MIR518A1、MIR518D、MIR516B1、MIR518A2、MIR517C、MIR520H、MIR521-1、MIR522、MIR519A1、MIR527、MIR516A1、MIR1283-2、MIR516A2、MIR519A2、MIR371A、MIR371B、MIR372、MIR373、NLRP12、MYADM、PRKCG、CACNG7、CACNG8、MIR935、CACNG6、VSTM1、TARM1、OSCAR、NDUFA3、TFPT、PRPF31、CN OT3、LENG1、TMC4、MBOAT7、TSEN34、RPS9、LILRB3、LILRA6、LILRB5、LILRB2、MIR4752、LILRA3、LILRA5、LILRA4、LAIR1、TTYH1、LENG8、LENG9、CDC42EP5、L AIR2, KIR3DX1, LILRA2, LILRA1, LILRB1, LILRB4, LILRP2, KIR3DL3, KIR2DL3, KIR2DL1, KIR2DL4, KIR3DL1, KIR2DS4, KIR3DL2, FCAR, NCR1, NLRP7, NLRP2, GP6, RDH13, EPS8L1, PPP1R12C, TNNT1, TNNI3, DNAAF3, SYT5, PTPRH, TMEM86B, PPP6R1, HSPBP1, BRSK1, TMEM150B, SUV420H2, COX6B2, FAM71E2, IL11, TM EM190、TMEM238、RPL28、UBE2S、SHISA7、ISOC2、ZNF628、NAT14、SSC5D、SBK2、SGK110、ZNF579、FIZ1、ZNF524、ZNF865、ZNF784、ZNF580、ZNF581、CCDC106、 U2AF2、EPN1、NLRP9、RFPL4A、LOC729974、NLRP11、NLRP4、NLRP13、NLRP8、NLRP5、ZNF787、ZNF444、GALP、ZSCAN5B、ZSCAN5A、ZSCAN5D、LOC100506374、ZNF 542、ZNF582、ZNF582-AS1、ZNF583、ZNF667、LOC100128252、ZNF471、ZFP28、ZNF470、ZNF71、LOC147670、ZNF835、ZIM2、PEG3、PEG3-AS1、MIMT1、USP29、ZI M3、DUXA、ZNF264、AURKC、ZNF805、LOC100996417、ZNF460、ZNF543、ZNF304、TRAPPC2P1、ZNF547、ZNF548、ZNF17、ZNF749、VN1R1、ZNF772、ZNF419、ZNF773ZNF549、ZNF550、ZNF416、ZIK1、ZNF530、ZNF134、ZNF211、ZSCAN4、ZNF551、ZNF154、ZNF671、ZNF776、ZNF586、ZNF552、FKBP1AP1、ZNF587B、ZNF587、ZNF814、ZNF417、 ZNF418、ZNF256、C19orf18、ZNF606、LOC100128398、ZSCAN1、ZNF135、ZSCAN18、ZNF329、ZNF274、ZNF544、ZNF8、ZSCAN22、A1BG、A1BG-AS1、ZNF497、ZNF837、MIR4754、RPS5、LOC646862、LOC100506634、ZNF584、ZNF132、ZNF324B、ZNF324、ZNF446、SLC27A5、ZBTB45、TRIM28、CHMP2A、UBE2M、LOC100131691、MZF1、MGC2752、FAM110C、SH3YL1、ACP1、FAM150B、LOC727944、LOC100996637、TMEM18、LOC339822、SNTG2、TPO、PXDN、MYT1L、LOC730811、TSSC1、TRAPPC12、ADI1、LOC100506014、RNASEH1、LOC100506054、RPS7、COLEC11、ALLC、DCDC2C、LOC100505964、LOC100996394、LOC727982、SOX11、LOC150622、LOC400940、LOC100506216、LINC00487、CMPK2、RSAD2、RNF144A-AS1、RNF144A、LOC100506274、LOC339788、LINC00299、LOC100506299、LOC100996537、ID2、KIDINS220、MBOAT2、LOC100506317、ASAP2、ITGB1BP1、CPSF3、IAH1、ADAM17、YWHAQ、LOC100996549、TAF1B、GRHL1、KLF11、CYS1、RRM2、C2orf48、MIR4261、HPCAL1、ODC1、SNORA80B、LOC100996551、NOL10、ATP6V1C2、PDIA6、KCNF1、FLJ33534、C2orf50、PQLC3、ROCK2、LINC00570、E2F6、GREB1、MIR4429、NTSR2、LPIN1、LOC100506405、MIR548S、MIR4262、LOC100506457、MIR3681、TRIB2、MIR3125、LOC100506474、FAM84A、NBAS、DDX1、MYCNOS、MYCN、FAM49A、RAD51AP2、VSNL1、SMC6、GEN1、MSGN1、KCNS3、RDH14、NT5C1B-RDH14、NT5C1B、MIR4757、 OSR1、FLJ12334、TTC32、WDR35、MATN3、LAPTM4A、SDC1、LOC100131373、PUM2 、RHOB、HS1BP3、GDF7、C2orf43、APOB、LOC100507562、LOC645949、KLHL29、A TAD2B、UBXN2A、MFSD2B、C2orf44、FKBP1B、SF3B14、TP53I3、PFN4、FAM228B、F AM228A、ITSN2、LOC100507630、NCOA1、PTRHD1、CENPO、ADCY3、DNAJC27、DNA JC27-AS1、EFR3B、POMC、DNMT3A、MIR1301、LOC100131510、DTNB、ASXL2、KIF 3C, RAB10, FAM59B, HADHA, HADHB, GPR113, EPT1, CCDC164, OTOF, C2orf70, CIB4, KCNK3, C2orf18, CENPA, DPYSL5, MAPRE3, TMEM214, AGBL5, OST4, EMILIN 1、KHK、CGREF1、ABHD1、PREB、C2orf53、TCF23、SLC5A6、ATRAID、CAD、SLC30A 3、DNAJC5G、TRIM54、UCN、MPV17、GTF3C2、LOC100505624、EIF2B4、SNX17、ZN F513、PPM1G、FTH1P3、NRBP1、KRTCAP3、IFT172、FNDC4、GCKR、C2orf16、ZNF5 12、CCDC121、GPN1、SUPT7L、SLC4A1AP、MRPL33、RBKS、BRE-AS1、BRE、MIR4263 、LOC100505716、FLJ31356、FOSL2、PLB1、LOC100505774、PPP1CB、SPDYA、TR MT61B、WDR43、SNORD92、SNORD53、FAM179A、C2orf71、CLIP4、ALK、YPEL5、LB H、LCLAT1、CAPN13、GALNT14、LOC100652774、CAPN14、EHD3、XDH、SRD5A2、ME MO1、DPY30、HP11026、SPAST、SLC30A6、NLRC4、YIPF4、BIRC6、MIR558、TTC27、MIR4765, LINC00486, LOC100271832, LTBP1, MIR4430, RASGRP3, FAM98A, MYADML, MIR548AD, LOC100288911, CRIM1, FEZ2, VIT, STRN, HEATR5B, CCDC75, EIF2AK2, SULT6B1, LOC100505876, CEBPZ, NDUFAF7, PRKD3, QPCT, CDC42EP3, FAM82A1, CYP1B1, CYP1B1-AS1, ATL2, HNRPLL, GALM, SRSF7, GEMIN6, DHX57, MORN2, ARHGEF33, L OC375196、SOS1、CDKL4、MAP4K3、LOC728730、TMEM178A、THUMPD2、SLC8A1-A S1、SLC8A1、LOC388942、C2orf91、PKDCC、EML4、COX7A2L、KCNG3、LOC1001309 21, MTA3, OXER1, HAAO, LOC100506047, ZFP36L2, LOC100129726, THADA, PLEKHH2, LOC728819, DYNC2LI1, ABCG5, ABCG8, LRPPRC, PPM1B, SLC3A1, PREPL, C AMKMT、LOC100130502、LOC100506088、SIX3-AS1、SIX3、SIX2、UNQ6975、SRB D1、PRKCE、EPAS1、TMEM247、ATP6V1E2、RHOQ、PIGF、CRIPT、SOCS5、LOC388948 、LOC100134259、MCFD2、TTC7A、C2orf61、CALM2、BCYRN1、EPCAM、MIR559、MS H2、KCNK12、MSH6、FBXO11、LOC100506235、FOXN2、PPP1R21、STON1-GTF2A1L、 STON1、GTF2A1L、LHCGR、FSHR、NRXN1、LOC100506300、MIR4431、ASB3、GPR75 -ASB3、CHAC2、ERLEC1、MIR3682、GPR75、PSME4、ACYP2、TSPYL6、C2orf73、SPT BN1, RPL23AP32, EML6, RTN4, CLHC1, RPS27A, MTIF2, PRORSD1P, CCDC88A, CCDC104, SMEK2, PNPT1, EFEMP1, MIR217, MIR216A, MIR216B, CCDC85A, VRK2, FA NCL、FLJ30838、MIR4432、LOC100506891、BCL11A、LOC100506934、PAPOLG、F LJ16341、REL、PUS10、PEX13、KIAA1841、LOC339803、C2orf74、AHSA2、USP34、SNORA70B、XPO1、FAM161A、CCT4、COMMD1、B3GNT2、MIR5192、TMEM17、EHBP1、 LOC100132215、OTX1、DBIL5P2、WDPCP、MDH1、UGP2、VPS54、PELI1、LINC0030 9, MIR4433, LGALSL, AFTPH, MIR4434, LOC339807, SERTAD2, LOC400958, SLC1A4, CEP68, RAB1A, ACTR2, SPRED2, MIR4778, MEIS1-AS3, MEIS1, LOC1005070 73、LOC644838、ETAA1、C1D、WDR92、PNO1、PPP3R1、CNRIP1、PLEK、FBXO48、AP LF、PROKR1、ARHGAP25、LOC100996448、BMP10、GKN2、GKN1、ANTXR1、MIR3126、 GFPT1、NFU1、AAK1、SNORA36C、ANXA4、GMCL1、SNRNP27、MXD1、ASPRV1、PCBP1 -AS1、PCBP1、LOC100133985、C2orf42、TIA1、MIR1285-2、PCYOX1、SNRPG、FAM 136A、TGFA、ADD2、FIGLA、CLEC4F、CD207、VAX2、ATP6V1B1、ANKRD53、TEX261 、OR7E91P、NAGK、MCEE、MPHOSPH10、PAIP2B、ZNF638、ZNF638-IT1、DYSF、CYP2 6B1、EXOC6B、SPR、EMX1、SFXN5、RAB11FIP5、NOTO、SMYD5、PRADC1、CCT7、FBX O41、EGR4、ALMS1、NAT8、ALMS1P、NAT8B、TPRBB、DUSP11、C2orf78、STAMBP、LO C100652991、ACTG2、DGUOK、DGUOK-AS1、TET3、BOLA3、BOLA3-AS1、MOB1A、MT HFD2、SLC4A5、DCTN1、DCTN1-AS1、C2orf81、WDR54、RTKN、INO80B-WBP1、INO8 0B、WBP1、MOGS、MRPL53、CCDC142、TTC31、LBX2、LBX2-AS1、PCGF1、TLX2、DQX 1、AUP1、HTRA2、LOXL3、DOK1、C2orf65、SEMA4F、HK2、POLE4、TACR1、MIR5000、EVA1A、MRPL19、GCFC2、LRRTM4、SNAR-H、REG3G、REG1B、REG1A、REG1P、REG3A、CTNNA2、MIR4264、LRRTM1、LOC100507201、LOC1720、FUNDC2P2、 SUCLG1, DNAH6, TRABD2A, TMSB10, KCMF1, LOC100996478, TCF7L1, TGOLN2, RETSAT, ELMOD3, CAPG, SH2D6, LOC100630918, MAT2A, GGCX, VAMP8, VAMP5, RNF181, TMEM150A, USP39, C2orf68, SFTPB, GNLY, ATOH8, LOC284950, ST3GAL5, LOC90784, POLR1A, PTCD3, SNORD94, IMMT, MIR4779, MRPL35, REEP1, KDM3A, CHMP3、RNF103-CHMP3、RNF103、RMND5A、CD8A、CD8B、ANAPC1P1、RGPD1、PLGLB1、LOC285074、MIR4771-1、LINC00152、MIR4435-1、LOC730268、PLGLB2、RG PD2、KRCC1、SMYD1、MIR4780、FABP1、THNSL2、FOXI3、TEX37、EIF2AK3、RPIA、ANKRD36BP2、MIR4436A、LOC654342、LOC100506191、GGT8P、ACTR3BP2、LOC90 499、ANKRD20A8P、LOC442028、TEKT4、MAL、MRPS5、ZNF514、ZNF2、PROM2、KCNIP3、FAHD2A、TRIM43B、TRIM43、LINC00342、FAHD2CP、GPAT2、ADRA2B、ASTL DUSP2、STARD7、LOC285033、TMEM127、CIAO1、SNRNP200、ITPRIPL1、NCAPH、NEURL3、ARID5A、LOC100996535、KANSL3、FER1L5、LMAN2L、CNNM4、MIR3127、LO C100506036、CNNM3、ANKRD23、ANKRD39、SEMA4C、FAM178B、FAHD2B、ANKRD36、LOC100506076、LOC100506123、ANKRD36B、COX5B、ACTR1B、LOC728537、ZAP 70、TMEM131、VWA3B、CNGA3、INPP4A、COA5、UNC50、MGAT4A、KIAA1211L、TSGA10、C2orf15、LIPT1、MITD1、MRPL30、LYG2、LYG1、TXNDC9、EIF5B、REV1、AFF3、LOC150577、LONRF2、CHST10、NMS、PDCL3、NPAS2、RPL31、TBC1D8、LOC100506286、C2orf29、SNORD89、RNF149、MIR5696、CREG2、RFX8、MAP4K4、LOC100506328、IL1R2、LOC100131131、IL1R1、IL1RL2、IL1RL1、IL18R1、IL18RAP、MIR4772、SLC9A4、SLC9A2、MFSD9、TMEM182、LOC100287010、LOC150568、LOC284998、LOC100506421、POU3F3、LOC100128131、MRPS9、GPR45、TGFBRAP1、LOC100506473、C2orf49、FHL2、LOC285000、NCK2、C2orf40、UXS1、PLGLA、RGPD3、ST6GAL2、LOC729121、RGPD4、SLC5A7、SULT1C3、SULT1C2、SULT1C2P1、SULT1C4、GCC2、LIMS1、RANBP2、CCDC138、EDAR、SH3RF3-AS1、SH3RF3、MIR4265、MIR4266、LOC729164、SEPT10、SOWAHC、LOC100506563、RGPD5、LIMS3、LIMS3-LOC440895、LOC440895、LOC440894、MIR4267、MALL、MIR4436B1、NPHP1、LINC00116、LOC100507334、MIR4436B2、LOC151009、LOC100288570、LIMS3L、RGPD6、LOC100507581、BUB1、ACOXL、FLJ44006、BCL2L11、LOC100505634、LOC100128130、MIR4435-2、LOC541471、ANAPC1、MIR4771-2、MERTK、TMEM87B、FBLN7、ZC3H8、ZC3H6、RGPD8、TTL、POLR1B、CHCHD5、FLJ42351、SLC20A1、CKAP2L、IL1A、IL1B、IL37、IL36G、IL36A、IL36B、IL36RN、IL1F10、IL1RN、PSD4、PAX8、LOC654433、CBWD2、FOXD4L1、FAM138B、MIR1302-3、WASH2P、DDX11L2、RPL23AP7、RABL2A、LOC100506748、SLC35F5、MIR4782、ACTR3、LOC100499194、LOC440900、DPP10、LOC389023、DDX18、CCDC93、INSIG2、LOC100506797、EN1、MARCO、C1QL2、 STEAP3、C2orf76、DBI、TMEM37、SCTR、PCDP1、TMEM177、PTPN4、EPB41L5、TME M185B、RALB、INHBB、LOC84931、GLI2、TFCP2L1、CLASP1、RNU4ATAC、LOC25412 8、MKI67IP、TSN、CNTNAP5、GYPC、LOC339760、BIN1、CYP27C1、ERCC3、MAP3K2 、LOC100506922、PROC、MIR4783、LOC100131492、IWS1、MYO7B、LIMS2、GPR17、 SFT2D3、WDR33、POLR2D、AMMECR1L、SAP130、UGGT1、HS6ST1、LOC151121、LOC 389033、LOC100131320、RAB6C、LOC440905、POTEF、CCDC74B-AS1、CCDC74B、S MPD4、MZT2B、TUBA3E、CCDC115、IMP4、PTPN18、LOC100216479、CYP4F43P、PO TEI、CFC1B、LOC646743、TISP43、CFC1、POTEJ、CYP4F30P、LOC100288897、GPR 148、FAM123C、ARHGEF4、FAM168B、PLEKHB2、POTEE、LOC440910、WTH3DI、LOC 389043、LOC401010、TUBA3D、MZT2A、MIR4784、LOC150776、CCDC74A、POTEKP、 LOC100507474、LOC100507460、C2orf27A、C2orf27B、ANKRD30BL、MIR663B、 ZNF806、AZFP、FAM201B、GPR39、LYPD1、NCKAP5、LOC100996685、MIR3679、MGA T5、TMEM163、ACMSD、MIR5590、LOC100129961、CCNT2、MAP3K19、RAB3GAP1、Z RANB3、R3HDM1、MIR128-1、UBXN4、LCT、LOC100507600、MCM6、DARS、CXCR4、TH SD7B、HNMT、SPOPL、NXPH2、LOC647012、LRP1B、KYNU、ARHGAP15、GTDC1、ZEB2 、ZEB2-AS1、DKFZp686O1327、LOC100505498、PABPC1P2、ACVR2A、ORC4、MBD5、EPC2、KIF5C、LYPD6B、LYPD6、MMADHC、FLJ32955、RND3、RBM43、NMI、TNFAIP6、MIR4773-1、MIR4773-2、RIF1、NEB、ARL5A、CACNB4、STAM2、FMNL2、PRPF40A、ARL6IP6、RPRM、GALNT13、LOC100144595、KCNJ3、NR4A2、GPD2、GALNT5、ERMN、FAM133DP、CYTIP、ACVR1C、ACVR1、UPP2、CCDC148-AS1、CCDC148、PKP4、DAPL1、TANC1、WDSUB1、BAZ2B、MARCH7、LY75-CD302、CD302、LY75、PLA2R1、ITGB6、RBMS1、MIR4785、TANK、LOC100996579、PSMD14、TBR1、SLC4A10、DPP4、GCG、FAP、IFIH1、GCA、KCNH7、FIGN、GRB14、COBLL1、SNORA70F、SLC38A11、SCN3A、SCN2A、CSRNP3、GALNT3、LOC100506124、TTC21B、LOC100506134、SCN1A、SCN9A、SCN7A、XIRP2、B3GALT1、STK39、CERS6、MIR4774、CERS6-AS1、NOSTRIN、SPC25、G6PC2、ABCB11、DHRS9、LRP2、BBS5、KBTBD10、FASTKD1、PPIG、CCDC173、PHOSPHO2、PHOSPHO2-KLHL23、KLHL23、SSB、METTL5、UBR3、MYO3B、LOC440925、SP5、LOC100505695、ERICH2、GAD1、GORASP2、TLK1、METTL8、DCAF17、CYBRD1、DYNC1I2、SLC25A12、HAT1、METAP1D、DLX1、DLX2、ITGA6、PDK1、RAPGEF4-AS1、RAPGEF4、ZAK、MLK7-AS1、CDCA7、SP3、LOC100128905、OLA1、LOC285084、SP9、CIR1、SCRN3、GPR155、WIPF1、H3F3AP4、CHRNA1、CHN1、ATF2、MIR933、ATP5G3、KIAA1715、EVX2、HOXD13、HOXD12、HOXD11、HOXD10、HOXD9、HOXD8、HOXD-AS2、MIR10B、HOXD4、HOXD3、HOXD-AS1、HOXD1、MTX2、MIR1246、LOC375295、HNRNPA3、MIR4444-1、NFE2L2、MIR3128、LOC100130691、AGPS、TTC30B、TTC30A、 PDE11A、RBM45、OSBPL6、PRKRA、DFNB59、FKBP7、PLEKHA3、TTN-AS1、TTN、CCDC141、SESTD1、ZNF385B、MIR1258、CWC22、UBE2E3、MIR4437、ITGA4、CERKL、N EUROD1、SSFA2、PPP1R1C、PDE1A、DNAJC10、FRZB、NCKAP1、DUSP19、NUP35、MIR548AE1、ZNF804A、LOC100506923、FSIP2、ZC3H15、ITGAV、FAM171B、ZSWIM2 