Vitamin B2-containing oral liquid composition

Abstract

To provide an oral liquid composition containing galangal extract and a vitamin B2, the composition showing a reduction in unpleasant odor.SOLUTION: An oral liquid composition contains A) galangal extract, B) a vitamin B2, and C) caffeine and / or arginine.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral liquid composition containing galangal extract, and more particularly to an oral liquid composition that suppresses the unpleasant odor characteristic of compositions containing galangal extract and vitamin B2. [Background technology]

[0002] In recent years, there has been an increasing demand for energy drinks intended to boost mood and refresh people. These energy drinks often contain vitamins such as vitamin B1, vitamin B2, vitamin B12, and ascorbic acid. They also typically contain caffeine, which stimulates the central nervous system and has a stimulating effect. Some consumers choose energy drinks with a high caffeine content in order to achieve a stronger sense of alertness.

[0003] In addition, food materials that have stimulating effects similar to caffeine are being developed. One such material is the rhizome of galangal (Alpinia galanga L.), a plant of the Zingiberaceae family that has been shown to enhance attention and alertness, and is attracting attention (Non-Patent Document 1). However, although there are beverages containing galangal, such as Organics by RedBull Simply Cola (Red Bull Japan) and XS Energy Coffee (Amway Japan), the number of such beverages is limited. [Prior art documents] [Non-patent literature]

[0004] [Non-Patent Document 1] Shalini, S. et al. (2017) Journal of the American College of Nutrition, 36(8), 631-639. Summary of the Invention [Problem to be solved by the invention]

[0005] In light of the above background, the inventors have newly discovered that blending vitamin B2 or a derivative thereof or a salt thereof (hereinafter also referred to as "vitamin B2 type") with galangal produces a unique unpleasant odor. Therefore, the present invention provides an oral liquid composition containing galangal extract and vitamin B2, which has a reduced unpleasant odor characteristic to the composition. [Means for solving the problem]

[0006] As a result of extensive research to solve the above-mentioned problems, the present inventors have found that in a composition containing an extract of the rhizome of galangal (Alpinia galanga L.), a plant of the Zingiberaceae family, and vitamin B2, the unpleasant odor characteristic of containing galangal extract and vitamin B2 can be reduced by adding caffeine and / or arginine.

[0007] That is, the present invention is as follows. (1) An oral liquid composition comprising A) a galangal extract, B) a vitamin B2 compound, and C) caffeine and / or arginine; (2) A) The oral liquid composition according to (1), wherein the concentration of the galangal extract is 0.001 to 10% by mass in terms of dry solid content. (3) B) The oral liquid composition according to (1) or (2), wherein the concentration of vitamin B2 is 0.0001 to 0.1% by mass. (4) C) The oral liquid composition according to any one of (1) to (3), wherein the concentration of caffeine is 0.001 to 1% by mass. (5) C) The oral liquid composition according to any one of (1) to (4), wherein the arginine concentration is 0.01 to 20% by mass. (6) The oral liquid composition according to any one of (1) to (5), having a pH of 2.0 to 7.0. (7) The oral liquid composition according to any one of (1) to (6), wherein the oral liquid composition is a liquid beverage. (8) A method for suppressing unpleasant odors in a liquid composition containing galangal extract and vitamin B2 by adding caffeine and / or arginine. [Effects of the Invention]

[0008] According to the present invention, it is possible to provide an oral liquid composition containing galangal extract and vitamin B2, in which the unpleasant odor characteristic of the oral liquid composition is reduced. DETAILED DESCRIPTION OF THE INVENTION

[0009] The galangal extract of the present invention is obtained by extracting the rhizome of galangal (Alpinia galanga L.), a plant of the genus Alpinia in the Zingiberaceae family, either directly or after drying, crushing, pulverizing, etc., as necessary. That is, the galangal extract of the present invention is an extract of the rhizome of galangal. Note that galangal is different from black ginger, a plant of the genus Bangia in the Zingiberaceae family, and turmeric, a plant of the genus Curcuma in the Zingiberaceae family.

