Compounds and compositions for treating conditions associated with NLRP activity

Abstract

To provide a NLRP3 activity regulator.SOLUTION: An activity regulator is characterized by a compound of formula AA or a pharmaceutically acceptable salt thereof. The compound of formula AA is NLRP3 activity regulator, and therefore, can be used for the treatment of metabolic disorder (e.g., TYPE 2 diabetes mellitus, atherosclerosis, obesity or gout), disease of central nervous system (e.g., Alzheimer disease, multiple sclerosis, amyotrophic lateral sclerosis or Parkinson disease), lung disease (e.g., asthma, COPD or idiopathic pulmonary fibrosis), liver disease (e.g., NASH syndrome, viral hepatitis or cirrhosis), pancreatic disease (e.g., acute pancreatitis or chronic pancreatitis), kidney disease (e.g., acute nephropathy or chronic nephropathy), intestinal disease (e.g., Crohn's disease or ulcerative colitis), dermatosis, musculoskeletal disease (e.g., scleroderma), vascular disease, bone disease, eye disease (e.g., glaucoma or macular degeneration), disease originated from virus infection, autoimmune disease, cancer or aging.SELECTED DRAWING: None

Description

[Technical Field]

[0001] Priority claim This application is a continuation of U.S. Provisional Patent Application No. 62 / 536,271, filed July 24, 2017. No. 62 / 573,894, filed October 18, 2017; and U.S. Provisional Patent Application No. 62 / 573,894, filed October 18, 2017. and claims the benefit of the provisional patent application filed on Dec. 1, 2002, ... both of which are incorporated herein by reference in their entirety. It is incorporated into the detailed text.

[0002] The present disclosure provides, for example, a decrease or increase in NLRP3 activity (e.g., an increase, e.g., an increase in NLRP3 activity). 3 signal transduction-related pathology, disease, or disorder) is a pathology in a subject (e.g., a human) a pathological condition, disease or disorder that contributes to the pathology and / or symptoms and / or progression of the disease or disorder Chemical substances useful for treating (e.g., modulating (e.g., antagonizing) NLRP3 ) compound, or a pharmaceutically acceptable salt and / or hydrate of this compound, and / or The present disclosure features compositions and methods for using the same. and other methods of making are also featured. [Background technology]

[0003] The NLRP3 inflammasome is a component of the inflammatory process, and its aberrant activation leads to clinical It causes hereditary disorders such as opioid-associated periodic syndrome (CAPS). Muckle-Wells syndrome (MWS), familial cold autoinflammatory syndrome (FCAS), and newborn Childhood-onset multisystem inflammatory disease (NOMID) is associated with gain-of-function mutations in NLRP3 These are examples of indications for which it has been reported to be effective.

[0004] NLRP3 can form a complex and is involved in a variety of diseases, including but not limited to, type 2 diabetes, atherosclerotic arteries, and the like. metabolic disorders such as sclerosis, obesity and gout, as well as Alzheimer's disease and multiple sclerosis and muscle Diseases of the central nervous system such as amyotrophic lateral sclerosis and Parkinson's disease, asthma and COPD and ataxia Lung diseases such as advanced pulmonary fibrosis, NASH syndrome, viral hepatitis and liver cirrhosis, Pancreatic diseases such as acute and chronic pancreatitis, kidney diseases such as acute and chronic renal failure, Crohn's disease and ulcers intestinal diseases such as idiopathic colitis, skin diseases such as psoriasis, musculoskeletal diseases such as scleroderma, giant cell arteritis vascular diseases such as osteoarthritis, bone disorders such as osteoporosis and osteopetrotic disorders, glaucoma and eye diseases such as macular degeneration, diseases caused by viral infections such as HIV and AIDS, Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and autoimmune thyroiditis, It is involved in the pathogenesis of many complex diseases, including Son's disease, pernicious anemia, cancer, and aging. Summary of the Invention [Problem to be solved by the invention]

[0005] In view of the above, it is desirable to provide compounds that modulate (e.g., antagonize) NLRP3. It would be desirable to do so. [Means for solving the problem]

[0006] The present disclosure relates to, for example, conditions, diseases, or disorders in which NLRP3 activity is decreased or increased (e.g., for treating a condition, disease, or disorder associated with NLRP3 signaling, e.g., an increase in Useful chemical compounds (e.g., compounds that modulate (e.g., antagonize) NLRP3, or a pharmaceutically acceptable salt, and / or hydrate, and / or co-crystal of this compound, and / or combination drugs).

[0007] In one embodiment, the compound of formula AA [ka] or a pharmaceutically acceptable salt thereof, wherein The variables may be as defined anywhere herein.

[0008] The disclosure also features compositions and other methods of using and making the same.

[0009] An "antagonist" of NLRP3 acts by directly binding to NLRP3 or by inhibiting the Inactivation, destabilization, altered distribution, or other means of LRP3 may result in the production of IL-1β and and / or compounds that inhibit the ability of NLRP3 to induce the production of IL-18.

[0010] In one embodiment, a chemical entity described herein (e.g., a chemical entity generally described herein) means a specifically described compound or a pharmaceutically acceptable salt thereof, or a composition containing the same) and one or more pharmaceutically acceptable excipients.

[0011] In one embodiment, modulating (e.g., stimulating, partially stimulating) NLRP3 activity. a method for inhibiting or antagonizing NLRP3, the method comprising: Substances (e.g., compounds generally or specifically described herein or their pharmaceutically acceptable salts) The method is characterized by the step of contacting the compound with an acceptable salt thereof or a composition containing the same. The method may be an in vitro method, e.g., a method comprising contacting a sample containing one or more cells containing NLRP3. This includes in vivo methods as well as in vivo methods.

[0012] In a further embodiment, NLRP3 signaling is associated with disease pathology and / or symptoms and / or A method of treating a disease in which the progression of a disease is contributed to by administering an effective

[0033] Effective amounts of chemical entities described herein (e.g., those described generally or specifically herein) a step of administering a compound described above or a pharmaceutically acceptable salt thereof, or a composition containing the compound described above The method is characterized by the steps of:

[0013] In further embodiments, the chemical entities described herein (e.g., those generally described herein) are or a specifically described compound or a pharmaceutically acceptable salt thereof or a composition containing the same administering to a subject a compound (composition) containing the compound to treat a disease in which NLRP3 signaling is mediated by the compound; administered in an amount effective to treat the disease contributing to the alterations and / or symptoms and / or progression, The present invention features a method of treatment, including the step of treating a disease.

[0014] Implementations may include one or more of the following features.

[0015] The chemical entity may be one or more additional agents suitable for treating a condition, disease, or disorder. It may be administered in combination with other treatments.

[0016] Examples of indications that may be treated by the compounds disclosed herein include, but are not limited to: However, metabolic disorders such as type 2 diabetes, atherosclerosis, obesity and gout, as well as arterial Central nervous system diseases such as Zheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Parkinson's disease Diseases of the nervous system, asthma and lung diseases such as COPD and idiopathic pulmonary fibrosis, NASH syndrome, viruses liver diseases such as hepatitis and cirrhosis, pancreatic diseases such as acute and chronic pancreatitis, acute and chronic kidney disease kidney diseases such as ulcerative colitis and Crohn's disease; intestinal diseases such as psoriasis; Musculoskeletal diseases such as rheumatoid arthritis, vascular diseases such as giant cell arteritis, osteoarthritis, osteoporosis and osteoporosis Bone disorders such as osteopetrosis, eye diseases such as glaucoma and macular degeneration, HIV and AIDS Diseases caused by viral infections such as rheumatoid arthritis, systemic lupus erythematosus, and autoimmune diseases autoimmune diseases such as chronic thyroiditis; Addison's disease, pernicious anemia, cancer, and aging.

[0017] The method may further comprise identifying the subject.

[0018] Other embodiments include those described in the detailed description and / or claims.

[0019] Further definitions To facilitate understanding of the disclosure set forth herein, some additional terms are provided below. Generally, the nomenclature used herein, as well as the The laboratory procedures in organic chemistry, medicinal chemistry, and pharmacology used in Unless otherwise defined, the terms used in this specification are All technical and scientific terms used are commonly understood by one of ordinary skill in the art to which this disclosure belongs. The patents referenced throughout this specification have the same meaning as commonly understood by those skilled in the art. Each of the applications, published applications, and other publications and accompanying appendices is incorporated by reference in its entirety. The present application is incorporated by reference.

[0020] As used herein, the term "NLRP3" includes, but is not limited to, Acids, polynucleotides, oligonucleotides, sense and antisense polynucleotides Chains, complementary sequences, peptides, polypeptides, proteins, homologous and / or orthologous NLRs P3 molecules, isoforms, precursors, mutants, variants, derivatives, splice variants, pairs It is intended to include all islets, different species, as well as active fragments thereof.

[0021] As used herein, the term "acceptable" in reference to a formulation, composition, or ingredient The term "anticoagulant" means that the drug has no lasting adverse effects on the overall health of the subject being treated. Taste.

[0022] "API" refers to active pharmaceutical ingredients.

[0023] The term "effective amount" or "therapeutically effective amount" as used herein means a therapeutically effective amount. An administered chemical (e.g., A compound exhibiting activity as a modulator of NLRP3, or a pharmaceutically acceptable salt and / or The result is a sufficient amount of the compound (or hydrate and / or co-crystal) to eliminate signs, symptoms, or even eliminate disease. or reduction and / or alleviation of the causes, or any other desired alteration of a biological system. For example, an "effective amount" for therapeutic use is that amount needed to provide a clinically significant reduction in disease symptoms. The amount of a composition containing a compound disclosed herein that is suitable for any individual case. Such an "effective" amount may be determined using any suitable technique, such as a dose escalation study.

[0024] The term "excipient" or "pharmaceutically acceptable excipient" refers to a liquid or solid filler , diluents, carriers, solvents, or encapsulating materials, In one embodiment, each component is compatible with the other components of the pharmaceutical formulation. , without excessive toxicity, irritation, allergic reaction, immunogenicity, or other problems or complications. Suitable for use in contact with tissues or organs of dogs and animals, and has reasonable benefit / "Pharmaceutically acceptable" in the sense that it is commensurate with the risk ratio. ton:The Science and Practice of Pharmacy ,21st ed.;Lippincott Williams & Wilkins: Philadelphia,PA,2005;Handbook of Pharmac eutical excipients,6th ed.;Rowe et al.,E ds.;The Pharmaceutical Press and the Ame rican Pharmaceutical Association:2009;Ha ndbook of Pharmaceutical Additives,3rd e d.;Ash and Ash Eds.;Gower Publishing Com pany:2007;Pharmaceutical Preformulation and Formulation,2nd ed.;Gibson Ed.;CRC P See Ress LLC: Boca Raton, FL, 2009.

[0025] The term "pharmaceutically acceptable salts" refers to pharmaceutically acceptable salts of compounds of inorganic and organic acids. It may refer to pharmaceutically acceptable addition salts prepared from non-toxic acids. Acceptable salts can be prepared by reacting the compounds described herein with an acid such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, or the like. Acids such as methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, and salicylic acid The term "pharmaceutically acceptable salt" refers to a pharmaceutically acceptable salt of an acid group. The compound having the formula (I) is dissolved in an alkali metal salt such as an ammonium salt, a sodium salt, or a potassium salt. alkaline earth metal salts such as metal salts, calcium salts or magnesium salts, dicyclohexyl Glucamine, N-methyl-D-glucamine, tris(hydroxymethyl)methylamine, etc. to form salts with organic bases, and salts with amino acids such as arginine and lysine. or by other methods already established. A pharmacologically acceptable salt may also refer to a pharmacologically acceptable addition salt. Examples of salts that the compounds described herein may form with bases include: These include: sodium, potassium, magnesium, calcium, and aluminum. and its salts with inorganic bases; organic salts such as methylamine, ethylamine and ethanolamine its salts with basic amino acids such as lysine and ornithine; and ammonia Salts include the following: hydrochloric, hydrobromic, hydroiodic, sulfuric, nitric, and Mineral acids such as phosphoric acid, formic acid, acetic acid, propionic acid, oxalic acid, malonic acid, succinic acid, fumaric acid Acid, maleic acid, lactic acid, malic acid, tartaric acid, citric acid, methanesulfonic acid, and ethanesulfonic acid acid addition with organic acids such as sulfonic acid; acidic amino acids such as aspartic acid and glutamic acid The salts may be acid addition salts, as specifically exemplified by salts.

[0026] The term "pharmaceutical composition" refers to a pharmaceutical composition containing a compound described herein and a carrier, stabilizer, diluent, or the like. , dispersants, suspending agents, and / or thickening agents (collectively referred to herein) A pharmaceutical composition refers to a mixture of a compound with other substances (called "excipients") that facilitates administration of the compound to an organism. These include, but are not limited to: rectal, oral, intravenous, aerosol, parenteral, ocular, pulmonary, and Multiple techniques exist in the art for administering compounds, including topical administration.

[0027] The term "subject" includes, but is not limited to, primates (e.g., humans), monkeys, bovines, "Animal" refers to an animal, including a cat, sheep, goat, horse, dog, cat, rabbit, rat, or mouse. The terms "subject" and "patient" are used herein in reference to a mammalian subject, e.g., a human. are used synonymously in the book.

[0028] "Treat" in the context of treating a disease or disorder The terms "treating" and "treatment" refer to a disorder, disease, or condition, or alleviating or arresting one or more symptoms of a disorder, disease, or condition or slow the progression, spread, or worsening of a disease, disorder, or condition or one or more symptoms thereof. It is intended to include making

[0029] The terms "hydrogen" and "H" are used interchangeably herein.

[0030] The term "halo" refers to fluoro (F), chloro (Cl), bromo (Br), or iodine. Refers to the letter I.

[0031] The term "alkyl" refers to any straight or branched chain, saturated alkyl group containing the indicated number of carbon atoms. or unsaturated hydrocarbon chains. For example, C 1~10 has 1 to 10 groups indicates that the following carbon atoms may be present therein: non-limiting examples include methyl, ethyl , isopropyl, tert-butyl, and n-hexyl.

[0032] The term "haloalkyl" refers to an alkyl group in which one or more hydrogen atoms are replaced with independently selected halo. It refers to an alkyl group.

[0033] The term "alkoxy" refers to an -O-alkyl group (e.g., -OCH3).

[0034] The term "carbocycle" as used herein refers to a ring of 3 to 10 carbons, e.g. an optionally substituted aromatic or Examples of carbocycles include 5-, 6-, and 7-membered carbocycles. It can be obtained.

[0035] The term "heterocycle" refers to a ring system containing 1 to 3 heteroatoms in a monocyclic system and 1 to 3 heteroatoms in a bicyclic system. Aromatic or non-aromatic, with 6 heteroatoms, or 1-9 heteroatoms if tricyclic refers to aromatic 5- to 8-membered monocyclic, 8- to 12-membered bicyclic, or 11- to 14-membered tricyclic ring systems, The heteroatoms are selected from O, N, or S (e.g., carbon atoms and monocyclic, bicyclic, or In the case of tricyclic rings, 1 to 3, 1 to 6, or 1 to 9 heteroatoms of N, O, or S, respectively 0, 1, 2, or 3 atoms in each ring may be substituted by a substituent. Examples of heterocyclic rings include: Examples include 5-, 6-, and 7-membered heterocycles.

[0036] The term "cycloalkyl" as used herein refers to a group of 3 to 10 carbon atoms. non-aromatic cyclic, bicyclic, fused rings, e.g., having 3 to 8 carbons, e.g., 3 to 7 carbons; Cycloalkyl groups may be optionally substituted, including cycloalkyl groups, spiro hydrocarbon groups, and the cycloalkyl groups may be optionally substituted. Examples of chloroalkyl include 5-, 6-, and 7-membered rings. Propyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclo Examples include hexenyl, cycloheptyl, and cyclooctyl.

[0037] The term "heterocycloalkyl" refers to a ring system having 1 to 3 heteroatoms in the case of a monocyclic ring, 1 to 3 heteroatoms in the case of a bicyclic ring, having 1 to 6 heteroatoms in the case of the formula, or 1 to 9 heteroatoms in the case of the tricyclic formula, non-aromatic 5- to 8-membered monocyclic, 8- to 12-membered bicyclic, or 11- to 14-membered tricyclic ring, fused, or refers to a spiro group, wherein the heteroatom is selected from O, N, or S (e.g., a carbon atom, and 1 to 3, 1 to 6, or 1 to 9 in the case of monocyclic, bicyclic, or tricyclic rings, respectively. N, O, or S heteroatoms), 0, 1, 2, or 3 atoms of each ring may be substituted with a substituent Examples of heterocycloalkyl include 5-, 6-, and 7-membered heterocycles. Examples include piperazinyl, pyrrolidinyl, dioxanyl, morpholinyl, tetrahydrofuran, and the like. Examples include Drofranil.

[0038] The term "aryl" may refer to an aromatic ring group containing 6 to 10 ring carbons. Examples include phenyl and naphthyl.

[0039] The term "heteroaryl" refers to a heterocyclic ring which may be a single ring, two fused rings, or three fused rings. It is intended to mean an aromatic ring system containing 5 to 14 aromatic ring atoms, where at least At least one aromatic ring atom is selected from the group consisting of, but not limited to, O, S, and N. Examples include furanyl, thienyl, pyrrolyl, imidazolyl, and oxazolyl. aryl, thiazolyl, isoxazolyl, pyrazolyl, isothiazolyl, oxadiazolyl , triazolyl, thiadiazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl Examples include carbazolyl, quinolizinyl, quinolinyl, and triazinyl. nyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, Triazinyl, indolyl, isoindolyl, indazolyl, indolizinyl, purinyl , naphthyridinyl, pteridinyl, carbazolyl, acridinyl, phenazinyl, pheno Thiazinil, phenoxazinil, benzoxazolyl, benzothiazolyl, 1H-benz Imidazolyl, imidazopyridinyl, benzothienyl, benzofuranyl, isobenzofuranyl Examples include:

[0040] The term "hydroxy" refers to an OH group.

[0041] The term "amino" refers to the group NH2.

[0042] The term "oxo" refers to O. For example, replacement of a CH group with oxo results in A C=O group is obtained.

[0043] As used herein, the term "ring A" or "A" means [ka] are used interchangeably to denote [ka] The bond shown to be broken by the formula AA is shown to be broken by the formula S(O)(NHR 3 )= Linked to N moiety.

[0044] As used herein, the term "Ring B" or "B" means [ka] are used interchangeably to denote [ka] The bond shown broken by connects B to the NH(CO) group in formula AA. do.

[0045] As used herein, the term "optionally substituted ring A" refers to [ka] In formula AA, the wavy line [ka] The bond shown to be broken by the formula AA is shown to be broken by the formula S(O)(NHR 3 )= Linked to N moiety.

[0046] As used herein, the term "substituted ring B" means [ka] In formula AA, the wavy line [ka] The bond shown broken by connects B to the NH(CO) group in formula AA. do.

[0047] As used herein, the designation "S(O2)" refers to a single or larger As part of the notation, [ka] Refers to...

[0048] Furthermore, the atoms constituting the compounds of the present invention include all isotopic forms of such atoms. As used herein, isotopes are groups having the same atomic number. includes atoms having different mass numbers. By way of general example and not limitation, isotopes of hydrogen Examples of isotopes of carbon include tritium and deuterium, and examples of isotopes of carbon include: 13 C and 14 C Examples include:

[0049] The scope of the compounds disclosed herein includes tautomeric forms of the compounds. For example, part [ka] Compounds represented as containing the moiety [ka] Further examples include tautomeric forms containing the moiety [ka] Compounds represented as containing the moiety [ka] It is intended to include tautomeric forms containing:

[0050] Non-limiting exemplary compounds of the formulae described herein may contain stereocenters. enic) sulfur atom and optionally one or more stereogenic carbon atoms. Examples of isomeric mixtures (e.g., racemic mixtures of enantiomers; mixtures of diastereomers) The present disclosure provides methods for separating the individual components of said stereoisomeric mixture (e.g., racemic A method for resolving the enantiomers of a mixture is also described and exemplified. For compounds containing , the resolved enantiomers can be depicted using one of the two following formats: Shown are: Equation A / B (3D representation of dashed and solid wedge shapes); and Equation C ( * is displayed (flat structure with a stereogenic sulfur center). [ka]

[0051] In the reaction scheme showing the resolution of a racemic mixture, formulas A / B and C represent the constituent enantiomers The only purpose is to show that the product was resolved in enantiopure form (approximately 98% ee or greater). The scheme showing the resolution products using the formula A / B format is shown in Fig. 1. The absolute configuration and elution order are It is not intended to disclose or suggest any correlation between the compounds shown in the table below. Some are depicted using the formula A / B format. However, compounds 181a and 181b are For each of the listed compounds depicted in Formula A / B format, except for 1b, The stereochemistry shown is a tentative assignment and, by analogy, is that of compound 181. b (see, for example, Figures 1 and 2).

[0052] The details of one or more embodiments of the invention are set forth in the accompanying drawings and the description below. Other features and advantages of the invention will become apparent from the description and drawings, and from the claims. It would be. [Brief explanation of the drawings]

[0053] [Figure 1] A ball-and-stick representation of two crystallographically independent molecules of compound 181a in the asymmetric unit is shown. [Figure 2] A ball-and-stick representation of two crystallographically independent molecules of compound 181b in the asymmetric unit is shown. [Figure 3] 1 shows the microplate layout used in the hTHP-1 assay. DETAILED DESCRIPTION OF THE INVENTION

[0054] In one embodiment, the compound of formula AA [ka] (In the formula, m=0, 1, or 2; n=0, 1, or 2; o=1 or 2; p=0, 1, 2, or 3; where: A is a 5- to 10-membered heteroaryl or C6-C 10 is aryl; B is a 5- to 10-membered heteroaryl or C6-C 10 is aryl; where: At least one R 6 The B ring of formula AA is NR 3 (CO) group to the bond ult; R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl, CO-(5- to 10-membered heteroaryl), C O2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl , OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered ~7-membered heterocycloalkyl), C6-C 10 aryl, 5- to 10-membered heteroaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, NHCOC1-C6 alkyl Lukil, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl), N HCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl, NHCO OC1-C6 alkyl, NH-(C=NR 13 )NR 11 R 12 ,CONR 8 R 9 ,SCIENCE FICTION 5. SC1-C6 alkyl, S(O2)C1-C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl, C3-C7 cycloalkyl, and 3- to 7-membered heterocycloalkyl selected from alkyl, where C1-C6 alkyl, C1-C6 haloalkyl, C3-C7 cycloalkyl, and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1 to C6 Alkyl, C1-C6 alkoxy, COOC1-C6 alkyl, NR 8 R 9 ,CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl Reel, OCOC1~C6 alkyl, OCOC6~C 10 Aryl, OCO(5-10 1-membered heteroaryl), and OCO (3- to 7-membered heterocycloalkyl), NHCOC C6 alkyl, NHCOC6~C 10 Aryl, NHCO(5- to 10-membered heteroaryl ), NHCO(3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkynyl optionally substituted with one or more substituents each independently selected from: where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R 2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituent is further optionally substituted independently with 1 to 3 hydroxy, halo, or oxo. Re; where R 1 or R 2 C1-C6 alkyl, R 1 or R 2 C1~C6 Halo Alkyl, R 1 or R 2 C3-C7 cycloalkyl, or R 1 or R 2 3 members 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl or 5- to 10-membered heteroaryl includes halo, C1-C6 alkyl, oxo, and OC1 Optionally substituted with one or more substituents independently selected from C-C alkyl; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from optionally independently substituted, wherein C1-C6 alkyl and C1-C6 alkoxy are Hydroxy, halo, oxo, COOC1-C6 alkyl, C6-C 10 Aryl, and C ONR 8 R 9 optionally replaced by; R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, SC1~C6 alkyl, S(O2)C1~C6 alkyl, C3~C1 0 cycloalkyl, 3- to 10-membered heterocycloalkyl, and C2-C6 alkenyl Selected, where R 6 and R 7 are hydroxy, halo, CN, oxo, and C1-C6 alkoxy groups, respectively. Kyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C ONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 membered Heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO(5 3- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCOC 1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl cycloalkyl), NHCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl , C6~C 10 aryloxy, and S(O2)C1-C6 alkyl; wherein R 6 or R 7 is replaced by C1 -C6 alkyl or C1-C6 alkoxy is one or more of hydroxyl, halo, C6-C 10 Aryl or NR 8 R 9 or R 6 or R 7 5 to 7 members Carbocyclic or containing one or two heteroatoms independently selected from oxygen, sulfur, and nitrogen optionally fused to a heterocycle; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of Together, at least one C4-C8 carbocyclic ring or O, N, NR 20 , and S At least one 4- to 8-membered heterocyclic ring containing one or two heteroatoms selected from the group consisting of independently form a ring, wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 optionally independently substituted with one or more substituents independently selected from: R 4 and R 5 each is independently selected from hydrogen and C1-C6 alkyl; R 10 is C1-C6 alkyl; R 8 and R 9 each occurrence is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C=NR 13 )NR 11 R 12 , S( O2)C1-C6 alkyl, S(O2)NR 11 R 12 , C.O.R. 13 , CO2R 13 and CONR 11 R 12 wherein C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl is one or more of hydroxy, halo, oxo, C1-C6 alkynyl. Koxy, C2-C6 alkynyl, CO2R 13 , C6~C 10 Aryl, 5-10 membered aryl Any of heteroaryl, C3-C7 cycloalkyl, or 3- to 7-membered heterocycloalkyl optionally substituted; or R 8 and R 9 together with the nitrogen to which they are attached, a 3- to 7-membered ring optionally containing one or more heteroatoms in addition to the nitrogen to which they are attached Forming; R 13 is C1-C6 alkyl, C6-C 10 Aryl or 5- to 10-membered heteroaryl It is a rule; R 11 and R 12 Each occurrence of is independently selected from hydrogen and C1-C6 alkyl. Selected from kill; Each R 3 are independently hydrogen, cyano, hydroxy, C1-C6 alkoxy, C1-C6 Alkyl, CO2C1-C6 alkyl, and [ka] wherein the C1-C2 alkylene group is optionally substituted with oxo; R 14 is hydrogen, C1-C6 alkyl, 5- to 10-membered monocyclic or bicyclic heteroaryl C6-C 10 monocyclic or bicyclic aryl, wherein each C1-C6 alkyl Aryl, aryl, or heteroaryl may be one, two, or three R 6 Optionally placed independently (to be exchanged) Compounds of; or a pharmaceutically acceptable salt thereof is provided herein.

