Methods and Compositions for Neuroprotection

Abstract

To provide compositions and methods for treating neurodegeneration and neurodegenerative diseases associated with axonal degeneration.SOLUTION: The present invention provides an antisense oligonucleotide comprising a sequence having at least 90% identity to a sequence selected from the group consisting of specific sequences, which is complementary to a target region of a nucleic acid encoding Sterile Alpha and TIR motif-containing 1 (SARM1), and a pharmaceutical composition comprising the antisense oligonucleotide and a pharmaceutically acceptable diluent or carrier.SELECTED DRAWING: None

Description

[Technical Field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of U.S. Provisional Patent Application No. 62 / 940,437, filed November 26, 2019, which is incorporated herein by reference in its entirety.

[0002] Sequence Listing This application contains a Sequence Listing that has been submitted electronically in ASCII format and is incorporated by reference herein in its entirety. The ASCII copy created on November 23, 2020 is named 2012800-0042_SL.txt and is 652,394 bytes in size. [Background technology]

[0003] Axonal degeneration is a hallmark of several neurological disorders, including peripheral neuropathy, traumatic brain injury, and neurodegenerative diseases (Gerdts et al., Science, 2015, 348:453-457, incorporated herein by reference in its entirety). Neurodegenerative diseases and injuries are devastating to both patients and caregivers. The costs associated with these diseases currently exceed hundreds of billions of dollars annually in the United States alone. Because the incidence of many of these diseases and disorders increases with age, their incidence is rapidly increasing with demographic changes. Summary of the Invention [Means for solving the problem]

[0004] The present invention is based, at least in part, on the insight that following axonal injury, Sterile Alpha and TIR motif-containing 1 (SARM1) functions as a central cleavage executive in the axon degeneration pathway. The present invention provides, inter alia, the recognition that antisense oligonucleotides that inhibit SARM1 are particularly useful for preventing axon degeneration.

[0005] In one aspect, the disclosure provides an antisense oligonucleotide comprising a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3-2412.

[0006] In some embodiments, the antisense oligonucleotide comprises one or more modifications. In some embodiments, the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof.

[0007] In another aspect, the present disclosure includes pharmaceutical compositions comprising the antisense oligonucleotides of the present disclosure. In some embodiments, the pharmaceutical composition comprises a pharmaceutically acceptable carrier.

[0008] In another aspect, the present disclosure includes a method for treating and / or preventing axonal degeneration in a subject, comprising administering to the subject an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1).

[0009] In another aspect, the disclosure includes a method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1.

[0010] In some embodiments, the target nucleic acid encoding SARM1 is SARM1 mRNA.

[0011] In some embodiments, the antisense oligonucleotide comprises a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3-2412.

[0012] In some embodiments, the antisense oligonucleotide comprises one or more modifications. In some embodiments, the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof.

[0013] In some embodiments, administering the antisense oligonucleotide reduces the level of SARM1 mRNA in the subject. In some embodiments, administering the antisense oligonucleotide reduces the level of SARM1 protein in the subject.

[0014] In some embodiments, the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration.

[0015] In some embodiments, the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. In some embodiments, the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. In some embodiments, the chronic disease or disorder of the PNS comprises a hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. In some embodiments, the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiencies, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. In some embodiments, the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, ligament rupture, or diabetes. In some embodiments, the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, liver failure, polycythemia, amyloidosis, acromegaly, porphyria, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiency, vitamin deficiency, or mitochondrial disorder.

[0016] In some embodiments, the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. In some embodiments, the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or chemical or chemotherapeutic injury. In some embodiments, the mechanical injury comprises a compressive or constriction injury or pressure injury. In some embodiments, the compressive or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. In some embodiments, the pressure injury comprises pressure involving the superficial peroneal nerve, pressure due to a tumor, or elevated intraocular pressure. In some embodiments, the chemical or chemotherapeutic agent comprises a cytotoxic anticancer agent, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based agent, or auristatin. In some embodiments, the epothilone is ixabepilone. In some embodiments, the taxane is paclitaxel or docetaxel. In some embodiments, the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. In some embodiments, the proteasome inhibitor is bortezomib. In some embodiments, the platinum-based drug is cisplatin, oxaliplatin, or carboplatin. In some embodiments, the auristatin is conjugated monomethyl auristatin E.

[0017] In some embodiments, the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. In some embodiments, the chronic disease or disorder of the CNS comprises Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukoencephalopathy, and the like. neuropathy, including neuromalacia, hereditary ataxia, noise-induced hearing loss, congenital hearing loss, age-related hearing loss, Creutzfeldt-Jakob disease, transmissible spongiform encephalopathy, dementia with Lewy bodies, frontotemporal dementia, amyloidosis, diabetic neuropathy, globoid cell leukodystrophy (Krabbe disease), Bassen-Kornzweig syndrome, transverse myelitis, motor neuron disease, spinocerebellar ataxia, pre-eclampsia, hereditary spastic paraplegia, spastic paraplegia, familial spastic paraplegia, French colonial disease, Strampel-Lorraine disease, non-alcoholic steatohepatitis (NASH), adrenomyeloneuropathy, progressive supranuclear palsy (PSP), Friedreich's ataxia, or spinal cord injury.

[0018] In some embodiments, the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or metabolic disease or disorder. In some embodiments, the optic neuropathy comprises acute optic neuropathy (AON), hereditary or idiopathic retinal conditions, Leber congenital amaurosis (LCA), Leber hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedziehl's optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. In some embodiments, the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). In some embodiments, the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, liver failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders.

[0019] In some embodiments, the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. In some embodiments, the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. In some embodiments, ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. In some embodiments, the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush, or thin axons. In some embodiments, the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). In some embodiments, the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes.

[0020] In some embodiments, the subject is a human. In some embodiments, the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. In some embodiments, the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. In some embodiments, the one or more genetic risk factors for neurodegeneration include one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. In some embodiments, engaging in one or more high-risk activities comprises participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, or windsurfing.In some embodiments, the one or more biomarkers of neurodegeneration include: a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; is the constitutive cADPR level in axons; the levels of albumin, amyloid-β (Aβ) 38, Aβ 40, Aβ 42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP) α, sAPP β, soluble triggering receptor expressed on myeloid cells (sTREM) 2, phospho-tau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and CC in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. levels of Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF)1, or interleukin (IL)6; [Brief explanation of the drawings]

[0021] The foregoing and other features and advantages of the present invention will be more fully understood from the following detailed description of illustrative embodiments taken in conjunction with the accompanying drawings, it being understood that the invention is not limited to the precise arrangements and instrumentalities of the embodiments shown in the drawings.

[0022] [Figure 1] A map of an antisense oligonucleotide complementary to human SARM1 mRNA is shown. [Figure 2] 1 shows a graph depicting the average fold change in SARM1 gene expression in cells after transfection with SARM1 antisense oligonucleotides. [Figure 3] 1 shows a graph depicting the average fold change in SARM1 gene expression in cells after transfection with SARM1 antisense oligonucleotides. [Figure 4] 1 shows a graph depicting relative SARM1 mRNA expression in human induced pluripotent stem cell (IPSC)-derived motor neurons after transfection with antisense oligonucleotides targeting the SARM1 transcript. [Figure 5] 1 shows a graph depicting relative SARM1 mRNA expression in human induced pluripotent stem cell (IPSC)-derived motor neurons after delivery by free uptake (i.e., in the absence of a lipid carrier) with an antisense oligonucleotide targeting the SARM1 transcript. [Figure 6] 1 shows a graph showing relative SARM1 mRNA expression in human induced pluripotent stem cell (IPSC)-derived motor neurons 2 and 6 days after delivery by free uptake (i.e., in the absence of a lipid carrier) with an antisense oligonucleotide targeting the SARM1 transcript. [Figure 7] 1 shows a graph showing that SARM1 antisense oligonucleotides prevent axonal degeneration after axotomy in human iPSC-derived motor neurons treated using free uptake delivery.

[0023] definition Binding: As used herein, the term "binding" is typically understood to refer to an association (e.g., non-covalent or covalent) between or among two or more entities. "Direct" binding includes physical contact between the entities or moieties, while indirect binding includes physical interaction through physical contact with one or more intermediate entities. Binding between two or more entities can typically be assessed in any of a variety of contexts, including when the interacting entities or moieties are studied in isolation or in the context of a more complex system (e.g., in covalent or other association with a carrier entity, and / or in a biological system or cell).

[0024] Biological sample: As used herein, the term "biological sample" typically refers to a sample obtained or derived from a biological source of interest (e.g., a tissue or organism or cell culture), as described herein. In some embodiments, the source of interest includes an organism, such as an animal or a human. In some embodiments, the biological sample is or includes a biological tissue or fluid. In some embodiments, the biological sample can be or include bone marrow, blood, blood cells, ascites, tissue or fine needle biopsy sample, cell-containing body fluid, suspended nucleic acid, sputum, saliva, urine, cerebrospinal fluid, peritoneal fluid, pleural effusion, feces, lymph, gynecological fluid, skin swab, vaginal swab, oral swab, nasal swab, lavage or perfusion such as ductal irrigation or bronchoalveolar irrigation, aspirate, scraping, bone marrow specimen, tissue biopsy specimen, surgical specimen, other body fluid, secretion, and / or excretion, and / or cells therefrom, etc. In some embodiments, a biological sample is or comprises cells obtained from an individual. In some embodiments, the obtained cells are or comprise cells from the individual from whom the sample is obtained. In some embodiments, a sample is a "primary sample" obtained directly from a source of interest by any suitable means. For example, in some embodiments, a primary biological sample is obtained by a method selected from the group consisting of biopsy (e.g., fine needle aspiration or tissue biopsy), surgery, collection of bodily fluids (e.g., blood, lymph, feces, etc.), and the like. In some embodiments, as is clear from the context, the term "sample" refers to a preparation obtained by processing a primary sample (e.g., by removing one or more components and / or adding one or more agents), such as filtering using a semipermeable membrane. Such a "processed sample" can include, for example, nucleic acids or proteins extracted from the sample or obtained by subjecting the primary sample to techniques such as amplification or reverse transcription of mRNA, isolation and / or purification of specific components, etc.

[0025] Biomarker: The term "biomarker" is used herein to refer to an entity, event, or characteristic whose presence, level, degree, type, and / or form correlates with a particular biological event or condition of interest, and is therefore considered a "marker" for that event or condition. To name just a few, in some embodiments, a biomarker can be or include a marker for a particular disease state or the likelihood of a particular disease, disorder, or condition developing, occurring, or recurring. In some embodiments, a biomarker can be or include a marker for a particular disease or treatment outcome, or the likelihood thereof. Thus, in some embodiments, a biomarker is predictive, in some embodiments, a biomarker is prognostic, and in some embodiments, a biomarker is diagnostic for the relevant biological event or condition of interest. A biomarker can be or include any chemical class of entity, and can be or include a combination of entities. For example, in some embodiments, a biomarker can be or include a nucleic acid, a polypeptide, a lipid, a carbohydrate, a small molecule, an inorganic substance (e.g., a metal or ion), or a combination thereof. In some embodiments, the biomarker is a cell surface marker. In some embodiments, the biomarker is intracellular. In some embodiments, the biomarker is detected outside the cell (e.g., secreted or otherwise produced or present outside the cell in bodily fluids, such as, for example, blood, urine, tears, saliva, cerebrospinal fluid, etc.). In some embodiments, the biomarker may be or include a genetic or epigenetic signature. In some embodiments, the biomarker may be or include a gene expression signature.

[0026] In some embodiments, the biomarker may be or include a marker for neurodegeneration or the likelihood of onset, occurrence, or recurrence of a neurodegenerative disease, disorder, or condition. In some embodiments, the biomarker may be or include a marker for neurodegenerative treatment outcome or likelihood thereof. Thus, in some embodiments, the biomarker is predictive, in some embodiments, the biomarker is prognostic, and in some embodiments, the biomarker is diagnostic for a neurodegenerative disease, disorder, or condition. In some embodiments, changes in biomarker levels can be detected via cerebrospinal fluid (CSF), plasma, and / or serum. In some embodiments, the biomarker can be a detectable signal generated by medical imaging techniques, including, but not limited to, magnetic resonance imaging (MRI), positron emission tomography (PET), and / or computed tomography (CT). In some embodiments, the biomarker can be a detectable change in electrophysiological properties.

[0027] In some embodiments, neurodegeneration can be assessed by detecting increases and / or decreases in the concentrations of neurofilament light chain protein (NF-L) and / or neurofilament heavy chain protein (NF-H) contained in bodily fluids from a subject, including, but not limited to, cerebrospinal fluid, blood, serum, and / or plasma. In some embodiments, the incidence and / or progression of neurodegeneration can be assessed via positron emission tomography (PET) using synaptic vesicle glycoprotein 2a (SV2A) ligand. In some embodiments, detectable changes in constitutive NAD+ and / or cADPR levels in neurons can be used to assess neurodegeneration.

[0028] In some embodiments, detectable changes in one or more neurodegeneration-associated proteins in a subject compared to a healthy reference population can be used as biomarkers of neurodegeneration. Such proteins include, but are not limited to, albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid-binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phospho-tau, and / or total tau. In some embodiments, increases in cytokines and / or chemokines, including, but not limited to, Ccl2, Ccl7, Ccl12, Csf1, and / or Il6, can be used as biomarkers of neurodegeneration.

[0029] Carrier: As used herein, the term "carrier" refers to a diluent, adjuvant, excipient, or vehicle with which a composition is administered. In some exemplary embodiments, the carrier can comprise sterile liquids, such as water and oils, including those of petroleum, animal, vegetable, or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil, and the like. In some embodiments, the carrier is or comprises one or more solid ingredients.

[0030] Combination: As used herein, the term "combination therapy" or "in combination" refers to a situation in which two or more different pharmaceutical agents for the treatment of a disease are administered in overlapping regimens, resulting in a subject being exposed to at least two agents simultaneously. In some embodiments, the different agents are administered simultaneously. In some embodiments, the administration of one agent overlaps with the administration of at least one other agent. In some embodiments, the different agents are administered sequentially such that the agents have simultaneous biological activity in the subject (e.g., all "doses" of a first regimen are administered before any dose of a second regimen). In some embodiments, "administration" of a combination therapy can include administration of one or more agents or modalities to a subject receiving the other agent or modality in combination. For clarity, combination therapy does not require that the individual agents be administered together in a single composition (or even necessarily simultaneously), although in some embodiments, two or more agents, or active portions thereof, can be administered together in a combination composition or even in a combination compound (e.g., as part of a single chemical complex or covalent conjugate).

[0031] Composition: Those skilled in the art will understand that the term "composition" can be used to refer to a discrete physical entity that includes one or more specific components. Generally, unless otherwise specified, a composition can be in any form—e.g., gas, gel, liquid, solid, etc.

[0032] Domain: As used herein, the term "domain" refers to a section or portion of an entity. In some embodiments, a "domain" is associated with a particular structural and / or functional property of an entity, such that when the domain is physically separated from the remainder of its parent entity, it retains the particular structural and / or functional property intact. Alternatively or additionally, a domain may be a part of or comprise an entity that, when separated from its (parent) entity and combined with a different (recipient) entity, substantially maintains and / or confers to the recipient entity one or more structural and / or functional properties that characterize it in the parent entity. In some embodiments, a domain is a section or portion of a molecule (e.g., a small molecule, carbohydrate, lipid, nucleic acid, or polypeptide). In some embodiments, a domain is a section of a polypeptide, and in some such embodiments, a domain is characterized by particular structural elements (e.g., particular amino acid sequences or sequence motifs, αα helical properties, ββ sheet properties, coiled-coil properties, random coil properties, etc.), and / or particular functional properties (e.g., binding activity, enzymatic activity, folding activity, signaling activity, etc.).

[0033] Dosage form or unit dosage form: Those of skill in the art will understand that the term "dosage form" can be used to refer to a physically discrete unit of an active agent (e.g., a therapeutic or diagnostic agent) for administration to a subject. Typically, each such unit contains a predetermined amount of active agent. In some embodiments, such amount is a unit dosage (or a whole fraction thereof) appropriate for administration according to a dosing regimen (i.e., a therapeutic dosing regimen) that has been determined to correlate with a desirable or beneficial outcome when administered to a relevant population. Those of skill in the art will understand that the total amount of a therapeutic composition or agent to be administered to a particular subject is determined by one or more attending physicians and may include the administration of multiple dosage forms.

[0034] Dosing regimen or treatment regimen: Those skilled in the art will understand that the terms "dosing regimen" and "treatment regimen" can be used to refer to a series of unit doses (typically more than one) administered individually to a subject, typically separated by a period of time. In some embodiments, a given therapeutic agent has a recommended dosing regimen, which can include one or more doses. In some embodiments, a dosing regimen includes multiple doses, each separated in time from the other doses. In some embodiments, the individual doses are separated from each other by periods of equal length, and in some embodiments, a dosing regimen includes multiple doses and at least two different periods separating the individual doses. In some embodiments, all doses within a dosing regimen are the same unit dose amount. In some embodiments, different doses within a dosing regimen are different amounts. In some embodiments, a dosing regimen includes a first dose in a first dose amount, followed by one or more additional doses in a second dose amount that is different from the amount of the first dose. In some embodiments, the dosing regimen includes a first dose in a first dose amount, followed by one or more additional doses in a second dose amount that is the same as the first dose amount. In some embodiments, the dosing regimen is correlated with a desired or beneficial outcome when administered across a relevant population (i.e., is a therapeutic dosing regimen).

[0035] Excipient: As used herein, refers to a non-therapeutic agent that may be included in a pharmaceutical composition, for example, to provide or contribute to a desired consistency or stabilizing effect. Suitable pharmaceutical excipients include, for example, starch, glucose, lactose, sucrose, gelatin, malt, rice, wheat flour, chalk, silica gel, sodium stearate, glycerol monostearate, talc, sodium chloride, dried skim milk, glycerol, propylene, glycol, water, ethanol, etc.

[0036] Inhibitor: As used herein, the term "inhibitor" refers to an entity, condition, or event whose presence, level, or extent correlates with a decrease in the level or activity of a target. In some embodiments, an inhibitor can act directly (in which case it exerts its effect directly on the target, e.g., by binding to the target), while in some embodiments, an inhibitor can act indirectly (in which case it exerts its effect by interacting with and / or otherwise altering a regulator of the target, resulting in a decrease in the target level and / or activity). In some embodiments, an inhibitor is one whose presence or level correlates with a decrease in the target level or activity compared to a particular reference level or activity (e.g., observed under appropriate reference conditions, such as the presence of a known inhibitor or the absence of the inhibitor in question).