[0010] The extraction method is not particularly limited, and may be performed by known extraction methods such as stirring, shaking, or immersion extraction using an organic solvent such as ethanol, water, or a mixture thereof, or reduced-pressure steam distillation extraction. If necessary, insoluble matter may be removed by centrifugation, enzyme treatment (treatment with an enzyme agent derived from Aspergillus oryzae, Aspergillus niger, etc.), column or filtration (filtration through a strainer mesh or membrane filter, etc.). The galangal extract of the present invention preferably uses water and / or alcohol as the extraction solvent, more preferably ethanol as the alcohol, and particularly preferably water alone. The extract obtained by the above-mentioned extraction may be used in liquid form, or may be dried into powder form and used. It may also be used in the form of a commercially available powder product (e.g., enXtra from Enovate Biolife). TM etc.) may also be used.

[0011] The content of the galangal extract in the oral liquid composition of the present invention, in terms of the dry solid content of the galangal extract, is preferably 0.001 to 10% by mass, more preferably 0.01 to 5% by mass, even more preferably 0.02 to 1% by mass, even more preferably 0.05 to 0.5% by mass, and particularly preferably 0.06 to 0.3% by mass. Here, "dry solids content" refers to the amount converted into the amount excluding water. Water content can be measured using a conventional heat drying method, Karl Fischer method, or the like.

[0012] Furthermore, the content of the galangal extract in the oral liquid composition of the present invention, as the amount of galangal rhizome, is preferably 0.01 to 100% by mass, more preferably 0.1 to 50% by mass, even more preferably 0.2 to 10% by mass, even more preferably 0.5 to 5% by mass, and particularly preferably 0.6 to 3% by mass.

[0013] The oral intake amount of the galangal extract of the present invention per dose is preferably 10 to 1000 mg, more preferably 50 to 500 mg, even more preferably 100 to 400 mg, and even more preferably 150 to 300 mg, in terms of the dry solid content of the galangal extract in the oral liquid composition of the present invention. Here, the "oral intake amount per dose" refers to the amount of the oral liquid composition of the present invention ingested at one time, more specifically, the amount ingested intermittently or continuously within a short period of time, for example, within about 30 minutes, and is, for example, 50 mL to 500 mL.

[0014] In the present invention, vitamin B2 refers to vitamin B2 or its derivatives or salts thereof, which are normally edible, and examples thereof include riboflavin, riboflavin phosphate, riboflavin butyrate, flavin adenine dinucleotide, and salts thereof. The salt used in the present invention is preferably a sodium salt, and in the present invention, riboflavin 5'-phosphate sodium is particularly preferred. The vitamin B2 used in the present invention can be produced by known methods, or commercially available products (such as riboflavin 5'-phosphate sodium manufactured by DSM and riboflavin 5'-phosphate sodium manufactured by Iwaki Pharmaceutical) can also be used.

[0015] The content of vitamin B2 in the oral liquid composition of the present invention is preferably 0.0001 to 0.1% by mass, more preferably 0.0005 to 0.02% by mass, and even more preferably 0.001 to 0.01% by mass.

[0016] In the oral liquid composition of the present invention, the mass ratio of the dry solid content of the galangal extract to the vitamin B2s, i.e., the content of the vitamin B2s per 1 mass part of the dry solid content of the galangal extract, is preferably 0.0002 to 100 mass parts, more preferably 0.0002 to 10 mass parts, even more preferably 0.03 to 10 mass parts, even more preferably 0.003 to 0.25 mass parts, and particularly preferably 0.006 to 0.25 mass parts.

[0017] In the oral liquid composition of the present invention, the mass ratio of the galangal rhizome-equivalent amount of galangal extract to vitamin B2s, i.e., the content of vitamin B2s per 1 mass part of the galangal rhizome-equivalent amount of galangal extract, is preferably 0.00002 to 10 mass parts, more preferably 0.00002 to 1 mass part, even more preferably 0.003 to 1 mass part, even more preferably 0.0003 to 0.025 mass parts, and particularly preferably 0.0006 to 0.025 mass parts.

[0018] In the present invention, caffeine is referred to as 1,3,7-trimethylxanthine, which is its chemical name. The present invention is not particularly limited to, but may use chemically synthesized products that can be produced by known methods, extracts of plants containing caffeine (coffee beans, tea leaves, kola berries, etc.) and concentrated purified products thereof, or commercially available products (e.g., caffeine extract manufactured by Shiratori Pharmaceutical)

[0019] From the viewpoint of sufficiently reducing the unpleasant odor derived from the galangal extract, the content of caffeine in the oral liquid composition of the present invention is preferably 0.001 to 1% by mass, more preferably 0.01 to 0.5% by mass, even more preferably 0.01 to 0.2% by mass, and even more preferably 0.02 to 0.2% by mass, and further more preferably 0.05 to 0.2% by mass.

