Collagen and iron drink
By adding specific plant extracts to compositions containing iron compounds and collagen or elastin peptides, the unpleasant odor is suppressed, improving the palatability and marketability of oral liquid compositions.
Patent Information
- Application Number
- JP2021195865
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2020-11-19
- Filing Date
- 2021-12-02
- Publication Date
- 2026-02-25
- Estimated Expiration
- 2041-09-03
AI Technical Summary
The combination of iron compounds with collagen peptides or elastin peptides in oral liquid compositions results in a characteristic unpleasant odor, making the compositions less palatable and less suitable for daily consumption.
Incorporating specific plant extracts such as lemon balm, Houttuynia cordata, artichoke, or rosemary extracts into the oral liquid composition to suppress the unpleasant odor caused by the interaction of iron compounds with collagen or elastin peptides.
The incorporation of these plant extracts significantly reduces the unpleasant odor, enhancing the palatability and marketability of the compositions, allowing for daily consumption.
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Abstract
Description
[Technical Field]
[0001] The present invention relates to an oral liquid composition containing an iron compound, which can be used in the fields of pharmaceuticals, quasi-drugs, foods, etc. [Background technology]
[0002] Although iron is an essential metal for living organisms, it has been reported that iron intake tends to be insufficient compared to the recommended intake, especially in women. The Dietary Reference Intakes for Japanese (2020 edition) recommends 10.5 mg of iron for women, but the 2018 National Health and Nutrition Survey found that women's iron intake was 7.5 mg, resulting in a daily iron deficiency of approximately 3 mg (Non-Patent Document 1). Drinks and supplements containing iron compounds are used as an efficient dietary intake method, but there is a problem in that the iron compounds react with other ingredients, impairing flavor and quality (Patent Documents 1 and 2).
[0003] In recent years, beverages and supplements containing collagen peptides and elastin peptides have become increasingly popular. Collagen is the main protein that constitutes the dermis, ligaments, tendons, bones, cartilage, etc. (Non-Patent Document 2). Collagen peptides can be obtained by methods such as hydrolyzing collagen obtained from animals or fish. Elastin is the main fibrous protein that is widely distributed in various tissues that require elasticity, such as the ligamentum nuchale, aorta, skin, and lungs (Non-Patent Document 3).
[0004] Elastin peptides are obtained by methods such as hydrolysis of raw materials such as animal aortas and fish bulbus arteriosus. As such, collagen peptides and elastin peptides have a characteristic unpleasant odor because they are obtained from proteins derived from pigs or fish.
[0005] To date, a reported beverage containing collagen hydrolysate and a good flavor is one that contains two or more extracts selected from the group consisting of Job's tears extract, safflower extract, apricot extract, and carrot extract, royal jelly, one or more vitamins selected from vitamin B2 and vitamin B6, dietary fiber, sugars, stevia, plum juice, sodium L-aspartate, an acidulant, and a fruit flavor (Patent Document 3). [Prior art documents] [Non-patent literature]
[0006] [Non-Patent Document 1] Food and Development Vol.55 No.6 P.41 [Non-patent document 2] Hiroki Ohara et al., Japanese Journal of Food Chemical Engineering, Vol. 56, No. 3, P. 137-145 (2009) [Non-patent document 3] Food and Development Vol.50 No.7 P.14 [Patent documents]
[0007] [Patent Document 1] Japanese Patent Application Laid-Open No. 2017-93397 [Patent Document 2] Japanese Patent Application Laid-Open No. 2000-279143 [Patent Document 3] Japanese Patent Application Publication No. 5-199855 Summary of the Invention [Problem to be solved by the invention]
[0008] The present inventors have discovered that when an iron compound is added to an oral liquid composition containing collagen peptide or elastin peptide, the composition enhances a characteristic unpleasant odor. Therefore, an object of the present invention is to provide an oral liquid composition that suppresses this characteristic unpleasant odor and is highly palatable and can be taken daily. [Means for solving the problem]
[0009] As a result of extensive research to solve this problem, we discovered that the incorporation of specific plant extracts can suppress the unpleasant odor that is characteristic of combining iron compounds with collagen peptides or elastin peptides, and thus completed the present invention.