CALCRL, TFPI, GULP1, MIR561, DIRC1, COL3A1, MIR1245A, MIR1245B, MIR3606, COL5A2, MIR3129, WDR75, SLC40A1, ASNSD1, ANKAR, OSGEPL1, ORMDL1, PMS1, MSTN, C2orf88, HIBCH, INPP1, MFSD6, TMEM194B, NAB1, GLS, STAT1, STAT4, MYO1B, NABP1, SDPR, TMEFF2, LOC100506993, PCGEM1, SLC39A10, DNAH7, STK 17B、HECW2、CCDC150、LOC100130452、GTF3C3、C2orf66、PGAP1、ANKRD44、SF3B1、COQ10B、HSPD1、HSPE1、HSPE1-MOB4、MOB4、RFTN2、MARS2、BOLL、PLCL1 SATB2、SATB2-AS1、FONG、C2orf69、TYW5、C2orf47、SPATS2L、KCTD18、SGOL2、AOX1、AOX2P、LOC100507140、BZW1、RNU6-6、CLK1、PPIL3、NIF3L1、ORC2、FAM 126B、NDUFB3、CFLAR、CFLAR-AS1、CASP10、CASP8、ALS2CR12、TRAK2、STRADB、ALS2CR11、TMEM237、MPP4、ALS2、CDK15、FZD7、LOC100652824、LOC729224 SUMO1、NOP58、SNORD70、SNORD11B、SNORD11、BMPR2、FAM117B、ICA1L、WDR12、ALS2CR8、NBEAL1、CYP20A1、ABI2、RAPH1、CD28、CTLA4、ICOS、PARD3B、NRP2、INO80D、GCSHP3、NDUFS1、EEF1B2、SNORD51、SNORA41、GPR1、ZDBF2、ADAM23、 LOC200726、DYTN、MDH1B、FASTKD2、MIR3130-2、MIR3130-1、CPO、KLF7、MIR2 355、MIR1302-4、CREB1、METTL21A、CCNYL1、MIR4775、FZD5、PLEKHM3、LOC10 0507443、CRYGD、CRYGC、CRYGB、CRYGA、C2orf80、IDH1、IDH1-AS1、PIKFYVE、 PTH2R, MAP2, UNC80, RPE, KANSL1L, ACADL, MYL1, LANCL1, CPS1, CPS1-IT1, E RBB4、MIR548F2、MIR4776-1、MIR4776-2、IKZF2、LOC100130451、SPAG16、MI R4438、VWC2L、VWC2L-IT1、BARD1、ABCA12、ATIC、FN1、LINC00607、MREG、PEC R、TMEM169、XRCC5、PKI55、MARCH4、SMARCAL1、LOC100507554、RPL37A、IGFB P2, IGFBP5, TNP1, DIRC3, TNS1, RUFY4, CXCR2P1, CXCR2, CXCR1, ARPC2, GPBA R1, AAMP, PNKD, TMBIM1, C2orf62, SLC11A1, CTDSP1, MIR26B, VIL1, USP37, R QCD1、PLCD4、ZNF142、BCS1L、RNF25、STK36、TTLL4、CYP27A1、PRKAG3、WNT6、 WNT10A, CDK5R2, LINC00608, FEV, CRYBA2, MIR375, LOC100129175, CCDC108 、IHH、MIR3131、NHEJ1、SLC23A3、CNPPD1、FAM134A、ZFAND2B、ABCB6、ATG9A、 ANKZF1, GLB1L, STK16, TUBA4A, TUBA4B, DNAJB2, PTPRN, MIR153-1, RESP18 DNPEP, DES, SPEG, LOC100996693, GMPPA, ASIC4, CHPF, TMEM198, MIR3132, O BSL1, INHA, STK11IP, SLC4A3, MIR4268, EPHA4, LOC729770, PAX3, CCDC140LOC440934, SGPP2, FARSB, MOGAT1, ACSL3, KCNE4, SCG2, AP1S3, WDFY1, MRPL44, SERPINE2, FAM124B, CUL3, DOCK10, MIR4439, NYAP2, LOC646736, MIR5702, IRS1 HBDD1、COL4A4、COL4A3、MFF、TM4SF20、MIR5703、AGFG1、C2orf83、SLC19A3、 CCL20、WDR69、SPHKAP、PID1、DNER、TRIP12、FBXO36、SLC16A14、SP110、SP14 0、SP140L、SP100、LOC151475、CAB39、ITM2C、LOC151484、GPR55、LOC348761 、SPATA3、C2orf72、PSMD1、HTR2B、ARMC9、MIR4777、B3GNT7、NCL、LOC100996 253、SNORA75、SNORD20、SNORD82、LINC00471、NMUR1、C2orf57、PTMA、MIR12 44-1、PDE6D、COPS7B、MIR1471、NPPC、DIS3L2、MIR562、ALPP、ECEL1P2、ALPP L2, ALPI, ECEL1, PRSS56, CHRND, CHRNG, TIGD1, MIR5001, EIF4E2, EFHD1, GIGYF2, KCNJ13, C2orf82, NGEF, NEU2, INPP5D, ATG16L1, SCARNA5, SCARNA6, SA G、DGKD、USP40、UGT1A8、UGT1A10、UGT1A9、UGT1A7、UGT1A6、UGT1A5、UGT1A4 、UGT1A3、DNAJB3、LOC100286922、UGT1A1、HEATR7B1、HJURP、MSL3P1、TRPM8 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3、MIR2467、FLJ45964、LOC150935、MIR4786、NDUFA10、OR6B2、PRR21、OR6B3、MYEOV2、OTOS、GPC1、PP14571、MIR149、ANKMY1、DUSP28、RNPEPL1、CAPN10、GPR35、AQP12B、AQP12A、KIF1A、AGXT、C2orf54、LOC728763、LOC200772、LOC728208、SNED1、MTERFD2、PASK、PPP1R7、ANO7、HDLBP、SEPT2、FARP2、MIR3133、STK25、BOK-AS1、BOK、THAP4、ATG4B、DTYMK、ING5、D2HGDH、GAL3ST2、NEU4、PDCD1、CXXC11、FLJ38379、LOC100996616、LOC728323、DEFB125、DEFB126、DEFB127、DEFB128、DEFB129、DEFB132、C20orf96、ZCCHC3、LOC100507459、SOX12、NRSN2、TRIB3、RBCK1、TBC1D20、CSNK2A1、TCF15、SRXN1、SCRT2、SLC52A3、FAM110A、ANGPT4、RSPO4、PSMF1、TMEM74B、C20orf202、RAD21L1、SNPH、SDCBP2、FKBP1A-SDCBP2、SDCBP2-AS1、FKBP1A、NSFL1C、SIRPB2、SIRPD、SIRPB1、SIRPG、LOC100289473、SIRPA、PDYN、STK35、LOC388780、TGM3、TGM6、SNRPB、SNORD119、ZNF343、TMC2、NOP56、MIR1292、SNORD110、SNORA51、SNORD86、SNORD56、SNORD57、IDH3B、EBF4、CPXM1、C20orf141、TMEM239、PCED1A、VPS16、PTPRA、GNRH2、MRPS26、OXT、AVP、UBOX5-AS1、UBOX5、FASTKD5、PROSAPIP1、DDRGK1、ITPA、SLC4A11、C20orf194、ATRN、GFRA4、ADAM33、SIGLEC1、HSPA12B、C20orf27、SPEF1、CENPB、CDC25B、AP5S1、MAVS、PANK2、MIR103A2、MIR103B2、RNF24、SMOX、LOC728228、ADRA1D、PRNP、PRND、PRNT、RASSF2、SLC23A2、TMEM230、PCNA、PCNA-AS1、CDS2、PROKR2、LINC00658、LOC643406、LINC00654、GPCPD1、C20orf196、CHGB、TRMT6、MCM8、CRLS1、LRRN4、FERMT1、BMP2、HAO1、TMX4、PLCB1、RNU105B、PLCB4、 LAMP5、PAK7、SNAP25-AS1、ANKRD5、SNAP25、MKKS、SLX4IP、JAG1、LOC339593、LINC00687、BTBD3、LOC100996658、LOC100505515、SPTLC3、ISM1、ISM1-AS1、TASP1、ESF1、NDUFAF5、SEL1L2、MACROD2、FLRT3、MACROD2-AS1、KIF16B、SNRPB2、OTOR、PCSK2、BFSP1、DSTN、RRBP1、BANF2、SNX5、SNORD17、C20orf72、LOC100996673、OVOL2、PET117、CSRP2BP、ZNF133、DZANK1-AS1、DZANK1、POLR3F、MIR3192、RBBP9、SEC23B、LINC00493、DTD1、LINC00652、LOC100270804、C20orf78、SCP2D1、SLC24A3、LOC100130264、LOC100287166、RIN2、NAA20、CRNKL1、C20orf26、INSM1、RALGAPA2、PLK1S1、XRN2、NKX2-4、NKX2-2、PAX1、LOC100652902、LOC100270679、LOC100505651、LOC284788、LINC00261、FOXA2、SSTR4、THBD、CD93、LINC00656、LOC100505664、NXT1、LOC100505683、GZF1、NAPB、CSTL1、CST11、CST8、CST13P、CST9L、CST9、CST3、CST4、CST1、CST2、CST5、GGTLC1、FLJ33581、SYNDIG1、CST7、APMAP、ACSS1、VSX1、LOC284798、ENTPD6、PYGB、ABHD12、GINS1、NINL、NANP、ZNF337、FAM182B、LOC100289375、LOC100134868、FAM182A、NCOR1P1、LOC284801、MIR663A、FLJ45832、FRG1B、MLLT10P1、DEFB115、DEFB116、DEFB118、DEFB119、DEFB121、DEFB122、DEFB123、DEFB124、REM1、LINC00028、HM13、PSIMCT-1、HM13-AS1、ID1、MIR3193、COX4I2、BCL2L1、TPX2、MYLK2、FOXS1、DUSP15、TTLL9、PDRG1、XKR7、CCM2L、HCK、TM9S F4、TSPY26P、PLAGL2、POFUT1、MIR1825、KIF3B、ASXL1、C20orf112、LOC1499 50、C20orf203、COMMD7、DNMT3B、MAPRE1、EFCAB8、SUN5、BPIFB2、BPIFB6、BP IFB3、BPIFB4、BPIFA2、BPIFA4P、BPIFA3、BPIFA1、BPIFB1、CDK5RAP1、SNTA1、 CBFA2T2、NECAB3、C20orf144、ACTL10、E2F1、PXMP4、ZNF341、CHMP4B、RALY、 MIR4755、EIF2S2、ASIP、AHCY、ITCH、MIR644A、DYNLRB1、MAP1LC3A、PIGU、TP5 3INP2, NCOA6, HMGB3P1, GGT7, ACSS2, GSS, MYH7B, MIR499A, MIR499B, TRPC4AP, EDEM2, PROCR, MMP24, EIF6, FAM83C, UQCC, GDF5OS, GDF5, MIR1289-1, CEP 250、C20orf173、ERGIC3、FER1L4、SPAG4、CPNE1、RBM12、NFS1、ROMO1、RBM39 、PHF20、SCAND1、CNBD2、LINC00657、EPB41L1、AAR2、DLGAP4、MYL9、TGIF2、TG IF2-C20ORF24、C20orf24、SLA2、NDRG3、DSN1、SOGA1、C20orf118、SAMHD1、R BL1、C20orf132、RPN2、GHRH、MANBAL、SRC、BLCAP、NNAT、LINC00489、LOC1002 87792、CTNNBL1、VSTM2L、TTI1、RPRD1B、TGM2、KIAA1755、BPI、LBP、LOC3887 96、SNORA71B、SNORA71A、SNORA71C、SNORA71D、SNHG11、SNORA39、SNORA60、R ALGAPB、MIR548O2、ADIG、ARHGAP40、SLC32A1、ACTR5、PPP1R16B、FAM83D、DH X35、LOC339568、LOC100505663、MAFB、LOC100128988、TOP1、LOC100996518、PLCG1、ZHX3、LPIN3、EMILIN3、CHD6、PTPRT、SRSF6、L3MBTL1、SGK2、IFT52、MYBL2、GTSF1L、TOX2、JPH2、C20orf111、LOC100505783、GDAP1L1、FITM2、R3HDML、HNF4A、 MIR3646、TTPAL、SERINC3、PKIG、ADA、LOC79015、WISP2、KCNK15、RIMS4、YWH AB、PABPC1L、TOMM34、STK4-AS1、STK4、KCNS1、WFDC5、WFDC12、PI3、SEMG1、S EMG2、SLPI、MATN4、RBPJL、SDC4、SYS1、SYS1-DBNDD2、TP53TG5、DBNDD2、PIG T、LOC100130157、WFDC2、SPINT3、WFDC6、EPPIN-WFDC6、EPPIN、WFDC8、WFDC9 、WFDC10A、WFDC11、WFDC10B、WFDC13、MIR3617、SPINT4、WFDC3、DNTTIP1、UB E2C、TNNC2、SNX21、ACOT8、ZSWIM3、ZSWIM1、SPATA25、NEURL2、CTSA、PLTP、P CIF1, ZNF335, MMP9, LOC100128028, SLC12A5, NCOA5, CD40, CDH22, SLC35C2, ELMO2, ZNF663, MKRN7P, ZNF334, OCSTAMP, SLC13A3, TP53RK, SLC2A10, EYA2 、MIR3616、ZMYND8、LOC100131496、NCOA3、SULF2、LOC100505983、LOC10050 6053、LINC00494、LOC100506069、PREX1、ARFGEF2、CSE1L、STAU1、DDX27、ZN FX1、ZNFX1-AS1、SNORD12C、SNORD12B、SNORD12、KCNB1、PTGIS、LOC728671、 B4GALT5、SLC9A8、SPATA2、RNF114、SNAI1、LINC00651、UBE2V1、TMEM189-UBE 2V1、TMEM189、CEBPB、LOC100506115、LOC284751、PTPN1、MIR645、FAM65C、M IR1302-5、LOC100506175、PARD6B、BCAS4、ADNP、DPM1、MOCS3、KCNG1、NFATC2 、MIR3194、ATP9A、SALL4、ZFP64、TSHZ2、ZNF217、SUMO1P1、BCAS1、MIR4756、 CYP24A1、PFDN4、DOK5、CBLN4、MC3R、FAM210B、AURKA、CSTF1、CASS4、RTFDC1、GCNT7、LOC100130156、FAM209A、FAM209B、TFAP2C、BMP7、MIR4325、SPO11、RAE1、MTRNR2L3、LOC100291105、RBM38、CTCFL、PCK1、ZBP1、PMEPA1、MIR4532 、LOC100996602、C20orf85、ANKRD60、PPP4R1L、RAB22A、VAPB、APCDD1L、APCDD1L-AS1、MGC4294、STX16、STX16-NPEPL1、NPEPL1、LOC100652930、LOC1005 06348、MIR296、MIR298、GNAS-AS1、GNAS、TH1L、CTSZ、TUBB1、SLMO2-ATP5E、ATP5E、SLMO2、ZNF831、EDN3、PHACTR3、LOC100506384、SYCP2、FAM217B、PPP 1R3D、CDH26、C20orf197、LOC729296、LOC284757、MIR646、MIR4533、MIR548AG2、LOC100506470、CDH4、LOC100128310、MIR1257、TAF4、LSM14B、PSMA7、SS 18L1、GTPBP5、HRH3、FLJ44790、OSBPL2、ADRM1、LAMA5、MIR4758、RPS21、CABLES2、RBBP8NL、GATA5、C20orf166-AS1、C20orf166、MIR1-1、MIR133A2、LOC 100131174、LOC100505735、SLCO4A1、LOC100127888、NTSR1、LINC00659、MRGBP、OGFR、COL9A3、TCFL5、DPH3P1、DIDO1、GID8、SLC17A9、BHLHE23、LOC6393 0、LINC00029、LOC100144597、HAR1B、HAR1A、MIR124-3、YTHDF1、BIRC7、MIR3196、NKAIN4、FLJ16779、ARFGAP1、MIR4326、COL20A1、CHRNA4、KCNQ2、EEF1 A2、PPDPF、PTK6、SRMS、C20orf195、HELZ2、GMEB2、LOC100505771、STMN3、RTEL1、RTEL1-TNFRSF6B、TNFRSF6B、ARFRP1、ZGPAT、LIME1、SLC2A4RG、ZBTB46、C20orf181、ABHD16B、TPD52L2、DNAJC5、MIR941-1、MIR941-2、MIR941-3、MIR941-4、UCKL1、MIR1914、MIR647、UCKL1-AS1、ZNF512B、SAMD10、PRPF6、LINC00176、SOX18、TCEA2、RGS19、 OPRL1, C20orf201, NPBWR2, MYT1, PCMTD2, LINC00266-1, MIR3648, MIR3687 TEKT4P2, TPTE, BAGE2, ANKRD30BP2, MIR3156-3, POTED, MIR3118-5, LOC44 1956 C21orf15 ANKRD20A11P LIPI RBM11 ABCC13 HSPA13 SAMSN1 SAMS N1-AS1, LOC388813, NRIP1, USP25, LINC00478, MIR99A, MIRLET7C, MIR125B2 C21orf37, CXADR, BTG3, C21orf91-OT1, C21orf91, CHODL-AS1, CHODL, TMP RSS15, MIR548X, LOC100505973, LINC00320, NCAM2, LINC00317, LINC00308 D21S2088E LOC339622 LINC00158 MIR155HG MIR155 LINC00515 MRPL39 JAM2, ATP5J, GABPA, APP, LOC100996571, CYYR1, ADAMTS1, ADAMTS5, MIR475 9. LINC00113, LINC00314, LINC00161, N6AMT1, LTN1, RWDD2B, USP16, CCT8. C21orf7, LINC00189, BACH1, GREEK1, GREEK1-AS2, GREEK1-AS1, CLDN17, LINC00 307 CLDN8 KRTAP24-1 KRTAP25-1 KRTAP26-1 KRTAP27-1 KRTAP23-1 KR TAP13-2、MIR4327、KRTAP13-1、KRTAP13-3、KRTAP13-4、KRTAP15-1、KRTAP19 -1、KRTAP19-2、KRTAP19-3、KRTAP19-4、KRTAP19-5、KRTAP19-6、KRTAP19-7 、KRTAP22-2、KRTAP6-3、KRTAP6-2、KRTAP22-1、KRTAP6-1、KRTAP20-1、KRTAP 20-4, KRTAP20-2, KRTAP20-3, KRTAP21-3, KRTAP21-2, KRTAP21-1, KRTAP8- 1, KRTAP7-1, KRTAP11-1, KRTAP19-8, TIAM1, LOC150051, SOD1, SCAF4, HUNK.LINC00159、MIS18A、MRAP、URB1、SNORA80、C21orf119、EVA1C、TCP10L、C21o rf59、SYNJ1、GCFC1-AS1、GCFC1、C21orf49、C21orf62、OLIG2、OLIG1、C21or f54、IFNAR2、LOC100288432、IL10RB、IFNAR1、IFNGR2、TMEM50B、DNAJC28、G ART、SON、DONSON、CRYZL1、ITSN1、ATP5O、LINC00649、LINC00650、MRPS6、SLC 5A3、LINC00310、KCNE2、FAM165B、LOC388820、KCNE1、RCAN1、LOC100506369 、CLIC6、LINC00160、LOC100506385、RUNX1、RUNX1-IT1、LOC100506403、MIR8 02、LOC100996609、SETD4、LOC100133286、CBR1、CBR3-AS1、CBR3、DOPEY2、M ORC3、CHAF1B、CLDN14、SIM2、HLCS、DSCR6、PIGP、TTC3、DSCR9、DSCR3、DYRK1A 、KCNJ6、DSCR4、DSCR8、DSCR10、KCNJ15、ERG、LINC00114、ETS2、FLJ45139、P SMG1、BRWD1、BRWD1-IT2、BRWD1-AS1、HMGN1、WRB、LCA5L、SH3BGR、C21orf88、 B3GALT5、IGSF5、PCP4、DSCAM、MIR4760、DSCAM-AS1、DSCAM-IT1、LINC00323 、MIR3197、BACE2、PLAC4、FAM3B、MX2、MX1、TMPRSS2、LINC00111、LINC00479、 LINC00112、RIPK4、PRDM15、C2CD2、ZNF295、ZNF295-AS1、UMODL1、C21orf12 8、ABCG1、TFF3、TFF2、TFF1、TMPRSS3、UBASH3A、RSPH1、SLC37A1、PDE9A、WDR4 、NDUFV3、MIR5692B、PKNOX1、CBS、U2AF1、LOC100288336、CRYAA、LINC00322 、FLJ41733、SIK1、LINC00319、LINC00313、HSF2BP、RRP1B、PDXK、CSTB、RRP1、LOC284837、AGPAT3、TRAPPC10、PWP2、C21orf33、ICOSLG、DNMT3L、AIRE、PFKL、C21orf2、TRPM2、LRRC3-AS1、LRRC3、LRRC3DN、LOC100505727、TSPEAR、C21orf90、KRTAP10-1、 