[0020] In the oral liquid composition of the present invention, the mass ratio of the dry solid content of the galangal extract to the caffeine, i.e., the caffeine content per 1 mass part of the dry solid content of the galangal extract, is preferably 0.0001 to 200 mass parts, more preferably 0.0001 to 10 mass parts, and even more preferably 0.005 to 2.5 mass parts.

[0021] In the oral liquid composition of the present invention, the mass ratio of the galangal rhizome-equivalent amount of the galangal extract to the caffeine, i.e., the caffeine content per 1 mass part of the galangal rhizome-equivalent amount of the galangal extract, is preferably 0.00001 to 20 mass parts, more preferably 0.00001 to 1 mass part, and even more preferably 0.0005 to 0.25 mass parts.

[0022] In the oral liquid composition of the present invention, the mass ratio of vitamin B2 to caffeine, i.e., the content of caffeine per 1 mass part of vitamin B2, is preferably 0.001 to 100 mass parts, more preferably 0.001 to 50 mass parts, even more preferably 0.001 to 10 mass parts, even more preferably 0.001 to 5 mass parts, and particularly preferably 0.05 to 2.5 mass parts.

[0023] The chemical name for arginine or a salt thereof in the present invention is 2-amino-5-guanidinopentanoic acid or a salt thereof. L-arginine, D-arginine, or racemic DL-arginine may be used. In the present invention, free arginine or a salt form of arginine may be used. The salt form of arginine is not particularly limited as long as it is acceptable for consumption, and examples include hydrochloride, nitrate, sulfate, citrate, acetate, and glutamate. The arginine or arginine salt used in the present invention can be produced by known methods, or commercially available products (e.g., L-arginine manufactured by Nakahara Chemical Co., Ltd., arginine manufactured by Kyowa Hakko Bio Co., Ltd., and L-arginine manufactured by Ajinomoto Healthy Supply Co., Ltd.) can also be used.

[0024] From the viewpoint of sufficiently improving the unpleasant odor derived from the galangal extract, the content of arginine or a salt thereof in the oral liquid composition of the present invention is preferably 0.001 to 10% by mass, more preferably 0.01 to 5% by mass, and particularly preferably 0.05 to 1.5% by mass.

[0025] In the oral liquid composition of the present invention, the mass ratio of the dry solid content of the galangal extract to arginine or a salt thereof, i.e., the content of arginine or a salt thereof per 1 part by mass of the dry solid content of the galangal extract, is preferably 0.001 to 100 parts by mass, more preferably 0.01 to 50 parts by mass, and even more preferably 0.3 to 15 parts by mass.

[0026] In the oral liquid composition of the present invention, the mass ratio of the galangal extract equivalent to the galangal rhizome to arginine, i.e., the content of arginine per 1 mass part of the galangal extract equivalent to the galangal rhizome, is preferably 0.0001 to 10 mass parts, more preferably 0.001 to 5 mass parts, and even more preferably 0.03 to 1.5 mass parts.

[0027] In the oral liquid composition of the present invention, the mass ratio of vitamin B2 to arginine, i.e., the content of arginine per 1 mass part of vitamin B2, is preferably 0.1 to 200,000 mass parts, more preferably 10 to 15,000 mass parts, even more preferably 10 to 1,000 mass parts, and particularly preferably 10 to 300 mass parts.

[0028] The pH of the oral liquid composition of the present invention is not particularly limited, but from the viewpoint of drinkability, the lower limit is preferably 2.0 to 7.0, more preferably 2.5 to 4.5, and even more preferably 3.0 to 4.0. A commonly used pH adjuster can be used to adjust the pH of the oral liquid composition of the present invention. Specific pH adjusters include organic acids such as citric acid, malic acid, tartaric acid, succinic acid, lactic acid, acetic acid, maleic acid, gluconic acid, aspartic acid, adipic acid, glutamic acid, and fumaric acid, as well as salts thereof; inorganic acids such as hydrochloric acid; and inorganic bases such as sodium hydroxide. Preferred pH adjusters are citric acid and / or salts thereof, hydrochloric acid, and sodium hydroxide.

