Temperature Control Device

Abstract

The present invention provides a temperature control device that accurately indicates the temperature of a temperature adjustment block and achieves precise temperature control by causing a temperature measurement unit and a wire to reach a temperature equal to that of the temperature adjustment block. A temperature control device 1, which comprises a temperature adjustment block 2 that can accommodate a sample and / or a reagent and a temperature control unit 3 that controls the temperature of the temperature adjustment block 2, has a first opening 8 formed in the temperature adjustment block 2 and a pressing part 7 for inserting a temperature sensor 4 having a temperature measuring part 4a and a wire 4b so that the temperature measuring part 4a abuts against the temperature adjustment block 2 inside the first opening 8, wherein the temperature measuring part 4a and the wire 4b are pressed against the inner wall surface of the first opening 8 by the pressing part 7.

Description

[Technical Field]

[0001] The present invention relates to a temperature control device used in a genetic testing device, an automatic analyzer, or the like. [Background technology]

[0002] Genetic testing devices amplify and detect DNA (deoxyribonucleic acid) contained in samples. Polymerase Chain Reaction (PCR) is a widely used method for amplifying DNA. In PCR, a sample solution containing DNA is mixed with a solution containing a DNA amplification reagent. The DNA is denatured into a single strand at, for example, 94°C, and then a complementary strand is synthesized at 60°C. Repeating these temperature changes exponentially amplifies DNA. However, this temperature cycle requires time for temperature changes, such as cooling from 94°C to 60°C and heating from 60°C to 94°C. Therefore, there is a need to speed up the temperature change process in order to shorten testing times.

[0003] To speed up temperature control, it is possible to increase the amount of heat absorbed by the temperature control device, or to reduce the size of the temperature control block to control the temperature and reduce its heat capacity, thereby speeding up temperature changes. Either method requires high-precision temperature control, but when the temperature control block is downsized, the temperature sensor must also be downsized. Furthermore, when the temperature control block and temperature sensor are downsized, it becomes difficult to closely attach and fix the temperature sensor to the temperature control block. If a gap occurs between the temperature sensor and the temperature control block and contact thermal resistance increases, the temperature indicated by the temperature sensor will be lower than the actual temperature of the temperature control block, making high-precision temperature control difficult.

[0004] To address these issues, structures for fixing a temperature sensor to a controlled object have been considered. For example, Patent Document 1 discloses a thermistor mounting structure in which the tip of a pressing part abuts against the side of a thermistor inserted inside a temperature sensing tube, and the angle formed between the side of the thermistor at the tube insertion end and the pressing part is an acute angle.

[0005] Furthermore, Patent Document 2 describes a structure with dedicated fixing parts, which includes a sensor holding part that contacts almost the entire detection part of the temperature sensor, and an attachment part that is formed integrally with the sensor holding part and can be attached and detached to the pipe, with the attachment part having a double structure with a gap. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Laid-Open No. 2015-152298 [Patent Document 2] Japanese Patent Application Laid-Open No. 2003-75031 Summary of the Invention [Problem to be solved by the invention]

[0007] In Patent Document 1, the temperature measuring portion of the thermistor is inserted into an opening, and a thermistor mounting structure for fixing the temperature measuring portion is further inserted into the opening. However, since only the thermistor's temperature measuring part is pressed against the inner wall, and the wiring connected to the temperature measuring part does not come into contact with the object being measured, the temperature of the wiring becomes equal to the ambient air temperature, not the temperature of the object being measured. This causes the temperature of the temperature measuring part to change due to the temperature difference between the temperature measuring part and the wiring, resulting in a problem where the temperature of the temperature measuring part differs from the actual temperature of the object being measured.