KRTAP10-2、KRTAP10-3、KRTAP10-4、KRTAP10-5、KRTAP10-6、KRTAP10-7、KRTAP10-8、KRTAP10-9、KRTAP10-10、KRTAP10-11、KRTAP12-4、KRTAP12-3、KRTAP AP12-2、KRTAP12-1、KRTAP10-12、UBE2G2、SUMO3、PTTG1IP、ITGB2、ITGB2-AS1、C21orf67、FAM207A、LINC00163、LINC00162、SSR4P1、ADARB1、POFUT2、LO C642852, LINC00315, LINC00316, LOC100505827, COL18A1, COL18A1-AS2, COL18A1-AS1, SLC19A1, LOC100129027, PCBP3, COL6A1, COL6A2, FTCD, SPATC1L, LSS, MCM3AP-AS1, MCM3AP, YBEY, C21orf58, PCNT, DIP2A, DIP2A-IT1, S100B, PRMT2, LOC400879, POTEH, OR11H1, CCT8L2, TPTEP1, ANKRD62P1-PARP4P3 、XKR3、HSFY1P1、GAB4、CECR7、IL17RA、CECR6、LOC100996342、CECR5、CECR5-AS1、CECR1、CECR3、CECR2、SLC25A18、ATP6V1E1、BCL2L13、BID、MIR3198-1、 LINC00528、MICAL3、MIR648、FLJ41941、PEX26、TUBA8、USP18、LOC642643、GGT3P、LOC100132900、LOC727983、DGCR6、PRODH、DGCR5、LOC100996369、LOC100996369 00287576、LOC100506454、DGCR9、DGCR10、DGCR2、DGCR11、DGCR14、TSSK2、GSC2、LOC100652736、SLC25A1、CLTCL1、HIRA、MRPL40、C22orf39、UFD1L、CDC4 5、CLDN5、LOC150185、SEPT5、SEPT5-GP1BB、GP1BB、TBX1、GNB1L、C22orf29、TXNRD2、COMT、MIR4761、ARVCF、C22orf25、MIR185、DGCR8、MIR3618、MIR1306、TRMT2A, RANBP1, ZDHHC8, LOC388849, LOC284865, LOC150197, RTN4R, MIR1286, DGCR6L, LOC729444, LOC100996401, TMEM191B, PI4KAP1, RIMBP3, ZNF74, SCARF2, KLHL22, MED15, POM121L4P, TMEM191A, PI4KA, SERPIND1, SNAP29, CRKL, AIFM3, LZTR1, THAP7, THAP7-AS1, TUBA3FP, P2RX6, SLC7A4, MIR649, P2R X6P、LOC400891、BCRP2、LOC284861、GGT2、LOC100132705、POM121L8P、LOC100996335、CA15P3、RIMBP3B、HIC2、LOC100996337、TMEM191C、PI4KAP2、RIMB P3C、UBE2L3、YDJC、CCDC116、SDF2L1、MIR301B、MIR130B、PPIL2、YPEL1、MAPK1、PPM1F、LOC100286925、TOP3B、PRAMEL、VPREB1、LOC96610、ZNF280B、ZNF2 80A、PRAME、LOC648691、POM121L1P、GGTLC2、MIR650、IGLL5、RTDR1、GNAZ、RAB36、BCR、FBXW4P1、CES5AP1、ZDHHC8P1、LOC388882、IGLL1、C22orf43、GUSB P11、RGL4、ZNF70、VPREB3、C22orf15、CHCHD10、MMP11、SMARCB1、DERL3、SLC2A11、LOC284889、MIF、LOC100652871、GSTT2B、DDTL、DDT、GSTT2、GSTTP1、LO C100996594、LOC391322、GSTT1、GSTTP2、CABIN1、LOC100652894、SUSD2、GGT5、POM121L9P、SPECC1L、ADORA2A、ADORA2A-AS1、UPB1、GUCD1、SNRPD3、GGT1 、FAM211B、BCRP3、POM121L10P、PIWIL3、TOP1P2、SGSM1、TMEM211、KIAA1671、LOC100128531、CRYBB3、CRYBB2、IGLL3P、LOC100652901、LRP5L、CRYBB2P1、LOC100507580、LOC100996404、ADRBK2、MYO18B、SEZ6L、ASPHD2、HPS4、SRRD 、TFIP11、LOC100507599、TPST2、MIR548J、CRYBB1、CRYBA4、MIAT、LOC10050 7657、MN1、PITPNB、TTC28-AS1、MIR3199-1、MIR3199-2、TTC28、CHEK2、HSCB 、CCDC117、XBP1、ZNRF3、ZNRF3-AS1、C22orf31、KREMEN1、EMID1、RHBDD3、EWS R1、GAS2L1、RASL10A、AP1B1、MIR3653、SNORD125、RFPL1-AS1、RFPL1、NEFH、 THOC5、NIPSNAP1、NF2、CABP7、ZMAT5、UQCR10、ASCC2、MTMR3、HORMAD2、LIF、 OSM、GATSL3、TBC1D10A、SF3A1、CCDC157、KIAA1656、RNF215、SEC14L2、MTFP 1、LOC646513、SEC14L3、SDC4P、SEC14L4、SEC14L6、GAL3ST1、PES1、TCN2、SLC 35E4、LOC100506075、DUSP18、OSBP2、MIR3200、MORC2-AS1、MORC2、TUG1、SM TN、SELM、INPP5J、PLA2G3、MIR3928、RNF185、LIMK2、PIK3IP1、PATZ1、MGC15 705、FLJ20464、DRG1、EIF4ENIF1、RNU6-28、SFI1、PISD、PRR14L、DEPDC5、C2 2orf24、YWHAH、SLC5A1、AP1B1P1、C22orf42、RFPL2、SLC5A4、RFPL3、RFPL3-A S1、LOC339666、C22orf28、BPIFC、FBXO7、SYN3、TIMP3、LARGE、MIR4764、LOC 100506195、ISX、HMGXB4、TOM1、MIR3909、HMOX1、MCM5、RASD2、MB、APOL6、APO L5、RBFOX2、LOC100131802、APOL3、APOL4、APOL2、APOL1、MYH9、TXN2、FOXRE D2、EIF3D、CACNG2、IFT27、PVALB、NCF4、CSF2RB、LOC100506241、TEX33、TST、MPST、KCTD17、TMPRSS6、IL2RB、C1QTNF6、SSTR3、RAC2、CYTH4、LOC100506271、ELFN2、MFNG、CARD10、CDC42EP1、LGALS2、GGA1、SH3BP1、PDXP、LGALS1、NOL 12、TRIOBP、H1F0、GCAT、GALR3、ANKRD54、MIR658、MIR659、EIF3L、MICALL1、C22orf23、POLR2F、SOX10、MIR4534、PICK1、SLC16A8、BAIAP2L2、PLA2G6、MAF F、TMEM184B、CSNK1E、LOC100996460、LOC400927、KCNJ4、KDELR3、DDX17、DMC1、FAM227A、CBY1、TOMM22、JOSD1、GTPBP1、SUN2、DNAL4、NPTXR、CBX6、APOBE C3A、APOBEC3B、APOBEC3C、APOBEC3D、APOBEC3F、APOBEC3G、APOBEC3H、CBX7、PDGFB、RPL3、SNORD83B、SNORD83A、RNU86、SNORD43、SYNGR1、TAB1、LOC1005 06472、MGAT3、SMCR7L、ATF4、RPS19BP1、CACNA1I、ENTHD1、GRAP2、FAM83F、LOC100130899、TNRC6B、ADSL、SGSM3、MKL1、MCHR1、SLC25A17、MIR4766、ST13、 XPNPEP3、DNAJB7、RBX1、MIR1281、EP300、L3MBTL2、LOC100506544、CHADL、RANGAP1、ZC3H7B、TEF、LOC100996598、TOB2、PHF5A、ACO2、POLR3H、CSDC2、PMM 1、DESI1、XRCC6、NHP2L1、LOC100506562、C22orf46、MEI1、CCDC134、SREBF2、MIR33A、SHISA8、MIR378I、TNFRSF13C、CENPM、LINC00634、SEPT3、WBP2NL、N AGA、FAM109B、C22orf32、NDUFA6、LOC100132273、CYP2D6、CYP2D7P1、TCF20、LOC388906、LOC100134361、NFAM1、SERHL、RRP7A、SERHL2、RRP7B、POLDIP3、RNU12、CYB5R3、ATP5L2、A4GALT、ARFGAP3、PACSIN2、LOC100506679、TTLL1、BIK、MCAT、TSPO、TTLL12、SCUBE1、MPPED1、EFCAB6-AS1、EFCAB6、SULT4A1、PNPLA5、PNPLA3、SAMM50、PARVB、PARVG、KIAA1644、LDOC1L、LINC00207、LINC00229、PRR5、PRR5-ARHGAP8、ARHGAP8、PHF21B、LOC100506695、LOC100506714、NUP50、 KIAA0930、MIR1249、UPK3A、FAM118A、SMC1B、RIBC2、FBLN1、LOC100506737、ATXN10、MIR4762、WNT7B、LOC730668、LOC100271722、C22orf26、LOC150381、 MIRLET7BHG、MIR3619、MIRLET7A3、MIR4763、MIRLET7B、PPARA、CDPF1、PKDREJ、TTC38、CN5H6.4、GTSE1、TRMU、CELSR1、GRAMD4、CERK、TBC1D22A、LOC1001 28818、FLJ46257、MIR3201、LOC100506877、FAM19A5、LOC284933、MIR4535、LOC100128946、MIR3667、C22orf34、BRD1、LOC90834、ZBED4、ALG12、CREL2 PIM3、IL17REL、TTLL8、MLC1、MOV10L1、PANX2、TRABD、SELO、TUBGCP6、HDAC10、MAPK12、MAPK11、PLXNB2、DENND6B、PPP6R2、SBF1、ADM2、MIOX、LMF2、NCAPH 2、SCO2、TYMP、ODF3B、KLHDC7B、SYCE3、CPT1B、CHKB-CPT1B、CHKB、LOC100144603、MAPK8IP2、ARSA、SHANK3、ACR、RPL23AP82、RABL2B、CHL1-AS2、CHL1、CN TN6、CNTN4、CNTN4-AS2、IL5RA、TRNT1、CRBN、LRRN1、SETMAR、SUMF1、ITPR1-AS1、ITPR1、EGOT、BHLHE40-AS1、BHLHE40、ARL8B、EDEM1、MIR4790、GRM7、LOC 100996542、LMCD1-AS1、LMCD1、LINC00312、SSUH2、CAV3、OXTR、RAD18、SRGAP3、THUMPD3、SETD5-AS1、LOC100996546、SETD5、LHFPL4、MTMR14、CPNE9、BRP F1、OGG1、CAMK1、TADA3、ARPC4、ARPC4-TTLL3、TTLL3、RPUSD3、CIDEC、JAGN1、IL17RE、IL17RC、CRELD1、PRRT3、PRRT3-AS1、EMC3、LOC442075、LOC401052CIDECP、FANCD2、FANCD2OS、BRK1、VHL、IRAK2、TATDN2、GHRLOS2、GHRL、GHRLOS、SEC13、ATP2B2、MIR378B、MIR885、LINC00606、SLC6A11、SLC6A1、SLC6A1- AS1、HRH1、ATG7、VGLL4、TAMM41、SYN2、TIMP4、PPARG、TSEN2、LOC100129480、MKRN2、RAF1、TMEM40、CAND2、RPL32、SNORA7A、IQSEC1、LOC100128644、NUP2 10、HDAC11、FBLN2、LOC100293612、LINC00620、WNT7A、FGD5P1、TPRXL、CHCHD4、TMEM43、XPC、LSM3、SLC6A6、GRIP2、CCDC174、C3orf20、FGD5、FGD5-AS1、N R2C2、MRPS25、ZFYVE20、COL6A4P1、CAPN7、SH3BP5-AS1、SH3BP5、METTL6、EAF1、COLQ、MIR4270、HACL1、BTD、ANKRD28、MIR3134、MIR563、GALNTL2、DPH3、O XNAD1、RFTN1、LINC00690、DAZL、PLCL2、MIR3714、TBC1D5、LOC100505786、LOC339862、SATB1、KCNH8、MIR4791、EFHB、RAB5A、PP2D1、KAT2B、MIR3135A、SG OL1、SGOL1-AS1、VENTXP7、ZNF385D、LOC100505836、UBE2E2-AS1、UBE2E2、UBE2E1、NKIRAS1、RPL15、NR1D2、LINC00691、THRB、THRB-AS1、MIR4792、LOC10 0505947, RARB, TOP2B, MIR4442, NGLY1, OXSM, LINC00692, LRRC3B, NEK10, SLC4A7, EOMES, LOC100996624, CMC1, AZI2, ZCWPW2, LINC00693, LOC100652807, RBMS3, TGFBR2, GADL1, STT3B, OSBPL10, OSBPL10-AS1, ZNF860, GPD1L, CMTM8, CMTM7, CMTM6, DYNC1LI1, CNOT10, YPLR6490, TRIM71, CCR4, GLB1, TMPPE,CRTAP、SUSD5、FBXL2、UBP1、CLASP2、PDCD6IP、ARPP21、MIR128-2、STAC、DCLK3、TRANK1、EPM2AIP1、MLH1、LRRFIP2、GOLGA4、C3orf35、ITGA9、CTDSPL、MIR26A1、 VILL、PLCD1、DLEC1、ACAA1、MYD88、OXSR1、SLC22A13、SLC22A14、XYLB、ACVR2B-AS1、ACVR2B、EXOG、SCN5A、SCN10A、SCN11A、WDR48、GORASP1、TTC21A、CSRNP1、XIRP1、LOC729454、CX3CR1、CCR8、SLC25A38、RPSA、SNORA6、SNORA62、MOBP、MYRIP、EIF1B-AS1、EIF1B、ENTPD3、ENTPD3-AS1、RPL14、ZNF619、ZNF620、ZNF621、CTNNB1、ULK4、TRAK1、CCK、LYZL4、VIPR1、SEC22C、SS18L2、NKTR、ZBTB47、KBTBD5、HHATL、CCDC13、CCDC13-AS1、HIGD1A、CCBP2、CYP8B1、ZNF662、KRBOX1-AS1、KRBOX1、FAM198A、GTDC2、SNRK、SNRK-AS1、ANO10、ABHD5、MIR138-1、TOPAZ1、TCAIM、LOC100506301、LOC100506319、ZNF445、ZNF852、ZNF167、ZNF660、ZNF197、ZNF35、ZNF502、ZNF501、KIAA1143、KIF15、MIR564、TMEM42、TGM4、ZDHHC3、EXOSC7、CLEC3B、CDCP1、TMEM158、LARS2、LARS2-AS1、LIMD1、LIMD1-AS1、SACM1L、SLC6A20、LZTFL1、CCR9、FYCO1、CXCR6、XCR1、CCR1、CCR3、CCR2、CCR5、CCRL2、LTF、RTP3、LRRC2、TDGF1、LOC100132146、ALS2CL、TMIE、PRSS50、PRSS46、PRSS45、PRSS42、MYL3、LOC100996656、PTH1R、CCDC12、NBEAL2、NRADDP、SETD2、FLJ39534、KIF9、KLHL18、PTPN23、SCAP、ELP6、CSPG5、SMARCC1、LOC100996661、DHX30、MIR1226、MAP4、CDC25A、MIR4443、CAMP、ZNF589、NME6、SPINK8、MIR2115、FBXW12、PLXNB1、CCDC51、TMA7、ATRIP、TREX1、SHISA5、PFKFB4、UCN2、COL7A1、MIR711、UQCRC1、TMEM89、SLC26A6、C ELSR3、MIR4793、NCKIPSD、IP6K2、PRKAR2A、PRKAR2A-AS1、SLC25A20、ARIH2 OS, ARIH2, LOC100506651, P4HTM, WDR6, DALRD3, MIR425, NDUFAF3, MIR191, IMPDH2, QRICH1, QARS, USP19, LAMB2, LAMB2P1, CCDC71, KLHDC8B, LOC646498 、CCDC36、STGC3、C3orf62、MIR4271、USP4、GPX1、RHOA、TCTA、AMT、NICN1、DA G1、BSN-AS2、BSN、APEH、MST1、RNF123、AMIGO3、GMPPB、IP6K1、CDHR4、FAM212 A, UBA7, MIR5193, TRIP, CAMKV, MST1R, MON1A, RBM6, RBM5, LUST, LOC100129060, SEMA3F, MIR566, GNAT1, SLC38A3, GNAI2, SEMA3B, C3orf45, IFRD2, HYA L3, NAT6, HYAL1, HYAL2, TUSC2, RASSF1, ZMYND10, NPRL2, CYB561D2, TMEM115, CACNA2D2, C3orf18, HEMK1, CISH, MAPKAPK3, MIR4787, DOCK3, MANF, RBM1 5B、VPRBP、RAD54L2、TEX264、GRM2、IQCF6、IQCF4、IQCF3、IQCF2、IQCF5、IQC F1、RRP9、PARP3、GPR62、PCBP4、ABHD14B、ABHD14A-ACY1、ABHD14A、ACY1、RPL 29、DUSP7、C3orf74、POC1A、ALAS1、TLR9、TWF2、PPM1M、WDR82、MIRLET7G、GL YCTK、MIR135A1、DNAH1、BAP1、PHF7、SEMA3G、TNNC1、NISCH、STAB1、NT5DC2、S MIM4、PBRM1、GNL3、SNORD19、SNORD19B、SNORD69、GLT8D1、SPCS1、NEK4、ITI H1、ITIH3、ITIH4、TMEM110-MUSTN1、MUSTN1、TMEM110、SFMBT1、RFT1、PRKCD、TKT, DCP1A, CACNA1D, CHDH, IL17RB, ACTR8, SELK, CACNA2D3, ESRG, CACNA2D3-AS1, LRTM1, WNT5A, ERC2, ERC2-IT1, MIR3938, CCDC66, FAM208A, ARHGEF3 ARHGEF3-AS1、SPATA12、IL17RD、HESX1、APPL1、ASB14、DNAH12、PDE12、ARF4 、DENND6A、SLMAP、FLNB、DNASE1L3、ABHD6、RPP14、PXK、PDHB、KCTD6、ACOX2、 FAM107A、FAM3D、C3orf67、FHIT、NPCDR1、PTPRG、LOC100506994、C3orf14、F EZF2、CADPS、LOC285401、SYNPR、SYNPR-AS1、SNTN、C3orf49、THOC7、ATXN7、P SMD6-AS2、PSMD6、PRICKLE2-AS1、LOC100287879、PRICKLE2、PRICKLE2-AS2、PRICKLE2-AS3、ADAMTS9、ADAMTS9-AS2、MAGI1、MAGI1-IT1、MAGI1-AS1、LOC 100508226、SLC25A26、LRIG1、LOC100996321、KBTBD8、MIR4272、SUCLG2、FA M19A1、FAM19A4、EOGT、TMF1、MIR3136、UBA3、ARL6IP5、LMOD3、FRMD4B、MITF、 FOXP1、MIR1284、FOXP1-IT1、EIF4E3、GPR27、PROK2、LOC201617、RYBP、LOC1 00506865、SHQ1、GXYLT2、PPP4R2、EBLN2、PDZRN3、CNTN3、FAM86DP、MIR1324、 FRG2C、LOC100996350、LOC401074、ZNF717、MIR4273、ROBO2、ROBO1、MIR392 3、LOC728290、GBE1、LOC440970、CADM2、MIR5688、CADM2-AS2、VGLL3、MIR479 5、CHMP2B、POU1F1、HTR1F、CGGBP1、ZNF654、C3orf38、LOC100506944、EPHA3 、PROS1、ARL13B、STX19、DHFRL1、NSUN3、LOC255025、EPHA6、ARL6、CRYBG3、MI NA、GABRR3、OR5AC2、OR5H1、OR5H14、OR5H15、OR5H6、OR5H2、OR5K4、OR5K3、O R5K1、OR5K2、CLDND1、GPR15、CPOX、ST3GAL6-AS1、ST3GAL6、DCBLD2、RNU6-8、LOC100506377、COL8A1、CMSS1、FILIP1L、MIR3921、TMEM30C、TBC1D23、NIT2 、TOMM70A、LNP1、TMEM45A、GPR128、TFG、ABI3BP、IMPG2、SENP7、LOC1002878 52、FAM172BP、TRMT10C、PCNP、ZBTB11、LOC100009676、RPL24、PDCL3P4、CEP 97、NXPE3、NFKBIZ、LOC152225、ZPLD1、MIR548AB、ALCAM、CBLB、LOC10030264 0、LOC344595、CCDC54、BBX、LINC00635、LINC00636、CD47、IFT57、HHLA2、MY H15、KIAA1524、DZIP3、RETNLB、TRAT1、GUCA1C、MORC1、FLJ22763、LINC00488 、DPPA2、DPPA4、FLJ25363、MIR4445、LOC151760、PVRL3-AS1、PVRL3、CD96、Z BED2、PLCXD2、PHLDB2、ABHD10、TAGLN3、TMPRSS7、C3orf52、MIR567、GCSAM、S