[0055] In one embodiment, the compound of formula AA [ka] (In the formula, m=0, 1, or 2; n=0, 1, or 2; o=1 or 2; p=0, 1, 2, or 3; where: A is a 5- to 10-membered heteroaryl or C6-C 10 is aryl; B is a 5- to 10-membered heteroaryl or C6-C 10 is aryl; where: At least one R 6 The B ring of formula AA is NR 3 (CO) group to the bond ult; R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl, CO-(5- to 10-membered heteroaryl), C O2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl , OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered ~7-membered heterocycloalkyl), C6-C 10 aryl, 5- to 10-membered heteroaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, NHCOC1-C6 alkyl Lukil, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl), N HCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl, NHCO OC1-C6 alkyl, NH-(C=NR 13 )NR 11 R 12 ,CONR 8 R 9 ,SCIENCE FICTION 5. SC1-C6 alkyl, S(O2)C1-C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl, C3-C7 cycloalkyl, and 3- to 7-membered heterocycloalkyl selected from alkyl, where C1-C6 alkyl, C1-C6 haloalkyl, C3-C7 cycloalkyl, and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1 to C6 Alkyl, C1-C6 alkoxy, COOC1-C6 alkyl, NR 8 R 9 ,CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl Reel, OCOC1~C6 alkyl, OCOC6~C 10 Aryl, OCO(5-10 1-membered heteroaryl), and OCO (3- to 7-membered heterocycloalkyl), NHCOC C6 alkyl, NHCOC6~C 10 Aryl, NHCO(5- to 10-membered heteroaryl ), NHCO(3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkynyl optionally substituted with one or more substituents each independently selected from: where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R 2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituent is further optionally substituted independently with 1 to 3 hydroxy, halo, or oxo. Re; where R 1 or R 2 C1-C6 alkyl, R 1 or R 2 C1~C6 Halo Alkyl, R 1 or R 2 C3-C7 cycloalkyl, or R 1 or R 2 3 members 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl or 5- to 10-membered heteroaryl includes halo, C1-C6 alkyl, oxo, and OC1 Optionally substituted with one or more substituents independently selected from C-C alkyl; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from optionally independently substituted, wherein C1-C6 alkyl and C1-C6 alkoxy are Hydroxy, halo, oxo, COOC1-C6 alkyl, C6-C 10 Aryl, and C ONR 8 R 9 optionally replaced by; R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, SC1~C6 alkyl, S(O2)C1~C6 alkyl, C3~C1 0 cycloalkyl, 3- to 10-membered heterocycloalkyl, and C2-C6 alkenyl Selected, where R 6 and R 7 are hydroxy, halo, CN, oxo, and C1-C6 alkoxy groups, respectively. Kyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C ONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 membered Heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO(5 3- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCOC 1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl cycloalkyl), NHCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl , C6~C 10 aryloxy, and S(O2)C1-C6 alkyl; wherein R 6 or R 7 is replaced by C1 -C6 alkyl or C1-C6 alkoxy is one or more of hydroxyl, halo, C6-C 10 Aryl or NR 8 R 9 or R 6 or R 7 5 to 7 members Carbocyclic or containing one or two heteroatoms independently selected from oxygen, sulfur, and nitrogen optionally fused to a heterocycle; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from optionally substituted with one or more substituents independently selected from R 10 is C1-C6 alkyl; R 8 and R 9 each occurrence is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C=NR 13 )NR 11 R 12 , S( O2)C1-C6 alkyl, S(O2)NR 11 R 12 , C.O.R. 13 , CO2R 13 and CONR 11 R 12 wherein C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl is one or more of hydroxy, halo, oxo, C1-C6 alkynyl. Koxy, C2-C6 alkynyl, CO2R 13 , C6~C 10 Aryl, 5-10 membered aryl Any of heteroaryl, C3-C7 cycloalkyl, or 3- to 7-membered heterocycloalkyl optionally substituted; or R 8 and R 9 together with the nitrogen to which they are attached, a 3- to 7-membered ring optionally containing one or more heteroatoms in addition to the nitrogen to which they are attached Forming; R 13 is C1-C6 alkyl, C6-C 10 Aryl or 5- to 10-membered heteroaryl It is a rule; R 11 and R12 Each occurrence of is independently selected from hydrogen and C1-C6 alkyl. Selected from kill; Each R 3 are independently hydrogen, cyano, hydroxy, C1-C6 alkoxy, C1-C6 Alkyl, CO2C1-C6 alkyl, and [ka] wherein the C1-C2 alkylene group is optionally substituted with oxo; R 14 is hydrogen, C1-C6 alkyl, 5- to 10-membered monocyclic or bicyclic heteroaryl C6-C 10 monocyclic or bicyclic aryl, wherein each C1-C6 alkyl Aryl, aryl, or heteroaryl may be one, two, or three R 6 Optionally placed independently (to be exchanged) Compounds of; or a pharmaceutically acceptable salt thereof is provided herein.

[0056] In one embodiment, the compound of formula AA [ka] (In the formula, m=0, 1, or 2; n=0, 1, or 2; o=1 or 2; p=0, 1, 2, or 3; where: A is a 5- to 10-membered heteroaryl or C6-C 10 is aryl; B is a 5- to 10-membered heteroaryl or C6-C 10 is aryl; where: At least one R 6 The B ring of formula AA is NR 3(CO) group to the bond ult; R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl, CO-(5- to 10-membered heteroaryl), C O2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl , OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered ~7-membered heterocycloalkyl), C6-C 10 aryl, 5- to 10-membered heteroaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, NHCOC1-C6 alkyl Lukil, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl), N HCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl, NHCO OC1-C6 alkyl, NH-(C=NR 13 )NR 11 R 12 ,CONR 8 R 9 ,SCIENCE FICTION 5. SC1-C6 alkyl, S(O2)C1-C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl, C3-C7 cycloalkyl, and 3- to 7-membered heterocycloalkyl selected from alkyl, where C1-C6 alkyl, C1-C6 haloalkyl, C3-C7 cycloalkyl, and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1 to C6 Alkyl, C1-C6 alkoxy, NR 8 R9 , =NR 10 , COOC1~C6 alkyl ,CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-1 0-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO (5- to 10-membered heteroaryl), and OCO(3- to 7-membered heterocycloalkyl), N HCOC1~C6 alkyl, NHCOC6~C 10 Aryl, NHCO (5-10 membered NHCO(3- to 7-membered heterocycloalkyl), and NHCOC 6 optionally substituted with one or more substituents each independently selected from alkynyl; ;; where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R 2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituents are 1 to 3 hydroxy, halo, NR 8 R 9 or oxo and optionally independently and replaced; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 1 and R 2At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from optionally independently substituted, wherein C1-C6 alkyl and C1-C6 alkoxy are Hydroxy, Halo, Oxo, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 optionally replaced by; R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9, SF5, SC1~C6 alkyl, S(O2)C1~C6 alkyl, C3~C1 0 cycloalkyl, 3- to 10-membered heterocycloalkyl, and C2-C6 alkenyl Selected, where R 6 and R 7 are hydroxy, halo, CN, oxo, and C1-C6 alkoxy groups, respectively. Kyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C ONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 membered Heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO(5 3- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCOC 1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl cycloalkyl), NHCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl , C6~C 10 aryloxy, and S(O2)C1-C6 alkyl; wherein R 6 or R 7 is replaced by C1 -C6 alkyl or C1-C6 alkoxy is one or more of hydroxyl, halo, C6-C 10 Aryl or NR 8 R 9 or R 6 or R 7 is oxygen, sulfur and nitrogen, and optionally halo; optionally fused to an optionally substituted 5- to 7-membered carbocyclic or heterocyclic ring; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from optionally substituted with one or more substituents independently selected from R 10 is C1-C6 alkyl; R 8 and R 9 each occurrence is independently hydrogen, C1-C6 alkyl, (C=NR 13 )NR 11 R 12 , S(O2)C1-C6 alkyl, S(O2)NR 11 R 12 , C.O.R. 13 , CO2R 13and CONR 11 R 12 where C1 is selected from -C6 alkyl is one or more of hydroxy, halo, C1-C6 alkoxy, C6-C 10 Aryl, 5- to 10-membered heteroaryl, C3-C7 cycloalkyl or 3- to 7-membered heteroaryl or R 8 and R 9 are the nitrogen atoms to which they are bonded. together with the nitrogen, optionally containing one or more heteroatoms in addition to the nitrogen to which they are attached. Form a 3- to 7-membered ring containing: R 13 is C1-C6 alkyl, C6-C 10 Aryl or 5- to 10-membered heteroaryl It is a rule; R 11 and R 12 Each occurrence of is independently selected from hydrogen and C1-C6 alkyl. Selected from kill; R 3 is hydrogen, cyano, hydroxy, C1-C6 alkoxy, C1-C6 alkyl, C O2C1-C6 alkyl, and [ka] wherein the C1-C2 alkylene group is optionally substituted with oxo; R 14 is hydrogen, C1-C6 alkyl, 5- to 10-membered monocyclic or bicyclic heteroaryl C6-C 10 monocyclic or bicyclic aryl, wherein each C1-C6 alkyl Aryl, aryl, or heteroaryl may be one, two, or three R 6 Optionally placed independently (to be exchanged) Compounds of; or a pharmaceutically acceptable salt thereof is provided herein.

[0057] In one embodiment, the compound of formula AA [ka] (In the formula, m=0, 1, or 2; n=0, 1, or 2; o=1 or 2; p=0, 1, 2, or 3; where: A is a 5- to 10-membered monocyclic or bicyclic heteroaryl or a C6-C 10 Monocyclic or is a bicyclic aryl; B is a 5- to 10-membered monocyclic or bicyclic heteroaryl or a C6-C 10 Monocyclic or is a bicyclic aryl; where: At least one R 6 The B ring of formula AA is NR 3 (CO) group to the bond ult; R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl, CO (5- to 10-membered heteroaryl), CO 2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, N H2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, NHCOC1-C6 alk Kill, NHCOC6~C10 Aryl, NHCO (5- to 10-membered heteroaryl), NH CO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl, NHCOO CC1-C6 alkyl, NH-(C=NR 13 )NR 11 R 12 ,CONR 8 R 9 ,SCIENCE FICTION 5. SC1-C6 alkyl, S(O2)C1-C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl, C3-C7 cycloalkyl and 3- to 7-membered heterocyclo alkyl, Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituents are 1 to 3 hydroxy, halo, NR 8 R 9 or oxo and optionally independently and replaced; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from optionally independently substituted, wherein C1-C6 alkyl and C1-C6 alkoxy are Hydroxy, Halo, Oxo, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10Aryl, and CONR 8 R 9 optionally replaced by; R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, SC1~C6 alkyl, S(O2)C1~C6 alkyl, C3~C1 0 cycloalkyl and 3- to 10-membered heterocycloalkyl, and C2 to C6 alkenyl are selected from where R 6 and R 7 are hydroxy, halo, CN, oxo, and C1-C6 alkoxy groups, respectively. Kyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C ONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 membered Heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO(5 3- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCOC 1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl cycloalkyl), NHCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl , C6~C 10 aryloxy, and S(O2)C1-C6 alkyl; wherein R 6 or R 7 is replaced by C1 -C6 alkyl or C1-C6 alkoxy is one or more hydroxyl, C6-C 10 a Reel or NR 8 R 9 or R 6 or R 7 is a 5- to 7-membered carbocyclic ring or a complex containing one or two heteroatoms independently selected from oxygen, sulfur and nitrogen optionally fused to a ring; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from optionally substituted with one or more substituents independently selected from R 10 is C1-C6 alkyl; R 8 and R 9 each occurrence is independently hydrogen, C1-C6 alkyl, (C=NR 13 )NR 11 R 12 , S(O2)C1-C6 alkyl, S(O2)NR 11 R 12 , C.O.R. 13 , CO2R 13 and CONR 11 R 12 where C1 is selected from -C6 alkyl is one or more of hydroxy, halo, C1-C6 alkoxy, C6-C 10 Aryl, 5- to 10-membered heteroaryl, C3-C7 cycloalkyl or 3- to 7-membered heteroaryl or R 8 and R 9 are the nitrogen atoms to which they are bonded. together with the nitrogen, optionally containing one or more heteroatoms in addition to the nitrogen to which they are attached. Form a 3- to 7-membered ring containing: R 13 is C1-C6 alkyl, C6-C 10 Aryl or 5- to 10-membered heteroaryl It is a rule; R 11 and R 12 Each occurrence of is independently selected from hydrogen and C1-C6 alkyl. Selected from kill; R 3is hydrogen, cyano, hydroxy, C1-C6 alkoxy, C1-C6 alkyl, and Beauty [ka] wherein the C1-C2 alkylene group is optionally substituted with oxo; R 14 is hydrogen, C1-C6 alkyl, 5- to 10-membered monocyclic or bicyclic heteroaryl C6-C 10 monocyclic or bicyclic aryl, wherein each C1-C6 aryl alkyl, aryl, or heteroaryl is one or two R 6 Optionally and independently replaced by will be) Compounds of; or a pharmaceutically acceptable salt thereof is provided herein.

[0058] In one embodiment, the compound of formula AA [ka] (In the formula, m=0, 1, or 2; n=0, 1, or 2; o=1 or 2; p=0, 1, 2, or 3; where: A is a 5- to 10-membered monocyclic or bicyclic heteroaryl or a C6-C 10 Monocyclic or is a bicyclic aryl; B is a 5- to 10-membered monocyclic or bicyclic heteroaryl or a C6-C 10 Monocyclic or is a bicyclic aryl; where: At least one R 6 is an ortho group relative to the bond connecting the B ring of formula AA to the NH(CO) group. It is; R 1and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl;CO(5- to 10-membered heteroaryl);CO 2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, N H2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, NHCOC1-C6 alk Kill, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl), NH CO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl, NHCOO CC1-C6 alkyl, NH-(C=NR 13 )NR 11 R 12 ,CONR 8 R 9 ,SCIENCE FICTION 5. SC1-C6 alkyl, S(O2)C1-C6 alkyl, S(O)C1-C6 alkyl Le, S(O2)NR 11 R 12 , C3-C7 cycloalkyl and 3- to 7-membered heterocyclo alkyl, Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R 2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituents are 1 to 3 hydroxy, halo, NR 8 R 9 or oxo and optionally independently and replaced; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from optionally independently substituted, wherein C1-C6 alkyl and C1-C6 alkoxy are Hydroxy, Halo, Oxo, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 optionally replaced by; R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, S(O2) C1-C6 alkyl, C3-C 10 Cycloalkyl and 3 C-C alkenyl; where R 6 and R 7 are hydroxy, halo, CN, oxo, and C1-C6 alkoxy groups, respectively. Kyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C ONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 membered Heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO(5 3- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCOC 1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl cycloalkyl), NHCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl , C6~C 10 aryloxy, and S(O2)C1-C6 alkyl; wherein R 6 or R 7 is replaced by C1 -C6 alkyl or C1-C6 alkoxy is one or more hydroxyl, C6-C 10 a Reel or NR 8 R 9 or R 6 or R 7 is a 5- to 7-membered carbocyclic ring or a complex containing one or two heteroatoms independently selected from oxygen, sulfur and nitrogen optionally fused to a ring; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from optionally substituted with one or more substituents independently selected from R 4 and R 5 each is independently selected from hydrogen and C1-C6 alkyl; R 10 is C1-C6 alkyl; R 8 and R 9 each occurrence is independently hydrogen, C1-C6 alkyl, (C=NR 13 )NR 11 R 12 , S(O2)C1-C6 alkyl, S(O2)NR 11 R 12 , C.O.R. 13 , CO2R 13 and CONR 11 R 12 where C1 is selected from -C6 alkyl is one or more of hydroxy, halo, C1-C6 alkoxy, C6-C 10 Aryl, 5- to 10-membered heteroaryl, C3-C7 cycloalkyl or 3- to 7-membered heteroaryl or R 8 and R 9 are the nitrogen atoms to which they are bonded. together with the nitrogen, optionally containing one or more heteroatoms in addition to the nitrogen to which they are attached. Form a 3- to 7-membered ring containing: R 13 is C1-C6 alkyl, C6-C 10 Aryl or 5- to 10-membered heteroaryl It is a rule; R 11 and R 12 Each occurrence of is independently selected from hydrogen and C1-C6 alkyl. Selected from kill; R 3 is hydrogen, cyano, hydroxy, C1-C6 alkoxy, C1-C6 alkyl, and Beauty [ka] wherein the C1-C2 alkylene group is optionally substituted with oxo; R 14 is hydrogen, C1-C6 alkyl, 5- to 10-membered monocyclic or bicyclic heteroaryl C6-C 10 monocyclic or bicyclic aryl, wherein each C1-C6 aryl alkyl, aryl, or heteroaryl is one or two R 6 Optionally and independently replaced by be; provided that the compound of formula AA is [ka] (not a compound selected from the group consisting of Compounds of; or a pharmaceutically acceptable salt thereof is provided herein.

[0059] In one embodiment, the compound of formula AA [ka] (In the formula, m=0, 1, or 2; n=0, 1, or 2; o=1 or 2; p=0, 1, 2, or 3; where: A is a 5- to 10-membered monocyclic or bicyclic heteroaryl or a C6-C 10 Monocyclic or is a bicyclic aryl; B is a 5-membered heteroaryl, a 7- to 10-membered monocyclic or bicyclic heteroaryl, or C 6~C 10 is a monocyclic or bicyclic aryl; where: At least one R 6 is an ortho group relative to the bond connecting the B ring of formula AA to the NH(CO) group. It is; R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl;CO(5- to 10-membered heteroaryl);CO 2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, N H2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, NHCOC1-C6 alk Kill, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl), NH CO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl, NHCOO CC1-C6 alkyl, NH-(C=NR 13 )NR 11 R 12 ,CONR 8 R 9 ,SCIENCE FICTION 5. SC1-C6 alkyl, S(O2)C1-C6 alkyl, S(O)C1-C6 alkyl Le, S(O2)NR 11 R 12 , C3-C7 cycloalkyl and 3- to 7-membered heterocyclo alkyl, Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R 2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituents are 1 to 3 hydroxy, halo, NR 8 R 9 or oxo and optionally independently and replaced; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from optionally independently substituted, wherein C1-C6 alkyl and C1-C6 alkoxy are Hydroxy, Halo, Oxo, NR 8 R 9, =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 optionally replaced by; R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, S(O2) C1-C6 alkyl, C3-C 10 Cycloalkyl and 3 C-C alkenyl; where R 6 and R 7 are hydroxy, halo, CN, oxo, and C1-C6 alkoxy groups, respectively. Kyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C ONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 membered Heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO(5 3- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCOC 1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl cycloalkyl), NHCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl , C6~C 10 aryloxy, and S(O2)C1-C6 alkyl; wherein R 6 or R 7 is replaced by C1 -C6 alkyl or C1-C6 alkoxy is one or more hydroxyl, C6-C 10 a Reel or NR 8 R 9 or R 6 or R 7 is a 5- to 7-membered carbocyclic ring or a complex containing one or two heteroatoms independently selected from oxygen, sulfur and nitrogen optionally fused to a ring; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from optionally substituted with one or more substituents independently selected from R 4 and R 5 each is independently selected from hydrogen and C1-C6 alkyl; R 10 is C1-C6 alkyl; R 8 and R 9 each occurrence is independently hydrogen, C1-C6 alkyl, (C=NR 13 )NR 11 R 12 , S(O2)C1-C6 alkyl, S(O2)NR 11 R 12 , C.O.R. 13 , CO2R 13 and CONR 11 R 12 where C1 is selected from -C6 alkyl is one or more of hydroxy, halo, C1-C6 alkoxy, C6-C 10 Aryl, 5- to 10-membered heteroaryl, C3-C7 cycloalkyl or 3- to 7-membered heteroaryl or R 8 and R 9 are the nitrogen atoms to which they are bonded. together with the nitrogen, optionally containing one or more heteroatoms in addition to the nitrogen to which they are attached. Form a 3- to 7-membered ring containing: R 13 is C1-C6 alkyl, C6-C 10 Aryl or 5- to 10-membered heteroaryl It is a rule; R 11 and R 12 Each occurrence of is independently selected from hydrogen and C1-C6 alkyl. Selected from kill; R 3 is hydrogen, cyano, hydroxy, C1-C6 alkoxy, C1-C6 alkyl, and Beauty [ka] wherein the C1-C2 alkylene group is optionally substituted with oxo; R 14 is hydrogen, C1-C6 alkyl, 5- to 10-membered monocyclic or bicyclic heteroaryl C6-C 10 monocyclic or bicyclic aryl, wherein each C1-C6 aryl alkyl, aryl, or heteroaryl is one or two R 6 Optionally and independently replaced by will be) Compounds of; or a pharmaceutically acceptable salt thereof is provided herein.

[0060] In certain embodiments, the variables shown in the formulas herein are as follows:

[0061] Variables m and n In some embodiments, m=0, 1, or 2.

[0062] In some embodiments, m=0 or 1.

[0063] In some embodiments, m=1 or 2.

[0064] In some embodiments, m=0 or 2.

[0065] In some embodiments, m=0.

[0066] In some embodiments, m=1.

[0067] In some embodiments, m=2.

[0068] In some embodiments, n=0, 1, or 2.

[0069] In some embodiments, n=0 or 1.

[0070] In some embodiments, n=1 or 2.

[0071] In some embodiments, n=0 or 2.

[0072] In one embodiment, n=0.

[0073] In one embodiment, n=1.