[0037] Neurodegeneration: As used herein, the term "neurodegeneration" refers to a decrease in one or more properties, structure, function, or characteristics of neurons or nervous tissue. In some embodiments, neurodegeneration is observed as a pathological decrease in an organism. Those skilled in the art will understand that neurodegeneration is associated with certain diseases, disorders, and conditions, including those that affect humans. In some embodiments, neurodegeneration can be transient (e.g., occurring sometimes in association with certain infections and / or chemical or mechanical disruption), while in some embodiments, neurodegeneration can be chronic and / or progressive (e.g., often associated with certain diseases, disorders, or conditions, such as, but not limited to, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, or Alzheimer's disease). In some embodiments, neurodegeneration can be assessed, for example, by detecting an increase in a biomarker associated with neurodegeneration in a subject. In some embodiments, neurodegeneration can be assessed, for example, by detecting a decrease in a biomarker associated with neurodegeneration in a subject. Alternatively or additionally, in some embodiments, neurodegeneration can be assessed by magnetic resonance imaging (MRI), biomarkers contained in cerebrospinal fluid, or other biomarkers observed in subjects. In some embodiments, neurodegeneration is defined as a score of less than 24 on the Mini-Mental State Examination. In some embodiments, neurodegeneration refers to synaptic loss. In some embodiments, neurodegeneration refers to the loss of nervous tissue associated with traumatic injury (e.g., exposure to external forces that disrupt the integrity of nervous tissue). In some embodiments, neurodegeneration refers to the loss of peripheral nervous tissue. In some embodiments, neurodegeneration refers to the loss of central nervous tissue.

[0038] Nucleic acid: As used herein, in its broadest sense, refers to any compound and / or substance that is or can be incorporated into an oligonucleotide chain. In some embodiments, nucleic acids are compounds and / or substances that are or can be incorporated into an oligonucleotide chain via phosphodiester bonds. As the context will dictate, in some embodiments, "nucleic acid" refers to individual nucleic acid residues (e.g., nucleotides and / or nucleosides). In some embodiments, "nucleic acid" refers to an oligonucleotide chain comprising individual nucleic acid residues. In some embodiments, "nucleic acid" is or comprises RNA. In some embodiments, "nucleic acid" is or comprises DNA. In some embodiments, a nucleic acid is, comprises, or consists of one or more naturally occurring nucleic acid residues. In some embodiments, a nucleic acid is, comprises, or consists of one or more nucleic acid analogs. In some embodiments, a nucleic acid analog differs from a nucleic acid in that it does not utilize a phosphodiester backbone. For example, in some embodiments, a nucleic acid is, comprises, or consists of one or more "peptide nucleic acids," which are known in the art and have peptide bonds instead of phosphodiester bonds in the backbone and are considered within the scope of the present invention. Alternatively or additionally, in some embodiments, the nucleic acid has one or more phosphorothioate and / or 5'-N-phosphoramidite linkages rather than phosphodiester linkages. In some embodiments, the nucleic acid is, comprises, or consists of one or more naturally occurring nucleosides (e.g., adenosine, thymidine, guanosine, cytidine, uridine, deoxyadenosine, deoxythymidine, deoxyguanosine, and deoxycytidine).In some embodiments, the nucleic acid is, comprises, or consists of one or more nucleoside analogs (e.g., 2-aminoadenosine, 2-thiothymidine, inosine, pyrrolo-pyrimidine, 3-methyladenosine, 5-methylcytidine, C-5 propynyl-cytidine, C-5 propynyl-uridine, 2-aminoadenosine, C5-bromouridine, C5-fluorouridine, C5-iodouridine, C5-propynyl-uridine, C5-propynyl-cytidine, C5-methylcytidine, 2-aminoadenosine, 7-deazaadenosine, 7-deazaguanosine, 8-oxoadenosine, 8-oxoguanosine, O(6)-methylguanine, 2-thiocytidine, methylated bases, inserted bases, and combinations thereof). In some embodiments, the nucleic acid comprises one or more modified sugars (e.g., 2'-fluororibose, ribose, 2'-deoxyribose, arabinose, and hexose) compared to those in naturally occurring nucleic acids. In some embodiments, the nucleic acid has a nucleotide sequence that encodes a functional gene product such as RNA or a protein. In some embodiments, the nucleic acid comprises one or more introns. In some embodiments, the nucleic acid is prepared by one or more of isolation from a natural source, enzymatic synthesis by polymerization based on a complementary template (in vivo or in vitro), replication in a recombinant cell or system, and chemical synthesis. In some embodiments, the nucleic acid is at least 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 20, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 600, 700, 800, 900, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000 or more residues in length. In some embodiments, the nucleic acid is partially or entirely single-stranded. In some embodiments, the nucleic acid is partially or entirely double-stranded.In some embodiments, the nucleic acid has a nucleotide sequence that includes at least one element that encodes or is a complement of a sequence that encodes a polypeptide. In some embodiments, the nucleic acid has enzymatic activity. In some embodiments, the nucleic acid comprises a small interfering RNA (siRNA), a short hairpin RNA (shRNA), an antisense oligonucleotide, a microRNA, a gapmer, or an aptamer.

[0039] Oral: As used herein, the phrases "oral administration" and "administered orally" have their art-understood meaning to refer to administration of a compound or composition by mouth.

[0040] Parenteral: As used herein, the phrases "parenteral administration" and "administered parenterally" have their art-understood meaning to refer to modes of administration other than enteral and topical administration, usually by injection, and include, but are not limited to, intravenous, intramuscular, intraarterial, intrathecal, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal, and intrasternal injection and infusion.

[0041] Patient: As used herein, the term "patient" refers to any organism to which provided compositions are or can be administered, e.g., for experimental, diagnostic, prophylactic, cosmetic, and / or therapeutic purposes. Typical patients include animals (e.g., mammals such as mice, rats, rabbits, non-human primates, and / or humans). In some embodiments, the patient is human. In some embodiments, the patient is suffering from or susceptible to one or more disorders or conditions. In some embodiments, the patient exhibits one or more symptoms of a disorder or condition. In some embodiments, the patient has been diagnosed with one or more disorders or conditions. In some embodiments, the patient is undergoing or has undergone a particular therapy to diagnose and / or treat a disease, disorder, or condition.

[0042] Pharmaceutical composition: As used herein, the term "pharmaceutical composition" refers to an active agent formulated with one or more pharmaceutically acceptable carriers. In some embodiments, the active agent is present in a unit dose amount suitable for administration in a treatment or dosing regimen that exhibits a statistically significant probability of achieving a predetermined therapeutic effect when administered to a relevant population. In some embodiments, the pharmaceutical composition can be specifically formulated in solid or liquid form for administration, including oral administration, e.g., drenches (aqueous or non-aqueous solutions or suspensions), tablets, e.g., buccal, sublingual, and those targeted for systemic absorption, boluses, powders, granules, pastes for application to the tongue, etc.; parenteral administration, e.g., by subcutaneous, intramuscular, intravenous, or epidural injection, e.g., sterile solutions or suspensions, or sustained-release formulations; topical application, e.g., creams, ointments, or sustained-release patches or sprays applied to the skin, lungs, or oral cavity; vaginal or rectal administration, e.g., pessaries, creams, or foams; sublingually, ophthalmically, transdermally, or those adapted for the nose, lungs, and other mucosal surfaces.

[0043] Pharmaceutically acceptable: The term "pharmaceutically acceptable" refers to those compounds, materials, compositions, and / or dosage forms that are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit-risk ratio.

[0044] Pharmaceutically acceptable carrier: As used herein, the term "pharmaceutically acceptable carrier" means a pharmaceutically acceptable material, composition, or vehicle, such as a liquid or solid filler, diluent, excipient, or solvent encapsulating material, that is involved in carrying or transporting a compound of interest from one organ or part of the body to another. Each carrier must be "acceptable" in the sense of being compatible with the other ingredients of the formulation and not harmful to the patient. Some examples of materials that can serve as pharmaceutically acceptable carriers include sugars such as lactose, glucose, and sucrose; starches such as corn starch and potato starch; cellulose and its derivatives such as sodium carboxymethylcellulose, ethyl cellulose, cellulose acetate, and the like; excipients such as powdered tragacanth, malt, gelatin, talc, cocoa butter, and suppository wax; oils such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil, and soybean oil; glycols such as propylene glycol; polyols such as glycerin, sorbitol, mannitol, and polyethylene glycol; esters such as ethyl oleate and ethyl laurate; agar, buffers such as magnesium hydroxide and aluminum hydroxide; alginic acid, pyrogen-free water, isotonic saline, Ringer's solution, ethyl alcohol, pH buffered solutions, polyesters, polycarbonates, and / or polyanhydrides, and other non-toxic, compatible substances used in pharmaceutical formulations.

[0045] Pharmaceutically acceptable salts: As used herein, the term "pharmaceutically acceptable salts" refers to salts of such compounds that are suitable for use in pharmaceutical contexts, i.e., salts that, within the scope of sound medical judgment, are suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response, or other problems or complications, and that are commensurate with a reasonable risk-to-benefit ratio. Pharmaceutically acceptable salts are well known in the art. For example, S. M. Berge et al. describe pharmaceutically acceptable salts in detail in J. Pharmaceutical Sciences, 66:1-19 (1977). In some embodiments, pharmaceutically acceptable salts include, but are not limited to, non-toxic acid addition salts of amino groups formed with inorganic acids such as hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid, and perchloric acid, or organic acids such as acetic acid, maleic acid, tartaric acid, citric acid, succinic acid, or malonic acid, or by using other methods used in the art, such as ion exchange. In some embodiments, pharmaceutically acceptable salts include adipate, alginate, ascorbate, aspartate, benzenesulfonate, benzoate, bisulfate, borate, butyrate, camphorate, camphorsulfonate, citrate, cyclopentanepropionate, digluconate, dodecyl sulfate, ethanesulfonate, formate, fumarate, glucoheptonate, glycerophosphate, gluconate, hemisulfate, heptanoate, hexanoate, hydroiodide, 2-hydroxyethanesulfonate, lanthanide ... Representative alkali or alkaline earth metal salts include, but are not limited to, sodium, lithium, potassium, calcium, magnesium, etc. Representative alkali or alkaline earth metal salts include, but are not limited to, acetobionate, lactate, laurate, lauryl sulfate, malate, maleate, malonate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, oleate, oxalate, palmitate, pamoate, pectinate, persulfate, 3-phenylpropionate, phosphate, picrate, pivalate, propionate, stearate, succinate, sulfate, tartrate, thiocyanate, p-toluenesulfonate, undecanoate, and valerate.In some embodiments, pharmaceutically acceptable salts include non-toxic ammonium, quaternary ammonium, and amine cations formed using counterions such as halides, hydroxides, carboxylates, sulfates, phosphates, nitrates, alkyls having 1 to 6 carbon atoms, sulfonates, and aryl sulfonates, as appropriate.

[0046] Prevent or Prevention: As used herein, the terms "prevent" or "prevention," when used in reference to the occurrence of a disease, disorder, and / or condition, refer to reducing the risk of developing the disease, disorder, and / or condition and / or delaying the onset of one or more characteristics or symptoms of the disease, disorder, or condition. Prevention may be considered complete when the onset of the disease, disorder, or condition has been delayed for a predetermined period of time.

[0047] Specific: The term "specific," as used herein with respect to an active agent, is understood by those skilled in the art to mean that the agent discriminates between potential target entities or conditions. For example, in some embodiments, an agent is said to "specifically" bind to a target if it preferentially binds to that target in the presence of one or more competing surrogate targets. In many embodiments, the specific interaction depends on the presence of particular structural features of the target entity (e.g., epitopes, clefts, binding sites). It should be understood that specificity need not be absolute. In some embodiments, specificity can be assessed relative to that of a binding agent for one or more other potential target entities (e.g., competitors). In some embodiments, specificity is assessed relative to that of a reference specific binding agent. In some embodiments, specificity is assessed relative to that of a reference nonspecific binding agent. In some embodiments, an agent or entity does not detectably bind to a competing surrogate target under conditions that bind to the target entity. In some embodiments, a binding agent binds to the target entity with a higher on-rate, a lower off-rate, an increased affinity, a decreased dissociation, and / or an increased stability relative to the competing surrogate target.

[0048] Subject: As used herein, the term "subject" refers to an organism, typically a mammal (e.g., a human, including in some embodiments prenatal human forms). In some embodiments, the subject is afflicted with the relevant disease, disorder, or condition. In some embodiments, the subject is susceptible to the disease, disorder, or condition. In some embodiments, the subject exhibits one or more symptoms or characteristics of the disease, disorder, or condition. In some embodiments, the subject does not exhibit any symptoms or characteristics of the disease, disorder, or condition. In some embodiments, the subject possesses one or more characteristics characteristic of susceptibility to or risk for the disease, disorder, or condition. In some embodiments, the subject is a patient. In some embodiments, the subject is an individual for whom diagnosis and / or therapy is being and / or is being administered.

[0049] Therapeutic Agent: As used herein, the phrase "therapeutic agent" generally refers to any agent that induces a desired pharmacological effect when administered to an organism. In some embodiments, an agent is considered to be therapeutic if it exhibits a statistically significant effect across an appropriate population. In some embodiments, the appropriate population may be a population of model organisms. In some embodiments, the appropriate population may be defined by various criteria, such as a particular age group, sex, genetic background, pre-existing clinical conditions, etc. In some embodiments, a therapeutic agent is a substance that can be used to alleviate, ameliorate, reduce, inhibit, prevent, delay the onset of, reduce the severity of, and / or reduce the incidence of one or more symptoms or characteristics of a disease, disorder, and / or condition. In some embodiments, a "therapeutic agent" is a drug that has been, or needs to be, approved by a government agency before it can be sold for administration to humans. In some embodiments, a "therapeutic agent" is a drug that requires a prescription for administration to humans.

[0050] Treat: As used herein, the terms "treat," "treatment," or "treating" refer to any method used to partially or completely alleviate, ameliorate, relieve, inhibit, prevent, delay the onset of, reduce the severity of, and / or reduce the incidence of one or more symptoms or characteristics of a disease, disorder, and / or condition. A treatment may be administered to a subject who does not show signs of a disease, disorder, and / or condition. In some embodiments, a treatment may be administered to a subject who shows only early signs of a disease, disorder, and / or condition, for example, for the purpose of reducing the risk of developing a condition associated with the disease, disorder, and / or condition. In some embodiments, a treatment may be administered to a subject to prevent the risk of developing a condition associated with or resulting from a medical procedure and / or treatment. DETAILED DESCRIPTION OF THE INVENTION

[0051] Axonal degeneration and SARM1 The present invention can be used to treat subjects suffering from or susceptible to axonal degeneration. Axonal degeneration is a key pathological characteristic of neurological diseases, including, but not limited to, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis, diabetic peripheral neuropathy, chemotherapy-induced peripheral neuropathy, hereditary neuropathy, traumatic brain injury, and / or glaucoma. Damaged or unhealthy axons are eliminated by an intrinsic self-destruction program known as Wallerian degeneration, which is distinct from conventional cell death pathways such as apoptosis (Gerdts, J., et al., Neuron, 2016, 89, 449-460; Whitmore, A. et al., Cell Death Differ., 2003, 10, 260-261, each of which is incorporated herein by reference in its entirety). During Wallerian degeneration, nerves undergo selective degradation of axon segments distal to the injury, while proximal axon segments and cell bodies remain intact. Axon degeneration after injury is mediated by the transcription factors NMNAT2, NAD +, and is characterized by the progressive depletion of ATP followed by neurofilament proteolysis and axonal fragmentation that occurs approximately 8-24 hours after the initial injury (Gerdts, J., et al., Neuron, 2016, 89, 449-460, incorporated herein by reference in its entirety).

[0052] It has recently been discovered that knocking down or eliminating the expression of SARM1 leads to long-term protection of sensory neurons against injury-induced axonal degeneration (Gerdts et al., J. Neurosci, 2013, 33, 13569-13580, incorporated herein by reference in its entirety). Following axonal injury, SARM1 functions as a central severing agent in the axonal degeneration pathway. Activated SARM1 is a highly potent NADase, and within minutes to hours of activation, it induces local axonal NAD production. + Activation of SARM1 via axonal injury or forced dimerization of the SARM1-TIR domain depletes NAD stores, causing a local bioenergetic crisis and subsequent rapid axon degeneration. + promotes rapid and catastrophic depletion of NAD, which is quickly followed by axonal degeneration, thus impairing axonal integrity + This highlights its central role in homeostasis (Gerdts, J., et al., Science, 2015, 348, 453-457). SARM1 regulates this damage-induced NAD both in vitro and in vivo. + SARM1 activation is required for NAD depletion + It causes local axonal degeneration through destruction (Gerdts et al., et al., Science, 2015 348, 452-457; Sasaki et al., J. Biol. Chem. 2015, 290, 17228-17238, each of which is incorporated herein by reference in its entirety).

[0053] The protein sequence of wild-type human SARM1 is as follows: (SEQ ID NO: 1).

[0054] Genetic loss-of-function studies indicate that SARM1 functions as a central executor of the axon degeneration pathway after injury. Genetic deletion or knockout of SARM1 allows axon preservation for more than 14 days after nerve transection (Osterloh, JM, et al., Science, 2012, 337, 481-484; Gerdts, J., et al. J. Neurosci., 2013, 33, 13569-13580, each of which is incorporated herein by reference in its entirety) and also improves the functional outcome of mice after traumatic brain injury (Henninger, N. et al., Brain, 139, 2016, 1094-1105, each of which is incorporated herein by reference in its entirety). In addition to the direct role that SARM1 plays in axonal injury, SARM1 is also required for the axon degeneration observed in chemotherapy-induced peripheral neuropathy (CIPN). Loss of SARM1 blocks CIPN and inhibits both the axonal degeneration and increased pain sensitivity that develop after chemotherapy vincristine treatment (Geisler et al, Brain, 2016, 139, 3092-3108, which is incorporated herein by reference in its entirety).