[0029] The oral liquid composition of the present invention may also contain other ingredients, such as vitamins other than vitamin B2, minerals, amino acids other than arginine or salts thereof, herbal medicines, herbal extracts, royal jelly, etc., as appropriate, within the scope of not impairing the effects of the present invention. Furthermore, the oral liquid composition of the present invention may also contain additives, such as antioxidants, colorants, flavorings, flavoring agents, surfactants, thickeners, stabilizers, preservatives, sweeteners, and acidulants, as appropriate, within the scope of not impairing the effects of the present invention.

[0030] The oral liquid composition of the present invention is not particularly limited as long as it is a liquid composition that can be taken orally, and examples thereof include pharmaceuticals, quasi-drugs, and foods (including functional foods, nutrient-functional foods, and foods for specified health uses). Pharmaceuticals and quasi-drugs include, for example, oral liquid preparations and energy drinks. Foods include, for example, soft drinks, carbonated drinks, sports and functional drinks, non-alcoholic drinks, milk drinks, tea drinks, coffee drinks, fruit and vegetable drinks, and jelly drinks.

[0031] The oral liquid composition of the present invention can be produced by a conventional method. For example, galangal extract and vitamin B2 are added to water, and then caffeine and / or arginine are added. If desired, the other ingredients described above are added and dissolved, and water is then added to adjust the volume. If necessary, the pH is adjusted or heat sterilized, and the resulting mixture is filled into a container to provide an easily portable oral liquid composition.

[0032] When the oral liquid composition of the present invention is used to prepare a carbonated beverage, for example, galangal extract and vitamin B2 are added to water, and then caffeine and / or arginine are added. If desired, other ingredients as described above are added and dissolved to prepare a concentrated beverage. After adjusting the pH and sterilizing by heating, if necessary, and cooling, the beverage is then pressurized with carbon dioxide (carbonation), filled into a container, and appropriately sterilized. The gas volume is preferably 0.5 to 4.0. The gas volume is the volume ratio of carbon dioxide dissolved in the solvent liquid to 1 part by volume under standard conditions (1 atmosphere, 20°C). Carbonated beverages can be produced by either the premix method or the postmix method, and either method may be used in the present invention. [Example]

[0033] The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited to these examples, etc. Commercially available products (riboflavin 5'-phosphate sodium: manufactured by DSM, caffeine extract: manufactured by Shiratori Pharmaceutical, L-arginine: manufactured by Kyowa Hakko Bio) were used in the following examples and comparative examples. (Extraction Examples 1-2, Comparative Examples 1-13, Examples 1-1-13)

[0034] Preparation of Galangal Extract: [Extraction Example 1: Hereinafter referred to as Galangal Extract A in the present invention] The galangal rhizome was extracted with hot water and concentrated under reduced pressure using a conventional method to obtain a dry powder (solid) extract in an amount one-tenth the mass of the galangal rhizome. [Extraction Example 2: Hereinafter referred to as Galangal Extract B in the present invention] Galangal rhizomes were extracted with hot water, and then enzyme treatment, filtration, and vacuum concentration were performed using standard methods to obtain a liquid extract with a Brix of 15 (soluble solid content of 15%). In the tables of the test examples, the amount of galangal extract A and B is shown as the amount converted to the dry solid content of galangal.

[0035] Preparation of Oral Liquid Composition: Oral liquid compositions were prepared according to the formulations shown in Tables 2 to 8 below and the following method. First, riboflavin 5'-phosphate sodium as vitamin B2, galangal extract A or galangal extract B, caffeine, or arginine were added to approximately 90% of the total volume of purified water, and the mixture was thoroughly stirred. After stirring, the pH was adjusted using hydrochloric acid and sodium hydroxide solution, and purified water was added to the total volume to obtain oral liquid compositions (Examples 1-1 to 13). Oral liquid compositions without galangal extract A or galangal extract B (Comparative Examples 1 to 13) served as controls.

[0036] The obtained oral liquid composition was filled in a screw tube No. 6 (manufactured by Maruemu Co., Ltd.) in an amount of 30 ml, and sterilized for 25 minutes at 80°C. The oral liquid composition prepared as described above was left to stand for 7 days under an illumination intensity of 3000 lux using the standard illuminant D65 defined by the International Commission on Illumination (CIE), and then smelled, and the degree of reduction in unpleasant odor was evaluated according to the criteria in Table 1.

[0037] [Table 1]

[0038] [Table 2]

[0039] [Table 3]

[0040] [Table 4]

[0041] [Table 5]

[0042] [Table 6]

[0043] [Table 7]

[0044] [Table 8]

[0045] As is clear from Tables 2 to 8, the compositions containing galangal extract and vitamin B2 and formulated with caffeine or arginine each showed an effect of reducing the unpleasant odor that occurs when galangal extract and vitamin B2 are contained, compared to the comparative examples.