[0074] In some embodiments, n=2.

[0075] In some embodiments, m=0 and n=0.

[0076] In some embodiments, m=1 and n=0.

[0077] In some embodiments, m=1 and n=1.

[0078] Ring A and substitution on ring A In some embodiments, A is a 5- to 10-membered (eg, 5- to 6-membered) monocyclic or bicyclic Cyclic heteroaryl or C6-C 10 (e.g., C6) monocyclic or bicyclic aryl, For example, phenyl.

[0079] In some embodiments, A is a 5- to 10-membered (e.g., 5- to 6-membered) monocyclic or bicyclic ring. It is heteroaryl.

[0080] In some embodiments, A is a 5-membered heterocyclic group containing sulfur and optionally one or more nitrogen atoms. It is a teraryl.

[0081] In one embodiment, A is C6-C 10 It is a monocyclic or bicyclic aryl.

[0082] In some embodiments, A is one or two R 1 and optionally replaced by one or two R's 2 is phenyl optionally substituted with

[0083] In some embodiments, A is one or two R 1 and optionally replaced by one or two R's 2 is naphthyl optionally substituted with

[0084] In some embodiments, A is one or two R 1 and optionally replaced by one R 2 is furanyl optionally substituted with

[0085] In some embodiments, A is one R 1 and one or two R 2 is furanyl optionally substituted with

[0086] In some embodiments, A is one or two R 1 and optionally replaced by one or two R's 2 is thiophenyl optionally substituted with

[0087] In some embodiments, A is one or two R 1 and optionally replaced by one or two R's 2is oxazolyl optionally substituted with

[0088] In some embodiments, A is one or two R 1 and optionally replaced by one or two R's 2 is thiazolyl optionally substituted with

[0089] In some embodiments, A is a group consisting of two R 1 or two R 2 in and optionally substituted oxazolyl.

[0090] In some embodiments, A is a group consisting of two R 1 or two R 2 in Optionally substituted thiazolyl.

[0091] In some embodiments, A is one or two R 1 and optionally replaced by one or two R's 2 is pyrazolyl optionally substituted with

[0092] In some embodiments, A is one R 1 and one or two R 2 is pyrazolyl optionally substituted with

[0093] In some embodiments, A is one or two R 1 and optionally replaced by one R 2 is pyrazolyl optionally substituted with

[0094] In some embodiments, A is one or two R 1 and optionally replaced by one or two R's 2 is pyridyl optionally substituted with

[0095] In some embodiments, A is one or two R 1 and optionally replaced by one or two R's 2 is indazolyl optionally substituted with

[0096] In some embodiments, A is one R 1 and one R 2 Optionally with It is a substituted phenyl.

[0097] In some embodiments, A is one R 1 and one R 2 Optionally with It is a substituted naphthyl.

[0098] In some embodiments, A is one R 1 and one R 2 Optionally with It is a substituted furanyl.

[0099] In some embodiments, A is one R 1 and one R 2 Optionally with It is a substituted thiophenyl.

[0100] In some embodiments, A is one R 1 and one R 2 Optionally with It is a substituted oxazolyl.

[0101] In some embodiments, A is one R 1 and one R 2 Optionally with It is a substituted thiazolyl.

[0102] In some embodiments, A is one R 1 and one R2 Optionally with It is a substituted pyrazolyl.

[0103] In some embodiments, A is one R 1 and one R 2 Optionally with It is a substituted pyridyl.

[0104] In some embodiments, A is one R 1 and one R 2 in and optionally substituted indazolyl.

[0105] In some embodiments, A is one R 1 and one R 2 Replaced by It is Venil.

[0106] In some embodiments, A is one R 1 and one R 2 Replaced by This is Ranil.

[0107] In some embodiments, A is one R 1 and one R 2 Chi replaced by It is phenyl.

[0108] In some embodiments, A is one R 1 and one R 2 Replaced by It is oxazolyl.

[0109] In some embodiments, A is one R 1 and one R 2 Chi replaced by It is azolyl.

[0110] In some embodiments, A is one R 1and one R 2 Pi replaced by It's Lazoryl.

[0111] In some embodiments, A is one R 1 and one R 2 Pi replaced by It's Rizil.

[0112] In some embodiments, A is phenyl, m is 0 or 1, and n is 0, 1, Or 2.

[0113] In one embodiment, A is furanyl, m is 0 or 1, and n is 0, 1, Or 2.

[0114] In some embodiments, A is thiophenyl, m is 0 or 1, and n is 0, It is either 1 or 2.

[0115] In one embodiment, A is oxazolyl, m is 0 or 1, and n is 0, It is either 1 or 2.

[0116] In one embodiment, A is thiazolyl, m is 0 or 1, and n is 0, 1 , or 2.

[0117] In one embodiment, A is pyrazolyl, m is 0 or 1, and n is 0, 1 , or 2.

[0118] In some embodiments, A is pyridyl, m is 0 or 1, and n is 0, 1, Or 2.

[0119] In one embodiment, A is indazolyl, m is 0 or 1, and n is 0, It is either 1 or 2.

[0120] In some embodiments, A is phenyl, m is 0, and n is 0 or 1.

[0121] In some embodiments, A is furanyl, m is 0, and n is 0 or 1.

[0122] In some embodiments, A is thiophenyl, m is 0, and n is 0 or 1. do.

[0123] In one embodiment, A is oxazolyl, m is 0, and n is 0 or 1. do.

[0124] In some embodiments, A is thiazolyl, m is 0, and n is 0 or 1. .

[0125] In some embodiments, A is pyrazolyl, m is 0, and n is 0 or 1. .

[0126] In some embodiments, A is pyridyl, m is 0, and n is 0 or 1.

[0127] In certain embodiments, A is optionally as disclosed herein below. is one of the rings disclosed herein below, which is substituted, and in each case is represented by a wavy line [ka] The bond shown to be broken by the formula AA is A, which is S(O)(NR 3 R 3 )= Linked to N moiety.

[0128] In one embodiment, optionally substituted ring A( [ka] )teeth, [ka] is.

[0129] In one embodiment, optionally substituted ring A is [ka] is.

[0130] In one embodiment, optionally substituted ring A is [ka] is.

[0131] In one embodiment, optionally substituted ring A is [ka] is.

[0132] In one embodiment, optionally substituted ring A is [ka] is.

[0133] In one embodiment, optionally substituted ring A is [ka] is.

[0134] In one embodiment, optionally substituted ring A is [ka] is.

[0135] In one embodiment, optionally substituted ring A is [ka] is.

[0136] In one embodiment, optionally substituted ring A is [ka] is.

[0137] In one embodiment, optionally substituted ring A is [ka] is.

[0138] In one embodiment, optionally substituted ring A is [ka] is.

[0139] In one embodiment, optionally substituted ring A is [ka] is.

[0140] In one embodiment, optionally substituted ring A is [ka] is.

[0141] In one embodiment, optionally substituted ring A is [ka] is.

[0142] In one embodiment, optionally substituted ring A is [ka] is.

[0143] In one embodiment, optionally substituted ring A is [ka] is.

[0144] In one embodiment, optionally substituted ring A is [ka] is.

[0145] In one embodiment, optionally substituted ring A is [ka] is.

[0146] In one embodiment, optionally substituted ring A is [ka] is.

[0147] In one embodiment, optionally substituted ring A is [ka] is.

[0148] In one embodiment, optionally substituted ring A is [ka] is.

[0149] In one embodiment, optionally substituted ring A is [ka] is.

[0150] In one embodiment, optionally substituted ring A is [ka] is.

[0151] In one embodiment, optionally substituted ring A is [ka] is.

[0152] In one embodiment, optionally substituted ring A is [ka] is.

[0153] In one embodiment, optionally substituted ring A is [ka] is.

[0154] In one embodiment, optionally substituted ring A is [ka] is.

[0155] In one embodiment, optionally substituted ring A is [ka] is.

[0156] In one embodiment, optionally substituted ring A is [ka] is.

[0157] In one embodiment, optionally substituted ring A is [ka] is.

[0158] In one embodiment, optionally substituted ring A is [ka] is.

[0159] In one embodiment, optionally substituted ring A is [ka] is.

[0160] In one embodiment, optionally substituted ring A is [ka] is.

[0161] In one embodiment, optionally substituted ring A is [ka] is.

[0162] In one embodiment, optionally substituted ring A is [ka] is.

[0163] In one embodiment, optionally substituted ring A is [ka] is.

[0164] In one embodiment, optionally substituted ring A is [ka] is.

[0165] In one embodiment, optionally substituted ring A is [ka] is.

[0166] In one embodiment, optionally substituted ring A is [ka] is.

[0167] In one embodiment, optionally substituted ring A is [ka] is.

[0168] In one embodiment, optionally substituted ring A is [ka] is.

[0169] In one embodiment, optionally substituted ring A is [ka] is.

[0170] In one embodiment, optionally substituted ring A is [ka] is.

[0171] In one embodiment, optionally substituted ring A is [ka] is.

[0172] In one embodiment, optionally substituted ring A is [ka] is.

[0173] In one embodiment, optionally substituted ring A is [ka] is.

[0174] In one embodiment, optionally substituted ring A is [ka] is.

[0175] In one embodiment, optionally substituted ring A is [ka] is.

[0176] In one embodiment, optionally substituted ring A is [ka] is.

[0177] In one embodiment, optionally substituted ring A is [ka] is.

[0178] In one embodiment, optionally substituted ring A is [ka] is.

[0179] In one embodiment, optionally substituted ring A is [ka] is.

[0180] In one embodiment, optionally substituted ring A is [ka] is.

[0181] In one embodiment, optionally substituted ring A is [ka] is.

[0182] In one embodiment, optionally substituted ring A is [ka] is.

[0183] In one embodiment, optionally substituted ring A is [ka] is.

[0184] In one embodiment, optionally substituted ring A is [ka] is.

[0185] In one embodiment, optionally substituted ring A is [ka] is.

[0186] In one embodiment, optionally substituted ring A is [ka] is.

[0187] In one embodiment, optionally substituted ring A is [ka] is.

[0188] In one embodiment, optionally substituted ring A is [ka] is.

[0189] In one embodiment, optionally substituted ring A is [ka] is.

[0190] In one embodiment, optionally substituted ring A is [ka] is.

[0191] In one embodiment, optionally substituted ring A is [ka] is.

[0192] In one embodiment, optionally substituted ring A is [ka] is.

[0193] In one embodiment, optionally substituted ring A is [ka] is.

[0194] In one embodiment, optionally substituted ring A is [ka] is.

[0195] In one embodiment, optionally substituted ring A is [ka] is.

[0196] In one embodiment, optionally substituted ring A is [ka] is.

[0197] In one embodiment, optionally substituted ring A is [ka] is.

[0198] In one embodiment, optionally substituted ring A is [ka] is.

[0199] In one embodiment, optionally substituted ring A is [ka] is.

[0200] In one embodiment, optionally substituted ring A is [ka] is.

[0201] In one embodiment, optionally substituted ring A is [ka] is.

[0202] In one embodiment, optionally substituted ring A is [ka] is.

[0203] In one embodiment, optionally substituted ring A is [ka] is.

[0204] In one embodiment, optionally substituted ring A is [ka] is.

[0205] In one embodiment, optionally substituted ring A is [ka] is.

[0206] In one embodiment, optionally substituted ring A is [ka] is.

[0207] In one embodiment, optionally substituted ring A is [ka] is.

[0208] In one embodiment, optionally substituted ring A is [ka] is.

[0209] base R 1 and R 2 In one embodiment, R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl, CO (5- to 10-membered heteroaryl), CO 2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, N H2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5 , SC1~C6 alkyl, S(O2)C1~C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl, C3-C7 cycloalkyl and 3- to 7-membered heterocycloalkyl Selected from Rukill, C1-C6 alkyl, C1-C6 haloalkyl, C3-C7 cycloalkyl and 3-membered alkyl 7-membered heterocycloalkyl includes hydroxy, halo, CN, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5- to 10-membered hetero Aryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO(5-membered to 1 and OCO (3- to 7-membered heterocycloalkyl), optionally substituted with one or more substituents selected from the group consisting of: where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R 2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituents are 1 to 3 hydroxy, halo, NR 8 R 9 or oxo and optionally independently and replaced; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl and 5- to 10-membered Heteroaryl is independently selected from halo, C1-C6 alkyl, and C1-C6 alkyl. optionally substituted with one or more selected substituents; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from selectively independently substituted; In one embodiment, R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl;CO(5- to 10-membered heteroaryl);CO 2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, N H2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5 , SC1~C6 alkyl, S(O2)C1~C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl, C3-C7 cycloalkyl and 3- to 7-membered heterocycloalkyl Selected from Rukill, Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R 2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituents are 1 to 3 hydroxy, halo, NR 8 R 9 or oxo and optionally independently and replaced; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from selectively independently substituted; In one embodiment, R 1 and R 2 are each independently C1-C6 haloalkyl, C1-C6 alkoxy , C1-C6 haloalkoxy, halo, CN, NO2, COC1-C6 alkyl, CO-C 6~C 10 Aryl, CO (5- to 10-membered heteroaryl), CO2C1-C6 alkyl , CO2C3~C8 cycloalkyl, OCOC1~C6 alkyl, OCOC6~C 10 a Aryl, OCO (5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloaryl) Kill), C6~C 10 Aryl, 5- to 10-membered heteroaryl, NH2, NHC1 to C6 Alkyl, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5, SC1~C6 Alky S(O2)C1-C6 alkyl, S(O2)NR 11 R 12 , S(O)C1~C6A alkyl, C3-C7 cycloalkyl, and 3- to 7-membered heterocycloalkyl; Here, C3 to C7 cycloalkyl, C1 to C6 haloalkyl, and 3- to 7-membered heteroalkyl are Cycloalkyl is hydroxy, halo, CN, oxo, C1-C6 alkyl, C1-C6 Alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, CONR 8 R 9 , 3 1- to 7-membered heterocycloalkyl, C6-C 10 aryl, 5- to 10-membered heteroaryl, OCOC1~C6 alkyl, OCOC6~C 10 Aryl, OCO (5-10 membered heterocyclic Aryl), OCO(3- to 7-membered heterocycloalkyl), NHCOC1-C6 alkyl , NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkynyl, respectively optionally substituted with one or more independently selected substituents; where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R 2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituents are 1 to 3 hydroxy, halo, NR 8 R 9 or oxo and optionally independently and replaced; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from are optionally independently substituted.

[0210] In one embodiment, R 1 and R 2 are each independently C1-C6 alkyl, halo, CN, NO2, CO C1-C6 alkyl, CO-C6-C 10 Aryl, CO(5- to 10-membered heteroaryl ), CO2C1-C6 alkyl, OCOC1-C6 alkyl, OCOC6-C 10 Ally OCO(5- to 10-membered heteroaryl), OCO(3- to 7-membered heterocycloalkyl) ), C6~C 10 Aryl, 5- to 10-membered heteroaryl, NH2, NHC1-C6 aryl Kyl, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5, SC1 to C6 alkyl, S(O2)C1-C6 alkyl, S(O2)NR 11 R 12 , S(O)C1~C6 alkyl C3-C7 cycloalkyl and 3- to 7-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R 2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituents are 1 to 3 hydroxy, halo, NR 8 R 9 or oxo and optionally independently and replaced; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from are optionally independently substituted.

[0211] In one embodiment, R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl, CO (5- to 10-membered heteroaryl), CO 2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, N H2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CONR 8 R 9, SF5 , SC1~C6 alkyl, S(O2)C1~C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl, C3-C7 cycloalkyl and 3- to 7-membered heterocycloalkyl Selected from Rukill, Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; where R 1 or R 2 C3-C7 cycloalkyl or R 1 or R 2 3 members~ Each C1-C6 alkyl substituent and each C1-C6 alkoxy substituent of a 7-membered heterocycloalkyl The substituent is further optionally substituted independently with 1 to 3 hydroxy, halo, or oxo. Re; wherein 3- to 7-membered heterocycloalkyl, C6-C 10Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from are optionally independently substituted.

[0212] In one embodiment, R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl, CO (5- to 10-membered heteroaryl), CO 2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, N H2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5 , SC1~C6 alkyl, S(O2)C1~C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl, C3-C7 cycloalkyl and 3- to 7-membered heterocycloalkyl Selected from Rukill, Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl do.

[0213] In one embodiment, R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl, CO (5- to 10-membered heteroaryl), CO 2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, N H2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5 , SC1~C6 alkyl, S(O2)C1~C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl, C3-C7 cycloalkyl and 3- to 7-membered heterocycloalkyl Selected from Rukill, Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl are each unsubstituted; or R on the adjacent atom 1 and R 2 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from selectively independently substituted; In one embodiment, R 1 and R 2 are each independently C1-C6 alkyl, halo, CN, COC1-C 6 alkyl, CO2C1-C6 alkyl, C6-C 10 Aryl, S(O)C1-C6 alkyl, 5- to 10-membered heteroaryl, and 3- to 7-membered heterocycloalkyl. R, Here, C1-C6 alkyl and 3- to 7-membered heterocycloalkyl include hydroxy and and optionally substituted with one or more substituents each independently selected from oxo.

[0214] In one embodiment, m=1; n=0; R 1 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1 ~C6 haloalkoxy, halo, CN, NO2, COC1~C6 alkyl, CO-C6~C 10 Aryl, CO (5- to 10-membered heteroaryl), CO2C1-C6 alkyl, CO 2C3~C8 cycloalkyl, OCOC1~C6 alkyl, OCOC6~C 10 Aryl , OCO(5- to 10-membered heteroaryl), OCO(3- to 7-membered heterocycloalkyl) , C6~C 10 Aryl, 5- to 10-membered heteroaryl, NH2, NHC1-C6 alkyl Ru, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5, SC1~C6 alkyl, S (O2)C1-C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl , C3-C7 cycloalkyl, and 3- to 7-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl do.

[0215] In one embodiment, m=1; n=0; R 1 C1-C6 alkyl, halo, CN, COC1-C6 alkyl, CO2C1-C 6 alkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl, S(O)C1-C6 alkyl, and 3- to 7-membered heterocycloalkyl; Here, C1-C6 alkyl and 3- to 7-membered heterocycloalkyl include hydroxy and and optionally substituted with one or more substituents each independently selected from oxo.

[0216] In some embodiments, m=1; n=1; R 1 and R 2 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO-C6~C 10 Aryl, CO (5- to 10-membered heteroaryl), CO 2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, N H2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5 , SC1~C6 alkyl, S(O2)C1~C6 alkyl, S(O2)NR 11 R 12 , S(O)C1-C6 alkyl, C3-C7 cycloalkyl and 3- to 7-membered heterocycloalkyl Selected from Rukill, Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; In some embodiments, m=1; n=1; R 1 and R 2 are each independently C1-C6 alkyl, halo, CN, COC1-C 6 alkyl, CO2C1-C6 alkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl S(O)aryl, S(O)C1-C6 alkyl, and 3- to 7-membered heterocycloalkyl R, Here, C1-C6 alkyl and 3- to 7-membered heterocycloalkyl include hydroxy and and optionally substituted with one or more substituents each independently selected from oxo.

[0217] In some embodiments, m=1; n=1; R 1 and R 2 are on adjacent atoms, and together with the atoms connecting them, form C4~ C8 carbocyclic ring or containing 1 or 2 heteroatoms independently selected from O, N, and S and forming a 5- to 8-membered heterocyclic ring, wherein the carbocyclic or heterocyclic ring is substituted with hydroxy, halo, oxy, or the like. SO, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1 ~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 1 independently selected from Optionally substituted independently with one or more substituents.

[0218] In some embodiments, m=1; n=1; R 1 and R 2 are on adjacent atoms and, together with the atoms connecting them, form the C6 carbon atom. a heterocyclic ring or a 5-membered ring containing one or two heteroatoms independently selected from O, N, and S; forming a 1- to 6-membered heterocyclic ring, wherein the carbocyclic or heterocyclic ring is hydroxy, halo, oxo, C 1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 Alkyl, C6-C 10 Aryl, and CONR 8 R 9 one or more independently selected from is optionally independently substituted with a substituent of

[0219] In some embodiments, m=1; n=1; R 1 and R 2 are on adjacent atoms and, together with the atoms connecting them, form the C5 carbon atom. a heterocyclic ring or a 5-membered ring containing one or two heteroatoms independently selected from O, N, and S; forming a 1- to 6-membered heterocyclic ring, wherein the carbocyclic or heterocyclic ring is hydroxy, halo, oxo, C 1-C6 alkyl, C1-C6 alkoxy, COOC1-C6 alkyl, C6-C 10 a Reel and CONR 8 R 9 and optionally with one or more substituents independently selected from It is replaced by

[0220] In some embodiments, m=1; n=1; R 1 and R 2 are on adjacent atoms, and together with the atoms connecting them, form C4~ C8 carbocyclic ring or containing 1 or 2 heteroatoms independently selected from O, N, and S and forming a 5- to 8-membered heterocyclic ring, wherein the carbocyclic or heterocyclic ring is unsubstituted.

[0221] In particular embodiments where m=1 and n=0: In one embodiment, R 1is a C1 optionally substituted with one or more hydroxy ~C6 alkyl.

[0222] In one embodiment, R 1 is 1-hydroxy-2-methylpropan-2-yl .

[0223] In one embodiment, R 1 is 2-hydroxyethyl.

[0224] In one embodiment, R 1 is C1-C6 alkyl.

[0225] In one embodiment, R 1 is methyl.

[0226] In one embodiment, R 1 is isopropyl.

[0227] In one embodiment, R 1 is isopropyl.

[0228] In one embodiment, R 1 is substituted with hydroxy at the carbon directly connected to ring A It is a C1-C6 alkyl.

[0229] In one embodiment, R 1 is 2-hydroxy-2-propyl.

[0230] In one embodiment, R 1 is hydroxymethyl.

[0231] In one embodiment, R 1 is 1-hydroxyethyl.

[0232] In one embodiment, R 1 is 1-hydroxy-2-propyl.

[0233] In one embodiment, R 1 is a C1-C6 alkyl group substituted with two or more hydroxy groups. It's a kill.

[0234] In one embodiment, R 1 is a C1-C6 alkyl group substituted with two or more hydroxy groups. wherein one of the two or more hydroxy groups is a carbon atom directly linked to ring A. are bonded to the element.

[0235] In one embodiment, R 1 is 1,2-dihydroxy-prop-2-yl.

[0236] In one embodiment, R 1 is a C3 optionally substituted with one or more hydroxy ~C7 cycloalkyl.

[0237] In one embodiment, R 1 is a C3-C7 cycloalkyl.

[0238] In one embodiment, R 1 is substituted with hydroxy at the carbon directly connected to ring A is a C3-C7 cycloalkyl.

[0239] In one embodiment, R 1 is 1-hydroxy-1-cyclopropyl.

[0240] In one embodiment, R 1 is 1-hydroxy-1-cyclobutyl.

[0241] In one embodiment, R 1 is 1-hydroxy-1-cyclopentyl.

[0242] In one embodiment, R 1 is 1-hydroxy-1-cyclohexyl.

[0243] In one embodiment, R 1 is a 3-membered alkyl group optionally substituted with one or more hydroxy groups 1 to 7-membered heterocycloalkyl.

[0244] In one embodiment, R 1 is a 3- to 7-membered heterocycloalkyl.

[0245] In one embodiment, R 1 is morpholinyl (e.g., 1-morpholinyl).

[0246] In one embodiment, R 1 is 1,3-dioxolan-2-yl.

[0247] In one embodiment, R 1 is optionally substituted with one or more C1-C6 alkyl is a 3- to 7-membered heterocycloalkyl.

[0248] In one embodiment, R 1 is 1-methylpyrrolidin-2-yl.

[0249] In one embodiment, R 1 is substituted with hydroxy at the carbon directly connected to ring A is a 3- to 7-membered heterocycloalkyl.

[0250] In one embodiment, R 1 is a C1-C optionally substituted with one or more oxo 6 alkyl.

[0251] In one embodiment, R 1 is COCH3.