LC9C1、CD200、BTLA、ATG3、SLC35A5、CCDC80、CD200R1L、CD200R1、GTPBP8、C 3orf17、BOC、WDR52、WDR52-AS1、SPICE1、SIDT1、MIR4446、KIAA2018、NAA50 ATP6V1A, GRAMD1C, ZDHHC23, KIAA1407, QTRTD1, DRD3, ZNF80, TIGIT, MIR568, ZBTB20, ZBTB20-AS1, MIR4796, GAP43, LSAMP, LSAMP-AS3, MIR4447, LSAM P-AS4、IGSF11、IGSF11-AS1、C3orf30、UPK1B、B4GALT4、ARHGAP31、TMEM39A 、POGLUT1、TIMMDC1、CD80、ADPRH、PLA1A、POPDC2、COX17、MAATS1、NR1I2、GSK 3B、LOC100996310、GPR156、LRRC58、FSTL1、MIR198、NDUFB4、HGD、RABL3、GT F2E1、STXBP5L、MIR5682、POLQ、ARGFX、FBXO40、HCLS1、GOLGB1、IQCB1、EAF2、SLC15A2、ILDR1、CD86、CASR、CSTA、CCDC58、FAM162A、WDR5B、KPNA1、PARP9、DTX3L、PARP15、PARP14、HSPBAP1、DIRC2、LOC100129550、SEMA5B、PDIA5、 SEC22A、ADCY5、PTPLB、MYLK-AS1、MYLK、CCDC14、ROPN1、KALRN、MIR5002、UM PS、MIR544B、ITGB5、MUC13、HEG1、SLC12A8、MIR5092、ZNF148、SNX4、OSBPL11 、MIR548I1、FAM86JP、ALG1L、ROPN1B、SLC41A3、ALDH1L1、ALDH1L1-AS1、ALD H1L1-AS2、KLF15、LOC100506907、CCDC37、ZXDC、UROC1、CHST13、C3orf22、TX NRD3NB、TXNRD3、NUP210P1、CHCHD6、LOC100132481、PLXNA1、C3orf56、TPRA 1、MCM2、PODXL2、ABTB1、MGLL、KBTBD12、SEC61A1、RUVBL1、EEFSEC、DNAJB8、D NAJB8-AS1、GATA2、LOC90246、C3orf27、RPN1、RAB7A、LOC653712、ACAD9、KI AA1257、CCDC48、GP9、RAB43、ISY1-RAB43、ISY1、CNBP、COPG1、C3orf37、H1FX 、H1FX-AS1、RPL32P3、SNORA7B、EFCAB12、MBD4、IFT122、RHO、H1FOO、PLXND1 、TMCC1、LOC100507032、TRH、ARVP6125、ALG1L2、FAM86HP、COL6A4P2、COL6A5 、COL6A6、PIK3R4、ATP2C1、ASTE1、NEK11、LOC339874、NUDT16P1、NUDT16、MR PL3、SNORA58、LOC100507134、CPNE4、MIR5704、ACPP、LOC100996371、DNAJC1 3、NPHP3-ACAD11、ACAD11、CCRL1、UBA5、NPHP3、NPHP3-AS1、TMEM108、BFSP2 、CDV3、TOPBP1、TF、SRPRB、RAB6B、C3orf36、SLCO2A1、LOC100507210、RYK、AM OTL2、LOC100507224、MIR4788、ANAPC13、CEP63、KY、EPHB1、PPP2R3A、MSL2、P CCB、STAG1、SLC35G2、NCK1、IL20RB、SOX14、LOC100507274、CLDN18、DZIP1L、A4GNT, DBR1, ARMC8, NME9, MRAS, ESYT3, CEP70, FAIM, PIK3CB, FOXL2, C3orf72, PRR23A, PRR23B, PRR23C, BPESC1, PISRT1, MRPS22, COPB2, LOC100507291 、RBP2、RBP1、NMNAT3、CLSTN2、TRIM42、SLC25A36、SPSB4、ACPL2、ZBTB38、RA SA2、LOC646730、RNF7、GRK7、ATP1B3、TFDP2、GK5、XRN1、ATR、PLS1、TRPC1、PC OLCE2、LOC100507389、PAQR9、LOC100289361、U2SURP、CHST2、SLC9A9、SLC9 A9-AS1、C3orf58、PLOD2、PLSCR4、LOC440981、PLSCR2、PLSCR1、PLSCR5、ZIC4 、ZIC1、LOC100507447、LOC100507461、AGTR1、CPB1、CPA3、GYG1、HLTF、HLTF -AS1、HPS3、CP、TM4SF18、TM4SF1、TM4SF4、WWTR1、WWTR1-AS1、COMMD2、ANKUB 1、RNF13、PFN2、LOC646903、TMEM183B、TSC22D2、SERP1、EIF2A、SELT、FAM19 4A、SIAH2、CLRN1、CLRN1-AS1、MED12L、GPR171、P2RY14、GPR87、P2RY13、P2RY 12、IGSF10、MIR5186、AADACL2、LOC201651、AADAC、SUCNR1、LOC401093、MBN L1、TMEM14E、P2RY1、RAP2B、C3orf79、ARHGEF26-AS1、ARHGEF26、DHX36、GPR1 49、MME、LOC100507537、PLCH1、LOC100507556、C3orf33、SLC33A1、GMPS、KC NAB1、KCNAB1-AS2、KCNAB1-AS1、SSR3、TIPARP-AS1、TIPARP、LOC730091、PA2 G4P4、LEKR1、LOC339894、LOC100498859、CCNL1、VEPH1、PTX3、C3orf55、SHO X2, RSRC1, LOC100996447, MLF1, GFM1, LXN, RARRES1, LOC100287290, MFSD1,IQCJ-SCHIP1、IQCJ、SCHIP1、MIR3919、IL12A、C3orf80、IFT80、SMC4、MIR15B、MIR16-2、TRIM59、KPNA4、SCARNA7、ARL14、PPM1L、B3GALNT1、NMD3、SPTSSB、OTOL1、LOC647107、 MIR1263、SI、SLITRK3、BCHE、ZBBX、SERPINI2、WDR49、PDCD10、SERPINI1、LO C100996456、LOC646168、GOLIM4、EGFEM1P、MIR551B、LOC100507661、MECOM 、TERC、ACTRT3、MYNN、LRRC34、LRRIQ4、LRRC31、SAMD7、LOC100128164、SEC6 2、GPR160、PHC3、PRKCI、SKIL、CLDN11、SLC7A14、RPL22L1、EIF5A2、SLC2A2、T NIK, MIR569, PLD1, TMEM212, FNDC3B, GHSR, TNFSF10, NCEH1, ECT2, SPATA16, NLGN1, NALADL2, NALADL2-AS3, MIR4789, LOC100505547, TBL1XR1, LINC0 0578、KCNMB2-IT1、KCNMB2、ZMAT3、PIK3CA、KCNMB3、ZNF639、MFN1、GNB4、AC TL6A、MRPL47、NDUFB5、USP13、PEX5L、LOC100505609、TTC14、CCDC39、FXR1、D NAJC19、SOX2-OT、SOX2、LOC100996490、FLJ46066、ATP11B、DCUN1D1、MCCC1 、LAMP3、MCF2L2、B3GNT5、LOC100505687、KLHL6、KLHL24、YEATS2、MAP6D1、PA RL、MIR4448、ABCC5、ABCC5-AS1、HTR3D、HTR3C、HTR3E、EIF2B5、DVL3、AP2M1 、ABCF3、VWA5B2、MIR1224、ALG3、ECE2、CAMK2N2、PSMD2、EIF4G1、SNORD66、FA M131A、CLCN2、POLR2H、THPO、CHRD、EPHB3、MAGEF1、LOC100505710、VPS8、LO C100505729、C3orf70、EHHADH-AS1、EHHADH、MAP3K13、TMEM41A、LIPH、SENP2 、IGF2BP2、C3orf65、MIR548AQ、TRA2B、LOC344887、ETV5、DGKG、LOC253573、 CRYGS、TBCCD1、DNAJB11、AHSG、FETUB、HRG、KNG1、EIF4A2、SNORD2、SNORA81、SNORA63、SNORA4、RFC4、ADIPOQ、ADIPOQ-AS1、ST6GAL1、LOC100508227、RPL 39L、RTP1、MASP1、RTP4、SST、RTP2、LOC100131635、BCL6、LPP-AS2、LPP、FLJ 42393、MIR28、TPRG1、TPRG1-AS2、TP63、MIR944、LEPREL1、CLDN1、CLDN16、T MEM207、IL1RAP、GMNC、SNAR-I、OSTN、UTS2D、CCDC50、PYDC2、FGF12、MB21D2 、HRASLS、MGC2889、ATP13A5、ATP13A4、OPA1、OPA1-AS1、LOC647323、LOC100 128023、LOC100505902、HES1、LOC100505920、LOC100131551、CPN2、LRRC15 、GP5、ATP13A3、FLJ34208、LOC100507033、TMEM44-AS1、TMEM44、LSG1、FAM4 3A、LOC100507391、XXYLT1、MIR3137、ACAP2、PPP1R2、APOD、SDHAP2、MIR570、 LOC440993、MUC20、MUC4、TNK2、LOC100128262、SDHAP1、TFRC、LOC401109、Z DHHC19、SLC51A、PCYT1A、TCTEX1D2、TM4SF19-TCTEX1D2、TM4SF19、UBXN7、R NF168、C3orf43、WDR53、FBXO45、LRRC33、CEP19、PIGX、PAK2、RNU6-42、SENP 5、NCBP2、LOC152217、PIGZ、MFI2、MFI2-AS1、DLG1、MIR4797、DLG1-AS1、LOC1 00129516、BDH1、LOC220729、KIAA0226、MIR922、FYTTD1、LRCH3、IQCG、RPL3 5A、LMLN、ANKRD18DP、FAM157A、ZNF595、ZNF718、ZNF876P、ZNF732、LOC1009 96363、ZNF141、MIR571、ABCA11P、ZNF721、PIGG、PDE6B、ATP5I、MYL5、MFSD7 、PCGF3、LOC100129917、CPLX1、GAK、TMEM175、DGKQ、SLC26A1、IDUA、FGFRL1、RNF212, TMED11P, FLJ35816, SPON2, LOC100130872, LOC285463, CTBP1, CTBP1-AS1, MAEA, UVSSA, CRIPAK, LOC100507054, FAM53A, SLBP, TMEM129, TACC3, FGFR3, LETM1, WHSC1, SCARNA22, WHSC2, MIR943、C4orf48、NAT8L、POLN、HAUS3、MXD4、MIR4800、ZFYVE28、LOC402160、RNF4、FAM193A、TNIP2、SH3BP2、ADD1、MFSD10、NOP14-AS1、NOP14、GRK4、HTT-AS1、HTT、MSANTD1、RGS12、HGFAC、DOK7、LRPAP1、FLJ35424、LOC100133461、LOC100507150、ADRA2C、FAM86EP、OTOP1、TMEM128、LYAR、ZBTB49、NSG1、STX18、LOC100507266、MSX1、CYTL1、STK32B、C4orf6、EVC2、EVC、CRMP1、MIR378D1、C4orf50、JAKMIP1、LOC285484、WFS1、PPP2R2C、MAN2B2、MRFAP1、LOC100507376、LOC93622、S100P、MRFAP1L1、BLOC1S4、KIAA0232、TBC1D14、LOC100129931、CCDC96、TADA2B、GRPEL1、FLJ36777、SORCS2、MIR4798、PSAPL1、MIR4274、AFAP1-AS1、AFAP1、ABLIM2、MIR95、SH3TC1、HTRA3、ACOX3、TRMT44、GPR78、CPZ、HMX1、LOC650293、USP17L10、USP17L11、USP17L12、USP17L13、USP17L15、USP17L17、USP17L18、USP17L19、USP17L20、USP17L21、USP17L22、USP17L24、USP17L25、USP17L26、USP17L5、USP17L27、USP17L28、USP17L29、USP17L9P、USP17L30、USP17L6P、DEFB131、MIR548I2、DRD5、SLC2A9、WDR1、MIR3138、ZNF518B、CLNK、MIR572、HS3ST1、HSP90AB2P、RAB28、LOC285547、NKX3-2、LOC285548、BOD1L1、MIR5091、LOC152742、LOC441009、CPEB2、C1QTNF7、CC2D2A、FBXL5、LOC100996623、FAM200B、BST1、CD38、FGFBP1、FGFBP2、PROM1、TAPT1、TAPT1-AS1、LDB2、QDPR、CLRN2、LAP3、MED28、FAM184B、DCAF16、NCAPG、LCORL、SLIT2、SLIT2-IT1、MIR218-1、PACRGL、KCNIP4、KCNIP4-IT1、LOC100505912、GPR125、GBA3、PPARGC1A、LOC729175、MIR573、DHX15、SOD3、CCDC149、LGI2、SEPSECS、LOC285540、PI4K2B、ZCCHC4、ANAPC4、SLC34A2、LOC100996632、SEL1L3、C4orf52、RBPJ、CCKAR、TBC1D19、LOC100506048、STIM2、MIR4275、PCDH7、ARAP2、DTHD1、MIR1255B1、MIR4801、KIAA1239、C4orf19、RELL1、PGM2、TBC1D1、PTTG2、FLJ13197、KLF3、TLR10、TLR1、TLR6、FAM114A1、MIR574、TMEM156、KLHL5、WDR19、RFC1、KLB、MIR5591、RPL9、LIAS、LOC401127、UGDH、UGDH-AS1、C4orf34、UBE2K、PDS5A、LOC344967、N4BP2、RHOH、CHRNA9、RBM47、MIR4802、NSUN7、APBB2、UCHL1、LIMCH1、PHOX2B、TMEM33、DCAF4L1、SLC30A9、BEND4、SHISA3、ATP8A1、GRXCR1、LOC100506827、KCTD8、YIPF7、GUF1、GNPDA2、GABRG1、GABRA2、COX7B2、GABRA4、GABRB1、COMMD8、ATP10D、CORIN、NFXL1、CNGA1、NIPAL1、TXK、TEC、SLAIN2、SLC10A4、ZAR1、FRYL、OCIAD1、OCIAD2、CWH43、DCUN1D4、LRRC66、SGCB、SPATA18、USP46、USP46-AS1、DANCR、MIR4449、SNORA26、ERVMER34-1、LOC152578、RASL11B、SCFD2、FIP1L1、LNX1、LNX1-AS1、LNX1-AS2、RPL21P44、CHIC2、GSX2、PDGFRA、KIT、KDR、SRD5A3、SRD5A3-AS1、TMEM165、CLOCK、PDCL2、NMU、LOC644145、EXOC1、CEP135、KIAA1211、AASDH、PPAT、PAICS、SRP72、ARL9、THEGL、HOPX、SPINK2、REST、NOA1、POLR2B、IGFBP7、LOC255130、LOC100507160、 MIR548AG1、LPHN3、TECRL、LOC401134、EPHA5、LOC100144602、MIR1269A、CE NPC1、STAP1、UBA6、LOC550112、GNRHR、TMPRSS11D、TMPRSS11A、TMPRSS11GP、 TMPRSS11F、LOC550113、SYT14L、FTLP10、TMPRSS11BNL、TMPRSS11B、YTHDC1 、TMPRSS11E、UGT2B17、UGT2B15、UGT2B10、UGT2A3、UGT2B7、UGT2B11、UGT2B2 8、UGT2B4、UGT2A1、UGT2A2、SULT1B1、SULT1E1、CSN1S1、CSN2、STATH、HTN3、 HTN1、CSN1S2AP、CSN1S2BP、C4orf40、ODAM、FDCSP、CSN3、CABS1、SMR3A、SMR3 B、PROL1、MUC7、AMTN、AMBN、ENAM、IGJ、UTP3、RUFY3、GRSF1、MOB1B、DCK、SLC 4A4、GC、NPFFR2、ADAMTS3、COX18、ANKRD17、ALB、AFP、AFM、LOC728040、RASSF 6、IL8、CXCL6、PF4V1、CXCL1、PF4、PPBP、CXCL5、CXCL3、PPBPP2、CXCL2、MTHF D2L、EPGN、EREG、AREG、AREGB、BTC、PARM1、LOC100507388、LOC100505946、LO C100506253、LOC441025、RCHY1、THAP6、C4orf26、CDKL2、G3BP2、USO1、PPEF 2、NAAA、SDAD1、CXCL9、ART3、CXCL10、CXCL11、NUP54、SCARB2、FAM47E、FAM47 E-STBD1、STBD1、CCDC158、SHROOM3、MIR4450、MIR548AH、LOC100996628、SO WAHB、SEPT11、LOC100131826、CCNI、CCNG2、CXCL13、CNOT6L、MRPL1、FRAS1、A NXA3、LOC100505702、BMP2K、MIR5096、PAQR3、LOC100505875、NAA11、GK2、L OC100506035、GDEP、ANTXR2、PRDM8、FGF5、C4orf22、BMP3、PRKG2、RASGEF1B、HNRNPD, HNRPDL, ENOPH1, TMEM150C, LINC00575, SCD5, MIR575, SEC31A, THAP9-AS1, THAP9, LIN54, COPS4, PLAC8, COQ2, HPSE, HELQ, MRPS18C, FAM175A, A GPAT9, NKX6-1, CDS1, WDFY3, WDFY3-AS2, ARHGAP24, MIR4451, MAPK10, MIR4452, PTPN13, SLC10A6, C4orf36, LOC100506746, AFF1, KLHL8, MIR5705, HSD1 7B13, HSD17B11, NUDT9, SPARCL1, DSPP, DMP1, IBSP, MEPE, HSP90AB3P, SPP1, PKD2, ABCG2, PPM1K, HERC6, HERC5, PYURF, PIGY, HERC3, RNU6-33, NAP1L5, FAM13A-AS1, FAM13A, TIGD2, GPRIN3, SNCA, LOC644248, MMRN1, FAM190A, GRID2, ATOH1, SMARCAD1, HPGDS, PDLIM5, LOC100507012, BMPR1B, UNC5C, PDHA2, RNU6-34, STPG2, RAP1GDS1, TSPAN5, EIF4E, METAP1, MIR3684, ADH5, LOC100507053, ADH4, PCNAP1, ADH6, ADH1A, ADH1B, ADH1C, ADH7, C4orf17, TRMT10A, MTTP, LOC285556, DAPP1, LAMTOR3, DNAJB14, H2AFZ, LOC256880, DDIT4L, EMCN, EMCN-IT3, PPP3CA, MIR1255A, FLJ20021, BANK1, SLC39A8, NFKB1, MANBA, UBE2D3, CISD2, SLC9B1, SLC9B2, BDH2, CENPE, TACR3, CXXC4, TET2, PPA2, ARHGEF38, ARHGEF38-IT1, INTS12, GSTCD, NPNT, TBCK, AIMP1, GIMD1, DKK2, PAP SS1、SGMS2、CYP2U1、HADH、LEF1、LEF1-AS1、RPL34-AS1、RPL34、OSTC、AGXT2L1、COL25A1、SEC24B-AS1、SEC24B、MIR576、CCDC109B、CASP6、PLA2G12A、CFI、GAR1, RRH, LRIT3, EGF, RNU6-35, ELOVL6, ENPEP, PITX2, MIR297, C4orf32, AP1AR, TIFA, ALPK1, NEUROG2, C4orf21, LARP7, MIR367, MIR302D, MIR302A MIR302C, MIR302B, ANK2, MIR1243, CAMK2D, LOC100507209, ARSJ, UGT8, MIR 577、NDST4、MIR1973、TRAM1L1、NDST3、SNHG8、SNORA24、PRSS12、CEP170P1、 METTL14、SEC24D、SYNPO2、MYOZ2、USP53、C4orf3、FABP2、FLJ14186、LOC100 507306、LOC645513、PDE5A、LOC100996694、MAD2L1、PRDM5、NDNF、TNIP3、QRF PR, ANXA5, TMEM155, PP12613, EXOSC9, CCNA2, BBS7, TRPC3, KIAA1109, ADAD 1、IL2、IL21、CETN4P、BBS12、FGF2、NUDT6、SPATA5、SPRY1、LOC285419、ANKRD 50、FAT4、MIR2054、INTU、SLC25A31、HSPA4L、PLK4、MFSD8、C4orf29、LARP1B 、PGRMC2、LOC100507487、PHF17、SCLT1、C4orf33、PCDH10、PABPC4L、LINC006 13、PCDH18、LINC00616、SLC7A11-AS1、SLC7A11、LINC00499、CCRN4L、ELF2、 MGARP, NDUFC1, NAA15, RAB33B, SETD7, MGST2, MAML3, SCOC, LOC100129858, C LGN、ELMOD2、UCP1、TBC1D9、RNF150、ZNF330、LOC100507639、IL15、INPP4B、 USP38、GAB1、MIR3139、SMARCA5、SMARCA5-AS1、GUSBP5、FREM3、GYPE、GYPB、G