[0046] (Examples 14 to 16) Liquid beverages and carbonated beverages were prepared according to the formulations shown in Table 9 and the following methods.

[0047] Preparation of liquid beverages: All ingredients except riboflavin 5'-phosphate sodium and sodium benzoate were dissolved in approximately 50% of the total volume of water. Separately, riboflavin 5'-phosphate sodium and sodium benzoate dissolved in approximately 10% of the total volume of 70°C water were added and thoroughly stirred. After stirring, the pH was adjusted with trisodium citrate, and purified water was added to the total volume to obtain oral liquid compositions (Examples 14 and 15). The resulting oral liquid compositions were filled into 100ml brown bottles, sealed, and sterilized at 80°C for 25 minutes. After sterilization, the prepared oral liquid compositions were left to stand for 7 days under standard light source D65 and 3000 lux illumination. The unpleasant odor characteristic of the inclusion of galangal extract and vitamin B2 was evaluated according to the evaluation criteria in Table 1, as in Examples 1-1 to 13 and Comparative Examples 1 to 13.

[0048] Preparation of carbonated beverages: All ingredients except riboflavin 5'-phosphate sodium and sodium benzoate were dissolved in approximately 10% of the total volume of water. Separately, riboflavin 5'-phosphate sodium and sodium benzoate dissolved in approximately 2.5% of the total volume of 70°C water were added and thoroughly stirred. After stirring, the pH was adjusted with trisodium citrate, and water was added to the mixture to make 25% of the total volume to prepare a beverage concentrate. This beverage concentrate was sterilized at 80°C for 25 minutes, made up to the total volume with carbonated water, and filled into a transparent, sealed container in 250 ml (Example 16). After filling, the prepared oral liquid composition was left to stand for 7 days under a standard light source D65 and an illumination intensity of 3,000 lux. The unpleasant odor characteristic of the inclusion of galangal extract and vitamin B2 was evaluated according to the evaluation criteria in Table 1, as in Examples 1-1 to 13 and Comparative Examples 1 to 13.

[0049] [Table 9]

[0050] As is clear from Table 9, it was confirmed that in Examples 14 to 16, when galangal extract and vitamin B2 were combined, the unpleasant odor was barely perceptible or only slightly perceptible. [Industrial Applicability]

[0051] The present invention makes it possible to suppress the unpleasant odor that occurs when galangal extract and vitamin B2 are combined in an oral liquid composition, and is therefore expected to provide oral liquid compositions with high marketability in the fields of pharmaceuticals, quasi-drugs, and foods.

Claims

1. An oral liquid composition comprising A) a galangal extract, B) a vitamin B2 type compound, and C) caffeine and / or arginine, wherein A) the concentration of the galangal extract is 0.001 to 1 mass% in terms of dry solid content, B) the concentration of the vitamin B2 type compound is 0.0005 to 0.02 mass%, and C) caffeine is 0.01 to 0.2 mass%.

2. 2. The oral liquid composition according to claim 1, which has a pH of 2.0 to 7.

0.

3. 3. The oral liquid composition according to claim 1, wherein the oral liquid composition is a liquid beverage.

4. An oral liquid composition characterized by containing A) galangal extract, B) vitamin B2, and C) caffeine and / or arginine, wherein A) the concentration of galangal extract is 0.001 to 1 mass% in terms of dry solid content, B) the concentration of vitamin B2 is 0.0005 to 0.02 mass%, and C) arginine is 0.01 to 1.5 mass%.

5. An oral liquid composition according to claim 4, having a pH of 2.0 to 7.

0.

6. An oral liquid composition according to claim 4 or 5, wherein the oral liquid composition is a liquid beverage.

7. A method for suppressing an unpleasant odor in a liquid composition containing 0.001 to 1% by mass of galangal extract and 0.0005 to 0.02% by mass of vitamin B2, calculated as a dry solid content, by adding 0.01 to 0.2% by mass of caffeine.

8. A method for suppressing an unpleasant odor in a liquid composition containing 0.001 to 1 mass % of galangal extract and 0.0005 to 0.02 mass % of vitamin B2, calculated as the dry solid content, by adding 0.01 to 1.5 mass % of arginine.

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