[0252] In one embodiment, R 1 is COCH2CH3.

[0253] In one embodiment, R 1 is a C3-C optionally substituted with one or more oxo 7 cycloalkyl.

[0254] In one embodiment, R 1 is a 3- to 7-membered alkyl group optionally substituted with one or more oxo groups. It is a membered heterocycloalkyl.

[0255] In one embodiment, R 1 is optionally substituted with one or more C1-C6 alkoxy It is a C1-C6 alkyl.

[0256] In one embodiment, R 1 is 2-methoxy-2-propyl.

[0257] In one embodiment, R 1 is methoxymethyl.

[0258] In one embodiment, R 1 is optionally substituted with one or more C1-C6 alkoxy is a C3-C7 cycloalkyl.

[0259] In one embodiment, R 1 is optionally substituted with one or more C1-C6 alkoxy is a 3- to 7-membered heterocycloalkyl.

[0260] In one embodiment, R 1 is one or more NR 8 R 9 C1 optionally substituted with ~C6 alkyl.

[0261] In one embodiment, R 1 is NR at the carbon directly connected to ring A 8 R 9 Replace with It is a C1-C6 alkyl.

[0262] In one embodiment, R 1 is (methylamino)methyl.

[0263] In one embodiment, R 1 is (dimethylamino)methyl.

[0264] In one embodiment, R 1 is aminomethyl.

[0265] In one embodiment, R 1 is N-methylacetamidomethyl.

[0266] In one embodiment, R 1 is 1-(dimethylamino)eth-1-yl.

[0267] In one embodiment, R 1 is 2-(dimethylamino)prop-2-yl.

[0268] In one embodiment, R 1 (2-Methoxy-eth-1-yl)(methyl)aminomethyl It's chill.

[0269] In one embodiment, R 1 is (methyl)(acetyl)aminomethyl.

[0270] In one embodiment, R 1 is (methyl)(cyclopropylmethyl)aminomethyl do.

[0271] In one embodiment, R 1 (methyl)(2,2-difluoroeth-1-yl)amine It is methyl.

[0272] In one embodiment, R 1 is one or more NR8 R 9 C3 optionally substituted with ~C7 cycloalkyl.

[0273] In one embodiment, R 1 is one or more NR 8 R 9 3-membered optionally substituted with 1 to 7-membered heterocycloalkyl.

[0274] In one embodiment, R 1 is a C1 optionally substituted with one or more hydroxy ~C6 haloalkyl.

[0275] In one embodiment, R 1 is C1-C6 alkoxy.

[0276] In one embodiment, R 1 is C1-C6 haloalkoxy.

[0277] In one embodiment, R 1 is optionally substituted with a 3- to 7-membered heterocycloalkyl wherein 3- to 7-membered heterocycloalkyl is a C1-C6 alkyl group as defined herein. Further optional substitutions are made as defined elsewhere in this document.

[0278] In one embodiment, R 1 is pyrrolidinylmethyl (e.g., pyrrolidin-1-ylmethyl) Chill).

[0279] In one embodiment, R 1 is an optionally substituted pyrrolidinylmethyl (e.g. , 3,3-difluoropyrrolidin-1-ylmethyl).

[0280] In one embodiment, R 1is azetidinylmethyl (e.g., azetidin-1-ylmethyl) Chill).

[0281] In one embodiment, R 1 is an optionally substituted azetidinylmethyl (e.g. , 3-methoxyazetidin-1-ylmethyl).

[0282] In one embodiment, R 1 is morpholinylmethyl (e.g., morpholin-4-ylmethyl) Chill).

[0283] In one embodiment, R 1 is a halo.

[0284] In one embodiment, R 1 is fluoro.

[0285] In one embodiment, R 1 is chloro.

[0286] In one embodiment, R 1 is CN.

[0287] In one embodiment, R 1 is NO2.

[0288] In one embodiment, R 1 is COC1-C6 alkyl.

[0289] In one embodiment, R 1 CO-C6~C 10 It is aryl.

[0290] In one embodiment, R 1 is CO(5- to 10-membered heteroaryl).

[0291] In one embodiment, R 1 is CO2C1-C6 alkyl.

[0292] In one embodiment, R 1 is CO2C3-C8 cycloalkyl.

[0293] In one embodiment, R 1 is OCOC1-C6 alkyl.

[0294] In one embodiment, R 1 OCOC6~C 10 It is aryl.

[0295] In one embodiment, R 1 is OCO (5- to 10-membered heteroaryl).

[0296] In one embodiment, R 1 is OCO (3- to 7-membered heterocycloalkyl).

[0297] In one embodiment, R 1 is C6~C 10 It is aryl.

[0298] In one embodiment, R 1 is phenyl.

[0299] In one embodiment, R 1 is a 5- to 10-membered heteroaryl.

[0300] In one embodiment, R 1 is pyridyl (e.g., 4-pyridyl).

[0301] In one embodiment, R 1 is pyrazolyl (e.g., 1-pyrazolyl).

[0302] In one embodiment, R 1 is NH2.

[0303] In one embodiment, R 1 is NHC1-C6 alkyl.

[0304] In one embodiment, R 1 is N(C1-C6 alkyl)2.

[0305] In one embodiment, R 1 CONR 8 R 9 is.

[0306] In one embodiment, R 1 is SF5.

[0307] In one embodiment, R 1 is SC1-C6 alkyl, In one embodiment, R 1 is S(O2)C1-C6 alkyl.

[0308] In one embodiment, R 1 is S(O2)CH3.

[0309] In one embodiment, R 1 is S(O2)NR 11 R 12 is.

[0310] In one embodiment, R 1 is S(O2)N(CH3)2.

[0311] In one embodiment, R 1 is S(O)C1-C6 alkyl.

[0312] In one embodiment, R 1 is S(O)CH3.

[0313] In one embodiment, R 1 is attached to a carbon of the aryl ring A.

[0314] In one embodiment, R 1 is attached to a carbon of the heteroaryl ring A.

[0315] In one embodiment, R 1 is attached to the nitrogen of the heteroaryl ring A.

[0316] In particular embodiments where m=1 and n=1: In one embodiment, R 1 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 2 is a C1- optionally substituted with one or more hydroxy It is a C6 alkyl.

[0317] In one embodiment, R 1 is 1-hydroxy-2-methylpropan-2-yl , R 2 is methyl.

[0318] In one embodiment, R 1 is 2-hydroxy-2-propyl, and R 2 is methyl be.

[0319] In one embodiment, R 1 is 2-hydroxy-2-propyl, and R 2 is isopropyl It's a pill.

[0320] In one embodiment, R 1 is 2-hydroxy-2-propyl, and R 2 2-Hydro It is 2-propyloxy.

[0321] In one embodiment, R 1 is 2-hydroxy-2-propyl, and R 2 1-Hido It is oxyethyl.

[0322] In one embodiment, R 1 is hydroxymethyl and R 2 is methyl.

[0323] In one embodiment, R 1 is 1-hydroxyethyl, and R 2 is methyl.

[0324] In one embodiment, R 1 is 2-hydroxyethyl, and R 2 is methyl.

[0325] In one embodiment, R 1 is 1-hydroxy-2-propyl, and R 2 is methyl be.

[0326] In one embodiment, R 1 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 2 is C6~C 10 It is aryl.

[0327] In one embodiment, R 1 is 2-hydroxy-2-propyl, and R 2 is phenyl is.

[0328] In one embodiment, R 1 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 2 is a 5- to 10-membered heteroaryl.

[0329] In one embodiment, R 1 is 2-hydroxy-2-propyl, and R 2 is pyridyl is.

[0330] In one embodiment, R 1 is 2-hydroxy-2-propyl, and R 2 Hapirazori It is.

[0331] In one embodiment, R1 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 2 is SF5.

[0332] In one embodiment, R 1 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 2 is SC1-C6 alkyl, In one embodiment, R 1 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 2 is S(O2)C1-C6 alkyl.

[0333] In one embodiment, R 1 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 2 is S(O2)CH3.

[0334] In one embodiment, R 1 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 2 is a halo.

[0335] In one embodiment, R 1 is 2-hydroxy-2-propyl, and R 2 is Chloro be.

[0336] In one embodiment, R 1 is 2-hydroxy-2-propyl, and R 2 Is Fluoro is.

[0337] In one embodiment, R 1 is a C3 optionally substituted with one or more hydroxy ~C7 cycloalkyl, and R 2is C1-C6 alkyl.

[0338] In one embodiment, R 1 is 1-hydroxy-1-cyclopropyl, and R 2 Hame It's chill.

[0339] In one embodiment, R 1 is 1-hydroxy-1-cyclobutyl, and R 2 Hamechi It is.

[0340] In one embodiment, R 1 is 1-hydroxy-1-cyclopentyl and R 2 Hame It's chill.

[0341] In one embodiment, R 1 is 1-hydroxy-1-cyclohexyl, and R 2 Hame It's chill.

[0342] In one embodiment, R 1 is a 3-membered alkyl group optionally substituted with one or more hydroxy groups 7-membered heterocycloalkyl, and R 2 is C1-C6 alkyl.

[0343] In one embodiment, R 1 is morpholinyl and R 2 is methyl.

[0344] In one embodiment, R 1 is 1,3-dioxolan-2-yl and R 2 is methyl is.

[0345] In one embodiment, R 1 is a 3-membered alkyl group optionally substituted with one or more hydroxy groups 7-membered heterocycloalkyl, and R 2 is a halo.

[0346] In one embodiment, R 1 is 1,3-dioxolan-2-yl and R 2 Full Auto It is Ro.

[0347] In one embodiment, R 1 is 1,3-dioxolan-2-yl and R 2 is Chloro is.

[0348] In one embodiment, R 1 is a C1-C optionally substituted with one or more oxo 6 alkyl, and R 2 is methyl.

[0349] In one embodiment, R 1 is COCH3 and R 2 is methyl.

[0350] In one embodiment, R 1 is optionally substituted with one or more C1-C6 alkoxy is a C1-C6 alkyl group, and R 2 is C1-C6 alkyl.

[0351] In one embodiment, R 1 is 2-methoxy-2-propyl, and R 2 is methyl do.

[0352] In one embodiment, R 1 is one or more NR 8 R 9 C1 optionally substituted with ~C6 alkyl, and R 2 is C1-C6 alkyl.

[0353] In one embodiment, R 1 is (dimethylamino)methyl, and R 2 is methyl .

[0354] In one embodiment, R 1 is one or more NR 8 R 9 C1 optionally substituted with ~C6 alkyl, and R 2 is a halo.

[0355] In one embodiment, R 1 is (dimethylamino)methyl, and R 2 is fluoro do.

[0356] In one embodiment, R 1 is (dimethylamino)methyl, and R 2 is fluoro do.

[0357] In one embodiment, R 1 is (methylamino)methyl, and R 2 is fluoro .

[0358] In one embodiment, R 1 is aminomethyl, and R 2 is fluoro.

[0359] In one embodiment, R 1 is C1-C6 alkyl, and R 2 is C1-C6 alkyl is.

[0360] In one embodiment, R 1 is methyl and R 2 is methyl.

[0361] In one embodiment, R 2 is 1-hydroxy-2-methylpropan-2-yl , R 1 is methyl.

[0362] In one embodiment, R 2 is 2-hydroxy-2-propyl, and R 1 is methyl be.

[0363] In one embodiment, R 2 is 2-hydroxy-2-propyl, and R 1 is isopropyl It's a pill.

[0364] In one embodiment, R 2 is 2-hydroxy-2-propyl, and R 1 1-Hido It is oxyethyl.

[0365] In one embodiment, R 2 is hydroxymethyl and R 1 is methyl.

[0366] In one embodiment, R 2 is 1-hydroxyethyl, and R 1 is methyl.

[0367] In one embodiment, R 2 is 2-hydroxyethyl, and R 1 is methyl.

[0368] In one embodiment, R 2 is 1-hydroxy-2-propyl, and R 1 is methyl be.

[0369] In one embodiment, R 2 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 1 is C6~C 10 It is aryl.

[0370] In one embodiment, R 2 is 2-hydroxy-2-propyl, and R 1 is phenyl is.

[0371] In one embodiment, R 2 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 1 is a 5- to 10-membered heteroaryl.

[0372] In one embodiment, R 2 is 2-hydroxy-2-propyl, and R 1 is pyridyl is.

[0373] In one embodiment, R 2 is 2-hydroxy-2-propyl, and R 1 Hapirazori It is.

[0374] In one embodiment, R 2 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 1 is SF5.

[0375] In one embodiment, R 2 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 1 is SC1-C6 alkyl.

[0376] In one embodiment, R 2 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 1 is S(O2)C1-C6 alkyl.

[0377] In one embodiment, R 2 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 1 is S(O2)CH3.

[0378] In one embodiment, R 2 is a C1 optionally substituted with one or more hydroxy ~C6 alkyl, and R 1 is a halo.

[0379] In one embodiment, R 2 is 2-hydroxy-2-propyl, and R 1 is Chloro be.

[0380] In one embodiment, R 2 is 2-hydroxy-2-propyl, and R 1 Is Fluoro is.

[0381] In one embodiment, R 2 is a C3 optionally substituted with one or more hydroxy ~C7 cycloalkyl, and R 1 is C1-C6 alkyl.

[0382] In one embodiment, R 2 is 1-hydroxy-1-cyclopropyl, and R 1 Hame It's chill.

[0383] In one embodiment, R 2 is 1-hydroxy-1-cyclobutyl, and R 1 Hamechi It is.

[0384] In one embodiment, R 2 is 1-hydroxy-1-cyclopentyl and R 1 Hame It's chill.

[0385] In one embodiment, R 2 is 1-hydroxy-1-cyclohexyl, and R 1 Hame It's chill.

[0386] In one embodiment, R 2 is a 3-membered alkyl group optionally substituted with one or more hydroxy groups 7-membered heterocycloalkyl, and R 1 is C1-C6 alkyl.

[0387] In one embodiment, R 2 is morpholinyl and R 1 is methyl.

[0388] In one embodiment, R 2 is 1,3-dioxolan-2-yl and R 1 is methyl is.

[0389] In one embodiment, R 2 is a 3-membered alkyl group optionally substituted with one or more hydroxy groups 7-membered heterocycloalkyl, and R 1 is a halo.

[0390] In one embodiment, R 2 is 1,3-dioxolan-2-yl and R 1 Full Auto It is Ro.

[0391] In one embodiment, R 2 is 1,3-dioxolan-2-yl and R 1 is Chloro is.

[0392] In one embodiment, R 2 is a C1-C optionally substituted with one or more oxo 6 alkyl, and R 1 is methyl.

[0393] In one embodiment, R 2 is COCH3 and R 1 is methyl.

[0394] In one embodiment, R2 is optionally substituted with one or more C1-C6 alkoxy is a C1-C6 alkyl group, and R 1 is C1-C6 alkyl.

[0395] In one embodiment, R 2 is 2-methoxy-2-propyl, and R 1 is methyl do.

[0396] In one embodiment, R 2 is one or more NR 8 R 9 C1 optionally substituted with ~C6 alkyl, and R 1 is C1-C6 alkyl.

[0397] In one embodiment, R 2 is (dimethylamino)methyl, and R 1 is methyl .

[0398] In one embodiment, R 2 is one or more NR 8 R 9 C1 optionally substituted with ~C6 alkyl, and R 1 is a halo.

[0399] In one embodiment, R 2 is (dimethylamino)methyl, and R 1 is fluoro do.

[0400] In one embodiment, R 2 is (methylamino)methyl, and R 1 is fluoro .

[0401] In one embodiment, R 2 is aminomethyl, and R 1 is fluoro.

[0402] In one embodiment, R 2 is C1-C6 alkoxy, and R 1 is one or more NR 8 R 9 is C1-C6 alkyl optionally substituted with

[0403] In one embodiment, R 2 is methoxy and R 1 is (dimethylamino)methyl do.

[0404] In one embodiment, R 1 and R 2 are each bonded to a carbon atom of the aryl ring A.

[0405] In one embodiment, R 1 and R 2 are each bonded to a carbon atom of the heteroaryl ring A. can be.

[0406] In one embodiment, R 1 is attached to carbon and R 2 is the nitrogen of heteroaryl ring A is combined with

[0407] In one embodiment, R 2 is attached to carbon and R 1 is the nitrogen of heteroaryl ring A is combined with

[0408] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them Together with hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy Shi, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 aryl, and CONR 8 R 9 C5 optionally substituted with one or more substituents independently selected from Forms a carbocyclic ring.

[0409] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them Together with the above, they form a C5 aliphatic carbocyclic ring.

[0410] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them Together with hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy Shi, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 aryl, and CONR 8 R 9 C6 optionally substituted with one or more substituents independently selected from Forms a carbocyclic ring.

[0411] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them Together with the above, it forms a C6 aliphatic carbocyclic ring.

[0412] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them Together with the above, they form a C6 aromatic carbocyclic ring.

[0413] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 and forming a 5-membered heterocyclic ring optionally substituted with one or more substituents independently selected from Complete.

[0414] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. It forms a five-membered aliphatic heterocycle.

[0415] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. It forms a five-membered heteroaromatic ring.

[0416] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9and forming a 6-membered heterocyclic ring optionally substituted with one or more substituents independently selected from Complete.

[0417] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. It forms a six-membered aliphatic heterocycle.

[0418] In one embodiment, R 1 and R 2 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. It forms a six-membered heteroaromatic ring.

[0419] In one embodiment, R 1 and R 2 is different.

[0420] In one embodiment, R 1 and R 2 is different, R 2 contains a carbonyl group.

[0421] In one embodiment, R 1 and R 2 is different, R 2 1 or 2 (e.g., 1 ) containing a nitrogen atom.

[0422] In one embodiment, R 1 and R 2 is different, R 2 1 or 2 (e.g., 1 ) containing an oxygen atom.

[0423] In one embodiment, R 1 and R 2 is different, R 2contains a sulfur atom.

[0424] In one embodiment, R 2 and R 1 is different, R 2 contains a carbonyl group.

[0425] In one embodiment, R 2 and R 1 is different, R 2 1 or 2 (e.g., 1 ) containing a nitrogen atom.

[0426] In one embodiment, R 2 and R 1 is different, R 2 1 or 2 (e.g., 1 ) containing an oxygen atom.

[0427] In one embodiment, R 2 and R 1 is different, R 2 contains a sulfur atom.

[0428] In one embodiment, R 1 and R 2 is the same.

[0429] In one embodiment, R 1 is R 2 It is para or meta to.

[0430] In one embodiment, R 1 is R 2 It is para or ortho to

[0431] In one embodiment, R 1 is R 2 In some embodiments, Hey, R 1 is R 2 It is para.

[0432] In one embodiment, R 1is R 2 It is meta to that.

[0433] In one embodiment, R 1 is R 2 It is orthogonal to

[0434] Variables o and p In some embodiments, o=1 or 2.

[0435] In one embodiment, o=1.

[0436] In one embodiment, o=2.

[0437] In some embodiments, p=0, 1, 2, or 3.

[0438] In one embodiment, p=0.

[0439] In one embodiment, p=1.

[0440] In one embodiment, p=2.

[0441] In one embodiment, o=1 and p=0.

[0442] In some embodiments, o=2 and p=0.

[0443] In some embodiments, o=1 and p=1.

[0444] In some embodiments, o=1 and p=2.

[0445] In some embodiments, o=2 and p=1.

[0446] In some embodiments, o=2 and p=2.

[0447] In some embodiments, o=2 and p=3.

[0448] Ring B and substitution on ring B In some embodiments, B is a 5- to 10-membered monocyclic or bicyclic heteroaryl or C6~C 10 Monocyclic or bicyclic aryl, for example phenyl.

[0449] In one embodiment, B is a 5- to 6-membered monocyclic heteroaryl or a C6 monocyclic aryl. It is.

[0450] In certain embodiments, B is a 5- to 10-membered monocyclic or bicyclic heteroaryl.

[0451] In one embodiment, B is C 10 It is a monocyclic or bicyclic aryl.

[0452] In some embodiments, B is a 5-membered heteroaryl.

[0453] In some embodiments, B is a 7-10 membered monocyclic or bicyclic heteroaryl.

[0454] In some embodiments, B is one or two R 6 and 1, 2, or 3 R 7 is phenyl optionally substituted with

[0455] In some embodiments, B is one or two R 6 and 1, 2, or 3 R 7 is pyridyl optionally substituted with

[0456] In some embodiments, B is one or two R 6 and 1, 2, or 3 R 7 is indazolyl optionally substituted with

[0457] In some embodiments, B is one or two R 6 and one or two R 7 is pyrazolyl optionally substituted with

[0458] In some embodiments, B is phenyl, o is 1 or 2, and p is 0, 1, 2 or 3.

[0459] In some embodiments, B is phenyl, o is 1, and p is 0, 1, 2, or It is 3.

[0460] In some embodiments, B is phenyl, o is 2, and p is 0, 1, 2, or It is 3.

[0461] In certain embodiments, the present invention provides a method for the treatment of rhodium, ... In each case, the ring is one of the rings disclosed below in the [ka] The bond shown broken by connects B of formula AA to the NH(CO) group. .

[0462] In one embodiment, the substituted ring B [ka] teeth, [ka] is.

[0463] In one embodiment, the substituted ring B [ka] teeth, [ka] is.

[0464] In one embodiment, the substituted ring B is [ka] is.

[0465] In one embodiment, the substituted ring B is [ka] is.

[0466] In one embodiment, the substituted ring B is [ka] is.

[0467] In one embodiment, the substituted ring B is [ka] is.

[0468] In one embodiment, the substituted ring B is [ka] is.

[0469] In one embodiment, the substituted ring B is [ka] is.

[0470] In one embodiment, the substituted ring B is [ka] is.

[0471] In one embodiment, the substituted ring B is [ka] is.

[0472] In one embodiment, the substituted ring B is [ka] is.

[0473] In one embodiment, the substituted ring B is [ka] is.

[0474] In one embodiment, the substituted ring B is [ka] is.

[0475] In one embodiment, the substituted ring B is [ka] is.

[0476] In one embodiment, the substituted ring B is [ka] is.

[0477] In one embodiment, the substituted ring B is [ka] is.

[0478] In one embodiment, the substituted ring B is [ka] is.

[0479] In one embodiment, the substituted ring B is [ka] is.

[0480] In one embodiment, the substituted ring B is [ka] is.

[0481] In one embodiment, the substituted ring B is [ka] is.

[0482] In one embodiment, the substituted ring B is [ka] is.

[0483] In one embodiment, the substituted ring B is [ka] is.

[0484] In one embodiment, the substituted ring B is [ka] is.

[0485] In one embodiment, the substituted ring B is [ka] is.

[0486] In one embodiment, the substituted ring B is [ka] is.

[0487] In one embodiment, the substituted ring B is [ka] is.

[0488] In one embodiment, the substituted ring B is [ka] is.

[0489] In one embodiment, the substituted ring B is [ka] is.

[0490] In one embodiment, the substituted ring B is [ka] is.

[0491] In one embodiment, the substituted ring B is [ka] is.

[0492] In one embodiment, the substituted ring B is [ka] is.

[0493] In one embodiment, the substituted ring B is [ka] is.

[0494] In one embodiment, the substituted ring B is [ka] is.

[0495] In one embodiment, the substituted ring B is [ka] is.

[0496] In one embodiment, the substituted ring B is [ka] is.

[0497] In one embodiment, the substituted ring B is [ka] is.

[0498] In one embodiment, the substituted ring B is [ka] is.

[0499] In one embodiment, the substituted ring B is [ka] is.

[0500] In one embodiment, the substituted ring B is [ka] is.

[0501] In one embodiment, the substituted ring B is [ka] is.

[0502] In one embodiment, the substituted ring B is [ka] is.

[0503] In one embodiment, the substituted ring B is [ka] is.

[0504] In one embodiment, the substituted ring B is [ka] is.

[0505] In one embodiment, the substituted ring B is [ka] is.

[0506] In one embodiment, the substituted ring B is [ka] is.

