Composition

Abstract

To suppress crystal deposition in a composition comprising niacinamide and tranexamic acid.SOLUTION: There is provided a composition which comprises the following components (A) to (C): (A) niacinamide, (B) tranexamic acid and (C) pyrrolidone carboxylic acid or a salt thereof.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a composition. [Background technology]

[0002] Maintaining healthy, beautiful skin is a major concern for many people. Skin can develop a variety of problems, including roughness, wrinkles, sagging, and pigmentation, due to various factors such as ultraviolet rays, dryness, aging, and stress. In order to improve these skin problems from multiple angles, it is thought that applying multiple ingredients with different effects to the skin would be effective.

[0003] For example, niacinamide is a type of vitamin that has skin effects such as wrinkle reduction, improvement of skin barrier function, whitening, and skin texture improvement (see, for example, Non-Patent Document 1). Tranexamic acid has anti-inflammatory properties and is used as an active ingredient in pharmaceuticals, and is also known to have melanin production inhibitory effects (see, for example, Patent Document 1). A composition containing these two ingredients, which have different actions, is expected to provide multifaceted effects for multiple skin problems.

[0004] On the other hand, it is known that compositions containing niacinamide or tranexamic acid alone precipitate crystals over time. Regarding tranexamic acid, it is known that a topical skin preparation containing 0.1 to 5% by mass of tranexamic acid, 0.01 to 5% by mass of a long-chain acylsulfonate-type anionic surfactant, and a higher alcohol, and having a pH adjusted to 3 to 6, prevents the precipitation of tranexamic acid crystals (see, for example, Patent Document 2). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2008-100933 [Patent Document 2] Japanese Patent Application Laid-Open No. 2011-084551 [Non-patent literature]

[0006] [Non-Patent Document 1] Cosmeceuticals and Cosmetic practice Chap.10.2014 page 103-112 Summary of the Invention [Problem to be solved by the invention]

[0007] In the past, compositions containing high concentrations of niacinamide or tranexamic acid have had significant crystal precipitation problems, and when the composition adheres to the discharge part or lid of the container during use, crystal precipitation occurs.However, no research has been conducted on the suppression of crystal precipitation in compositions containing two components, niacinamide and tranexamic acid.The present invention has found that the degree of crystal precipitation in compositions containing niacinamide and tranexamic acid is more severe than that occurring when each component is present alone, and aims to solve this problem. [Means for solving the problem]

[0008] In order to solve this problem, the present inventors conducted extensive research and found that the inclusion of pyrrolidonecarboxylic acid or a salt thereof in a formulation containing niacinamide and tranexamic acid exerts an inhibitory effect on crystal precipitation.

[0009] That is, the present invention provides the following components (A) to (C): (A) Niacinamide (B) Tranexamic acid (C) Pyrrolidonecarboxylic acid or its salt The present invention relates to a composition comprising: [Effects of the Invention]

[0010] According to the present invention, it is possible to provide a composition that inhibits crystallization in a composition containing niacinamide and tranexamic acid, a crystallization inhibitor, and a cosmetic or topical skin preparation. DETAILED DESCRIPTION OF THE INVENTION

[0011] The present invention will be described in detail below. In this specification, the symbol "to" means a range including the numerical values ​​before and after it.

[0012] Ingredient (A): Niacinamide Niacinamide, component (A) of the present invention, is an amide of nicotinic acid (vitamin B3 / niacin). Niacinamide is a water-soluble vitamin and a known substance that is a member of the B vitamin family. It can be extracted from natural products (such as rice bran) or synthesized by known methods. Specifically, niacinamide listed in the 15th edition of the Japanese Pharmacopoeia (2008) can be used.

[0013] The content of component (A) in the present invention is not particularly limited, but from the viewpoint of the crystal precipitation suppression effect, it is preferably 1 to 10 mass % (hereinafter simply abbreviated as "%"), more preferably 3 to 8%, and even more preferably 4 to 7%.