[0010] The present invention has been made based on these findings and has the following aspects. (1)(A) Iron compounds, (B) at least one peptide selected from the group consisting of collagen peptides and elastin peptides; (C) an oral liquid composition comprising at least one plant extract selected from the group consisting of lemon balm extract, Houttuynia cordata extract, artichoke extract, and rosemary extract; (2) The oral liquid composition according to (1), wherein the content of the iron compound (A) is 0.0002 to 0.2 w / v% in terms of iron. (3) (B) The oral liquid composition according to (1) or (2), wherein the content of collagen peptide is 0.02 to 20 w / v%. (4) (B) The oral liquid composition according to any one of (1) to (3), wherein the content of the elastin peptide is 0.0002 to 2 w / v%. (5) The oral liquid composition according to any one of (1) to (4), wherein the content of at least one plant extract selected from the group consisting of lemon balm extract, Houttuynia cordata extract, artichoke extract, and rosemary extract (C) is 0.0002 to 2 w / v%. (6) The oral liquid composition according to any one of (1) to (5), wherein the iron compound is at least one selected from the group consisting of ferrous fumarate, ferric chloride, iron citrate, ammonium iron citrate, sodium ferrous citrate, ferrous gluconate, iron lactate, ferrous pyrophosphate, ferric pyrophosphate, ferrous sulfate, and heme iron. (7) The oral liquid composition according to any one of (1) to (6), having a pH of 2.5 to 4.5. (8) The oral liquid composition according to any one of (1) to (7), wherein the oral liquid composition is a liquid beverage. (9) A method for suppressing an unpleasant odor caused by blending an iron compound with a collagen peptide or an elastin peptide by blending at least one plant extract selected from the group consisting of lemon balm extract, Houttuynia cordata extract, artichoke extract, and rosemary extract. is. [Effects of the Invention]
[0011] According to the present invention, it is possible to provide an oral liquid composition that suppresses the unpleasant odor that is characteristic of a mixture of an iron compound and a collagen peptide or an elastin peptide. DETAILED DESCRIPTION OF THE INVENTION
[0012] In the present invention, the "iron compound" may be either a divalent iron compound or a trivalent iron compound, such as ferrous fumarate, ferric chloride, iron citrate, ammonium ferrous citrate, sodium ferrous citrate, ferrous gluconate, ferrous lactate, ferrous pyrophosphate, ferric pyrophosphate, ferrous sulfate, or heme iron. The higher the iron content, the greater the unpleasant odor when combined with collagen peptides or elastin peptides. The lower limit of the iron content in the oral liquid composition of the present invention, calculated as iron, is preferably 0.0002 w / v%, more preferably 0.001 w / v%, even more preferably 0.002 w / v%, even more preferably 0.006 w / v%, and most preferably 0.01 w / v%. The lower limit of the iron compound is preferably 0.001 w / v%, more preferably 0.005 w / v%, even more preferably 0.01 w / v%, even more preferably 0.02 w / v%, even more preferably 0.03 w / v%, and most preferably 0.05 w / v%. When the collagen peptide of the present invention and lemon balm extract are combined, the lower limit of the iron content in the oral liquid composition of the present invention is preferably 0.006 w / v%, more preferably 0.01 w / v%, and the lower limit of the iron compound is preferably 0.03 w / v%, more preferably 0.05 w / v%. The upper limit of the iron content in the oral liquid composition of the present invention is preferably 0.2 w / v%, more preferably 0.04 w / v%. The upper limit of the iron content is preferably 3.3 w / v%, more preferably 1.2 w / v%.
[0013] In the present invention, the origin of the "collagen peptide" is not particularly limited, and it may be synthetic, or may be collagen peptide produced by extraction from by-products such as skin, bones, ligaments, tendons, and cartilage produced during the processing of livestock such as cows and pigs, or fish; however, collagen peptides derived from pigs and fish are preferred. Collagen peptides obtained by decomposing collagen protein using enzymes or chemical treatments are preferred. The average molecular weight of the collagen peptide is not particularly limited, but is preferably 500 to 50,000, and more preferably 1,000 to 25,000. The content of the collagen peptide in the oral liquid composition of the present invention is preferably 0.02 to 20 w / v%, and more preferably 0.1 to 15 w / v%.
[0014] The collagen peptide of the present invention may be a commercially available product, such as "Nippi Peptide PS-1," "Nippi Peptide PRA-P," and "Nippi Peptide FCP-EX" manufactured by Nippi Corporation, "HACP-CF" and "HACP-TF" manufactured by Jellice Co., Ltd., "Collapep PU," "Collapep JB," "HDL-50SP," and "SCP-3100" manufactured by Nitta Gelatin Co., Ltd., and "peptan P2000HD" manufactured by Rousselot Co., Ltd. The content of the "collagen peptide" of the present invention is preferably 1 to 75,000 parts by mass, more preferably 5 to 7,500 parts by mass, and even more preferably 20 to 2,500 parts by mass, per part by mass of iron, calculated as iron.