[0507] In one embodiment, the substituted ring B is [ka] is.

[0508] In one embodiment, the substituted ring B is [ka] is.

[0509] In one embodiment, the substituted ring B is [ka] is.

[0510] In one embodiment, the substituted ring B is [ka] is.

[0511] In one embodiment, the substituted ring B is [ka] is.

[0512] base R 6 and R 7 In one embodiment, R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, S(O2) C1-C6 alkyl, C3-C 10 Cycloalkyl and 3 C-C alkenyl; where R 6 and R 7 are hydroxy, halo, CN, oxo, and C1-C6 alkoxy groups, respectively. Kyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C ONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 membered Heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO(5 3- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCOC 1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl cycloalkyl), NHCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl , C6~C 10 aryloxy, and S(O2)C1-C6 alkyl; wherein R 6 or R 7 is replaced by C1 -C6 alkyl or C1-C6 alkoxy is one or more hydroxyl, C6-C 10 a Reel or NR 8 R 9 or R 6 or R 7 is a 5- to 7-membered carbocyclic ring or a complex containing one or two heteroatoms independently selected from oxygen, sulfur and nitrogen optionally fused to a ring; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from is optionally substituted independently with one or more substituents selected from the following:

[0513] In one embodiment, R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, S(O2) C1-C6 alkyl, C3-C 10 Cycloalkyl and 3 C-C alkenyl; where R 6 and R 7 are hydroxy, halo, CN, oxo, and C1-C6 alkoxy groups, respectively. Kyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C ONR 8 R 9, 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 membered Heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO(5 3- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCOC 1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl cycloalkyl), NHCO(3- to 7-membered heterocycloalkyl), NHCOC2-C6 alkynyl , C6~C 10 aryloxy, and S(O2)C1-C6 alkyl; wherein R 6 or R 7 is replaced by C1 -C6 alkyl or C1-C6 alkoxy is one or more hydroxyl, C6-C 10 a Reel or NR 8 R 9 or R 6 or R 7 is a 5- to 7-membered carbocyclic ring or a complex containing one or two heteroatoms independently selected from oxygen, sulfur and nitrogen optionally fused to a ring; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of Together, at least one C4-C6 aliphatic carbocyclic ring or O, N, and S independently At least one 5- to 6-membered heterocycle containing one or two heteroatoms selected from independently formed, wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, hydroxymethyl, halo, Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 mosquito is optionally independently substituted with one or more substituents independently selected from:

[0514] In one embodiment, R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, SC1~C6 alkyl, S(O2)C1~C6 alkyl, C3~C7 selected from cycloalkyl and 3- to 7-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from is optionally substituted independently with one or more substituents selected from the following:

[0515] In one embodiment, R 6 and R 7 are each independently C1-C6 haloalkyl, C1-C6 alkoxy , C1-C6 haloalkoxy, halo, CN, NO2, COC1-C6 alkyl, CO2C 1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OC OC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3- to 7-membered Heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, NH2 , NHC1-C6 alkyl, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5, S C1-C6 alkyl, S(O2)C1-C6 alkyl, C3-C7 cycloalkyl and 3 selected from 5-7 membered heterocycloalkyl; Here, C3 to C7 cycloalkyl, C1 to C6 haloalkyl, and 3- to 7-membered heteroalkyl are Cycloalkyl is hydroxy, halo, CN, oxo, C1-C6 alkyl, C1-C6 Alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, CONR 8 R 9 , 3 1- to 7-membered heterocycloalkyl, C6-C 10 aryl, 5- to 10-membered heteroaryl, OCOC1~C6 alkyl, OCOC6~C 10 Aryl, OCO (5-10 membered heterocyclic Aryl), OCO(3- to 7-membered heterocycloalkyl), NHCOC1-C6 alkyl , NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkynyl, respectively optionally substituted with one or more independently selected substituents; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R9 Independence from is optionally substituted independently with one or more substituents selected from the following:

[0516] In one embodiment, R 6 and R 7 are each independently C1-C6 alkyl, halo, CN, NO2, CO C1-C6 alkyl, CO2C1-C6 alkyl, OCOC1-C6 alkyl, OCOC 6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3- to 7-membered heteroaryl), (cycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, NH2, N HC1-C6 alkyl, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5, SC1 ~C6 alkyl, S(O2)C1-C6 alkyl, C3-C7 cycloalkyl and 3-membered ~ 7-membered heterocycloalkyl; Here, C1 to C6 alkyl, C3 to C7 cycloalkyl and 3- to 7-membered heterocyclo Alkyl is hydroxy, halo, CN, oxo, C1-C6 alkyl, C1-C6 alkoxy. Kishi, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, CONR 8 R 9 , 3 to 7 members C-C 10 Aryl, 5- to 10-membered heteroaryl, OCO C1-C6 alkyl, OCOC6-C 10 Aryl, OCO (5- to 10-membered heteroaryl OCO(3- to 7-membered heterocycloalkyl), NHCOC1-C6 alkyl, NH COC6~C 10 Aryl, NHCO(5-membered to 10-membered heteroaryl), NHCO(3-membered 1-7-membered heterocycloalkyl), and NHCOC2-C6 alkynyl, optionally substituted with one or more substituents selected from wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl ; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from is optionally substituted independently with one or more substituents selected from the following:

[0517] In one embodiment, R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, SC1~C6 alkyl, S(O2)C1~C6 alkyl, C3~C7 selected from cycloalkyl and 3- to 7-membered heterocycloalkyl; where C1-C6 alkyl, C1-C6 haloalkyl, C3-C7 cycloalkyl, and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1 to C6 Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl ,CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-1 0-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO(3- to 7-membered heterocycloalkyl), NHC OC1~C6 alkyl, NHCOC6~C 10 Aryl, NHCO (5-10 membered hetero aryl), NHCO(3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: alkynyl; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) is unsubstituted; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from is optionally substituted independently with one or more substituents selected from the following:

[0518] In one embodiment, R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, SC1~C6 alkyl, S(O2)C1~C6 alkyl, C3~C7 selected from cycloalkyl and 3- to 7-membered heterocycloalkyl; Here, C1 to C6 alkyl, C3 to C7 cycloalkyl and 3- to 7-membered heterocyclo Each alkyl is unsubstituted; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C8 carbocyclic ring or independently selected from O, N, and S At least one 5- to 8-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from is optionally substituted independently with one or more substituents selected from the following:

[0519] In one embodiment, R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 halo Alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, C6-C1 0aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy Oxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, CO2C1- C6 alkyl, CO2C3~C6 cycloalkyl, OCOC1~C6 alkyl, OCOC 6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3- to 7-membered heteroaryl), (cycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 , SF5, S(O2)C1-C6 alkyl, C3-C7 cycloalkyl and 4- to 6-membered alkyl C1-C6 alkyl is selected from 1 to 2 C1 Optionally substituted with ~C6 alkoxy; or R 6 and R 7 together with the atoms connecting them form a C4 to C7 carbocyclic ring or O at least one heteroatom containing one or two heteroatoms independently selected from N, and S; and independently form two 5- to 7-membered heterocyclic rings, wherein the carbocyclic or heterocyclic ring is hydroxy, halo, or the like. Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , C OOC1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 Selected independently from and optionally substituted independently with one or more substituents as defined above.

[0520] In one embodiment, R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 alkoxy, halo CN, NO2, COC1-C6 alkyl, CO2C1-C6 alkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 and 3- to 7-membered heterocyclo alkyl, Here, C1-C6 alkyl and 3- to 7-membered heterocycloalkyl are hydroxy or optionally substituted with one or more substituents each independently selected from oxo; or R on the adjacent atom 6 and R 7 At least one pair of together independently form at least one C4-C8 carbocyclic ring, where the carbocyclic ring is , optionally substituted independently with one or more hydroxy or oxo.

[0521] In one embodiment, R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 alkoxy, halo CN, NO2, COC1-C6 alkyl, CO2C1-C6 alkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 and 3- to 7-membered heterocyclo alkyl, Here, C1-C6 alkyl and 3- to 7-membered heterocycloalkyl are hydroxy or optionally substituted with one or more substituents each independently selected from oxo; or R on the adjacent atom 6 and R 7 At least one pair of together independently form at least one C4-C6 aliphatic carbocyclic ring, The heterocycle is optionally substituted independently with one or more hydroxy or oxo.

[0522] In one embodiment, R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 alkoxy, halo CN, NO2, COC1-C6 alkyl, CO2C1-C6 alkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 and 3- to 7-membered heterocyclo alkyl, Here, C1-C6 alkyl and 3- to 7-membered heterocycloalkyl are hydroxy or optionally substituted with one or more substituents each independently selected from oxo; or R on the adjacent atom 6 and R7 At least one pair of together containing 1 or 2 heteroatoms independently selected from O, N, and S independently form at least one 5- to 8-membered heterocyclic ring, wherein the heterocyclic ring is one or more is optionally independently substituted with hydroxy or oxo.

[0523] In one embodiment, R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 alkoxy, halo CN, NO2, COC1-C6 alkyl, CO2C1-C6 alkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 and 3- to 7-membered heterocyclo alkyl, Here, C1-C6 alkyl and 3- to 7-membered heterocycloalkyl are hydroxy or optionally substituted with one or more substituents each independently selected from oxo; or R on the adjacent atom 6 and R 7 At least one pair of together independently form at least one C4-C8 carbocyclic ring, where the carbocyclic ring is , optionally substituted independently with one or more hydroxy or oxo.

[0524] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of independently form at least one C4-C6 aliphatic carbocyclic ring, wherein is optionally substituted independently with one or more hydroxy or oxo.

[0525] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of independently form at least one C4 aliphatic carbocyclic ring, wherein the carbocyclic ring is Optionally, independently substituted with one or more hydroxy or oxo.

[0526] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of independently form at least one C5 aliphatic carbocyclic ring, wherein the carbocyclic ring is Optionally, independently substituted with one or more hydroxy or oxo.

[0527] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of independently form at least one C6 aliphatic carbocyclic ring, wherein the carbocyclic ring is Optionally, independently substituted with one or more hydroxy or oxo.

[0528] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of and at least one heteroatom independently selected from O, N, and S. and independently form one more 5- to 6-membered heterocyclic ring, wherein the heterocyclic ring is or oxo.

[0529] In one embodiment, R on adjacent atoms 6 and R7 At least one pair of and at least one heteroatom independently selected from O, N, and S. and independently form one or more 5-membered heterocyclic rings, wherein the heterocyclic rings contain one or more hydroxy or oxy groups. is optionally independently substituted with xo.

[0530] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of and at least one heteroatom independently selected from O, N, and S. and independently form one more 6-membered heterocyclic ring, wherein the heterocyclic ring contains one or more hydroxy or oxy groups. is optionally independently substituted with xo.

[0531] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of independently form at least one C4 aliphatic carbocyclic ring, wherein the carbocyclic ring is Optionally substituted independently with one or more C1-C6 alkyls.

[0532] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of independently form at least one C5 aliphatic carbocyclic ring, wherein the carbocyclic ring is Optionally substituted independently with one or more C1-C6 alkyls.

[0533] In one embodiment, R on adjacent atoms 6 and R 7At least one pair of independently form at least one C6 aliphatic carbocyclic ring, wherein the carbocyclic ring is Optionally substituted independently with one or more C1-C6 alkyls.

[0534] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of and at least one heteroatom independently selected from O, N, and S. and independently form one more 5- to 6-membered heterocyclic ring, wherein the heterocyclic ring is one or more C1-C6 is optionally substituted independently with alkyl.

[0535] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of and at least one heteroatom independently selected from O, N, and S. and independently form one more 5-membered heterocycle, wherein the heterocycle is one or more C1-C6 alkyl groups. and optionally independently substituted with aryl.

[0536] In one embodiment, R on adjacent atoms 6 and R 7 At least one pair of and at least one heteroatom independently selected from O, N, and S. and independently form another 6-membered heterocycle, wherein the heterocycle is one or more C1-C6 alkyl groups. and optionally independently substituted with aryl.

[0537] In one embodiment, o=1; p=0; R6 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1 ~C6 haloalkoxy, halo, CN, NO2, COC1~C6 alkyl, CO2C1~C 6 alkyl, CO2C3-C8 cycloalkyl, OCOC1-C6 alkyl, OCOC6 ~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3- to 7-membered heteroaryl) Cycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, NH2, NH C1-C6 alkyl, N(C1-C6 alkyl)2, CONR 8 R 9 , SF5, SC1~ C6 alkyl, S(O2)C1-C6 alkyl, C3-C7 cycloalkyl and 3-membered to 7-membered membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (3- to 7-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl do.

[0538] In one embodiment, o=1; p=1; R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 alkoxy, halo CN, NO2, COC1-C6 alkyl, CO2C1-C6 alkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 and 3- to 7-membered heterocyclo alkyl, Here, C1-C6 alkyl and 3- to 7-membered heterocycloalkyl are hydroxy or optionally substituted with one or more substituents each independently selected from oxo; or R on the adjacent atom 6 and R 7 At least one pair of together independently form at least one C4-C8 carbocyclic ring, where the carbocyclic ring is , optionally substituted independently with one or more hydroxy or oxo.

[0539] In some embodiments, o=1 or 2; p=1, 2, or 3; R 6 and R 7are each independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, NO2, COC1-C 6 alkyl, CO2C1-C6 alkyl, CO2C3-C8 cycloalkyl, OCOC1 ~C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl) , OCO(3- to 7-membered heterocycloalkyl), C6-C 10 Aryl, 5-10 membered aryl Tetraaryl, NH2, NHC1-C6 alkyl, N(C1-C6 alkyl)2, CON R 8 R 9 , SF5, SC1~C6 alkyl, S(O2)C1~C6 alkyl, C3~C7 selected from cycloalkyl and 3- to 7-membered heterocycloalkyl; where C1-C6 alkyl, C1-C6 haloalkyl, C3-C7 cycloalkyl, and 3- to 7-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1 to C6 Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl ,CONR 8 R 9 , 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-1 0-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO(3- to 7-membered heterocycloalkyl), NHC OC1~C6 alkyl, NHCOC6~C 10 Aryl, NHCO (5-10 membered hetero aryl), NHCO(3- to 7-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: alkynyl; wherein 3- to 7-membered heterocycloalkyl, C6-C 10 Aryl, 5-10-membered heptane Roaryl, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl) and NHCO(3- to 7-membered heterocycloalkyl) are halo, C1-C6 alkyl, and Optionally substituted with one or more substituents independently selected from OC1-C6 alkyl do.

[0540] In one embodiment, o=2; p=1; Each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 halides alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, C6-C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy Oxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, CO2C1- C6 alkyl, CO2C3~C6 cycloalkyl, OCOC1~C6 alkyl, OCOC 6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3- to 7-membered heteroaryl), (cycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 , SF5, S(O2)C1-C6 alkyl, C3-C7 cycloalkyl and 4- to 6-membered alkyl C1-C6 alkyl is selected from 1 to 2 C1 Optionally substituted with ~C6 alkoxy; or R 6 and R 7 together with the atoms connecting them form a C4 to C7 carbocyclic ring or O at least one heteroatom containing one or two heteroatoms independently selected from N, and S; and independently form two 5- to 7-membered heterocyclic rings, wherein the carbocyclic or heterocyclic ring is hydroxy, halo, or the like. Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , C OOC1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 Selected independently from and optionally substituted independently with one or more substituents as defined above.

[0541] In some embodiments, o=2; p=2 or 3; Each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 halides alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, C6-C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; Here, each R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1- C6 alkoxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, C O2C1-C6 alkyl, CO2C3-C6 cycloalkyl, OCOC1-C6 alkyl , OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered ~7-membered heterocycloalkyl), C6-C 10 aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 , SF5, S(O2) C1-C6 alkyl, C3-C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl, wherein C1-C6 alkyl is selected from 1 to optionally substituted with two C1-C6 alkoxy; or R on the adjacent atom 6 and R 7 At least one pair of Together they form at least one C4-C7 (e.g., C4-C6) carbocyclic ring (e.g., an alicyclic ring) aliphatic carbocyclic rings) or containing 1 or 2 heteroatoms independently selected from O, N, and S independently form at least one 5- to 7-membered (e.g., 5- to 6-membered) heterocyclic ring having wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, C1 to C6 Alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COO C1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 are selected independently from and optionally substituted independently with one or more substituents selected from the group consisting of:

[0542] In some embodiments, o=1 or 2; p=1, 2, or 3; R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 alkoxy, halo CN, NO2, COC1-C6 alkyl, CO2C1-C6 alkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 and 3- to 7-membered heterocyclo alkyl, Here, C1-C6 alkyl and 3- to 7-membered heterocycloalkyl are hydroxy or optionally substituted with one or more substituents each independently selected from oxo; or R on the adjacent atom 6 and R 7 At least one pair of together independently form at least one C4-C8 carbocyclic ring, where the carbocyclic ring is , optionally substituted independently with one or more hydroxy or oxo.

[0543] In some embodiments, o=1 or 2; p=1, 2, or 3; R 6 and R 7 are each independently C1-C6 alkyl, C1-C6 alkoxy, halo CN, NO2, COC1-C6 alkyl, CO2C1-C6 alkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 and 3- to 7-membered heterocyclo alkyl, Here, C1-C6 alkyl and 3- to 7-membered heterocycloalkyl are hydroxy or and optionally substituted with one or more substituents each independently selected from oxo.

[0544] In some embodiments, o=1 or 2; p=1, 2, or 3; One R 6 and one R 7 are on adjacent atoms, together with the atoms that connect them. C4-C8 carbocyclic ring or one or two heterocyclic rings independently selected from O, N, and S. forming a 5- to 8-membered heterocyclic ring containing a carbon atom, wherein the carbocyclic or heterocyclic ring is , halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independent from Optionally substituted independently with one or more selected substituents.

[0545] In some embodiments, o=1 or 2; p=1, 2, or 3; One R 6 and one R 7 are on adjacent atoms, together with the atoms that connect them. C6 carbocyclic ring or 1 or 2 heteroatoms independently selected from O, N, and S wherein the carbocyclic or heterocyclic ring is a 5- to 6-membered heterocyclic ring containing hydroxy, halo, , oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , CO OC1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 selected independently from and optionally substituted independently with one or more substituents selected from the group consisting of aryl, ...

[0546] In some embodiments, o=1 or 2; p=1, 2, or 3; One R 6 and one R 7are on adjacent atoms, together with the atoms that connect them. C4-C8 carbocyclic ring or one or two heterocyclic rings independently selected from O, N, and S. Forms a 5- to 8-membered heterocyclic ring containing a carbon atom, wherein the carbocyclic or heterocyclic ring is unsubstituted. .

[0547] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, forms a C4-C8 carbocyclic ring or is a 5- to 8-membered alkyl group containing one or two heteroatoms independently selected from O, N, and S; and independently form a membered heterocycle, wherein each carbocycle or heterocycle is selected from the group consisting of hydroxy, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~ C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 one independently selected from Optionally, independently substituted with the above substituents.

[0548] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair together with the atoms connecting them forms a C6 carbocyclic ring or O, 5- to 6-membered heteroatoms containing 1 or 2 heteroatoms independently selected from N and S independently form a ring, wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1- C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6Al Kill, C6~C 10 Aryl, and CONR 8 R 9 one or more positions independently selected from Optionally independently substituted with substituents.

[0549] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, independently forms a C5 carbocyclic ring. wherein the carbocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkyl, C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 a Reel and CONR 8 R 9 and optionally with one or more substituents independently selected from It is replaced by

[0550] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, independently forms a C4 carbocyclic ring. wherein the carbocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkyl, C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 a Reel and CONR 8 R 9 and optionally with one or more substituents independently selected from It is replaced by

[0551] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 One pair of these, together with the atoms connecting them, form a C4 carbocyclic ring independently. Formed by standing, one R 6 and one R 7 The other pair of atoms, together with the atoms that connect them, independently form a C5 carbocyclic ring, wherein each of the C4 and C5 carbocyclic rings is a hydroxyl group. oxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =N R 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 From Germany Optionally substituted with one or more substituents independently selected from the group consisting of:

[0552] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 One pair of these, together with the atoms connecting them, form a C5 carbocyclic ring independently. Formed by standing, one R 6 and one R 7 The other pair of atoms, together with the atoms that connect them, and 5, containing 1 or 2 heteroatoms independently selected from O, N, and S. 1- to 8-membered heterocycles (e.g., 5-membered heterocycles, e.g., 5-membered heterocycles containing one heteroatom) ), wherein each of the carbocyclic and heterocyclic rings is independently selected from the group consisting of hydroxy, halo, oxy, and the like. SO, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1 ~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 1 independently selected from Optionally substituted independently with one or more substituents.

[0553] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, forms a C4-C8 carbocyclic ring or is a 5- to 8-membered alkyl group containing one or two heteroatoms independently selected from O, N, and S; The carbocycle or heterocycle independently forms a membered heterocycle, wherein the carbocycle or heterocycle is unsubstituted.

[0554] Particular embodiments where o=1; p=0: In one embodiment, R 6 is C1-C6 alkyl.

[0555] In one embodiment, R 6 is isopropyl.

[0556] In one embodiment, R6 is ethyl.

[0557] In one embodiment, R 6 is methyl.

[0558] In one embodiment, R 6 is C1-C6 alkyl substituted with one or more halo do.

[0559] In one embodiment, R 6 is trifluoromethyl.

[0560] In one embodiment, R 6 is trifluoromethoxy.

[0561] In one embodiment, R 6 is a C3-C7 cycloalkyl.

[0562] In one embodiment, R 6 is cyclopropyl.

[0563] In one embodiment, R 6 is a halo.

[0564] In one embodiment, R 6 is chloro.

[0565] In one embodiment, R 6 is fluoro.

[0566] In one embodiment, R 6 is cyano.

[0567] In one embodiment, R 6 is attached to a carbon of the aryl ring B.

[0568] In one embodiment, R 6 is attached to a carbon of the heteroaryl ring B.

[0569] In one embodiment, R 6 is attached to the nitrogen of the heteroaryl ring B.

[0570] In particular embodiments where o=1 or 2; and p=1, 2, or 3: In some embodiments, at least one R 6 is a C1-C6 alkyl, and at least Another R 7 is a C1-C6 alkyl optionally substituted with one or more halo.

[0571] In some embodiments, at least one R 6 is a C1-C6 alkyl, and at least Another R 7 is C1-C6 alkyl.

[0572] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is methyl.

[0573] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is isopropyl.

[0574] In one embodiment, o=1; p=1; and R 6 is isopropyl; R 7 is isopropyl.

[0575] In some embodiments, at least one R 6 is a C1-C6 alkyl, and at least Another R 7 is a C1-C6 alkyl substituted with one or more halo.

[0576] In some embodiments, at least one R 6is isopropyl and at least one R 7 is trifluoromethyl.

[0577] In some embodiments, at least one R 6 is a C1-C6 alkyl, and at least Another R 7 is a C3-C7 cycloalkyl.

[0578] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is cyclopropyl.

[0579] In one embodiment, o=1; p=1; and R 6 is isopropyl; R 7 is cyclopropyl.

[0580] In some embodiments, at least one R 6 is a C1-C6 alkyl, and at least Another R 7 is a halo.

[0581] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is a halo.

[0582] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is chloro.

[0583] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is fluoro.

[0584] In one embodiment, o=1; p=1; and R 6 is isopropyl; R 7 is chloro.

[0585] In one embodiment, o=2; p=1; and at least one R 6 Isop R 7 is chloro.

[0586] In one embodiment, o=1; p=1; and R 6 is isopropyl; R 7 is fluoro.

[0587] In one embodiment, o=2; p=1; and at least one R 6 Isop R 7 is fluoro.

[0588] In one embodiment, o=2; p=2; and at least one R 6 Isop at least one R 7 is fluoro.

[0589] In one embodiment, o=2; p=2; and at least one R 6 Isop R 7 is fluoro; the other R 7 is cyano.

[0590] In one embodiment, o=2; p=3; and at least one R 6 Isop R 7 is fluoro; one R 7 is chloro.