[0014] Ingredient (B): Tranexamic acid Tranexamic acid, component (B) used in the present invention, is a type of amino acid represented by trans-4-(aminomethyl)cyclohexane-1-carboxylic acid. Tranexamic acid is sometimes used for its skin whitening and anti-inflammatory effects, and is also used as a hemostatic agent.

[0015] In the present invention, the content of component (B) is not particularly limited, but from the viewpoint of the crystal precipitation suppression effect, it is preferably 1 to 7%, more preferably 1.3 to 6%, and even more preferably 1.5 to 5%.

[0016] Component (C): Pyrrolidonecarboxylic acid or its salt The structural formula of pyrrolidone carboxylic acid in the component (C) used in the present invention, pyrrolidone carboxylic acid or a salt thereof, is shown in the following formula (1). [ka]

[0017] Pyrrolidone carboxylic acid can be produced by dehydrating glutamic acid extracted from seaweed, wheat flour, or sugarcane. The sodium salt of pyrrolidone carboxylic acid is called PCA sodium. PCA sodium improves oxidative stability and increases stability. It is also a component of NMF (natural moisturizing factor), a substance that retains moisture in the stratum corneum of the skin.

[0018] Examples of inorganic base salts of pyrrolidonecarboxylic acid include monovalent to trivalent inorganic base salts of pyrrolidonecarboxylic acid. Examples of monovalent to trivalent inorganic base salts include alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt and magnesium salt; and metal salts such as copper salt, zinc salt, and aluminum salt. Among these, sodium salt, potassium salt, calcium salt, magnesium salt, and aluminum salt are preferred, and sodium salt and potassium salt are more preferred.

[0019] The method for producing pyrrolidone carboxylic acid or its inorganic base salt is not particularly limited. For example, an inorganic base salt of pyrrolidone carboxylic acid may be produced by dehydrating glutamic acid extracted from organisms such as seaweed or sugarcane, or from processed products such as wheat flour, to obtain pyrrolidone carboxylic acid, which is then neutralized with a base containing a metal ion (e.g., sodium ion). Commercially available pyrrolidone carboxylic acid or its inorganic base salt may be used. Examples include AJIDEW A-100 (manufactured by Ajinomoto Co., Inc.), and sodium pyrrolidone carboxylic acid such as AJIDEW-N-50 and AJIDEW-NL-50 (both manufactured by Ajinomoto Co., Inc.).

[0020] In the present invention, the content of component (C) is not particularly limited, but from the viewpoint of the crystal precipitation suppression effect, it is preferably 0.0005 to 1%, and more preferably 0.001 to 0.5%.

[0021] In the present invention, the composition can be obtained by appropriately containing the components (A) to (C), but specifying the mass ratio of the components (A) to (C) is preferable because it provides a superior effect of inhibiting crystal precipitation. This mass ratio is not particularly limited, and the mass ratio (A) / (B) of the components (A) to (B) is preferably 0.2 or more, more preferably 0.6 or more, even more preferably 1.2 or more, and particularly preferably 2 or more. It is also preferably 5 or less, more preferably 4 or less, and even more preferably 3 or less.

[0022] In the present invention, the composition can be obtained by appropriately containing the components (A) to (C), but specifying the mass ratio of the components (A) to (C) is preferable because it provides a superior effect in inhibiting crystal precipitation. This mass ratio is not particularly limited, and the mass ratio (A) / (C) of the components (A) to (C) is preferably 2 or more, more preferably 4 or more, and even more preferably 8 or more. It is also preferably 2000 or less, more preferably 1000 or less, even more preferably 800 or less, and particularly preferably 100 or less.