[0015] In the present invention, the origin of the "elastin peptide" is not particularly limited, and it may be synthetic or may be produced by hydrolyzing the aorta of an animal or the bulbus arteriosus of a fish using enzymes, but elastin peptides derived from the aorta of a pig or the bulbus arteriosus of a skipjack tuna are preferred. The elastin peptide of the present invention may be commercially available, such as "P-elastin" manufactured by Nippon Meat Packers Ltd., "Katsuo Elastin" manufactured by Hayashikane Sangyo Co., Ltd., and "Bidan Elastin" manufactured by Nippon Suisan Kaisha, Ltd. The molecular weight of the elastin peptide is not particularly limited, but is preferably 100 to 20,000, and more preferably 150 to 10,000.
[0016] The content of the elastin peptide in the oral liquid composition of the present invention is preferably 0.0002 to 2 w / v %, more preferably 0.002 to 1 w / v %.
[0017] The content of the "elastin peptide" of the present invention is preferably 0.1 to 5000 parts by mass, more preferably 0.5 to 500 parts by mass, and even more preferably 0.5 to 100 parts by mass, per part by mass of iron, calculated as iron.
[0018] The lemon balm of the present invention is a herbal medicine or plant derived from the leaves of lemon balm (also known as melissa, scientific name: Melissa officinalis) of the Lamiaceae family, and is used in the form of a herbal medicine powder or plant powder, a herbal medicine extract or a plant extract. The herbal medicine powder or plant powder used in the present invention may be, for example, a dried, shredded product further pulverized into a powder.
[0019] The "lemon balm extract" used in the present invention can be extracted with solvents such as water, lower aliphatic alcohols (methanol, ethanol, isopropyl alcohol, etc.), polyhydric alcohols (1,3-butylene glycol, propylene glycol, dipropylene glycol, glycerin, etc.), lower aliphatic ketones (acetone, etc.), or mixtures of the above solvents, but extraction with water, lower aliphatic alcohols, polyhydric alcohols, or mixtures of these is most preferred. The form of the extract is not particularly limited, and it can be made into a dried extract powder, extract powder, soft extract, liquid extract, etc. by heat treatment, freeze-drying or vacuum drying, powdering with the addition of excipients such as dextrin, etc. Commercially available lemon balm extract products include "Lemon Balm Extract A" and "Lemon Balm Extract Powder MF" from Maruzen Pharmaceutical Co., Ltd., and "Falcorex Melissa B" from Ichimaru Falcos Co., Ltd.
[0020] The content of lemon balm extract in the oral liquid composition of the present invention, as net lemon balm extract excluding excipients, extraction solvents, etc., is preferably 0.0002 w / v% or more, more preferably 0.001 w / v% or more, in terms of the effects of the present invention. From the viewpoint of flavor, the upper limit is preferably 2 w / v%, more preferably 0.5 w / v%, and most preferably 0.25 w / v%. When iron and lemon balm are combined, the content of lemon balm extract is preferably 0.001 parts by mass or more, more preferably 0.005 parts by mass or more, in terms of the effects of the present invention, in iron equivalent. The upper limit is preferably 10,000 parts by mass, more preferably 1,250 parts by mass, and even more preferably 125 parts by mass, in terms of iron equivalent, per part by mass of iron.
[0021] The Houttuynia cordata of the present invention is a herbal medicine or plant derived from the aerial parts of the flowering stage of Houttuynia cordata Thunberg (Saururaceae), which belongs to the family Saururaceae, and is used in the form of a herbal medicine powder or plant powder, a herbal medicine extract or a plant extract. The herbal medicine powder or plant powder used in the present invention may be, for example, a dried, shredded product further pulverized into a powder. The "Houttuynia cordata extract" used in the present invention can be extracted with solvents such as water, lower aliphatic alcohols (e.g., methanol, ethanol, isopropyl alcohol), polyhydric alcohols (e.g., 1,3-butylene glycol, propylene glycol, dipropylene glycol, glycerin), lower aliphatic ketones (e.g., acetone), or mixtures of the above solvents, but extraction with water, lower aliphatic alcohols, polyhydric alcohols, or mixtures of these is most preferred.