[0055] SARM1 antisense oligonucleotides In some embodiments, the present disclosure provides antisense oligonucleotides. In some embodiments, the antisense oligonucleotides are RNase H-dependent oligonucleotides, and the antisense oligonucleotides induce mRNA degradation. In some embodiments, the antisense oligonucleotides are sterically blocking oligonucleotides, and the antisense oligonucleotides physically prevent or inhibit the progression of splicing or translation mechanisms. The antisense oligonucleotides of the present disclosure can hybridize to a target nucleic acid and produce at least one antisense activity. In some embodiments, the antisense activity includes degradation of the target nucleic acid by RNase H. In some embodiments, the antisense activity includes an antisense oligonucleotide that physically prevents or inhibits the progression of splicing or translation mechanisms.

[0056] In some embodiments, antisense oligonucleotides specifically hybridize to one or more target nucleic acids. In some embodiments, the target nucleic acid comprises a full-length mRNA. In some embodiments, the target nucleic acid comprises a region of an mRNA. In some embodiments, antisense oligonucleotides of the present invention hybridize to the same target nucleic acid. In some embodiments, antisense oligonucleotides of the present invention hybridize to different target nucleic acids. In some embodiments, specifically hybridizing antisense oligonucleotides have a nucleobase sequence that includes a region with sufficient complementarity to the target nucleic acid to enable hybridization and provide antisense activity and insufficient complementarity to any non-targets to avoid non-specific hybridization to any non-target nucleic acid sequences under conditions where specific hybridization is desired (e.g., under physiological conditions for in vivo or therapeutic use, and under conditions under which the assay is performed in the case of an in vitro assay).

[0057] In some embodiments, the present disclosure provides antisense oligonucleotides that are fully complementary to a target nucleic acid over the entire length of the antisense oligonucleotide. In some embodiments, the antisense oligonucleotide is 99% complementary to a target nucleic acid over the entire length of the antisense oligonucleotide. In some embodiments, the antisense oligonucleotide is 95% complementary to a target nucleic acid over the entire length of the antisense oligonucleotide. In some embodiments, the antisense oligonucleotide is 90% complementary to a target nucleic acid over the entire length of the antisense oligonucleotide. In some embodiments, the antisense oligonucleotide is 85% complementary to a target nucleic acid over the entire length of the antisense oligonucleotide. In some embodiments, the antisense oligonucleotide is 80% complementary to a target nucleic acid over the entire length of the antisense oligonucleotide. In some embodiments, the antisense oligonucleotide is 80%-99% complementary to a target nucleic acid over the entire length of the antisense oligonucleotide. In some embodiments, the antisense oligonucleotide is fully complementary to a target nucleic acid and comprises a region that is at least 80% complementary to the target nucleic acid over the entire length of the oligonucleotide. In some embodiments, the region of full complementarity is 6-14 nucleobases in length.

[0058] In some embodiments, the antisense oligonucleotide comprises a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-26. In some embodiments, the antisense oligonucleotide comprises a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-26. In some embodiments, the antisense oligonucleotide comprises a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-26. In some embodiments, the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3-26. In some embodiments, the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3-2081.

[0059] In some embodiments, the antisense oligonucleotide comprises a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38, and 39. In some embodiments, the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3-2412.

[0060] In some embodiments, the antisense oligonucleotide comprises a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. In some embodiments, the antisense oligonucleotide comprises a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. In some embodiments, the antisense oligonucleotide comprises a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. In some embodiments, the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549.

[0061] In some embodiments, the target nucleic acid is an endogenous RNA molecule. In some embodiments, the target nucleic acid is an exogenous RNA molecule. In some embodiments, the target nucleic acid is a pre-mRNA. In some embodiments, the target nucleic acid is a mature mRNA. In some embodiments, the target nucleic acid is a SARM1 transcript.

[0062] In some embodiments, the antisense oligonucleotides of the present disclosure are complementary to a region of SARM1 mRNA. In some embodiments, the antisense oligonucleotides are complementary to a region of the 5' untranslated region (UTR) of SARM1 mRNA. In some embodiments, the antisense oligonucleotides are complementary to the coding region of SARM1 mRNA. In some embodiments, the antisense oligonucleotides are complementary to a region of the 3' UTR of SARM1 mRNA. In some embodiments, the antisense oligonucleotides of the present disclosure are complementary to a region of SARM1 mRNA as shown in Figure 1 and Table 1. Table 1 includes exemplary SARM1 antisense oligonucleotide sequences, complementary regions of SAMR1 mRNA (5' UTR, coding region (CDS), or 3' UTR), oligonucleotide start positions (start position from the 5' end of SARM1 mRNA), and code letters corresponding to the antisense oligonucleotides in Figure 1. [Table 1]

[0063] In some embodiments, the antisense oligonucleotides of the present disclosure comprise oligonucleotides having a nucleobase sequence consisting of 8 to 30 linked nucleosides and including a complementary region comprising at least 8 contiguous nucleobases that is complementary to a target region of equal length of the SARM1 transcript.

[0064] In some embodiments, the antisense oligonucleotide comprises RNA. In some embodiments, the antisense oligonucleotide comprises DNA. In some embodiments, the antisense oligonucleotide comprises both RNA and DNA. In some embodiments, the antisense oligonucleotide is 5 to 100 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 90 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 80 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 70 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 60 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 50 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 40 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 30 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 25 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 20 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 15 nucleotides in length. In some embodiments, the antisense oligonucleotide is 5 to 10 nucleotides in length. In some embodiments, the antisense oligonucleotide is 10 to 100 nucleotides in length. In some embodiments, the antisense oligonucleotide is 15 to 100 nucleotides in length. In some embodiments, the antisense oligonucleotide is 20 to 100 nucleotides in length. In some embodiments, the antisense oligonucleotide is 25 to 100 nucleotides in length. In some embodiments, the antisense oligonucleotide is 30 to 100 nucleotides in length.In some embodiments, the antisense oligonucleotide is 40-100 nucleotides in length. In some embodiments, the antisense oligonucleotide is 50-100 nucleotides in length. In some embodiments, the antisense oligonucleotide is 60-100 nucleotides in length. In some embodiments, the antisense oligonucleotide is 70-100 nucleotides in length. In some embodiments, the antisense oligonucleotide is 90-100 nucleotides in length. In some embodiments, the antisense oligonucleotide is 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 nucleotides in length. In some embodiments, the antisense oligonucleotide is 20 nucleotides in length.

[0065] In some embodiments, the antisense oligonucleotide comprises one or more modifications. In some embodiments, the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. In some embodiments, any antisense oligonucleotide described herein comprises an internucleotide linkage of the following pattern (5' to 3'): R S R O R S R O R S D S D S D S D S D S D S D S D S D S D S R O R S R O R S , where R Sis RNA (2'-MOE) phosphorothioate linkage, and R O is an RNA (2'-MOE) phosphodiester bond, and D S is a DNA phosphorothioate bond. In some embodiments, the antisense oligonucleotide comprises SEQ ID NO: 2410. In some embodiments, the antisense oligonucleotide comprises SEQ ID NO: 2411. In some embodiments, the antisense oligonucleotide comprises SEQ ID NO: 2412.

[0066] Methods for Treating Neurodegeneration The methods described herein include treating and / or preventing axonal degeneration in a subject. In some embodiments, the methods described herein include administering a SARM1 antisense agent to a subject. In some embodiments, the methods described herein include administering a SARM1 antisense agent to a subject. The methods described herein include administering a SARM1 antisense agent to a subject at risk of developing a neurodegenerative disease or disorder. In some embodiments, the SARM1 inhibitor is a SARM1 antisense oligonucleotide.

[0067] Diseases, Disorders, and Conditions In some embodiments, the present disclosure provides methods for treating a subject suffering from one or more diseases, disorders, or conditions. In some embodiments, the one or more diseases, disorders, or conditions are mediated by SARM1.

[0068] In some embodiments, the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration.

[0069] In some embodiments, the neurodegenerative disease or disorder comprises an acute disease or disorder of the PNS. In some embodiments, the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or chemical or chemotherapeutic injury. In some embodiments, the mechanical injury comprises a compressive or constriction injury or pressure injury. In some embodiments, the compressive or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. In some embodiments, the pressure injury comprises pressure involving the superficial peroneal nerve, pressure due to a tumor, or elevated intraocular pressure. In some embodiments, the chemical or chemotherapeutic agent comprises a cytotoxic anticancer agent, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based agent, or auristatin. In some embodiments, the epothilone is ixabepilone. In some embodiments, the taxane is paclitaxel or docetaxel. In some embodiments, the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. In some embodiments, the proteasome inhibitor is bortezomib. In some embodiments, the platinum-based drug is cisplatin, oxaliplatin, or carboplatin. In some embodiments, the auristatin is conjugated monomethyl auristatin E.

[0070] In some embodiments, the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. In some embodiments, the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder.

[0071] In some embodiments, the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies.

[0072] In some embodiments, the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiencies, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barre syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa.

[0073] In some embodiments, the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes.

[0074] In some embodiments, the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, liver failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders.

[0075] In some embodiments, the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS, hi some embodiments, the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis.

[0076] In some embodiments, ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy.

[0077] In some embodiments, traumatic CNS injury includes spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush or thin axons.

[0078] In some embodiments, viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia).

[0079] In some embodiments, the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS.

[0080] In some embodiments, the chronic disease or disorder of the CNS is Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukoencephalopathy, neuropathy, including neuromalacia, hereditary ataxia, noise-induced hearing loss, congenital hearing loss, age-related hearing loss, Creutzfeldt-Jakob disease, transmissible spongiform encephalopathy, dementia with Lewy bodies, frontotemporal dementia, amyloidosis, diabetic neuropathy, globoid cell leukodystrophy (Krabbe disease), Bassen-Kornzweig syndrome, transverse myelitis, motor neuron disease, spinocerebellar ataxia, pre-eclampsia, hereditary spastic paraplegia, spastic paraplegia, familial spastic paraplegia, French colonial disease, Strampel-Lorraine disease, non-alcoholic steatohepatitis (NASH), adrenomyeloneuropathy, progressive supranuclear palsy (PSP), Friedreich's ataxia, or spinal cord injury.

[0081] In some embodiments, the chronic disease or disorder of the CNS comprises an optic neuropathy, a traumatic CNS injury, or a metabolic disease or disorder.

[0082] In some embodiments, optic neuropathy comprises acute optic neuropathy (AON), hereditary or idiopathic retinal conditions, Leber's congenital amaurosis (LCA), Leber's hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier's optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide.

[0083] In some embodiments, the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE).

[0084] In some embodiments, the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, liver failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders.

[0085] In some embodiments, the neurodegenerative disease or disorder comprises a disease associated with neurodegeneration, hi some embodiments, the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes.

[0086] In some embodiments, the subject is a human. In some embodiments, the subject is at risk of developing a condition characterized by axonal degeneration. In some embodiments, the subject is a patient with one or more risk factors for developing a condition accompanied by axonal degeneration. In some embodiments, the one or more risk factors for developing a condition accompanied by axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof.

[0087] In some embodiments, the one or more genetic risk factors for neurodegeneration include one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof.

[0088] In some embodiments, the subject has a condition characterized by axonal degeneration. In some embodiments, the subject has been diagnosed with a condition characterized by axonal degeneration.

[0089] In some embodiments, engaging in one or more high-risk activities includes participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing.

[0090] In some embodiments, the one or more biomarkers of neurodegeneration include a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; constitutive cADPR levels in the subject; levels of albumin, amyloid-β (Aβ) 38, Aβ 40, Aβ 42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP) α, sAPP β, soluble triggering receptor expressed on myeloid cells (sTREM) 2, phospho-tau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and CC in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. including levels of Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL) 6.

[0091] In some embodiments, the therapies provided herein are characterized in that, when administered to a population of subjects, the therapy reduces one or more symptoms or characteristics of neurodegeneration. For example, in some embodiments, the relevant symptom or characteristic may be selected from the group consisting of the extent, rate, and / or timing of neuronal destruction.

[0092] subject In some embodiments, the compositions described herein are administered to a subject suffering from or susceptible to a disease, disorder, or condition described herein. In some embodiments, the disease, disorder, or condition is characterized by axonal degeneration, such as one of the conditions mentioned herein.

[0093] In some embodiments, the subject to whom a composition described herein is administered exhibits one or more signs or symptoms associated with axonal degeneration. In some embodiments, the subject does not exhibit signs or symptoms of neurodegeneration.

[0094] In some embodiments, provided methods include administering the composition to a patient in need thereof. In some such embodiments, the patient is at risk of developing a condition characterized by axonal degeneration. In some embodiments, the patient has a condition characterized by axonal degeneration. In some embodiments, the patient has been diagnosed with a condition characterized by axonal degeneration.

[0095] In some embodiments, provided methods include administering a composition described herein to a patient population in need thereof. In some embodiments, the population is taken from individuals who engage in activities that increase the likelihood of traumatic nerve injury. In some embodiments, the population is taken from athletes who engage in contact sports or other high-risk activities.

[0096] In some embodiments, the subject is at risk of developing a condition characterized by axonal degeneration. In some embodiments, the subject is identified as being at risk for axonal degeneration based on, for example, the subject's genotype, a diagnosis of a condition associated with axonal degeneration, and / or exposure to agents and / or conditions that induce axonal degeneration.

[0097] In some embodiments, the patient is at risk of developing a neurodegenerative disorder. In some embodiments, the patient is elderly. In some embodiments, the patient is known to have genetic risk factors for neurodegeneration. In some embodiments, the patient has a family history of neurodegenerative disease. In some embodiments, the patient expresses one or more copies of a known genetic risk factor for neurodegeneration (Lill et al., Semin Neurol, 2011, 31:531-541, incorporated herein by reference in its entirety). In some embodiments, the patient is taken from a population with a high incidence of neurodegeneration. In some embodiments, the patient has a hexanucleotide repeat expansion in open reading frame 72 of chromosome 9. In some embodiments, the patient has one or more copies of an apolipoprotein E4 (ApoE4) allele.

[0098] In some embodiments, the patient has one or more copies of a disease-causing mutation in APP, PSEN1, or PSEN2. In some embodiments, the patient has one or more copies of a disease-associated polymorphism in or near the following genes: ABCA7, APOE, BIN1, CD2AP, CD33, CLU, CR1, MS4A4E, MS4A6A, and PICALM.

[0099] In some embodiments, the patient has one or more copies of a disease-causing mutation in EIF4G1, LRRK2, PARK2, PARK7, PINK1, SNCA, or VPS35. In some embodiments, the patient has one or more copies of a disease-associated polymorphism in or near the following genes: ACMSD / TMEM163, BST1, CCDC62 / HIP1R, FAM47E / STBD1, GAK / DGKQ, GBA, GPNMB, QWA_8p22 / FGF20, HLA-II, LRRK2, MAPT, MCCC1 / LAMP3, PARK16, SETD1A / STX1B, SNCA, SREBF1 / RAI1, STK29, and SYT11 / RAB25.

[0100] In some embodiments, the patient has one or more copies of a disease-causing mutation in C9ORF72, CHMP2B, GRN, MAPT, or VCP. In some embodiments, the patient has one or more copies of a disease-associated polymorphism in or near the TMEM106B gene.

[0101] In some embodiments, the patient has one or more copies of a disease-causing mutation in ANG, ALS2, C9ORF72, FIG4, FUS, OPTN, SETX, SOD1, SPG11, TARDBP, UBQLN2, VAPB, or VCP. In some embodiments, the patient has one or more copies of a disease-associated polymorphism in or near the following genes: GWA_9p21.2, UNC13A, and ATXN2.

[0102] In some embodiments, the subject to which the compositions described herein are administered may be or may include a subject suffering from or susceptible to a neurodegenerative disease, disorder, or condition. In some embodiments, the neurodegenerative disease, disorder, or condition may be or may include traumatic nerve injury. In some embodiments, the traumatic nerve injury is blunt force trauma, closed head injury, open head injury, exposure to impact and / or explosive force, or penetrating injury to or within the brain cavity or innervated area of ​​the body. In some embodiments, the traumatic nerve injury is a force that deforms, stretches, crushes, or rotates axons.

[0103] In some embodiments, the subject engages in an activity identified as a risk factor for neurodegeneration, for example, a subject who engages in a contact sport or occupation that carries a high chance of traumatic nerve injury.

[0104] For example, the subject may be a patient who is undergoing or being prescribed chemotherapy for peripheral neuropathy.Examples of chemotherapeutic agents include but are not limited to thalidomide, epothilone (e.g., ixabepilone), taxane (e.g., paclitaxel and docetaxel), vinca alkaloid (e.g., vinblastine, vinorelbine, vincristine and vindesine), proteasome inhibitor (e.g., bortezomib), auristatin (e.g., auristatin E) and platinum-based drugs (e.g., cisplatin, oxaliplatin and carboplatin).

[0105] In some embodiments, provided methods include administering a composition as described herein to a patient or patient population based on the presence or absence of one or more biomarkers. In some embodiments, provided methods further include monitoring the levels of the biomarkers in the patient or patient population and adjusting the dosing regimen accordingly.

[0106] Administration Those skilled in the art will understand that in some embodiments, the exact amount of a particular SARM1 antisense agent included in and / or delivered by administration of a pharmaceutical composition or regimen as described herein can be selected by a physician and may vary for different subjects, taking into account, for example, one or more of the subject's species, age, and general condition, and / or the identity of the particular SARM1 antisense agent, its method of administration, etc. Alternatively, in some embodiments, the amount of SARM1 antisense agent included in and / or delivered by administration of a pharmaceutical composition or regimen as described herein can be standardized across a relevant patient population (e.g., all patients, all patients of a particular age or stage of disease, or all patients expressing a particular biomarker, etc.).

[0107] The SARM1 antisense agent or composition provided by the present disclosure is preferably formulated in dosage unit form for ease of administration and uniformity of dosage.The term "dosage unit form" used herein refers to a physically discrete unit of drug that is appropriate for the patient being treated.However, it will be understood that the total daily use amount of the SARM1 antisense agent and composition provided by the present disclosure will be determined by the attending physician within the scope of sound medical judgment.The specific effective dose level for any specific patient or organism will depend on various factors, including the disorder being treated and the severity of the disorder, the clinical condition of the individual patient, the cause of the disorder, the activity of the SARM1 antisense agent used, the specific composition used, the patient's age, weight, general health, sex, and diet, the timing of administration of the specific SARM1 antisense agent used, the delivery site, administration route, and excretion rate of the drug, the duration of treatment, the drugs used in combination with or simultaneously with the specific SARM1 antisense agent used, and similar factors well known in the medical field. The effective amount of SARM1 antisense agent to be administered will be governed by such considerations and will be the minimum amount required to inhibit SARM1 activity, inflammatory activity, necroptosis, or immune activity necessary to prevent or treat an undesirable disease or disorder, such as neurodegeneration or traumatic nerve injury.