YPA、HHIP-AS1、HHIP、LOC100505491、ANAPC10、ABCE1、OTUD4、SMAD1、MMAA、 C4orf51, ZNF827, LOC100505545, LSM6, LOC345051, SLC10A7, POU4F2, TTC29 、LOC100505596、MIR548G、EDNRA、TMEM184C、PRMT10、ARHGAP10、MIR4799、N R3C2、LOC285423、DCLK2、LRBA、MAB21L2、RPS3A、SNORD73A、SH3D19、PRSS48、FAM160A1、PET112、LOC100505685、LOC100996286、FBXW7、MIR3140、DKFZP434I0714、MIR4453、TMEM154、TIGD4、ARFIP1、FHDC1、TRIM2、ANXA2P1、MND1、KIAA0922、TLR2、RNF175、SFRP2、DCHS2、PLRG1、FGB、FGA、FGG、LRAT、RBM46、NPY2R、MAP9、GUCY1A3、GUCY1B3、ASIC5、TDO2、CTSO、LOC100505784、PDGFC、GLRB、GRIA2、LOC340017、FAM198B、TMEM144、RXFP1、C4orf46、ETFDH、PPID、FNIP2、C4orf45、MIR3688-1、MIR3688-2、RAPGEF2、FSTL5、MIR4454、NAF1、NPY1R、NPY5R、TKTL2、TMA16、MARCH1、ANP32C、LOC100505989、LOC100506013、TRIM61、FAM218A、TRIM60、TMEM192、KLHL2、GK3P、MSMO1、CPE、MIR578、TLL1、SPOCK3、ANXA10、DDX60、DDX60L、PALLD、CBR4、SH3RF1、NEK1、CLCN3、C4orf27、LOC100506085、MFAP3L、AADAT、HSP90AA6P、LOC100506107、LOC100506122、GALNTL6、GALNT7、MIR548T、HMGB2、SAP30、SCRG1、HAND2、NBLA00301、LOC100506154、FBXO8、CEP44、MIR4276、HPGD、GLRA3、ADAM29、GPM6A、WDR17、SPATA4、ASB5、SPCS3、VEGFC、NEIL3、AGA、LOC285501、LINC00290、MGC45800、MIR1305、TENM3、DCTD、FAM92A1P2、WWC2-AS2、WWC2、CLDN22、CLDN24、CDKN2AIP、LOC389247、ING2、RWDD4、TRAPPC11、STOX2、ENPP6、LOC391722、LOC728175、IRF2、LOC100996305、CASP3、CCDC111、MLF1IP、ACSL1、SLED1、LOC731424、MIR3945, LOC100506229, MIR4455, HELT, SLC25A4, KIAA1430, SNX25, LRP2BP, ANKRD37, UFSP2, C4orf47, CCDC110, PDLIM3, SORBS2, TLR3, FAM149A, FLJ38576, CYP4V2, KLKB1, F11, LOC285441, MTNR1A、FAT1、LOC339975、LOC100506272、ZFP42、TRIML2、TRIML1、LOC401164、HSP90AA4P、FRG1、DUX4L9、FRG2、DUX2、DUX4L7、DUX4L6、DUX4L5、DUX4L4 、DUX4、DUX4L3、DUX4L2、PLEKHG4B、LRRC14B、CCDC127、SDHA、PDCD6、AHRR、C5orf55、EXOC3、PP7080、SLC9A3、LOC100288152、MIR4456、LOC100996325、C EP72、TPPP、LOC100996452、ZDHHC11、BRD9、TRIP13、LOC100506688、NKD2、SLC12A7、LOC100506766、MIR4635、SLC6A19、SLC6A18、TERT、MIR4457、CLPTM 1L、LOC100506791、SLC6A3、LPCAT1、SDHAP3、LOC728613、MIR4277、MRPL36、NDUFS6、IRX4、LOC100506858、IRX2、C5orf38、LOC285577、IRX1、LOC340094 ADAMTS16, KIAA0947, FLJ33360, MED10, UBE2QL1, LOC255167, NSUN2, SRD5A1, PAPD7, MIR4278, LOC442132, ADCY2, C5orf49, FASTKD3, MTRR, LOC729506, LOC100505738, MIR4458, SEMA5A, MIR4636, LOC100505806, SNORD123, TAS2R1, LOC285692, FAM173B, CCT5, CMBL, MARCH6, ROPN1L-AS1, ROPN1L, ANKRD3 3B、DAP、CTNND2、TAG、DNAH5、TRIO、LOC100133299、FAM105A、FAM105B、ANKH、LOC100130744、LOC100128508、MIR4637、FBXL7、MIR887、MARCH11、LOC401 176、ZNF622、FAM134B、MYO10、LOC285696、BASP1、LOC401177、CDH18、GUSBP1、LOC100506217、CDH12、PMCHL1、PRDM9、C5orf17、CDH10、LOC340107、CDH9LOC643401、LSP1P3、CDH6、DROSHA、C5orf22、PDZD2、MIR4279、GOLPH3、MTMR12、ZFR、MIR579、SUB1、NPR3、LOC340113、TARS、ADAMTS12、RXFP3、SLC45A2、AMACR、C1QTNF3-AMACR、C1QTNF3、LOC646652、LOC401180、RAI14、TTC23L、RAD1、BRIX1、DNAJC21、LOC100996421、AGXT2、PRLR、SPEF2、IL7R、CAPSL、LOC100506406、UGT3A1、UGT3A2、LMBRD2、MIR580、SKP2、NADKD1、RANBP3L、SLC1A3、LOC646719、NIPBL、C5orf42、NUP155、WDR70、GDNF、GDNF-AS1、EGFLAM、EGFLAM-AS4、EGFLAM-AS2、LIFR、LIFR-AS1、MIR3650、OSMR、RICTOR、FYB、C9、DAB2、PTGER4、TTC33、PRKAA1、LOC100506548、RPL37、SNORD72、CARD6、C7、HEATR7B2、C6、PLCXD3、OXCT1、C5orf51、FBXO4、GHR、CCDC152、SEPP1、LOC648987、ANXA2R、LOC153684、LOC100132356、ZNF131、NIM1、HMGCS1、CCL28、C5orf28、C5orf34、PAIP1、LOC100652772、NNT、FGF10、LOC100996444、LOC100506674、MRPS30、HCN1、EMB、PARP8、LOC100287592、LOC642366、ISL1、LOC100506329、PELO、ITGA1、ITGA2、MOCS2、LOC257396、FST、NDUFS4、ARL15、MIR581、MIR4459、HSPB3、SNX18、ESM1、GZMK、GZMA、CDC20B、GPX8、MIR449A、MIR449B、MIR449C、MCIN、CCNO、DHX29、SKIV2L2、PPAP2A、MIR5687、RNF138P1、SLC38A9、DDX4、IL31RA、IL6ST、FLJ31104、ANKRD55、LOC100509780、MAP3K1、SETD9、MIER3、GPBP1、ACTBL2、LOC100996645、PLK2、GAPT、MIR548AE2、RAB3C、PDE4D、MIR582、PART1、DEPDC1B、ELOVL7、ERCC8、NDUFAF2、C5orf43、ZSWIM6、C5orf64、LOC100506526、KIF2A、 DIMT1、IPO11、LRRC70、HTR1A、RNF180、RGS7BP、FAM159B、SREK1IP1、CWC27 、ADAMTS6、CENPK、PPWD1、TRIM23、C5orf44、SGTB、NLN、ERBB2IP、LOC100303 749、SREK1、MAST4、CD180、PIK3R1、SLC30A5、CCNB1、CENPH、MRPS36、CDK7、C CDC125、TAF9、RAD17、MARVELD2、OCLN、GTF2H2C、LOC100272216、LOC100652 783、GUSBP3、LOC728093、SERF1B、SMN2、LOC100170939、SMA4、GTF2H2B、SM A5、LOC100652799、SERF1A、SMN1、NAIP、GTF2H2、LOC647859、GUSBP9、PMCHL 2、BDP1、MCCC2、CARTPT、MAP1B、MIR4803、MRPS27、PTCD2、ZNF366、TNPO1、MI R4804、FCHO2、TMEM171、TMEM174、FOXD1、BTF3、ANKRA2、UTP15、ARHGEF28、E NC1、HEXB、GFM2、NSA2、FAM169A、LOC100996319、GCNT4、ANKRD31、HMGCR、C OL4A3BP、POLK、ANKDD1B、POC5、SV2C、IQGAP2、F2RL2、NCRUPAR、F2R、F2RL1、 S100Z、CRHBP、AGGF1、ZBED3、SNORA47、ZBED3-AS1、PDE8B、WDR41、OTP、TBCA 、AP3B1、LOC728769、SCAMP1、LHFPL2、ARSB、DMGDH、BHMT2、BHMT、JMY、HOMER 1, PAPD4, CMYA5, MTX3, THBS4, SERINC5, LOC644936, SPZ1, CRSP8P, ZFYVE16, FAM151B, ANKRD34B, DHFR, MTRNR2L2, MSH3, RASGRF2, CKMT2, LOC10013106 7、ZCCHC9、ACOT12、SSBP2、ATG10、RPS23、ATP6AP1L、FLJ41309、MIR3977、TM EM167A、SCARNA18、XRCC4、VCAN、HAPLN1、EDIL3、NBPF22P、COX7C、MIR3607、LOC100505878, MIR4280, RASA1, CCNH, TMEM161B, TMEM161B-AS1, LINC0046 1. MIR9-2, LOC100505949, MEF2C, MIR3660, CETN3, MBLAC2, POLR3G, LYSMD3 GPR98, LOC729040, LOC100505994, ARRDC3, ARRDC3-AS1, LOC100505822, F LJ42709, NR2F1, FAM172A, MIR2277, POU5F2, KIAA0825, ANKRD32, MCTP1, FAM 81B, TTC37, ARSK, GPR150, RFESD, SPATA9, RHOBTB3, GLRX, C5orf27, ELL2, M IR583, PCSK1, CAST, ERAP1, ERAP2, LNPEP, LIX1, RIOK2, RGMB, FLJ35946, CHD 1 LOC100289230 LOC100133050 FAM174A ST8SIA4 MIR548P SLCO4C1 SL CO6A1, PAM, GIN1, PPIP5K2, C5orf30, NUDT12, RAB9BP1, EFNA5, LOC10012923 3. FBXL17, HP07349, IRON, PJA2, MAN2A1, LOC100289673, TMEM232, MIR548F3 SLC25A46, TSLP, WDR36, CAMK4, STARD4, STARD4-AS1, NREP, NREP-AS1, EPB4 1L4A-AS1, SNORA13, EPB41L4A, FLJ11235, APC, SRP19, REEP5, DCP2, MCC, TS SK1B, YTHDC2, KCNN2, TRIM36, PGGT1B, CCDC112, FEM1C, TMED7-TICAM2, TICA M2, TMED7, CDO1, ATG12, AP3S1, AQPEP, ARL14EPL, COMMD10, SEMA6A, LOC728 342, LOC100505811, DTWD2, MIR1244-2, DMXL1, MIR5706, TNFAIP8, HSD17B4. FAM170A, PRR16, FTMT, SRFBP1, LOX, ZNF474, LOC100505841, SNCAIP, MGC32 805 SNX2 SNX24 PPIC PRDM6 CEP120 CSNK1G3 ZNF608 GRAMD3 ALDH7A1PHAX, C5orf48, LMNB1, MARCH3, C5orf63, MEGF10, PRRC1, CTXN3, LOC728586, FLJ33630, SLC12A2, FBN2, SLC27A6, ISOC1, MIR4633, MIR4460, ADAMTS19, KIAA1024L、CHSY3、HINT1、LYRM7、CDC42SE2、RAPGEF6、FNIP1、LOC728637、ACSL6、IL3、CSF2、P4HA2、PDLIM4、SLC22A4、LOC553103、MIR3936、SLC22A5、C5orf56、IRF1、IL5、RAD50、IL13、IL4、KIF3A、CCNI2、SEPT8、SOWAHA、SHROOM1、GDF9、UQCRQ、LEAP2、AFF4、ZCCHC10、HSPA4、LOC100506102、FSTL4、MIR1289-2、C5orf15、VDAC1、TCF7、SKP1、PPP2CA、MIR3661、CDKL3、UBE2B、CDKN2AIPNL、PHF15、SAR1B、SEC24A、CAMLG、DDX46、C5orf24、TXNDC15、PCBD2、MIR4461、CATSPER3、PITX1、LOC100996485、LOC340073、H2AFY、C5orf20、TIFAB、NEUROG1、CXCL14、LOC340074、MIR5692C1、SLC25A48、IL9、FBXL21、LECT2、TGFBI、VTRNA2-1、SMAD5-AS1、SMAD5、LOC389332、LOC100506219、TRPC7、SPOCK1、KLHL3、MIR874、HNRNPA0、NPY6R、MYOT、PKD2L2、FAM13B、LOC100130172、WNT8A、NME5、BRD8、KIF20A、CDC23、GFRA3、CDC25C、FAM53C、KDM3B、REEP2、EGR1、ETF1、HSPA9、SNORD63、CTNNA1、LRRTM2、SIL1、MATR3、SNHG4、SNORA74A、PAIP2、SLC23A1、MZB1、PROB1、SPATA24、DNAJC18、ECSCR、TMEM173、UBE2D2、CXXC5、PSD2、NRG2、LOC100505636、PURA、IGIP、CYSTM1、PFDN1、HBEGF、SLC4A9、ANKHD1、ANKHD1-EIF4EBP3、EIF4EBP3、SRA1、APBB3、SLC35A4、CD14、TMCO6、NDUFA2、IK、MIR3655、WDR55、DND1、HARS、HARS2、ZMAT2、VTRNA1-1、VTRNA1-2、VTRNA1-3、PCDHA1、PCDHA2、PCDHA3、PCDHA4、PCDHA5、PCDHA6、PCDHA7、PCDHA8、PCDHA9、PCDHA10、PCDHA11、PCDHA12、PCDHA13、PCDHAC1、PCDHAC2、PCDH B1、PCDHB2、PCDHB3、PCDHB4、PCDHB5、PCDHB6、PCDHB17、PCDHB7、PCDHB8、PCDHB16、PCDHB9、PCDHB10、PCDHB11、PCDHB12、PCDHB13、PCDHB14、PCDHB18、PCDHB DHB19P、PCDHB15、SLC25A2、TAF7、PCDHGA1、PCDHGA2、PCDHGA3、PCDHGB1、PCDHGA4、PCDHGB2、PCDHGA5、PCDHGB3、PCDHGA6、PCDHGA7、PCDHGB4、PCDHGA8、P CDHGB5、PCDHGA9、PCDHGB6、PCDHGA10、PCDHGB7、PCDHGA11、PCDHGB8P、PCDHGA12、PCDHGC3、PCDHGC4、PCDHGC5、DIAPH1、LOC100505658、HDAC3、RELL2、FC HSD1, ARAP3, PCDH1, LOC729080, KIAA0141, PCDH12, RNF14, GNPDA1, NDFIP1, SPRY4, FGF1, ARHGAP26, ARHGAP26-AS1, NR3C1, MIR5197, HMHB1, YIPF5, KCTD16, PRELID2, GRXCR2, SH3RF2, PLAC8L1, LARS, RBM27, POU4F3, TCERG1, GPR151, PPP2R2B, PPP2R2B-IT1, STK32A, DPYSL3, JAKMIP2-AS1, JAKMIP2, SPIN K1、SCGB3A2、C5orf46、SPINK5、SPINK14、SPINK6、SPINK13、SPINK7、SPINK9、FBXO38、HTR4、ADRB2、SH3TC2、MIR584、LOC255187、ABLIM3、AFAP1L1、GRPEL 2、PCYOX1L、IL17B、MIR143HG、MIR143、MIR145、CSNK1A1、ARHGEF37、PPARGC1B、MIR378A、PDE6A、SLC26A2、TIGD6、HMGXB3、CSF1R、PDGFRB、CDX1、SLC6A7、CAMK2A、ARSI、TCOF1、CD74、RPS14、NDST1、SYNPO、MYOZ3、RBM22、DCTN4、SMIM3、IRGM、ZNF300、ZNF300P1、GPX3、TNIP1、ANXA6、CCDC69、GM2A、SLC36A3、SLC36A2、SLC36A1、 FAT2, SPARC, ATOX1, LOC100652758, G3BP1, GLRA1, NMUR2, GRIA1, FAM114A2 MFAP3, GALNT10, MIR1294, FLJ38109, SAP30L, HAND1, MIR3141, MIR1303, L ARP1, C5orf4, MIR378H, CNOT8, GEMIN5, MRPL22, KIF4B, SGCD, PPP1R2P3, TI MD4、HAVCR1、HAVCR2、MED7、FAM71B、ITK、CYFIP2、FNDC9、NIPAL4、ADAM19、S OX30, C5orf52, THG1L, LSM11, CLINT1, LOC100507161, EBF1, RNF145, UBLCP 1、IL12B、LOC285626、LOC285627、ADRA1B、TTC1、PWWP2A、FABP6、CCNJL、C1Q TNF2, C5orf54, SLU7, PTTG1, MIR3142, MIR146A, ATP10B, LOC285629, GABRB 2、GABRA6、GABRA1、GABRG2、CCNG1、NUDCD2、HMMR、MAT2B、TENM2、WWC1、RARS、 FBLL1、PANK3、MIR103A1、MIR103B1、SLIT3、MIR218-2、LOC728095、MIR585、 SPDL1、DOCK2、FAM196B、LOC100133106、MIR378E、FOXI1、LOC100507267、C5 orf58、LCP2、LOC100128059、LOC257358、KCNIP1、KCNMB1、GABRP、RANBP17、 LOC728145, TLX3, MIR3912, NPM1, FGF18, FBXW11, STK10, EFCAB9, UBTD2, SH3 PXD2B, NEURL1B, MIR5003, DUSP1, ERGIC1, LOC100268168, RPL26L1, ATP6V0 E1, SNORA74B, CREBRF, BNIP1, NKX2-5, STC2, LOC285593, BOD1, CPEB4, C5or f47, HMP19, MSX2, MIR4634, FLJ16171, DRD1, SFXN1, HRH2, CPLX2, THOC3, LO C100996385、FAM153B、LOC100507387、LOC643201、SIMC1、KIAA1191、ARL10、MIR1271, NOP16, HIGD2A, CLTB, FAF2, RNF44, CDHR2, GPRIN1, SNCB, MIR4281, EIF4E1B, TSPAN17, UNC5A, HK3, UIMC1, ZNF346, FGFR4, NSD1, RAB24, PRELID1, MXD3, LMAN2, RGS14, SLC34A1, PFN3, F12, GRK6, PRR7-AS1, PRR7, DBN1, PDLIM7, DOK3, DDX41, FAM193B, TMED9, B4GALT7, LOC202181, LOC100507427, FA M153A、LOC728554、LOC100128340、PROP1、FAM153C、N4BP3、RMND5B、NHP2、GMCL1P1、HNRNPAB、AGXT2L2、COL23A1、CLK4、ZNF354A、AACSP1、ZNF354B、ZFP2 、ZNF454、GRM6、ZNF879、ZNF354C、ADAMTS2、RUFY1、HNRNPH1、C5orf60、CBY3、CANX、MAML1、LTC4S、MGAT4B、MIR1229、SQSTM1、C5orf45、LOC100996419、TB C1D9B、RNF130、MIR340、RASGEF1C、MAPK9、LOC100996424、GFPT2、CNOT6、SCGB3A1、FLT4、OR2Y1、MGAT1、LOC100859930、LOC729678、ZFP62、BTNL3 、BTNL9、OR2V1、OR2V2、TRIM7、LOC100507546、MIR4638、TRIM41、GNB2L1、SNORD96A、SNORD95、TRIM52、LOC100507602、LOC100996446、LOC100132062、LOC C100286914、OR4F3、FLJ43763、DUSP22、IRF4、EXOC2、HUS1B、LOC285768、FOXQ1、FOXF2、FOXC1、GMDS、LOC100508120、C6orf195、MYLK4、WRNIP1、SERPINB 1、MIR4645、MGC39372、SERPINB9、SERPINB6、DKFZP686I15217、NQO2、HTATSF1P2、RIPK1、BPHL、TUBB2A、LOC100507194、TUBB2B、PSMG4、SLC22A23、PXDC1、FAM50B、PRPF4B、FAM217A、C6orf201、ECI2、LOC100507506、KU-MEL-3、CDYL、RPP40、LOC100129461、LOC100129033、PPP1R3G、LYRM4、MIR3691、FARS2、NRN1、F13A1、MIR5683、 