Ervatamia divaricata extract, preparation method thereof and application of ervatamia divaricata extract in resisting brain metastatic tumor
By extracting the monoterpenoid indole alkaloid compound GYH90MT from *Cynodon dactylon*, the problem of existing drugs being unable to cross the blood-brain barrier has been solved, enabling effective treatment of brain metastases from breast cancer.
CN121378211APending Publication Date: 2026-01-23CHINESE MEDICINE GUANGDONG LABORATORY +1
Patent Information
- Application Number
- CN202511653866.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-11
- Publication Date
- 2026-01-23
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Figure CN121378211A_ABST
Abstract
The invention provides an ervatamia divaricata extract as well as a preparation method and application of the ervatamia divaricata extract in resisting brain metastatic tumor. Pharmacological activity shows that the extract of ervatamia divaricata disclosed by the invention has remarkable cytotoxicity inhibition activity, and the inhibition effect of the extract is time-dependent and dose-dependent. The extract can inhibit the growth of breast cancer 4T1 brain metastases, and has no obvious adverse reaction on mice.
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