[0108] In some embodiments, the compositions of the present disclosure can be administered orally, parenterally, by inhalation spray, topically, rectally, nasally, buccally, intravaginally, or via an implanted reservoir. As used herein, the term "parenteral" includes subcutaneous, intravenous, intramuscular, intra-articular, intra-synovial, intrasternal, intrathecal, intrahepatic, intradermal, intraocular, intravitreal, intralesional, and intracranial injection or infusion techniques. Preferably, the compositions are administered via intrathecal, intraventricular, intracerebroventricular, intracisternal, intraparenchymal, or intravitreal injection.

[0109] In some embodiments, the pharmaceutically acceptable compositions of the present disclosure may also be administered topically, particularly when the target of treatment includes areas or organs readily accessible by topical application, including diseases of the eye, the skin, or the lower intestinal tract, for each of which suitable topical formulations are readily prepared.

[0110] In certain embodiments, the daily dose is given as a single dose, or as divided doses 2 to 6 times daily, or in sustained-release form. This dosing regimen can be adjusted to provide the optimal therapeutic response. In some embodiments, the compositions of the present disclosure can be delivered 4 times a week, 3 times a week, 2 times a week, once a week, every 10 days, every 2 weeks, every 3 weeks, or more preferably every 4 weeks, every month, every 6 weeks, every 8 weeks, every other month, every 3 months, every 4 months, every 6 months, every 8 months, every 9 months, or once a year.

[0111] The compositions of the present disclosure can be administered in combination with other therapeutic agents.These additional agents can be administered separately from the SARM1 antisense agent or its composition as part of a multiple-dose regimen.Alternatively, these agents can be part of a single dosage form and mixed together with the SARM1 antisense agent provided in a single composition.When administered as part of a multiple-dose regimen, the two active agents can be administered simultaneously, consecutively, or within a certain period of each other, usually within 5 hours of each other.

[0112] It should also be understood that the specific administration and treatment regimen for any particular patient will depend on a variety of factors, including the activity of the particular SARM1 antisense agent used, age, body weight, general health, sex, diet, time of administration, rate of excretion, drug combination, and the judgment of the treating physician, and the severity of the particular disease being treated. In some embodiments, the amount of a SARM1 antisense agent of the present disclosure in a composition will also depend on the particular SARM1 antisense agent in the composition.

[0113] In some embodiments, the SARM1 antisense agents described herein can be used in combination with one or more other therapies to treat related diseases, disorders, or conditions. In some embodiments, the administration of the SARM1 antisense agent is changed when used in combination therapy compared to when administered as a monotherapy. Alternatively or additionally, in some embodiments, the therapy administered in combination with the SARM1 antisense agent described herein is administered according to a different regimen or protocol than when administered alone or in combination with one or more therapies other than the SARM1 antisense agents of the present disclosure. In some embodiments, a composition comprising an additional therapeutic agent, the additional therapeutic agent, and a provided SARM1 antisense agent that can act synergistically can act synergistically. In some embodiments, one or both therapies used in a combination regimen are administered at a lower level or less frequently than when used as a monotherapy.

[0114] In some embodiments, the present disclosure relates to a method for treating, preventing, and / or ameliorating a neurodegenerative disease, disorder, or condition, comprising: i) providing a) a subject diagnosed with, at risk for, or exhibiting symptoms of a neurodegenerative disease, disorder, or condition; and b) a combination comprising a SARM1 antisense oligonucleotide and a SARM1 inhibitor. In some embodiments, the present disclosure provides a combination therapy comprising a SARM1 antisense oligonucleotide and a SARM1 inhibitor; and ii) administering the combination to the subject under conditions such that the neurodegenerative disease, disorder, or condition is reduced. In some embodiments, the SARM1 antisense oligonucleotide and the SARM1 inhibitor act synergistically in treating, preventing, and / or ameliorating the neurodegenerative disease, disorder, or condition. In some embodiments, the SARM1 inhibitor is a small molecule.

[0115] In some embodiments, the present disclosure relates to a method of treating, preventing, and / or ameliorating a neurodegenerative disease, disorder, or condition, comprising: i) providing to a subject a) diagnosed with, at risk for, or exhibiting symptoms of a neurodegenerative disease, disorder, or condition, and b) a combination comprising a SARM1 antisense oligonucleotide and an NAD+ or NAD+ precursor (e.g., NR, NRH, NA, NaR, NAM, NMN, NaMN, TRP, vitamin B3, or NAAD); and ii) administering the combination to the subject under conditions such that the neurodegenerative disease, disorder, or condition is alleviated. In some embodiments, the disclosure provides a combination therapy comprising a SARM1 antisense oligonucleotide and an NAD+ or NAD+ precursor (e.g., NR, NRH, NA, NaR, NAM, NMN, NaMN, TRP, vitamin B3, or NAAD). In some embodiments, the SARM1 antisense oligonucleotide and NAD+ or an NAD+ precursor (e.g., NR, NRH, NA, NaR, NAM, NMN, NaMN, TRP, vitamin B3, or NAAD) act synergistically in treating, preventing, and / or ameliorating a neurodegenerative disease, disorder, or condition.

[0116] In some embodiments, the present disclosure relates to a method of treating, preventing, and / or ameliorating a neurodegenerative disease, disorder, or condition, comprising: i) providing to a subject a) diagnosed with, at risk for, or exhibiting symptoms of a neurodegenerative disease, disorder, or condition, and b) a combination comprising a SARM1 antisense oligonucleotide and any biologic known in the art (e.g., but not limited to, an antibody, an aptamer, a trophic factor, or an antisense oligonucleotide against a target other than SARM1); and ii) administering the combination to the subject under conditions such that the neurodegenerative disease, disorder, or condition is reduced.

[0117] In some embodiments, the SARM1 antisense agents and / or compositions comprising a SARM1 agent described herein are administered with chemotherapeutic agents, including but not limited to alkylating agents, anthracyclines, taxanes, epothilones, histone deacetylase inhibitors, topoisomerase inhibitors, kinase inhibitors, nucleotide analogs, peptide antibiotics, platinum-based agents, retinoids, vinca alkaloids and derivatives. In some embodiments, the SARM1 antisense agents and / or compositions described herein are administered in combination with a PARP inhibitor.

[0118] Pharmaceutical Composition In some embodiments, the present invention provides pharmaceutical compositions comprising one or more antisense agents. In some embodiments, the pharmaceutical composition comprises a suitable pharmaceutically acceptable diluent or carrier. In some embodiments, the pharmaceutical composition comprises sterile saline and one or more antisense agents. In some embodiments, the pharmaceutical composition consists of sterile saline and one or more antisense agents. In some embodiments, the sterile saline is pharmaceutical-grade saline. In some embodiments, the pharmaceutical composition comprises sterile water and one or more antisense agents. In some embodiments, the pharmaceutical composition consists of sterile water and one or more antisense agents. In some embodiments, the sterile saline is pharmaceutical-grade water. In some embodiments, the pharmaceutical composition comprises phosphate-buffered saline (PBS) and one or more antisense agents. In some embodiments, the pharmaceutical composition consists of sterile phosphate-buffered saline (PBS) and one or more antisense agents. In some embodiments, the sterile saline is pharmaceutical-grade PBS.

[0119] In some embodiments, the antisense agent may be mixed with pharmaceutically acceptable active and / or inactive substances for the preparation of a pharmaceutical composition or formulation. The composition and method for formulating the pharmaceutical composition will depend on several criteria, including, but not limited to, the route of administration, the extent of the disease, or the dose to be administered.

[0120] Pharmaceutical compositions comprising antisense agents disclosed herein include any pharmaceutically acceptable salts, esters, or salts of such esters. In some embodiments, pharmaceutical compositions comprising antisense agents include one or more oligonucleotides that can provide (directly or indirectly) biologically active metabolites or residues thereof when administered to animals, including humans. Thus, for example, the present disclosure also encompasses pharmaceutically acceptable salts of antisense agents, prodrugs, pharmaceutically acceptable salts of such prodrugs, and other bioequivalents. Suitable pharmaceutically acceptable salts include, but are not limited to, sodium salts and potassium salts.

[0121] Prodrugs may involve the incorporation of additional nucleosides at one or both ends of an oligomeric compound that are cleaved by endogenous nucleases in the body to form the active antisense oligomeric agent.

[0122] Lipid moieties have been used in nucleic acid therapy in a variety of ways. In certain such methods, nucleic acids are introduced into preformed liposomes or lipoplexes consisting of a mixture of cationic lipids and neutral lipids. In some methods, DNA complexes with monocationic or polycationic lipids are formed without the presence of neutral lipids. In some embodiments, the lipid moiety is selected to increase the distribution of pharmaceuticals to specific cells or tissues. In some embodiments, the lipid moiety is selected to increase the distribution of pharmaceuticals to CNS tissues. In some embodiments, the lipid moiety is selected to increase the distribution of pharmaceuticals to PNS tissues.

[0123] In some embodiments, the pharmaceutical compositions provided herein comprise one or more modified oligonucleotides and one or more excipients. In certain such embodiments, the excipient is selected from water, saline, alcohol, polyethylene glycol, gelatin, lactose, amylase, magnesium stearate, talc, silicic acid, viscous paraffin, hydroxymethylcellulose, and polyvinylpyrrolidone.

[0124] In some embodiments, the pharmaceutical compositions provided herein include a delivery system. Examples of delivery systems include, but are not limited to, liposomes and emulsions. Certain delivery systems are useful for preparing certain pharmaceutical compositions, including those containing hydrophobic compounds. In some embodiments, certain organic solvents, such as dimethyl sulfoxide, are used.

[0125] In some embodiments, the pharmaceutical compositions provided herein comprise one or more tissue-specific delivery molecules designed to deliver one or more pharmaceutical agents of the present invention to a particular tissue or cell type. For example, in some embodiments, the pharmaceutical compositions comprise liposomes coated with a tissue-specific antibody.

[0126] In some embodiments, the pharmaceutical compositions provided herein contain a cosolvent system. Some such cosolvent systems include, for example, benzyl alcohol, a nonpolar surfactant, a water-miscible organic polymer, and an aqueous phase. In some embodiments, such cosolvent systems are used for hydrophobic compounds. A non-limiting example of such a cosolvent system is the VPD cosolvent system, which is a solution of 3% w / v benzyl alcohol, 8% w / v of the nonpolar surfactant Polysorbate 80™, and 65% w / v polyethylene glycol 300 in absolute ethanol. The ratios of such cosolvent systems can be varied considerably without significantly altering their solubility and toxicity characteristics. Furthermore, the identity of the cosolvent components can be altered. For example, other surfactants can be substituted for Polysorbate 80™. The fraction size of the polyethylene glycol can be varied. Other biocompatible polymers can be substituted for polyethylene glycol, e.g., polyvinylpyrrolidone. Other sugars or polysaccharides can be substituted for dextrose.

[0127] In some embodiments, the pharmaceutical compositions provided herein are prepared for oral administration. In some embodiments, the pharmaceutical compositions are prepared for buccal administration. In some embodiments, the pharmaceutical compositions are prepared for administration by injection (e.g., intravenous, subcutaneous, intramuscular, etc.). In certain such embodiments, the pharmaceutical compositions include a carrier and are formulated in an aqueous solution such as water, or a physiologically compatible buffer such as Hank's solution, Ringer's solution, or physiological saline buffer. In some embodiments, other ingredients (e.g., ingredients that aid solubility or function as preservatives) are included. In some embodiments, injectable suspensions are prepared using appropriate liquid carriers, suspending agents, etc. Certain pharmaceutical compositions for injection are presented in unit dosage form, e.g., in ampoules or multi-dose containers. Certain pharmaceutical compositions for injection are suspensions, solutions, or emulsions in oily or aqueous vehicles and may contain formulatory agents such as suspending agents, stabilizers, and / or dispersing agents. Specific solvents suitable for use in injectable pharmaceutical compositions include, but are not limited to, lipophilic solvents and fatty oils such as sesame oil, synthetic fatty acid esters such as ethyl oleate or triglycerides, and liposomes. Aqueous injection suspensions may contain substances that increase the viscosity of the suspension, such as sodium carboxymethylcellulose, sorbitol, or dextran. Optionally, such suspensions may also contain suitable stabilizers or agents that increase the solubility of pharmaceuticals, allowing for the preparation of highly concentrated solutions. In some embodiments, pharmaceutical compositions are prepared for transmucosal administration. In certain such embodiments, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are known in the art.

[0128] In some embodiments, the pharmaceutical compositions provided herein comprise a therapeutically effective amount of an oligonucleotide. In some embodiments, the therapeutically effective amount is sufficient to prevent, alleviate, or ameliorate symptoms of a disease, or to prolong the survival of the subject being treated. Determining a therapeutically effective amount is well within the capabilities of those skilled in the art.

[0129] In some embodiments, one or more modified oligonucleotides provided herein are formulated as prodrugs. In some embodiments, upon in vivo administration, the prodrug is chemically converted to a biologically, pharmaceutically, or therapeutically more active form of the oligonucleotide. In some embodiments, prodrugs are useful because they are easier to administer than the corresponding active form. For example, in certain instances, a prodrug may be more bioavailable (e.g., via oral administration) than the corresponding active form. In some cases, a prodrug may have improved solubility compared to the corresponding active form. In some embodiments, a prodrug is less water-soluble than the corresponding active form. In some cases, such prodrugs have superior permeability across cell membranes where water solubility is detrimental to mobility. In some embodiments, the prodrug is an ester. In certain such embodiments, the ester is metabolically hydrolyzed to a carboxylic acid upon administration. In certain instances, the carboxylic acid-containing compound is the corresponding active form. In certain embodiments, the prodrug comprises a short peptide (polyamino acid) bound to an acid group. In certain such embodiments, the peptide is cleaved upon administration to form the corresponding active form.

[0130] In some embodiments, the present invention provides compositions and methods for reducing the amount or activity of a target nucleic acid in a cell. In some embodiments, the cell is in an animal. In some embodiments, the animal is a mammal. In some embodiments, the animal is a rodent. In some embodiments, the animal is a primate. In some embodiments, the animal is a non-human primate. In some embodiments, the animal is a human.

[0131] In some embodiments, the present invention provides a method for administering a pharmaceutical composition containing an oligomeric agent of the present invention to an animal. Suitable routes of administration include, but are not limited to, oral, rectal, transmucosal, intestinal, enteral, topical, suppository, inhalation, intrathecal, intracerebroventricular, intraperitoneal, intranasal, intraocular, intratumoral, intracisternal, and parenteral (e.g., intravenous, intramuscular, intramedullary, and subcutaneous). In some embodiments, intramedullary pharmaceuticals are administered to achieve local exposure rather than systemic exposure. For example, pharmaceutical compositions can be injected directly into the area of ​​the desired effect (e.g., eye, ear).

[0132] In some embodiments, the pharmaceutical composition is administered to an animal having at least one symptom associated with a neurodegenerative disease or disorder. In some embodiments, such administration results in the improvement of at least one symptom. In some embodiments, administration of the pharmaceutical composition to an animal results in a decrease in SARM1 mRNA in the cells of the animal. In some embodiments, such administration results in a decrease in SARM1 protein.