[0022] The form of the extract is not particularly limited, and can be made into a dried extract powder, extract powder, soft extract, fluid extract, etc. by heat treatment, freeze-drying or vacuum drying, powdering with the addition of excipients such as dextrin, etc. Commercially available Houttuynia cordata extracts include "Houttuynia Cordata Extract," "Houttuynia Cordata Extract BG," and "Houttuynia Cordata Extract Powder MF" from Maruzen Pharmaceutical Co., Ltd., and "Falcorex Houttuynia Cordata B," "Falcorex Houttuynia Cordata E," "Falcorex Houttuynia Cordata W," and "Houttuynia Cordata DXP100" from Ichimaru Falcos Co., Ltd.
[0023] The content of Houttuynia cordata extract in the oral liquid composition of the present invention, as net Houttuynia cordata extract excluding excipients, extraction solvents, etc., is preferably 0.0002 w / v% or more, more preferably 0.002 w / v% or more, in terms of the effects of the present invention. The upper limit is preferably 2 w / v% and more preferably 0.2 w / v% in terms of flavor. The content of Houttuynia cordata extract, in terms of the effects of the present invention, is preferably 0.001 parts by mass or more, more preferably 0.01 parts by mass or more, and even more preferably 0.05 parts by mass or more, in terms of iron. The upper limit is preferably 10,000 parts by mass, more preferably 1,000 parts by mass, and even more preferably 100 parts by mass, in terms of iron.
[0024] The artichoke of the present invention is a herbal medicine or plant derived from the leaves of Cynara scolymus Linne (Compositae), a member of the Asteraceae family, and is used in the form of a herbal medicine powder or plant powder, a herbal medicine extract, or a plant extract. The herbal medicine powder or plant powder used in the present invention may be, for example, a dried, chopped product that is further finely pulverized into a powder. The "artichoke extract" used in the present invention can be extracted with a solvent such as water, a lower aliphatic alcohol (e.g., methanol, ethanol, isopropyl alcohol), a polyhydric alcohol (e.g., 1,3-butylene glycol, propylene glycol, dipropylene glycol, glycerin), a lower aliphatic ketone (e.g., acetone), or a mixture of these solvents. Of these, extraction with water, a lower aliphatic alcohol, a polyhydric alcohol, or a mixture of these is most preferred. The form of the extract is not particularly limited, and it can be made into a dried extract powder, extract powder, soft extract, liquid extract, etc. by heat treatment, freeze-drying or vacuum drying, powdering with the addition of excipients such as dextrin, etc. Commercially available artichoke extract products include "Biobenefity (registered trademark)," "Biobenefity G," "Biobenefity HS," "Cinaropicrin F," and "Biobenefity F" manufactured by Ichimaru Falcos Co., Ltd.
[0025] The content of artichoke extract in the oral liquid composition of the present invention, as net artichoke extract excluding excipients, extraction solvents, etc., is preferably 0.0002 w / v% or more, more preferably 0.0006 w / v% or more, in terms of the effects of the present invention. From the viewpoint of flavor, the upper limit is preferably 2 w / v%, more preferably 0.06 w / v%. From the viewpoint of the effects of the present invention, the content of artichoke extract is preferably 0.001 parts by mass or more, more preferably 0.003 parts by mass or more, and even more preferably 0.015 parts by mass or more, in terms of iron. The upper limit is preferably 10,000 parts by mass, more preferably 300 parts by mass, and even more preferably 30 parts by mass, in terms of iron.
[0026] The rosemary of the present invention is a herbal medicine or plant derived from the leaves of rosemary (scientific name: Rosmarinus Officinalis), a plant of the Labiatae family, and is used in the form of a herbal medicine powder or plant powder, or a herbal medicine extract or plant extract. The herbal medicine powder or plant powder used in the present invention may be, for example, a dried, powdered product obtained by further finely grinding a dried, chopped product. The "rosemary extract" used in the present invention can be extracted with a solvent such as water, a lower aliphatic alcohol (e.g., methanol, ethanol, isopropyl alcohol), a polyhydric alcohol (e.g., 1,3-butylene glycol, propylene glycol, dipropylene glycol, glycerin), or a lower aliphatic ketone (e.g., acetone), or a mixture of these solvents. Extraction with water, a lower aliphatic alcohol, a polyhydric alcohol, or a mixture of these is most preferred. The form of the extract is not particularly limited, and can be made into a dried extract powder, extract powder, soft extract, or liquid extract by heat treatment, freeze-drying or vacuum drying, or powdering with an excipient such as dextrin. Commercially available rosemary extracts are also used in the present invention. Commercially available extract powders may also be used, including "Rosemary Extract (Bioactives Japan)" and "Rosemary Extract MF (Maruzen Pharmaceuticals)."