[0008] In addition, Patent Document 2 provides a structure in which a sensor holder that contacts the temperature sensor's detection unit is provided, and the sensor holder is fixed to the temperature measuring unit that is the measurement target. This allows the temperature sensor to be detachably fixed to the temperature measuring unit. However, since the temperature measured is a surface temperature, there is a problem that a difference occurs between the surface temperature and the internal temperature of the controlled object. For example, when trying to measure a controlled object temperature that is higher than room temperature, the sensor reading will be lower than the internal temperature of the controlled object. Also, as in Patent Document 1, there is a problem in that the temperature sensor wiring is not fixed to the measured object, and a temperature difference occurs between the temperature measuring unit and the wiring, which prevents the temperature measuring unit from correctly outputting the temperature of the measured object.

[0009] SUMMARY OF THE INVENTION Therefore, the present invention provides a temperature control device that can accurately indicate the temperature of the temperature control block by making the temperature measuring unit and wiring the same temperature as the temperature control block, thereby realizing highly accurate temperature control. [Means for solving the problem]

[0010] In order to solve the above problems, the temperature control device of the present invention is a temperature control device comprising a temperature control block capable of containing samples and / or reagents and a temperature control unit that controls the temperature of the temperature control block, and is characterized in that it has a first opening formed in the temperature control block and a pressing unit that inserts a temperature sensor having a temperature measuring unit and wiring so that the temperature measuring unit abuts against the temperature control block within the first opening, and the pressing unit presses the temperature measuring unit and wiring against the inner wall surface of the first opening. [Effects of the Invention]

[0011] According to the present invention, it is possible to provide a temperature control device that can accurately indicate the temperature of the temperature control block by making the temperature measuring unit and wiring the same temperature as the temperature control block, thereby achieving highly accurate temperature control. Problems, configurations, and effects other than those described above will become apparent from the following description of the embodiments. [Brief explanation of the drawings]

[0012] [Figure 1]1 is a schematic perspective view of a temperature control device according to a first embodiment of the present invention. [Figure 2] 2 is a schematic cross-sectional view taken along line AA' of a temperature adjustment block constituting the temperature control device shown in FIG. [Figure 3] 2 is a schematic cross-sectional view taken along the line BB' of a temperature adjustment block constituting the temperature control device shown in FIG. [Figure 4] 2 is a schematic cross-sectional view of the temperature control block taken along line BB' in FIG. 1, showing a case where one surface of a pressing part constituting the temperature control device is flat. FIG. [Figure 5] 2 is a schematic cross-sectional view along the line BB' of the temperature control block shown in FIG. 1, showing a case where the cross section of a pressing part constituting the temperature control device is polygonal. FIG. [Figure 6] FIG. 6 is a schematic cross-sectional view of a temperature adjustment block constituting a temperature control device according to a second embodiment of the present invention. [Figure 7] FIG. 10 is a schematic cross-sectional view of a temperature adjustment block constituting a temperature control device according to a third embodiment of the present invention. [Figure 8] FIG. 10 is a schematic cross-sectional view of a temperature adjustment block constituting a temperature control device according to a fourth embodiment of the present invention. [Figure 9] FIG. 10 is a schematic cross-sectional view of a temperature adjustment block constituting a temperature control device according to a fifth embodiment of the present invention. [Figure 10] 1. FIG. 4 is a schematic cross-sectional view of a temperature adjustment block constituting a temperature control device according to a sixth embodiment of the present invention, and corresponds to the cross section BB' of FIG. [Figure 11] 1. FIG. 4 is a schematic cross-sectional view of a temperature adjustment block constituting a temperature control device according to a sixth embodiment of the present invention, and corresponds to the cross section AA' in FIG. DETAILED DESCRIPTION OF THE INVENTION

[0013] Hereinafter, an embodiment of the present invention will be described with reference to the drawings. [Example]