LY86-AS1, LY86, RREB1, SSR1, CAGE1, RIOK1, DSP, SNRNP48, BMP6, TXNDC5, BLOC1S5-TXNDC5, PIP5K1P1, BLOC1S5, EEF1E1-MUTED, EEF1E1, SCARNA27, LOC100506091, SLC35B3, LOC100506207, HULC, LOC100506288, OFCC1, TFAP2A, LOC100130275, LINC00518, MIR5689, GCNT2, C6orf52, PAK1IP1, TMEM14C, LOC100506379、TMEM14B、MAK、GCM2、SYCP2L、ELOVL2、ELOVL2-AS1、C6orf228、ERVFRD-1、NEDD9、LOC100506431、TMEM170B、ADTRP、HIVEP1、EDN1、PHACT R1、LOC100130357、TBC1D7、GFOD1、SIRT5、NOL7、RANBP9、CCDC90A、RNF182、CD83、LOC100506631、LOC100506647、JARID2、JARID2-AS1、DTNBP1、MYLIP、 MIR4639、GMPR、ATXN1、FLJ23152、RBM24、CAP2、FAM8A1、NUP153、KIF13A、LOC100996300、NHLRC1、TPMT、KDM1B、DEK、RNF144B、MIR548A1、LOC100506885 , ID4, MBOAT1, E2F3, CDKAL1, SOX4, LINC00340, LOC729177, PRL, HDGFL1, NRSN1, DCDC2, KAAG1, MRS2, GPLD1, ALDH5A1, KIAA0319, TDP2, ACOT13, C6orf6 2、GMNN、FAM65B、CMAHP、LRRC16A、SCGN、HIST1H2AA、HIST1H2BA、HIST1H2APS1、SLC17A4、SLC17A1、SLC17A3、SLC17A2、TRIM38、HIST1H1A、HIST1H3A、HI ST1H4A、HIST1H4B、HIST1H3B、HIST1H2AB、HIST1H2BB、HIST1H3C、HIST1H1C、HFE、HIST1H4C、HIST1H1T、HIST1H2BC、HIST1H2AC、HIST1H1E、HIST1H2BD、HIST1H2BE、HIST1H4D、HIST1H3D、HIST1H2AD、HIST1H2BF、HIST1H4E、HIST1 H2BG、HIST1H2AE、HIST1H3E、HIST1H1D、HIST1H4F、HIST1H4G、HIST1H3F、HI ST1H2BH, HIST1H3G, HIST1H2BI, HIST1H4H, BTN3A2, BTN2A2, BTN3A1, BTN2A 3P, BTN3A3, BTN2A1, LOC285819, BTN1A1, HCG11, HMGN4, ABT1, ZNF322, GUSBP 2 LINC00240 LOC100270746 HIST1H2BJ HIST1H2AG HIST1H2BK HIST1H4 I, HIST1H2AH, MIR3143, PRSS16, POM121L2, VN1R10P, ZNF204P, ZNF391, ZNF 184 LOC100507173 LOC100131289 HIST1H2BL HIST1H2AI HIST1H3H HIS T1H2AJ, HIST1H2BM, HIST1H4J, HIST1H4K, HIST1H2AK, HIST1H2BN, HIST1H2A L, HIST1H1B, HIST1H3I, HIST1H4L, HIST1H3J, HIST1H2AM, HIST1H2BO, OR2B 2, OR2B6, ZNF165, ZSCAN12P1, ZSCAN16, ZNF192, TOB2P1, ZNF193, ZKSCAN4 NKAPL, ZNF187, PGBD1, ZNF323, ZKSCAN3, ZSCAN12, ZSCAN23, GPX6, GPX5, SC AND3, LOC401242, TRIM27, ZNF311, LOC100129636, OR2W1, OR2B3, OR2J3, OR2 J2, OR14J1, OR5V1, OR12D3, OR12D2, OR11A1, OR10C1, OR2H1, MAS1L, LOC100 507362, UBD, SNORD32B, OR2H2, GABBR1, MOG, ZFP57, HLA-F, HLA-F-AS1, IFI TM4P, HCG4, LOC554223, HLA-G, HLA-H, HCG4B, HLA-A, HCG9, ZNRD1-AS1, HLA -J、HCG8、ZNRD1、PPP1R11、RNF39、TRIM31、TRIM40、TRIM10、TRIM15、TRIM26.HCG17、HLA-L、HCG18、TRIM39、TRIM39-RPP21、RPP21、HLA-E、GNL1、PRR3、ABCF1、MIR877、PPP1R10、MRPS18B、ATAT1、C6orf136、DHX16、PPP1R18、NRM、MDC1、TUBB、FLOT1、IER3、LINC00243、DDR1、 MIR4640、GTF2H4、VARS2、SFTA2、DPCR1、MUC21、MUC22、HCG22、C6orf15、PSORS1C1、CDSN、PSORS1C2、CCHCR1、TCF19、POU5F1、PSORS1C3、HCG27、LOC100996357、HLA-C、HLA-B、MICA、HCP5、HCG26、MICB、MCCD1、ATP6V1G2-DDX39B、DDX39B、SNORD117、SNORD84、ATP6V1G2、NFKBIL1、LOC100287329、LTA、TNF、LTB、LST1、NCR3、AIF1、PRRC2A、SNORA38、BAG6、APOM、C6orf47、GPANK1、CSNK2B、LY6G5B、LY6G5C、ABHD16A、MIR4646、LY6G6F、LY6G6E、LY6G6D、LY6G6C、C6orf25、DDAH2、CLIC1、MSH5、MSH5-SAPCD1、SAPCD1、VWA7、VARS、LSM2、HSPA1L、HSPA1A、HSPA1B、C6orf48、SNORD48、SNORD52、NEU1、SLC44A4、EHMT2、C2、ZBTB12、CFB、RDBP、MIR1236、SKIV2L、DOM3Z、STK19、C4A、CYP21A1P、TNXA、C4B、CYP21A2、TNXB、ATF6B、FKBPL、PRRT1、LOC100507547、PPT2、PPT2-EGFL8、EGFL8、AGPAT1、RNF5、AGER、PBX2、GPSM3、NOTCH4、C6orf10、HCG23、BTNL2、HLA-DRA、HLA-DRB5、HLA-DRB6、HLA-DRB1、HLA-DQA1、HLA-DQB1、HLA-DQA2、MIR3135B、HLA-DQB2、HLA-DOB、TAP2、PSMB8、LOC100507463、TAP1、PSMB9、LOC100294145、HLA-DMB、HLA-DMA、BRD2、HLA-DOA、HLA-DPA1、HLA-DPB1、HLA-DPB2、COL11A2、RXRB、SLC39A7、HSD17B8、MIR219-1、RING1、HCG25、VPS52、RPS18、B3GALT4、WDR46、PFDN6、RGL2、TAPBP、ZBTB22、DAXX、KIFC1、PHF1、CUTA、SYNGAP1、MIR5004、ZBTB9、BAK1、GGNBP1、LINC00336、ITPR3、MNF1、MIR3934、IP6K3、LEMD2、MLN、LOC100507584、LOC100653005、MIR1275、GRM4、HMGA1、C6orf1、NUDT3、RPS10-NUDT3、RPS10、PACSIN1、SPDEF、C6orf106、SNRPC、UHRF1BP1、TAF11、ANKS1A、TCP11、SCUBE3、ZNF76、DEF6、PPARD、LOC100507672、FANCE、RPL10A、TEAD3、TULP1、FKBP5、MIR5690、LOC285847、ARMC12、CLPSL2、CLPSL1、CLPS、LHFPL5、SRPK1、SLC26A8、MAPK14、MAPK13、BRPF3、PNPLA1、C6orf222、ETV7、PXT1、KCTD20、STK38、SRSF3、MIR3925、CDKN1A、RAB44、CPNE5、PPIL1、C6orf89、PI16、MTCH1、FGD2、PIM1、TMEM217、TBC1D22B、RNF8、FTSJD2、CCDC167、FLJ45825、LOC100505550、MIR4462、MDGA1、ZFAND3、BTBD9、GLO1、DNAH8、LOC100131047、GLP1R、SAYSD1、KCNK5、KCNK17、KCNK16、KIF6、DAAM2、LOC100505635、MOCS1、FLJ41649、TDRG1、LRFN2、LOC100505697、UNC5CL、TSPO2、APOBEC2、OARD1、NFYA、ADCY10P1、TREML1、TREM2、TREML2、TREML3P、TREML4、TREML5P、TREM1、NCR2、LOC100505711、FOXP4、MIR4641、MDFI、TFEB、PGC、FRS3、PRICKLE4、TOMM6、USP49、MED20、BYSL、CCND3、TAF8、C6orf132、GUCA1A、GUCA1B、MRPS10、TRERF1、UBR2、PRPH2、ATP6V0CP3、TBCC、KIAA0240、RPL7L1、C6orf226、PTCRA、CNPY3、GNMT、PEX6、PPP2R5D、MEA1、KLHDC3、RRP36、CUL7, MRPL2, KLC4, PTK7, SRF, CUL9, C6orf108, TTBK1, SLC22A7, CRIP3, ZNF318, ABCC10, DLK2, TJAP1, LRRC73, YIPF3, POLR1C, XPO5, POLH GTPBP2、MAD2L1BP、RSPH9、MRPS18A、VEGFA、LOC100132354、C6orf223、MRPL14、TMEM63B、CAPN11、SLC29A1、HSP90AB1、SLC35B2、MIR4647、NFKBIE、TMEM 151B、TCTE1、AARS2、SPATS1、CDC5L、MIR4642、LOC100505862、SUPT3H、MIR586、RUNX2、CLIC5、ENPP4、ENPP5、RCAN2、CYP39A1、SLC25A27、TDRD6、PLA2G7 LOC100287718、MEP1A、GPR116、GPR110、TNFRSF21、CD2AP、GPR111、GPR115、OPN5、PTCHD4、MUT、CENPQ、GLYATL3、C6orf141、RHAG、CRISP2、PGK2 、CRISP1、DEFB133、DEFB114、DEFB113、DEFB110、DEFB112、LOC100505985、TFAP2D、TFAP2B、PKHD1、MIR206、MIR133B、IL17A、IL17F、MCM3、PAQR8、EFHC1 TRAM2、FLJ37798、LOC730101、TMEM14A、GSTA7P、GSTA2、GSTA1、GSTA5、GSTA3、GSTA4、RN7SK、ICK、FBXO9、GCM1、ELOVL5、MIR5685、RPS16P5、GCLC、KLHL3 1、LRRC1、MLIP-IT1、MLIP、TINAG、FAM83B、HCRTR2、GFRAL、HMGCLL1、BMP5、COL21A1、DST、LOC100652766、BEND6、KIAA1586、ZNF451、BAG2、RAB23、LOC100 506188、MIR548U、GUSBP4、LOC100996497、KHDRBS2、LGSN、PTP4A1、PHF3、EYS、SLC25A51P1、LOC100996552、BAI3、LMBRD1、COL19A1、COL9A1、LOC100507 172、FAM135A、C6orf57、SMAP1、B3GAT2、OGFRL1、LOC100507367、MIR30C2、MIR30A、LINC00472、RIMS1、KCNQ5、KCNQ5-IT1、MIR4282、KCNQ5-AS1、KHDC1LKHDC1、C6orf147、DPPA5、KHDC3L、OOEP、DDX43、MB21D1、MTO1、EEF1A1、SLC17A5、CD109、COL12A1、COX7A2、TMEM30A、LOC100506804、FILIP1、MIR4463 SENP6、MYO6、IMPG1、HTR1B、IRAK1BP1、PHIP、HMGN3、LOC100288198、LOC100506851、LCA5、SH3BGRL2、C6orf7、ELOVL4、TTK、BCKDHB、FAM46A、IBTK、TPBG 、UBE3D、DOPEY1、PGM3、RWDD2A、ME1、PRSS35、SNAP91、RIPPLY2、CYB5R4、LOC100506908、MRAP2、KIAA1009、LOC100506926、TBX18、NT5E、SNX14、SYNCRI P、SNHG5、SNORD50A、SNORD50B、HTR1E、CGA、ZNF292、GJB7、C6orf162、C6orf163、C6orf164、C6orf165、SLC35A1、RARS2、ORC3、AKIRIN2、SPACA1、CNR1、R NGTT、PNRC1、SRSF12、PM20D2、GABRR1、GABRR2、UBE2J1、RRAGD、ANKRD6、LYRM2、MDN1、CASP8AP2、GJA10、LOC100507024、BACH2、MIR4464、MAP3K7、MIR4 643、EPHA7、TSG1、MANEA、FUT9、UFL1、FHL5、GPR63、NDUFAF4、KLHL32、MMS22L、MIR2113、POU3F2、FBXL4、MIR548AI、FAXC、COQ3、PNISR、USP45、TSTD3、CC NC, PRDM13, MCHR2, LOC728012, SIM1, ASCC3, GRIK2, HACE1, LINC00577, LIN28B, BVES, BVES-AS1, POPDC3, PREP, PRDM1, ATG5, LOC100506165, AIM1, RTN4IP1, QRSL1, LOC100422737, MIR587, C6orf203, BEND3, PDSS2, SOBP, SCML4, SEC63, OSTM1, OSTM1-AS1, NR2E1, SNX3, LACE1, FOXO3, LINC00222, ARMC2,LOC100506276、SESN1、CEP57L1、C6orf183、LOC100996634、CCDC162P、LOC100996641、CD164、PPIL6、SMPD2、MICAL1、ZBTB24、AKD1、FIG4、GPR6、WASF1、 CDC40、METTL24、DDO、SLC22A16、CDK19、AMD1、GTF3C6、RPF2、GSTM2P1、SLC16A10、KIAA1919、REV3L、TRAF3IP2-AS1、TRAF3IP2、FYN、LOC100506389、WISP3、TUBE1、C6orf225、LAMA4、RFPL4B、LOC100287612、LOC100652953、MARCKS、LOC285758、FLJ34503、HDAC2、HS3ST5、LOC441167、FRK、TPI1P3、NT5DC1、COL10A1、TSPYL4、LOC100506496、TSPYL1、DSE、FAM26F、BET3L、FAM26E、FAM26D、RWDD1、RSPH4A、ZUFSP、KPNA5、FAM162B、GPRC6A、RFX6、VGLL2、ROS1、DCBLD1、GOPC、NUS1、SLC35F1、CEP85L、BRD7P3、PLN、LOC100287632、MCM9、ASF1A、FAM184A、MIR548B、MAN1A1、LOC285762、MIR3144、C6orf170、GJA1、HSF2、SERINC1、PKIB、FABP7、SMPDL3A、CLVS2、TRDN、NKAIN2、STL、RNF217、TPD52L1、HDDC2、LOC643623、HEY2、NCOA7、HINT3、TRMT11、LOC100507136、CENPW、MIR588、RSPO3、RNF146、ECHDC1、SOGA3、KIAA0408、C6orf58、THEMIS、PTPRK、LAMA2、ARHGAP18、TMEM244、L3MBTL3、SAMD3、TMEM200A、LOC100507203、EPB41L2、AKAP7、ARG1、MED23、ENPP3、OR2A4、CTAGE9、MIR548H5、ENPP1、CTGF、MIR548AJ1、LOC100507254、MOXD1、STX7、TAAR9、TAAR8、TAAR6、TAAR5、TAAR3、TAAR2、TAAR1、VNN1、VNN3、VNN2、SLC18B1、RPS12、SNORD101、SNORD100、SNORA33、LINC00326、EYA4、LOC100507308、MGC34034、TCF21、TBPL1、SLC2A12、HMGA1P7、SGK1、LOC154092、ALDH8A1、HBS1L、MIR3662、MYB、MIR548A2、AHI1、LINC00271、PDE7B、LOC644135、FAM54A、BCLAF1、MAP7、MAP3K5、PEX7、SLC35D3、NHEG1、IL20RA、IL22RA2、IFNGR1、OLIG3、LOC100507406、LOC100130476、TNFAIP3、PERP、KIAA1244、PBOV1、HEBP2、NHSL1、MIR3145、FLJ46906、LOC100507462、CCDC28A、ECT2L、REPS1、ABRACL、HECA、TXLNB、CITED2、LOC645434、LOC100132735、LOC100507477、MIR3668、MIR4465、NMBR、VTA1、GPR126、LOC153910、HIVEP2、LOC100507489、AIG1、ADAT2、PEX3、FUCA2、LOC285740、PHACTR2、LTV1、ZC2HC1B、PLAGL1、HYMAI、SF3B5、STX11、UTRN、EPM2A、LOC100507557、FBXO30、SHPRH、GRM1、RAB32、ADGB、LOC729176、STXBP5-AS1、STXBP5、SAMD5、SASH1、UST、LOC100128176、TAB2、SUMO4、ZC3H12D、PPIL4、GINM1、KATNA1、LATS1、NUP43、PCMT1、LRP11、LOC100652739、RAET1E、RAET1G、ULBP2、ULBP1、RAET1K、RAET1L、ULBP3、PPP1R14C、IYD、PLEKHG1、MTHFD1L、AKAP12、ZBTB2、RMND1、C6orf211、CCDC170、ESR1、SYNE1、SYNE1-AS1、MYCT1、VIP、FBXO5、MTRF1L、RGS17、LOC100996290、OPRM1、IPCEF1、CNKSR3、SCAF8、MIR1273C、LOC100505519、TIAM2、TFB1M、CLDN20、NOX3、MIR1202、ARID1B、MIR4466、TMEM242、ZDHHC14、MIR3692、SNX9、SYNJ2、SYNJ2-IT1、SERAC1、GTF2H5、TULP4、TMEM181、DYNLT1、SYTL3、MIR3918、EZR、OSTCP1、C6orf99、RSPH3、TAGAP、FNDC1、FLJ27255、SOD2、WTAP、LOC100129518、ACAT2、TCP1、SNORA20、SNORA29、MRPL18、 PNLDC1、MAS1、IGF2R、AIRN、LOC729603、SLC22A1、SLC22A2、SLC22A3、LPAL2、LPA、PLG、MAP3K4、AGPAT4、AGPAT4-IT1、PARK2、PACRG、LOC729658、PACRG- AS1、DKFZp451B082、CAHM、QKI、C6orf118、PDE10A、SDIM1、LINC00473、LINC00602、T、PRR18、SFT2D1、LOC100289495、MPC1、RPS6KA2、RPS6KA2-IT1、MIR1 913、RNASET2、MIR3939、FGFR1OP、CCR6、GPR31、TCP10L2、UNC93A、TTLL2、TCP10、LOC729995、LOC401286、C6orf123、LOC441179、MLLT4-AS1、MLLT4、HGC 6.3、KIF25-AS1、KIF25、FRMD1、DACT2、SMOC2、THBS2、WDR27、C6orf120、PHF10、TCTE3、C6orf70、LINC00242、LINC00574、LOC100505903、LOC154449、DLL 1, FAM120B, MIR4644, PSMB1, TBP, PDCD2, LOC100132858, LOC100507642, FAM20C, LOC100996433, LOC100288524, LOC442497, LOC100131372, PDGFA, FLJ44511, PRKAR1B, HEATR2, SUN1, GET4, ADAP1, COX19, CYP2W1, C7orf50, MIR339, GPR146, GPER, ZFAND2A, UNCX, MICALL2, LOC100996269, INTS1, MAFK, LO C100128653、TMEM184A、PSMG3、PSMG3-AS1、TFAMP1、LOC401296、ELFN1、MAD1L1、LOC100128374、MIR4655、FTSJ2、NUDT1、SNX8、EIF3B、CHST12、LOC10028 8594、LFNG、MIR4648、BRAT1、IQCE、TTYH3、AMZ1、GNA12、CARD11、SDK1、FOXK1、AP5Z1、MIR4656、RADIL、PAPOLB、MMD2、RNF216P1、RBAK、RBAK-LOC389458、LOC389458、ZNF890P、WIPI2、SLC29A4、TNRC18、LOC100129484、FBXL18、MIR589、ACTB、FSCN1、RNF216、RNF216-IT1、ZNF815P、OCM、CCZ1、RSPH10B、PMS2 、AIMP2、EIF2AK1、USP42、CYTH3、FAM220A、RAC1、DAGLB、KDELR2、GRID2IP、ZDHHC4、C7orf26、ZNF853、ZNF12、LOC100505863、PMS2CL、RSPH10B2、CCZ1B、M IR3683、LOC100131257、C1GALT1、LOC100505904、COL28A1、MIOS、RPA3、LOC729852、LOC100505921、GLCCI1、ICA1、LOC100505938、NXPH1、PER4、NDUFA4 、PHF14、THSD7A、TMEM106B、VWDE、SCIN、ARL4A、ETV1、DGKB、AGMO、MEOX2、ISPD、LOC100506025、SOSTDC1、LRRC72、ANKMY2、BZW2、TSPAN13、AGR2、AGR3、AH R、SNX13、PRPS1L1、HDAC9、MIR1302-6、TWIST1、FERD3L、TWISTNB、MIR3146、TMEM196、MACC1、MACC1-AS1、LOC100506098、ITGB8、ABCB5、SP8、RPL23P8、S