[0133] Illustrative Embodiments 1. An antisense oligonucleotide comprising a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 3 to 26. 2. The antisense oligonucleotide of embodiment 1, comprising a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 3 to 26. 3. The antisense oligonucleotide of embodiment 1 or 2, comprising a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 3 to 26. 4. The antisense oligonucleotide according to any one of embodiments 1 to 3, comprising a sequence selected from the group consisting of SEQ ID NOs: 3 to 26. 5. An antisense oligonucleotide comprising a sequence selected from the group consisting of SEQ ID NOs: 3 to 2081. 6. The antisense oligonucleotide of any one of embodiments 1 to 5, wherein the antisense oligonucleotide comprises one or more modifications. 7. The antisense oligonucleotide of embodiment 6, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 8. A pharmaceutical composition comprising the antisense oligonucleotide of any one of the preceding embodiments. 9. The pharmaceutical composition of embodiment 8, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 10. A method for treating and / or preventing axonal degeneration in a subject, comprising: A method comprising administering to a subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1). 11. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1. 12. The method of embodiment 10 or 11, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 13. The method of any one of embodiments 10-12, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-26. 14. The method of any one of embodiments 10 to 13, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 3 to 26. 15. The method of any one of embodiments 10-14, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-26. 16. The method of any one of embodiments 10 to 15, wherein the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3 to 26. 17. The method of any one of embodiments 10-12, wherein the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3-2081. 18. The method of any one of embodiments 10 to 17, wherein the antisense oligonucleotide comprises one or more modifications. 19. The method of embodiment 18, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 20. The method of any one of embodiments 10 to 19, wherein administering an antisense oligonucleotide reduces the level of SARM1 mRNA in the subject. 21. The method of any one of embodiments 10 to 19, wherein administering an antisense oligonucleotide reduces the level of SARM1 protein in the subject. 22. The method of any one of embodiments 11-21, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 23. The method of any of embodiments 11-21, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 24. The method of embodiment 23, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 25. The method of embodiment 23, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. 26. The method of embodiment 24, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiencies, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 27. The method of embodiment 24, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 28. The method of embodiment 24, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 29. The method of any one of embodiments 11-22, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 30. The method of embodiment 29, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or chemical or chemotherapeutic injury. 31. The method of embodiment 30, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 32. The method of embodiment 31, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 33. The method of embodiment 31, wherein the pressure injury comprises pressure involving the superficial peroneal nerve, pressure from a tumor, or elevated intraocular pressure. 34. The method of embodiment 30, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 35. The method of embodiment 34, wherein the epothilone is ixabepilone. 36. The method of embodiment 34, wherein the taxane is paclitaxel or docetaxel. 37. The method of embodiment 34, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 38. The method of embodiment 34, wherein the proteasome inhibitor is bortezomib. 39. The method of embodiment 34, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 40. The method of embodiment 34, wherein the auristatin is conjugated monomethyl auristatin E. 41. The method of any one of embodiments 11-22, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 42. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 42. The method of embodiment 41, comprising the treatment of any of a variety of conditions including, but not limited to, neurodegenerative disorders, neurological disorders, neurological conditions, neurological disorders, neurological disorders including ... 43. The method of embodiment 41, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 44. The method of embodiment 43, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber congenital amaurosis (LCA), Leber hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 45. The method of embodiment 43, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 46. ​​The method of embodiment 43, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 47. The method of any one of embodiments 11-22, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 48. The method of embodiment 47, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 49. The method of embodiment 48, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 50. The method of embodiment 48, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush or thin axons. 51. The method of embodiment 48, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 52. The method of any one of embodiments 11-22, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 53. The method of any one of embodiments 10 to 52, wherein the subject is a human. 54. The method of any one of embodiments 10 to 53, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 55. The method of embodiment 54, wherein the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 56. The method of embodiment 55, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. 57. The method of embodiment 55, wherein engaging in one or more high-risk activities comprises participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate Frisbee, volleyball, and / or windsurfing. 58. One or more biomarkers of neurodegeneration: a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and a level of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 59. An antisense oligonucleotide comprising a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38 and 39. 60. The antisense oligonucleotide of embodiment 59, comprising a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38 and 39. 61. The antisense oligonucleotide of embodiment 59 or 60, comprising a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 3-21, 23-26, 38 and 39. 62. The antisense oligonucleotide according to any one of embodiments 59 to 61, comprising a sequence selected from the group consisting of SEQ ID NOs: 3 to 21, 23 to 26, 38 and 39. 63. An antisense oligonucleotide comprising a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. 64. The antisense oligonucleotide of embodiment 63, comprising a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. 65. The antisense oligonucleotide of embodiment 63 or 64, comprising a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. 66. The antisense oligonucleotide of any one of embodiments 63 to 65, comprising a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. 67. An antisense oligonucleotide comprising a sequence selected from the group consisting of SEQ ID NOs: 3 to 2412. 68. The antisense oligonucleotide according to any one of embodiments 59 to 66, wherein the antisense oligonucleotide comprises one or more modifications. 69. The antisense oligonucleotide of embodiment 68, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 70. A pharmaceutical composition comprising the antisense oligonucleotide of any one of the preceding embodiments. 71. A pharmaceutical composition comprising an antisense oligonucleotide according to any one of embodiments 59-70. 72. The pharmaceutical composition according to embodiment 70 or 71, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 73. A method for treating and / or preventing axonal degeneration in a subject, comprising: The method comprises administering to the subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1). 74. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1. 75. The method of embodiment 73 or 74, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 76. The method of any one of embodiments 73 to 75, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 3 to 21, 23 to 26, 38 and 39. 77. The method of any one of embodiments 73 to 76, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 3 to 21, 23 to 26, 38 and 39. 78. The method of any one of embodiments 73 to 77, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 3 to 21, 23 to 26, 38 and 39. 79. The method of any one of embodiments 73 to 78, wherein the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3 to 21, 23 to 26, 38 and 39. 80. The method of any one of embodiments 73 to 75, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. 81. The method of any one of embodiments 73 to 75 and 80, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. 82. The method of any one of embodiments 73-75 and 80-81, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. 83. The method of any one of embodiments 73-75 and 80-82, wherein the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 8, 9, 13, 22, 38, and 549. 84. The method of any one of embodiments 73-75, wherein the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs: 3-2412. 85. The method of any one of embodiments 73-84, wherein the antisense oligonucleotide comprises one or more modifications. 86. The method of embodiment 85, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 87. The method of any one of embodiments 73 to 86, wherein administering an antisense oligonucleotide reduces the level of SARM1 mRNA in the subject. 88. The method of any one of embodiments 73 to 86, wherein the level of SARM1 protein in the subject is reduced by administering an antisense oligonucleotide. 89. The method of any one of embodiments 74-88, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 90. The method of any of embodiments 74-88, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 91. The method of embodiment 90, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 92. The method of embodiment 90, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. 93. The method of embodiment 91, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiency, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 94. The method of embodiment 91, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 95. The method of embodiment 91, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 96. The method of any one of embodiments 74-89, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 97. The method of embodiment 96, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or chemical or chemotherapeutic injury. 98. The method of embodiment 97, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 99. The method of embodiment 98, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 100. The method of embodiment 98, wherein the pressure injury comprises pressure involving the superficial peroneal nerve, pressure from a tumor, or elevated intraocular pressure. 101. The method of embodiment 97, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 102. The method of embodiment 101, wherein the epothilone is ixabepilone. 103. The method of embodiment 101, wherein the taxane is paclitaxel or docetaxel. 104. The method of embodiment 101, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 105. The method of embodiment 101, wherein the proteasome inhibitor is bortezomib. 106. The method of embodiment 101, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 107. The method of embodiment 101, wherein the auristatin is conjugated monomethyl auristatin E. 108. The method of any one of embodiments 74-89, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 109. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 109. The method of embodiment 108, comprising the treatment of any of a variety of conditions, including encephalopathy, noise-induced hearing loss, congenital hearing loss, age-related hearing loss, Creutzfeldt-Jakob disease, transmissible spongiform encephalopathy, dementia with Lewy bodies, frontotemporal dementia, amyloidosis, diabetic neuropathy, globoid cell leukodystrophy (Krabbe disease), Bassen-Kornzweig syndrome, transverse myelitis, motor neuron disease, spinocerebellar ataxia, pre-eclampsia, hereditary spastic paraplegia, spastic paraplegia, familial spastic paraplegia, French colonial disease, Strampel-Lorraine disease, non-alcoholic steatohepatitis (NASH), adrenomyeloneuropathy, progressive supranuclear palsy (PSP), Friedreich's ataxia, or spinal cord injury. 110. The method of embodiment 108, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 111. The method of embodiment 110, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber congenital amaurosis (LCA), Leber hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 112. The method of embodiment 110, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 113. The method of embodiment 110, wherein in some embodiments, the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 114. The method of any one of embodiments 74-89, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 115. The method of embodiment 114, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 116. The method of embodiment 115, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 117. The method of embodiment 115, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush or thin axons. 118. The method of embodiment 115, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 119. The method of any one of embodiments 74-89, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 120. The method of any one of embodiments 73-119, wherein the subject is a human. 121. The method of any one of embodiments 73 to 120, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 122. The method of embodiment 121, wherein the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 123. The method of embodiment 122, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. 124. The method of embodiment 122, wherein engaging in one or more high-risk activities comprises participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing. 125. One or more biomarkers of neurodegeneration: a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and a level of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 126. An antisense oligonucleotide selected from Table 3 for use in the manufacture of a pharmaceutical product. 127. An antisense oligonucleotide selected from Table 3 for use in treating a disease, disorder or injury. 128. The disease, disorder or injury is due to hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathy (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathy, other peripheral neuropathies, diabetes, uremia, AIDS, leprosy, nutritional deficiencies, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, polyarteritis nodosa, chronic pain, or fibromyalgia. , spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgery pain, muscle spasms, back pain, visceral pain, injury pain, toothache, neurogenic pain, neuropathic pain, nerve inflammation, nerve damage, shingles, herniated disc, ligament rupture, diabetes, diabetes mellitus, hypoglycemia, uremia, hypothyroidism, liver failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, mitochondrial disorders, carpal tunnel syndrome, spinal Trauma, penetrating injury, contusion, fracture or bone dislocation, pressure involving the superficial peroneal nerve, pressure from a tumor, increased intraocular pressure, damage from chemical agents or chemotherapy, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral leukodystrophy, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal cord Muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, hereditary ataxia, noise-induced hearing loss, congenital hearing loss, age-related hearing loss, Creutzfeldt-Jakob disease, transmissible spongiform encephalopathy, dementia with Lewy bodies, frontotemporal dementia, amyloidosis, diabetic neuropathy, globoid cell leukodystrophy (Krabbe disease), Bassen-Kornzweig syndrome, transverse myelitis, motor neuron disease, spinocerebellar ataxia, pre-eclampsia, hereditary spastic paraplegia,Spastic paraplegia, familial spastic paraplegia, French colonial disease, Strampel-Lorraine disease, non-alcoholic steatohepatitis (NASH), adrenomyeloneuropathy, progressive supranuclear palsy (PSP), Friedreich's ataxia, spinal cord injury, acute optic neuropathy (AON), hereditary or idiopathic retinal conditions, Leber congenital amaurosis (LCA), Leber hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant Optic nerve atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedjer's optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, ethambutol exposure, cyanide exposure, traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, chronic traumatic encephalopathy (CTE), diabetes mellitus, hypoglycemia, baclofenac, Hassen-Kornzweig syndrome, uremia, hypothyroidism, liver failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiency, mitochondrial disorders, cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, non-arteritic anterior ischemic optic neuropathy, spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury The antisense oligonucleotide of embodiment 127, including head injury, exposure to percussive and / or explosive force, penetrating injury to the CNS, increased intraocular pressure, injury due to forces that deform, stretch, crush or thin axons, enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 129. An antisense oligonucleotide comprising a sequence having at least 80% identity to SEQ ID NO:8. 130. The antisense oligonucleotide of embodiment 129, comprising a sequence having at least 85% identity to SEQ ID NO:8. 131. The antisense oligonucleotide of embodiment 129 or 130, comprising a sequence having at least 90% identity to SEQ ID NO:8. 132. The antisense oligonucleotide of any one of embodiments 129-131, comprising SEQ ID NO: 8. 133. The antisense oligonucleotide according to any one of embodiments 129-132, wherein the antisense oligonucleotide comprises one or more modifications. 134. The antisense oligonucleotide of embodiment 133, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 135. A pharmaceutical composition comprising an antisense oligonucleotide according to any one of embodiments 129 to 134. 136. The pharmaceutical composition according to embodiment 135, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 137. An antisense oligonucleotide comprising a sequence having at least 80% identity to SEQ ID NO:9. 138. The antisense oligonucleotide of embodiment 137, comprising a sequence having at least 85% identity to SEQ ID NO:9. 139. The antisense oligonucleotide of embodiment 137 or 138, comprising a sequence having at least 90% identity to SEQ ID NO:9. 140. The antisense oligonucleotide according to any one of embodiments 137-139, comprising SEQ ID NO: 9. 141. The antisense oligonucleotide according to any one of embodiments 137-140, wherein the antisense oligonucleotide comprises one or more modifications. 142. The antisense oligonucleotide of embodiment 141, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 143. A pharmaceutical composition comprising an antisense oligonucleotide according to any one of embodiments 137 to 142. 144. The pharmaceutical composition according to embodiment 143, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 145. An antisense oligonucleotide comprising a sequence having at least 80% identity to SEQ ID NO: 13. 146. The antisense oligonucleotide of embodiment 145, comprising a sequence having at least 85% identity to SEQ ID NO: 13. 147. The antisense oligonucleotide according to embodiment 145 or 146, comprising a sequence having at least 90% identity to SEQ ID NO: 13. 148. The antisense oligonucleotide according to any one of embodiments 145 to 147, comprising SEQ ID NO: 13. 149. The antisense oligonucleotide according to any one of embodiments 145 to 148, wherein the antisense oligonucleotide comprises one or more modifications. 150. The antisense oligonucleotide of embodiment 149, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 151. A pharmaceutical composition comprising an antisense oligonucleotide according to any one of embodiments 145 to 150. 152. The pharmaceutical composition according to embodiment 151, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 153. An antisense oligonucleotide comprising a sequence having at least 80% identity to SEQ ID NO: 22. 154. The antisense oligonucleotide of embodiment 153, comprising a sequence having at least 85% identity to SEQ ID NO: 22. 155. The antisense oligonucleotide of embodiment 153 or 154, comprising a sequence having at least 90% identity to SEQ ID NO: 22. 156. The antisense oligonucleotide of any one of embodiments 153 to 155, comprising SEQ ID NO: 22. 157. The antisense oligonucleotide according to any one of embodiments 153 to 156, wherein the antisense oligonucleotide comprises one or more modifications. 158. The antisense oligonucleotide of embodiment 157, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 159. A pharmaceutical composition comprising an antisense oligonucleotide according to any one of embodiments 153 to 158. 160. The pharmaceutical composition according to embodiment 159, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 161. An antisense oligonucleotide comprising a sequence having at least 80% identity to SEQ ID NO: 38. 162. The antisense oligonucleotide of embodiment 161, comprising a sequence having at least 85% identity to SEQ ID NO: 38. 163. The antisense oligonucleotide of embodiment 161 or 162, comprising a sequence having at least 90% identity to SEQ ID NO: 38. 164. The antisense oligonucleotide according to any one of embodiments 161 to 163, comprising SEQ ID NO: 38. 165. The antisense oligonucleotide according to any one of embodiments 161-164, wherein the antisense oligonucleotide comprises one or more modifications. 166. The antisense oligonucleotide according to embodiment 165, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 167. A pharmaceutical composition comprising an antisense oligonucleotide according to any one of embodiments 161 to 166. 168. The pharmaceutical composition according to embodiment 167, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 169. An antisense oligonucleotide comprising a sequence having at least 80% identity to SEQ ID NO: 549. 170. The antisense oligonucleotide of embodiment 169, comprising a sequence having at least 85% identity to SEQ ID NO: 549. 171. The antisense oligonucleotide of embodiment 169 or 170, comprising a sequence having at least 90% identity to SEQ ID NO: 549. 172. The antisense oligonucleotide of any one of embodiments 169-171, comprising SEQ ID NO: 549. 173. The antisense oligonucleotide according to any one of embodiments 169-172, wherein the antisense oligonucleotide comprises one or more modifications. 174. The antisense oligonucleotide of embodiment 173, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 175. A pharmaceutical composition comprising the antisense oligonucleotide of any one of embodiments 169 to 174. 176. The pharmaceutical composition according to embodiment 175, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 177. A method for treating and / or preventing axonal degeneration in a subject, comprising: A method comprising administering to a subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1), wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO:8. 178. The method of embodiment 177, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO:8. 179. The method of embodiment 177 or 178, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO:8. 180. The method of any one of embodiments 177-179, wherein the antisense oligonucleotide comprises SEQ ID NO:8. 181. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO:8. 182. The method of embodiment 181, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO:8. 183. The method of embodiment 181 or 182, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO:8. 184. The method of any one of embodiments 181-183, wherein the antisense oligonucleotide comprises SEQ ID NO:8. 185. The method of any one of embodiments 177-184, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 186. The method of any one of embodiments 177-185, wherein the antisense oligonucleotide comprises one or more modifications. 187. The method of embodiment 186, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 188. The method of any one of embodiments 177-187, wherein administering an antisense oligonucleotide reduces the level of SARM1 mRNA in the subject. 189. The method of any one of embodiments 177-187, wherein the level of SARM1 protein in the subject is reduced by administering an antisense oligonucleotide. 190. The method of any one of embodiments 181-189, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 191. The method of any of embodiments 181-189, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 192. The method of embodiment 191, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 193. The method of embodiment 191, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. 194. The method of embodiment 192, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiency, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 195. The method of embodiment 192, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 196. The method of embodiment 192, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 197. The method of any one of embodiments 181-190, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 198. The method of embodiment 197, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or injury caused by a chemical agent or chemotherapy. 199. The method of embodiment 198, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 200. The method of embodiment 199, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 201. The method of embodiment 199, wherein the pressure injury comprises pressure involving the superficial peroneal nerve, pressure from a tumor, or elevated intraocular pressure. 202. The method of embodiment 198, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 203. The method of embodiment 202, wherein the epothilone is ixabepilone. 204. The method of embodiment 202, wherein the taxane is paclitaxel or docetaxel. 205. The method of embodiment 202, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 206. The method of embodiment 202, wherein the proteasome inhibitor is bortezomib. 207. The method of embodiment 202, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 208. The method of embodiment 202, wherein the auristatin is conjugated monomethyl auristatin E. 209. The method of any one of embodiments 181-190, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 210. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 209. The method of embodiment 209, comprising the treatment of a condition selected from the group consisting of neurodegenerative disorders, neurodegenerative disorders, neuropathies ... 211. The method of embodiment 209, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 212. The method of embodiment 211, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber congenital amaurosis (LCA), Leber hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 213. The method of embodiment 211, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 214. The method of embodiment 211, in some embodiments, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 215. The method of any one of embodiments 181-190, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 216. The method of embodiment 215, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 217. The method of embodiment 216, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 218. The method of embodiment 216, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush or thin axons. 