[0014] FIG. 1 is a schematic perspective view of a temperature control device according to a first embodiment of the present invention. As shown in FIG. The temperature control device 1 is composed of a temperature control block 2, a temperature control section 3, a temperature sensor 4, a heat dissipation section 6, a first opening 8 formed in the temperature control block 2 for inserting the temperature sensor 4, and a pressing section 7 (described later) for inserting the temperature sensor 4 into the first opening 8 (described later). The temperature control block 2 is composed of, for example, a cylindrical section (hollow section) and a flat section, and can accommodate a sample and / or a reagent. The shape of the temperature control block 2 is not limited to this, and may be any shape that can accommodate a sample and / or a reagent and allow temperature control by the temperature control section 3. The temperature sensor 4 is composed of a temperature measuring section 4a and a wiring 4b. One end of the wiring 4b is connected to the temperature measuring section 4a, and the other end is connected to a data logger or data collection device (not shown).

[0015] FIG. 2 is a schematic cross-sectional view taken along line A-A' of a temperature control block constituting the temperature control device 1 shown in FIG. 1. FIG. 3 is a schematic cross-sectional view taken along line B-B' of a temperature control block constituting the temperature control device shown in FIG. 1. FIG. 4 is a schematic cross-sectional view taken along line B-B' of the temperature control block shown in FIG. 1, showing a case in which one surface of a pressing unit constituting the temperature control device 1 is flat. FIG. 5 is a schematic cross-sectional view taken along line B-B' of the temperature control block shown in FIG. 1, showing a case in which a cross section of a pressing unit 7 constituting the temperature control device is polygonal. As shown in FIGS. 2 to 5, a first opening 8 is provided in the temperature control block 2, and a temperature sensor 4 is inserted into the first opening 8. At this time, the pressing unit 7 presses the temperature measuring unit 4a constituting the temperature sensor 4 against the inner wall surface of the first opening 8, and the tip of the temperature measuring unit 4a abuts against the temperature control block 2. Furthermore, the side surface of the pressing unit 7 shown in FIG. 2 presses the wiring 4b constituting the temperature sensor 4 against the inner wall surface of the first opening 8. Here, the temperature control block 2 is made of a material with high thermal conductivity, such as aluminum or copper.

[0016] In this embodiment, the temperature sensor 4 includes a temperature measuring unit 4a that is pressed against the inner wall surface of the first opening 8 and contacts the temperature control block 2. This reduces the thermal contact resistance between the temperature control block 2 and the temperature measuring unit 4a, enabling accurate detection of the temperature of the temperature control block 2. Furthermore, the wire 4b that constitutes the temperature sensor 4 is pressed against the inner wall surface of the first opening 8 by the pressing unit 7 and contacts the temperature control block 2. This causes the wire 4b to have the same temperature as the temperature control block 2, and the temperatures of the temperature measuring unit 4a and the wire 4b are both equal to the temperature of the temperature control block 2. This makes it possible to ignore the influence of the ambient temperature on the temperature of the wire 4b, and to ignore the influence of heat radiation from the temperature measuring unit 4a to the ambient air via the wire 4b. This is because, as long as the length of the wire 4b within the first opening 8 is within a range of three to five times the longitudinal length of the temperature measuring unit 4a, the influence of heat radiation from the temperature measuring unit 4a to the ambient air via the wire 4b can be ignored.

[0017] Furthermore, since the wiring 4b is fixed to the temperature control block 2 by the pressing portion 7, even if force is applied to the wiring 4b when the temperature control device 1 is moved, the positional relationship between the temperature measuring portion 4a and the temperature control block 2 does not change, allowing for highly reproducible and reliable temperature measurements and highly reliable temperature control.