P4, MIR1183, DNAH11, CDCA7L, RAPGEF5, STEAP1B, LOC100506178, LOC401312, LOC541472, IL6, TOMM7, SNORD93, FAM126A, KLHL7-AS1, KLHL7, NUPL2, GPN MB, MALSU1, IGF2BP3, RPS2P32, TRA2A, CLK2P, CCDC126, FAM221A, STK31, NPY, MPP6, DFNA5, OSBPL3, CYCS, C7orf31, NPVF, LOC100506236, LOC100996355, MIR148A, NFE2L3, HNRNPA2B1, CBX3, SNX10, LOC441204, KIAA0087, LOC100506289, C7orf71, SKAP2, HOXA1, HOTAIRM1, HOXA2, HOXA3, HOXA-AS2, HOXA4,HOXA-AS3、HOXA5、HOXA6、HOXA7、HOXA9、HOXA10-HOXA9、HOXA-AS4、MIR196B、HOXA10、H OXA11, HOXA11-AS, HOXA13, HOTTIP, EVX1, HIBADH, TAX1BP1, JAZF1, JAZF1-AS1, CREB5 LOC401317, TRIL, LOC100506497, CPVL, CHN2, PRR15, LOC646762, MIR550A3, ZNRF2P2, DPY19L2P3, WIPF3, SCRN1, FKBP14, PLEKHA8, C7orf41, ZNRF2, MI R550A1、MIR550B1、DKFZP586I1420、LOC100506516、NOD1、GGCT、LOC401320 、GARS、CRHR2、INMT、INMT-FAM188B、FAM188B、AQP1、GHRHR、ADCYAP1R1、NEUR OD6、CCDC129、PPP1R17、PDE1C、LOC100130673、LSM5、AVL9、DPY19L1P1、ZNR F2P1、MIR550B2、MIR550A2、LOC401321、KBTBD2、RP9P、FKBP9、NT5C3、RP9、BB S9、FLJ20712、BMPER、NPSR1-AS1、NPSR1、DPY19L1、MIR548N、DPY19L2P1、TB 20 、ANLN、AOAH、AOAH-IT1、ELMO1、MIR1200、GPR141、NME8、SFRP4、EPDR1、STAR D3NL、TARP、LOC100506776、AMPH、FAM183B、VPS41、POU6F2、POU6F2-AS1、YA E1D1、LOC100996411、LOC646999、RALA、LINC00265、CDK13、MPLKIP、C7orf1 0、INHBA、INHBA-AS1、GLI3、C7orf25、PSMA2、MRPL32、HECW1、HECW1-IT1、MIR 3943、LOC100506895、STK17A、COA1、BLVRA、URGCP-MRPS24、MRPS24、URGCP、 UBE2D4、POLR2J4、SPDYE1、RASA4CP、FLJ35390、DBNL、PGAM2、POLM、AEBP1、MI R4649, POLD2, MYL7, GKK, YKT6, CAMK2B, NUDCD3, NPC1L1, DDX56, TMED4, OGDH, ZMIZ2, PPIA, H2AFV, PURB, MIR4657, MYO1G, SNHG15, SNORA9, CCM2, NACADTBRG4、SNORA5A、SNORA5C、SNORA5B、RAMP3、ADCY1、SEPT7P2、IGFBP1、IGFBP3、TNS3、C7orf65、LINC00525、PKD1L1、C7orf69、HUS1、SUN3、C7orf57、UPP1、ABCA13、CDC14C、VWC2、ZPBP、C7orf72、IKZF1、FIGNL1、DDC、LOC100129427、GRB10、COBL、LOC730378、POM121L12、FLJ45974、HPVC1、VSTM2A、LOC285878、SEC61G、LOC100996654、EGFR、EGFR-AS1、LANCL2、VOPP1、FKBP9L、LOC730376、LOC100128326、SEPT14、ZNF713、MRPS17、GBAS、PSPH、CCT6A、SNORA15、SUMF2、PHKG1、CHCHD2、NUPR1L、LOC100507369、LOC650226、DKFZp434L192、LOC100996261、LOC100996271、LOC100996278、LOC100130849、LOC100287294、MIR4283-1、ZNF479、GUSBP10、MIR3147、ZNF716、LOC100287633、ZNF733P、LOC100287704、LOC100287834、MIR4283-2、LOC402269、LOC100287894、LOC100996408、LOC100996423、LOC100996380、LOC100506050、ZNF727、ZNF735、ZNF679、ZNF736、LOC649395、ZNF680、LOC641746、ZNF107、ZNF138、ZNF273、ZNF117、ERV3-1、CCT6P3、ZNF92、LOC441242、INTS4L2、LOC100996422、CCT6P1、SNORA22、DKFZP434F142、VKORC1L1、GUSB、ASL、CRCP、TPST1、LINC00174、LOC100289098、LOC493754、KCTD7、LOC100996437、RABGEF1、GTF2IRD1P1、LOC644794、TMEM248、SBDS、TYW1、MIR4650-1、PMS2P4、STAG3L4、LOC100507468、AUTS2、WBSCR17、MIR3914-1、MIR3914-2、CALN1、TYW1B、MIR4650-2、SBDSP1、SPDYE7P、POM121、NSUN5P2、TRIM74、STAG3L3、SPDYE8P、LOC100093631、NCF1B、GTF2IRD2P1、 NSUN5、TRIM50、FKBP6、FZD9、BAZ1B、BCL7B、TBL2、MLXIPL、VPS37D、DNAJC30 、WBSCR22、STX1A、MIR4284、ABHD11-AS1、ABHD11、CLDN3、CLDN4、LOC1009964 51、WBSCR27、WBSCR28、ELN、LIMK1、EIF4H、MIR590、LAT2、RFC2、CLIP2、GTF2 IRD1、GTF2I、NCF1、GTF2IRD2、STAG3L2、PMS2P5、GATSL1、LOC100505669、WBS CR16、GTF2IRD2B、NCF1C、GTF2IP1、GATSL2、PMS2L2、STAG3L1、LOC541473、T RIM73、NSUN5P1、POM121C、SPDYE5、PMS2P3、HIP1、CCL26、CCL24、RHBDD2、POR 、MIR4651、SNORA14A、TMEM120A、STYXL1、MDH2、SRRM3、HSPB1、YWHAG、SRCRB 4D、ZP3、DTX2、FDPSL2A、UPK3B、LOC100288807、LOC100133091、POMZP3、DTX2 P1-UPK3BP1-PMS2P11、LOC100132832、LOC100505767、CCDC146、FGL2、PION 、PTPN12、RSBN1L-AS1、RSBN1L、TMEM60、PHTF2、MAGI2、RPL13AP17、MAGI2-AS 2, MAGI2-AS3, GNAI1, GNAT3, CD36, SEMA3C, HGF, CACNA2D1, PCLO, SEMA3E, SEMA3A, SEMA3D, LOC100505913, GRM3, KIAA1324L, DMTF1, C7orf23, TP53TG1, CROT、ABCB4、ABCB1、RUNDC3B、SLC25A40、DBF4、ADAM22、SRI、STEAP4、ZNF80 4B、C7orf62、DPY19L2P4、STEAP1、STEAP2、C7orf63、GTPBP10、CLDN12、LOC10 0996527、CDK14、FZD1、MTERF、AKAP9、CYP51A1、LOC613126、LRRD1、KRIT1、M IR1285-1、ANKIB1、GATAD1、ERVW-1、PEX1、RBM48、MGC16142、FAM133B、CDK6、RNU6-10、SAMD9、SAMD9L、HEPACAM2、CCDC132、CALCR、MIR653、MIR489、MIR4 652、TFPI2、GNGT1、GNG11、BET1、COL1A2、CASD1、SGCE、PEG10、PPP1R9A、PON 1、PON3、PON2、ASB4、LOC100996577、PDK4、DYNC1I1、SLC25A13、MIR591、FLJ 42280、LOC100506136、SHFM1、DLX6-AS1、DLX6、DLX5、ACN9、TAC1、ASNS、MIR5 692A1、MIR5692C2、MGC72080、OCM2、LMTK2、BHLHA15、TECPR1、BRI3、BAIAP2 L1、FLJ30064、NPTX2、TMEM130、TRRAP、MIR3609、SMURF1、KPNA7、MYH16、ARPC 1A、ARPC1B、PDAP1、BUD31、PTCD1、ATP5J2-PTCD1、CPSF4、ATP5J2、ZNF789、Z NF394、ZKSCAN5、FAM200A、ZNF655、LOC100289187、ZNF498、CYP3A5、CYP3A7- CYP3AP1、CYP3A7、CYP3A4、CYP3A43、OR2AE1、TRIM4、GJC3、AZGP1、AZGP1P1、 ZKSCAN1、ZSCAN21、ZNF3、COPS6、MCM7、MIR25、MIR93、MIR106B、AP4M1、TAF6 、CNPY4、MBLAC1、LAMTOR4、C7orf43、MIR4658、GAL3ST4、GPC2、STAG3、GATS、 PVRIG、SPDYE3、PMS2P1、PILRB、PILRA、ZCWPW1、MEPCE、PPP1R35、C7orf61、TS C22D4, NYAP1, AGFG2, SAP25, LRCH4, FBXO24, PCOLCE-AS1, PCOLCE, MOSPD3, TFR2, ACTL6B, GNB2, GIGYF1, POP7, EPO, ZAN, EPHB4, SLC12A9, TRIP6, SRRT, U FSP1、ACHE、MUC12、MUC17、TRIM56、SERPINE1、AP1S1、MIR4653、VGF、NAT16、 MOGAT3、PLOD3、ZNHIT1、CLDN15、FIS1、RABL5、EMID2、LOC100506527、MYL10、CUX1、SH2B2、MIR4285、SPDYE6、LOC100630923、LOC100289561、PRKRIP1、MIR548O、ORAI2、ALKBH4、LRWD1、MIR5090、MIR4467、POLR2J、RASA4B、POLR2J3、SPDYE2、RASA4、 POLR2J2、UPK3BL、SPDYE2L、FAM185A、FBXL13、LRRC17、NFE4、ARMC10、NAPEP LD、RPL19P12、DPY19L2P2、PMPCB、DNAJC2、PSMC2、SLC26A5、RELN、ORC5、LHFP L3, LHFPL3-AS1, LHFPL3-AS2, LOC100216546, LOC100216545, MLL5, SRPK2, PUS7, RINT1, EFCAB10, ATXN7L1, CDHR3, SYPL1, NAMPT, CCDC71L, PIK3CG, PRK AR2B、HBP1、COG5、GPR22、DUS4L、BCAP29、SLC26A4-AS1、SLC26A4、CBLL1、SL C26A3、DLD、LAMB1、LAMB4、NRCAM、PNPLA8、THAP5、DNAJB9、C7orf66、EIF3IP1 、IMMP2L、LRRN3、DOCK4、LOC100506413、ZNF277、IFRD1、C7orf53、LOC10099 6249、TMEM168、C7orf60、GPR85、LOC401397、TSRM、PPP1R3A、FOXP2、MIR3666 、MDFIC、LOC100506489、TFEC、TES、CAV2、CAV1、LOC100996266、MET、CAPZA2 、ST7-AS1、ST7、ST7-OT4、ST7-AS2、ST7-OT3、WNT2、ASZ1、CFTR、CTTNBP2、NAA 38、ANKRD7、KCND2、TSPAN12、ING3、CPED1、WNT16、FAM3C、PTPRZ1、AASS、FEZ F1、FEZF1-AS1、CADPS2、RNF133、RNF148、TAS2R16、SLC13A1、IQUB、NDUFA5、A SB15、LMOD2、WASL、HYALP1、HYAL4、SPAM1、TMEM229A、GPR37、LOC154872、PO T1、LOC100506664、GRM8、MIR592、ZNF800、LOC100506682、GCC1、ARF5、FSCN3 、PAX4、SND1、SND1-IT1、LRRC4、MIR593、MIR129-1、LEP、MGC27345、RBM28、PR RT4、IMPDH1、HILPDA、METTL2B、FLJ45340、FAM71F2、FAM71F1、CALU、OPN1SW、CCDC136, FLNC, ATP6V1F, LOC100130705, KCP, IRF5, TNPO3, TPI1P2, LOC407835, TSPAN33, SMO, AHCYL2, STRIP2, LOC100287482, NRF1, RNA5SP244, MIR182, MIR96, MIR183, UBE2H, ZC3HC1, KLHDC10, TMEM209, C7orf45, CPA2, CPA4, CPA5, CPA1, CEP41, MEST, MESTIT1, MIR335, COPG2, TSGA13, KLF14, MIR29A, MIR29B1、LOC646329、LOC100506860、FLJ43663、MKLN1、LOC100506881、PODXL、PLXNA4、FLJ40288、LOC100506937、CHCHD3、MIR3654、EXOC4、LRGUK、SLC3 5B4、AKR1B1、AKR1B10、AKR1B15、BPGM、CALD1、AGBL3、LOC653739、TMEM140、C7orf49、WDR91、STRA8、CNOT4、NUP205、C7orf73、SLC13A4、FAM180A、LUZP6、 MTPN、CHRM2、LOC349160、MIR490、PTN、DGKI、NAG20、CREB3L2、LOC100130880、AKR1D1、MIR4468、TRIM24、SVOPL、ATP6V0A4、TMEM213、KIAA1549、ZC3HAV 1L、ZC3HAV1、TTC26、UBN2、LUC7L2、C7orf55、C7orf55-LUC7L2、PP12708、LOC100129148、KLRG2、CLEC2L、HIPK2、TBXAS1、PARP12、JHDM1D、LOC100134229 、SLC37A3、RAB19、MKRN1、DENND2A、ADCK2、NDUFB2-AS1、NDUFB2、BRAF、MRPS33、TMEM178B、LOC100130169、AGK、KIAA1147、FLJ40852、WEE2、SSBP1、TAS2R 3、TAS2R4、TAS2R5、PRSS37、OR9A4、CLEC5A、TAS2R38、MGAM、LOC93432、MOXD2P、PRSS58、MTRNR2L6、PRSS1、PRSS3P2、EPHB6、TRPV6、TRPV5、C7orf34、KEL、OR9A2、OR6V1、OR6W1P、PIP、TAS2R39、TAS2R40、GSTK1、TMEM139、CASP2、CLCN1、FAM131B、LOC100507507、ZYX、EPHA1、EPHA1-AS1、TAS2R60、TAS2R41、CTAGE15P、FAM115C、 CTAGE6P、LOC154761、FAM115A、OR2F2、OR2F1、OR6B1、OR2A5、OR2A25、OR2A12、OR2A2、OR2A14、CTAGE4、ARHGEF35、OR2A42、OR2A20P、OR2A7、LOC728377、OR2A9P、OR2A1、ARHGEF5、NOBOX、TPK1、CNTNAP2、MIR548F4、LOC100507538、C7orf33、CUL1、EZH2、RNY5、RNY4、RNY3、RNY1、PDIA4、ZNF786、ZNF425、ZNF398、ZNF282、ZNF212、ZNF783、LOC155060、ZNF777、ZNF746、ZNF767、KRBA1、ZNF467、SSPO、ZNF862、ATP6V0E2-AS1、ATP6V0E2、LOC100996256、LOC100134040、ACTR3C、LRRC61、C7orf29、RARRES2、REPIN1、ZNF775、LOC728743、LOC285972、GIMAP8、GIMAP7、GIMAP4、GIMAP6、GIMAP2、GIMAP1、GIMAP1-GIMAP5、GIMAP5、TMEM176B、TMEM176A、ABP1、KCNH2、NOS3、ATG9B、ABCB8、ASIC3、CDK5、SLC4A2、LOC100996677、FASTK、TMUB1、AGAP3、GBX1、ASB10、ABCF2、CHPF2、MIR671、SMARCD3、NUB1、WDR86、WDR86-AS1、CRYGN、MIR3907、RHEB、PRKAG2、LOC644090、PRKAG2-AS1、GALNTL5、GALNT11、MLL3、FABP5P3、LOC100128822、XRCC2、ACTR3B、DPP6、LOC100996700、LOC100132707、PAXIP1、LOC202781、LOC100128264、HTR5A、LOC100996388、INSIG1、EN2、CNPY1、LOC100506302、RBM33、SHH、LOC100996445、LOC389602、LOC285889、LOC100506380、LINC00244、C7orf13、RNF32、LMBR1、NOM1、MNX1、LOC645249、LOC100996426、UBE3C、LOC100506458、DNAJB6、LOC100506534、LOC100506557、PTPRN2、MIR153-2、 LOC100506585、MIR595、MIR5707、NCAPG2、ESYT2、WDR60、LINC00689、VIPR2 、OR4F21、RPL23AP53、ZNF596、FAM87A、FBXO25、C8orf42、LOC100996633、LO C389607、ERICH1、LOC401442、LOC286083、DLGAP2、LOC100507435、CLN8、MI R3674、MIR596、ARHGEF10、LOC100131395、KBTBD11、MYOM2、CSMD1、LOC1002 87015、MCPH1、ANGPT2、LOC100507530、AGPAT5、MIR4659A、MIR4659B、XKR5、 LOC100652791, DEFB1, DEFA6, DEFA4, DEFA10P, DEFA1, DEFT1P, DEFA1B, DEFT1P2, DEFA3, DEFA5, LOC349196, FAM66B, DEFB109P1B, USP17L1P, USP17L4, Z NF705G、DEFB4B、DEFB103B、SPAG11B、DEFB104B、DEFB106B、DEFB105B、DEFB 107B、LOC100131608、FAM90A7P、FAM90A10P、LOC100133251、DEFB107A、DEF B105A、DEFB106A、DEFB104A、SPAG11A、DEFB103A、DEFB4A、ZNF705B、FAM66E 、USP17L8、USP17L3、LOC100132046、MIR548I3、FAM86B3P、SGK223、CLDN23、M FHAS1、ERI1、MIR4660、PPP1R3B、LOC157273、TNKS、MIR597、LINC00599、MIR 124-1、MSRA、PRSS55、RP1L1、MIR4286、C8orf74、SOX7、PINX1、MIR1322、XKR 6, MIR598, MTMR9, SLC35G5, TDH, C8orf12, FAM167A, BLK, LINC00208, GATA4, C8orf49, NEIL2, FDFT1, CTSB, DEFB136, DEFB135, DEFB134, LOC100133267ZNF705D、FAM66D、LOC392196、USP17L7、USP17L2、FAM90A2P、FAM86B1、FAM85A、DEFB130、FAM66A、LOC649352、DEFB109P1、FAM86B2、LOC100506990、LOC729732、MIR5692A2、LONRF1、MIR3926-1、MIR3926-2、LOC340357、KIAA1456、DLC1、C8orf48、SGCZ、MIR383、TUSC3、MSR1、FGF20、EFHA2、ZDHHC2、CNOT7、VPS37A、MTMR7、SLC7A2、PDGFRL、MTUS1、MIR548V、FGL1、PCM1、ASAH1、NAT1、NAT2、PSD3、NSAP11、LOC100128993、SH2D4A、CSGALNACT1、INTS10、LPL、SLC18A1、ATP6V1B2、LZTS1、LZTS1-AS1、LOC286114、GFRA2、DOK2、XPO7、NPM2、FGF17、EPB49、FAM160B2、NUDT18、HR、REEP4、LGI3、SFTPC、BMP1、PHYHIP、MIR320A、POLR3D、LOC100507071、PIWIL2、SLC39A14、PPP3CC、SORBS3、PDLIM2、C8orf58、KIAA1967、BIN3、FLJ14107、EGR3、PEBP4、RHOBTB2、TNFRSF10B、LOC286059、LOC254896、TNFRSF10C、TNFRSF10D、TNFRSF10A、LOC389641、CHMP7、R3HCC1、LOXL2、LOC100507156、ENTPD4、SLC25A37、NKX3-1、NKX2-6、STC1、ADAM28、ADAMDEC1、ADAM7、LOC100507207、NEFM、NEFL、DOCK5、GNRH1、KCTD9、CDCA2、LOC100507222、EBF2、PPP2R2A、BNIP3L、PNMA2、DPYSL2、ADRA1A、MIR548H4、STMN4、TRIM35、PTK2B、CHRNA2、EPHX2、CLU、SCARA3、MIR3622B、MIR3622A、CCDC25、ESCO2、PBK、SCARA5、MIR4287、NUGGC、ELP3、PNOC、ZNF395、FBXO16、FZD3、MIR4288、EXTL3、INTS9、HMBOX1、KIF13B、DUSP4、LINC00589、LOC286135、MIR3148、TMEM66、LEPROTL1、MBOAT4、DCTN6、LOC100128750、RBPMS、GTF2E2、LOC100507341、GSR、UBXN8、PPP2CB、TEX15、PURG、WRN、NRG1、NRG1-IT3、FUT10、MAK16、TTI2、SNORD13、RNF122、DUSP26、UNC5D、KCNU1、LOC100507403、LOC100507420、LOC100507439、ZNF703、ERLIN2、LOC728024、PROSC、GPR124、BRF2、RAB11FIP1、GOT1L1、ADRB3、EIF4EBP1、ASH2L、STAR、LSM1、BAG4、DDHD2、PPAPDC1B、WHSC1L1、LETM2、FGFR1、C8orf86、RNF5P1、TACC1、PLEKHA2、HTRA4、TM2D2、ADAM9、ADAM32、ADAM5、ADAM3A、LOC100130964、ADAM18、ADAM2、IDO1、IDO2、C8orf4、LOC100507481、LOC100996474、ZMAT4、SFRP1、MIR548AO、GOLGA7、GINS4、AGPAT6、NKX6-3、ANK1、MIR486、KAT6A、AP3M2、PLAT、IKBKB、POLB、DKK4、VDAC3、SLC20A2、C8orf40、CHRNB3、CHRNA6、THAP1、RNF170、MIR4469、HOOK3、FNTA、SGK196、HGSNAT、POTEA、LINC00293、LOC100505775、LOC100287846、KIAA0146、CEBPD、PRKDC、MCM4、UBE2V2、EFCAB1、SNAI2、C8orf22、LOC100507464、SNTG1、PXDNL、PCMTD1、LOC100287313、ST18、FAM150A、RB1CC1、NPBWR1、OPRK1、ATP6V1H、RGS20、TCEA1、LYPLA1、MRPL15、RNU105C、SOX17、LOC100129098、RP1、LOC100996304、LOC100287651、XKR4、SBF1P1、TMEM68、TGS1、LYN、RPS20、SNORD54、MOS、PLAG1、CHCHD7、SDR16C5、SDR16C6P、PENK、LOC100507632、IMPAD1、LOC100507651、LOC286177、LINC00588、LOC286178、FAM110B、UBXN2B、CYP7A1、SDCBP、NSMAF、TOX、LOC100505501、CA8、LOC100505532、RAB2A、CHD7、LOC100130298、CLVS1、ASPH、MIR4470、NKAIN3、UG0898H09、GGH、TTPA、YTHDF3、LOC286184、LOC100130155、 