219. The method of embodiment 216, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 220. The method of any one of embodiments 181-190, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 221. The method of any one of embodiments 177-220, wherein the subject is a human. 222. The method of any one of embodiments 177-221, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 223. The method of embodiment 222, wherein the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 224. The method of embodiment 223, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. 225. The method of embodiment 223, wherein engaging in one or more high-risk activities comprises participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing. 226. One or more biomarkers of neurodegeneration a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and a level of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 227. A method for treating and / or preventing axonal degeneration in a subject, comprising: A method comprising administering to a subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1), wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO:9. 228. The method of embodiment 227, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO:9. 229. The method of embodiment 227 or 228, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO:9. 230. The method of any one of embodiments 227-229, wherein the antisense oligonucleotide comprises SEQ ID NO: 9. 231. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO:9. 232. The method of embodiment 231, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO:9. 233. The method of embodiment 231 or 232, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO:9. 234. The method of any one of embodiments 231-233, wherein the antisense oligonucleotide comprises SEQ ID NO: 9. 235. The method of any one of embodiments 227-234, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 236. The method of any one of embodiments 227-235, wherein the antisense oligonucleotide comprises one or more modifications. 237. The method of embodiment 236, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 238. The method of any one of embodiments 227-237, wherein the level of SARM1 mRNA in the subject is reduced by administering an antisense oligonucleotide. 239. The method of any one of embodiments 227-237, wherein the level of SARM1 protein in the subject is reduced by administering an antisense oligonucleotide. 240. The method of any one of embodiments 231-239, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 241. The method of any of embodiments 231-239, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 242. The method of embodiment 241, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 243. The method of embodiment 241, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. 244. The method of embodiment 242, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiency, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 245. The method of embodiment 242, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 246. The method of embodiment 242, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 247. The method of any one of embodiments 231-240, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 248. The method according to embodiment 247, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or injury caused by a chemical agent or chemotherapy. 249. The method of embodiment 248, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 250. The method of embodiment 249, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 251. The method of embodiment 249, wherein the pressure injury comprises pressure involving the superficial peroneal nerve, pressure from a tumor, or elevated intraocular pressure. 252. The method of embodiment 248, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 253. The method of embodiment 252, wherein the epothilone is ixabepilone. 254. The method of embodiment 252, wherein the taxane is paclitaxel or docetaxel. 255. The method of embodiment 252, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 256. The method of embodiment 252, wherein the proteasome inhibitor is bortezomib. 257. The method of embodiment 252, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 258. The method of embodiment 252, wherein the auristatin is conjugated monomethyl auristatin E. 259. The method of any one of embodiments 231-240, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 260. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 260. The method of embodiment 259, comprising the treatment of any of the conditions listed in claim 259, including a neurodegenerative disorder, noise-induced hearing loss, congenital hearing loss, age-related hearing loss, Creutzfeldt-Jakob disease, transmissible spongiform encephalopathy, dementia with Lewy bodies, frontotemporal dementia, amyloidosis, diabetic neuropathy, globoid cell leukodystrophy (Krabbe disease), Bassen-Kornzweig syndrome, transverse myelitis, motor neuron disease, spinocerebellar ataxia, pre-eclampsia, hereditary spastic paraplegia, spastic paraplegia, familial spastic paraplegia, French colonial disease, Strampel-Lorraine disease, non-alcoholic steatohepatitis (NASH), adrenomyeloneuropathy, progressive supranuclear palsy (PSP), Friedreich's ataxia, or spinal cord injury. 261. The method of embodiment 259, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 262. The method of embodiment 261, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber congenital amaurosis (LCA), Leber hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 263. The method of embodiment 261, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 264. The method of embodiment 261, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 265. The method of any one of embodiments 231-240, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 266. The method of embodiment 215, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 267. The method of embodiment 266, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 268. The method of embodiment 266, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush or thin axons. 269. The method of embodiment 266, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 270. The method of any one of embodiments 231-240, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 271. The method of any one of embodiments 227-270, wherein the subject is a human. 272. The method of any one of embodiments 227-271, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 273. The method of embodiment 272, wherein the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 274. The method of embodiment 273, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. 275. The method of embodiment 273, wherein engaging in one or more high-risk activities comprises participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing. 276. One or more biomarkers of neurodegeneration: a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and a level of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 277. A method for treating and / or preventing axonal degeneration in a subject, comprising: A method comprising administering to a subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1), wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO: 13. 278. The method of embodiment 277, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 13. 279. The method of embodiment 277 or 278, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 13. 280. The method of any one of embodiments 277-279, wherein the antisense oligonucleotide comprises SEQ ID NO: 13. 281. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO:13. 282. The method of embodiment 281, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 13. 283. The method of embodiment 281 or 282, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 13. 284. The method of any one of embodiments 281 to 283, wherein the antisense oligonucleotide comprises SEQ ID NO: 13. 285. The method of any one of embodiments 277-284, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 286. The method of any one of embodiments 277-285, wherein the antisense oligonucleotide comprises one or more modifications. 287. The method of embodiment 286, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 288. The method of any one of embodiments 277-287, wherein administering an antisense oligonucleotide reduces the level of SARM1 mRNA in the subject. 289. The method of any one of embodiments 277-287, wherein the level of SARM1 protein in the subject is reduced by administering an antisense oligonucleotide. 290. The method of any one of embodiments 281-289, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 291. The method of any of embodiments 281-289, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 292. The method of embodiment 291, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 293. The method of embodiment 291, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. 294. The method of embodiment 292, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiency, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 295. The method of embodiment 292, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 296. The method of embodiment 292, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 297. The method of any one of embodiments 281-290, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 298. The method of embodiment 297, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or chemical or chemotherapeutic injury. 299. The method of embodiment 298, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 300. The method of embodiment 298, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 301. The method of embodiment 298, wherein the pressure injury comprises pressure involving the superficial peroneal nerve, pressure from a tumor, or elevated intraocular pressure. 302. The method of embodiment 298, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 303. The method of embodiment 302, wherein the epothilone is ixabepilone. 304. The method of embodiment 302, wherein the taxane is paclitaxel or docetaxel. 305. The method of embodiment 302, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 306. The method of embodiment 302, wherein the proteasome inhibitor is bortezomib. 307. The method of embodiment 302, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 308. The method of embodiment 302, wherein the auristatin is conjugated monomethyl auristatin E. 309. The method of any one of embodiments 281-290, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 310. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 309. The method of embodiment 309, comprising the treatment of a condition including a neurodegenerative disorder, ... 311. The method of embodiment 309, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 312. The method of embodiment 311, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber congenital amaurosis (LCA), Leber hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 313. The method of embodiment 311, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 314. The method of embodiment 311, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 315. The method of any one of embodiments 281-290, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 316. The method of embodiment 315, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 317. The method of embodiment 316, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 318. The method of embodiment 316, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush, or thin axons. 319. The method of embodiment 316, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 320. The method of any one of embodiments 281-290, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 321. The method of any one of embodiments 277-320, wherein the subject is a human. 322. The method of any one of embodiments 277-321, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 323. The method of embodiment 322, wherein the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 324. The method of embodiment 323, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. 325. The method of embodiment 323, wherein engaging in one or more high-risk activities includes participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing. 326. One or more biomarkers of neurodegeneration a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and levels of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 327. A method for treating and / or preventing axonal degeneration in a subject, comprising: A method comprising administering to a subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1), wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO: 22. 328. The method of embodiment 327, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 22. 329. The method of embodiment 327 or 328, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 22. 330. The method of any one of embodiments 327-329, wherein the antisense oligonucleotide comprises SEQ ID NO: 22. 331. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO:22. 332. The method of embodiment 331, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 22. 333. The method of embodiment 331 or 332, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 22. 334. The method of any one of embodiments 331 to 333, wherein the antisense oligonucleotide comprises SEQ ID NO: 22. 335. The method of any one of embodiments 327-334, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 336. The method of any one of embodiments 327-335, wherein the antisense oligonucleotide comprises one or more modifications. 337. The method of embodiment 336, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 338. The method of any one of embodiments 327-337, wherein administering an antisense oligonucleotide reduces the level of SARM1 mRNA in the subject. 339. The method of any one of embodiments 327-337, wherein the level of SARM1 protein in the subject is reduced by administering an antisense oligonucleotide. 340. The method of any one of embodiments 331-339, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 341. The method of any of embodiments 331-339, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 342. The method of embodiment 341, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 343. The method of embodiment 341, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. 344. The method of embodiment 342, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiency, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 345. The method of embodiment 342, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 346. The method of embodiment 342, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 347. The method of any one of embodiments 331-340, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 348. The method according to embodiment 347, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or injury caused by a chemical agent or chemotherapy. 349. The method of embodiment 348, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 350. The method of embodiment 348, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 351. The method of embodiment 348, wherein the pressure injury comprises pressure involving the superficial peroneal nerve, pressure from a tumor, or increased intraocular pressure. 352. The method of embodiment 348, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 353. The method of embodiment 352, wherein the epothilone is ixabepilone. 354. The method of embodiment 352, wherein the taxane is paclitaxel or docetaxel. 355. The method of embodiment 352, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 356. The method of embodiment 352, wherein the proteasome inhibitor is bortezomib. 357. The method of embodiment 352, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 358. The method of embodiment 352, wherein the auristatin is conjugated monomethyl auristatin E. 359. The method of any one of embodiments 331-340, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 360. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 360. The method of embodiment 359, comprising the treatment of a condition including a neurodegenerative disorder, ... 361. The method of embodiment 359, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 362. The method of embodiment 361, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber's congenital amaurosis (LCA), Leber's hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier's optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 363. The method of embodiment 361, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 364. The method of embodiment 361, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 365. The method of any one of embodiments 331-340, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 366. The method of embodiment 365, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 367. The method of embodiment 366, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 368. The method of embodiment 366, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush, or thin axons. 369. The method of embodiment 366, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 370. The method of any one of embodiments 331-340, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 371. The method of any one of embodiments 327-370, wherein the subject is a human. 372. The method of any one of embodiments 327-371, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 373. The method of embodiment 372, wherein the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 374. The method of embodiment 373, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. 375. The method of embodiment 373, wherein engaging in one or more high-risk activities comprises participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing. 376. One or more biomarkers of neurodegeneration, a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and levels of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 377. A method for treating and / or preventing axonal degeneration in a subject, comprising: A method comprising administering to a subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1), wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO: 38. 378. The method of embodiment 377, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 38. 379. The method of embodiment 377 or 378, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 38. 380. The method of any one of embodiments 377-379, wherein the antisense oligonucleotide comprises SEQ ID NO: 38. 381. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO:38. 382. The method of embodiment 381, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 38. 383. The method of embodiment 381 or 382, ​​wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 38. 384. The method of any one of embodiments 381 to 383, wherein the antisense oligonucleotide comprises SEQ ID NO: 38. 385. The method of any one of embodiments 377-384, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 386. The method of any one of embodiments 377-385, wherein the antisense oligonucleotide comprises one or more modifications. 387. The method of embodiment 386, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 388. The method of any one of embodiments 377-387, wherein administering an antisense oligonucleotide reduces the level of SARM1 mRNA in the subject. 389. The method of any one of embodiments 377-387, wherein the level of SARM1 protein in the subject is reduced by administering an antisense oligonucleotide. 390. The method of any one of embodiments 381-389, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 391. The method of any of embodiments 381-389, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 392. The method of embodiment 391, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 393. The method of embodiment 391, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. 394. The method of embodiment 392, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiency, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 395. The method of embodiment 392, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 396. The method of embodiment 392, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 397. The method of any one of embodiments 381-390, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 398. The method of embodiment 397, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or chemical or chemotherapeutic injury. 399. The method of embodiment 398, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 400. The method of embodiment 398, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 401. The method of embodiment 398, wherein the pressure injury comprises pressure involving the superficial peroneal nerve, pressure from a tumor, or increased intraocular pressure. 402. The method of embodiment 398, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 403. The method of embodiment 402, wherein the epothilone is ixabepilone. 404. The method of embodiment 402, wherein the taxane is paclitaxel or docetaxel. 405. The method of embodiment 402, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 406. The method of embodiment 402, wherein the proteasome inhibitor is bortezomib. 407. The method of embodiment 402, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 408. The method of embodiment 402, wherein the auristatin is conjugated monomethyl auristatin E. 409. The method of any one of embodiments 381-390, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 410. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 409. The method of embodiment 409, comprising the treatment of a condition characterized by a neurodegenerative disorder, including encephalopathy, noise-induced hearing loss, congenital hearing loss, age-related hearing loss, Creutzfeldt-Jakob disease, transmissible spongiform encephalopathy, dementia with Lewy bodies, frontotemporal dementia, amyloidosis, diabetic neuropathy, globoid cell leukodystrophy (Krabbe disease), Bassen-Kornzweig syndrome, transverse myelitis, motor neuron disease, spinocerebellar ataxia, pre-eclampsia, hereditary spastic paraplegia, spastic paraplegia, familial spastic paraplegia, French colonial disease, Strampel-Lorraine disease, non-alcoholic steatohepatitis (NASH), adrenomyeloneuropathy, progressive supranuclear palsy (PSP), Friedreich's ataxia, or spinal cord injury. 411. The method of embodiment 409, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 412. The method of embodiment 411, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber congenital amaurosis (LCA), Leber hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 413. The method of embodiment 411, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 414. The method of embodiment 411, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 415. The method of any one of embodiments 381-390, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 416. The method of embodiment 415, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 417. The method of embodiment 416, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 418. The method of embodiment 416, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush or thin axons. 419. The method of embodiment 416, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 420. The method of any one of embodiments 381-390, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 421. The method of any one of embodiments 377-420, wherein the subject is a human. 422. The method of any one of embodiments 377-421, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 423. The method of embodiment 422, wherein the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 424. The method of embodiment 423, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. 425. The method of embodiment 423, wherein engaging in one or more high-risk activities includes participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing. 426. One or more biomarkers of neurodegeneration a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and levels of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 427. A method for treating and / or preventing axonal degeneration in a subject, comprising: A method comprising administering to a subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1), wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO: 549. 428. The method of embodiment 427, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 549. 429. The method of embodiment 427 or 428, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 549. 430. The method of any one of embodiments 427-429, wherein the antisense oligonucleotide comprises SEQ ID NO: 549. 431. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO:549. 432. The method of embodiment 431, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 549. 433. The method of embodiment 431 or 432, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 549. 434. The method of any one of embodiments 431 to 433, wherein the antisense oligonucleotide comprises SEQ ID NO: 549. 435. The method of any one of embodiments 427-434, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 436. The method of any one of embodiments 427-425, wherein the antisense oligonucleotide comprises one or more modifications. 437. The method of embodiment 436, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 438. The method of any one of embodiments 427-437, wherein the level of SARM1 mRNA in the subject is reduced by administering an antisense oligonucleotide. 439. The method of any one of embodiments 427-437, wherein the level of SARM1 protein in the subject is reduced by administering an antisense oligonucleotide. 440. The method of any one of embodiments 431-439, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 441. The method of any of embodiments 431-439, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 442. The method of embodiment 441, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 443. The method of embodiment 441, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. 444. The method of embodiment 442, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiency, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 445. The method of embodiment 442, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 446. The method of embodiment 442, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 447. The method of any one of embodiments 431-440, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 448. The method of embodiment 447, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or injury caused by a chemical agent or chemotherapy. 449. The method of embodiment 448, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 450. The method of embodiment 448, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 451. The method of embodiment 448, wherein the pressure injury includes pressure involving the superficial peroneal nerve, pressure from a tumor, or increased intraocular pressure. 452. The method of embodiment 448, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 453. The method of embodiment 452, wherein the epothilone is ixabepilone. 454. The method of embodiment 452, wherein the taxane is paclitaxel or docetaxel. 455. The method of embodiment 452, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 456. The method of embodiment 452, wherein the proteasome inhibitor is bortezomib. 457. The method of embodiment 452, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 458. The method of embodiment 452, wherein the auristatin is conjugated monomethyl auristatin E. 459. The method of any one of embodiments 431-440, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 460. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler syndrome, progressive multifocal leukoencephalopathy, Alexander disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 460. The method of embodiment 459, comprising the treatment of a condition characterized by a neurodegenerative disorder, including encephalopathy, noise-induced hearing loss, congenital hearing loss, age-related hearing loss, Creutzfeldt-Jakob disease, transmissible spongiform encephalopathy, dementia with Lewy bodies, frontotemporal dementia, amyloidosis, diabetic neuropathy, globoid cell leukodystrophy (Krabbe disease), Bassen-Kornzweig syndrome, transverse myelitis, motor neuron disease, spinocerebellar ataxia, pre-eclampsia, hereditary spastic paraplegia, spastic paraplegia, familial spastic paraplegia, French colonial disease, Strampel-Lorraine disease, non-alcoholic steatohepatitis (NASH), adrenomyeloneuropathy, progressive supranuclear palsy (PSP), Friedreich's ataxia, or spinal cord injury. 