[0591] In one embodiment, o=2; p=1; and at least one R 6 is ethyl and;R 7 is fluoro.

[0592] In one embodiment, o=2; p=1; and one R 6 is isopropyl the other R 6 is trifluoromethyl; R 7 is chloro.

[0593] In some embodiments, at least one R 6 is a C1-C6 alkyl, and at least Another R 7 is cyano.

[0594] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is cyano.

[0595] In one embodiment, o=1; p=1; and R 6 is isopropyl; R 7 is cyano.

[0596] In one embodiment, o=2; p=1; and at least one R 6 Isop R 7 is cyano.

[0597] In some embodiments, at least one R 6 is a C3-C7 cycloalkyl, At least one R 7 is a C3-C7 cycloalkyl.

[0598] In some embodiments, at least one R 6 is cyclopropyl, and at least one R 7 is cyclopropyl.

[0599] In some embodiments, at least one R 6 is a C3-C7 cycloalkyl, At least one R 7 is a halo.

[0600] In some embodiments, at least one R 6 is cyclopropyl, and at least one R 7 is a halo.

[0601] In some embodiments, at least one R 6 is cyclopropyl, and at least one R 7 is chloro.

[0602] In some embodiments, at least one R 6 is cyclopropyl, and at least one R 7 is fluoro.

[0603] In one embodiment, o=1; p=1; and R 6 is cyclopropyl; R 7 is chloro.

[0604] In one embodiment, o=1; p=1; and R 6 is cyclopropyl; R 7 is fluoro.

[0605] In some embodiments, at least one R 6 is a C1-C6 alkyl, and at least Another R 7 is C1-C6 alkoxy optionally substituted with one or more halo .

[0606] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is C1-C6 alkoxy.

[0607] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is methoxy.

[0608] In one embodiment, o=1; p=1; and R 6 is isopropyl, and R 7 is methoxy.

[0609] In one embodiment, o=2; p=1; and at least one R 6 Isop R 7 is methoxy.

[0610] In some embodiments, at least one R 6 is a C1-C6 alkyl, and at least Another R 7 is C1-C6 alkoxy substituted with one or more halo.

[0611] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is trifluoromethoxy.

[0612] In some embodiments, at least one R 6 is isopropyl and at least one R 7 is difluoromethoxy.

[0613] In some embodiments, at least one R 6 is a halo and contains at least one R7 teeth , C1-C6 haloalkyl optionally substituted with hydroxy.

[0614] In one embodiment, o=1; p=1; and R 6 is chloro and R 7 Hato It is trifluoromethyl.

[0615] In some embodiments, at least one R 6 is a halo and contains at least one R 7 teeth C1-C6 haloalkoxy.

[0616] In some embodiments, at least one R 6 is chloro and at least one R 7 is trifluoromethoxy.

[0617] In one embodiment, o=1; p=1; and R 6 is chloro and R 7 Hato It is trifluoromethoxy.

[0618] In some embodiments, at least one R 6 is C1-C6 alkoxy; Together with R 7 is a halo.

[0619] In one embodiment, o=1; p=2; and R 6 is C1-C6 alkoxy Yes; at least one R 7 is chloro.

[0620] In some embodiments, at least one R 7 is a C1-C6 alkyl, and at least Another R 6 is a C1-C6 alkyl optionally substituted with one or more halo.

[0621] In some embodiments, at least one R 7 is isopropyl and at least one R 6 is methyl.

[0622] In some embodiments, at least one R 7 is a C1-C6 alkyl, and at least Another R 6 is a C1-C6 alkyl substituted with one or more halo.

[0623] In some embodiments, at least one R 7 is isopropyl and at least one R 6 is trifluoromethyl.

[0624] In some embodiments, at least one R 7 is a C1-C6 alkyl, and at least Another R 6 is a C3-C7 cycloalkyl.

[0625] In some embodiments, at least one R 7 is isopropyl and at least one R 6 is cyclopropyl.

[0626] In one embodiment, o=1; p=1; and R 7 is isopropyl; R 6 is cyclopropyl.

[0627] In some embodiments, at least one R 7 is a C1-C6 alkyl, and at least Another R 6 is a halo.

[0628] In some embodiments, at least one R 7is isopropyl and at least one R 6 is a halo.

[0629] In some embodiments, at least one R 7 is isopropyl and at least one R 6 is chloro.

[0630] In some embodiments, at least one R 7 is isopropyl and at least one R 6 is fluoro.

[0631] In one embodiment, o=1; p=1; and R 7 is isopropyl; R 6 is chloro.

[0632] In one embodiment, o=2; p=1; and R 7 is isopropyl; At least one R 6 is chloro.

[0633] In one embodiment, o=1; p=1; and R 7 is isopropyl; R 6 is fluoro.

[0634] In one embodiment, o=2; p=1; and R 7 is isopropyl; At least one R 6 is fluoro.

[0635] In one embodiment, o=2; p=2; and R 7 is isopropyl; At least one R 6 is fluoro.

[0636] In one embodiment, o=2; p=2; and at least one R 7 Isop R 6 is fluoro; the other R 6 is cyano.

[0637] In one embodiment, o=2; p=1; and R 7 is ethyl; at least Another R 6 is fluoro.

[0638] In one embodiment, o=1; p=2; and one R 7 is isopropyl the other R 7 is trifluoromethyl; R 6 is chloro.

[0639] In some embodiments, at least one R 7 is a C1-C6 alkyl, and at least Another R 6 is cyano.

[0640] In some embodiments, at least one R 7 is isopropyl and at least one R 6 is cyano.

[0641] In one embodiment, o=1; p=1; and R 7 is isopropyl; R 6 is cyano.

[0642] In one embodiment, o=2; p=1; and R 7 is isopropyl; At least one R 6 is cyano.

[0643] In some embodiments, at least one R 7is a C3-C7 cycloalkyl, At least one R 6 is a C3-C7 cycloalkyl.

[0644] In some embodiments, at least one R 7 is cyclopropyl, and at least one R 6 is cyclopropyl.

[0645] In some embodiments, at least one R 7 is a C3-C7 cycloalkyl, At least one R 6 is a halo.

[0646] In some embodiments, at least one R 7 is cyclopropyl, and at least one R 6 is a halo.

[0647] In some embodiments, at least one R 7 is cyclopropyl, and at least one R 6 is chloro.

[0648] In some embodiments, at least one R 7 is cyclopropyl, and at least one R 6 is fluoro.

[0649] In one embodiment, o=1; p=1; and R 7 is cyclopropyl; R 6 is chloro.

[0650] In one embodiment, o=1; p=1; and R 7 is cyclopropyl; R 6 is fluoro.

[0651] In some embodiments, at least one R 7 is a C1-C6 alkyl, and at least Another R 6 is C1-C6 alkoxy optionally substituted with one or more halo .

[0652] In some embodiments, at least one R 7 is isopropyl and at least one R 6 is C1-C6 alkoxy.

[0653] In some embodiments, at least one R 7 is isopropyl and at least one R 6 is methoxy.

[0654] In one embodiment, o=1; p=1; and R 7 is isopropyl, and R 6 is methoxy.

[0655] In one embodiment, o=2; p=1; and R 7 is isopropyl, and At least one R 6 is methoxy.

[0656] In some embodiments, at least one R 7 is a C1-C6 alkyl, and at least Another R 6 is C1-C6 alkoxy substituted with one or more halo.

[0657] In some embodiments, at least one R 7 is isopropyl and at least one R 6 is trifluoromethoxy.

[0658] In some embodiments, at least one R 7is a halo and contains at least one R 6 teeth , C1-C6 haloalkyl optionally substituted with one or more hydroxy.

[0659] In one embodiment, o=1; p=1; and R 7 is chloro and R 6 Hato It is trifluoromethyl.

[0660] In some embodiments, at least one R 7 is a halo and contains at least one R 6 teeth C1-C6 haloalkoxy.

[0661] In some embodiments, at least one R 7 is chloro and at least one R 6 is trifluoromethoxy.

[0662] In one embodiment, o=1; p=1; and R 7 is chloro and R 6 Hato It is trifluoromethoxy.

[0663] In some embodiments, at least one R 7 is C1-C6 alkoxy; Together with R 6 is a halo.

[0664] In one embodiment, o=1; p=2; and at least one R 7 is C1~ C6 alkoxy; R 6 is chloro.

[0665] In one embodiment, R 6 and R 7 are each bonded to a carbon atom of the aryl ring B.

[0666] In one embodiment, R 6 and R 7 are each bonded to a carbon atom of the heteroaryl ring B. can be.

[0667] In one embodiment, R 6 is attached to carbon and R 7 is the nitrogen of heteroaryl ring B is combined with

[0668] In one embodiment, R 7 is attached to carbon and R 6 is the nitrogen of heteroaryl ring B is combined with

[0669] In one embodiment, one R 6 and one R 7 are on adjacent atoms, and Together with the connecting atom, it can be hydroxy, halo, oxo, C1-C6 alkyl, C1- C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 a Reel and CONR 8 R 9 and optionally substituted with one or more substituents independently selected from This forms a C5 carbocyclic ring which is substituted.

[0670] In one embodiment, R 6 and R 7 is on adjacent atoms and connects them Together with the above, they form a C5 aliphatic carbocyclic ring.

[0671] In one embodiment, R 6 and R 7 is on adjacent atoms and connects them Together with hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy Shi, NR8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 aryl, and CONR 8 R 9 C6 optionally substituted with one or more substituents independently selected from Forms a carbocyclic ring.

[0672] In one embodiment, R 6 and R 7 is on adjacent atoms and connects them Together with the above, it forms a C6 aliphatic carbocyclic ring.

[0673] In one embodiment, R 6 and R 7 is on adjacent atoms and connects them Together with the above, they form a C6 aromatic carbocyclic ring.

[0674] In one embodiment, R 6 and R 7 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 and forming a 5-membered heterocyclic ring optionally substituted with one or more substituents independently selected from Complete.

[0675] In one embodiment, R 6 and R 7 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. It forms a five-membered aliphatic heterocycle.

[0676] In one embodiment, R 6 and R 7 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. It forms a five-membered heteroaromatic ring.

[0677] In one embodiment, R 6 and R 7 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 and forming a 6-membered heterocyclic ring optionally substituted with one or more substituents independently selected from Complete.

[0678] In one embodiment, R 6 and R 7 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. It forms a six-membered aliphatic heterocycle.

[0679] In one embodiment, R 6 and R 7 is on adjacent atoms and connects them and together contain one or two heteroatoms independently selected from O, N, and S. It forms a six-membered heteroaromatic ring.

[0680] In one embodiment, one R 6 and one R 7 are on adjacent atoms, and together with the atoms to which it is attached, a C4-C8 carbocyclic ring or a ring independently selected from O, N, and S forming a 5- to 8-membered heterocyclic ring containing 1 or 2 heteroatoms, wherein the ring has a B at the 2 and 3 positions relative to the bond connecting the B ring to the NH(CO) group. It is fused to a ring.

[0681] In one embodiment, o=1; p=2; One R 6 and one R 7 one pair of is on adjacent atoms; one R 6 and one R 7 The pair of carbon atoms, together with the atoms connecting them, may form a C4-C8 carbocyclic ring or an O, N and a 5- to 8-membered heterocycle containing 1 or 2 heteroatoms independently selected from S. Forming Here, the ring is B ring and NR 3 At positions 2 and 3 relative to the bond connecting to the (CO) group It is fused to the B ring.

[0682] In one embodiment, o=1; p=2; One R 6 and one R 7 one pair of is on adjacent atoms; one R 6 and one R 7 together with the atom connecting them, can be hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C 6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 one or more independently selected from Forms a C4-C8 carbocyclic ring optionally substituted independently with the above substituents.

[0683] In one embodiment, o=1; p=2; One R 6 and one R 7 one pair of is on adjacent atoms; one R 6 and one R 7 together with the atom connecting them, can be hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C 6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 one or more independently selected from Forms a C5 carbocyclic ring optionally substituted independently with the above substituents.

[0684] In one embodiment, o=1; p=2; One R 6 and one R 7 one pair of is on adjacent atoms; one R 6 and one R 7 said pair together with the atoms connecting them form a C5 aliphatic carbocyclic ring .

[0685] In one embodiment, o=2; p=2; One R 6 and one R 7 one pair of is on adjacent atoms; one R 6 and one R 7together with the atom connecting them, can be hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C 6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 one or more independently selected from Forms a C4-C8 carbocyclic ring optionally substituted independently with the above substituents.

[0686] In one embodiment, o=2; p=2; One R 6 and one R 7 one pair of is on adjacent atoms; one R 6 and one R 7 together with the atom connecting them, can be hydroxy, halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C 6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 one or more independently selected from Forms a C5 carbocyclic ring optionally substituted independently with the above substituents.

[0687] In one embodiment, o=1; p=2; One R 6 and one R 7 one pair of is on adjacent atoms; one R 6 and one R 7 said pair together with the atoms connecting them form a C5 aliphatic carbocyclic ring .

[0688] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms; 6 and one R 7 One pair of these, together with the atom that connects them, forms a hydroxyl, halo, Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , C OOC1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 Selected independently from forming a C4 carbocyclic ring optionally substituted independently with one or more substituents as defined above; R 6 and one R 7 The other pair together with the atom connecting them is a hydroxyl, Halo, oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 Selected independently from The carbon atom forms a C5 carbocyclic ring optionally substituted independently with one or more substituents selected from the group consisting of aryl, ...

[0689] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms; 6 and one R 7 One pair of carbon atoms, together with the atoms that connect them, form a C4 aliphatic carbon atom. Forms a ring and has one R 6 and one R 7 The other pair, together with the atom that connects them, This forms a C5 aliphatic carbocyclic ring.

[0690] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atom connecting them, can be a hydroxy, halo, Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COO C1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 are selected independently from and forming a C5 carbocyclic ring optionally substituted independently with one or more substituents selected from the group consisting of:

[0691] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, forms a C5 aliphatic carbocyclic ring. Form.

[0692] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atom connecting them, can be a hydroxy, halo, Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR10 , COO C1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 are selected independently from and forming a C6 carbocyclic ring optionally substituted independently with one or more substituents selected from the group consisting of:

[0693] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, forms a C6 aliphatic carbocyclic ring. Form.

[0694] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms that connect them, forms a C6 aromatic carbocyclic ring. Form.

[0695] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair of atoms, together with the atoms that connect them, is made up of O, N, and S. Contains 1 or 2 independently selected heteroatoms, and is selected from hydroxy, halo, oxo, C 1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 Alkyl, C6-C 10 Aryl, and CONR 8 R 9 one or more independently selected from Forms a 5-membered heterocyclic ring optionally substituted with a substituent of the formula:

[0696] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair of atoms, together with the atoms that connect them, is made up of O, N, and S. Forms a 5-membered aliphatic heterocycle containing 1 or 2 independently selected heteroatoms.

[0697] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair of atoms, together with the atoms that connect them, is made up of O, N, and S. Form a 5-membered heteroaromatic ring containing 1 or 2 independently selected heteroatoms.

[0698] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair of atoms, together with the atoms that connect them, is made up of O, N, and S. Contains 1 or 2 independently selected heteroatoms, and is selected from hydroxy, halo, oxo, C 1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR10 , COOC1~C6 Alkyl, C6-C 10 Aryl, and CONR 8 R 9 one or more independently selected from Forms a 6-membered heterocyclic ring optionally substituted with the substituents:

[0699] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair of atoms, together with the atoms that connect them, is made up of O, N, and S. Forms a 6-membered aliphatic heterocycle containing 1 or 2 independently selected heteroatoms.

[0700] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair of atoms, together with the atoms that connect them, is made up of O, N, and S. Form a 6-membered heteroaromatic ring containing 1 or 2 independently selected heteroatoms.

[0701] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms; 6 and one R 7 One pair of these, together with the atom that connects them, forms a hydroxyl, halo, Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10, C OOC1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 Selected independently from C optionally substituted independently with one or more substituents 4~8 Forms a carbocyclic ring; 1 R 6 and one R 7 The other pair, together with the atoms that connect them, are O, N, and S, containing 1 or 2 heteroatoms independently selected from hydroxy, halo, Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COO C1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 are selected independently from and forming a 5- to 8-membered heterocyclic ring optionally substituted with one or more substituents selected from the group consisting of aryl, aryl, aryls ...

[0702] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms; 6 and one R 7 One pair of carbon atoms, together with the atoms that connect them, form a C5 aliphatic carbon atom. Forms a ring and has one R 6 and one R 7 The other pair, together with the atom that connects them, and a five-membered alkyl group containing one or two heteroatoms independently selected from O, N, and S. Forms an aliphatic heterocycle.

[0703] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7Each pair of R is on adjacent atoms; 6 and one R 7 One pair of these, together with the atom that connects them, forms a hydroxyl, halo, Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , C OOC1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 Selected independently from forming a C5 carbocyclic ring optionally substituted independently with one or more substituents as defined above; R 6 and one R 7 The other pair, together with the atoms that connect them, are O, N, and S containing 1 or 2 heteroatoms independently selected from hydroxy, halo, oxy, SO, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1 ~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 1 independently selected from Forms a 6-membered heterocyclic ring optionally substituted with one or more substituents.

[0704] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms; 6 and one R 7 One pair of carbon atoms, together with the atoms that connect them, form a C5 aliphatic carbon atom. Forms a ring and has one R 6 and one R 7 The other pair, together with the atom that connects them, and a five-membered alkyl group containing one or two heteroatoms independently selected from O, N, and S. Forms an aliphatic heterocycle.

[0705] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, forms a C4-C8 carbocyclic ring or is a 5- to 8-membered alkyl group containing one or two heteroatoms independently selected from O, N, and S; independently form a heterocyclic ring, Here, one of the two rings is connected to the B ring by NR 3 2-position relative to the bond connecting to the (CO) group and fused to ring B at the 3-position, the other of the two rings being a bond connecting ring B to the NH(CO) group It is fused to the B ring at the 5 and 6 positions relative to

[0706] In some embodiments, o=2; p=2 or 3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, forms a C4-C8 carbocyclic ring or is a 5- to 8-membered alkyl group containing one or two heteroatoms independently selected from O, N, and S; independently form a heterocyclic ring, Here, one of the two rings is connected to the B ring by NR 3 2-position relative to the bond connecting to the (CO) group and fused to ring B at the 3-position, the other of the two rings being a bond connecting ring B to the NH(CO) group It is fused to the B ring at the 4th and 5th positions relative to

[0707] In one embodiment, o=2; p=2; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, forms a C5 aliphatic carbocyclic ring. Form.

[0708] In one embodiment, o=2; p=2; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 One pair of carbon atoms, together with the atoms that connect them, form a C4 aliphatic carbon atom. Forms a ring and has one R 6 and one R 7 The other pair, together with the atom that connects them, This forms a C5 aliphatic carbocyclic ring.

[0709] In one embodiment, o=2; p=2; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, forms a C4 aliphatic carbocyclic ring. Form.

[0710] In one embodiment, o=2; p=2; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 One pair of carbon atoms, together with the atoms that connect them, form a C5 aliphatic carbon atom. Forms a ring and has one R 6 and one R 7 The other pair, together with the atom that connects them, and a five-membered alkyl group containing one or two heteroatoms independently selected from O, N, and S. Forms a heterocyclic ring.

[0711] In one embodiment, o=2; p=3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, forms a C5 aliphatic carbocyclic ring. Forming; 1 R 7 is halo (e.g., Cl or F).

[0712] In one embodiment, o=2; p=3; One R 6 and one R 7 Each pair of R is on adjacent atoms, and 6 and one R 7 Each pair, together with the atoms connecting them, forms a C5 aliphatic carbocyclic ring. Forming; 1 R 7 is CN.

[0713] In one embodiment, one R 7 is pyrazolyl, and the B ring of formula AA is NH(CO) It is para to the bond connecting it to the group.

[0714] In one embodiment, one R 7 is 3-pyrazolyl, and the B ring of formula AA is NH(C O) group.

[0715] In one embodiment, one R 7 is 4-pyrazolyl, and the B ring of formula AA is NH(C O) group.

[0716] In one embodiment, one R 7 is 5-pyrazolyl, and the B ring of formula AA is NH(C O) group.

[0717] In one embodiment, one R 7 is thiazolyl, and the B ring of formula AA is NH(CO) It is para to the bond connecting it to the group.

[0718] In one embodiment, one R 7 is 4-thiazolyl, and the B ring of formula AA is NH(C O) group.

[0719] In one embodiment, one R 7 is 5-thiazolyl, and the B ring of formula AA is NH(C O) group.

[0720] In one embodiment, one R 7 is a furyl, and the B ring of formula AA is converted to an NH(CO) group. It is para to the connecting bond.

[0721] In one embodiment, one R 7 is 2-furyl, and the B ring of formula AA is NH(CO) It is para to the bond connecting it to the group.

[0722] In one embodiment, one R 7 is thiophenyl, and the B ring of formula AA is NH(CO ) group.

[0723] In one embodiment, one R 7 is 2-thiophenyl, and the B ring of formula AA is NH( It is para to the bond connecting it to the CO) group.

[0724] In one embodiment, one R 7 is phenyl, and the B ring of formula AA is an NH(CO) group. It is para to the bond that connects it to.

[0725] In one embodiment, one R 7 is a cycloalkenyl (e.g., cyclopentenyl, For example, 1-cyclopentenyl), and the B ring of formula AA is NR 3 (CO) group It is parallel to the combination.

[0726] In one embodiment, one R 7 is one or more hydroxyl, NR 8 R 9 (for example , dimethylamino), or C6-C 10 Aryl (e.g., phenyl, naphthyl, or is one or more C1-C6 alkyl ( For example, phenyl optionally substituted with methyl or propyl, e.g., 2-propyl). and is para to the bond connecting ring B of formula AA to the NH(CO) group.

[0727] In one embodiment, one R 7 is one or more hydroxyl, NR 8 R 9 (for example , dimethylamino), or C6-C 10 Aryl (e.g., phenyl, naphthyl, or is one or more C1-C6 alkoxy optionally substituted with methylenedioxyphenyl (e.g., methoxy), and the B ring of formula AA is substituted with NH( It is para to the bond connecting it to the CO) group.

[0728] In one embodiment, one R 7 is one or more C6-C 10 Aryloxy (e.g. and the B ring of formula AA is phenyl optionally substituted with NH(CO). ) group.

[0729] In one embodiment, one R 7 is a phenyl group optionally substituted with one or more CNs. is nyl and is para to the bond connecting the B ring of formula AA to the NH(CO) group.

[0730] In one embodiment, one R 7 is optionally substituted with one or more halo (e.g., F, Cl). phenyl optionally substituted with phenyl, and the bond connecting ring B of formula AA to the NH(CO) group It is para to the bond connecting the B ring of formula AA to the NH(CO) group.

[0731] In one embodiment, one R 7 is one or more COOC1-C6 alkyl (e.g. , CO2t-Bu), and the B ring of formula AA is phenyl optionally substituted with NH(C O) group.

[0732] In one embodiment, one R 7 is one or more S(O2)C1-C6 alkyl (e.g. For example, phenyl optionally substituted with S(O2)methyl), and the B ring of formula AA is N It is para to the bond connecting it to the H(CO) group.

[0733] In one embodiment, one R 7 is one or more 3- to 7-membered heterocycloalkyl( For example, phenyl optionally substituted with morpholinyl), and the B ring of formula AA is substituted with NH It is para to the bond connecting it to the (CO) group.

[0734] In one embodiment, one R 7 is one or more CONR 8 R 9 (e.g., unsubstituted phenyl optionally substituted with phenyl (mido), which links the B ring of formula AA to an NH(CO) group; It is para to the bond that

[0735] In one embodiment, one R 7 is one or more C1-C6 alkyl (e.g., methyl optionally aryl or propyl, e.g., 2-propyl) and one or more halo (e.g., F, Cl); optionally substituted phenyl, and the bond connecting ring B of formula AA to the NH(CO) group It is para to the bond connecting the B ring of formula AA to the NH(CO) group.