[0023] In the present invention, the composition can be obtained by appropriately incorporating the components (A) to (C), but specifying the mass ratio of the components (A) to (C) is preferable because it provides a superior effect in inhibiting crystal precipitation. This mass ratio is not particularly limited, and the mass ratio (B) / (C) of the components (B) to (C) is preferably 1 or greater, more preferably 1.5 or greater, and even more preferably 3 or greater. It is also preferably 4000 or less, more preferably 1100 or less, even more preferably 500 or less, and particularly preferably 100 or less.

[0024] In the present invention, the composition can be obtained by appropriately containing the components (A) to (C), but specifying the mass ratios of the components (A) to (C) is preferred because it provides a superior effect in inhibiting crystal precipitation. Such mass ratios are not particularly limited, and the mass ratio of the total amount of components (A) and (B) to the amount of component (C), [(A) + (B)] / (C), is preferably 5 or more, more preferably 10 or more. Furthermore, it is preferably 10,000 or less, more preferably 5,000 or less, even more preferably 2,000 or less, and even more preferably 1,500 or less.

[0025] The present invention can further contain a phosphate salt as component (D). The salt may be an organic salt, an inorganic salt, or the like, but is not particularly limited thereto. From the viewpoint of adjusting the pH of the composition and exerting a buffering effect, an inorganic salt is preferred, and a sodium salt is particularly preferred. By including a phosphate salt in the composition of the present invention, it is expected that the phosphate salt will be stable in a composition containing both components (A) and (B). The phosphate salt as component (D) of the present invention may be used alone or in combination of two or more thereof. For example, sodium monohydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, etc. are preferably used. Among these, one or more selected from the group consisting of sodium monohydrogen phosphate and sodium dihydrogen phosphate are preferred, and sodium monohydrogen phosphate and sodium dihydrogen phosphate are more preferred.

[0026] The content of component (D) in the present invention is not particularly limited, but is preferably 0.01% or more, more preferably 0.05% or more, and even more preferably 0.1% or more in the composition. It is also preferably 1% or less, more preferably 0.5% or less, and even more preferably 0.3% or less. This range is more preferable because it provides a more excellent crystal precipitation suppression effect.

[0027] The present invention may further contain a sugar alcohol as component (E). The addition of a sugar alcohol in the present invention is more preferable because it provides a superior effect of inhibiting crystal precipitation. The sugar alcohol used in the present invention is not particularly limited, and any can be used. Examples include erythritol, sorbitol, mannitol, maltitol, xylitol, galactitol, arabitol, trehalose, and pentaerythritol, and one or more of these can be used in combination. Among these, one or more selected from the group consisting of erythritol, sorbitol, mannitol, and maltitol are preferred, one or more selected from the group consisting of erythritol, sorbitol, and maltitol are more preferred, and one or more selected from the group consisting of erythritol and sorbitol are even more preferred.

[0028] In the present invention, the content of component (E) in the composition is not particularly limited, but is preferably 0.1% or more, more preferably 0.2% or more, and even more preferably 0.3% or more. Also, it is preferably 5% or less, more preferably 3% or less, and even more preferably 2% or less. This range is more preferable because it provides a more excellent crystal precipitation suppression effect.

[0029] Furthermore, to the composition of the present invention containing components (A) to (E), components typically used in various preparations, such as cosmetics, quasi-drugs, and topical skin preparations, including pharmaceuticals, can be added as needed, provided that the effects of the present technology are not impaired. Examples of such components include water, oils, surfactants, metal soaps, gelling agents, powders, alcohols, water-soluble polymers, film-forming agents, resins, UV protection agents, inclusion compounds, antibacterial agents, fragrances, deodorants, pH adjusters, cooling agents, animal and microbial extracts, plant extracts, blood circulation promoters, astringents, antiseborrheic agents, whitening agents, anti-inflammatory agents, active oxygen scavengers, cell activators, moisturizers, chelating agents, keratolytic agents, enzymes, hormones, and vitamins. One or more of these may be appropriately selected and used.