[0018] The first opening 8 may be filled with thermally conductive grease or adhesive to reduce the contact thermal resistance at the interface between the temperature measuring unit 4a of the temperature sensor 4 and the inner wall surface of the first opening 8. Furthermore, the length of the wire 4b of the temperature sensor 4 that contacts and is fixed to the inner wall surface of the first opening 8 is preferably approximately the same as or longer than the length of the temperature measuring unit 4a. That is, the first opening 8 is preferably opened from the end face of the temperature control block 2 to a depth at least twice the length of the temperature measuring unit 4a. Furthermore, the pressing unit 7 is preferably made of a flexible material. By constructing the pressing unit 7 from a resin component such as polypropylene, polyethylene, or polyester, the pressing unit 7 is compressed and pressed into the opening 8, pressing the temperature measuring unit 4a and the wire 4b against the inner wall surface of the first opening 8, thereby reducing the contact thermal resistance. Furthermore, by configuring the diameter of the first opening 8 to be smaller than the sum of the diameters of the pressing unit 7 and the wire 4b, the pressing unit 7 can press the wire 4b into the first opening 8. However, the pressing portion 7 is not limited to a cylinder, and may have a shape such as pressing portion 7a, which has a cylindrical cross section with a partially flat surface, as shown in FIG. 4, or pressing portion 7b, which has a polygonal cross section, as shown in FIG. 5. In the case of pressing portion 7a, which has a partially flat surface, as shown in FIG. 4, the wiring 4b constituting the temperature sensor 4 is pressed against the inner wall surface of the first opening 8 by the flat surface of pressing portion 7a. In the case of polygonal pressing portion 7b, as shown in FIG. 5, the wiring 4b constituting the temperature sensor 4 is pressed against the inner wall surface of the first opening 8 by one side (flat surface) of pressing portion 7b. The temperature control portion 3 may be formed by, for example, a heater, a Peltier element, a heat pump, or the like.

[0019] As described above, according to this embodiment, by making the temperature measuring unit and wiring equal in temperature to the temperature control block, it is possible to provide a temperature control device that can accurately indicate the temperature of the temperature control block and achieve highly accurate temperature control. The pressing unit presses the temperature measuring unit that constitutes the temperature sensor against the inner wall surface of the first opening provided in the temperature control block, and presses the wiring that constitutes the temperature sensor against the inner wall surface of the first opening. As a result, not only the temperature measuring unit of the temperature sensor but also the wiring comes into close contact with the temperature control block, so that the temperature of the temperature measuring unit and the wiring become equal to that of the temperature control block, and the temperature of the temperature control block can be measured accurately. [Example]

[0020] 6 is a schematic cross-sectional view of a temperature control block 2 constituting a temperature control device 1a according to a second embodiment of the present invention. This embodiment differs from the first embodiment in that it has a second opening 9 that communicates with a first opening 8 provided in the temperature control block 2. The same components as those in the first embodiment are given the same reference numerals, and redundant explanations will be omitted below.

[0021] As shown in Fig. 6, a second opening 9 is provided in a first opening 8 provided in the temperature control block 2 in a direction toward the center of the temperature control block 2 (+Z direction). In this case, the second opening 9 is connected to the first opening 8 and is structured to penetrate toward the bottom surface of the temperature control block 2 (-Y direction). Here, the second opening 9 is desirably provided at a position that includes at least the area of ​​the first opening 8 where the temperature measuring unit 4a constituting the temperature sensor 4 abuts against the temperature control block 2. However, this is not limiting, and the second opening 9 may be provided at a position that includes the area of ​​the first opening 8 where the temperature measuring unit 4a is present.

[0022] In this embodiment, the second opening 9 allows visual confirmation that the temperature measuring unit 4a of the temperature sensor 4 is in close contact with the first opening 8, suppressing variations during assembly and enabling the temperature sensor 4 to accurately measure the temperature of the temperature control block 2. Furthermore, by providing the second opening 9, when the first opening 8 is filled with thermally conductive grease or adhesive and the temperature sensor 4 is inserted, the thermally conductive grease pressed by the temperature sensor 4 and the pressing unit 7 is extruded from the second opening 9, which communicates with the first opening 8. This allows the first opening 8 and the temperature sensor 4 to be filled with thermally conductive grease, reducing contact thermal resistance and enabling accurate temperature measurement of the temperature control block 2. Furthermore, by checking the thermally conductive grease through the second opening 9, it is possible to confirm that the temperature measuring unit 4a is inserted into the first opening 8 and pressed against the inner wall surface. Here, if the opening area of ​​the second opening 9 is large, the heat transfer area from the temperature control unit 3 to the temperature control block 2 is small, resulting in a smaller temperature change. Therefore, it is desirable that the opening area of ​​the second opening 9 be equal to or smaller than that of the first opening 8.