[0736] In one embodiment, R 6 and R 7 are each bonded to a carbon atom of the aryl ring B.

[0737] In one embodiment, R 6 and R 7 are each bonded to a carbon atom of the heteroaryl ring B. can be.

[0738] In one embodiment, R 6 is attached to carbon and R 7 is the nitrogen of heteroaryl ring B is combined with

[0739] In one embodiment, R 7 is attached to carbon and R 6 is the nitrogen of heteroaryl ring B is combined with

[0740] In certain embodiments of any of the formulas herein, R1 and R 2 Each of these is independent. and optionally substituted with one or more hydroxy, halo, oxo, or C1-C6 alkoxy. substituted C1-C6 alkyl; one or more hydroxy, halo, oxo, C1-C6 alkoxy C3-C7 cycloalkyl optionally substituted with oxy, or C1-C6 alkyl (wherein Here, C1-C6 alkoxy or C1-C6 alkyl is a group consisting of 1 to 3 hydroxy, halo, NR 8 R 9 or oxo; one or more hydroxy, ha 3- to 7-membered heterocyclohexyl optionally substituted with bromo, oxo, or C1-C6 alkyl Alkyl (wherein C1-C6 alkoxy or C1-C6 alkyl is 1 to 3 hydrogen atoms) optionally further substituted with oxy, halo, or oxo); C1-C6 haloalkyl; C1-C6 alkoxy; C1-C6 haloalkoxy; Halo; CN; CO-C1-C6 alkoxy Kill;CO-C6~C 10 Aryl;CO(5-10 membered heteroaryl);CO2C1 ~C6 alkyl;CO2C3~C8 cycloalkyl;OCOC1~C6 alkyl;OCO C6~C 10 Aryl; OCO(5- to 10-membered heteroaryl); OCO(3- to 7-membered heteroaryl) Tetracycloalkyl); C6-C 10 Aryl; 5- to 10-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5;S( O2)NR 11 R 12 ;S(O)C1-C6 alkyl; and S(O2)C1-C6 alkyl The compound is selected from the group consisting of:

[0741] In certain embodiments of any of the formulas herein, R 1 is 1-hydroxy-2-methyl 2-Hydroxy-2-propyl;Isopropyl;Methyl;Isopropyl;2-Hydroxy-2-propyl;Hydroxy 1-Hydroxymethyl;1-Hydroxyethyl;2-Hydroxyethyl;1-Hydroxy-2-propyl Pyr; 1-hydroxy-1-cyclopropyl; 1-hydroxy-1-cyclobutyl; 1- Hydroxy-1-cyclopentyl; 1-Hydroxy-1-cyclohexyl; Morpholinyl ;1,3-Dioxolan-2-yl;COCH3;COCH2CH3;2-Methoxy-2 -Propyl;Fluoro;Chloro;Phenyl;Pyridyl;Pyrazolyl;S(O2)CH3; and S(O2)NR 11 R 12 is selected from the group consisting of:

[0742] In one embodiment, R 2 Fluoro, chloro, cyano, methyl; methoxy; ethoxy 2-Hydroxy;Isopropyl;1-Hydroxy-2-methylpropan-2-yl -2-propyl;hydroxymethyl;1-hydroxyethyl;2-hydroxyethyl;1 -Hydroxy-2-propyl;1-hydroxy-1-cyclopropyl;COCH3;CO Ph; 2-methoxy-2-propyl; S(O2)CH3; and S(O2)NR 11 R 12 is selected from the group consisting of:

[0743] In one embodiment, the substituted ring B is [ka] and each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1- C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, CN, C 6~C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CON R 8 R 9 and 4- to 6-membered heterocycloalkyl, wherein C1 ~C6 alkyl, C1~C6 haloalkyl, C3~C7 cycloalkyl and 4- to 6-membered hexaalkyl Tetracycloalkyl is hydroxy, halo, CN, oxo, C1-C6 alkyl, C1- C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5- to 10-membered heteroaryl OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO (5-10 membered aryl) OCO(4- to 6-membered heterocycloalkyl), NHCOC1-C6 alkoxy Kill, NHCOC6~C 10 Aryl, NHCO (5- to 10-membered heteroaryl), NH CO(4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkynyl Each is optionally substituted with one or more independently selected substituents.

[0744] In one embodiment, the substituted ring B is [ka] and each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1- Selected from the group consisting of C6 haloalkyl, C1-C6 alkoxy, and C1-C6 haloalkoxy and wherein C1-C6 alkyl, C1-C6 haloalkyl, and C3-C7 cycloalkyl are selected from the group consisting of C1-C6 alkyl, C1-C6 haloalkyl, and C3-C7 cycloalkyl. Alkyl is one independently selected from hydroxy, halo, CN, or oxo. It is optionally substituted with the above substituents.

[0745] In one embodiment, the substituted ring B is [ka] where each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, C N, C6~C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; where R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C 6 alkoxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, CO 2C1-C6 alkyl, CO2C3-C6 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, C ONR 8 R 9 , SF5, S(O2)C1-C6 alkyl, C3-C7 cycloalkyl and 4- to 6-membered heterocycloalkyl, wherein C1-C6 alkyl is selected from 1 to 2 optionally substituted with two C1-C6 alkoxy; or R 6 and R 7 together with the atoms connecting them form a C4 to C7 carbocyclic ring or O at least one heteroatom containing one or two heteroatoms independently selected from N, and S; and independently form two 5- to 7-membered heterocyclic rings, wherein the carbocyclic or heterocyclic ring is hydroxy, halo, or the like. Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , C OOC1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 Selected independently from and optionally substituted independently with one or more substituents as defined above.

[0746] In one embodiment, the substituted ring B is [ka] where each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, C N, C6~C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; where R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C 6 alkoxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, CO 2C1-C6 alkyl, CO2C3-C6 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, C ONR 8 R 9 , SF5, S(O2)C1-C6 alkyl, C3-C7 cycloalkyl and 4- to 6-membered heterocycloalkyl, wherein C1-C6 alkyl is selected from 1 to 2 optionally substituted with two C1-C6 alkoxy; or R 6 and R 7 together with the atoms connecting them form a C4 to C7 carbocyclic ring or O at least one heteroatom containing one or two heteroatoms independently selected from N, and S; and independently form two 5- to 7-membered heterocyclic rings, wherein the carbocyclic or heterocyclic ring is hydroxy, halo, or the like. Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , C OOC1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 Selected independently from and optionally substituted independently with one or more substituents as defined above.

[0747] In one embodiment, the substituted ring B is [ka] where each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, C N, C6~C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; where R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C 6 alkoxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, CO 2C1-C6 alkyl, CO2C3-C6 cycloalkyl, OCOC1-C6 alkyl, OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered 7-membered heterocycloalkyl), C6-C 10 Aryl, 5- to 10-membered heteroaryl, C ONR 8 R 9 , SF5, S(O2)C1-C6 alkyl, C3-C7 cycloalkyl and 4- to 6-membered heterocycloalkyl, wherein C1-C6 alkyl is selected from 1 to 2 Optionally substituted with one C1-C6 alkoxy.

[0748] In one embodiment, the substituted ring B is [ka] where each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, C N, C6~C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; Here, each R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1- C6 alkoxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, C O2C1-C6 alkyl, CO2C3-C6 cycloalkyl, OCOC1-C6 alkyl , OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered ~7-membered heterocycloalkyl), C6-C 10 aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 , SF5, S(O2) C1-C6 alkyl, C3-C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl, wherein C1-C6 alkyl is selected from 1 to optionally substituted with two C1-C6 alkoxy; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C7 carbocyclic ring or independently selected from O, N, and S At least one 5- to 7-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR8 R 9 and optionally one or more substituents independently selected from are optionally independently substituted.

[0749] In one embodiment, the substituted ring B is [ka] where each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, C N, C6~C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; Here, each R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1- C6 alkoxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, C O2C1-C6 alkyl, CO2C3-C6 cycloalkyl, OCOC1-C6 alkyl , OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered ~7-membered heterocycloalkyl), C6-C 10 aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 , SF5, S(O2) C1-C6 alkyl, C3-C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl, wherein C1-C6 alkyl is selected from 1 to optionally substituted with two C1-C6 alkoxy; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C7 carbocyclic ring or independently selected from O, N, and S At least one 5- to 7-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from are optionally independently substituted.

[0750] In one embodiment, the substituted ring B is [ka] where each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, C N, C6~C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; Here, each R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1- C6 alkoxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, C O2C1-C6 alkyl, CO2C3-C6 cycloalkyl, OCOC1-C6 alkyl , OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered ~7-membered heterocycloalkyl), C6-C 10 aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 , SF5, S(O2) C1-C6 alkyl, C3-C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl, wherein C1-C6 alkyl is selected from 1 to optionally substituted with two C1-C6 alkoxy; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C7 carbocyclic ring or independently selected from O, N, and S At least one 5- to 7-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is selected from the group consisting of hydroxy, halo, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6 ~C 10 Aryl, and CONR 8 R 9 and optionally one or more substituents independently selected from are optionally independently substituted.

[0751] In one embodiment, the substituted ring B is [ka] where each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, C N, C6~C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; Here, each R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1- C6 alkoxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, C O2C1-C6 alkyl, CO2C3-C6 cycloalkyl, OCOC1-C6 alkyl , OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered ~7-membered heterocycloalkyl), C6-C 10 aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 , SF5, S(O2) C1-C6 alkyl, C3-C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl, wherein C1-C6 alkyl is selected from 1 to optionally substituted with two C1-C6 alkoxy; or R 6 and R 7 together with the atoms connecting them form a C4 to C7 carbocyclic ring or O at least one heteroatom containing one or two heteroatoms independently selected from N, and S; and independently form two 5- to 7-membered heterocyclic rings, wherein the carbocyclic or heterocyclic ring is hydroxy, halo, or the like. Oxo, C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , C OOC1-C6 alkyl, C6-C 10 Aryl, and CONR 8 R 9 Selected independently from and optionally substituted independently with one or more substituents as defined above.

[0752] In one embodiment, the substituted ring B is [ka] where each R 6 are independently C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halo, C N, C6~C 10 Aryl, 5- to 10-membered heteroaryl, CO-C1-C6 alkyl; CONR 8 R 9 and 4- to 6-membered heterocycloalkyl; Here, C1 to C6 alkyl, C1 to C6 haloalkyl, C3 to C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl include hydroxy, halo, CN, oxo, C1-C6 alkyl, Alkyl, C1-C6 alkoxy, NR 8 R 9 , =NR 10 , COOC1-C6 alkyl, CONR 8 R 9 , 4- to 6-membered heterocycloalkyl, C6-C 10 Aryl, 5-10 members 1-membered heteroaryl, OCOC1-C6 alkyl, OCOC6-C 10 Aryl, OCO( 5- to 10-membered heteroaryl), OCO (4- to 6-membered heterocycloalkyl), NHCO C1-C6 alkyl, NHCOC6-C 10 Aryl, NHCO (5- to 10-membered heteroaryl) aryl), NHCO (4- to 6-membered heterocycloalkyl), and NHCOC2-C6 alkyl optionally substituted with one or more substituents each independently selected from: quinyl; Here, each R 7 are independently C1-C6 alkyl, C1-C6 haloalkyl, C1- C6 alkoxy, C1-C6 haloalkoxy, halo, CN, COC1-C6 alkyl, C O2C1-C6 alkyl, CO2C3-C6 cycloalkyl, OCOC1-C6 alkyl , OCOC6~C 10 Aryl, OCO (5- to 10-membered heteroaryl), OCO (3-membered ~7-membered heterocycloalkyl), C6-C 10 aryl, 5- to 10-membered heteroaryl, CONR 8 R 9 , SF5, S(O2) C1-C6 alkyl, C3-C7 cycloalkyl and and 4- to 6-membered heterocycloalkyl, wherein C1-C6 alkyl is selected from 1 to optionally substituted with two C1-C6 alkoxy; or R on the adjacent atom 6 and R 7 At least one pair of together, at least one C4-C7 carbocyclic ring or independently selected from O, N, and S At least one 5- to 7-membered heterocyclic ring containing one or two heteroatoms is independently wherein the carbocyclic or heterocyclic ring is hydroxy, hydroxymethyl, halo, oxo, , C1-C6 alkyl, C1-C6 alkoxy, NR 8 R 9 , CH2NR 8 R 9 , =NR 10 , COOC1~C6 alkyl, C6~C 10 Aryl, and CONR 8 R 9 Independence from is optionally substituted independently with one or more substituents selected from the following:

[0753] base R 3 In one embodiment, R 3 is hydrogen, C1-C6 alkyl, and [ka] wherein the C1-C2 alkylene group is optionally substituted with oxo.

[0754] In one embodiment, R 3 is hydrogen.

[0755] In one embodiment, R 3 is cyano.

[0756] In one embodiment, R 3 is hydroxy.

[0757] In one embodiment, R 3 is C1-C6 alkoxy. R 3 is C1-C6 alkyl.

[0758] In one embodiment, R 3 is methyl.

[0759] In one embodiment, R 3 teeth, [ka] wherein the C1-C2 alkylene group is optionally substituted with oxo.

[0760] In one embodiment, R 3 Ha-CH2R 14 is.

[0761] In one embodiment, R 3 HA-C(O)R 14 is.

[0762] In one embodiment, R 3 -CH2CH2R 14 is.

[0763] In one embodiment, R 3 Ha-CHR 14 It is CH3.

[0764] In one embodiment, R 3 is -CH2C(O)R 14 is.

[0765] In one embodiment, R 3 is -C(O)CH2R 14 is.

[0766] In one embodiment, R 3 is CO2C1-C6 alkyl.

[0767] base R 14 In one embodiment, R 14 is hydrogen, C1-C6 alkyl, 5- to 10-membered monocyclic or bicyclic heteroaryl or C6-C 10 monocyclic or bicyclic aryl, wherein each C1-C6 alkyl, aryl or heteroaryl is selected from one or two R 6 At the discretion of are optionally independently substituted.

[0768] In one embodiment, R 14 is hydrogen or C1-C6 alkyl.

[0769] In one embodiment, R 14 is hydrogen, a 5- to 10-membered monocyclic or bicyclic heterocyclic ring Reel or C6~C 10 monocyclic or bicyclic aryl, wherein each C1-C6 aryl alkyl, aryl or heteroaryl is one or two R 6 Optionally placed independently It will be exchanged.

[0770] In one embodiment, R 14 is hydrogen.

[0771] In one embodiment, R 14 is C1-C6 alkyl.

[0772] In one embodiment, R 14 is methyl.

[0773] In one embodiment, R 14 is one or two R 6 Optionally independently substituted with and 5- to 10-membered monocyclic or bicyclic heteroaryl.

[0774] In one embodiment, R 14 is one or two R 6Optionally independently substituted with C6~C 10 It is a monocyclic or bicyclic aryl.

[0775] Partial S(=O)(NHR 3 )=N- In one embodiment, the moiety S(=O)(NHR 3 The sulfur in )=N- is (S) steric To have knowledge.

[0776] In one embodiment, the moiety S(=O)(NHR 3 The sulfur in )=N- is (R) stereoisomerized To have knowledge.

[0777] base R 10 In one embodiment, R 10 is C1-C6 alkyl.

[0778] In one embodiment, R 10 is methyl.

[0779] In one embodiment, R 10 is ethyl.

[0780] base R 8 and R 9 In one embodiment, R 8 and R 9 Each occurrence of is independently hydrogen , C1-C6 alkyl, (C=NR 13 )NR 11 R 12 , S(O2)C1~C6 alkyl Le, S(O2)NR 11 R 12 , C.O.R. 13 , CO2R 13 and CONR 11 R 12 from wherein C1-C6 alkyl is selected from one or more of hydroxy, halo, C1-C6 alkyl, Alkoxy, C6-C10 Aryl, 5- to 10-membered heteroaryl, C3-C7 cycloaryl optionally substituted with alkyl or 3- to 7-membered heterocycloalkyl; or R 8 and R 9 teeth , together with the nitrogen to which they are attached, and one or more Forms a 3- to 7-membered ring optionally containing a heteroatom.

[0781] In one embodiment, R 8 and R 9 Each occurrence of is independently hydrogen , C1-C6 alkyl, (C=NR 13 )NR 11 R 12 , S(O2)C1~C6 alkyl Le, S(O2)NR 11 R 12 , C.O.R. 13 , CO2R 13 and CONR 11 R 12 from wherein C1-C6 alkyl is selected from one or more of hydroxy, halo, C1-C6 alkyl, Alkoxy, C6-C 10 Aryl, 5- to 10-membered heteroaryl, C3-C7 cycloaryl optionally substituted with alkyl or 3- to 7-membered heterocycloalkyl; or R 8 and R 9 teeth , together with the nitrogen to which they are attached, and one or more Forms a 3- to 7-membered ring optionally containing a heteroatom.

[0782] In one embodiment, R 8 and R 9 each occurrence is hydrogen, In some embodiments, each R 8 Each occurrence of is hydrogen, and each R 9 appears Each is a C1 to C6 alkyl.

[0783] In some embodiments, each R 8 Each occurrence of is hydrogen, and each R 9 appears Each is methyl.

[0784] In some embodiments, each R 8 Each occurrence of is hydrogen, and each R 9 appears Each is ethyl.

[0785] In one embodiment, R 8 and R 9 Each occurrence of is methyl.

[0786] In one embodiment, R 8 and R 9 Each occurrence of is ethyl.

[0787] In one embodiment, R 8 and R 9 together with the nitrogen to which they are attached, It forms a membered ring.

[0788] In one embodiment, R 8 and R 9 together with the nitrogen to which they are attached, It forms a membered ring.

[0789] In one embodiment, R 8 and R 9 together with the nitrogen to which they are attached, It forms a membered ring.

[0790] In one embodiment, R 8 and R 9 together with the nitrogen to which they are attached. form a six-membered ring optionally containing one or more oxygen atoms in addition to the nitrogen to which they are attached do.

[0791] In one embodiment, R 8 and R 9 together with the nitrogen to which they are attached. form a six-membered ring optionally containing one or more nitrogen atoms in addition to the nitrogen to which they are attached do.

[0792] In one embodiment, R 8 and R 9 together with the nitrogen to which they are attached, It forms a membered ring.

[0793] base R 13 In one embodiment, R 13 is C1-C6 alkyl.

[0794] In one embodiment, R 13 is methyl.

[0795] In one embodiment, R 13 is ethyl.

[0796] In one embodiment, R 13 is C6~C 10 It is aryl.

[0797] In one embodiment, R 13 is phenyl.

[0798] In one embodiment, R 13 is a 5- to 10-membered heteroaryl.

[0799] base R 11 and R 12 In one embodiment, R 11 and R 12 Each occurrence of It is selected from hydrogen and C1-C6 alkyl.

[0800] In one embodiment, R 11 and R 12 Each occurrence of is hydrogen , In some embodiments, each R 11 Each occurrence of is hydrogen, and each R 12 appears Each is a C1 to C6 alkyl.

[0801] In some embodiments, each R 11 Each occurrence of is hydrogen, and each R 12 appears Each time, it is methyl.

[0802] In some embodiments, each R 11 Each occurrence of is hydrogen, and each R 12 appears Each time, it is ethyl.

[0803] In one embodiment, R 11 and R 12 Each occurrence of is methyl do.

[0804] In one embodiment, R 11 and R 12 Each occurrence of is ethyl. do.

[0805] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with oxy; C1-C6 haloalkyl; C1-C6 alkoxy Koxy;C1-C6 haloalkoxy;Halo;CN;NO2;COC1-C6 alkyl;C O-C6~C 10 Aryl; CO(5- to 10-membered heteroaryl); CO2C1-C6 alkyl;CO2C3-C8 cycloalkyl;OCOC1-C6 alkyl;OCOC6-C 10 Aryl; OCO(5- to 10-membered heteroaryl); OCO(3- to 7-membered heterocyclic C6-C 10 Aryl; 5- to 10-membered heteroaryl; NH2; NHC1 ~C6 alkyl; N(C1~C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2 ) C1 to C6 alkyl.

[0806] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0807] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0808] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0809] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0810] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0811] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0812] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0813] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0814] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0815] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0816] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0817] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0818] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0819] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0820] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0821] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0822] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0823] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0824] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0825] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0826] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0827] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0828] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0829] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0830] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0831] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0832] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0833] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0834] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0835] The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0836] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0837] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R 9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl; CO-5-10 membered Heteroaryl;CO2C1-C6 alkyl;CO2C3-C8 cycloalkyl;OCO C1-C6 alkyl;OCOC6-C 10 Aryl; OCO (5- to 10-membered heteroaryl OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-10 members Membered heteroaryl;NH2;NHC1-C6 alkyl;N(C1-C6 alkyl)2;C ONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0838] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0839] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with hydroxy; one or more NR 8 R 9 C1~ to be substituted with C6 alkyl; one or more NR 8 R9 3- to 7-membered heterocycloalkyl substituted with C 1-C6 haloalkyl;C1-C6 alkoxy;C1-C6 haloalkoxy;Halo;CN ;NO2;COC1~C6 alkyl;CO-C6~C 10 Aryl;CO(5-10 membered) Heteroaryl;CO₂C₁-C₆ alkyl;CO₂C₃-C₈ cycloalkyl;OC OC1~C6 alkyl;OCOC6~C 10 Aryl; OCO (5- to 10-membered heteroaryl) OCO(3- to 7-membered heterocycloalkyl); C6-C 10 Aryl; 5-1 membered 0-membered heteroaryl; NH2; NHC1-C6 alkyl; N(C1-C6 alkyl)2; CONR 8 R 9 ;SF5; and S(O2)C1-C6 alkyl.

[0840] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;(Dimethylamino)methyl;1-(Dimethylamino)methyl (O) Ethyl; Fluoro; Chloro; Phenyl; Pyridyl; Pyrazolyl; and S(O2)CH 3 are selected.

[0841] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with oxy; C1-C6 haloalkyl; C1-C6 alkoxy Koxy;C1-C6 haloalkoxy;Halo;CN;NO2;COC1-C6 alkyl;C O-C6~C 10 Aryl; CO(5- to 10-membered heteroaryl); CO2C1-C6 alkyl;CO2C3-C8 cycloalkyl;OCOC1-C6 alkyl;OCOC6-C 10 Aryl; OCO(5- to 10-membered heteroaryl); OCO(3- to 7-membered heterocyclic C6-C 10 Aryl; 5- to 10-membered heteroaryl; NH2; NHC1 ~C6 alkyl; N(C1~C6 alkyl)2; CONR 8 R 9 ;SF5;One or more N R 8 R 9and S(O2)C1-C6 alkyl. will be done.

[0842] The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolane-2-yl;(dimethylamino)methyl;1,3-Dioxolane-2-yl; Fluoro;COCH3;COCH2CH3;2-Methoxy-2-propyl;Fluoro;Chloro; It is selected from phenyl; pyridyl; pyrazolyl; and S(O2)CH3.

[0843] The substituted ring A is [ka] and; R 1 teeth, C1-C6 alkyl optionally substituted with one or more hydroxy; C3-C7 cycloalkyl optionally substituted with hydroxy; C3-C7 cycloalkyl optionally substituted with one or more hydroxy; Optionally substituted 3- to 7-membered heterocycloalkyl; C substituted with one or more oxo 1-C6 alkyl; C3-C7 cycloalkyl substituted with one or more oxo; one or more C1-C6 alkyl substituted with one or more C1-C6 alkoxy; C3-C7 cycloalkyl substituted with oxy; C1-C6 haloalkyl; C1-C6 alkoxy Koxy;C1-C6 haloalkoxy;Halo;CN;NO2;COC1-C6 alkyl;C O-C6~C 10 Aryl; CO(5- to 10-membered heteroaryl); CO2C1-C6 alkyl;CO2C3-C8 cycloalkyl;OCOC1-C6 alkyl;OCOC6-C 10 Aryl; OCO(5- to 10-membered heteroaryl); OCO(3- to 7-membered heterocyclic C6-C 10 Aryl; 5- to 10-membered heteroaryl; NH2; NHC1 ~C6 alkyl; N(C1~C6 alkyl)2; CONR 8 R 9 ;SF5;One or more N R 8 R 9 and S(O2)C1-C6 alkyl. will be done.