[0030] The present invention is not particularly limited as long as it can contain water and can be used in various preparations such as cosmetics, quasi-drugs, and topical skin preparations such as pharmaceuticals. The water may be purified water, hot spring water, deep sea water, or steam-distilled water from plants, and one or more types may be appropriately selected and used as needed. The water content is not particularly limited, but is preferably 10 to 99%, and more preferably 20 to 95%.

[0031] The composition of the present invention containing components (A) to (E) can be obtained by a known method, but is not particularly limited to this method. For example, the composition can be obtained by dissolving components (A), (B), and (D) in water, and then adding and mixing components (C) and (E).

[0032] The composition of the present invention is not particularly limited, but is preferably a cosmetic or topical skin preparation. Specific examples of the cosmetic and topical skin preparation include basic cosmetics such as emulsions, creams, lotions, serums, packs, all-in-one gels, sunscreens, and cleansers; makeup cosmetics such as makeup bases, BB creams, foundations, blushes, and lipsticks; hair cosmetics such as hair care products, hair tonics, shampoos, and rinses; dispersions, ointments, solutions, aerosols, patches, poultices, and liniments. The cosmetic or topical skin preparation is preferably used on the skin and is expected to have whitening or emollient effects.

[0033] The composition of the present invention containing components (A) to (E) is not particularly limited, but is preferably a crystal precipitation inhibitor. The crystal precipitation inhibitor can be used in cosmetics; topical skin preparations such as quasi-drugs and pharmaceuticals; oral preparations, injections, etc., and is particularly suitable for use in cosmetics and topical skin preparations that are applied to the skin. [Example]

[0034] The present invention will be described in more detail below with reference to examples, but the present invention is not limited thereto in any way.

[0035] Examples 1 to 12 and Comparative Example 1: Lotion Lotions were prepared according to the formulations shown in Tables 1 and 2 below. The crystal precipitation inhibitory effect of each sample (Examples 1 to 12, Comparative Example 1) was evaluated by the following method. The results are also shown in Table 2.

[0036] (Evaluation items) B. Crystal precipitation suppression effect

[0037] [A. Evaluation of crystal precipitation suppression effect] <Evaluation method> To evaluate the crystal precipitation suppression effect, 3 g of each sample (Examples 1 to 12, Comparative Example 1, Reference Examples 1 to 12) was applied to a 3 cm diameter dish (material: polystyrene, manufactured by Corning Incorporated), and the height of the precipitated crystals in each sample (Examples 1 to 12, Comparative Example 1, Reference Examples 1 to 12) after air drying at room temperature for 3 days was measured, and the improvement rate of Example X or Comparative Example X was calculated using the following formula (2), and evaluation was performed according to the following evaluation criteria.

[0038] Improvement rate (%) in Example X or Comparative Example X=100×[(height of precipitated crystals in Reference Example X)−(height of precipitated crystals in Example X or Comparative Example X)] / (height of precipitated crystals in Reference Example X) (2) Here, X represents the number of the example, comparative example or reference example.

[0039] <Judgment criteria> (Judgment): (Evaluation) ◎: Improvement rate is 45% or more ○: Improvement rate is 30% or more but less than 45% ×: Improvement rate is less than 30%

[0040] [Table 1] [Table 2]

[0041] (Manufacturing method) A: Components 1 to 10 were uniformly dissolved and mixed at 60°C, and then cooled to room temperature to obtain a lotion.

[0042] As is clear from the results in Table 2, the lotions of Examples 1 to 12 were excellent in the crystal precipitation inhibitory effect. On the other hand, Comparative Example 1, which did not contain component (C), was not excellent in the crystal precipitation inhibitory effect.