[0023] As described above, according to this embodiment, in addition to the effects of the above-mentioned embodiment 1, by having the second opening 9, it is possible to visually confirm that the temperature measuring part 4a is in close contact with the first opening 8, thereby suppressing variations during assembly and enabling the temperature sensor 4 to accurately measure the temperature of the temperature control block 2. Furthermore, by providing the second opening 9, when filling the first opening 8 with thermally conductive grease or adhesive and inserting the temperature sensor 4, the thermally conductive grease pushed in by the temperature sensor 4 and pressing portion 7 is pushed out from the second opening 9, which communicates with the first opening 8. This makes it possible to fill the first opening 8 and the temperature sensor 4 with thermally conductive grease, reducing contact thermal resistance and enabling the temperature of the temperature control block 2 to be measured with high accuracy. [Example]

[0024] FIG. 7 is a schematic cross-sectional view of the temperature control block 2 that constitutes the temperature control device 1b according to Embodiment 3 of the present invention. In this embodiment, it is different from Embodiment 1 in that the cross-section of the first opening 8 provided in the temperature control block 2 has a shape that narrows from the outer peripheral side (-Z direction) to the central portion (+Z direction) of the temperature control block 2. The same reference numerals are given to the same components as in Embodiment 1, and duplicate descriptions are omitted below.

[0025] As shown in FIG. 7, in the direction (+Z direction) toward the center of the temperature control block 2 in the first opening 8, when the diameter of the temperature measurement part 4a contacting the temperature control block 2 is r1 and the diameter of the outer peripheral side of the temperature control block 2 (in FIG. 7, -Z direction) is r2, it has a structure where r1 < r2. At the same time, the pressing part 7 also has a shape such that the diameter in the direction (+Z direction) toward the center of the temperature control block 2 is substantially the same as r1, and the diameter of the outer peripheral side of the temperature control block 2 (in FIG. 7, -Z direction) is substantially the same as r2.

[0026] In this embodiment, the pressing part 7 has a structure that narrows more in the direction (+Z direction) toward the center of the temperature control block 2. By inserting the pressing part 7 in the +Z direction, the side surface of the pressing part 7 and the inner wall surface of the first opening 8 are pressed, and the wiring 4b constituting the temperature sensor 4 is in close contact with the first opening 8. Since the contact thermal resistance is reduced, the temperature of the temperature control block 2 can be detected more accurately by the temperature measurement part 4 constituting the temperature sensor 4. Here, the shapes of the first opening 8 and the pressing part 7 are not limited to a conical shape, and may be a polygonal shape, a shape combining two or more diameters, or a shape narrowed stepwise as long as it narrows in the +Z direction.

[0027] As described above, according to this embodiment, in addition to the effects of the above-described Embodiment 1, it becomes easier to further reduce the contact thermal resistance by improving the adhesion between the wiring 4b constituting the temperature sensor 4 and the first opening 8.

Embodiment

[0028] 8 is a schematic cross-sectional view of a temperature control block 2 constituting a temperature control device 1c according to a fourth embodiment of the present invention. This embodiment differs from the first embodiment in that the pressing portion 7 has two diameter stages. The same components as those in the first embodiment are given the same reference numerals, and redundant explanations will be omitted below.