MIR124-2、LOC401463、BHLHE22、CYP7B1、LOC100505613、LINC00251、LOC286186、ARMC1、MTFR1、PDE7A、DNAJC5B、TRIM55、CRH、LOC100505659、LOC100505676、RRS1、ADHFE1、C8orf46、MYBL1、VCPIP1、C8orf44-SGK3、C8orf44、SGK3、PTTG3P、MCMDC2、SNHG6、SNORD87、TCF24、PPP1R42、COPS5、CSPP1、ARFGEF1、CPA6、PREX2、LOC286189、C8orf34、LOC100505718、LOC100505739、SULF1、SLCO5A1、PRDM14、NCOA2、TRAM1、LOC286190、LACTB2、XKR9、EYA1、MSC、LOC100132891、TRPA1、LOC392232、KCNB2、LOC100288310、TERF1、SBSPON、LOC100130301、RPL7、RDH10、STAU2-AS1、STAU2、UBE2W、TCEB1、TMEM70、LY96、JPH1、GDAP1、MIR5681A、MIR5681B、FLJ39080、MIR2052、PI15、CRISPLD1、HNF4G、ZFHX4-AS1、ZFHX4、PEX2、PKIA、ZC2HC1A、IL7、STMN2、HEY1、MRPS28、TPD52、MIR5708、ZBTB10、ZNF704、PAG1、FABP5、PMP2、FABP9、FABP4、FABP12、IMPA1、SLC10A5、ZFAND1、CHMP4C、SNX16、RALYL、LRRCC1、E2F5、C8orf59、LOC100507258、CA13、CA1、CA3、LOC100996348、CA2、REXO1L1、REXO1L2P、LOC100288562、PSKH2、ATP6V0D2、SLC7A13、WWP1、FAM82B、CPNE3、CNGB3、CNBD1、DCAF4L2、MMP16、LOC100996398、LOC100506342、RIPK2、OSGIN2、NBN、DECR1、CALB1、LINC00534、TMEM64、LOC100506351、NECAB1、LOC100127983、TMEM55A、LOC100506365、OTUD6B、LRRC69、MIR4661、SLC26A7、RUNX1T1、FLJ46284、TRIQK、C8orf87、LINC00535、FAM92A1、FP6628、RBM12B、RBM12B-AS1、TMEM67、MIR378D2、PDP1、CDH17、GEM、RAD54B、FSBP、KIAA1429、LOC100288748、ESRP1、DPY19L4、INTS8、CCNE2、TP53INP1、LOC100506538、NDUFAF6、LOC286149、MIR3150B、MIR3150A、PLEKHF2、C8orf69、C8orf37、LOC100616530、LOC100500773、GDF6、UQCRB、MTERFD1、PTDSS1、SDC2、CPQ、TSPYL5、MTDH、LAPTM4B、MATN2、LOC100506558、RPL30、SNORA72、C8orf47、HRSP12、POP1、NIPAL2、KCNS2、STK3、OSR2、VPS13B、MIR599、MIR875、COX6C、RGS22、MIR1273A、FBXO43、POLR2K、SPAG1、RNF19A、MIR4471、ANKRD46、SNX31、PABPC1、YWHAZ、FLJ42969、ZNF706、LOC100506652、NACAP1、GRHL2、NCALD、MIR5680、RRM2B、UBR5、ODF1、KLF10、AZIN1、LOC100506753、LOC100996457、ATP6V1C1、C8orf56、BAALC、MIR3151、LOC100499183、FZD6、CTHRC1、SLC25A32、DCAF13、LOC100996462、RIMS2、DCSTAMP、DPYS、LOC100130232、MIR548A3、LRP12、ZFPM2、OXR1、ABRA、ANGPT1、RSPO2、EIF3E、EMC2、TMEM74、TRHR、NUDCD1、ENY2、PKHD1L1、EBAG9、SYBU、KCNV1、CSMD3、MIR2053、TRPS1、LINC00536、EIF3H、UTP23、RAD21、RAD21-AS1、MIR3610、AARD、SLC30A8、MED30、EXT1、SAMD12、SAMD12-AS1、TNFRSF11B、COLEC10、MAL2、NOV、ENPP2、TAF2、DSCC1、DEPTOR、COL14A1、MRPL13、MTBP、SNTB1、HAS2、HAS2-AS1、ZHX2、DERL1、WDR67、FAM83A、LOC100131726、MIR4663、 C8orf76、ZHX1-C8ORF76、ZHX1、ATAD2、MIR548D1、MIR548AA1、WDYHV1、FBXO32、KLHL38、ANXA13、FAM91A1、FER1L6、FER1L6-AS1、TMEM65、TRMT12、LOC100507018、RNF139、TATDN1、NDUFB9、MTSS1、MIR4662B、MIR4662A、LOC157381、ZNF572、SQLE、KIAA0196、NSMCE2、TRIB1、LOC100130231、FAM84B、PCAT1、LOC100507056、POU5F1B、LOC727677、MYC、MIR1204、PVT1、LOC100507101、TMEM75、MIR1205、MIR1206、MIR1207、MIR1208、LOC728724、MIR3686、GSDMC、FAM49B、MIR5194、ASAP1、LOC100507117、ASAP1-IT1、ADCY8、EFR3A、OC90、HHLA1、KCNQ3、HPYR1、LRRC6、TMEM71、PHF20L1、TG、SLA、WISP1、NDRG1、ST3GAL1、LOC100507162、ZFAT、ZFAT-AS1、MIR30B、MIR30D、LOC286094、KHDRBS3、FLJ45872、FAM135B、COL22A1、KCNK9、TRAPPC9、LOC100131910、CHRAC1、EIF2C2、PTK2、MIR151A、DENND3、SLC45A4、LOC731779、GPR20、PTP4A3、FLJ43860、MIR1302-7、MIR4472-1、LINC00051、TSNARE1、BAI1、ARC、JRK、PSCA、LY6K、LOC100288181、THEM6、SLURP1、LYPD2、LYNX1、LY6D、GML、CYP11B1、CYP11B2、LOC100133669、LY6E、C8orf31、LY6H、GPIHBP1、ZFP41、GLI4、LOC100507316、ZNF696、TOP1MT、RHPN1-AS1、RHPN1、MAFA、ZC3H3、GSDMD、C8orf73、NAPRT1、EEF1D、TIGD5、PYCRL、TSTA3、ZNF623、ZNF707、BREA2、CCDC166、MAPK15、FAM83H、MIR4664、LOC100128338、SCRIB、MIR937、PUF60、NRBP2、EPPK1、PLEC、MIR661、PARP10、GRINA、SPATC1、SMPD5、OPLAH、EXOSC4、GPAA1、CYC1、SHARPIN、MAF1、KIAA1875、FAM203A、HEATR7A、SCXB、FAM203B、LOC377711、BOP1、SCXA、HSF1、DGAT1、SCRT1、TMEM249、FBXL6、SLC52A2、ADCK5、CPSF1、MIR939、MIR1234、SLC39A4、VPS28、TONSL、LOC100287098、CYHR1、KIFC2、FOXH1、PPP1R16A、GPT、MFSD3、RECQL4、LRRC14、LRRC24、C8orf82、ARHGAP39、LOC100996662、ZNF251、ZNF34、RPL8、ZNF517、LOC100129596、ZNF7、COMMD5、ZNF250、ZNF16、ZNF252P、TMED10P1、ZNF252P-AS1、C8orf33、DDX11L5、WASH1、MIR1302-9、FAM138C、FOXD4、CBWD1、C9orf66、DOCK8、KANK1、DMRT1、DMRT3、DMRT2、SMARCA2、FLJ35024、VLDLR、KCNV2、KIAA0020、RFX3、DSERG1、GLIS3、GLIS3-AS1、SLC1A1、SPATA6L、PPAPDC2、CDC37L1、AK3、RCL1、MIR101-2、JAK2、INSL6、INSL4、RLN2、RLN1、PLGRKT、CD274、PDCD1LG2、KIAA1432、ERMP1、MLANA、KIAA2026、MIR4665、RANBP6、LOC100506189、IL33、TPD52L3、UHRF2、C9orf38、GLDC、KDM4C、C9orf123、PTPRD、TYRP1、LURAP1L、MPDZ、FLJ41200、LOC100506304、LINC00583、NFIB、ZDHHC21、CER1、FREM1、LOC389705、TTC39B、SNAPC3、PSIP1、CCDC171、RNU6-14、LOC100506331、BNC2、LOC648570、CNTLN、SH3GL2、ADAMTSL1、MIR3152、FAM154A、RRAGA、HAUS6、SCARNA8、PLIN2、DENND4C、RPS6、ACER2、LOC392288、SLC24A2、MLLT3、MIR4473、MIR4474、FOCAD、MIR491、PTPLAD2、 IFNB1、IFNW1、IFNA21、IFNA4、IFNA7、IFNA10、IFNA16、IFNA17、IFNA14、IF NA22P、IFNA5、KLHL9、IFNA6、IFNA13、IFNA2、IFNA8、IFNA1、MIR31HG、IFNE、 MIR31、MTAP、C9orf53、CDKN2A、CDKN2B-AS1、CDKN2B、DMRTA1、FLJ35282、EL AVL2、IZUMO3、TUSC1、LOC100506422、CAAP1、PLAA、IFT74、LRRC19、TEK、LIN C00032、EQTN、MOB3B、IFNK、C9orf72、LINGO2、MIR876、MIR873、LOC401497 、ACO1、DDX58、TOPORS、LOC100129250、NDUFB6、C9orf133、TAF1L、TMEM215、 APTX、DNAJA1、SMU1、B4GALT1、SPINK4、BAG1、CHMP5、NFX1、AQP7、AQP3、NOL6 、SUGT1P1、ANKRD18B、ANXA2P2、PTENP1、PRSS3、UBE2R2、UBAP2、SNORD121B、 SNORD121A、DCAF12、UBAP1、KIF24、NUDT2、KIAA1161、C9orf24、FAM219A、D NAI1、ENHO、CNTFR、LOC415056、RPP25L、DCTN3、ARID3C、SIGMAR1、GALT、IL1 1RA、CCL27、LOC730098、CCL19、CCL21、FAM205A、FAM205B、KIAA1045、DNAJB 5、C9orf131、VCP、FANCG、PIGO、STOML2、FAM214B、UNC13B、LOC100509263、A TP8B5P、RUSC2、FAM166B、TESK1、MIR4667、CD72、SIT1、RMRP、CCDC107、ARHG EF39、CA9、TPM2、TLN1、CREB3、GBA2、RGP1、MSMP、NPR2、SPAG8、HINT2、FAM22 1B、TMEM8B、FP588、OR13J1、HRCT1、LOC158376、OR2S2、RECK、GLIPR2、CCIN、 CLTA、GNE、RNF38、MELK、MIR4475、PAX5、MIR4540、MIR4476、LOC100130458、LOC100506710、ZCCHC7、GRHPR、ZBTB5、POLR1E、FBXO10、TOMM5、FRMPD1、TRMT10B、EXOSC3、DCAF10、SLC25A51、SHB、ALDH1B1、IGFBPL1、FAM220BP、LOC100289137、ANKRD18A、FAM201A、CNTNAP3、SPATA31A1、LOC653501、SPATA31A2、FAM74A1、LOC441402、SPATA31A3、FAM74A3、ZNF658、FAM74A2、SPATA31A4、SPATA31A5、ZNF658B、MGC21881、KGFLP2、ANKRD20A2、FAM95B1、LOC100996667、CBWD7、FOXD4L2、LOC100996312、AQP7P3、ANKRD20A3、LOC642929、SPATA31A6、CNTNAP3B、LOC100505781、FAM27C、FAM27E4P、FAM27A、FAM27E2、LOC100287368、LOC100507284、FAM27E1、FAM27D1、LOC100996612、KGFLP1、LOC64364...

Claims

1. 1. A method for quality control of cells for the treatment of meniscus injury, comprising: Controlling the behavior of one or more specific protein molecules that are essential for the expression of a therapeutic effect by cells; Managing the expression behavior of related genes characteristic of the cells; and the specific protein molecule is one or more of CD29, CD140b, and Col2A1 (collagen, type II, alpha 1); the group of related genes characteristic of the cell is composed of 50 to 2000 genes, the related gene group characteristic of the cells is selected from at least one of an immune-related gene group, an inflammation-related gene group, an angiogenesis-related gene group, a nerve regeneration-related gene group, a chondrogenesis-related gene group, a osteogenesis-related gene group, an adipogenesis-related gene group, a fibrosis-related gene group, an immunogenicity-related gene group, a migration-related gene group, an adhesion-related gene group, an aging-related gene group, a mesenchymal stem cell marker-related gene group, a surface marker-related gene group, a growth factor-related gene group, and a chemokine- or cytokine-related gene group; In managing the expression behavior of the related gene group characteristic of the cell, when a correlation between an expression pattern of the gene group obtained by measuring the expression state of the related gene group characteristic of the cell and a reference expression pattern is equal to or greater than a certain level, the cell is determined to be usable; The case where the correlation is equal to or greater than a certain level is when the correlation coefficient or the coefficient of determination, or the correlation coefficient and the coefficient of determination, are evaluated and the correlation coefficient or the coefficient of determination is equal to or greater than a certain level, The cell is at least one type of cell selected from the group consisting of somatic stem cells, induced pluripotent stem cells, embryonic stem cells, differentiated cells derived from somatic stem cells, differentiated cells derived from induced pluripotent stem cells, and differentiated cells derived from embryonic stem cells. method.

2. When evaluating the correlation coefficient or the coefficient of determination, (i) Substitute missing values ​​for which the expression level of a gene cannot be measured with the lower limit of measurement; (ii) replacing missing values ​​for which gene expression levels cannot be measured with the lowest measured value, or (iii) processing missing values ​​for which gene expression levels cannot be measured using the following formula: read count for each gene + (1 × gene length / average gene length); The correlation coefficient or the coefficient of determination is calculated by performing any one of the following: The method of claim 1.

3. The method according to claim 1 or 2, wherein the behavior of the specific protein molecule is an expression level.

4. The method of claim 1 , wherein the cells are mesenchymal stem cells.

5. Selecting cells that meet the criteria from a cell population that includes candidate cells for treating meniscus injury by the method of any one of claims 1 to 4; and Expanding the selected cells ex vivo A method for producing cells for treating meniscus injury, comprising:

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