[0027] The content of rosemary extract in the oral liquid composition of the present invention, as net rosemary extract excluding excipients, extraction solvents, etc., is preferably 0.0002 w / v% or more, more preferably 0.0008 w / v% or more, in terms of the effects of the present invention. The upper limit is preferably 2 w / v% and more preferably 0.1 w / v% in terms of flavor. The content of rosemary extract, in terms of the effects of the present invention, is preferably 0.001 parts by mass or more, more preferably 0.004 parts by mass or more, and even more preferably 0.02 parts by mass or more, per part by mass of iron, in terms of iron. The upper limit is preferably 10,000 parts by mass, more preferably 500 parts by mass, and even more preferably 50 parts by mass, per part by mass of iron, in terms of iron.
[0028] The present invention can significantly suppress the unpleasant odor that occurs when an iron compound is combined with a collagen peptide or an elastin peptide by combining a specific plant extract, namely, lemon balm extract, Houttuynia cordata extract, artichoke extract, or rosemary extract.
[0029] The oral liquid composition of the present invention is not particularly limited as long as it is a liquid that can be taken orally, and examples thereof include pharmaceuticals, quasi-drugs, and foods (including not only general foods but also nutritionally functional foods, foods for specified health uses, and foods with functional claims).
[0030] Examples of pharmaceuticals and quasi-drugs include oral liquid preparations, energy drinks, etc. Examples of foods include soft drinks, carbonated drinks, sports and functional drinks, non-alcoholic drinks, milk drinks, tea drinks, coffee drinks, fruit and vegetable drinks, jelly drinks, etc. More preferred are pharmaceuticals and quasi-drugs such as oral liquid preparations and energy drinks, and more preferred are foods such as nutritional functional foods and foods for specified health uses, carbonated drinks, and jelly drinks.
[0031] The pH of the oral liquid composition of the present invention is not particularly limited, but is preferably 2.5 to 4.5, more preferably 3.0 to 4.0, from the viewpoint of palatability. In order to maintain the pH within the above range, a pH adjuster such as an organic acid can be added as needed.
[0032] The oral liquid composition of the present invention can be produced by a conventional method, and the method is not particularly limited. Usually, each ingredient is weighed out, dissolved in an appropriate amount of purified water, stirred, and then the pH is adjusted. The volume is adjusted by adding purified water, and filtering and sterilizing the solution as necessary. Obtained.
[0033] The oral liquid composition of the present invention may further contain other ingredients such as vitamins, minerals, amino acids and their salts, herbal medicines, herbal extracts, caffeine, royal jelly, dextrin, etc., as appropriate, provided that the effects of the present invention are not impaired. Furthermore, if necessary, additives such as antioxidants, colorants, flavorings, corrigents, preservatives, sweeteners, and acidulants may also be added as appropriate, provided that the effects of the present invention are not impaired. [Example]
[0034] The present invention will be described in more detail below with reference to examples and comparative examples.
[0035] (Comparative Examples 1-1 to 18, Examples 1-1 to 18) Oral liquid compositions were prepared according to the formulations shown in Tables 1 to 10 and the following method. First, collagen peptide (porcine-derived: Collapep JB manufactured by Nitta Gelatin Co., Ltd., Nippi Peptide PRA-P manufactured by Nippi Co., Ltd., fish-derived: Nippi Peptide FCP-EX manufactured by Nippi Co., Ltd.) or elastin peptide (fish-derived: Bonito Elastin manufactured by Hayashikane Sangyo Co., Ltd., pig-derived: P-elastin manufactured by Nippon Meat Packers Co., Ltd.), citric acid, and sodium benzoate were added to approximately 60% of the total volume of purified water, and the mixture was thoroughly stirred. Ferrous ammonium citrate was then added, and purified water was added to approximately 80% of the total volume, followed by thorough stirring. Next, lemon balm extract (hot water extract, Lemon Balm Extract Powder MF, manufactured by Maruzen Pharmaceutical Co., Ltd.), Houttuynia cordata extract (water extract, Houttuynia cordata Extract Powder, manufactured by Nippon Funa Yakuhin Co., Ltd.), artichoke extract (ethanol extract, BioBenefit F, manufactured by Ichimaru Pharcos Co., Ltd.), or rosemary extract (hot water extract, Rosemary Extract MF, manufactured by Maruzen Pharmaceutical Co., Ltd.) was added as a plant extract and thoroughly stirred. After that, the pH was adjusted using hydrochloric acid or sodium hydroxide, and purified water was added to the total volume to obtain oral liquid compositions (Examples 1-1 to 18). 50 ml of these oral liquid compositions were filled into screw tubes No. 7 (manufactured by Maruemu Co., Ltd.) and sterilized at 80°C for 25 minutes. Oral liquid compositions without added plant extracts served as controls (Comparative Examples 1 to 18). The oral liquid compositions prepared as described above were stored at 65°C for 7 days, smelled, and evaluated for the degree of reduction in unpleasant odor according to the criteria in Table 11. The amount of each extract in Tables 1 to 10 is the net amount of extract excluding the excipients and extraction solvent contained in the raw material extract.