[0029] 8, the pressing portion 7 has a shape with two diameter stages, r3 and r4. The diameter of the pressing portion 7 in the area where the temperature measuring portion 4a constituting the temperature sensor 4 is pressed against the inner wall surface of the first opening 8 is r3, and the diameter of the area where the wiring 4b constituting the temperature sensor 4 is pressed is r4. In this embodiment, the portion of pressing portion 7 with diameter r3 presses temperature measuring portion 4a, which constitutes temperature sensor 4, not only in the +Z direction (toward the center of temperature control block 2) but also in the -Y direction against first opening 8. In addition, the portion of pressing portion 7 with diameter r4 presses wiring 4b, which constitutes temperature sensor 4, against the inner wall surface of first opening 8. These structures increase the contact area between temperature measuring portion 4a and the inner wall surface of first opening 8, reducing the contact thermal resistance between temperature measuring portion 4a and temperature control block 2, allowing temperature sensor 4 to accurately measure the temperature of temperature control block 2. Here, the diameter of the pressing part 7 is not limited to two stages, r3 and r4, but may be formed in three or more stages. Furthermore, the pressing direction of the temperature measuring part 4a pressed by the pressing part 7 is not limited to the -Y direction, but may be the +Y direction or the X direction.

[0030] As described above, according to this embodiment, in addition to the effects of the above-mentioned embodiment 1, the contact area between the temperature measuring part 4a and the inner wall surface of the first opening 8 is increased, the contact thermal resistance between the temperature measuring part 4a and the temperature control block 2 is reduced, and the temperature of the temperature control block 2 can be accurately measured by the temperature sensor 4. [Example]

[0031] 9 is a schematic cross-sectional view of a temperature control block 2 constituting a temperature control device 1d according to a fifth embodiment of the present invention. This embodiment differs from the first embodiment in that it has a second opening 9 communicating with a first opening 8 provided in the temperature control block 2, and pressing is performed from the second opening 9 using a second pressing unit 10. The same components as those in the first embodiment are given the same reference numerals, and redundant explanations will be omitted below.

[0032] As shown in Figure 9, this embodiment has a second opening 9 that communicates with the first opening 8 provided in the temperature control block 2, and by inserting a second pressing part 10 through the second opening 9, the temperature measuring part 4a that constitutes the temperature sensor 4 is pressed against the inner wall surface of the first opening 8.

[0033] In this embodiment, the pressing unit 7 presses the temperature measuring unit 4a constituting the temperature sensor 4 against the first opening 8 in the +Z direction (toward the center of the temperature control block 2), and the second pressing unit 10 further presses the temperature measuring unit 4a in the +Y direction (vertically upward) against the inner wall surface of the first opening 8. This increases the contact area of ​​the temperature measuring unit 4a with the inner wall surface of the first opening 8, reducing the contact thermal resistance and allowing the temperature measuring unit 4a to accurately measure the temperature of the temperature control block 2. Here, the shapes of the second opening 9 and the second pressing unit 10 are not limited to cylindrical and may be polygonal.

[0034] As described above, according to this embodiment, in addition to the effects of the first embodiment, it is possible to achieve the same effects as those of the fourth embodiment. [Example]

[0035] 10 is a schematic cross-sectional view of a temperature control block 2 constituting a temperature control device 1e according to a sixth embodiment of the present invention, and corresponds to the cross section B-B' in FIG. 1. FIG. 11 is a schematic cross-sectional view of a temperature control block constituting a temperature control device 1e according to a sixth embodiment of the present invention, and corresponds to the cross section A-A' in FIG. This embodiment differs from the first embodiment in that a through-hole 11 is formed in the pressing portion 7, and the wiring 4b constituting the temperature sensor 4 is connected to the through-hole 11. The same components as those in the first embodiment are denoted by the same reference numerals, and redundant explanations will be omitted below.

[0036] 10 and 11, a through hole 11 is formed in the pressing portion 7, and the wiring 4b constituting the temperature sensor 4 is passed through the through hole 11 to the outside of the temperature control block 2. It is desirable that the cross-sectional shape of the through hole 11 is substantially the same as the cross-sectional shape of the wiring 4b constituting the temperature sensor 4. In this embodiment, the wiring 4b constituting the temperature sensor 4 can contact the temperature control block 2 via the pressing portion 7, and the contact area can be increased, so that the temperature of the temperature control block 2 can be measured with high accuracy by the temperature measuring portion 4a. Here, it is desirable that the pressing portion 7 be made of a material with high thermal conductivity.