461. The method of embodiment 459, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 462. The method of embodiment 461, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber congenital amaurosis (LCA), Leber hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 463. The method of embodiment 461, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 464. The method of embodiment 461, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 465. The method of any one of embodiments 431-440, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 466. The method of embodiment 465, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 467. The method of embodiment 465, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 468. The method of embodiment 465, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush, or thin axons. 469. The method of embodiment 465, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 470. The method of any one of embodiments 431-440, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 471. The method of any one of embodiments 427-470, wherein the subject is a human. 472. The method of any one of embodiments 427-471, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 473. The method of embodiment 472, wherein the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 474. The method of embodiment 473, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. 475. The method of embodiment 473, wherein engaging in one or more high-risk activities includes participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing. 476. One or more biomarkers of neurodegeneration a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and levels of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 477. An antisense oligonucleotide comprising a sequence having at least 80% identity to SEQ ID NO: 2410. 478. The antisense oligonucleotide of embodiment 477, comprising a sequence having at least 85% identity to SEQ ID NO: 2410. 479. The antisense oligonucleotide of embodiment 477 or 478, comprising a sequence having at least 90% identity to SEQ ID NO: 2410. 480. The antisense oligonucleotide of any one of embodiments 477-479, comprising SEQ ID NO: 2410. 481. The antisense oligonucleotide according to any one of embodiments 477-480, wherein the antisense oligonucleotide comprises one or more modifications. 482. The antisense oligonucleotide of embodiment 481, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 483. A pharmaceutical composition comprising the antisense oligonucleotide according to any one of embodiments 477-482. 484. The pharmaceutical composition according to embodiment 483, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 485. A method for treating and / or preventing axonal degeneration in a subject, comprising: A method comprising administering to a subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1). 486. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1. 487. The method of embodiment 485 or 486, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 488. The method of any one of embodiments 485 to 487, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO: 2410. 489. The method of any one of embodiments 485 to 488, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 2410. 490. The method of any one of embodiments 485 to 489, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 2410. 491. The method of any one of embodiments 485 to 490, wherein the antisense oligonucleotide comprises SEQ ID NO: 2410. 492. The method of any one of embodiments 485-491, wherein the antisense oligonucleotide comprises one or more modifications. 493. The method of embodiment 492, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 494. The method of any one of embodiments 485-493, wherein administering an antisense oligonucleotide reduces the level of SARM1 mRNA in the subject. 495. The method of any one of embodiments 485-493, wherein administering an antisense oligonucleotide reduces the level of SARM1 protein in the subject. 496. The method of any one of embodiments 486-495, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 497. The method of any of embodiments 486-495, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 498. The method of embodiment 497, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 499. The method of embodiment 497, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. 500. The method of embodiment 498, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiency, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 501. The method of embodiment 498, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 502. The method of embodiment 498, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 503. The method of any one of embodiments 486-496, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 504. The method of embodiment 503, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or injury caused by a chemical agent or chemotherapy. 505. The method of embodiment 504, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 506. The method of embodiment 505, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 507. The method of embodiment 505, wherein the pressure injury comprises pressure involving the superficial peroneal nerve, pressure from a tumor, or increased intraocular pressure. 508. The method of embodiment 504, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 509. The method of embodiment 508, wherein the epothilone is ixabepilone. 510. The method of embodiment 508, wherein the taxane is paclitaxel or docetaxel. 511. The method of embodiment 508, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 512. The method of embodiment 508, wherein the proteasome inhibitor is bortezomib. 513. The method of embodiment 508, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 514. The method of embodiment 508, wherein the auristatin is conjugated monomethyl auristatin E. 515. The method of any one of embodiments 486-496, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 516. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 516. The method of embodiment 515, comprising the treatment of a condition including a neurodegenerative disorder, ... 517. The method of embodiment 515, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 518. The method of embodiment 517, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber's congenital amaurosis (LCA), Leber's hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier's optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 519. The method of embodiment 517, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 520. The method of embodiment 517, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 521. The method of any one of embodiments 486-496, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 522. The method of embodiment 521, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 523. The method of embodiment 522, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 524. The method of embodiment 522, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush or thin axons. 525. The method of embodiment 522, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 526. The method of any one of embodiments 486-496, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 527. The method of any one of embodiments 485-526, wherein the subject is a human. 528. The method of any one of embodiments 485-527, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 529. The method of embodiment 528, wherein the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 530. The method of embodiment 529, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. 531. The method of embodiment 529, wherein engaging in one or more high-risk activities includes participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing. 532. One or more biomarkers of neurodegeneration are: a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and levels of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 533. An antisense oligonucleotide comprising a sequence having at least 80% identity to SEQ ID NO: 2411. 534. The antisense oligonucleotide of embodiment 533, comprising a sequence having at least 85% identity to SEQ ID NO: 2411. 535. The antisense oligonucleotide of embodiment 533 or 534, comprising a sequence having at least 90% identity to SEQ ID NO: 2411. 536. The antisense oligonucleotide of any one of embodiments 533 to 535, comprising SEQ ID NO: 2411. 537. The antisense oligonucleotide according to any one of embodiments 533-536, wherein the antisense oligonucleotide comprises one or more modifications. 538. The antisense oligonucleotide of embodiment 537, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 539. A pharmaceutical composition comprising the antisense oligonucleotide according to any one of embodiments 533-538. 540. The pharmaceutical composition according to embodiment 539, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 541. A method for treating and / or preventing axonal degeneration in a subject, comprising: A method comprising administering to a subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1). 542. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1. 543. The method of embodiment 541 or 542, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 544. The method of any one of embodiments 541 to 543, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO: 2411. 545. The method of any one of embodiments 541 to 544, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 2411. 546. The method of any one of embodiments 541 to 545, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 2411. 547. The method of any one of embodiments 541 to 546, wherein the antisense oligonucleotide comprises SEQ ID NO: 2411. 548. The method of any one of embodiments 541-547, wherein the antisense oligonucleotide comprises one or more modifications. 549. The method of embodiment 548, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 550. The method of any one of embodiments 541-549, wherein the level of SARM1 mRNA in the subject is reduced by administering an antisense oligonucleotide. 551. The method of any one of embodiments 541-549, wherein the level of SARM1 protein in the subject is reduced by administering an antisense oligonucleotide. 552. The method of any one of embodiments 542-551, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 553. The method of any of embodiments 542-551, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 554. The method of embodiment 553, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 555. The method of embodiment 553, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathies or other peripheral neuropathies. 556. The method of embodiment 554, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiency, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 557. The method of embodiment 554, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 558. The method of embodiment 554, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 559. The method of any one of embodiments 542-552, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 560. The method of embodiment 559, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or injury caused by a chemical agent or chemotherapy. 561. The method of embodiment 560, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 562. The method of embodiment 561, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 563. The method of embodiment 561, wherein the pressure injury comprises pressure involving the superficial peroneal nerve, pressure from a tumor, or increased intraocular pressure. 564. The method of embodiment 560, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 565. The method of embodiment 564, wherein the epothilone is ixabepilone. 566. The method of embodiment 564, wherein the taxane is paclitaxel or docetaxel. 567. The method of embodiment 564, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 568. The method of embodiment 564, wherein the proteasome inhibitor is bortezomib. 569. The method of embodiment 564, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 570. The method of embodiment 564, wherein the auristatin is conjugated monomethyl auristatin E. 571. The method of any one of embodiments 542-552, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 572. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 572. The method of embodiment 571, comprising the treatment of a condition including a neurodegenerative disorder, ... 573. The method of embodiment 571, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 574. The method of embodiment 573, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber's congenital amaurosis (LCA), Leber's hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier's optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 575. The method of embodiment 573, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 576. The method of embodiment 573, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 577. The method of any one of embodiments 542-552, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 578. The method of embodiment 577, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 579. The method of embodiment 578, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 580. The method of embodiment 578, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush, or thin axons. 581. The method of embodiment 578, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 581. The method of any one of embodiments 542-552, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 582. The method of any one of embodiments 541-581, wherein the subject is a human. 583. The method of any one of embodiments 541-582, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 584. The method of embodiment 583, wherein the one or more risk factors for developing a condition involving axonal degeneration comprise age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 585. The method of embodiment 584, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of an ApoE4 allele, or a combination thereof. 586. The method of embodiment 584, wherein engaging in one or more high-risk activities includes participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing. 587. One or more biomarkers of neurodegeneration a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and levels of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 588. An antisense oligonucleotide comprising a sequence having at least 80% identity to SEQ ID NO: 2412. 589. The antisense oligonucleotide of embodiment 588, comprising a sequence having at least 85% identity to SEQ ID NO: 2412. 590. The antisense oligonucleotide of embodiment 588 or 589, comprising a sequence having at least 90% identity to SEQ ID NO: 2412. 591. The antisense oligonucleotide of any one of embodiments 588 to 590, comprising SEQ ID NO: 2412. 592. The antisense oligonucleotide according to any one of embodiments 588-591, wherein the antisense oligonucleotide comprises one or more modifications. 593. The antisense oligonucleotide of embodiment 592, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 594. A pharmaceutical composition comprising the antisense oligonucleotide according to any one of embodiments 588-593. 595. The pharmaceutical composition according to embodiment 594, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier. 596. A method for treating and / or preventing axonal degeneration in a subject, comprising: A method comprising administering to a subject an antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1). 597. A method comprising administering to a subject at risk of developing a neurodegenerative disease or disorder an antisense oligonucleotide that is complementary to a target region of a nucleic acid encoding SARM1. 598. The method of embodiment 596 or 597, wherein the target nucleic acid encoding SARM1 is SARM1 mRNA. 599. The method of any one of embodiments 596 to 598, wherein the antisense oligonucleotide comprises a sequence having at least 80% identity to SEQ ID NO: 2412. 600. The method of any one of embodiments 596-599, wherein the antisense oligonucleotide comprises a sequence having at least 85% identity to SEQ ID NO: 2412. 601. The method of any one of embodiments 596-600, wherein the antisense oligonucleotide comprises a sequence having at least 90% identity to SEQ ID NO: 2412. 602. The method of any one of embodiments 596-601, wherein the antisense oligonucleotide comprises SEQ ID NO: 2412. 603. The method of any one of embodiments 596-602, wherein the antisense oligonucleotide comprises one or more modifications. 604. The method of embodiment 603, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof. 605. The method of any one of embodiments 596-604, wherein administering an antisense oligonucleotide reduces the level of SARM1 mRNA in the subject. 606. The method of any one of embodiments 596-604, wherein the level of SARM1 protein in the subject is reduced by administering an antisense oligonucleotide. 607. The method of any one of embodiments 597-606, wherein the neurodegenerative disease or disorder comprises an acute or chronic disease or disorder of the peripheral nervous system (PNS), an acute or chronic disease or disorder of the central nervous system (CNS), or a disease associated with neurodegeneration. 608. The method of any of embodiments 597-606, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the PNS. 609. The method of embodiment 608, wherein the chronic disease or disorder of the PNS comprises a systemic disorder, a pain disorder, or a metabolic disease or disorder. 610. The method of embodiment 608, wherein the chronic disease or disorder of the PNS comprises hereditary neuropathies, Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies (HSAN), chronic inflammatory demyelinating polyneuropathy (CIDP), idiopathic neuropathy or other peripheral neuropathies. 611. The method of embodiment 609, wherein the systemic disorder comprises diabetes, uremia, AIDS, leprosy, nutritional deficiency, atherosclerosis, enteric neuropathy, axonopathy, Guillain-Barré syndrome, severe acute motor axonal neuropathy (AMAN), systemic lupus erythematosus, scleroderma, sarcoidosis, rheumatoid arthritis, or polyarteritis nodosa. 612. The method of embodiment 609, wherein the pain disorder comprises chronic pain, fibromyalgia, spinal pain, carpal tunnel syndrome, cancer pain, arthritis, sciatica, headache, surgical pain, muscle spasm, back pain, visceral pain, injury pain, dental pain, neurogenic pain, neuropathic pain, nerve inflammation, nerve injury, shingles, herniated disc, torn ligament, or diabetes. 613. The method of embodiment 609, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), lipid / glycolipid metabolism disorders, nutritional deficiencies, vitamin deficiencies, or mitochondrial disorders. 614. The method of any one of embodiments 597-607, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the peripheral nervous system. 615. The method of embodiment 614, wherein the acute disease or disorder of the PNS is the result of mechanical injury, thermal injury, or injury caused by a chemical agent or chemotherapy. 616. The method of embodiment 615, wherein the mechanical injury comprises a compression or constriction injury or a pressure injury. 617. The method of embodiment 616, wherein the compression or constriction injury comprises carpal tunnel syndrome, direct trauma, penetrating injury, contusion, fracture, or bone dislocation. 618. The method of embodiment 616, wherein the pressure injury comprises pressure involving the superficial peroneal nerve, pressure from a tumor, or increased intraocular pressure. 619. The method of embodiment 615, wherein the chemical agent or chemotherapy comprises a cytotoxic anticancer drug, thalidomide, epothilone, taxane, vinca alkaloid, proteasome inhibitor, platinum-based drug or auristatin. 620. The method of embodiment 619, wherein the epothilone is ixabepilone. 621. The method of embodiment 619, wherein the taxane is paclitaxel or docetaxel. 622. The method of embodiment 619, wherein the vinca alkaloid is vinblastine, vinorelbine, vincristine, or vindesine. 623. The method of embodiment 619, wherein the proteasome inhibitor is bortezomib. 624. The method of embodiment 619, wherein the platinum-based agent is cisplatin, oxaliplatin, or carboplatin. 625. The method of embodiment 619, wherein the auristatin is conjugated monomethyl auristatin E. 626. The method of any one of embodiments 597-607, wherein the neurodegenerative disease or disorder comprises a chronic disease or disorder of the CNS. 627. Chronic diseases or disorders of the CNS include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), Huntington's disease (HD), senile dementia, Pick's disease, Gaucher's disease, Hurler's syndrome, progressive multifocal leukoencephalopathy, Alexander's disease, congenital cerebral hypomyelination, encephalomyelitis, acute disseminated encephalomyelitis, central pontine myelinolysis, osmotic hyponatremia, Tay-Sachs disease, motor neuron disease, ataxia, spinal muscular atrophy (SMA), Niemann-Pick disease, acute hemorrhagic leukoencephalitis, trigeminal neuralgia, Bell's palsy, cerebral ischemia, multiple system atrophy, Pelizaeus-Merzbach disease, periventricular leukomalacia, and hereditary ataxia. 627. The method of embodiment 626, comprising the treatment of a condition including a neurodegenerative disorder, including encephalopathy, noise-induced hearing loss, congenital hearing loss, age-related hearing loss, Creutzfeldt-Jakob disease, transmissible spongiform encephalopathy, dementia with Lewy bodies, frontotemporal dementia, amyloidosis, diabetic neuropathy, globoid cell leukodystrophy (Krabbe disease), Bassen-Kornzweig syndrome, transverse myelitis, motor neuron disease, spinocerebellar ataxia, pre-eclampsia, hereditary spastic paraplegia, spastic paraplegia, familial spastic paraplegia, French colonial disease, Strampel-Lorraine disease, non-alcoholic steatohepatitis (NASH), adrenomyeloneuropathy, progressive supranuclear palsy (PSP), Friedreich's ataxia, or spinal cord injury. 628. The method of embodiment 626, wherein the chronic disease or disorder of the CNS comprises optic neuropathy, traumatic CNS injury, or a metabolic disease or disorder. 629. The method of embodiment 628, wherein the optic neuropathy comprises acute optic neuropathy (AON), a hereditary or idiopathic retinal condition, Leber congenital amaurosis (LCA), Leber hereditary optic neuropathy (LHON), primary open-angle glaucoma (POAG), acute angle-closure glaucoma (AACG), autosomal dominant optic atrophy, retinal ganglion degeneration, retinitis pigmentosa, outer retinal neuropathy, optic neuritis, optic nerve degeneration associated with multiple sclerosis, Kedzier optic neuropathy, ischemic optic neuropathy, vitamin B12 deficiency, folate (vitamin B9) deficiency, isolated vitamin E deficiency syndrome, non-arteritic anterior ischemic optic neuropathy, exposure to ethambutol, or exposure to cyanide. 630. The method of embodiment 628, wherein the traumatic CNS injury comprises traumatic brain injury (TBI), spinal cord injury, traumatic axonal injury, or chronic traumatic encephalopathy (CTE). 631. The method of embodiment 628, wherein the metabolic disease or disorder comprises diabetes mellitus, hypoglycemia, Bassen-Kornzweig syndrome, uremia, hypothyroidism, hepatic failure, polycythemia, amyloidosis, acromegaly, porphyria, lipid / glycolipid metabolism disorders, nutritional / vitamin deficiencies, and mitochondrial disorders. 632. The method of any one of embodiments 597-607, wherein the neurodegenerative disease or disorder comprises an acute disease or disorder of the CNS. 633. The method of embodiment 632, wherein the acute disease or disorder of the CNS comprises ischemia, traumatic CNS injury, chemical injury, thermal injury, or viral encephalitis. 634. The method of embodiment 633, wherein the ischemia comprises cerebral ischemia, hypoxic demyelination, ischemic demyelination, ischemic optic neuropathy, or non-arteritic anterior ischemic optic neuropathy. 635. The method of embodiment 633, wherein the traumatic CNS injury comprises spinal cord injury, TBI, mechanical injury to the head and / or spine, traumatic injury to the head and / or spine, blunt trauma, closed head injury, open head injury, exposure to percussive and / or explosive forces, penetrating injury to the CNS, increased intraocular pressure, or injury due to forces that deform, stretch, crush, or thin axons. 636. The method of embodiment 633, wherein the viral encephalitis comprises enteroviral encephalitis, arboviral encephalitis, herpes simplex virus (HSV) encephalitis, West Nile virus encephalitis, La Crosse encephalitis, Bunyaviral encephalitis, pediatric viral encephalitis, or HIV encephalopathy (HIV-associated dementia). 637. The method of any one of embodiments 597-6070, wherein the neurodegenerative disease or disorder results from blood clotting problems, inflammation, obesity, aging, stress, cancer, or diabetes. 638. The method of any one of embodiments 596-637, wherein the subject is a human. 639. The method of any one of embodiments 596-638, wherein the subject is a patient with one or more risk factors for developing a condition involving axonal degeneration. 640. The method of embodiment 639, wherein the one or more risk factors for developing a condition involving axonal degeneration include age, one or more genetic risk factors for neurodegeneration, family history, engaging in one or more high-risk activities, one or more biomarkers of neurodegeneration, or a combination thereof. 641. The method of embodiment 640, wherein the one or more genetic risk factors for neurodegeneration comprise one or more copies of a known genetic risk factor, a hexanucleotide repeat expansion in chromosome 9 open reading frame 72, one or more copies of the ApoE4 allele, or a combination thereof. 642. The method of embodiment 640, wherein engaging in one or more high-risk activities includes participating in activities including American football, basketball, boxing, diving, field hockey, soccer, ice hockey, lacrosse, martial arts, rodeo, rugby, ski jumping, water polo, wrestling, baseball, cycling, cheerleading, fencing, track and field, gymnastics, handball, horseback riding, skating, skiing, skateboarding, softball, squash, ultimate frisbee, volleyball, and / or windsurfing. 643. One or more biomarkers of neurodegeneration a concentration of neurofilament light chain protein (NF-L) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of neurofilament heavy chain protein (NF-H) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of ubiquitin C-terminal hydrolase L1 (UCH-L1) in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; a concentration of alpha synuclein in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, and a plasma sample from the subject; constitutive NAD+ levels in neurons and / or axons of the subject; Constitutive cADPR levels in neurons and / or axons of interest; levels of albumin, amyloid-β (Aβ)38, Aβ40, Aβ42, glial fibrillary acidic protein (GFAP), heart-type fatty acid binding protein (hFABP), monocyte chemoattractant protein (MCP)-1, neurogranin, neuron-specific enolase (NSE), soluble amyloid precursor protein (sAPP)α, sAPPβ, soluble triggering receptor expressed on myeloid cells (sTREM)2, phosphotau, or total tau in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject; and determining levels of CC Motif Chemokine Ligand (CCL)2, CCL7, CCL12, colony-stimulating factor (CSF) 1, or interleukin (IL)6 in one or more of a cerebrospinal fluid (CSF) sample, a blood sample, a plasma sample, a skin biopsy sample, a nerve biopsy sample, and a brain biopsy sample from the subject. 644. The antisense oligonucleotide, pharmaceutical composition, or method of any one of embodiments 1 to 643, wherein the antisense oligonucleotide is complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1). 645.Antisense oligonucleotides are pattern R S R O R S R O R S D S D S D S D S D S D S D S D S D S D S R O R S R O R S containing an internucleotide bond of R S is RNA (2'-MOE) phosphorothioate linkage, and R O is an RNA (2'-MOE) phosphodiester bond, and D S The antisense oligonucleotide, pharmaceutical composition, or method of any one of embodiments 1-644, wherein is a DNA phosphorothioate bond. [Example]