[0043] Example 13: Oil-in-water emulsion (Component) (%) 1.1,3-Butylene glycol 12.0 2. Tranexamic acid 3.0 3. Remaining purified water 4. Niacinamide 4.0 5. Polyethylene glycol monostearate (40E.O.) 0.5 6. Sorbitan sesquioleate 0.1 7. Hydrogenated lecithin 0.1 8. Cholesteryl hydroxystearate (Note 1) 3.0 9. Vaseline 2.0 10. α-olefin oligomer 5.0 11. Shea Butter 2.0 12. Dimethylpolysiloxane (10CS) 1.0 13. Ceramide 3 0.1 14. Astaxanthin 0.1 15. Tocopherol 0.01 16. Cetostearyl Alcohol 2.0 17. Behenyl Alcohol 1.0 18. Methyl parahydroxybenzoate 0.1 19. Acrylic acid-alkyl methacrylate copolymer (Note 2) 0.1 20. Xanthan gum 0.1 21. Sodium hydroxide 0.03 22.Fragrance 0.2 23. Sodium pyrrolidone carboxylate 0.05 Note 1) Salakos HS (manufactured by Nisshin Oillio Co., Ltd.) Note 2) Carbopol ULTREZ21 (manufactured by LUBRIZOL)

[0044] (Manufacturing method) A: Dissolve and mix ingredients 1 to 4 uniformly at 70°C. B: Components 5 to 17 are uniformly dissolved and mixed at 80°C. C: Add B to A and emulsify at 70°C. D: Components 18 to 23 were added to C and mixed, then cooled to 40°C to obtain an oil-in-water emulsion.

[0045] The oil-in-water emulsion of Example 13 was excellent in the crystal precipitation suppression effect.

[0046] Example 14: Oil-in-water emulsion serum (Component) (%) 1.1,3-Butylene Glycol 5.0 2. Tranexamic acid 5.0 3. Tripropylene Glycol 3.0 4. Remaining purified water 5. Niacinamide 3.0 6. Polyoxyethylene sorbitan monooleate (20E.O.) 0.1 7. Polyethylene glycol monostearate (55E.O.) 0.25 8. Macadamia nut oil fatty acid phytosteryl (Note 3) 2.0 9. Light liquid isoparaffin (Note 4) 3.0 10. Dimethylpolysiloxane (6CS) 3.0 11. Cholesterol 0.1 12. Tocopherol 0.01 13. Cetostearyl alcohol 0.5 14. Methyl parahydroxybenzoate 0.1 15. Carbomer 0.15 16. (Sodium acrylate / sodium acryloyldimethyltaurate) copolymer (Note 5) 0.1 17. Sodium hydroxide 0.05 18. Ethanol 5.0 19. Collagen 0.1 20. Elastin 0.1 21. Hyaluronic Acid 0.1 22.Fragrance 0.05 23. Sodium pyrrolidone carboxylate 0.1 Note 3) PLANDOOL-MAS (manufactured by Nippon Fine Chemicals Co., Ltd.) Note 4) Chloratum LES (manufactured by Croda) *5) SIMULGEL EG (SEPIC)

[0047] (Manufacturing method) A: Dissolve and mix ingredients 1 to 4 uniformly at 70°C. B: Components 5 to 12 are uniformly dissolved and mixed at 80°C. C: Add B to A and emulsify at 70°C. D: Components 13 to 23 were added to C and mixed, then cooled to 40°C to obtain an oil-in-water emulsion serum.

[0048] The oil-in-water emulsion cosmetic serum of Example 14 was excellent in the effect of inhibiting crystal precipitation.

[0049] Example 15: Liquid hair serum (Component) (%) 1. Oleic acid 0.15 2. Ethyl oleate 0.2 3. Tocopherol acetate 0.02 4.Menthol 0.5 5. Methyl parahydroxybenzoate 0.1 6. Vinyl acetate-vinylpyrrolidone copolymer (Note 6) 0.1 7.Fragrance 0.2 8. Polyoxyethylene (20E.O.) hydrogenated castor oil 0.3 9. Ethanol 50.0 10. Alkyl-modified carboxyvinyl polymer 0.1 11. Carboxyvinyl polymer 0.1 12. 2-amino-2-methylpropanol 0.05 13. Niacinamide 7.0 14. Tranexamic acid 3.0 15. Remaining purified water 16. Pyrrolidone carboxylic acid 0.008 Note 6) Acorn KS (Osaka Organic Chemical Industry Co., Ltd.)