[0036] [Table 1]
[0037] [Table 2]
[0038] [Table 3]
[0039] [Table 4]
[0040] [Table 5]
[0041] [Table 6]
[0042] [Table 7]
[0043] [Table 8]
[0044] [Table 9]
[0045] [Table 10]
[0046] [Table 11]
[0047] As shown in Tables 1 to 6, the incorporation of iron compounds and collagen peptides resulted in the generation of an unpleasant odor (Comparative Examples 1 to 10). As the concentration of collagen peptide increased, the rate of unpleasant odor also increased (Comparative Examples 1 to 3). Furthermore, as the concentration of iron increased, the rate of unpleasant odor also increased (Comparative Examples 2, 4, 5, and 7). On the other hand, the rate of unpleasant odor was reduced by incorporating lemon balm extract, Houttuynia cordata extract, artichoke extract, or rosemary extract (Examples 1-1 to 10-3). As shown in Tables 7 to 10, even when iron compounds and elastin peptides were added, an unpleasant odor occurred (Comparative Examples 11 to 18). The rate of unpleasant odor increased as the concentration of elastin peptide increased (Comparative Examples 12, 14, and 15). Furthermore, the rate of unpleasant odor increased as the concentration of iron increased (Comparative Examples 12 and 13). On the other hand, the rate of unpleasant odor was reduced by adding lemon balm extract, Houttuynia cordata extract, artichoke extract, or rosemary extract (Examples 11-1 to 18). [Industrial Applicability]
[0048] The present invention makes it possible to suppress unpleasant odors that occur when an iron compound and a collagen peptide or an elastin peptide are blended in an oral liquid composition, and is therefore expected to provide oral liquid compositions containing iron compounds and collagen peptides or elastin peptides that are highly marketable in the fields of pharmaceuticals, quasi-drugs, and food.
Claims
1. (A) an iron compound, (B) Collagen peptide An oral liquid composition having a pH of 2.5 to 4.5, characterized by containing (C) Houttuynia cordata extract, wherein the content of (B) collagen peptide is 20 to 2500 parts by mass, calculated as iron, per 1 part by mass of iron, and the content of (C) Houttuynia cordata extract is 0.05 to 100 parts by mass, calculated as iron, per 1 part by mass of iron.
2. 2. The oral liquid composition according to claim 1, wherein the content of the iron compound (A) is 0.0002 to 0.2 w / v % in terms of iron.
3. 3. The oral liquid composition according to claim 1, wherein the content of (B) collagen peptide is 0.02 to 20 w / v %.
4. 4. The oral liquid composition according to claim 1, wherein the content of (C) Houttuynia cordata extract is 0.0002 to 2 w / v %.
5. 5. The oral liquid composition according to claim 1, wherein the iron compound is at least one selected from the group consisting of ferrous fumarate, ferric chloride, iron citrate, ammonium ferrous citrate, sodium ferrous citrate, ferrous gluconate, iron lactate, ferrous pyrophosphate, ferric pyrophosphate, ferrous sulfate, and heme iron.
6. 6. The oral liquid composition according to claim 1, which is a liquid beverage.
7. A method for suppressing an unpleasant odor caused by combining the collagen peptide with the iron compound in an oral liquid composition having a pH of 2.5 to 4.5, the oral liquid composition containing an iron compound and collagen peptide, and having a collagen peptide content of 20 to 2,500 parts by mass, in iron equivalent, per 1 part by mass of iron, by combining 0.05 to 100 parts by mass, in iron equivalent, of Houttuynia cordata extract with per 1 part by mass of iron.
Citation Information
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