[0134] The present teachings, including the descriptions provided by the examples, are not intended to limit the scope of the claims. Unless specifically presented in the past tense, the inclusion of an example does not imply that the experiment was actually performed. The following non-limiting examples are provided to further illustrate the present teachings. In light of the present disclosure, those skilled in the art will understand that many changes can be made in the specific embodiments disclosed and still obtain the same or similar results without departing from the spirit and scope of the present teachings.

[0135] Example 1: Antisense regulation of SARM1 transcripts in human neuroblastoma cell lines This example demonstrates an in vitro assay used to characterize oligonucleotides. Antisense oligonucleotides complementary to different regions of the SARM1 transcript were synthesized and tested for their ability to inhibit SARM1 transcript in vitro in human neuroblastoma cell lines.

[0136] Human neuroblastoma cell lines Human neuroblastoma cell line SH-SY5Y (ATCC-CRL-2266) was cultured in DMEM medium (Sigma-Aldrich) supplemented with 10% fetal bovine serum (Gibco) and 1 mM penicillin-streptomycin (Sigma). Cultures were plated at a density of 100,000 cells / well on 24-well tissue culture plates coated with poly-D-lysine (0.1 mg / mL, Sigma) and laminin (3 mg / mL, Invitrogen). Cells were allowed to adhere to the plates in a humidified tissue culture incubator (5% CO2). At 70% confluence, cells were transfected with antisense oligonucleotides containing sequences selected from SEQ ID NOs: 3-26 at final concentrations of 10-500 nM using Lipofectamine RNAiMAX diluted in Opti-MEM (ThermoFisher). The antisense oligonucleotides contained non-complementary 5-mer sequences 5' and 3' of a nucleotide sequence selected from SEQ ID NOs: 3-26, and internucleotide linkages of the following pattern (5' to 3'): S R O R S R O R S D S D S D S D S D S D S D S D S D S D S R O R S R O R S , where R S is RNA (2'-MOE) phosphorothioate linkage, and RO is an RNA (2'-MOE) phosphodiester bond, and D S is a DNA phosphorothioate bond. SARM1 siRNA (20 nM, Dharmacon) was used as a positive control. All conditions were performed in triplicate. Transfected cells were incubated for 24–72 h and harvested for RNA analysis. SARM1 transcript levels were assessed using quantitative PCR performed with a TaqMan Real-Time PCR system (Thermo Fisher). SARM1 RNA levels were normalized to GAPDH (delta Ct) and plate-matched control transfected samples (delta-delta Ct) to generate fold changes relative to the control quantification (2 − (delta-delta Ct)).

[0137] result The average fold change in control-transfected cells is plotted in Figure 2 , and a summary of the overall knockdown rate of SARM1 transcripts is shown in Table 2 . [Table 2]

[0138] Specifically, SEQ ID NO: 5 targeted the 5'UTR region, SEQ ID NOs: 4, 17, 18, 20, and 26 targeted the coding region, and SEQ ID NOs: 13, 14, 16, and 19 targeted the 3'UTR. Surprisingly, some antisense oligonucleotide (ASO) sequences targeting different regions of the SARM1 transcript resulted in strong knockdown of SARM1 expression compared to controls, while other ASO sequences had little or no effect. Taken together, these results confirm that measurable knockdown of SARM1 transcripts can be achieved by antisense targeting specific regions of the SARM1 mRNA sequence.

[0139] Example 2: Antisense regulation of SARM1 transcripts in human neuroblastoma cell lines This example demonstrates an in vitro assay used to characterize oligonucleotides. Antisense oligonucleotides complementary to different regions of the SARM1 transcript were synthesized and tested for their ability to inhibit SARM1 transcript in vitro in human neuroblastoma cell lines.

[0140] Human neuroblastoma cell lines Human neuroblastoma cell line SH-SY5Y (ATCC-CRL-2266) was cultured in DMEM medium (Sigma-Aldrich) supplemented with 10% fetal bovine serum (Gibco) and 1 mM penicillin-streptomycin (Sigma). Cultures were plated at a density of 100,000 cells / well on 24-well tissue culture plates coated with poly-D-lysine (0.1 mg / mL, Sigma) and laminin (3 mg / mL, Invitrogen). Cells were allowed to adhere to the plates in a humidified tissue culture incubator (5% CO2). Antisense oligonucleotides selected from SEQ ID NOs: 3-26 were transfected at 70% confluence at final concentrations of 10-500 nM using Lipofectamine RNAiMAX diluted in Opti-MEM (ThermoFisher). The antisense oligonucleotides contained the following internucleotide linkage pattern (5' to 3'): R S R O R S R O R S D S D S D S D S D S D S D S D S D S D S R O R S R O R S , where R S is RNA (2'-MOE) phosphorothioate linkage, and R O is an RNA (2'-MOE) phosphodiester bond, and D Sis a DNA phosphorothioate bond. SARM1 siRNA (20 nM, Dharmacon) was used as a positive control. All conditions were performed in triplicate. Transfected cells were incubated for 24–72 h and harvested for RNA analysis. SARM1 transcript levels were assessed using quantitative PCR performed with a TaqMan Real-Time PCR system (Thermo Fisher). SARM1 RNA levels were normalized to GAPDH (delta Ct) and plate-matched control transfected samples (delta-delta Ct) to generate fold changes relative to the control quantification (2 − (delta-delta Ct)).

[0141] result The average fold change relative to control-transfected cells is plotted in Figure 3. Specifically, SEQ ID NO: 5 targeted the 5'UTR region, SEQ ID NOs: 4, 17, 18, 20, and 26 targeted the coding region, and SEQ ID NOs: 13, 14, 16, and 19 targeted the 3'UTR. Surprisingly, several antisense oligonucleotide (ASO) sequences targeting different regions of the SARM1 transcript resulted in potent knockdown of SARM1 expression compared to the control, while other ASO sequences had little or no effect. Taken together, these results confirm that measurable knockdown of SARM1 transcripts can be achieved by antisense targeting specific regions of the SARM1 mRNA sequence.

[0142] Example 3: Antisense regulation of SARM1 transcripts in human motor neurons This example demonstrates potent, concentration-dependent knockdown of SARM1 gene expression levels in vitro in human induced pluripotent stem cell (IPSC)-derived motor neurons after transfection with antisense oligonucleotides targeting the SARM1 transcript.

[0143] Human iPSC-derived motor neurons (Cellular Dynamics-R1049) were cultured and maintained for 14 days using iCell Complete Maintenance Medium and DAPT (Cellular Dynamics) according to the manufacturer's instructions. Dissociated motor neuron cultures were generated by seeding 80,000 cells / well onto 24-well tissue culture plates coated with poly-D-lysine (0.1 mg / mL, Sigma) and laminin (3 mg / mL, Invitrogen). Cells were transfected with 0.1, 0.3, 1, 3, or 10 nM of antisense oligonucleotides containing SEQ ID NOs: 9, 13, 22, or 38 using Lipofectamine RNAiMAX diluted in Opti-MEM (ThermoFisher). The antisense oligonucleotides contained the following internucleotide linkage pattern (5' to 3'): R S R O R S R O R S D S D S D S D S D S D S D S D S D S D S R O R S R O R S , where R S is RNA (2'-MOE) phosphorothioate linkage, and R O is an RNA (2'-MOE) phosphodiester bond, and D Sis a DNA phosphorothioate bond. After 24 hours, three-quarters of the medium was changed to wash away the transfection solution. After 48 hours, cells were harvested and lysed for TaqMan RT-PCR analysis of SARM1 gene expression levels, normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene expression levels. The results are shown in Figure 4; data (n = 3) are expressed as mean ± SEM and normalized to control-treated cells. Figure 4 demonstrates that for all four antisense oligonucleotides, SARM1 expression in IPSC-derived motor neurons decreased with increasing concentration.

[0144] Example 4: Antisense regulation of SARM1 transcripts in human motor neurons after free uptake delivery This example demonstrates potent, concentration-dependent knockdown of SARM1 gene expression levels in vitro in human induced pluripotent stem cell (IPSC)-derived motor neurons after delivery by free uptake (i.e., in the absence of a lipid carrier) with antisense oligonucleotides targeting the SARM1 transcript.

[0145] Human iPSC-derived motor neurons (Cellular Dynamics-R1049) were cultured and maintained for 14 days using iCell Complete Maintenance Medium and DAPT (Cellular Dynamics) according to the manufacturer's instructions. Motor neuron cultures were created by seeding 10,000 cells / well onto 96-well tissue culture plates coated with poly-D-lysine (0.1 mg / mL, Sigma) and laminin (3 mg / mL, Invitrogen). After allowing the cells to adhere to the plates in a humidified tissue culture incubator (5% CO), the tissue culture wells were filled with 1 mL of cell culture medium. Antisense oligonucleotides containing SEQ ID NOs: 9, 13, or 38 were diluted in Opti-MEM (ThermoFisher) at concentrations ranging from 1.25 to 10 μM and added to the cell culture medium. The antisense oligonucleotides contained the following internucleotide linkage pattern (5' to 3'): R S R O R S R O R S D S D S D S D S D S D S D S D S D S D S R O R S R O R S , where R S is RNA (2'-MOE) phosphorothioate linkage, and R O is an RNA (2'-MOE) phosphodiester bond, and D Sis a DNA phosphorothioate bond. After 9 days, cells were harvested and lysed for TaqMan RT-PCR analysis of SARM1 gene expression levels, normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene expression levels. The results are shown in Figure 5, where data (n = 2) are expressed as mean ± SEM and normalized to control-treated cells. Figure 5 demonstrates that for all three antisense oligonucleotides, the expression of SARM1 in IPSC-derived motor neurons decreased with increasing concentration.

[0146] Example 5: Time-dependent antisense regulation of SARM1 transcripts in human motor neurons after free uptake delivery This example demonstrates the time-dependent knockdown of SARM1 gene expression levels in vitro in human induced pluripotent stem cell (IPSC)-derived motor neurons after free uptake (no lipid carrier) delivery of antisense oligonucleotides targeting the SARM1 transcript.

[0147] Human iPSC-derived motor neurons (Cellular Dynamics-R1049) were cultured and maintained for 14 days using iCell Complete Maintenance Medium and DAPT (Cellular Dynamics) according to the manufacturer's instructions. Motor neuron cultures were created by seeding 80,000 cells / well into each 24-well tissue culture plate coated with poly-D-lysine (0.1 mg / mL, Sigma) and laminin (3 mg / mL, Invitrogen). After allowing the cells to adhere to the plate in a humidified tissue culture incubator (5% CO2), the tissue culture wells were filled with 1 mL of cell culture medium. Antisense oligonucleotides containing SEQ ID NOs: 8, 9, 13, 22, or 38 were diluted to a concentration of 10 μM in Opti-MEM (ThermoFisher) and added to cell culture medium for free uptake delivery. The antisense oligonucleotides contained the following pattern (5' to 3') of internucleotide linkages: R S RO R S R O R S D S D S D S D S D S D S D S D S D S D S R O R S R O R S , where R S is RNA (2'-MOE) phosphorothioate linkage, and R O is an RNA (2'-MOE) phosphodiester bond, and D S is a DNA phosphorothioate bond. After 2 or 6 days, cells were harvested and lysed for TaqMan RT-PCR analysis of SARM1 gene expression levels, normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene expression levels. The results are shown in Figure 6, where data (n = 3) are expressed as mean ± SEM and normalized to control-treated cells. Figure 6 shows that for motor neurons treated with any of the five antisense oligonucleotides, SARM1 expression was reduced at both time points compared to untreated controls.

[0148] Example 6: SARM1 antisense prevents axonal degeneration after axotomy in human iPSC-derived motor neurons This example demonstrates that treatment with SARM1 antisense oligonucleotides prevented axon degeneration after axotomy. Specifically, using an in vitro axon degeneration assay, we tested the efficacy of oligonucleotides complementary to different regions of the SARM1 transcript to prevent axon degeneration in human induced pluripotent stem cell (iPSC)-derived motor neuron drop cultures.

[0149] Human motor neuron drop culture Human iPSC-derived motor neurons (Cellular Dynamics-R1049) were cultured and maintained for 14 days using iCell Complete Maintenance Medium and DAPT (Cellular Dynamics) according to the manufacturer's instructions. Motor neuron cultures were created by seeding 10,000 cells / well into each 24-well tissue culture plate coated with poly-D-lysine (0.1 mg / mL, Sigma) and laminin (3 mg / mL, Invitrogen). After allowing the cells to adhere to the plate in a humidified tissue culture incubator (5% CO2), the tissue culture wells were filled with 1 mL of cell culture medium. Antisense oligonucleotides containing SEQ ID NOs: 9, 22, 38, or 39 were diluted to a concentration of 5 μM in Opti-MEM (ThermoFisher) and added to cell culture medium for free uptake delivery. The antisense oligonucleotides contained the following internucleotide linkage pattern (5' to 3'): R S R O R S R O R S D S D S D S D S D S D S D S D S D S D S R O R S R O R S , where R S is RNA (2'-MOE) phosphorothioate linkage, and R O is an RNA (2'-MOE) phosphodiester bond, and D S indicates DNA phosphorothioate bond. Ten days after transfection, axon degeneration assay was performed.

[0150] Axon degeneration assay Axon degeneration was stimulated by manual axonal transection using a scalpel blade. After 16 hours, motor neuron cultures were fixed in 1% PFA and sucrose and stored in a refrigerator before imaging. Cells were immunostained for beta-3 tubulin (Clone TuJ1, R&D systems). Images of neuronal axons and somata were collected using a 20x water-immersion lens on a Phenix automated confocal microscope (PerkinElmer). Axonal quantification was performed using an in-house developed script (Acapella, PerkinElmer). The degeneration index reflects axonal integrity; higher values ​​indicate higher levels of axonal fragmentation, while lower values ​​indicate lower levels of axonal fragmentation. As shown in Figure 7, ASOs that knock down SARM1 expression reduced axonal degeneration in this assay. Data in Figure 7 are presented as mean ± SEM (n = 3-4). The dashed line labeled "cut" indicates the average level of degeneration observed in control cut axons, and the dashed line labeled "uncut" indicates the average level of degeneration observed in intact control axons.

[0151] Exemplary Sequences Wild-type human SARM1 protein sequence (SEQ ID NO: 1).

[0152] Wild-type human SARM1 cDNA sequence (corresponding to the mRNA sequence) (NCBI accession number: NM_15077.4). Exemplary ASO target sequences are shown in bold capital letters, with overlapping sequences underlined. In one example of overlapping ASO targeting, the sequence is shown in both bold and underlined capital letters. [Sequence Table 1-1] TIFF0007796797000003.tif147151 [Sequence Table 1-2] TIFF0007796797000004.tif252155 [Sequence Tables 1-3] TIFF0007796797000005.tif251154 [Sequence Tables 1-4] TIFF0007796797000006.tif113165 [Table 3-1] [Table 3-2] [Table 3-3] [Table 3-4] [Table 3-5] [Table 3-6] [Table 3-7] [Table 3-8] [Table 3-9] [Table 3-10] [Table 3-11] [Table 3-12] [Table 3-13] [Table 3-14] [Table 3-15] Table 3-16 Table 3-17 Table 3-18 Table 3-19 Table 3-20 Table 3-21 Table 3-22 Table 3-23 Table 3-24 Table 3-25 Table 3-26 Table 3-27 Table 3-28 Table 3-29 Table 3-30 Table 3-31 Table 3-32 Table 3-33 Table 3-34 Table 3-35 Table 3-36 Table 3-37 Table 3-38 Table 3-39 Table 3-40 Table 3-41 Table 3-42 Table 3-43 Table 3-44 Table 3-45 Table 3-46 Table 3-47 Table 3-48 Table 3-49 [Table 3-50] [Table 3-51] [Table 3-52] [Table 3-53] [Table 3-54] [Table 3-55] [Table 3-56] [Table 3-57] [Table 3-58] [Table 3-59] [Table 3-60] [Table 3-61] [Table 3-62]

[0153] equivalent While the present invention has been described in conjunction with a detailed description of the invention for carrying out the invention, it is to be understood that the above description is intended to illustrate, but not to limit, the scope of the invention as defined by the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.

[0154] The sequence listing accompanying this filing identifies each sequence as "RNA" or "DNA" where appropriate, although in practice these sequences can be modified with any combination of chemical modifications. Those of skill in the art will readily understand that designations such as "RNA" or "DNA" to describe modified oligonucleotides are, in some cases, arbitrary. For example, an oligonucleotide containing a nucleoside containing a 2'-OH sugar moiety and a thymine base may be described as a DNA with a modified sugar (2'-OH for the natural 2'-H in DNA) or an RNA with a modified base (thymine (methylated uracil) for the natural uracil in RNA).

[0155] Thus, the nucleic acid sequences provided herein, including but not limited to those in the Sequence Listing, are intended to encompass nucleic acids containing any combination of natural or modified RNA and / or DNA, including but not limited to such nucleic acids with modified nucleobases. By way of further example and without limitation, an oligomeric compound having the nucleobase sequence "ATCGATCG" is intended to encompass such compounds containing RNA bases, whether modified or not, e.g., those having the sequence "AUCGAUCG" and some DNA bases, as well as oligomeric compounds having some RNA bases, e.g., "AUCGATCG" and other modified or naturally occurring bases, e.g., "AT me CGAUCG" where: me C denotes a cytosine base containing a methyl group at the 5-position.

Claims

1. An antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1), comprising the sequence of SEQ ID NO:

22.

2. An antisense oligonucleotide complementary to a target region of a nucleic acid encoding sterile alpha and TIR motif-containing 1 (SARM1), comprising a sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 9, 13, and 38, wherein the antisense oligonucleotide inhibits expression of SARM1, and comprising a sequence selected from the group consisting of SEQ ID NOs: 2410-2412.

3. The antisense oligonucleotide of claim 1 or 2, wherein the antisense oligonucleotide comprises one or more modifications.

4. 4. The antisense oligonucleotide of claim 3, wherein the one or more modifications comprise a methylphosphonothioate internucleotide linkage, a phosphorothioate internucleotide linkage, a methylphosphonate internucleotide linkage, a phosphoramidate internucleotide linkage, a 3' end cap, a 3' hairpin loop structure, or a combination thereof.

5. The antisense oligonucleotide has pattern R Ｓ R Ｏ R Ｓ R Ｏ R Ｓ D Ｓ D Ｓ D Ｓ D Ｓ D Ｓ D Ｓ D Ｓ D Ｓ D Ｓ D Ｓ R Ｏ R Ｓ R Ｏ R Ｓ and R Ｓ is an RNA phosphorothioate bond, and R Ｏ is an RNA phosphodiester bond, and D Ｓ The antisense oligonucleotide according to claim 3 or 4, wherein is a DNA phosphorothioate bond.

6. A pharmaceutical composition comprising the antisense oligonucleotide of any one of claims 1 to 5 and a pharmaceutically acceptable diluent or carrier.

7. The pharmaceutical composition according to claim 6 for treating and / or preventing axonal degeneration in a subject.

8. 10. The pharmaceutical composition of claim 6 for treating a subject at risk of developing a neurodegenerative disease or disorder.

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