[0050] (Manufacturing method) A: Mix ingredients 1 to 9. B: Mix ingredients 10 to 15. A was added to CB and mixed to obtain a liquid hair beauty serum.

[0051] The liquid hair serum obtained in Example 15 was excellent in the effect of inhibiting crystal precipitation.

[0052] Example 16: Sheet-type pack cosmetic (Component) (%) 1. Isostearic acid 0.05 2. Polyoxyethylene (60E.O.) hydrogenated castor oil 0.3 3. 2-Ethylhexyl methoxycinnamate 0.05 4. Glycerin 3.0 5.1,3-Butylene Glycol 5.0 6. Ethanol 8.0 7. Sodium citrate 0.02 8. Citric acid 0.05 9. Dipotassium glycyrrhizinate 0.1 10. Phenoxyethanol 0.05 11. Niacinamide 4.0 12. Tranexamic acid 5.0 13. Diethylenetriaminepentaacetic acid pentasodium 40% aqueous solution 0.15 14. Remaining purified water 15. Pyrrolidone carboxylic acid 0.5

[0053] (Manufacturing method) A: Mix 1 to 6 and dissolve. B: Mix 7 to 15 and dissolve. C: Add A to B and mix. D: C was impregnated into a nonwoven fabric to obtain a sheet-type pack cosmetic.

[0054] The sheet-type pack cosmetic of Example 16 was excellent in the crystal precipitation inhibiting effect.

[0055] Example 17: Ointment (Component) (%) 1. Triethanolamine 2.0 2. Glycerin 8.0 3. Remaining purified water 4. Niacinamide 3.0 5. Tranexamic acid 4.0 6. Pyrrolidone carboxylic acid 0.03 7. Dipropylene glycol 1.0 8. Cetyl alcohol 4.0 9. Vaseline 30.0 10. Tocopherol 0.01 11. Stearic acid 18.0 12. Sorbitan Sesquioleate 1.5

[0056] (Manufacturing method) A. Dissolve ingredients (8) to (12) uniformly at 75°C. B. Dissolve ingredients (1) to (7) uniformly at 75°C. B was gradually added to CA, emulsified at 75°C, and cooled to room temperature to obtain an ointment.

[0057] The ointment of Example 17 was excellent in the effect of inhibiting crystal precipitation.

[0058] Example 18: Foundation (Component) (%) 1. PEG-9 Polydimethylsiloxyethyl Dimethicone 1.2 2. Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 0.5 3. Isododecane 25.0 4. (PEG-15 / Lauryl Dimethicone) Crosspolymer 0.1 5. Isotridecyl isononanoate 6.0 6. Trifluoroalkyldimethylsiloxysilicate 2.0 7. Dimer polysiloxane (25°C kinematic viscosity 20CS) 0.5 8. Ethylhexyl methoxycinnamate 5.0 9. Dextrin palmitate 0.1 10. Titanium dioxide treated with 3% triethoxycaprylylsilane (Average particle size 30nm) 6.0 11. 3% Isopropyl Titanium Triisostearate Treated Titanium Oxide (Average particle size 250nm) 7.0 12. Disodium Stearoyl Glutamate 2% Red Iron Oxide 0.6 13. Dimethylpolysiloxane 2% treated yellow iron oxide 1.2 14. Palmitic acid dextrin 2% treated black iron oxide 0.4 15. Distearyldimonium Hectorite 1.0 16. Stearalkonium Hectorite 1.0 17. Silica (spherical non-porous, average particle size 10 μm) 0.5 18. Remaining purified water 19. Bismethoxy PEG-13 (PEG-438 / PPG-110 / SMDI copolymer 0.05 20. Ethanol 8.0 21. 1,3-butylene glycol 0.1 22. Sodium monohydrogen phosphate 0.01 23. Sodium dihydrogen phosphate 0.01 24. Sorbitol 0.2 25. Maltitol 0.4 26. Sodium chloride 0.3 27. Niacinamide 2.0 28. Tranexamic acid 6.0 29. Pyrrolidone carboxylic acid 0.2 30. Tremella fuciformis polysaccharide 3.0