[0037] As described above, according to this embodiment, it is possible to achieve the same effects as in the first embodiment.

[0038] The present invention is not limited to the above-described embodiments, but includes various modifications. For example, the above-described embodiments have been described in detail to clearly explain the present invention, and the present invention is not necessarily limited to those including all of the described configurations. Furthermore, it is possible to replace part of the configuration of one embodiment with the configuration of another embodiment, and it is also possible to add the configuration of another embodiment to the configuration of one embodiment. [Explanation of symbols]

[0039] 1, 1a, 1b, 1c, 1d, 1e...Temperature control device, 2...Temperature control block, 3...Temperature control section, 4...Temperature sensor, 4a...Temperature measuring section, 4b...Wiring, 6...Heat dissipation section, 7...Pressing section, 7a...Pressing section with a part of a cylinder being flat, 7b...Polygonal pressing section, 8...First opening, 9...Second opening, 10...Second pressing section, 11...Through hole

Claims

1. A temperature control device including a temperature control block capable of accommodating a sample and / or a reagent and a temperature control unit that controls the temperature of the temperature control block, a first opening formed in the temperature control block; a pressing portion that inserts a temperature sensor having a temperature measuring portion and wiring into the first opening so that the temperature measuring portion abuts against the temperature control block, The temperature control device is characterized in that the pressing portion presses the temperature measuring portion and the wiring against the inner wall surface of the first opening portion.

2. 2. The temperature control device according to claim 1, The temperature control device, wherein the pressing portion has at least one of a cylindrical shape, a cylindrical shape having a flat surface on a part of its cross section, and a polygonal cross section.

3. 2. The temperature control device according to claim 1, the first opening is formed in a direction toward the center of the temperature control block, a second opening is provided in the temperature control block; The temperature control device is characterized in that the second opening communicates with the first opening and penetrates the temperature control block toward a bottom surface thereof.

4. 4. The temperature control device according to claim 3, A temperature control device characterized in that the second opening is provided at a position including the area of ​​the first opening where the temperature measuring unit abuts the temperature control block or at a position including the area of ​​the first opening where the temperature measuring unit is present.

5. 5. The temperature control device according to claim 4, A temperature control device, characterized in that the opening area of ​​the second opening is equal to or smaller than the opening area of ​​the first opening.

6. 2. The temperature control device according to claim 1, The temperature control device is characterized in that the first opening has a shape that narrows toward the center of the temperature control block.

7. 7. The temperature control device according to claim 6, The temperature control device is characterized in that the pressing portion has a shape in which the diameter of the cross section decreases toward the center of the temperature control block.

8. 2. The temperature control device according to claim 1, The temperature control device is characterized in that the pressing portion has a shape having a plurality of diameter regions in a direction toward the center of the temperature control block.

9. 9. The temperature control device according to claim 8, A temperature control device characterized in that the pressing portion has a shape in which the diameter of the area that presses the temperature measuring portion against the inner wall surface of the first opening is smaller than the diameter of the area that presses the wiring against the inner wall surface of the first opening.

10. 4. The temperature control device according to claim 3, A temperature control device comprising: a second pressing portion that presses the temperature measuring portion vertically upward from the second opening onto the inner wall surface of the first opening.

11. 2. The temperature control device according to claim 1, The temperature control device is characterized in that the pressing portion has a through hole, and the cross-sectional shape of the through hole is substantially the same as the cross-sectional shape of the wiring.

12. The temperature control device according to any one of claims 2, 5, 7, 9, and 11, The temperature control device is characterized in that the temperature control block is composed of a cylindrical portion capable of accommodating a sample and / or a reagent and a flat portion in which the first opening is formed.

Images