[0844] The substituted ring A is [ka] and; R 1 teeth, 1-Hydroxy-2-methylpropan-2-yl;Methyl;Isopropyl;2-Hydroxy 2-Propyl; Hydroxymethyl; 1-Hydroxyethyl; 2-Hydroxyethyl; 1-Hydroxy-2-propyl;1-Hydroxy-1-cyclopropyl;1-Hydroxy -1-Cyclobutyl;1-Hydroxy-1-cyclopentyl;1-Hydroxy-1-cyclopentyl 1,3-Dioxolan-2-yl;C1H3;C1H2;C1H2 CH3;2-Methoxy-2-propyl;Fluoro;Chloro;Phenyl;Pyridyl;Pyrazo (dimethylamino)methyl; and S(O2)CH3.

[0845] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C6~C 10 is aryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a 5- to 10-membered heteroaryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is SF5; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is S(O2)C1-C6 alkyl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a halo; R 1is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is a halo; R 1 is C1-C6 alkyl optionally substituted with one or more oxo, and R 2 is methyl; R 1 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is a halo; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is C6~C 10 is aryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is SF5.

[0846] R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)C1-C6 alkyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a halo; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is a halo; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; R 2 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 1 is C1-C6 alkyl; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is C1-C6 alkyl; R 2is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is a halo.

[0847] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is 1-hydroxy-2-methylpropan-2-yl and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is isopropyl; R 1 is 2-hydroxy-2-propyl, and R 2 is 2-hydroxy-2-propyl can be; R 1 is 2-hydroxy-2-propyl, and R 2 is 1-hydroxyethyl; R 1 is hydroxymethyl and R 2 is methyl; R 1 is 1-hydroxyethyl, and R 2 is methyl; R 1 is 2-hydroxyethyl, and R 2 is methyl; R 1 is 1-hydroxy-2-propyl, and R 2 is methyl; R 1is 2-hydroxy-2-propyl, and R 2 is phenyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyridyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyrazolyl; R 1 is 2-hydroxy-2-propyl, and R 2 is S(O2)CH3; R 1 is 2-hydroxy-2-propyl, and R 2 is chloro; R 1 is 2-hydroxy-2-propyl, and R 2 is fluoro; R 1 is 1-hydroxy-1-cyclopropyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclobutyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclopentyl and R 2 is methyl; R 1 is 1-hydroxy-1-cyclohexyl, and R 2 is methyl; R 1 is morpholinyl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is fluoro; R 1 is 1,3-dioxolan-2-yl and R 2 is chloro; R 1 is COCH3 and R 2 is methyl; R 1 is 2-methoxy-2-propyl, and R 2 is methyl; R 2 is (dimethylamino)methyl, and R 1 is methyl. R 2 is 1-hydroxy-2-methylpropan-2-yl and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is isopropyl; R 2 is 2-hydroxy-2-propyl, and R 1 is 1-hydroxyethyl; R 2 is hydroxymethyl and R 1 is methyl; R 2 is 1-hydroxyethyl, and R 1 is methyl; R 2 is 2-hydroxyethyl, and R 1 is methyl; R 2 is 1-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is phenyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyridyl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyrazolyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)CH3; R 2 is 2-hydroxy-2-propyl, and R 1 is chloro; R 2 is 2-hydroxy-2-propyl, and R 1 is fluoro; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is 1-hydroxy-1-cyclopropyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclobutyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclopentyl and R 1 is methyl; R 2 is 1-hydroxy-1-cyclohexyl, and R 1 is methyl; R 2 is morpholinyl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is fluoro; R 2 is 1,3-dioxolan-2-yl and R 1 is chloro; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; R 2 is COCH3 and R 1 is methyl; or R 2 is 2-methoxy-2-propyl, and R 1 is methyl.

[0848] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C6~C 10 is aryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a 5- to 10-membered heteroaryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is SF5; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is S(O2)C1-C6 alkyl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R2 is a halo; R 1 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is a halo; R 1 is C1-C6 alkyl optionally substituted with one or more oxo, and R 2 is methyl; R 1 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is a halo; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is C6~C 10 is aryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R1 is a 5- to 10-membered heteroaryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is SF5.

[0849] R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)C1-C6 alkyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a halo; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is a halo; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; or R 2 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 1 is C1-C6 alkyl.

[0850] R 2 is one or more NR 8 R 9C1-C6 alkyl optionally substituted with R 1 is C1-C6 alkyl; or R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is a halo.

[0851] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is 1-hydroxy-2-methylpropan-2-yl and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is isopropyl; R 1 is 2-hydroxy-2-propyl, and R 2 is 2-hydroxy-2-propyl can be; R 1 is 2-hydroxy-2-propyl, and R 2 is 1-hydroxyethyl; R 1 is hydroxymethyl and R 2 is methyl; R 1 is 1-hydroxyethyl, and R 2 is methyl; R 1 is 2-hydroxyethyl, and R 2 is methyl; R 1 is 1-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is phenyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyridyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyrazolyl; R 1 is 2-hydroxy-2-propyl, and R 2 is S(O2)CH3; R 1 is 2-hydroxy-2-propyl, and R 2 is chloro; R 1 is 2-hydroxy-2-propyl, and R 2 is fluoro; R 1 is 1-hydroxy-1-cyclopropyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclobutyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclopentyl and R 2 is methyl; R 1 is 1-hydroxy-1-cyclohexyl, and R 2 is methyl; R 1 is morpholinyl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is fluoro; R 1is 1,3-dioxolan-2-yl and R 2 is chloro; R 1 is COCH3 and R 2 is methyl; R 1 is 2-methoxy-2-propyl, and R 2 is methyl; R 1 is (dimethylamino)methyl, and R 2 is methyl.

[0852] R 2 is 1-hydroxy-2-methylpropan-2-yl and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is isopropyl; R 2 is 2-hydroxy-2-propyl, and R 1 is 1-hydroxyethyl; R 2 is hydroxymethyl and R 1 is methyl; R 2 is 1-hydroxyethyl, and R 1 is methyl; R 2 is 2-hydroxyethyl, and R 1 is methyl; R 2 is 1-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is phenyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R2 is 2-hydroxy-2-propyl, and R 1 is pyridyl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyrazolyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)CH3; R 2 is 2-hydroxy-2-propyl, and R 1 is chloro; R 2 is 2-hydroxy-2-propyl, and R 1 is fluoro; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is 1-hydroxy-1-cyclopropyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclobutyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclopentyl and R 1 is methyl; R 2 is 1-hydroxy-1-cyclohexyl, and R 1 is methyl; R 2 is morpholinyl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is fluoro; R 2is 1,3-dioxolan-2-yl and R 1 is chloro; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; R 2 is (dimethylamino)methyl, and R 1 is methyl; R 2 is COCH3 and R 1 is methyl; or R 2 is 2-methoxy-2-propyl, and R 1 is methyl.

[0853] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C6~C 10 is aryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a 5- to 10-membered heteroaryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R2 is SF5; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is S(O2)C1-C6 alkyl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a halo; R 1 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is a halo; R 1 is C1-C6 alkyl optionally substituted with one or more oxo, and R 2 is methyl; R 1 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2is a halo; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is C6~C 10 is aryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is SF5.

[0854] R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)C1-C6 alkyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a halo; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is a halo; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R1 is C1-C6 alkyl; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is a halo; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; or R 2 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 1 is C1-C6 alkyl.

[0855] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is 1-hydroxy-2-methylpropan-2-yl and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is isopropyl; R 1 is 2-hydroxy-2-propyl, and R 2 is 2-hydroxy-2-propyl can be; R 1 is 2-hydroxy-2-propyl, and R 2 is 1-hydroxyethyl; R 1is hydroxymethyl and R 2 is methyl; R 1 is 1-hydroxyethyl, and R 2 is methyl; R 1 is 2-hydroxyethyl, and R 2 is methyl; R 1 is 1-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is phenyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyridyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyrazolyl; R 1 is 2-hydroxy-2-propyl, and R 2 is S(O2)CH3; R 1 is 2-hydroxy-2-propyl, and R 2 is chloro; R 1 is 2-hydroxy-2-propyl, and R 2 is fluoro; R 1 is 1-hydroxy-1-cyclopropyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclobutyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclopentyl and R 2 is methyl; R 1 is 1-hydroxy-1-cyclohexyl, and R 2 is methyl; R 1 is morpholinyl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is fluoro; R 1 is 1,3-dioxolan-2-yl and R 2 is chloro; R 1 is COCH3 and R 2 is methyl; R 1 is 2-methoxy-2-propyl, and R 2 is methyl; R 1 is (dimethylamino)methyl, and R 2 is methyl; R 2 is 1-hydroxy-2-methylpropan-2-yl and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is isopropyl; R 2 is 2-hydroxy-2-propyl, and R 1 is 1-hydroxyethyl; R 2 is hydroxymethyl and R 1 is methyl; R 2 is 1-hydroxyethyl, and R 1 is methyl; R 2 is 2-hydroxyethyl, and R 1 is methyl; R 2 is 1-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R1 is phenyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyridyl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyrazolyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)CH3; R 2 is 2-hydroxy-2-propyl, and R 1 is chloro; R 2 is 2-hydroxy-2-propyl, and R 1 is fluoro; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is 1-hydroxy-1-cyclopropyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclobutyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclopentyl and R 1 is methyl; R 2 is 1-hydroxy-1-cyclohexyl, and R 1 is methyl; R 2 is morpholinyl and R 1 is methyl; R 2is 1,3-dioxolan-2-yl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is fluoro; R 2 is 1,3-dioxolan-2-yl and R 1 is chloro; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; R 2 is (dimethylamino)methyl, and R 1 is methyl; R 2 is COCH3 and R 1 is methyl; or R 2 is 2-methoxy-2-propyl, and R 1 is methyl.

[0856] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C6~C 10 is aryl; R 1is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a 5- to 10-membered heteroaryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is SF5; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is S(O2)C1-C6 alkyl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a halo; R 1 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is a halo; R 1 is C1-C6 alkyl optionally substituted with one or more oxo, and R 2 is methyl; R 1 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9C1-C6 alkyl optionally substituted with R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is a halo; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is C6~C 10 is aryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is SF5.

[0857] R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)C1-C6 alkyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a halo; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is C1-C6 alkyl; R 2is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is a halo; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is C1-C6 alkyl; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is a halo; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; or R 2 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 1 is C1-C6 alkyl.

[0858] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is 1-hydroxy-2-methylpropan-2-yl and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is isopropyl; R1 is 2-hydroxy-2-propyl, and R 2 is 2-hydroxy-2-propyl can be; R 1 is 2-hydroxy-2-propyl, and R 2 is 1-hydroxyethyl; R 1 is hydroxymethyl and R 2 is methyl; R 1 is 1-hydroxyethyl, and R 2 is methyl; R 1 is 2-hydroxyethyl, and R 2 is methyl; R 1 is 1-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is phenyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyridyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyrazolyl; R 1 is 2-hydroxy-2-propyl, and R 2 is S(O2)CH3; R 1 is 2-hydroxy-2-propyl, and R 2 is chloro; R 1 is 2-hydroxy-2-propyl, and R 2 is fluoro; R 1 is 1-hydroxy-1-cyclopropyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclobutyl, and R 2 is methyl; R 1is 1-hydroxy-1-cyclopentyl and R 2 is methyl; R 1 is 1-hydroxy-1-cyclohexyl, and R 2 is methyl; R 1 is morpholinyl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is fluoro; R 1 is 1,3-dioxolan-2-yl and R 2 is chloro; R 1 is COCH3 and R 2 is methyl; R 1 is 2-methoxy-2-propyl, and R 2 is methyl; R 1 is (dimethylamino)methyl, and R 2 is methyl.

[0859] R 2 is 1-hydroxy-2-methylpropan-2-yl and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is isopropyl; R 2 is 2-hydroxy-2-propyl, and R 1 is 1-hydroxyethyl; R 2 is hydroxymethyl and R 1 is methyl; R 2 is 1-hydroxyethyl, and R1 is methyl; R 2 is 2-hydroxyethyl, and R 1 is methyl; R 2 is 1-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is phenyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyridyl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyrazolyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)CH3; R 2 is 2-hydroxy-2-propyl, and R 1 is chloro; R 2 is 2-hydroxy-2-propyl, and R 1 is fluoro; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is 1-hydroxy-1-cyclopropyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclobutyl, and R 1 is methyl; R 2is 1-hydroxy-1-cyclopentyl and R 1 is methyl; R 2 is 1-hydroxy-1-cyclohexyl, and R 1 is methyl; R 2 is morpholinyl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is fluoro; R 2 is 1,3-dioxolan-2-yl and R 1 is chloro; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; R 2 is (dimethylamino)methyl, and R 1 is methyl; R 2 is COCH3 and R 1 is methyl; or R 2 is 2-methoxy-2-propyl, and R 1 is methyl.

[0860] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2is C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C6~C 10 is aryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a 5- to 10-membered heteroaryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is SF5; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is S(O2)C1-C6 alkyl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a halo; R 1 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is a halo; R 1 is C1-C6 alkyl optionally substituted with one or more oxo, and R 2 is methyl; R 1 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is a halo; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is C6~C 10 is aryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is SF5.

[0861] R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)C1-C6 alkyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a halo; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is a halo; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is C1-C6 alkyl; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is a halo; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; or R 2 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 1 is C1-C6 alkyl.

[0862] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is 1-hydroxy-2-methylpropan-2-yl and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is isopropyl; R 1 is 2-hydroxy-2-propyl, and R 2 is 2-hydroxy-2-propyl can be; R 1 is 2-hydroxy-2-propyl, and R 2 is 1-hydroxyethyl; R 1 is hydroxymethyl and R 2 is methyl; R 1 is 1-hydroxyethyl, and R 2 is methyl; R 1 is 2-hydroxyethyl, and R 2 is methyl; R 1 is 1-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is phenyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyridyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyrazolyl; R 1 is 2-hydroxy-2-propyl, and R 2 is S(O2)CH3; R 1 is 2-hydroxy-2-propyl, and R 2 is chloro; R 1 is 2-hydroxy-2-propyl, and R 2 is fluoro; R1 is 1-hydroxy-1-cyclopropyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclobutyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclopentyl and R 2 is methyl; R 1 is 1-hydroxy-1-cyclohexyl, and R 2 is methyl; R 1 is morpholinyl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is fluoro; R 1 is 1,3-dioxolan-2-yl and R 2 is chloro; R 1 is COCH3 and R 2 is methyl; R 1 is 2-methoxy-2-propyl, and R 2 is methyl; R 1 is (dimethylamino)methyl, and R 2 is methyl.

[0863] R 2 is 1-hydroxy-2-methylpropan-2-yl and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is isopropyl; R 2is 2-hydroxy-2-propyl, and R 1 is 1-hydroxyethyl; R 2 is hydroxymethyl and R 1 is methyl; R 2 is 1-hydroxyethyl, and R 1 is methyl; R 2 is 2-hydroxyethyl, and R 1 is methyl; R 2 is 1-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is phenyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyridyl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyrazolyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)CH3; R 2 is 2-hydroxy-2-propyl, and R 1 is chloro; R 2 is 2-hydroxy-2-propyl, and R 1 is fluoro; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2is 1-hydroxy-1-cyclopropyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclobutyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclopentyl and R 1 is methyl; R 2 is 1-hydroxy-1-cyclohexyl, and R 1 is methyl; R 2 is morpholinyl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is fluoro; R 2 is 1,3-dioxolan-2-yl and R 1 is chloro; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; R 2 is (dimethylamino)methyl, and R 1 is methyl; R 2 is COCH3 and R 1 is methyl; or R 2 is 2-methoxy-2-propyl, and R 1 is methyl.

[0864] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R1 and R 2 is one of the following combinations: R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C6~C 10 is aryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a 5- to 10-membered heteroaryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is SF5; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is S(O2)C1-C6 alkyl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a halo; R 1 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is a halo; R 1 is C1-C6 alkyl optionally substituted with one or more oxo, and R 2 is methyl; R 1 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is a halo; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is C6~C 10 is aryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is SF5.

[0865] R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)C1-C6 alkyl; R 2is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a halo; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is a halo; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is C1-C6 alkyl; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is a halo; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; or R 2 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 1 is C1-C6 alkyl.

[0866] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is 1-hydroxy-2-methylpropan-2-yl and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is isopropyl; R 1 is 2-hydroxy-2-propyl, and R 2 is 2-hydroxy-2-propyl can be; R 1 is 2-hydroxy-2-propyl, and R 2 is 1-hydroxyethyl; R 1 is hydroxymethyl and R 2 is methyl; R 1 is 1-hydroxyethyl, and R 2 is methyl; R 1 is 2-hydroxyethyl, and R 2 is methyl; R 1 is 1-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is phenyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyridyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyrazolyl; R 1 is 2-hydroxy-2-propyl, and R 2 is S(O2)CH3; R 1 is 2-hydroxy-2-propyl, and R 2 is chloro; R 1 is 2-hydroxy-2-propyl, and R 2 is fluoro; R 1 is 1-hydroxy-1-cyclopropyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclobutyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclopentyl and R 2 is methyl; R 1 is 1-hydroxy-1-cyclohexyl, and R 2 is methyl; R 1 is morpholinyl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is fluoro; R 1 is 1,3-dioxolan-2-yl and R 2 is chloro; R 1 is COCH3 and R 2 is methyl; R 1 is 2-methoxy-2-propyl, and R 2 is methyl; R 1 is (dimethylamino)methyl, and R 2 is methyl.

[0867] R 2 is 1-hydroxy-2-methylpropan-2-yl and R 1 is methyl; R2 is 2-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is isopropyl; R 2 is 2-hydroxy-2-propyl, and R 1 is 1-hydroxyethyl; R 2 is hydroxymethyl and R 1 is methyl; R 2 is 1-hydroxyethyl, and R 1 is methyl; R 2 is 2-hydroxyethyl, and R 1 is methyl; R 2 is 1-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is phenyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyridyl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyrazolyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)CH3; R 2 is 2-hydroxy-2-propyl, and R 1 is chloro; R 2 is 2-hydroxy-2-propyl, and R1 is fluoro; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is 1-hydroxy-1-cyclopropyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclobutyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclopentyl and R 1 is methyl; R 2 is 1-hydroxy-1-cyclohexyl, and R 1 is methyl; R 2 is morpholinyl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is fluoro; R 2 is 1,3-dioxolan-2-yl and R 1 is chloro; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; R 2 is (dimethylamino)methyl, and R 1 is methyl; R 2 is COCH3 and R 1 is methyl; or R 2 is 2-methoxy-2-propyl, and R 1 is methyl.

[0868] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C6~C 10 is aryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a 5- to 10-membered heteroaryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is SF5; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is S(O2)C1-C6 alkyl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a halo; R 1 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 2 is C1-C6 alkyl; R 1is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 is a halo; R 1 is C1-C6 alkyl optionally substituted with one or more oxo, and R 2 is methyl; R 1 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is C1-C6 alkyl; R 1 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 2 is a halo; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is C6~C 10 is aryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is SF5.

[0869] R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is S(O2)C1-C6 alkyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a halo; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is C1-C6 alkyl; R 2 is a 3- to 7-membered heterocycloalkane optionally substituted with one or more hydroxy groups Kill and R 1 is a halo; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is C1-C6 alkyl; R 2 is one or more NR 8 R 9 C1-C6 alkyl optionally substituted with R 1 is a halo; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; or R 2 is a C1-C6 alkyl group optionally substituted with one or more C1-C6 alkoxy groups. R 1 is C1-C6 alkyl.

[0870] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is 1-hydroxy-2-methylpropan-2-yl and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is isopropyl; R 1 is 2-hydroxy-2-propyl, and R 2 is 2-hydroxy-2-propyl can be; R 1 is 2-hydroxy-2-propyl, and R 2 is 1-hydroxyethyl; R 1 is hydroxymethyl and R 2 is methyl; R 1 is 1-hydroxyethyl, and R 2 is methyl; R 1 is 2-hydroxyethyl, and R 2 is methyl; R 1 is 1-hydroxy-2-propyl, and R 2 is methyl; R 1 is 2-hydroxy-2-propyl, and R 2 is phenyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyridyl; R 1 is 2-hydroxy-2-propyl, and R 2 is pyrazolyl; R 1 is 2-hydroxy-2-propyl, and R 2 is S(O2)CH3; R 1 is 2-hydroxy-2-propyl, and R 2 is chloro; R 1 is 2-hydroxy-2-propyl, and R 2 is fluoro; R 1 is 1-hydroxy-1-cyclopropyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclobutyl, and R 2 is methyl; R 1 is 1-hydroxy-1-cyclopentyl and R 2 is methyl; R 1 is 1-hydroxy-1-cyclohexyl, and R 2 is methyl; R 1 is morpholinyl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is methyl; R 1 is 1,3-dioxolan-2-yl and R 2 is fluoro; R 1 is 1,3-dioxolan-2-yl and R 2 is chloro; R 1 is COCH3 and R 2 is methyl; R 1 is 2-methoxy-2-propyl, and R 2 is methyl; R 1 is (dimethylamino)methyl, and R2 is methyl.

[0871] R 2 is 1-hydroxy-2-methylpropan-2-yl and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is isopropyl; R 2 is 2-hydroxy-2-propyl, and R 1 is 1-hydroxyethyl; R 2 is hydroxymethyl and R 1 is methyl; R 2 is 1-hydroxyethyl, and R 1 is methyl; R 2 is 2-hydroxyethyl, and R 1 is methyl; R 2 is 1-hydroxy-2-propyl, and R 1 is methyl; R 2 is 2-hydroxy-2-propyl, and R 1 is phenyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a 5- to 10-membered heteroaryl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyridyl; R 2 is 2-hydroxy-2-propyl, and R 1 is pyrazolyl; R 2 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 1is S(O2)CH3; R 2 is 2-hydroxy-2-propyl, and R 1 is chloro; R 2 is 2-hydroxy-2-propyl, and R 1 is fluoro; R 2 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 1 is C1-C6 alkyl; R 2 is 1-hydroxy-1-cyclopropyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclobutyl, and R 1 is methyl; R 2 is 1-hydroxy-1-cyclopentyl and R 1 is methyl; R 2 is 1-hydroxy-1-cyclohexyl, and R 1 is methyl; R 2 is morpholinyl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is methyl; R 2 is 1,3-dioxolan-2-yl and R 1 is fluoro; R 2 is 1,3-dioxolan-2-yl and R 1 is chloro; R 2 is C1-C6 alkyl optionally substituted with one or more oxo, and R 1 is methyl; R 2 is (dimethylamino)methyl, and R 1 is methyl; R 2is COCH3 and R 1 is methyl; or R 2 is 2-methoxy-2-propyl, and R 1 is methyl.

[0872] In certain embodiments of the compound of formula AA, The substituted ring A is [ka] and; R 1 and R 2 is one of the following combinations: R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C1-C6 alkyl optionally substituted with one or more hydroxy; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is C6~C 10 is aryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a 5- to 10-membered heteroaryl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is SF5; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is S(O2)C1-C6 alkyl; R 1 is a C1-C6 alkyl optionally substituted with one or more hydroxy; R 2 is a halo; R 1 is a C3-C7 cycloalkyl optionally substituted with one or more hydroxy Yes, R 2 is C1-C6 alkyl; R 1 is a 3- to 7-membered heterocycloalkyl group optionally substituted with one or more hydroxy groups; R 2 i...

Claims

1. A compound selected from the group consisting of: 【Chemistry 1】 (wherein TBS represents tert-butyldimethylsilyl, and Boc represents tert-butyloxycarbonyl.)

2. 2. The compound of claim 1, wherein the compound is: or a pharmaceutically acceptable salt thereof. 【Chemistry 2】

3. 2. The compound of claim 1, wherein the compound is: or a pharmaceutically acceptable salt thereof. 【Transformation 3】

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