[0059] (Manufacturing method) A. Mix ingredients (1) to (9) uniformly at 80°C. Components (10) to (17) are added to BA and mixed uniformly at room temperature. C. Mix ingredients (18) to (30) uniformly at 60°C. Gradually add C to DB and emulsify at room temperature. The ED was filled into a dispenser container to obtain a foundation.

[0060] The foundation of Example 18 was excellent in the crystal precipitation suppression effect.

[0061] Example 19: Sunscreen (water-in-oil emulsion) (Component) (%) 1. Stearic acid / aluminum hydroxide treated fine particle titanium dioxide 5.0 2. Hydrogen Dimethicone Treated Fine Zinc Oxide 15.0 3. Polyhydroxystearic acid 2.0 4. Isononyl isononanoate 10.0 5. Isopropyl palmitate 8.0 6. PEG-30 Dipolyhydroxystearate 1.0 7. PEG-9 Dimethicone 2.0 8. Cyclopentasiloxane 10.0 9. Remaining purified water 10. Niacinamide 4.5 11. Tranexamic acid 3.0 12. 1,3-Butylene Glycol 3.0 13. Glycerin 4.0 14. Sodium Hyaluronate 1.0 15. Pyrrolidone carboxylic acid 0.15

[0062] (Manufacturing method) A: Components (1) to (4) are mixed and dispersed using a roll mill at 25°C. B: Mix components (5) to (8), add A, and mix and disperse at 25°C. C: Components (9) to (15) were mixed uniformly, added to B, and emulsified at 25°C to obtain a sunscreen (water-in-oil emulsion).

[0063] The sunscreen of Example 19 (water-in-oil emulsion) was excellent in the crystal precipitation inhibitory effect. [Industrial Applicability]

[0064] The present invention can be applied to cosmetics, quasi-drugs, external skin preparations, etc.

Claims

1. The following components (A) to (E): (A) Niacinamide (B) Tranexamic acid (C) Pyrrolidonecarboxylic acid or its salt (D) one or more phosphates selected from the group consisting of sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate (E) one or more sugar alcohols selected from the group consisting of erythritol, sorbitol, and maltitol A composition comprising:

2. 2. The composition according to claim 1, wherein the mass ratio (A) / (B) of the component (A) to the component (B) is 0.2 to 5.

3. 3. The composition according to claim 1, wherein the mass ratio (A) / (C) of the component (A) to the component (C) is 2 to 2,000.

4. The composition according to any one of claims 1 to 3, wherein the mass ratio (B) / (C) of the component (B) to the component (C) is 1 to 4,000.

5. The composition according to any one of claims 1 to 4, wherein the mass ratio of the total amount of components (A) and (B) to component (C), [(A) + (B)] / (C), is 5 to 10,000.

6. The composition according to any one of claims 1 to 5, wherein the composition is a crystal precipitation inhibitor.

7. The composition according to any one of claims 1 to 6, which is a cosmetic or an external skin preparation.

8. A method for inhibiting crystal precipitation, comprising blending a composition containing components (A) niacinamide and (B) tranexamic acid with (C) pyrrolidonecarboxylic acid or a salt thereof, (D) one or more phosphates selected from the group consisting of sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate, and (E) one or more sugar alcohols selected from the group consisting of erythritol, sorbitol, and maltitol.

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